BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Isopropyl 2-acetamido-2-deoxy-b-D-glucopyranoside | Isopropyl 2-acetamido-2-deoxy-b-D-glucopyranoside, known for its essentiality in biomedicine, plays a crucial role in synthesizing glycosylated drugs and exploring glycobiology within the pharmaceutical sector. Its significance extends to the treatment of diverse ailments, encompassing bacterial and viral infections, cancer, and inflammation. This compound's invaluable utility in drug development and research stems from its structural resemblance to natural glycan structures. Synonyms: Isopropyl 2-acetamido-2-deoxy-b-D-glucopyranoside; N-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-propan-2-yloxyoxan-3-yl]acetamide; DTXSID30428814; MFCD08703886; AKOS002687845; E83248; W-203801; Propan-2-yl 2-acetamido-2-deoxy-beta-D-glucopyranoside; ISOPROPYL 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE. CAS No. 78341-33-0. Molecular formula: C11H21NO6. Mole weight: 263.29. |  |
| Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside | Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside, a pivotal compound in the pharmaceutical industry, finds extensive utility in synthesizing glycoproteins and glycolipids, thereby serving diverse biomedical purposes. Its indispensable role extends to targeting bacterial and viral infections, as well as combatting ailments like cancer and neurodegenerative disorders. Synonyms: Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside; 7772-85-2; AKOS002687909; Isopropyl-2-acetamide-3,4,6-tri-O-acetyl-2-deoxy-beta-D-glucopyranoside; W-203786. CAS No. 7772-85-2. Molecular formula: C17H27NO9. Mole weight: 389.4. | |
| Isopropyl 2-amino-2-deoxy-b-D-glucopyranoside HCl | Isopropyl 2-amino-2-deoxy-b-D-glucopyranoside HCl is an indispensable pharmaceutical compound extensively utilized in the biomedical domain, used in the synthesis of diverse drug entities envisage studying bacterial or viral afflictions. | |
| Isopropyl-a-D-thiomannopyranoside | Isopropyl-α-D-thiomannopyranoside is a widely employed synthetic compound in the biomedical industry, exhibiting significant utility as a molecular probe for the inhibition of specific enzymes and subsequent investigation of their functionalities. Synonyms: IPTG (dioxane free); 2-(hydroxymethyl)-6-propan-2-ylsulfanyloxane-3,4,5-triol; Isopropyl-a-D-thiomannopyranoside; beta-D-Galactopyranoside, 1-methylethyl 1-thio-; 936550-10-6; Maybridge3_000466; SCHEMBL12291669; SCHEMBL20341170; DTXSID60859354; Propan-2-yl 1-thiohexopyranoside; Isopropyl.beta.- thiogalactoside; 2-(hydroxymethyl)-6-(propan-2-ylsulfanyl)oxane-3,4,5-triol; HMS1432F04; HMS3604O21; ZINC00134320; IDI1_011853; FT-0627483; FT-0772631; EN300-114826. CAS No. 936550-10-6. Molecular formula: C9H18O5S. Mole weight: 238.30. | |
| Isopropyl-b-D-thioglucopyranoside | Isopropyl-b-D-thioglucopyranoside, the renowned biochemical compound, is widely embraced in the biomedicine industry due to its multipurpose properties. As an esteemed inducer of β-galactosidase, it remarkably amplifies the expression of recombinant proteins. Notably, its profound capability to impede glucose binding to enzymes confers it a pivotal role in unraveling the intricacies of gene expression, protein synthesis, and carbohydrate utilization. Its extensive application within pharmaceutical research manifests in the effective treatment of ailments arising from enzyme deficiencies and protein expression irregularities. Prepare to be captivated by the academic and scientific aura this unparalleled compound possesses. Synonyms: Isopropyl beta-D-thioglucopyranoside; (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol; Isopropyl |A-D-thioglucopyranoside; beta-D-Glucopyranoside, 1-methylethyl 1-thio-; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-propan-2-ylsulfanyloxane-3,4,5-triol; isopropyl-beta-d-thioglucopyranoside; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(propan-2-ylsulfanyl)oxane-3,4,5-triol; Isopropyl 1-thio-beta-D-glucopyranoside; Isopropyl beta-D-thioglucoside; SCHEMBL1032089; CHEBI:177463; CCG-50219; Isopropyl beta -D-thioglucopyranoside; MFCD00069833; HY-W145651; 1-Methylethyl 1-thio-beta-D-glucopyranoside; CS-0226080; SR-01000639614-1; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-propan-2-ylsulanyloxane-3,4,5-triol. CAS No. 19165-11-8. Molecular formula: C9H18O5S. Mole weight: 238.30. | |
