BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| KU59403 | KU59403 is a potent and selective ATM (Ataxia telangiectasia mutated) inhibitor with with potential anticancer activity. KU59403 was not cytotoxic to human cancer cell lines (SW620, LoVo, HCT116, and MDA-MB-231) per se but significantly increased the cytotoxicity of topoisomerase I and II poisons: camptothecin, etoposide, and doxorubicin. Chemo- and radiosensitization by ATM inhibition was not p53-dependent. Following administration to mice, KU59403 distributed to tissues and concentrations exceeding those required for in vitro activity were maintained for at least 4 hours in tumor xenografts. KU59403 significantly enhanced the antitumor activity of topoisomerase poisons in mice bearing human colon cancer xenografts (SW620 and HCT116) at doses that were nontoxic alone and well-tolerated in combination. Chemosensitization was both dose- and schedule-dependent. KU59403 represents a major advance in ATM inhibitor development, being the first compound to show good tissue distribution and significant chemosensitization in in vivo models of human cancer, without major toxicity. KU59403 provides the first proof-of-principle preclinical data to support the future clinical development of ATM inhibitors. Synonyms: KU59403; KU 59403; KU-59403. Grades: 98%. CAS No. 845932-30-1. Molecular formula: C29H32N4O4S2. Mole weight: 564.72. |  |
| KX1-141 | KX1-141 is an Src-protein tyrosine kinase inhibitor, which may reduce cisplatin ototoxicity while preserving its antitumor effect. Synonyms: KX-1-141; KX 1-141; 1H-Indole-2-carboxamide, 7-(3-ethoxyphenyl)-5-fluoro-N-[(3-fluorophenyl)methyl]-. Grades: 98%. CAS No. 1000706-00-2. Molecular formula: C24H20F2N2O2. Mole weight: 406.42. | |
| KY02111 | KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling. Synonyms: N-(6-chlorobenzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide. Grades: >98%. CAS No. 1118807-13-8. Molecular formula: C18H17ClN2O3S. Mole weight: 376.86. | |
| KYA1797K | KYA1797K is a potent, selective and dual inhibitor of Wnt/β-catenin (IC50= 0.75 μM) that significantly decreases reporter activities for the Wnt/β-catenin and MAPK/ERK pathways. Synonyms: potassium;3-[(5Z)-5-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoate. Grades: >98%. CAS No. 1956356-56-1. Molecular formula: C17H11KN2O6S2. Mole weight: 442.51. | |
| L006235 | Potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence. Synonyms: L-006235; L 006235; Benzamide, N-[1-[[ (cyanomethyl) amino]carbonyl]cyclohexyl]-4-[2- (4-methyl-1-piperazinyl) -4-thiazolyl]-. Grades: 98%. CAS No. 294623-49-7. Molecular formula: C24H30N6O2S. Mole weight: 466.60. | |
| L189 | L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. Synonyms: L189; L 189; L-189. Grades: 98%. CAS No. 64232-83-3. Molecular formula: C11H10N4OS. Mole weight: 246.29. | |
| L-2286 | L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury. Synonyms: L 2286; L2286; 2-(2-piperidin-1-ylethylsulfanyl)-1H-quinazolin-4-one. Grades: 98%. CAS No. 684276-17-3. Molecular formula: C15H19N3OS. Mole weight: 289.40. | |
| L-377202 | L-377202 is a prodrug in which a peptide is covalently conjugated with the anthracycline antineoplastic antibiotic doxorubicin. This complex is hydrolyzed by the enzyme prostate-specific antigen (PSA), resulting in the formation of doxorubicin and leucine-doxorubicin. Selective targeting of these drugs to prostate tumor cells occurs because the hydrolyzing PSA enzyme is localized to the prostate gland. Doxorubicin and leucine-doxorubicin intercalate into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. These agents also produce toxic free-radical intermediates and interact with cell membrane lipids causing lipid peroxidation. Synonyms: L 377202; L377202; L-377,202; L 377,202; L377,202; (8S,10S)-10-[[3-[[1-(4-Carboxybutyryl)-t4Hyp-Ala-Ser-[(S)-2-cyclohexyl-Gly-]Gln-Ser-Leu-]amino]-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione. CAS No. 207395-85-5. Molecular formula: C65H89N9O25. Mole weight: 1396.46. | |
