BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Filociclovir | Filociclovir is a broad-spectrum anti-herpesvirus compound with good antiviral activity against cytomegalovirus (CMV), herpes simplex virus (HHV)-6 and HHV-8, with EC50 values ranging from 0.7 μM to 8 μM. Uses: Filociclovir is antiviral drug candidate and is used for the treatment of cytomegalovirus infection. Synonyms: Cyclopropavir; ZSM-I-62; MBX-400; 2-Amino-9-[ (Z) -[2, 2-bis (hydroxymethyl) cyclopropylidene]methyl]-3H-purin-6-one; (Z) -2-amino-9- ( (2, 2-bis (hydroxymethyl) cyclopropylidene) methyl) -1, 9-dihydro-6H-purin-6-one; (Z) -9- ( (2, 2-bis- (Hydroxymethyl) cyclopropylidene) methyl) guanine; (Z) -2-amino-9- ( (2, 2-bis (hydroxymethyl) cyclopropylidene) methyl) -1H-purin-6 (9H) -one. Grades: 98%. CAS No. 632325-71-4. Molecular formula: C11H13N5O3. Mole weight: 263.26. |  |
| Fimaporfin | Fimaporfin, a potent chlorin-based photosensitizer, is consisted of a mixture of three isomers A, B and C (25%,50%,25%). Fimaporfin has been developed by di-imide reduction of disulfonated tetraphenyl porphine (TPPS(2a)). The synthesized TPCS(2a) contains 3 isomers as shown by HPLC with low inter-batch variation with respect to isomer formation, less than 0.5% (w/w) of the starting material TPPS(2a) and absorbs light at 652nm. TPCS(2a) was found to be a clinically suitable PCI photosensitizer for photochemical activation of molecules that do not readily penetrate the cellular plasma membrane. Synonyms: Benzenesulfonic acid, 4,4'-[7,8(or 17,18)-dihydro-10,15(or 15,20)-diphenyl-21H,23H-porphine-5,20(or 5,10)-diyl]bis-; 4,4'-[7,8(or 17,18)-Dihydro-10,15(or 15,20)-diphenyl-21H,23H-porphine-5,20(or 5,10)-diyl]bis[benzenesulfonic acid]. CAS No. 1443547-43-0. Molecular formula: C132H96N12O18S6. Mole weight: 2330.63. | |
| Firtecan pegol | Firtecan pegol, also known as EZN-2208,Pegylated SN-38, or PEG-SN38, is a water-soluble polyethyleneglycol-SN38 conjugate. In vitro, the IC50 of EZN-2208 ranged from 3-24 nM, which was 30- to 45-fold lower than CPT-11 or 2.5- to 3.5-fold higher than SN38. In both an early-disease Raji model and an advanced-disease Daudi model, treatment with multiple doses of EZN-2208 resulted in 90% and 100% cures of animals, respectively (cure defined as no sign of tumors by gross observations at the termination of study). The activity of EZN-2208 was dramatically superior to that of CPT-11 in all three models. The excellent therapeutic efficacy of EZN-2208 in several B-cell NHL xenograft models merits its evaluation in the clinic for lymphoid malignancies. Synonyms: EZN-2208 (Pegylated SN-38). PEG-SN38, Firtecan pegol. CAS No. 946062-05-1. Molecular formula: C118H122N12O37. Mole weight: 2300.321. | |
| FK330 dihydrate | FK330 dihydrate is a novel inducible nitric oxide synthase inhibitor. It could prevent ischemia and reperfusion injury in rat liver transplantation. Uses: Fk330 dihydrate could prevent ischemia and reperfusion injury in rat liver transplantation. Synonyms: FR260330 dihydrate; FR 260330 dihydrate; FR-260330 dihydrate; FK-330 dihydrate; FK 330 dihydrate. Grades: 98%. CAS No. 682813-92-9. Molecular formula: C29H32ClF3N6O6. Mole weight: 653.05. | |
| FK 3311 | FK 3311 is a selective COX-2 inhibitor. Synonyms: FK-3311; FK3311. CAS No. 116686-15-8. Molecular formula: C15H13F2NO4S. Mole weight: 341.33. | |
| Fletikumab | Fletikumab is a monoclonal antibody that targets IL-20. Fletikumab can be used for the treatment of rheumatoid arthritis. Synonyms: NNC 0109-0012. CAS No. 1357158-22-5. | |
| FLLL31 | Cas No. 52328-97-9. | |
| Flopropione | Flopropione is a spasmolytic or antispasmodic agent, and acts as a 5-HT1A receptor antagonist. Synonyms: 2',4',6'-Trihydroxypropiophenone; Pasmus; Argobyl; Ecapron; Labroda; Cospanon. Grades: >98%. CAS No. 2295-58-1. Molecular formula: C9H10O4. Mole weight: 182.17. | |