| Isopropyl b-D-thioglucuronide sodium salt | Isopropyl b-D-thioglucuronide sodium salt, an esteemed biomedical substance, plays a pivotal role in assessing and quantifying the metabolic prowess of glucuronidases. Its undeniable significance extends to drug investigations and pharmacokinetic inquiries, wherein it unveils paramount insights into the breakdown and elimination of drugs, particularly those undergoing glucuronidation pathways. Synonyms: IPTGlcA.Na; Isopropyl b-D-thioglucuronic acid sodium salt. CAS No. 208589-93-9. Molecular formula: C9H15NaO6S. Mole weight: 274.27. | |
| Isopropylbeta-D-glucopyranoside | Isopropylbeta-D-glucopyranoside, a compound highly esteemed in the biomedical sector, is bestowed with its multitude of utilities. Primarily employed as a chemical reagent, this remarkable entity enables meticulous scrutiny of protein expression and refolding phenomena. Synonyms: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-propan-2-yloxyoxane-3,4,5-triol. Grades: 95%. CAS No. 5391-17-3. Molecular formula: C9H18O6. Mole weight: 222.24. | |
| Isosaccharinic acid | Isosaccharinic acid is a multifaceted and versatile chemical compound that exhibits inhibitory efficacy in studying a multitude of ailments such as diabetes, obesity and neurodegenerative disorders. Synonyms: a-D-Isosaccharinic acid. CAS No. 1518-54-3. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| Isosaccharinic acid-1,4-lactone | Isosaccharinic acid-1,4-lactone, a molecule with significant pharmacological value, exhibits therapeutic efficacy against metabolic disorders. This biological agent detains the catabolism of intricate carbohydrates through the inhibition of specific enzymes, thereby preventing an abrupt escalation in blood glucose levels. Notably, Isosaccharinic acid-1,4-lactone also elicits potent anti-inflammatory activity, signifying its therapeutic potential in diverse inflammatory conditions. Synonyms: Isosaccharino-1,4-lactone; 7397-89-9; Isosaccharinic acid-1,4-lactone; (3S,5S)-3-hydroxy-3,5-bis(hydroxymethyl)oxolan-2-one; 20261-94-3; alpha-D-Isosaccharino-1,4-lactone; alpha-D-Isosaccharin; Isosaccharinicacid-1,4-lactone; SCHEMBL7150499; DTXSID40224708; Beta-D-isosaccharino-1,4-lactone; 3-Deoxy-2-C-(hydroxymethyl)-D-erythro-pentonic acid gamma-lactone; MFCD18252312; 3-deoxy-2-C-hydroxymethyl-D,L-tetrono-1,4-lactone; (3S,5S)-3-Hydroxy-3,5-bis-hydroxymethyl-dihydro-furan-2-one; (3S,5S)-3-hydroxy-3,5-bis(hydroxymethyl)tetrahydrofuran-2-one; D-erythro-Pentonic acid, 3-deoxy-2-C-(hydroxymethyl)-, gamma-lactone. CAS No. 7397-89-9. Molecular formula: C6H10O5. Mole weight: 162.14. | |
| Isoschaftoside | Antinociceptive and anti-inflammatory activities. Uses: Antioxidant; anticancer. Synonyms: 6-C-alpha-L-Arabinosyl-8-C-beta-D-glucosylapigenin; Apigenin 6-C-alpha-L-arabinopyranoside-8-C-beta-D-glucopyranoside; Isoshaftoside; apigenin-6-α-L-arabinosyl-8-β-glucoside. Grades: >98%. CAS No. 52012-29-0. Molecular formula: C26H28O14. Mole weight: 564.49. | |
| Isosorbide 5-Mononitrate | A coronary vasodilator that does not require hepatic biotransformation. Synonyms: Isosorbide mononitrate. Grades: >98%. CAS No. 16051-77-7. Molecular formula: C6H9NO6. Mole weight: 191.14. | |
| Isosorbide 5-Mononitrate 2-β-D-Glucuronide | A metabolite of Isosorbide 5-Mononitrate. Synonyms: 1,4:3,6-Dianhydro-2-O-β-D-glucopyranuronosyl-D-glucitol 5-Nitrate. Grades: > 95%. CAS No. 32871-20-8. Molecular formula: C12H17NO12. Mole weight: 367.26. | |
| Isotretinoin Glucuronide | Isotretinoin Glucuronide is a metabolite of 13-cis-Retinoic acid. Synonyms: 13-cis-Retinoic acid b-D-glucopyranuronic acid. CAS No. 78147-42-9. Molecular formula: C26H36O8. Mole weight: 476.56. | |
| ITD-1 | ITD-1 is an effective and highly selective TGF-β signaling inhibitor. It promotes differentiation of cardiomyocytes from embryonic stem cells (ESCs) via TGF-β type II receptor degradation. Uses: Itd-1 is an effective and highly selective tgf-β signaling inhibitor so that it might have potential application prospectin in immunity therapy. Synonyms: ITD 1; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate. Grades: >98%. CAS No. 1099644-42-4. Molecular formula: C27H29NO3. Mole weight: 415.52. | |
| IU1 | IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. Synonyms: IU 1; IU-1; 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one. Grades: >98%. CAS No. 314245-33-5. Molecular formula: C18H21FN2O. Mole weight: 300.37. | |