| L67 | L67 is a DNA Ligase Inhibitor. L67 inhibited DNA ligases I and III. L67 is a simple competitive inhibitor with respect to nicked DNA. L67 inhibits DNA ligases I and III with IC50 values of 10 μM and 10 μM.). Synonyms: L67; L-67; L 67. Grades: 98%. CAS No. 325970-71-6. Molecular formula: C16H14Br2N4O4. Mole weight: 486.12. | |
| L-744832 | L-744832, also known as L-744,832, is a potent Farnesyltransferase inhibitor with potential anticancer activity. Synonyms: L 744832; L744832; (2S)-2-[[2-[(2S,3S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylpentoxy]-1-oxo-3-phenylpropyl]amino]-4-methylsulfonylbutanoic acid propan-2-yl ester. CAS No. 160141-09-3. Molecular formula: C26H45N3O6S2. Mole weight: 559.78. | |
| L-755507 | L-755,507 is a potent, selective and novel β3-adrenergic receptor (β3-AR) partial agonist with an EC50 value of 0.43 nM. It is over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. It has been used to enhance CRISPR-mediated homology-directed repair efficiency for large fragment insertions and for point mutations at 5 μM in human induced pluripotent stem cells. It also has been used to identify signaling pathways activated through β3-adrenergic receptors. It stimulates lipolysis in rhesus adipocytes in vitro. It may also serve as a potential therapeutic target for the treatment of type II diabetes and obesity. Synonyms: L-755507; L 755507; L755507; 4- [ [ (Hexylamino) carbonyl] amino] -N- [4- [2- [ [ (2S) -2-hydroxy-3- (4-hydroxyphenoxy) propyl] amino] ethyl] phenyl] benzenesulfonamide; (S) -4- [ [ (Hexylamino) carbonyl] amino] -N- [4- [2- [ [2-hydroxy-3- (4-hydroxyphenoxy) propyl] amino] ethyl] phenyl] benzenesulfonamide; 1-Hhexyl-3- [4- [ [4- [2- [ [ (2S) -2-hydroxy-3- (4-hydroxyphenoxy) propyl] amino] ethyl] phenyl] sulfamoyl] phenyl] urea. Grades: ≥98% by HPLC. CAS No. 159182-43-1. Molecular formula: C30H40N4O6S. Mole weight: 584.73. | |
| L-778123 | L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination ofL-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed. Synonyms: L778,123; L-778,123; L 778,123; L 778123; L778123; 1-(3-chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolyl methyl]-2-piperazinone. CAS No. 183499-57-2. Molecular formula: C22H20ClN5O. Mole weight: 405.88. | |
| L-858,051 hydrochloride | L-858,051 is a water-soluble analog of forskolin that acts as an adenylate cyclase activator. It inhibited the 5-HT-stimulated inositol phosphate (IP) accumulation in canine cultured aorta smooth muscle cells (ASMCs). Synonyms: [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] 4-(4-methylpiperazin-1-yl)butanoate dihydrochloride. Grades: ≥95%. CAS No. 115116-37-5. Molecular formula: C29H50N2O8ยท2HCl. Mole weight: 609.6. | |
| Labetuzumab | Labetuzumab is a humanized anti-carcinoembryonic antigen (CEA) monoclonal antibody with antineoplastic activity. Labetuzumab has been used as an adjuvant treatment for colorectal cancer. Synonyms: CEA-CIDE. CAS No. 219649-07-7. | |
| L-Allono-1,4-lactone | L-Allono-1,4-lactone is a compound used in the research of diabetes by regulating blood glucose levels. It functions as an inhibitor of alpha-glucosidase enzyme, thus reducing carbohydrate breakdown and delaying sugar absorption. Synonyms: L-Allono-1,4-lactone; (3S,4R,5S)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyoxolan-2-one; (3S,4R,5S)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxydihydrofuran-2(3H)-one; L-Allonic acid, gamma-lactone; DTXSID401318806. CAS No. 78184-43-7. Molecular formula: C6H10O6. Mole weight: 178.14. | |