| Floxacrine | Floxacrine is drug candidate for chemoprophylaxis of malaria. It is also a particular anthelminthic drug derived from quinacrine. Uses: Floxacrine is drug candidate for chemoprophylaxis of malaria. it is also a particular anthelminthic drug derived from quinacrine. Synonyms: HOE-991; Floxacrina; Floxacrinum; 7-Chloro-3,4-dihydro-10-hydroxy-3-[p-(trifluoromethyl)phenyl]-1,9(2H,10H)-acridinedione. Grades: 98%. CAS No. 53966-34-0. Molecular formula: C20H13ClF3NO3. Mole weight: 407.77. | |
| Fluciclatide F-18 | Fluciclatide-F18 is a radiopharmaceutical compound of a small synthetic cyclic peptide containing an RGD-sequence (Arg-Gly-Asp) labeled with the positron-emitting isotope fluorine F 18 that may be used to selectively image tumor cells and tumor vasculature by PET imaging. The RGD motif of fluciclatide F 18 selectively binds to the alphaVbeta3 integrin receptor, commonly upregulated on the surfaces of tumor cells and endothelial cells of tumor vasculature. This agent may be of use in visualizing and quantifying the development of tumor vascularity in response to antiangiogenic agents. Synonyms: [18F]AH111585; 18F-Fluciclatide; Fluciclatide (f-18). CAS No. 879894-01-6. Molecular formula: C75H115FN18O27S3. Mole weight: 1815.02. | |
| Fluconazole Beta-D-Glucuronide | A derivative of the antifungal agent Fluconazole. Fluconazole is a triazole antifungal agent that is effective against most Candida strains. Synonyms: Fluconazole β-D-Glucuronide; 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-(1H-1,2,4-triazol-1-ylmethyl)ethyl β-D-Glucopyranosiduronic Acid; Fluconazole Glucuronide. Grades: > 95%. CAS No. 136134-23-1. Molecular formula: C20H22F2N6O6. Mole weight: 480.43. | |
| Flucytosine Glucuronide | Flucytosine Glucuronide is a metabolite of the antifungal/antimicrobial agent, 5-Fluorocytosine. Synonyms: 5-Fluoro Cytosine O-β-D-Glucuronide; 4-Amino-5-fluoro-2-pyrimidinyl β-D-Glucopyranosiduronic Acid. Grades: > 95%. CAS No. 150494-26-1. Molecular formula: C10H12FN3O7. Mole weight: 305.22. | |
| FLUNIXIN | Flunixin is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a veterinary medicine. Uses: A nonsteroidal anti-inflammatory drug (nsaid) commonly used as a veterinary medicine. Synonyms: Flunixine; Flunixino; Flunixinum; 2-{[2-methyl-3- (trifluoromethyl) phenyl]amino}nicotinic acid; Sch 14714; Sch14714; Sch-14714. CAS No. 38677-85-9. Molecular formula: C14H11F3N2O2. Mole weight: 296.25. | |
| Fluorapacin | Fluorapacin, also known as bis(4-fluorobenzyl)trisulfide (BFBTS), is a synthetic molecule derived from a bioactive natural product, dibenzyltrisulfide, found in a subtropical shrub, Petiveria allieacea. BFBTS has potent anticancer activities to a broad spectrum of tumor cell lines. Synonyms: Bis[(4-fluorophenyl)methyl] trisulfide; 1,3-bis(4-fluorobenzyl)trisulfane. CAS No. 869811-23-4. Molecular formula: C14H12F2S3. Mole weight: 314.44. | |
| Fluoroclebopride | Fluoroclebopride is useful chemical for PET image study. [18F]fluoroclebopride had been used for PET imaging of dopamine D2 receptors in monkeys. Synonyms: 4-amino-5-chloro-n-(1-(4-fluorobenzyl)-4-piperidinyl)-2-methoxybenzamide. Grades: 98%. CAS No. 154540-49-5. Molecular formula: C20H23ClFN3O2. Mole weight: 391.87. | |
| Fluorogestone acetate | Fluorogestone Acetate (also known as Flurogestone Acetate, Flugestone Acetate, Fluorogesterone Acetate) was first synthesised by G. D. Searle and Company in 1959. The chemical, which has progestogen activity, was identified as SC-9880. Fluorogestone acetate showed a high potency with short duration of activity and performed physiologically similar to progesterone. FGA was approximately 20 - 25 times more potent than progesterone. Flurogestone acetate was shown to be readily absorbed from impregnated sponges. A 30mg impregnated sponge was effective in blocking ovulation and oestrus, once the sponge was removed impregnated ewes showed visible oestrus, and if inseminated 2 to 4 days after sponge removal showed high conception rates. Synonyms: Flugestone 17-acetate; Flugestone Acetate; 9-Fluoro-11beta,17-dihydroxypregn-4-ene-3,20-dione 17-acetate; NSC 65411; (11beta)17-(Acetyloxy)-9-fluoro-11-hydroxypregn-4-ene-3,20-dione. Grades: 98%. CAS No. 2529-45-5. Molecular formula: C23H31FO5. Mole weight: 406.49. | |