| Ivuxolimab | Ivuxolimab is a humanized agonistic IgG2 monoclonal antibody. Ivuxolimab selectively binds to OX40, resulting in proliferation of memory and effector T lymphocytes. Synonyms: PF-04518600; PF 04518600; PF04518600. CAS No. 2128729-41-7. | |
| IWP 4 | IWP 4 is a novel and potent inhibitor of Wnt/β-catenin signaling with IC50 value of 25 nM. It blocks palmitylation, subsquent secretion and activity of Wnt. It induces the differentiation of human pluripotent stem cells into cardiomyocytes. It has minimal effect on Notch and Hedgehog signaling pathways. Synonyms: IWP4; IWP 4; IWP-4; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide; 2-(3,4,6,7-Tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide. Grades: ≥98% by HPLC. CAS No. 686772-17-8. Molecular formula: C23H20N4O3S3. Mole weight: 496.62. | |
| IWP-L6 | IWP-L6 is a potent Porcupine inhibitor with EC50 value of 0.5 nM. It also inhibits Wnt/β-catenin pathway. Synonyms: IWP L6; Porcn Inhibitor III; 2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide. Grades: >98%. CAS No. 1427782-89-5. Molecular formula: C25H20N4O2S2. Mole weight: 472.58. | |
| ixekizumab | Ixekizumab is a humanized monoclonal antibody that inhibits interleukin 17A (IL-17A). It was approved by FDA for the treatment of moderate to severe plaque psoriasis in adult patients. Uses: The treatment of plaque psoriasis. Synonyms: LY2439821; Taltz. Grades: ≥98%. CAS No. 1143503-69-8. Molecular formula: C6492H10012N1728O2028S46. Mole weight: 146200. | |
| Ixoroside | Ixoroside is an intriguing biomedical compound used for studying malignant tumors, spanning from the intricate lung to the formidable breast and pancreatic neoplasms. Synonyms: (1S,4aS,7S,7aS)-1-(b-D-Glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-7-hydroxy-7-methylcyclopenta[c]pyran-4-carboxaldehyde. CAS No. 58514-30-0. Molecular formula: C16H24O9. Mole weight: 360.36. | |
| JH295 | JH295 is an irreversible, cysteine-targeted inhibitor of the human centrosomal kinase, Nek2. JH295 irreversibly inhibited cellular Nek2 without affecting the mitotic kinases, Cdk1, Aurora B, or Plk1. Moreover, JH295 did not perturb bipolar spindle assembly or the spindle assembly checkpoint. To our knowledge, JH295 is the first small molecule shown to inactivate Nek2 kinase activity in cells. Synonyms: JH 295; JH-295; 3-[(2-Ethyl-4-methyl-1H-imidazole)-5-ylmethylene]-5-[(1-oxo-2-propynyl)amino]-1H-indole-2(3H)-one. CAS No. 1311143-71-1. Molecular formula: C18H16N4O2. Mole weight: 320.35. | |
| JHU-16907 | Cas No. 942063-86-7. | |
| JHU-292 | JHU-292 is the prodrug of 6-diazo-5-oxo-L-norleucine (DON), a glutaminase antagonist with therapeutic effect on hematological malignancies. Compared to DON, JH-292 exhibits excellent stability in human plasma and reduced gastrointestinal side effects. It would be metabolized to DON in tumor cells with the tumor cell/plasma DON ratio enhanced 15-fold. Uses: The treatment of hematological malignancies. Synonyms: JHU-292; JHU292. | |
| JHW 007 hydrochloride | The hydrochloride salt form of JHW 007, which is a dopamine uptake inhibitor and could also restrain the effects of cocaine in a dose-dependent manner. Synonyms: JHW 007 hydrochloride; JHW007 hydrochloride; JHW-007 hydrochloride; (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride. Grades: ≥99% by HPLC. CAS No. 202645-74-7. Molecular formula: C24H29F2NO.HCl. Mole weight: 421.95. | |
| JMV3002 | JMV3002 is an endogenous ligand for the growth hormone secretagogue receptor (GHSR). It decreased food intake in fasted lean mice in a dose-dependent manner with ED50 value of 2.05 mg/kg, suggesting its potential use in diet-induced obesity (DIO) treatment. Synonyms: N-[1-[4-[(2,4-dimethoxyphenyl)methyl]-5-(2-phenylethyl)-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]pyridine-2-carboxamide. Grades: ≥98%. CAS No. 925239-03-8. Molecular formula: C35H34N6O3. Mole weight: 586.7. | |
| JNJ-1661010 | JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. Synonyms: Takeda-25; N1-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; JNJ 1661010; JNJ1661010; N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide. Grades: ≥98%. CAS No. 681136-29-8. Molecular formula: C19H19N5OS. Mole weight: 365.45. | |
| JNJ-28312141 | JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events. Synonyms: JNJ28312141; JNJ 28312141; 4-cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carboxamide. CAS No. 885692-52-4. Molecular formula: C26H32N6O2. Mole weight: 460.58. | |
