BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Dp44mT | Dp44mT is a potent iron chelator, which shows selective antitumor activity. Synonyms: 2-(Di(pyridin-2-yl)methylene)-N,N-dimethylhydrazinecarbothioamide; 2,N-dimethylsemicarbazone; Hydrazinecarbothioamide, 2-(di-2-pyridinylmethylene)-N,N-dimethyl-; Di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone; 3-[bis(2-pyridyl)methyleneamino]-1,1-dimethyl-thiourea; 2-[di(Pyridin-2-yl)methylidene]-N,N-dimethylhydrazinecarbothioamide; NSC744381. Grades: 98%. CAS No. 152095-12-0. Molecular formula: C14H15N5S. Mole weight: 285.37. |  |
| DPY0801 | DPY0801 is a useful intermediate for chemical synthesis of a number of biologically important molecules, including porphyrins, anticancer drugs, bile pigments, photosensitizers and so on. Uses: Dpy0801 is a useful intermediate for chemical synthesis of a number of biologically important molecules. Synonyms: DPY-0801; DPY 0801; DPY0801; Dibenzyl 4,4'-methylenebis(3,5-dimethyl-1H-pyrrole-2-carboxylate). Grades: 98%. CAS No. 68500-80-1. Molecular formula: C29H30N2O4. Mole weight: 470.57. | |
| DPY3704 | DPY3704 is a useful intermediate for chemical synthesis of a number of biologically important molecules, including bile pigments, porphyrins, photosensitizers and anticancer drugs and so on. Uses: Dpy3704 is a useful intermediate for chemical synthesis of a number of biologically important molecules, including bile pigments, porphyrins, photosensitizers and anticancer drugs and so on. Synonyms: DPY-3704; DPY 3704; (Z)-5-((3,4-dimethyl-1H-pyrrol-2-yl)methylene)-3,4-dimethyl-1,5-dihydro-2H-pyrrol-2-one. Grades: 98%. CAS No. 65113-70-4. Molecular formula: C13H16N2O. Mole weight: 216.28. | |
| DPY9309 | DPY9309 is a useful intermediate for chemical synthesis of a number of biologically important molecules, including porphyrins and N-confused porphyrin. It is a photosensitizer and used as an anticancer drug. Synonyms: DPY 9309; DPY-9309; 4,4'-Methylenebis(5-methyl-1H-pyrrole-2-carbaldehyde). Grades: 98%. CAS No. 511529-30-9. Molecular formula: C13H14N2O2. Mole weight: 230.27. | |
| D-Quinovosamine hydrochloride | D-Quinovosamine hydrochloride, an extensively applied pharmaceutical compound in the biomedical sector, showcasing remarkable antimicrobial characteristics, rendering it highly efficacious in stduying diverse bacterial infections. Its mechanism of action centers around the inhibition of bacterial cell wall synthesis, consequently thwarting their proliferation and survival. Synonyms: 2-Amino-2,6-dideoxy-D-glucopyranose; 6-Deoxy-D-glucosamine. CAS No. 6189-58-8. Molecular formula: C6H13NO4 HCl. Mole weight: 199.63. | |
| D-Rhamnose | D-Rhamnose is a naturally existing sugar sith multifunctional attributes encompassing anti-inflammatory and antibacterial properties. It can be used to study bacterial infections and diminish swelling affiliated with specific circumstances. Synonyms: 6-Deoxy-D-mannose; D-D-Mannomethylose. CAS No. 634-74-2. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| D-Ribitol-5-phosphate | D-Ribitol-5-phosphate, a pivotal intermediate in the biosynthesis of various biomolecules, assumes a crucial function in cellular metabolism. Its involvement extends to pathways associated with nucleotide, vitamin, and coenzyme synthesis. Moreover, its indispensability arises in treating specific inborn metabolic disorders, rendering it a potential therapeutic remedy for diverse ailments. Synonyms: L-Ribitol 1-phosphate. CAS No. 35320-17-3. Molecular formula: C5H13O8P. Mole weight: 232.13. | |
| D-Ribonic acid-1,4-lactone | It is a sugar lactone as an inhibitor of β-galactosidase of E. coli. Synonyms: D-(+)-Ribonic acid-gamma-lactone; D-Ribono-1,4-lactone; D-Ribonolactone; D-(+)-Ribonic Acid γ-Lactone; D-(+)-Ribonolactone; NSC 1031; (3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one. Grades: ≥97% by HPLC. CAS No. 5336-8-3. Molecular formula: C5H8O5. Mole weight: 148.11. | |
