MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Abciximab | Abciximab (C7E3), a chimeric mouse/human monoclonal antibody fragment, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: C7E3. CAS No. 143653-53-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9934. |  |
| ABD957 | ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC50 of 0.21 ?M for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3007772-60-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142161. | |
| Abelacimab | Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MAA868. CAS No. 2098724-83-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99415. | |
| Abemaciclib | Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC 50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY2835219. CAS No. 1231929-97-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-16297A. | |
| Abemaciclib metabolite M18 hydrochloride | Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LSN3106729 hydrochloride. CAS No. 2704316-82-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126534A. | |
| Abemaciclib metabolite M2 | Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LSN2839567. CAS No. 1231930-57-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128669. | |
| Abemaciclib methanesulfonate | Abemaciclib methanesulfonate (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC 50 s of 2 nM and 10 nM for CDK4 and CDK6, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY2835219 methanesulfonate. CAS No. 1231930-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16297. | |
| Aβ42-IN-2 | Aβ42-IN-2 (compound example 36) is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the research of Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1914989-80-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-136866. | |
| Abexinostat | Abexinostat (CRA 024781) is a novel pan- HDAC inhibitor mostly targeting HDAC1 with K i of 7 nM. Abexinostat also inhibits metallo-β-lactamase domain-containing protein?2 ( MBLAC2 ) hydrolase activity with an EC 50 below 10 nM [1] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CRA 024781; PCI-24781. CAS No. 783355-60-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10990. | |
| ABH hydrochloride | ABH (hydrochloride) is an orally active arginase inhibitor ( K i = 8.5 nM). ABH hydrochloride promotes NO production and reduces the expression of inflammatory response-related molecules ( ICAM-1 , VCAM-1 , MCP-1 ). ABH hydrochloride improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Signaling pathways. CAS No. 194656-75-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112868B. | |
| Abietic acid | Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. CAS No. 514-10-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6871. | |
| Abiprubart | Abiprubart is an anti- CD40 human IgG4 κ monoclonal antibody [1]. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003). Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2765071-95-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990726. | |
| Abiraterone | Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC 50 s of 2.5 nM and 15 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CB-7598. CAS No. 154229-19-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-70013. | |
| Abiraterone acetate | Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. Abiraterone acetate is a proagent form of Abiraterone (CB7598). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CB7630. CAS No. 154229-18-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-75054. | |
| Abiraterone acetate (Standard) | Abiraterone acetate (Standard) is the analytical standard of Abiraterone acetate. This product is intended for research and analytical applications. Abiraterone acetate (CB7630) is an oral, potent, selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity. Abiraterone acetate is a proagent form of Abiraterone (CB7598). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CB7630 (Standard). CAS No. 154229-18-2. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-75054R. | |
| Abiraterone decanoate | Abiraterone decanoate is a potent Abiraterone proagent. Abiraterone decanoate provide a controlled release of Abiraterone and long-acting CYP17 inhibition with intramuscular (IM) delivery [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2486052-18-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145786. | |
| Abiraterone sulfate | Abiraterone sulfate is a metabolite of Abiraterone (HY-148377). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1993430-25-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-148375. | |
| Abituzumab | Abituzumab (DI17E6) is a humanised anti- integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK , Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: EMD 525797; DI17E6. CAS No. 1105038-73-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99183. | |
| ABM-14 | ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 (HY-130492) to degrade AR [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1973408-76-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131388. | |
| ABMA | ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses , intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 332108-65-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-124801. | |
| ABN401 | ABN401 is an orally active and selective ATP-competitive c-MET inhibitor with an IC 50 of 10 nM. ABN401 is cytotoxic to MET-addicted cancer cells with the IC 50 of 2-43 nM. ABN401 has bioavailability in rats and dogs of 42.1-56.2% and 27.4-37.7%, respectively. ABN401 has antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2242563-15-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147040. | |
| ABO hydrochloride | ABO hydrochloride is a potent modulator of ANXA7 as ABO binds to Thr286 of ANXA7 and inhibits its phosphorylation. ABO promotes autophagy via elevation of ANXA7 and triggering ANXA7 subcellular redistribution [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2309172-24-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-115635. | |
| ABP688 | ABP688 is a high affinity human mGluR5 antagonist with an K i of 1.7 nM. Radioisotope-labeled ABP688 can be used as a PET tracer for clinical imaging of the mGlu5 receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 924298-51-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110141. | |