| Fluoxetine D-glucuronide (mixture of isomers) | Synonyms: Fluoxetine glucuronide; 96735-71-6; Fluoxetine N-Beta-D-Glucuronide; CHEBI:173252; DTXSID801116547; (2S, 3S, 4S, 5R, 6R) -3, 4, 5-trihydroxy-6-[methyl-[3-phenyl-3-[4- (triluoromethyl) phenoxy]propyl]amino]oxane-2-carboxylic acid; 1-Deoxy-1-[methyl[3-phenyl-3-[4- (trifluoromethyl) phenoxy]propyl]amino]-beta-D-glucopyranuronic acid. CAS No. 96735-71-6. Molecular formula: C23H26F3NO7. Mole weight: 485.4. | |
| follitropin delta | Follitropin delta is a human recombinant follicle stimulating hormone (human rFSH). It is commonly used for the treatment of ovarian stimulation for the development of multiple follicles in women undergoing assisted reproductive technologies (ART) such as an in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) cycle. Uses: The treatment of ovarian stimulation. Synonyms: Rekovelle. | |
| Foralumab | Foralumab is a human anti-CD3 monoclonal antibody for the treatment of secondary progressive multiple sclerosis. Synonyms: NI-0401; TZLS-401. CAS No. 946415-64-1. | |
| Formononetin-b-D-glucuronide sodium salt | Formononetin-b-D-glucuronide sodium salt is a bioactive derivative originating from formononetin is an isoflavone occurring naturally in numerous plant species. It is used in the research of osteoporosand estrogen-related disorders. Synonyms: 3-(4-Methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl b-D-glucuronic acid; 7-Hydroxy-4-methoxyisoflavone-7-O-b-D-glucuronide; Formononetin-7-O-Glucuronide; Biochanin B-7-O-b-D-glucuronide. CAS No. 18524-03-3. Molecular formula: C22H19O10Na. Mole weight: 466.37. | |
| Forosamine | Forosamine is an indispensable compound crucial in the R&D of antifungal and antibacterial drugs, used for studying an array of drug-resistant fungal infections including Candida and Aspergillus, while also combatting bacterial infections instigated by Staphylococcus aureus and Streptococcus pneumoniae. Synonyms: 4-Dimethylamino-2,3,4,6-tetradeoxy-D-erythro-hexose; 2,3,4,6-tetradeoxy-4-dimethylamino-D-erythro-hexosee; Hexanal, 4-(dimethylamino)-5-hydroxy-, (4S,5R)-; Hexanal, 4-(dimethylamino)-5-hydroxy-, [R-(R*,S*)]-. Grades: ≥95%. CAS No. 18423-27-3. Molecular formula: C8H17NO2. Mole weight: 159.23. | |
| Forsythin | Forsythin is purified from the fruits of Forsythia suspensa. Grades: >98%. CAS No. 96420-61-0. | |
| Fosquidone | Fosquidone is a water-soluble pentacyclic pyrolloquinone analogue of mitoquidone with potential antineoplastic activity. Currently, the mechansim of action of fosquidone is unknown. In vitro studies indicate that this agent does not bind to DNA or inhibit topoisomerases. Synonyms: GR 63178K; GR63178A; GR-63178A; NSC 611615; benzyl (14-methyl-8,13-dioxo-5,8,13,14-tetrahydrobenzo[5,6]isoindolo[2,1-b]isoquinolin-9-yl) hydrogen phosphate. CAS No. 114517-02-1. Molecular formula: C28H22NO6P. Mole weight: 499.46. | |
| Fotemustine | Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. Synonyms: Muphoran, S 10036. Grades: >98%. CAS No. 92118-27-9. Molecular formula: C9H19ClN3O5P. Mole weight: 315.691. | |
| FPH1 | FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes. Synonyms: FPH 1; FPH-1; 2-(N-(5-Chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide. Grades: >98%. CAS No. 708219-39-0. Molecular formula: C16H15ClF2N2O3S. Mole weight: 388.82. | |
| FPH2 | FPH2 is a small molecule, which promotes differentiation of iPS-derived hepatocytes. Synonyms: BRD-9424; BRD9424; BRD 9424; FPH2; FPH 2; FPH-2. Grades: >98%. CAS No. 957485-64-2. Molecular formula: C14H16ClN5O2S. Mole weight: 353.83. | |