| D-Ribopyranosyl thiosemicarbazide | D-Ribopyranosyl thiosemicarbazide is a bioactive compound showcasing profound potential in counteracting viral menaces, evoking a triumphant stance against viral afflictions. Synonyms: 2-(D-Ribopyranosyl)-hydrazinecarbothioamide. CAS No. 95352-77-5. Molecular formula: C6H13N3O4S. Mole weight: 223.25. | |
| D-Ribose-1-phosphate bis(cyclohexylammonium) salt | D-Ribose-1-phosphate bis(cyclohexylammonium) salt is a pivotal compound extensively utilized in the biomedical sector, serving as an indispensable precursor to a multitude of biologically dynamic molecules intricately intertwined with cellular metabolism. Its paramountcy lies in facilitating the synthesis of nucleotides and nucleic acids, thereby providing researchs for genetic disorders and ailments stemming from comapplicationd nucleotide metabolism. CAS No. 58459-37-3. Molecular formula: C5H11O8P 2C6H13N. Mole weight: 428.46. | |
| D-Ribose-5-phosphate barium salt hexahydrate | D-Ribose-5-phosphate barium salt hexahydrate, a pivotal compound utilized in the biomedical sector, holds immense academic and scientific significance. It assumes a crucial function in addressing specific hereditary ailments linked to carbohydrate metabolism. Manifesting as a forerunner for nucleotides, this product actively engages in imperative cellular proceedings. CAS No. 15673-79-7. Molecular formula: C5H9BaO8P 6H2O. Mole weight: 473.51. | |
| D-Ribose-5-phosphate disodium salt hydrate | D-Ribose-5-phosphate disodium salt hydrate is a pivotal biomolecule extensively utilized in the biomedical sector, showcasing remarkable enzymatic attributes while serving as a pivotal participant in nucleotide and nucleic acid biosynthesis. It finds extensive application as a precursor in DNA and RNA synthesis. Synonyms: D-Ribofuranose 5-phosphate disodium salt hydrate. CAS No. 18265-46-8. Molecular formula: C5H9Na2O8P H2O. Mole weight: 274.07. | |
| D-Ribulose 5-phosphate sodium salt | D-Ribulose 5-phosphate sodium salt is a pivotal intermediate in the intricate pentose phosphate pathway, playing a paramount role in research of metabolic intricacies. As an inherent substrate, this compound fearlessly partakes in diverse enzymatic reactions, steering the synthesis of vital biomolecules. Synonyms: Ru-5-P; erythro-Pentulose 5-phosphate. CAS No. 352525-12-3. Molecular formula: C5H11O8P xNa. Mole weight: 230.11 (free acid basis). | |
| D-Ribulose - Aqueous solution | D-Ribulose - Aqueous solution is a vital component used in the biomedical industry. It serves as a key ingredient for medicines targeting respiratory diseases and also aids in drug development related to cardiovascular disorders like hypertension and atherosclerosis. Synonyms: D-Adonose; D-erythro-2-Ketopentose; D-erythro-2-Pentulose; D-Arabinulose; D-Araboketose. CAS No. 488-84-6. Molecular formula: C5H10O5. Mole weight: 150.13. | |
| Drinidene | Drinidene is a bio-active chemical compound. Synonyms: 2-(Aminomethylene)-1-indanone; NSC-299237; CP-24877; CP24877; CP 24877; 1H-Inden-1-one, 2-(aminomethylene)-2,3-dihydro-. Grades: 98%. CAS No. 53394-92-6. Molecular formula: C10H9NO. Mole weight: 159.18. | |
| D-Sedoheptulose | D-Sedoheptulose, renowned for its potential in treating an array of maladies such as cancer, diabetes, and inflammation, yields a panoply of benefits. First and foremost, this rare sugar has the capacity to thwart tumor proliferation and curtail glucose regulation. Excitingly, D-Sedoheptulose impressively re-calibrates the immune system and imbues anti-inflammatory effects. With such standout characteristics, the future may bode well for D-Sedoheptulose's prospects as a sought-after future drug. Synonyms: D-altro-2-Heptulose. CAS No. 3019-74-7. Molecular formula: C7H14O7. Mole weight: 210.18. | |
| D-Sedoheptulose-2,3,4,5,6,7-13C6 | | |
| D-Sedoheptulose-7-phosphate barium salt | D-Sedoheptulose-7-phosphate barium salt is an essential biomedical agent, emerging as a pivotal catalyst across multifarious ailments. Embracing an indispensible role in the intricate orchestration of metabolic pathways and carbohydrate metabolism, its application extends to the research of enigmatic conditions like diabetes, metabolic syndrome, and glycolysis-related afflictions. Synonyms: D-SEDOHEPTULOSE-7-PHOSPHATE BARIUM SALT; J-016442. Molecular formula: C7H13O10PBa. Mole weight: 425.47. | |