| L-Allose | L-Allose, a renowned carbohydrate compound extensively employed in the sphere of biomedical industry, exhibits immense promise in the realm of ameliorating a multitude of ailments, encompassing diabetes and obesity. Researchers have diligently investigated L-Allose owing to its capacity to enhance insulin sensitivity and regulate the intricate mechanisms of glucose metabolism. CAS No. 7635-11-2. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| L-Allose-6-phosphate disodium salt hydrate | L-Allose-6-phosphate disodium salt hydrate is an intriguing compound, serving as a pivotal building block for synthesizing vital metabolic entities. Captivatingly, through its interaction with various molecular targets, it has exhibited auspicious outcomes in studying afflictions such as diabetes and metabolic syndrome. The advantageous inclusion of a disodium salt hydrate configuration augments its solubility and bioavailability. Molecular formula: C6H13O9P Na2 3H2O. Mole weight: 358.15. | |
| L-Altrose | L-Altrose, a distinguished biomedical solution, emerges as an indispensable weapon against a spectrum of diseases. Its extraordinary prowess lies in its profound ability to effectively modulate blood glucose levels, offering new hope to individuals grappling with diabetes. Fascinatingly, the immense therapeutic potential of L-Altrose extends far beyond glycemic regulation. Evidently, it possesses remarkable inhibitory properties that thwart the proliferation of malignant cancer cells, thereby presenting a promising avenue in the battle against certain forms of cancer. CAS No. 1949-88-8. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| Lamivudine-galactose | Lamivudine-galactose is a lamivudine conjugate with galactose. Lamivudine (2',3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir, and Epivir-HBV. Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated. Synonyms: 163-BP3; 163 BP3; 163BP3. Molecular formula: C14H21N3O8S. Mole weight: 422.64. | |
| Laninamivir | Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively. Uses: Antiviral agents. Synonyms: 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid; R 125489; (4S,5R,6R)-5-Acetamido-4-guanidino-6-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid. Grades: 99.91%. CAS No. 203120-17-6. Molecular formula: C13H22N4O7. Mole weight: 346.34. | |
| Laninamivir octanoate | Laninamivir octanoate (CS-8958, R-118958, Inavir, LANI), a prodrug of Laninamivir (R-125489), is a long-acting neuraminidase (NA) inhibitor with superior anti-influenza virus activity. Synonyms: 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid 9-octanoate; (2R,3R,4S)-3-Acetamido-4-guanidino-2-[(1R,2R)-2-hydroxy-1-methoxy-3-(octanoyloxy)propyl]-3,4-dihydro-2H-pyran-6-carboxylic acid; (4S,5R,6R)-5-Acetamido-4-guanidino-6-[(1R,2R)- 2-hydroxy-1-methoxy-3-(octanoyloxy)propyl]-5,6-dihydro-4H-pyran-2-carboxylic acid; CS 8958. Grades: ≥98% (HPLC). CAS No. 203120-46-1. Molecular formula: C21H36N4O8. Mole weight: 472.53. | |
| Laniquidar | Laniquidar is a third-generation P-gp inhibitor, which has been used in clinic trials for modulating multidrug resistance transporters. A study of docetaxel in combination with the new orally administered P-glycoprotein (P-gp) inhibitor R101933showed that this combination was feasible. However, due to the low oral bioavailability ofR101933 and high interpatient variability, no further attempts to increase the level of P-gp inhibition were made. Synonyms: R101933; R 101933; R-101933; methyl 11-(1-(4-(quinolin-2-ylmethoxy)phenethyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carboxylate. CAS No. 197509-46-9. Molecular formula: C37H36N4O3. Mole weight: 584.72. | |
| L-a-Phosphatidyl-(1,2-dipalmitoyl)-D-myo-inositol | L-a-Phosphatidyl-(1,2-dipalmitoyl)-D-myo-inositol, a lipid-based molecule utilized in the biomedicine sector, presents as an intriguing compound due to its neuroprotective characteristics. Its efficacy in improving cognitive function and reducing brain inflammation positions it potentially as a therapeutic agent in Alzheimer's and other neurodegenerative diseases. CAS No. 62742-56-7. Molecular formula: C41H79O13P. Mole weight: 811.03. | |