| JNJ-54717793 | JNJ-54717793 is a selective antagonist with a preference for Ox1R over Ox2R. Ox1R and Ox2R were indicated to play important roles in the control of sleep-wake, the regulation of food intake, addiction, reward, mood, panic, anxiety and stress. JNJ-54717793 disrupted REM time sleep in Ox2R knockout mice model, and attenuated panic in a CO2-induced model. Uses: Disrupt rem time sleep, attenuate panic. Synonyms: JNJ 54717793; JNJ54717793. CAS No. 1628843-99-1. Molecular formula: C22H18F4N6O. Mole weight: 458.41. | |
| JNJ-64413739 | JNJ-64413739 is a potential P2X7 receptor positron emission tomography (PET) tracer, which is potent and selective of human and mice P2X7 receptor. Uses: Potential p2x7 receptor positron emission tomography (pet) tracer. Synonyms: JNJ 64413739; JNJ64413739. Molecular formula: C17H13F4N7O. Mole weight: 407.3. | |
| K02288 | K02288 is a highly selective 2-aminopyridine based inhibitor with in vitro activity against ALK2 at low nanomolar concentrations similar to the current lead compound LDN-193189. K02288 specifically inhibits the BMP-induced Smad pathway without affecting TGF-b signaling and induced dorsalization of zebrafish embryos. Synonyms: K-02288; 3-(6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol. Grades: >98%. CAS No. 1431985-92-0. Molecular formula: C20H20N2O4. Mole weight: 352.38. | |
| K811 | K811 is a specific inhibitor of ASK1, which can prolong the survival time of the mouse model of amyotrophic lateral sclerosis. Synonyms: AC-31496. Grades: ≥98% by HPLC. CAS No. 1355228-38-4. Molecular formula: C29H26N4O5. Mole weight: 510.5. | |
| K812 | K812 is a specific inhibitor of ASK1 that can prolong the survival time of a mouse model of amyotrophic lateral sclerosis. Synonyms: AC-31495. Grades: ≥98% by HPLC. CAS No. 1355228-39-5. Molecular formula: C30H27N3O5. Mole weight: 509.6. | |
| KaempferoL-4-glucoside | Cas No. 52222-74-9. | |
| Kahalalide F | Kahalalide F is one of a family of novel peptides isolated from the Hawaiian mollusk, Elysia rufescens. It is currently in Phase II trials for hepatocarcinoma. Kahalalide F (KF) is a novel antitumor drug of marine origin under clinical investigation. KF showed a potent cytotoxic activity against a panel of human prostate and breast cancer cell lines, with IC50 ranging from 0.07 μm (PC3) to 0.28 μm (DU145, LNCaP, SKBR-3, BT474, MCF7). Importantly, nontumor human cells (MCF10A, HUVEC, HMEC-1, IMR90) were 5-40 times less sensitive to the drug (IC50 = 1.6-3.1 μm). Synonyms: Kahalalide F; PM-92102; PM 92102; PM92102. CAS No. 149204-42-2. Molecular formula: C75H124N14O16. Mole weight: 1477.90. | |
| Kanamycin A Related Compound 2 | An impurity of Tobramycin. Synonyms: Deoxystreptamine-kanosaminide; 6-O-(3-Amino-3-deoxy-α-D-glucopyranosyl)-2-deoxy-D-streptamine; 4-O-(3-Amino-3-deoxy-α-D-glucopyranosyl)-2-deoxy-L-Streptamine. Grades: > 95%. CAS No. 20744-51-8. Molecular formula: C12H25N3O7. Mole weight: 323.35. | |
| Karenitecin | Karenitecin, also known as Cositecan, is a synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Karenitecin stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, karenitecin exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins. Synonyms: Cositecan; BNP 1350; (4S)-4-Ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 7-[2-(Trimethylsilyl)ethyl]camptothecin; DB 172; MCC 12824; (S)-4-ethyl-4-hydroxy-11-(2-(trimethylsilyl)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-, (4S)-. Grades: ≥98%. CAS No. 203923-89-1. Molecular formula: C25H28N2O4Si. Mole weight: 448.59. | |
| KBR-16 | KBR-16 is a novel nuclear receptor retinoic acid receptor-related orphan receptor-gamma (RORgamma) inhibitor derived from ursolic acid. It is used for the treatment of inflammation with excellent oral bioavailability and favorable pharmacokinetic profile. Uses: The treatment of inflammation. Synonyms: KBR 16; KBR16. | |