| D-Sedoheptulose-7-phosphate barium salt-2,3,4,5,6,7-13C6 | | |
| D-Sedoheptulose 7-phosphate lithium salt | D-Sedoheptulose 7-phosphate lithium salt is a pivotal compound assuming a paramount role in studying intricate metabolic pathways linked to malignant neoplasms and glucose mishandling disorders. Synonyms: D-altro-Heptulose 7-phosphate lithium salt. Molecular formula: C7H15O10P xLi. Mole weight: 290.16 (free acid basis). | |
| DSM265 | DSM265 is a selective DHODH (dihydroorotate dehydrogenase) inhibitor used for prevention and treatment of malaria. DSM265 is highly selective toward DHODH of the malaria parasite Plasmodium. It is efficacious against both blood and liver stages of P. falciparum and active against drug-resistant parasite isolates. Treatment for malaria was in phase II clinical trials. Uses: Malaria. Synonyms: DSM265; DSM-265; DSM 265; UNII-0Q42P4YI6B; 0Q42P4YI6B; CHEMBL1956285; SCHEMBL14053411;2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine. Grades: 98%. CAS No. 1282041-94-4. Molecular formula: C14H12F7N5S. Mole weight: 415.34. | |
| D-Sorbitol hexaacetate | D-Sorbitol hexaacetate, a chemical compound, functions as a pharmaceutical excipient in drug formulations, improving active pharmaceutical ingredient solubility and stability. Its potential anti-inflammatory and analgesic properties suggest efficacy in treating various inflammatory disorders. Unleashing the benefits of D-Sorbitol hexaacetate as a pharmaceutical excipient empowers medical research and drives drug development towards new heights. CAS No. 7208-47-1. Molecular formula: C18H26O12. Mole weight: 434.39. | |
| D-Sorbitol hexahydrate | D-Sorbitol hexahydrate is a sugar alcoho acting as an excipient in pharmaceutical preparations, notably oral compounds and syrups. Molecular formula: C6H14O6 6H2O. Mole weight: 290.26. | |
| D-Sorbose | D-Sorbose is a carbohydrate compound with potential efficacy in studyting metabolic disorders such as diabetes and obesity. Synonyms: D-Xylo-hexulose. CAS No. 3615-56-3. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| D-Tagatose 1-phosphate | D-Tagatose 1-phosphate is a multifunctional compound for studying viral infections. It has exhibited its prowess as a pivotal intermediate in the synthesis of versatile chemical compounds, including potent antiviral compounds. Molecular formula: C6H13O9P. Mole weight: 260.14. | |
| D-Tagatose-6-phosphate barium salt | | |
| D-Tagatose-6-phosphate lithium salt | D-Tagatose-6-phosphate lithium salt is a bacterial strain that belongs to the group of polyols. D-Tagatose 6-phosphate is a substrate for tagatose-6-phosphate kinase which converts it into D-tagatose 1,6-bisphosphate with the transfer of a phosphate from ATP. Synonyms: D-Tagatofuranose 6-phosphate lithium salt. CAS No. 73544-42-0. Molecular formula: C6H13O9P.xLi. Mole weight: 260.14 (free acid). | |
| D-Talitol | D-Talitol, a remarkably versatile sugar alcohol, finds extensive application as an excipient in diverse pharmaceutical formulations. Renowned for its profound efficacy in augmenting the flavor of oral drugs, it frequently serves as an agent to enhance the taste of chewable tablets and syrups to facilitate greater palatability. Moreover, D-Talitol assumes a pivotal role in the synthetic fabrication of numerous bioactive compounds, thereby showcasing its indispensable role in combating an assortment of diseases. Synonyms: D-Altritol. CAS No. 643-03-8. Molecular formula: C6H14O6. Mole weight: 182.17. | |
| D-Talitol-1,6-diphosphate | | |