| L-a-Phosphatidylinositol from Soy bean | L-a-Phosphatidylinositol from Soybean, a naturally occurring phospholipid, boasts a plethora of biomedical applications as it serves as a potent therapeutic agent for an array of ailments including but not limited to cardiovascular diseases, metabolic disorders, and cancer. This compound, with its anti-inflammatory properties, facilitates insulin signaling pathways and preserves cell membranes, hence promoting optimal brain function. The manifold benefits of this compound are a testimony to its profound therapeutic potential. Synonyms: 1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol); Phosphatidylinositols,soya; L-alpha-Phosphatidylinositol from Glycine max (soybean). CAS No. 97281-52-2. Molecular formula: C45H87O13P. Mole weight: 867.1. | |
| L-Apiose | L-Apiose is an organic chemical constituent derived from botanical sources, exhibiting auspicious prospects within the realm of biomedical research and medicinal development. Its multifaceted properties render it a sought-after resource for the design and formulation of pharmacoresearchs targeting an array of afflictions such as neoplastic ailments, metabolic dysfunction and cardiovascular anomalies. CAS No. 6477-44-7. Molecular formula: C5H10O5. Mole weight: 150.13. | |
| L-Arabinaric acid dipotassium salt | L-Arabinaric acid dipotassium salt is an indispensable compound used for studying drug-resistant microbial invasions and pernicious proliferation of malignant cells. Synonyms: Dipotassium L-arabinarate; Dipotassium L-lyxarate. CAS No. 608-54-8. Molecular formula: C5H6K2O7. Mole weight: 256.29. | |
| L-Arabinopyranosyl thiosemicarbazide | L-Arabinopyranosyl thiosemicarbazide is a remarkable compound with anticancer properties. It displays impressive efficacy in impeding the proliferation of select cancer cells. Synonyms: L-Arabinose (aminothioxomethyl)hydrazone; N-L-arabinopyranosyl-hydrazinecarbothioamide. CAS No. 262849-63-8. Molecular formula: C6H13N3O4S. Mole weight: 223.25. | |
| L-Arabinose-BSA | | |
| L-Arabinose diethyldithioacetal | L-Arabinose diethyldithioacetal is a biomedical product utilized for various purposes in the industry. This compound is studied for its potential therapeutic applications in cancer treatment, particularly in combination with certain anti-tumor drugs. Its unique structure and properties make L-Arabinose diethyldithioacetal a promising candidate for targeted drug delivery systems and enhancing the efficacy of existing cancer medications. CAS No. 43179-48-2. Molecular formula: C9H20O4S2. Mole weight: 256.38. | |
| L-Arabinose hydrazone | L-Arabinose hydrazone is a valuable compound employed in the biomedical industry. It exhibits promising potential in the treatment of certain diseases and drug development. Through its effective binding properties, L-Arabinose hydrazone assists in targeting and combating specific drug compounds or diseases, offering potential therapeutic benefits. Synonyms: L-Arabinose, hydrazone(9CI); (2S,3R,4S,5E)-5-hydrazinylidenepentane-1,2,3,4-tetrol. CAS No. 816-01-3. Molecular formula: C5H10N2O4. Mole weight: 162.14. | |
| L-Arabinose - Syrup | L-Arabinose - Syrup is a superior biomedicalcompound, aiding in studying the relentless menace of diabetes. | |
| L-Arabonic acid-1,4-lactone | L-Arabonic acid-1,4-lactone, a widely-utilized biomedical compound in the pharmaceutical sector, plays a crucial role as a precursor for synthesizing diverse drugs ranging from antiviral agents to anticancer treatments. Synonyms: L-Arabino-1,4-lactone; L-arabinonic acid gamma-lactone; (3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one. Grades: ≥95%. CAS No. 51532-86-6. Molecular formula: C5H8O5. Mole weight: 148.11. | |
| L(-)-Arabonic acid calcium salt tetrahydrate | L(-)-Arabonic acid calcium salt tetrahydrate is a significant compound functioning as a pivotal intermediate in the synthesis of pharmaceutical drugs aimed at studying diabetes, cancer and cardiovascular disorders. Through its ability to regulate glucose metabolism, hinder tumor growth and enhance cardiac well-being, its efficacy has been meticulously examined and extensively recorded. Consequently, it stands as an invaluable component within the realms of biomedical research and drug advancement. Synonyms: Calcium-L(-)-arabonate. | |