| KCN1 | KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF reporter gene activity in several glioma cell lines at the nanomolar level. KCN1 also downregulated transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE)-dependent manner. KCN1 potently inhibited the growth of subcutaneous malignant glioma tumor xenografts with minimal adverse effects on the host. Mechanistically, KCN1 did not downregulate the levels of HIF-1α or other components of the HIF transcriptional complex; rather, it antagonized hypoxia-inducible transcription by disrupting the interaction of HIF-1α with transcriptional coactivators p300/CBP.CONCLUSIONS: The new HIF pathway inhibitor KCN1 has antitumor activity in mouse models, supporting its further translation for the treatment of human tumors displaying hypoxia or HIF overexpression. Synonyms: KCN-1; 3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide. CAS No. 927823-01-6. Molecular formula: C26H27NO5S. Mole weight: 465.561. | |
| KDU-731 | KDU-731 is a selective inhibitor of Cryptosporidium lipid kinase PI(4)K over human PI(4)K. It exhibits potential cardiotoxicity, mutagenicity, clastogenicity or phototoxicity. KDU-731 is a new treatment for pediatric diarrhea caused by the parasite Cryptosporidium. Uses: Pediatric diarrhea caused by the parasite cryptosporidium. Synonyms: KDU 731; KDU731. CAS No. 1610610-48-4. Molecular formula: C22H16N6O2. Mole weight: 396.40. | |
| Keto-D-fructose phthalazin-1-ylhydrazone | Keto-D-fructose phthalazin-1-ylhydrazone is a pharmacological compound prominently utilized with domain, exhibiting inhibitory efficacy in research of afflictions, primarily encompassing metabolic aberrations and inflammatory disturbances. CAS No. 1082040-10-5. Molecular formula: C14H18N4O5. Mole weight: 322.32. | |
| Ketorolaco | Ketorolaco is a potent, short acting nonsteroidal antiinflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It is a pyrrolizine carboxylic acid derivative structurally related to indomethacin. It is used as an analgesic. It acts by inhibiting the bodily synthesis of prostaglandins. It is also used to treat eye pain and to relieve the itchiness and burning of seasonal allergies. It was developed in 1989 by Syntex Corp. Uses: Ketorolaco is used as an analgesic. it is also used to treat eye pain and to relieve the itchiness and burning of seasonal allergies. Synonyms: ketorolac; Macril; (+-)-Ketorolac; 1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-; Toradol. Grades: 98%. CAS No. 66635-83-4. Molecular formula: C15H13NO3. Mole weight: 255.27. | |
| Ketorolac Tromethamine | Ketorolac Tromethamine is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. Synonyms: 5-benzoyl-2,?3-dihydro-1H-pyrrolizine-1-carboxylic acid,compd. with 2-amino-2-(hydroxymethyl)?-1,?3-propanediol (1:1). CAS No. 74103-07-4. Molecular formula: C19H24N2O6. Mole weight: 376.4. | |
| Kevetrin | Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. Synonyms: 4-Isothioureidobutyronitrile; NSC-525990; Carbamimidothioic acid, 3-cyanopropyl ester; thioureido butyronitrile. CAS No. 500863-50-3. Molecular formula: C5H9N3S. Mole weight: 143.21. | |
| KH 7 | KH 7 is a novel and selective inhibitor of soluble adenylyl cyclase (Sac) with IC50 value of 3 - 10 μM in vivo, which is an essential component of cAMP-signaling and is ubiquitously expressed. It blocks cAMP synthesis and shows an antiapoptotic effect at concentrations of 1 - 100 μM. Synonyms: KH7; KH 7; KH-7; (E)-2-(1H-Benzo[d]imidazol-2-ylthio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide; 2-(1H-Benzoimidazol-2-ylsulfanyl)-propionic acid (5-bromo-2-hydroxy-benzylidene)-hydrazide; (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide. Grades: ≥99% by HPLC. CAS No. 330676-02-3. Molecular formula: C17H15BrN4O2S. Mole weight: 419.30. | |
| KHS 101 hydrochloride | KHS 101 hydrochloride is the hydrochloride salt of KHS 101, which is an inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It induces acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo and induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3. It suppresses astrocyte formation. It is a useful intermediate. Synonyms: KHS 101 hydrochloride; KHS-101 hydrochloride; KHS101 hydrochloride; N4-(2-Methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-2,4-pyrimidinediamine hydrochloride; N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 1784282-12-7. Molecular formula: C18H22ClN5S. Mole weight: 375.92. | |
| Ki16198 | Ki16198, the methyl ester of Ki16425, is a potent and orally active LPA receptor antagonist with Kis of 0.34 and 0.93 μM against inositol phosphate production induced by LPA1 and LPA3, respectively. It is effective for pancreatic cancer tumorigenesis and metastasis in vivo. Synonyms: 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonylamino)-3-methyl-5-isoxazolyl)benzylsulfanyl)propanoic acid methyl ester; Propanoic acid, 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-, methyl ester; KI-16198; KI 16198; Methyl 3-((4-(4-(((1-(2-chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)benzyl)thio)propanoate. Grades: >98%. CAS No. 355025-13-7. Molecular formula: C24H25ClN2O5S. Mole weight: 488.98. | |