| FR-167356 | FR-167356, a benzofuran derivative, has been found to be an acuolar ATPase inhibitor and could probablye be useful in studies of some lytic bone diseases. Synonyms: FR-167356; FR167356; FR 167356; UNII-XF02B1HC8R. DSSTox_CID_28148; DSSTox_RID_82712; 2,6-dichloro-N-[3-(2-hydroxypropan-2-yl)-2-methyl-1-benzofuran-7-yl]benzamide. Grades: 98%. CAS No. 174185-16-1. Molecular formula: C19H17Cl2NO3. Mole weight: 378.25. | |
| FR-167653 | FR-167653 is a p38 mitogen-activated protein kinase inhibitor, which suppresses the development of endometriosis in a murine model. FR-167653 meliorates murine bleomycin-induced pulmonary fibrosis. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: FR-167653; FR 167653; FR167653. CAS No. 158876-66-5. Molecular formula: C24H20FN5O6S. Mole weight: 525.51. | |
| Fremanezumab | Fremanezumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP). Fremanezumab has been investigated for the prevention of high-frequency episodic and chronic migraine. Synonyms: TEV-48125. CAS No. 1655501-53-3. | |
| Fresolimumab | Fresolimumab is a human monoclonal antibody targeting transforming growth factor beta (TGF-β). Fresolimumab inhibits the activity of TGF-beta, which may result in the suppression of tumor cell growth, angiogenesis, and migration. Synonyms: GC1008; GC 1008; GC-1008. CAS No. 948564-73-6. | |
| Fructosazine | Fructosazine is a highly innovative biomedical adjunct, emerging as an exalted compound for studying diabetes. It is a potent fructosamine-3-kinase enzyme inhibitor. Synonyms: D-Arabino-1,1-(2,5-pyrazinediyl)di-1,2,3,4-butanetetrol; Tagatosazine. CAS No. 13185-73-4. Molecular formula: C12H20N2O8. Mole weight: 320.30. | |
| Fructose-alanine (mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-alanine; (S)-1-[(1-Carboxyethyl)amino]-1-deoxy-D-fructose; 1-Alanino-1-deoxy-D-fructose; 1-Deoxy-1-L-alanine-D-fructose; N-(1-Deoxy-D-fructosyl)-L-alanine. Grades: 95%. CAS No. 16124-24-6. Molecular formula: C9H17NO7. Mole weight: 251.23. | |
| Fructose-asparagine (Mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N2-(1-Deoxy-D-fructos-1-yl)-L-asparagine; (S)-1-[(3-Amino-1-carboxy-3-oxopropyl)amino]-1-deoxy-D-fructose; 1-[(2-Carbamoyl-1-carboxyethyl)amino]-1-deoxy-fructose; 1-Deoxy-1-L-asparagino-D-fructose; N-(1-Deoxy-D-fructosyl)-L-asparagine. Grades: 95%. CAS No. 34393-27-6. Molecular formula: C10H18N2O8. Mole weight: 294.26. | |
| Fructose-glutamic Acid-D5 | Fructose-glutamic acid-D5 is a labelled analogue of Fructose-glutamic acid, is an Amadori compound (derivatives of aminodeoxysugars) that is formed in food (such as dehydrated fruits tomatoes and carrots) result in the Maillard reactions. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-glutamic Acid-D5; (S)-1-Deoxy-1-[(1,3-dicarboxypropyl)amino]-D-fructose-D5; 1-Deoxy-1-[(L-1,3-dicarboxypropyl)amino]-D-fructose-D5; L-Glutamic Acid D-Fructose Deriv.-D5; 1-Deoxy-1-(L-glutamyl)-D-fructose-D5; N-Fructosylglutamic Acid-D5. Molecular formula: C11H14D5NO9. Mole weight: 314.3. | |
| Fructose-isoleucine (mixture of diastereomers) | Fructose-isoleucine is an Amadori compound (aminodeoxysugars derivatives) that is formed in food, which could induce the Maillard reactions. Synonyms: N-(1-Deoxy-β-D-fructopyranos-1-yl)-L-isoleucine; [S-(R*,R*)]-1-[(1-Carboxy-2-methylbutyl)amino]-1-deoxy-β-D-fructopyranose. CAS No. 87304-79-8. Molecular formula: C12H23NO7. Mole weight: 293.31. | |
| Fructose L-Arginine Adduct | α-Fructose L-Arginine is an analogue of Fructose-leucine, an amadori compound having the potential properties to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: (S)1-[[4-[(Aminoiminomethyl)amino]-1-carboxybutyl]amino]-1-deoxy-D-fructose; D-1-[(1-Carboxy-4-guanidinobutyl)amino]-1-deoxy-fructose. CAS No. 25020-14-8. Molecular formula: C12H24N4O7. Mole weight: 336.34. | |
| Fructose-leucine (mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-leucine; (S)-1-[(1-Carboxy-3-methylbutyl)amino]-1-deoxy-D-fructose; D-1-[(L-1-Carboxy-3-methylbutyl)amino]-1-deoxy-fructose; 1-Deoxy-1-L-leucino-D-fructose; Fructoseleucine. Grades: 98%. CAS No. 34393-18-5. Molecular formula: C12H23NO7. Mole weight: 293.31. | |