| ABR-238901 | ABR-238901 is an orally active and potent S100A8/A9 blocker and inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). ABR-238901 has the potential for myocardial infarction (MI) research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1638200-22-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-141537. | |
| Abrilumab | Abrilumab is a fully human monoclonal antibody directed against α4β7. Abrilumab selectively binds the α4β7 integrin heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD) [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1342290-43-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99184. | |
| Abrocitinib | Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC 50 s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 ( IC 50 , 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-04965842. CAS No. 1622902-68-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107429. | |
| Abrucomstat | Abrucomstat (3-Nitroxypropanol) is an orally active methyl coenzyme M reductase inhibitor. Abrucomstat decreases ruminal methanogenesis[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 3-Nitroxypropanol; 3-NOP. CAS No. 100502-66-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139566. | |
| Abscisic acid | Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump ( H + -ATPase ) and leads to the plasma membrane depolarization in a Ca 2+ -dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)?-(+)?-Abscisic acid; ABA. CAS No. 21293-29-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-100560. | |
| (±)-Abscisic acid | (±)-Abscisic acid ((±)-ABA) is an orally active phytohormone. (±)-Abscisic acid induces Ca 2+ channel opening to facilitate the influx of calcium ions and modulates stomatal movement. (±)-Abscisic acid shows anti-inflammatory activity and has the potential for the research of inflammatory bowel disease (IBD) [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (±)-ABA. CAS No. 14375-45-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2549. | |
| Absinthin | Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46 , which reduces cytosolic Ca 2+ -rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46 [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 1362-42-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N0742. | |
| ABT-100 | ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation ( IC 50 s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 450839-40-4. Pack Sizes: 5 mg. Product ID: HY-119257. | |
| ABT-384 | ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 ( 11β-HSD1 ) inhibitor. ABT-384 exhibits high affinity ( K i 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimers disease (AD) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 868623-40-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111262. | |
| ABT-418 hydrochloride | ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 147388-83-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105170B. | |
| ABT-510 acetate | ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 acetate also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 acetate can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD) [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 442526-87-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-13545B. | |
| ABT-639 | ABT-639 is a novel, peripherally acting, selective T-type Ca 2+ channel blocker. Uses: Scientific research. Group: Signaling pathways. CAS No. 1235560-28-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19721. | |
| ABT-702 dihydrochloride | ABT-702 dihydrochloride is a potent adenosine kinase ( AK ) inhibitor ( IC 50 =1.7 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1188890-28-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103161. | |
| ABT-737 | ABT-737, a BH3 mimetic, is a potent Bcl-2 , Bcl-x L and Bcl-w inhibitor with EC 50 s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 852808-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50907. | |
| ABT-751 | ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on β-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis , thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E7010. CAS No. 141430-65-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13270. | |
| ABTL-0812 | ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: α-Hydroxylinoleic acid. CAS No. 57818-44-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-U00141. | |
| ABTS diammonium salt | ABTS diammonium salt (AzBTS-(NH4)2) is a substrate for horseradish peroxidase (HRP) conjugate. ABTS diammonium salt can be used to evaluate antioxidant capacity[1][2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: AzBTS-(NH4)2. CAS No. 30931-67-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-15902. | |
| AC 187 | AC 187 is a potent and orally active amylin receptor antagonist with an IC 50 of 0.48 nM and a K i of 0.275 nM. AC 187 shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 has neuroprotective effects [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 151804-77-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1393. | |
| Ac2-26 | Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKK? protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model[1][2][3][4]. Uses: Scientific research. Group: Peptides. CAS No. 151988-33-9. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-P1098. | |
| AC-261066 | AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 870773-76-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108532. | |
| AC-262536 | AC-262536 is a selective and non-steroidal androgen receptor modulators ( SARMs ) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor, with an affinity in the low nanomolar range (1-10 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 870888-46-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122025. | |
| AC-265347 | AC-265347 is a calcium-sensing receptor ( CaSR ) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pK B ) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253901-26-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-117851. | |