| Largazole | Largazole is a novel histone deacetylase (HDAC) inhibitor. Screening against the National Cancer Institute's 60 cell lines revealed that largazole is particularly active against several colon cancer cell types. Largazole inhibits HDACs in tumor tissue in vivo. Largazole strongly stimulated histone hyperacetylation in the tumor, showed efficacy in inhibiting tumor growth, and induced apoptosis in the tumor. This effect probably is mediated by the modulation of levels of cell cycle regulators, antagonism of the AKT pathway through insulin receptor substrate 1 down-regulation, and reduction of epidermal growth factor receptor levels. Synonyms: (+)-Largazole; S-((E)-4-((12Z,22Z,24R,5S,8S)-5-isopropyl-24-methyl-3,6,10-trioxo-24,25-dihydro-7-oxa-4,11-diaza-1(4,2),2(2,4)-dithiazolacyclododecaphane-8-yl)but-3-en-1-yl) octanethioate. CAS No. 1009815-87-5. Molecular formula: C29H42N4O5S3. Mole weight: 622.86. | |
| LAS191859 | LAS191859 is a potent antagonist of chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTh2), a G protein-coupled receptor most expressed on the leukocytes. LAS191859 is identified as a treatment of asthma and allergy. Synonyms: 1-[2-[[ (cyclopropylcarbonyl) ethylamino]methyl]-4- (trifluoromethyl) phenyl]-6-methyl-1H-pyrrolo[2, 3-b]pyridine-3-aceticacid. Grades: ≥98%. CAS No. 1420071-13-1. Molecular formula: C24H24F3N3O3. Mole weight: 459.5. | |
| Lasofoxifene glucuronide | A metabolite of Lasofoxifene in humans. Synonyms: (5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalen b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 1048953-95-2. Molecular formula: C34H39NO8. Mole weight: 589.68. | |
| LB-102 | LB-102 is a derivative of benzamide. It is potentially used to treat psychosis with an enhanced ability of penetrating the blood brain barrier. Uses: Potential psychotropic medication. Synonyms: N'-Methylamisulpride; N'-Methyl amisulpride; LB 102; LB102; 4-methylamino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl))-2-methoxybenzamide. Molecular formula: C18H29N3O4S. Mole weight: 383.50. | |
| LB-103 | LB-103 is an S-enantiomer of LB-102, a derivative of benzamide, which is promisingly to be a psychotropic drug. Uses: Potential psychotropic medication. Synonyms: LB 103; LB103. CAS No. 2227154-25-6. Molecular formula: C18H29N3O4S. Mole weight: 383.50. | |
| LB42708 | LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation. Synonyms: LB-42708; LB 42708; (1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone. Grades: 98%. CAS No. 226929-39-1. Molecular formula: C30H27BrN4O2. Mole weight: 555.47. | |
| LB42908 | LB42908 is a highly potent Ras farnesyltransferase inhibitor(IC(50)=0.9 nM against H-Ras and 2.4 nM against K-Ras) with potential anticancer activity. Synonyms: LB-42908; LB 42908; (1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(4-methylpiperazin-1-yl)methanone. Grades: 98%. CAS No. 226927-89-5. Molecular formula: C32H31N5O3. Mole weight: 533.62. | |
| LBW242 | LBW242 is a Smac mimetic, and potent IAP inhibitor. LBW242 is effective against mutant FLT3 at doses that are physiologically achievable and well tolerated in vivo. LBW242 also enhances the inhibitory effects of PKC412, as well as standard chemotherapeutic agents such as doxorubicin and Ara-c, by acting in an additive-synergistic fashion against mutant FLT3-expressing cells in vitro. LBW242 also sensitizes ovarian cancer cells to the antitumor effects of TRAIL and anticancer drugs commonly used in clinic. Synonyms: N-{(1S)-1-Cyclohexyl-2-oxo-2-[(3aR,7aS)-6-(2-phenylethyl)octahydro-1H-pyrrolo[2,3-c]pyridin-1-yl]ethyl}-N2-methyl-L-alaninamide; Propanamide, N-[(1S)-1-cyclohexyl-2-[(3aR,7aS)-octahydro-6-(2-phenylethyl)-1H-pyrrolo[2,3-c]pyridin-1-yl]-2-oxoethyl]-2-(methylamino)-, (2S)-; (S)-N-((S)-1-cyclohexyl-2-oxo-2-((3aR,7aS)-6-phenethyloctahydro-1H-pyrrolo[2,3-c]pyridin-1-yl)ethyl)-2-(methylamino)propanamide. Grades: ≥95%. CAS No. 867324-12-7. Molecular formula: C27H42N4O2. Mole weight: 454.65. | |
