MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| UAU | UAU (UpApU) is a trinucleotide that is identified as the RNA codon for tyrosine, which is involved in protein synthesis. UAU can be used in research about the interaction between RNA codons, tRNAs, and ribosomes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UpApU. CAS No. 752-71-6. Pack Sizes: 1 mg. Product ID: HY-159807. |  |
| Ubamatamab | Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN4018. CAS No. 2305629-50-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99539. | |
| UBE2T/FANCL-IN-1 | UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1359415-02-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126539. | |
| Ubiquinone-1 | Ubiquinone-1 is an intermediate in the synthesis of Coenzyme Q. Ubiquinone-1 can be reduced by NADPH oxidase, hepatoma cells, Ascorbic acid (HY-B0166)[1][2][3][4][5]. Uses: Scientific research. Group: Natural products. CAS No. 727-81-1. Pack Sizes: 1 mg (40 mM * 100 ?L in Ethanol); 5 mg (40 mM * 500 ?L in Ethanol); 10 mg (40 mM * 1 mL in Ethanol); 25 mg (40 mM * 2.5 mL in Ethanol); 50 mg (40 mM * 5 mL in Ethanol); 100 mg (40 mM * 10 mL in Ethanol). Product ID: HY-113449. | |
| Ublituximab | Ublituximab (LFB-R603; TG-1101; TGTX-1101) is a next-generation, type 1 chimeric monoclonal antibody targeting a unique epitope on the CD20 antigen. Ublituximab has anticancer effects [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LFB-R603; TG-1101; TGTX-1101. CAS No. 1174014-05-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99538. | |
| Ubrogepant | Ubrogepant (MK-1602) is an orally active and selective antagonist of calcitonin gene-related peptide receptor ( CGRP ). Ubrogepant has high affinity for CGRP receptors in human and rhesus monkeys, and can effectively block the cAMP response stimulated by α-CGRP. Ubrogepant can be used in the study of acute migraine [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-1602. CAS No. 1374248-77-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12366. | |
| UBX1325 | UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2271269-01-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150069. | |
| UC2288 | UC2288 is a potent and orally active p21 attenuator (relatively selective activity for p21), which is synthesized based Sorafenib (HY-10201). UC2288 potently inhibits cancer cell growth by inducing apoptosis. UC2288 has no inhibition of VEGFR2 and Raf kinases even at 10 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394011-91-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-112780. | |
| UCB-6876 | UCB-6876 is a TNF? inhibitor. UCB-6876 can specifically bind to the asymmetric crystalline form of the TNF-? trimer, with a KD of 22 ?M[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 637324-45-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156454. | |
| UCB-9260 | UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer. UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar Kd of 13?nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1515888-53-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133122. | |
| Ucenprubart | Ucenprubart is an anti- CD200R1 human IgG4κ monoclonal antibody [1]. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003). Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2414559-57-0. Pack Sizes: 1 mg. Product ID: HY-P990770. | |
| Ucf-101 | Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2 , with an IC 50 of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC 50 >200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 313649-08-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125959. | |
| UCL-TRO-1938 | UCL-TRO-1938 is a potent small molecule allosteric activator of PI3K? with an EC50 value of approximately 60 ?M. UCL-TRO-1938 can induce cell proliferation and has cardioprotective effects from ischaemia reperfusion injury and enhances nerve regeneration following nerve crush[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2919575-27-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154848. | |
| UCPH-101 | UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1118460-77-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10914. | |
| Udenafil | Udenafil (DA8159) is a potent, selective and orally active phosphodiesterase type 5 (PDE5) inhibitor. Udenafil also inhibits cGMP hydrolysis and can be used for erectile dysfunction research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DA8159. CAS No. 268203-93-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18253. | |
| Udonitrectag | Udonitrectag (REC 0559), a low molecular weight compound that mimics NGF, aims to address the issue of NGF stability [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: REC 0559. CAS No. 1458063-04-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109194. | |
| UDP-Galactose disodium | UDP-Galactose disodium is a natural agonist of the P2Y 14 receptor with an EC 50 of 0.67 μM for the hP2Y 14 receptor. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V ( B4GALT5 ). In addition, UDP-Galactose disodium is required for the biosynthesis of several abundant glycoconjugates that form the surface glycocalyx of Leishmania major [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 137868-52-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114364. | |
| UDP-GalNAc disodium | UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor [1]. Uses: Scientific research. Group: Natural products. Alternative Names: UDP-N-acetyl-D-galactosamine disodium. CAS No. 108320-87-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-114365. | |
| UDP-GalNAz disodium | UDP-GalNAz (UDP-N-azidoacetylgalactosamine) disodium is the analogue of UDP-GalNAc (HY-114365). UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor[1][2][3][4]. UDP-GalNAz (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UDP-N-azidoacetylgalactosamine disodium. CAS No. 653600-61-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-145934. | |
| UDP-GlcNAc disodium | UDP-GlcNAc Disodium Salt (UDP-?-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT). Uses: Scientific research. Group: Signaling pathways. Alternative Names: UDP-?-D-N-Acetylglucosamine disodium. CAS No. 91183-98-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112174. | |
| UDP-GlcNAz disodium | UDP-GlcNAz disodium is a substrate for UDP-GlcNAc:polypeptidyltransferase [1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1611490-64-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145934A. | |