| Fructose-phenylalanine (mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-phenylalanine; (S)-1-[(1-Carboxy-2-phenylethyl)amino]-1-deoxy-D-fructose; 1-[(α-Carboxyphenethyl)amino]-1-deoxy-fructose; N-(1'-Carboxy-2'-phenylethyl)amino-1-deoxyfructose. Grades: 98%. CAS No. 31105-03-0. Molecular formula: C15H21NO7. Mole weight: 327.33. | |
| Fructose-proline (mixture of diastereomers) | An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: 1-(1-Deoxy-D-fructos-1-yl)-L-proline; (S)-1-(2-Carboxy-1-pyrrolidinyl)-1-deoxy-D-fructose; 1-Deoxy-1-L-proline-D-fructose; 1-Deoxy-1-L-prolino-D-fructose. Grades: 97%. CAS No. 29118-61-4. Molecular formula: C11H19NO7. Mole weight: 277.27. | |
| Fructose-tryptophan (mixture of diastereomers) | An Amadori compound having the potential properties to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-tryptophan; (S)-1-[[1-Carboxy-2-(1H-indol-3-yl)ethyl]amino]-1-deoxy-D-fructose; D-Fructose-tryptophan; Fructose-L-tryptophan. Grades: 95%. CAS No. 25020-15-9. Molecular formula: C17H22N2O7. Mole weight: 366.37. | |
| Fructose Valine (mixture of diastereomers) | An Amadori compound having the potential properties to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis. Synonyms: N-(1-Deoxy-D-fructos-1-yl)-L-valine; D-1-[(L-1-Carboxy-2-methylpropyl)amino]-1-deoxy-fructose; 1-Deoxy-1-L-valino-D-fructose; 1-L-Valine-1-deoxy-D-fructose; Fructosyl-valine; N-Fructosyl Valine. Grades: 98%. CAS No. 10003-64-2. Molecular formula: C11H21NO7. Mole weight: 279.29. | |
| Fructosyl-lysine | Fructosyl-lysine is an indispensable compound, holding immense value for evaluating glycation. Glycation is a fundamental process intricately linked to multifarious ailments including diabetes, alzheimer's and aging. Synonyms: fructosyl-lysine; Fructosyllysine; fructoselysine; 21291-40-7; Fructose lysine; epsilon-Fructoselysine; epsilon-fructosyl-L-lysine; F2RDS6J0Y0; N(6)-(1-deoxy-D-fructos-1-yl)-L-lysine; L-Lysine, N6-(1-deoxy-D-fructos-1-yl)-; 1-{[(5S)-5-amino-5-carboxypentyl]amino}-1-deoxy-D-fructose; N6-((3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl)-L-lysine; N6-(D-fructosyl)-L-lysine; UNII-F2RDS6J0Y0; SCHEMBL1115953.EPSILON.-FRUCTOSELYSINE; CHEBI:24109; DTXSID301045836; AKOS040741768.EPSILON.-N-DEOXYFRUCTOSYLLYSINE; HY-129380; CS-0105134; 1-DEOXY-1-(.EPSILON.-N-L-LYSINO)-D-FRUCTOSE; Q25101009; N.EPSILON.-(1-DEOXY-D-FRUCTOS-1-YL)-L-LYSINE; (2S)-2-amino-6-[[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl]amino]hexanoic acid. CAS No. 21291-40-7. Molecular formula: C12H24N2O7. Mole weight: 308.33. | |
| FTI-2148 | FTI-2148 is a potent farnesyltransferase inhibitor with potential antitumor activity. Synonyms: FTI 2148; FTI2148; (S)-2-(5-((((1H-Imidazol-5-yl)methyl)amino)methyl)-2'-methyl-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoic acid. Grades: 98%. CAS No. 251577-09-0. Molecular formula: C24H28N4O3S. Mole weight: 452.57. | |
| FTI-2153 | FTI-2153 is a potent farnesyltransferase inhibitor. FTI-2153 inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status. FTI-2153 was reported to block bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells. Synonyms: FTI 2153; FTI2153; (S)-2-[(5-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}-2''-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid methyl ester. CAS No. 344900-92-1. Molecular formula: C25H30N4O3S. Mole weight: 466.6. | |
| FTI-249 | FTI-249 is a Farnesyltransferase inhibitor, which potently inhibited FTase (IC50 = 100-200 nM). Synonyms: FTI 249; FTI249; (S)-2-(4-(((R)-2-amino-3-mercaptopropyl)amino)benzamido)-4-(methylthio)butanoic acid. Grades: 98%. CAS No. 161721-65-9. Molecular formula: C15H23N3O3S2. Mole weight: 357.49. | |