| LCH-7749944 | LCH-7749944, also known as GNF-Pf-2356, is a novel and potent PAK4 inhibitor, which effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway. In addition, LCH-7749944 significantly inhibited the migration and invasion of human gastric cancer cells in conjunction with concomitant blockage of PAK4/LIMK1/cofilin and PAK4/MEK-1/ERK1/2/MMP2 pathways. Synonyms: LCH-7749944; N2-(3-Methoxyphenyl)-N4-((tetrahydrofuran-2-yl)methyl)quinazoline-2,4-diamine; GNF-Pf-2356. Grades: ≥98%. CAS No. 796888-12-5. Molecular formula: C20H22N4O2. Mole weight: 350.41. | |
| LCI699 | LCI699 is a potent inhibitor of 11β-hydroxylase, the enzyme which catalyzes the final step of cortisol synthesis. LCI699 may thus be a potential new treatment for all forms of Cushing's syndrome. Synonyms: LCI 699; LCI-699; Benzonitrile, 4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluoro-. CAS No. 928134-31-0. Molecular formula: C13H10FN3. Mole weight: 227.24. | |
| L-Daunosamine | L-Daunosamine is a semi-synthetic anthracycline antibiotic found in Streptomyces peucetius. Synonyms: L-lyxo-Hexose, 3-amino-2,3,6-trideoxy-; Daunosamine; 3-Amino-2,3,6-trideoxy-L-lyxo-hexose. Grades: ≥95%. CAS No. 26548-47-0. Molecular formula: C6H13NO3. Mole weight: 147.17. | |
| L-Daunosamine-b-methylglycoside hydrochloride | L-Daunosamine-b-methylglycoside hydrochloride is an indispensable compound of paramount importance within the biomedical sector assuming a pivotal function in the intricate synthesis of robust anticancer formulations, exemplified by daunorubicin and idarubicin. Synonyms: Methyl L-daunosamine HCl. Molecular formula: C7H15NO3 HCl. Mole weight: 197.66. | |
| L-Daunosamine, Hydrochoride | Cas No. 105497-63-0. | |
| LDE-225 Diphosphate | LDE225 Diphosphate (NVP-LDE225; Erismodegib) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. Synonyms: LDE 225 Diphosphate; LDE225 Diphosphate; Sonidegib phosphate; Erismodegib Diphosphate. CAS No. 1218778-77-8. Molecular formula: C26H32F3N3O11P2. Mole weight: 681.49. | |
| L-Dehydro ascorbic acid | L-Dehydro ascorbic acid, an indispensable component within the realm of the biomedical industry, garners significant attention owing to its remarkable antioxidative attributes. Frequently applied in the amelioration of vitamin C insufficiency and an assortment of ailments linked to oxidative stress, this potent substance assumes a pivotal function in fortifying the immune system and fostering holistic well-being. Its exceptional affinity for bodily absorption accentuates its significance, rendering it an invaluable compound of great merit. Uses: Vitamins. Synonyms: Dehydro-L-ascorbic acid; L-threo-2,3-hexodiulosonic acid gamma-lactone; Oxidized ascorbic acid. CAS No. 490-83-5. Molecular formula: C6H6O6. Mole weight: 174.11. | |
| LDN-212320 | LDN-212320 is a glutamate transporter EAAT2 activator. It increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells and displays neuroprotective activity in vivo. It is shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice. Synonyms: LDN/OSU-0212320; LDN-0212320; OSU-0212320; LDN-212320; LDN 212320; LDN212320. Grades: >98%. CAS No. 894002-50-7. Molecular formula: C17H15N3S. Mole weight: 293.39. | |
| LDN-214117 | LDN-214117 is a potent and selective ALK2 inhibitor (IC50 = 24nM). It shows selectivity for ALK2 and ALK1 over ALK3, and exhibits 164-fold selectivity for BMP6 inhibition (IC50 = 100 nM) over TGF-β1. Synonyms: LDN 214117; 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine. Grades: >98%. CAS No. 1627503-67-6. Molecular formula: C25H29N3O3. Mole weight: 419.52. | |