| AC-4-130 | AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1834571-82-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124500. | |
| Ac4GalNAz | Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Ac4GalNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 653600-56-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141128. | |
| Ac4GlcNAz | Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC). It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu(I)-catalyzed azide-alkyne cycloaddition conditions. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-azidoacetylglucosamine-tetraacylated. CAS No. 98924-81-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W039953. | |
| Ac4ManNAz | Ac4ManNAz can be taken up by cells and is an azide-containing metabolic glycoprotein labeling reagent that selectively modifies proteins. Commonly used for cell labeling, tracking and proteomic analysis. Ac4ManNAz contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1213701-11-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W728531. | |
| Ac5GalNTGc | Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research[1][2]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160109. | |
| AC710 | AC710 is a potent PDGFR inhibitor with K d s of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1351522-04-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13493. | |
| AC-73 | AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells[1]. AC-73 is also an anti-proliferative agent and an inducer of autophagy in leukemic cells[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 775294-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122214. | |
| Acacetin | Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3K&gamma. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 5,7-Dihydroxy-4'-methoxyflavone. CAS No. 480-44-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0451. | |
| Acalabrutinib | Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) [1] [2]. Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACP-196. CAS No. 1420477-60-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-17600. | |
| Ac-Ala-OH | Ac-Ala-OH is an endogenous metabolite. Ac-ALA-OH inhibits APEH. Ac-Ala-OH can be used in breast cancer research [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 97-69-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W004066. | |
| Acamprosate calcium | Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calcium N-acetylhomotaurinate. CAS No. 77337-73-6. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-17030. | |
| Acanthopanaxoside B | Acanthopanaxoside B is a triterpenoid saponin isolated from the leaves of Acanthopanax senticosus [1]. Uses: Scientific research. Group: Natural products. CAS No. 915792-03-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N4135. | |
| Acapatamab | Acapatamab (AMG-160) is an anti- CD3E/FOLH1 monoclonal antibody [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG-160. CAS No. 2314491-93-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99418. | |
| Acarbose | Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor ( IC 50 =11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: BAY g 5421. CAS No. 56180-94-0. Pack Sizes: 10 mM * 1 mL; 200 mg; 1 g. Product ID: HY-B0089. | |
| Acasunlimab | Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: GEN1046. CAS No. 2253937-12-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99419. | |
| ACBI1 | ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375564-55-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128359. | |
| ACBI2 | ACBI2 is a highly potent and orally active VHL PROTAC SMARCA2 degrader (EC50: 7?nM), which selectively degrades SMARCA2 with a DC50 value of 1?nM in RKO cells. ACBI2 can be used in the research of lung cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2913161-19-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151623. | |
| ACBI3 | ACBI3 (compound 7) is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (HY-162960) (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4-(ethynyloxy)butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995). ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2938169-76-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-157228. | |
| Ac-CoA Synthase Inhibitor1 | Ac-CoA Synthase Inhibitor1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 ?M[1]. Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus (RSV)[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 508186-14-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104032. | |
| Ac-DEVD-AFC | Ac-DEVD-AFC is a fluorogenic substrate (λ ex =400 nm, λ em =530 nm). Uses: Scientific research. Group: Peptides. CAS No. 201608-14-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1005. | |
| Ac-DEVD-AMC | Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm[1][2][3]. Uses: Scientific research. Group: Peptides. CAS No. 169332-61-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1003. | |
| Ac-DEVD-CHO | Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a K i value of 230 pM. Uses: Scientific research. Group: Peptides. CAS No. 169332-60-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1001. | |
| Ac-DEVD-pNA | Ac-DEVD-pNA is a ligand for caspase-3/-7 and related cysteine proteases[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 189950-66-1. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1006. | |
| ACDPP | ACDPP is a specific mGluR5 antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37804-11-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-103564. | |
| ACEA | ACEA (short for arachidonyl-2'-chloroacetamide) is a synthetic organic compound that acts as an agonist of the cannabinoid receptor CB1. It is a chemical that affects the endocannabinoid system in the body, which regulates various physiological processes such as appetite, pain perception, mood, and memory [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Arachidonyl-2-chloroethylamide. CAS No. 220556-69-4. Pack Sizes: 5 mg (68.31 mM * 200 μL in Methyl acetate); 10 mg (68.31 mM * 400 μL in Methyl acetate); 25 mg (68.31 mM * 1 mL in Methyl acetate); 50 mg (68.31 mM * 2 mL in Methyl acetate). Product ID: HY-110004. | |
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