| FTI-276 | FTI-276 is a potent and selective farnesyltransferase inhibitor, which is also a tetrapeptide mimetic of the carboxyl terminus of K-Ras4B. FTI-276 blocked the growth in nude mice of a human lung carcinoma that expresses the two most prevalent genetic alterations in human cancers (K-Ras oncogenic mutation and deletion in the tumor suppressor gene p53). In contrast, FTI-276 did not inhibit tumor growth of a human lung carcinoma that harbors no Ras mutations. Furthermore, FTI-276 inhibited oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the ras but not the raf oncogene. Synonyms: FTI276; FTI 276; (S)-2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoic acid. CAS No. 170006-72-1. Molecular formula: C21H27N3O3S2. Mole weight: 433.59. | |
| Fucose 2-nitrophenylhydrazone | Fucose 2-nitrophenylhydrazone is an indispensable compound exhibiting inhibitory efficacy in studying select cancer types encompassing breast and colon carcinomas. Molecular formula: C12H17N3O6. Mole weight: 299.28. | |
| Fulranumab | Fulranumab is a human monoclonal antibody against nerve growth factor. Inhibition of the NGF pathway may prevent the perception of pain and may induce analgesia. CAS No. 902141-80-4. | |
| Fulvestrant-3-Glucuronide | Fulvestrant-3-Glucuronide is a metabolite of Fulvestrant. Synonyms: (7a, 17b) -17-Hydroxy-7-[9-[ (4, 4, 5, 5, 5-pentafluoropentyl) sulfinyl]nonyl]estra-1, 3, 5 (10) -trien-3-yl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 261506-27-8. Molecular formula: C38H55F5O9S. Mole weight: 782.90. | |
| Furafylline | Furafylline is a xanthine derivative and a selective inhibitor of human cytochrome P450 (CYP)1A2 with an IC50 of 0.07 μM. It was reported to inhibit the oxidation of caffeine. Synonyms: 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-1H-purine-2,6-dione; 3-Furfuryl-1,8-dimethylxanthine; 3-(furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione; 1,8-dimethyl-3-(2'-furfuryl)-1H-purine-2,6-dione; Furafilina; Furafyllinum. Grades: 95%. CAS No. 80288-49-9. Molecular formula: C12H12N4O3. Mole weight: 260.25. | |
| Furalazine | Furalazine is an antibiotic agent with activity against drug-resistant strains of cholera bacteria. It was more effective in reducing the duration of positive stool culture than chloramphenicol. It may be potentially used in the treatment of cholera. Uses: Furalazine is an antibiotic agent with activity against drug-resistant strains of cholera bacteria. it may be potentially used in the treatment of cholera. Synonyms: Furalazinum; Nifuralazinum; Panfuran; 3-Amino-6-(2-(5-nitro-2-furyl)vinyl)-1,2,4-triazine; 1,2,4-Triazin-3-amine, 6-(2-(5-nitro-2-furanyl)ethenyl)- (9CI). Grades: 98%. CAS No. 556-12-7. Molecular formula: C9H7N5O3. Mole weight: 233.18. | |
| Furaneol glucopyranoside | Furaneol glucopyranoside is a remarkable bioactive compound extensively utilized in the biomedical sector, applied to study diabetes and its related complications. This compound exhibits profound efficacy in the regulation of blood sugar levels and the mitigation of oxidative stress. Synonyms: 2,5-Dimethyl-4-hydroxy-3(2H)-furanone 6O-malonyl-beta-D-glucopyranoside; HDMF glucoside. Molecular formula: C12H18O9. Mole weight: 306.27. | |
| Furazlocillin | Fuzlocillin is a semisynthetic acylureidopenicillin with antibacterial activity. It binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thus preventing the cross-linkage of peptidoglycans, which leads to an interruption of the bacterial cell wall and causes bacterial cell lysis. Uses: Fuzlocillin has antibacterial activity. Synonyms: 6α -[[ (R) -[[[3-[[ (E) - (2-Furanyl) methylene]amino]-2-oxoimidazolidin-1-yl]carbonyl]amino] (4-hydroxyphenyl) acetyl]amino]penicillanic acid; BAY-k-4999. Grades: 98%. CAS No. 66327-51-3. Molecular formula: C25H26N6O8S. Mole weight: 570.58. | |
| Furosemide acyl glucuronide | Furosemide acyl glucuronide is a metabolite of Furosemide. Synonyms: (2S,3S,4S,5R)-6-[4-Chloro-2-(2-Furylmethylamino)-5-Sulfamoyl-Benzoyl]Oxy-3,4,5-Trihydroxy-Tetrahydropyran-2-Carboxylic Acid; (2S,3S,4S,5R)-6-[[4-Chloro-2-(2-Furylmethylamino)-5-Sulfamoylphenyl]-Oxomethoxy]-3,4,5-Trihydroxy-2-Tetrahydropyrancarboxylic Acid. Grades: > 95%. CAS No. 72967-59-0. Molecular formula: C18H19ClN2O11S. Mole weight: 506.87. | |