| D-Talono-1,4-lactone | D-Talono-1,4-lactone is an indispensable compound for the research of Alzheimer's, Parkinson's and diverse neurodegenerative maladies, intricately operating as a neuroactivity modifier. Synonyms: d-talono-1,4-lactone; 5-(1,2-dihydroxyethyl)-3,4-dihydroxyoxolan-2-one; 23666-11-7; 10238-03-6.gamma.-D-Galactonolactone; Gulono-1,4-lactone; D-Allonic acid gamma-lactone; D-Idonic acid, gamma-lactone; D-Galactonic acid, gamma-lactone; 5-(1,2-Dihydroxy-ethyl)-3,4-dihydroxy-dihydro-furan-2-one.gamma.-Lactone of mannonic acid; D-Mannonic acid. gamma.-lactone; D-Galactonic acid. gamma.-lactone; 1,4-D-Gulonolactone; 29474-78-0; C6H10O6; D-Allono-1,4-lactone; L-Gulonic acid g-lactone; Gulonic acid-1,4-lactone; D-Gulonic acid-1,4-lactone; NSC-1971; Mannonic acid, D-; Galactonic acid, D-; glucono-1,4-lactone; 1,4-D-Mannonolactone; D-Galactono-.gamma.-lactone. CAS No. 23666-11-7. Molecular formula: C6H10O6. Mole weight: 178.14. | |
| D-(+)-Threitol | D-(+)-Threitol is a multifaceted commodity extensively adopted realm, used for studying diverse afflictions such as diabetes, cardiovascular maladies and neurodegenerative states. Synonyms: (2R,3R)-1,2,3,4-Butanetetrol. Grades: ≥98%, ≥95%e.e. CAS No. 2418-52-2. Molecular formula: C4H10O4. Mole weight: 122.12. | |
| (+)-D-threo-PDMP hydrochloride | (+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP. (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase. Synonyms: d-threo-PDMP; 109836-82-0; 80938-69-8; (+)-D-threo-PDMP (hydrochloride); DL-threo-PDMP (hydrochloride); 139889-62-6; N-[(1R,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]decanamide; hydrochloride; N-[(1R,2R)-2-Hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride; SMR000326846; DL-threo-PDMP; (+/-)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride; D-Threo-pdmp-HCl; MLS000859987; MLS002153295; BML3-D11; CHEMBL1255585; EX-A8002H; DTXSID401017468; D-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL; AKOS040755898; J-002336; D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol*HCl; N-((1R,2R)-1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide hydrochloride; Decanamide,N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-,hydrochloride(1:1),rel-. Grades: ≥98%. CAS No. 139889-62-6. Molecular formula: C23H38N2O3·HCl. Mole weight: 427.03. | |
| D-threo-PPMP hydrochloride | D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor, which is the active enantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP. In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growth in vitro at 20 μM and significantly inhibits DNA synthesis at 3 μM. Synonyms: D-threo-1-phenyl-2-Palmitoylamino-3-morpholino-1-propanol; [R-(R*,R*)]-N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-hexadecanamide, monohydrochloride. Grades: ≥98%. CAS No. 139889-65-9. Molecular formula: C29H50N2O3·HCl. Mole weight: 511.2. | |
| D-Threose | D-Threose is an intriguing carbohydrate compound, exhibiting promising potential in studying both diabetes and obesity. Notably, its distinctive structural configuration renders it a viable building unit for drug synthesand design. Synonyms: D-(-)-Threose. CAS No. 95-43-2. Molecular formula: C4H8O4. Mole weight: 120.1. | |
| D-Thyroxine | D-Thyroxine is the dextrorotary isomer of thyroxine with antihyperlipidemic activity. It stimulates the formation of low-density lipoprotein (LDL) and increases the catabolism of LDL thereby leading to increased excretion of cholesterol and bile acids via the biliary route. It is released from thyroglobulin by proteolysis and secreted into the blood. It is one of the thyroid hormones involved in the maintenance of metabolic homeostasis and has been used to treat hyperlipidemia. It is used as an cholesterol-lowering drug but was pulled due to cardiac side-effects. It also increases hepatic lipase which in turn improves utilization of triglycerides, improving apolipoprotein E cholesterol particles. Uses: D-thyroxin is one of the thyroid hormones involved in the maintenance of metabolic homeostasis and has been used to treat hyperlipidemia. it is used as an cholesterol-lowering drug. Synonyms: Dextrothyroxine; Choloxin; Dextrothyroxinum; (R)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoic acid; Biotirmone; Debetrol; D-T4; O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine. Grades: 95%. CAS No. 51-49-0. Molecular formula: C15H11I4NO4. Mole weight: 776.87. | |