| Ki23057 | Ki23057 is a a FGFR2 inhibitor, which enhances the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs. Ki23057 might be therapeutically promising for treating drug-resistant gastric cancer cells, especially when used in combination with SN38, PTX, or VP16. The apoptosis process might be the main mechanism underlying the synergistic effect of these combinations. The ERCC1 and p53 genes may play an integral role in the synergism between Ki23057 and chemotherapeutic agents in drug-resistant cell lines. Synonyms: Ki-23057; Ki 23057; 2-((2-((4-(4-((4-(1,1-Dimethylethyl)phenyl)amino)phenoxy)-6-methoxy-7-quinolinyl)oxy)ethyl)amino)ethanol. Grades: 98%. CAS No. 516523-31-2. Molecular formula: C30H35N3O4. Mole weight: 501.63. | |
| KI-328 | KI-328 is a novel KIT inhibitor. KI-328 shows selective potency against KIT kinase for the in vitro kinase assay, and inhibits the growth of wild-type (Wt)- and mutant-KIT-expressing cells, while it has little potency against D816V-KIT. Synonyms: KI 328; KI328. Grades: 98%. CAS No. 930089-25-1. Molecular formula: C25H25N7O3. Mole weight: 471.51. | |
| Kifunensine diacetonide | Kifunensine diacetonide, an indispensable biomedicine tool revered for its potency, takes center stage in the realm of therapeutic interventions for glycoprotein-based diseases. Its remarkable prowess lies in its profound inhibition of α-mannosidase I, thereby triggering the unprecedented accumulation of high-mannose glycoproteins. This profound offering stands as a gateway to unraveling novel revelations surrounding afflictions including cancer, viral infections, and genetic disorders intimately entwined with the intricate world of protein glycosylation. Synonyms: (3aS,3bR,7aR,11aS,11bR)-Hexahydro-2,2,5,5-tetramethyl-7H-[1,3]dioxino[4,5-e]-1,3-dioxolo[4,5-c]imidazo[1,2-a]pyridine-9,10-dione. CAS No. 134234-43-8. Molecular formula: C14H20N2O6. Mole weight: 312.32. | |
| KJ Pyr 9 | KJ Pyr 9 is a cell-permeable inhibitor of c-Myc (Kd = 6.5 nM) that disrupts Myc-Max interaction. Uses: Disrupts myc-max interaction. Synonyms: KJ-Pyr-9; KJPyr-9; KJ Pyr-9; KJ-Pyr9; KJPyr9; KJ Pyr9; 4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide. Grades: ≥98%. CAS No. 581073-80-5. Molecular formula: C22H15N3O4. Mole weight: 385.4. | |
| KL001 | KL001 is a small molecule that specifically interacts with cryptochrome (CRY), blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Uses: Cryptochrome protein (cry) stabilizer. Synonyms: KL 001; KL-001; N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide. Grades: ≥98%. CAS No. 309928-48-1. Molecular formula: C21H22N2O4S. Mole weight: 398.48. | |
| KN-93 Phosphate | KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. Synonyms: (E)-N- (2- ( ( (3- (4-chlorophenyl)allyl) (methyl)amino)methyl)phenyl)-N- (2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate; KN93; KN 93; KN-93; KN-93 phosphate. Grades: >98%. CAS No. 1188890-41-6. Molecular formula: C26H32ClN2O8PS. Mole weight: 599.03. | |
| Ko 143 | Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines. It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice. Synonyms: Ko-143; Ko-143; Ko-143. Grades: >98%. CAS No. 461054-93-3. Molecular formula: C26H35N3O5. Mole weight: 469.57. | |
| KOS-1584 | KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump. Synonyms: KOS 1584; KOS1584; 9,10-didehydroepothilone D; R1645. CAS No. 1032119-44-0. Molecular formula: C27H39NO5S. Mole weight: 489.67. | |