| Fusidic acid acyl glucuronide | Fusidic acid acyl glucuronide is a metabolite originating from fusidic acid, acting as an efficacious antimicrobial compound employed for studying diverse bacterial ailments. It manifestly demonstrates amplified pharmacokinetic attributes encompassing heightened bioavailability and metabolic steadfastness. Synonyms: Fusidic acid b-D-glucopyranuronosyl ester. CAS No. 13013-66-6. Molecular formula: C37H56O12. Mole weight: 692.83. | |
| G3130 | G3130 is a reversible Hsp90 inhibitor with potential anticancer activity. G3130 demonstrated cellular activities (in Her-2 degradation and activation of Hsp70 promoter) consistent with the inhibition of cellular Hsp90 functions. Synonyms: G-3130; G 3130; 4-(4-(1H-imidazol-4-yl)-1H-pyrazol-3-yl)-6-ethylbenzene-1,3-diol. Grades: 98%. CAS No. 848952-37-4. Molecular formula: C14H14N4O2. Mole weight: 270.29. | |
| G-573 | G-573 is an allosteric inhibitor of MEK that is both potent and selective. The IC(50) value for pERK inhibition in HCT116 tumours by G-573 was estimated to be 0.406? μM. The IC(50) values for tumour growth inhibition in HCT116 and H2122 were estimated to be 3.43 and 2.56?μM, respectively. ED(50) estimates in HCT116 and H2122 mouse xenograft models were estimated to be ~4.6 and 1.9?mg/kg/day, respectively. Synonyms: G 573; G573; 2-(3-chlorophenyl)benzimidazole; OTAVA-BB; 1H-Benzimidazole, 2-(3-chlorophenyl)-; Benzimidazole, 2-(m-chlorophenyl)-; 2-(3-Chlorophenyl)-1H-1,3-benzodiazole; 2-(3'-Chlorophenyl)benzimidazole; 2-(m-Chlorophenyl)benzimidazole. Grades: ≥95%. CAS No. 22868-35-5. Molecular formula: C13H9ClN2. Mole weight: 228.68. | |
| GA3-AM | GA3-AM is a Gibberellic acid analog that induces rapid dimerization of GAIs and GID1. GA3-AM is cleaved by cytosolic esterase releasing GA3, which binds GID1- this complex then in turn forms a complex with GAI. Gibberellic acid is a hormone that acts as a plant growth regulator for its physiological and morphological effects at extremely low concentrations. Synonyms: GA3-AM; GA3 AM; GA3AM; (1S,2S,4aR,4bR,7S,9aS,10S,10aR)-1,2,4b,5,6,7,8,9,10,10a-Decahydro-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-4a,1-(epoxymethano)-7,9a-methanobenz[a]azulene-10-acetic acid (acetyloxy)methyl ester; Gibberellic Acid Acetoxymethyl Ester. Grades: ≥90% by HPLC. CAS No. 1373154-68-7. Molecular formula: C22H26O8. Mole weight: 418.44. | |
| GABOB (beta-hydroxy-GABA) | GABOB, also known as γ-Amino-β-hydroxybutyric acid, β-hydroxy-γ-aminobutyric acid, β-hydroxy-GABA, is an anticonvulsant. It is also an endogenous active metabolite and analogue of the neurotransmitter γ-aminobutyric acid (GABA), and for this reason, may function as a neurotransmitter itself. Synonyms: GABOB; β-hydroxy-GABA; beta-hydroxy-GABA; γ-Amino-β-hydroxybutyric acid; brand names Gamibetal, Gabomade, Aminoxan, Bogil, Diastal, Gabimex, Gaboril, Kolpo. Grades: 98%. CAS No. 7013-05-0. Molecular formula: C4H9NO3. Mole weight: 119.12. | |
| Galacto-PUGNAc | Galacto-PUGNAc is a synthetic compound widely employed in the biomedical sector, standing as a renowned potent inhibitor. Its primary application centers around investigating the intricate involvement of O-GlcNAcase (OGA) in diseases encompassing cancer and diabetes. This remarkable chemical compound selectively targets and inhibits the activity of OGA, thereby impeding the elimination of N-acetylglucosamine (GlcNAc) from protein residues. Synonyms: 2-(Acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-D-galactonimidic acid δ-lactone; Gal-PUGNAc. CAS No. 1145878-98-3. Molecular formula: C15H19N3O7. Mole weight: 353.33. | |