| UDP-glucuronic acid trisodium | UDP-?glucuronic acid trisodium (Uridine-5'-diphosphoglucuronic acid trisodium salt) is a critical precursor for essential glycoconjugates across biological kingdoms, ranging from mammalian glycosaminoglycans and plant cell wall polysaccharides to bacterial capsule glycoglycerolipids. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Uridine 5'-diphosphoglucuronic acid trisodium salt. CAS No. 63700-19-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7033. | |
| UDP-rhamnose | UDP-rhamnose is one of the substrates for pectin synthesis in cell wall. UDP-rhamnose can be identified in fungi. UDP-rhamnose is one of the most common sugar donors in plants. UDP-rhamnose synthesis requires recombinant enzymes. UDP-rhamnose can be synthesized from UDP-glucose through the consecutive three-step reaction catalyzed by a single structure enzyme in plants[1][2]. Uses: Scientific research. Group: Natural products. CAS No. 1955-26-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10573. | |
| UDP-xylose disodium | UDP-xylose disodium is an endogenous sugar nucleotide and a catalytic substrate of UDP-xylose disodium synthase (UXS). UDP-xylose disodium is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites and oligosaccharides in plants, vertebrates and fungi, and participates in the synthesis of proteoglycans as a glycosyl donor. UDP-xylose disodium participates in the regulation of the synthesis of extracellular matrix components and can be used to study the mechanism of proteoglycan biosynthesis in glycobiology and related diseases (such as connective tissue diseases)[1][2]. Uses: Scientific research. Group: Natural products. CAS No. 108320-89-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N11287A. | |
| UGT1A1-IN-1 | UGT1A1-IN-1 (compound 2) is a non-competitive inhibitor of UGT1A1 , which can inhibit the 1-O-glucuronidation process mediated by UGT1A1 with a K i value of 5.02 μM. UGT1A1-IN-1 (compound 2) can bind on UGT1A1 at the same ligand-binding site as bilirubin (HY-N0323). UGT1A1-IN-1 can serve as a turn-on fluorescent probe substrate for UGT1A1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2097024-37-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160250. | |
| UK122 | UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC 50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC 50 >100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 940290-58-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111056. | |
| UK 356618 | UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC50 of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with MMP-3[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 230961-08-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-107394. | |
| UK-383367 | UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 348622-88-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13102. | |
| UK-5099 | UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier ( MPC ). UK-5099 (PF-1005023) inhibits pyruvate-dependent O 2 consumption with an IC 50 of 50 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-1005023. CAS No. 56396-35-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15475. | |
| UK-78282 hydrochloride | UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC 50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 136647-02-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W013727. | |
| Ulefnersen | Ulefnersen (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen can be used in the research of Amyotrophic Lateral Sclerosis (ALS) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ION-363. CAS No. 2589926-25-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147410. | |
| Ulifloxacin | Ulifloxacin is a broad-spectrum quinolone antibiotic. Ulifloxacin is the active metabolite of Prulifloxacin (HY-B0024). Ulifloxacin has anti-bacterial activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 112984-60-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108279. | |
| Uliledlimab | Uliledlimab is a potent against CD73 humanizedized monoclonal antibody. Uliledlimab inhibits the conversion of extracellular adenosine monophosphate (AMP) to adenosine. Uliledlimab can be used in research of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TJ004309. CAS No. 2378407-27-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99169. | |
| Ulimorelin | Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC 50 of 29 nM and a K i of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TZP-101. CAS No. 842131-33-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-14903. | |
| Ulinastatin | Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Uristatin. CAS No. 80449-31-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134616. | |
| Ulipristal | Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CDB-3236; Deacetyl CDB-2914. CAS No. 159811-51-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14959. | |
| Ulipristal acetate | Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM). Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CDB-2914. CAS No. 126784-99-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16508. | |
| Ulixacaltamide | Ulixacaltamide (Z944) is an orally available T-type calcium channel antagonist that can slow the progression of epilepsy. Ulixacaltamide effectively reduces tremor in a normal alkaline tremor animal model. Ulixacaltamide reverses thermal hyperalgesia and mediates pain relief [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Z944; PRAX-944. CAS No. 1199236-64-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120546. | |
| Ulixertinib | Ulixertinib (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC 50 of <0.3 nM against ERK2. Ulixertinib (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BVD-523; VRT752271. CAS No. 869886-67-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15816. | |
| Ulixertinib hydrochloride | Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC 50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BVD-523 hydrochloride; VRT752271 hydrochloride. CAS No. 1956366-10-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15816A. | |
| ULK-101 | ULK-101 is a potent and selective ULK1 inhibitor, with IC 50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2443816-45-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114490. | |
| Ulocuplumab | Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti- CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody. CAS No. 1375830-34-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99272. | |
| Ulviprubart | Ulviprubart (ABC-008) is a monoclonal antibody targeting the KLRG1 receptor that selectively depletes highly differentiated cytotoxic T cells. Ulviprubart can be used in the study of inclusion body myositis (IBM)[1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ABC-008. CAS No. 2569434-60-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990026. | |