| DTP348 | DTP348 is an oral dual CAIX inhibitor/ radiosensitizer. DTP348 is an oral dual drug with two mechanisms of action: (1) carbonic anhydrase IX inhibitor which acidifies the intracellular pH through the sulfamide components; (2) radio sensitizer of hypoxic cells through its 5-nitroimidazole moiety. Synonyms: DTP 348; DTP-348; 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethylsulfamide; 1-(2-Sulfamidoethyl)-2-methyl-5-nitroimidazole. CAS No. 1383370-92-0. Molecular formula: C6H11N5O4S. Mole weight: 249.24. | |
| Ducheside A pentaacetate | | |
| D-[UL-13C6; 15N]Glucosamine HCl | | |
| D-[UL-13C6]Glucosamine HCl | D-[UL-13C6]Glucosamine HCl is a distinctive modified version of glucosamine, prevalently prescribed for the research of osteoarthritis. The incorporation of stable carbon isotopes within this compound unequivocally elicits indispensable contributions towards metabolic investigation and analysis pertaining to pharmaceutical drug assimilation. Molecular formula: 13C6H13NO5 HCl. Mole weight: 221.59. | |
| Dulcitol | Dulcitol is a saccharitol synthesized from diverse botanical origins, manifesting imbued potential for pharmaceutical and nutraceutical applications. Synonyms: Galactitol. CAS No. 608-66-2. Molecular formula: C6H14O6. Mole weight: 182.17. | |
| Duloxetine-4-hydroxy-D-glucuronide | | |
| DuP-697 | DuP-697 is a selective COX-2 inhibitor. Synonyms: DuP-697; DuP 697; DuP697; S-6907; S 6907; S6907; BFMT; 5-bromo-2-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-thiophene. CAS No. 88149-94-4. Molecular formula: C17H12BrFO2S2. Mole weight: 411.3. | |
| dupilumab | Cas No. 1190264-60-8. | |
| DWN-10899 | DWN-10899 is a potent and selective Nav1.7 blocker which is orally available. Study showed that it could significantly blocks neuropathic pain in mouse momdel. Synonyms: DWN 10899; DWN10899. | |
| D-Xylonic acid-1,4-lactone | D-Xylonic acid-1,4-lactone is a highly versatile and potent biomedical compound acting as a stellar antioxidant, efficacious anti-inflammatory and commendable antimicrobial role. It has inhibitory efficacy in the research of ailments such as diabetes, cardiovascular afflictions and diverse infections. Synonyms: D-Xylono-1,4-lactone; D-Xylonic acid gamma-lactone. CAS No. 15384-37-9. Molecular formula: C5H8O5. Mole weight: 148.11. | |
| D-Xylonic acid ammonium salt | D-Xylonic acid ammonium salt is an intriguing compound, showcasing remarkable promise in the research of metabolic disorders. This compound manifests as an invaluable biochemical precursor, while simultaneously lending itself as a pivotal entity in pharmaceutically driven investigations. Synonyms: Ammonium-D-xylonate. CAS No. 5461-96-1. Molecular formula: C5H9O6 NH4. Mole weight: 183.16. | |
| D-Xylonic acid calcium salt hydrate | D-Xylonic acid calcium salt hydrate is a compound product used in the research of calcium-related disorders serving as a calcium supplement. Synonyms: Calcium D-xylonate hydrate. CAS No. 72656-08-7. Molecular formula: C10H18O12 Ca xH2O. Mole weight: 370.32 (anydrous basis). | |
| D-Xylose-1-phosphate | D-Xylose-1-phosphate is an imperative biochemical assuming a pivotal role in the research of disorders correlated with metabolic irregularities and genetic anomalies. It acts as a substrate for an array of enzymes engaged in energy generation. CAS No. 25799-81-9. Molecular formula: C5H11O8P. Mole weight: 230.11. | |
| D-Xylose-BSA | | |
| D-Xylose - Syrup | | |
| D-Xylulose - Aqueous solution | D-Xylulose, an aqueous solution, serves as a vital biomedical component and enjoys widespread adoption within the realms of research and pharmaceutical industries. Renowned for its utility in the creation of therapeutic medications targeting metabolic disorders and diabetes, this solution assumes the role of a potent precursor leading to the synthesis of indispensable biomolecules. CAS No. 551-84-8. Molecular formula: C5H10O5. Mole weight: 150.13. | |
| Dynamin inhibitory peptide, myristoylated (control) | | |
| Dynasore | Dynasore is a cell-permeable and noncompetitive inhibitor of the GTPase activity of dynamin with IC50 value of 15 μM. Synonyms: Dynasore. Grades: >98%. CAS No. 304448-55-3. Molecular formula: C18H14N2O4. Mole weight: 322.31. | |