| KP1019 | KP1019, also known as FFC14A, is just the second ruthenium-based anticancer agent after NAMI-A which was developed to the stage of clinical trials. Important steps in the mode of action of KP1019 are thought to be the binding to the serum protein transferrin and the transport into the cell via the transferrin pathway. Additionally, the selective activation by reduction in the tumor might contribute to the low side effects observed in in vivo studies. Apoptosis is induced at non-toxic levels via the mitochondrial pathway. These features distinguish it from the established platinum anticancer drugs and suggest that different types of cancer might be treatable with this drug. Indeed, promising activity against certain types of tumors, which are not successfully treatable with cisplatin, and only a very low incidence of acquired resistance has been observed in in vitro and in vivo studies. Recently, a clinical phase I trial was finished in which none of the treated patients experienced serious side effects, while disease stabilization in five of six evaluable patients was achieved. Synonyms: KP1019; KP 1019; KP-1019; FFC14A; indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)]. CAS No. 124875-20-3. Molecular formula: C21H19Cl4N6Ru. Mole weight: 598.30. | |
| KP372-1 | KP372-1 is a synthetic small molecule AKT inhibitor. KP372-1 is consisted of two isomers: KP372-1A and KP372-1B. KP372-1 showed activities to block signalling downstream of Akt in thyroid tumour cells, leading to inhibition of cell proliferation and increased apoptosis. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in gliobastoma. Synonyms: KP 372-1; indeno[2,3-e]1,2,3,4-tetraazolo[1,5-b]1,2,4-triazin-10-one; 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one. CAS No. 329710-24-9. Molecular formula: C10H4N6O. Mole weight: 224.18. | |
| KR30031 | KR30031 is a novel P-glycoprotein inhibitor with potential anticancer activity. KR30031 is a verapamil analog with fewer cardiovascular effects. The ability of KR-30031 to reduce this efflux transport is equal to that of verapamil, a well-known P-glycoprotein inhibitor. The bioavailability of paclitaxel could be enhanced by coadministration of a P-glycoprotein inhibitor, KR-30031. Synonyms: KR-30031; KR 30031; 1- (3- ( (3, 4-dimethoxyphenethyl) (methyl)amino)propyl)-4, 5-dimethoxy-2, 3-dihydro-1H-indene-1-carbonitrile. Grades: 98%. CAS No. 205535-74-6. Molecular formula: C26H34N2O4. Mole weight: 438.56. | |
| K-Ras(G12C) inhibitor 9 | K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). Synonyms: K-RAS inhibitor 9; N-(1-{2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl}piperidin-4-yl)ethene-1-sulfonamide. Grades: >98%. CAS No. 1469337-91-4. Molecular formula: C16H21ClIN3O4S. Mole weight: 513.78. | |
| KRC-108 | KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumor growth in human HT29 colorectal cancer and NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice. This molecule should serve as a useful lead for inhibitors targeting kinases and may lead to new therapeutics for the treatment of cancer. Synonyms: KRC 108; KRC108; 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine. CAS No. 1146944-35-5. Molecular formula: C20H20N6O. Mole weight: 360.41. | |
| KRIBB3 | KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27. Synonyms: KRIBB-3; KRIBB 3; (6Z)-4-ethyl-3-methoxy-6-[4-(4-methoxyphenyl)-2H-1,2-oxazol-5-ylidene]cyclohexa-2,4-dien-1-one. Grades: 98%. CAS No. 129414-88-6. Molecular formula: C19H19NO4. Mole weight: 325.36. | |
| KRN383 | KRN383 is a novel Flt3 inhibitor with potential anticancer activity. KRN383 inhibited the autophosphorylation of Flt3 bearing internal tandem duplications (ITDs) and the Asp835Tyr (D835Y) point mutation with half-maximal inhibitory concentration (IC(50)) values of < or =5.9 and 43 nM, respectively. KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC(50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prolonged the survival of SCID mice carrying ITD-positive AML cells. The effectiveness of a single oral dose of KRN383 suggests that it has the potential to be used in a wide variety of clinical regimens, including multicycle and combination therapies. Synonyms: KRN 383; KRN-383. CAS No. 919767-02-5. Molecular formula: C17H17N3O4. Mole weight: 327.34. | |
| KRN5500 | KRN5500 is a semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus. KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions. This agent also induces cell differentiation and caspase-dependent apoptosis. Synonyms: KRN-5500; KRN 5500; SPK-241; SPK241; SPK 241; NSC-650426; 4-Deoxy-N- (7H-purin-6-yl) -4- ( ( (2, 4-tetradecadienoylamino) acetyl) amino) heptopyranosylamine. CAS No. 151276-95-8. Molecular formula: C28H43N7O7. Mole weight: 589.69. | |
| KRN7000 | KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. It protects against LPS-induced shock and displays potent antitumor activity in various in vivo models. Synonyms: a-Gal-Cer N-[(1S,2S,3R)-1-[(a-D-Galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]hexacosanamide KRN7000. Grades: >99%. CAS No. 158021-47-7. Molecular formula: C50H99NO9. Mole weight: 858.32. | |