| Galactostatin bisulfite | Galactostatin bisulfite, an exceptional biomedical product, emerges as a targeted intervention against the rampant overexpression of galactose in specific ailments. Its distinctive molecular configuration affords it the capacity to selectively impede the enzymatic process accountable for galactose amalgamation, proffering promising avenues for managing galactosemia and other galactose-linked afflictions. Synonyms: Galactonojirimycin bisulfite; 5-Amino-5-deoxy-D-galactopyranose; 6-(Hydroxymethyl)-2,3,4,6-peperidinetetrol hydrogensulfite. CAS No. 1196465-02-7. Molecular formula: C6H13NO7S. Mole weight: 243.24. | |
| Galanin (1-15) (porcine, rat) | Galanin (1-15) (porcine, rat) is a N-terminal galanin fragment. It modulates central cardiovascular effects in contrast to the full length (1-29) peptide. Synonyms: Galanin (1-15); 1-15-Galanin(cattle)(9ci). CAS No. 112747-70-3. Molecular formula: C72H105N19O20. Mole weight: 1556.74. | |
| Galantamine-O-D-glucuronide | Galantamine-O-D-glucuronide is a extensively utilized compound within the biomedical realm, emerging as a formidable metabolite derived from Galantamine. Galantamine-O-D-glucuronide is a tool used for studying notorious Alzheimer's disease, Galantamine-O-D-glucuronide triumphs in its pivotal involvement concerning the intricate realms of drug metabolism and pharmacokinetics, thus impeccably contributing to its paramount effectiveness and unwaveringly safe profile. Molecular formula: C23H29NO9. Mole weight: 463.48. | |
| Galcanezumab | Galcanezumab is a humanized monoclonal antibody that selectively binds to calcitonin gene-related peptide (CGRP). Galcanezumab has the potential for the preventive treatment of chronic migraine. Synonyms: LY 2951742; LY2951742; LY-2951742. CAS No. 1578199-75-3. | |
| Galloflavin Potassium salt | Galloflavin Potassium salt is an inhibitor of human lactate dehydrogenase (LDH) (Ki = 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate) with anticancer activity. Galloflavin inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells. Synonyms: NSC-107022 potassium; NSC 107022 potassium; NSC107022 potassium; 3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt. Grades: ≥95% by HPLC. CAS No. 1780260-20-9. Molecular formula: C12H5O8K. Mole weight: 316.26. | |
| γ-D-Glutamylglycine | γ-D-Glutamylglycine is a broad spectrum glutamate receptor (GluR) antagonist. Synonyms: Glycine, D-γ-glutamyl-; Glutamine, N-(carboxymethyl)-, D-; Glycine, N-D-γ-glutamyl-; (R)-2-Amino-5-(carboxymethylamino)-5-oxopentanoic acid; D-γ-Glutamylglycine; gammaDGG; gamma DGG; gamma-DGG; DGG; D-N-(Carboxymethyl)glutamine; N-D-γ-Glutamylglycine. Grades: ≥99% by HPLC. CAS No. 6729-55-1. Molecular formula: C7H12N2O5. Mole weight: 204.18. | |
| GANT58 | GANT 58 inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Synonyms: NSC 75503; GANT58; GANT-58; GANT 58; NSC-75503; NSC75503. Grades: 0.99. CAS No. 64048-12-0. Molecular formula: C24H16N4S. Mole weight: 392.47564. | |
| Gantenerumab | Gantenerumab is a human monoclonal antibody targeting amyloid-β (Aβ). Gantenerumab was developed for the treatment of early symptomatic and asymptomatic Alzheimer's disease (AD). CAS No. 1043556-46-2. | |
| Garcimangosone D | Garcimangosone D, is a naturally occurring compound that is found in the Diospyros kaki leaves. The cytotoxic effects of this compound was tested against various animal cell lines (human A59 cell line, human HT-29 cell line and human Hep G2 cell line). Synonyms: [2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]phenyl-methanone. CAS No. 356055-68-0. Molecular formula: C19H20O9. Mole weight: 392.36. | |
| Garcinol | Garcinol is an inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 = 5 and 7 μM, respectively), which is isolated from Garcinia indica. It also inhibits the HAT GCN5 in Cryptococcus neoformans. Garcinol promotes expansion of human HSCs ex vivo. It induces apoptosis in some cancer cells thus can be used as a cancer therapy. Synonyms: Camboginol; (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione. Grades: ≥98% by HPLC. CAS No. 78824-30-3. Molecular formula: C38H50O6. Mole weight: 602.8. | |
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