| Dyngo-4a | Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1?μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively. Synonyms: Hydroxy-Dynasore; 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[ (2, 4, 5-trihydroxyphenyl) Methylene]hydrazide; 3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide; Dyngo 49. Grades: ≥96%. CAS No. 1256493-34-1. Molecular formula: C18H14N2O5. Mole weight: 338.31. | |
| Dynole 34-2 | Dynole 34-2 is a dynamin I inhibitor with IC50 value of 1.3 μM. It also inhibits receptor-mediated endocytosis (RME) with IC50 value of 5.0 μM. Synonyms: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide. Grades: ≥99% by HPLC. CAS No. 1128165-88-7. Molecular formula: C25H36N4O. Mole weight: 408.58. | |
| E3330 | E3330 is a potent and selective APE1 (Ref-1) inhibitor, which inhibits NF-κB DNA-binding activity. It blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines and has anticancer properties such as inhibiting the growth and migration of cancer cells. Synonyms: APX-3330; E-3330; E 3330; (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid; (E)-2-((4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoic acid; Undecanoic acid, 2-((4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene)-, (E)-. Grades: 98%. CAS No. 136164-66-4. Molecular formula: C21H30O6. Mole weight: 378.46. | |
| E6201 | E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers. Synonyms: E6201; E 6201; E-6201; ER 806201; ER806201; ER-806201; LL-Z1640-2. CAS No. 603987-35-5. Molecular formula: C21H27NO6. Mole weight: 389.45. | |
| E7016 | E7016 is an inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemo- and/or radiosensitizing activity. PARP inhibitor E7016 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. In addition, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. Synonyms: E 7016; E-7016; 10-((4-Hydroxypiperidin-1-yl)methyl)chromeno[4,3,2-de]phthalazin-3(2H)-one. Grades: ≥98%. CAS No. 902128-92-1. Molecular formula: C20H19N3O3. Mole weight: 349.39. | |
| E 7820 | E7820 is an orally active unique angiogenesis inhibitor that inhibits the expression of integrin α2 subunit on endothelial cells and has antiangiogenic and antitumor activities. E7820 regulates the expression of α-1, α-2, α-3 and α-5 integrin mRNA, and inhibits rat aortic angiogenesis with an IC50 of 0.11 μg/mL. Synonyms: ER68203-00; N-(3-Cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide; NSC-719239; 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide; Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-. Grades: ≥95%. CAS No. 289483-69-8. Molecular formula: C17H12N4O2S. Mole weight: 336.37. | |
| E7974 | E7974 is an analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule assembly; depolymerization of exsiting microtubules; inhibition of mitosis; and inhibition of cellular proliferation. This agent may have more affinity for the beta-3 tubulin isotype. Synonyms: E 7974; E-7974; (S,E)-4-((S)-2-((R)-1-isopropylpiperidine-2-carboxamido)-N,3,3-trimethylbutanamido)-2,5-dimethylhex-2-enoic acid. CAS No. 610787-07-0. Molecular formula: C24H43N3O4. Mole weight: 437.62. | |
| EAD-1 | EAD-1, a chloroquinoline derivative, has been found to be an autophagy inhibitor that exhibit antiproliferative effct in lung and pancreatic cancer cells so that could be significant in anticancer studies. Synonyms: EAD1; EAD-1; EAD 1; N1-((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-N2-(2-((7-chloroquinolin-4-yl)amino)ethyl)-N2-methylethane-1,2-diamine. Grades: 98%. CAS No. 1644388-26-0. Molecular formula: C24H27Cl2N7. Mole weight: 484.43. | |
| EAD-1 TFA | EAD-1 is a potent and selective inhibitor of autophagy (IC50 = 5.8 μM in the BxPC3 cells) with antiproliferative activity in lung and pancreatic cancer cells. Synonyms: N-[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl]-N'-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N'-methylethane-1,2-diamine;2,2,2-trifluoroacetic acid. Grades: ≥98%. Molecular formula: C26H28Cl2F3N7O2. Mole weight: 598.45. | |