| KRP-203 | KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and migration, as well as angiogenesis and immune responses. Activation of sphingosine kinase by a variety of agonists increases intracellular S1P, which in turn can function intracellularly as a second messenger or be secreted out of the cell and act extracellularly by signaling through S1P (S1P1-5) receptors. The phosphorylated form of KRP 203 demonstrates a high affinity for the S1P1 receptor with an ED50 value in the nM range and an ED50 value >1 μM for the S1P3 receptor. Synonyms: Mocravimod hydrochloride; 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride; 1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3- (phenylmethoxy) phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1). Grades: ≥98%. CAS No. 509088-69-1. Molecular formula: C24H27Cl2NO3S. Mole weight: 480.45. | |
| KRX-0402 | KRX-0402 (O6-benzyl guanine or O6-BG) is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin's lymphoma. Recent research has shown that KRX-0402 can also potentiate the activity of other alkylating agents, such as cyclophosphamide, ifosphamide, cisplatinum and carboplatinum. These drugs are some of the most widely used chemotherapy drugs and are commonly used to treat breast cancer, non-small cell lung cancer and ovarian cancer. Accordingly, It is believed that KRX-0402 may have an important role in making cells more susceptible to the damaging effects of alkylating agents, and that KRX-0402 may have utility in the treatment of multiple forms of cancer. KRX-0402 is administered intravenously. To date, approximately 400 patients have received KRX-0402 in multiple clinical studies. Dose limiting toxicity for KRX-0402 in combination with chemotherapy was bone marrow suppression. KRX-0402 alone has no identified dose limiting toxicity. Two company-sponsored, Phase II clinical trials for KRX-0402 are ongoing. Uses: Enzyme inhibitors. Synonyms: KRX 0402; KRX0402; 6-O-Benzylguanine; 6-(Benzyloxy)-7H-purin-2-amine; O(6)-Benzylguanine; 2-Amino-6-(benzyloxy)purine; NSC-637037; O6-BG. CAS No. 1000874-21-4. Molecular formula: C12H11N5O. Mole weight: 241.254. | |
| KS176 | KS176 is a breast cancer resistance protein inhibitor and also exhibits some extent of inhibition of ATP-binding cassette sub-family G member 2. IC50: 1.39 μM. Uses: Ks176 is a breast cancer resistance protein inhibitor and also exhibits some extent of inhibition of atp-binding cassette sub-family g member 2. Synonyms: KS-176; KS176; KS 176. ZINC86032128; AKOS024458013; CS-5435; HY-19753; CS 5435; HY 19753; CS5435; HY19753. Grades: 98%. CAS No. 1253452-78-6. Molecular formula: C22H19N3O5. Mole weight: 405.40. | |
| KU-0058684 | KU-0058684 is a potent PARP and DNA-PK inhibitors. Synonyms: KU0058684; KU 0058684; KU58684; KU 58684; KU-58684; 1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)pyrrolidine-2,5-dione. Grades: 98%. CAS No. 623578-11-0. Molecular formula: C19H14FN3O3. Mole weight: 351.34. | |
| KU-0060648 | KU-0060648 is a dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3Kα (IC50=4 nM), PI3Kβ (IC50=0.5 nM), PI3Kδ (IC50=0.1 nM) less inhibition of PI3Kγ with IC50 of 0.59 μM. Synonyms: KU0060648; KU 0060648; N-[4-(2-Morpholino-4-oxo-4H-1-benzopyran-8-yl)dibenzothiophene-1-yl]-4-ethylpiperazine-1-acetamide. Grades: >98%. CAS No. 881375-00-4. Molecular formula: C33H34N4O4S. Mole weight: 582.71. | |
| KU-2285 | KU-2285 is a potent hypoxic cell radiosensitizer. At less than 100 mg/kg, KU-2285 sensitized SCCVII tumors more than MISO and SR-2508 by fractionated irradiation. KU-2285 entered clinical trials in late 1990s. Synonyms: KU2285; KU 2285; NSC 635446; alpha,alpha-Difluoro-N-(2-hydroxyethyl)-2-nitro-1H-imidazole-1-propionamide. CAS No. 121077-11-0. Molecular formula: C8H10F2N4O4. Mole weight: 264.19. | |
| KU-55933 | KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. Research results suggest that KU-55933 may be a novel chemotherapeutic agent targeting cancer resistant to traditional chemotherapy or immunotherapy due to aberrant activation of Akt. Furthermore, KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone. Synonyms: KU 55933; KU-55933; KU55933. CAS No. 587871-26-9. Molecular formula: C21H17NO3S2. Mole weight: 395.49. | |
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