| Umbelliferone | Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Hydroxycoumarin; Hydrangin; NSC 19790. CAS No. 93-35-6. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N0573. | |
| Umbelliprenin | Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase) [1]. Uses: Scientific research. Group: Natural products. CAS No. 23838-17-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-127029A. | |
| Umbralisib | Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε ( CK1ε ) inhibitor, with EC 50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TGR-1202; RP5264. CAS No. 1532533-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279. | |
| Umbralisib hydrochloride | Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε ( CK1ε ) inhibitor, with EC 50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TGR-1202 hydrochloride; RP5264 hydrochloride. CAS No. 1532533-78-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279C. | |
| Umeclidinium bromide | Umeclidinium bromide is a novel mAChR antagonist. The affinity ( K i ) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK573719A. CAS No. 869113-09-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12100. | |
| UMI-77 | UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 ?M). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members. Uses: Scientific research. Group: Signaling pathways. CAS No. 518303-20-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18628. | |
| Umifenovir | Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells [1] [2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro [2]. Umifenovir shows anti-inflammatory activity [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 131707-25-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14904. | |
| Umifenovir hydrochloride | Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells [1] [2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 131707-23-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14904A. | |
| Umirolimus | Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 851536-75-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122402. | |
| UMK57 | UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 342595-74-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122236. | |
| UNBS5162 | UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 956590-23-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16509. | |
| UNC0224 | UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1197196-48-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-10929. | |
| UNC0321 | UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications[1][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1238673-32-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10930. | |
| UNC0379 | UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 ( KMT5A ) with an IC 50 of 7.3 μM, K D value of 18.3 μM. UNC0379 can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620401-82-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12335. | |
| UNC 0631 | UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC50 of 4 nM. UNC 0631 potently reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 25 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1320288-19-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13808. | |
| UNC0638 | UNC0638 selectively inhibits G9a and GLP histone methyltransferases with IC 50 of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin ( HbF ) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti- FMDV (foot-and-mouth disease virus) and anti- VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255580-76-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15273. | |
| UNC0642 | UNC0642 is a potent and selective lysine methyltransferases G9a and GLP inhibitor, with an IC50 of <2.5 nM for G9a. Uses: Scientific research. Group: Signaling pathways. CAS No. 1481677-78-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13980. | |
| UNC10217938A | UNC10217938A is a 3-deazapteridine analog with strong oligonucleotide enhancing effects. UNC10217938A enhances oligonucleotides effects by modulating their intracellular trafficking and release from endosomes. UNC10217938A also enhances the effects of antisense and siRNA oligonucleotides[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1347749-97-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136151. | |
| UNC1215 | UNC1215 is a potent and selective inhibitor for the methyllysine (Kme) reading domain function of L3MBTL3 with a Kd value of 120 nM and an IC50 of 40 nM. UNC1215 has the potential to treat malignant brain tumor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415800-43-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15649. | |
| UNC1999 | UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH2/1 with IC50s of <10 nM and 45 nM, repectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431612-23-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15646. | |
| UNC2025 | UNC2025 is a potent, ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1429881-91-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12344. | |
| UNC-2170 | UNC-2170 is a functionally active, fragment-like ligand for 53BP1 ( IC 50 =29 μM; K d =22 μM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1648707-58-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115531. | |
| UNC2250 | UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3. Uses: Scientific research. Group: Signaling pathways. CAS No. 1493694-70-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15797. | |
| UNC2383 | UNC2383 is an oligonucleotide enhancer compound. UNC2383 can enhance the efficacy of antisense oligonucleotides (ASOs) and splice-switching oligonucleotides (SSOs). UNC2383 can be used in research of diseases involving impaired oligonucleotide delivery, such as cystic fibrosis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2123481-48-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-157261. | |
| UNC2400 | UNC2400 is a close analog of UNC1999 with >1,000-fold lower potency than UNC1999 as a negative control for cell-based studies[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1433200-49-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12845. | |
| UNC3230 | UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1031602-63-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110150. | |
| UNC3474 | UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0?±?0.3 ?M. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1648707-79-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156906. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.