| EC-17 | EC17, also known as Folate-FITC, is a conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity. Folate-FITC binds to folate receptors, which are overexpressed on the surfaces of many cancer cells including kidney and ovarian cancer cells. Once bound to the cancer cell through the folate moiety of the conjugate, curculating anti-fluorescein antibodies.may recognize and bind to the FITC moiety, resulting in antibody-dependent cellular cytotoxicity. Synonyms: EC17; EC 17; Folate-FITC; Folate-fluorescein conjugate. CAS No. 583037-91-6. Molecular formula: C42H36N10O10S. Mole weight: 872.87. | |
| Ecothiophate iodide | Ecothiophate iodide is a potent, long-acting cholinesterase inhibitor. It covalently binds by its phosphate group to serine group at the active site of the cholinesterase. It binds irreversibly to cholinesterase. It is used as an ocular antihypertensive in the treatment of chronic glaucoma and accommodative esotropia in some cases. It is also an anticholinesterase drug and used as a miotic. It has been listed. Uses: Ecothiophate iodide is used as an ocular antihypertensive in the treatment of chronic glaucoma and accommodative esotropia in some cases. it is also an anticholinesterase drug and used as a miotic. Synonyms: 2-[ (Diethoxyphosphinyl) thio]ethanaminium iodide; Phospholine iodide; N- (2- (Diethoxyphosphinylthio) ethyl) trimethylammonium iodide; Ethanaminium, 2-((diethoxyphosphinyl)thio)-N,N,N-trimethyl-, iodide. Grades: 98%. CAS No. 513-10-0. Molecular formula: C9H23INO3PS. Mole weight: 383.23. | |
| Edatrexate | Edatrexate is a polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Uses: Antineoplastic agents. Synonyms: 10-ethyl-deaza-aminopterin; 10-EDAM; 10 EDAM; 10EDAM; CGP-30694; CGP30694; CGP30694; D 03942; D-03942; D03942. CAS No. 80576-83-6. Molecular formula: C22H25N7O5. Mole weight: 467.49. | |
| Edotecarin | Edotecarin is a synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. Synonyms: J 107088; PF 804950; 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12-β-D-glucopyranosyl-12,13-dihydro-2,10-dihydroxy-6-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-; 6-[(1,3-Dihydroxy-2-propanyl)amino]-12-(β-D-glucopyranosyl)-2,10-dihydroxy-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. Grades: ≥95%. CAS No. 174402-32-5. Molecular formula: C29H28N4O11. Mole weight: 608.56. | |
| Edrecolomab | Edrecolomab is a murine monoclonal antibody targeting the cell-surface glycoprotein EpCAM (17-1A), which is expressed on epithelial tissues and on various carcinomas. Edrecolomab may be used in the adjuvant treatment of patients with resected stage III colon cancer. Synonyms: MAb17-1A; Panorex. CAS No. 156586-89-9. | |
| (E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)amino)quinazolin-6-yl)allyl)carbamate | Cas No. 537705-08-1. | |
| EHNA hydrochloride | EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM) and also an inhibitor of adenosine deaminase. EHNA inhibits spontaneous differentiation of human ESCs in feeder-free conditions and directed neuronal differentiation. Uses: Antiviral agents. Synonyms: (2S,3R)-3-(6-aminopurin-9-yl)nonan-2-ol hydrochloride. Grades: >98%. CAS No. 58337-38-5. Molecular formula: C14H23N5O.HCl. Mole weight: 313.83. | |
| EHT-6706 | EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more than 60 human tumor cell lines, even those described as being drug resistant. EHT 6706 also shows strong efficacy as a vascular-disrupting agent, since it prevents endothelial cell tube formation and disrupts pre-established vessels, changes the permeability of endothelial cell monolayers and inhibits endothelial cell migration. Genome-wide transcriptomic analysis of EHT 6706 effects on human endothelial cells shows that the antiangiogenic activity elicits gene deregulations of antiangiogenic pathways. These findings indicate that EHT 6706 is a promising tubulin-binding compound with potentially broad clinical antitumor efficacy. Synonyms: EHT6706; EHT 6706; EHT-6706. CAS No. 1351592-10-3. Molecular formula: C21H24N2O4. Mole weight: 368.43. | |
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