| Lebrikizumab | Lebrikizumab is a humanized monoclonal antibody that binds to IL-13. Lebrikizumab has the potential for the treatment of atopic dermatitis (AD). CAS No. 953400-68-5. | |
| Ledoxantrone | Ledoxantrone, also known as sedoxantrone or CI-958, is an anthrapyrazole antineoplastic antibiotic molecule with potential antineoplastic activity. Sedoxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Synonyms: Ledoxantrone; sedoxantrone; CI-958; CI 958; CI958. CAS No. 113457-05-9. Molecular formula: C21H27N5OS. Mole weight: 397.54. | |
| Lemuteporfin | Lemuteporfin , a diester derivative of benzoporphyrin derivative, is a neutral, uncharged benzoporphyrin molecule having symmetrical diethylene glycol groups; this maintains its amphiphilic character. Synonyms: QLT0074; QLT 0074; QLT-0074; EA 6; Dimethyl (2RS,21SR)-8-ethenyl-13,17-bis(3-(2-hydroxyethoxycarbonyl)-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo(b)porphyrin-21,22-dicarboxylate. CAS No. 215808-49-4. Molecular formula: C44H48N4O10. Mole weight: 792.88. | |
| Lemzoparlimab | Lemzoparlimab is a humanized anti-CD47 monoclonal antibody. Lemzoparlimab has been used in the research of relapsed/refractory malignancy. Synonyms: TJ011133; TJC4. CAS No. 2377483-71-9. | |
| Lenzilumab | Lenzilumab is a humanized monoclonal antibody targeting colony stimulating factor 2 (CSF2)/granulocyte-macrophage colony stimulating factor (GM-CSF). Lenzilumab has the potential for the treatment of COVID-19. Synonyms: KB 003; KB003; KB-003. CAS No. 1229575-09-0. | |
| Lerisetron | Lerisetron is a serotonin type 3 (5-HT3) receptor antagonist with antiemetic activity. Lerisetron specifically binds to 5-HT3 receptors, located peripherally on vagus nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, which may result in suppression of chemotherapy-induced nausea and vomiting. Synonyms: 1-Benzyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole; 1-benzyl-2-(piperazin-1-yl)-1H-benzimidazole. CAS No. 143257-98-1. Molecular formula: C18H20N4. Mole weight: 292.39. | |
| L-Erythrono-1,4-lactone | It is a potential α-glucosidase inhibitor. Synonyms: L-Erythronic acid gamma-lactone; L-Erythronic acid, γ-lactone; (3S,4S)-3,4-Dihydroxydihydrofuran-2(3H)-one; L-Erythronolactone; L-Erythronic acid 1,4-lactone. Grades: >97%. CAS No. 23732-40-3. Molecular formula: C4H6O4. Mole weight: 118.09. | |
| L-Erythrose | L-Erythrose is an intriguing bioactive compound, acting as a prevalent precursor in therapeutic drug syntheses. Synonyms: L-Erythrose; 533-49-3; L-(+)-Erythrose; (2S,3S)-2,3,4-trihydroxybutanal; L-erythro-tetrose; Butanal, 2,3,4-trihydroxy-, (2S,3S)-; 96DH71781X; Erythrose, L-; L(+)-Erythrose; UNII-96DH71781X; EINECS 208-567-8; (+)-ERYTHROSE; L-ERYTHROSE [MI]; SCHEMBL424699; CHEBI:21288; DTXSID30201447; YTBSYETUWUMLBZ-DMTCNVIQSA-N; MFCD00064377; AKOS016844119; HY-116956A; AS-83567; L-Erythrose (~0.1 M solution in water); CS-0139803; A870746; W-203013; Q27109384. CAS No. 533-49-3. Molecular formula: C4H8O4. Mole weight: 120.1. | |
| L-Erythrulose | L-Erythrulose is a prominent compound widely used in the cosmetic industry for its self-tanning properties. This colorless ketose sugar reacts with the amino acids in the skin's outermost layer to produce a natural, long-lasting tan, making it a sought-after ingredient in self-tanning lotions and sprays. Synonyms: L-Erythrulose; 533-50-6; L-glycero-Tetrulose; L-(+)-Erythrulose; (3S)-1,3,4-trihydroxybutan-2-one; (3S)-1,3,4-Trihydroxy-2-butanone; UNII-WKK1W5B83O; WKK1W5B83O; (S)-1,3,4-Trihydroxybutan-2-one; 2-Butanone, 1,3,4-trihydroxy-, (3S)-; ERYTHRULOSE, L-; FM-MH; ERYTHRULOSE [INCI]; L-ERYTHRULOSE [MI]; ERYTHRULOSE, (+)-; SCHEMBL439347; CHEBI:27913; UQPHVQVXLPRNCX-VKHMYHEASA-N; DTXSID801019042; BCP10464; MFCD00004703; AKOS028108990; 2-Butanone,1,3,4-trihydroxy-,(3S)-; L-(+)-Erythrulose, >=85% (HPLC); CS-0436802; C02045; EN300-7592871; W-203014; Q27103403; Erythrulose, Pharmaceutical Secondary Standard; Certified Reference Material. CAS No. 533-50-6. Molecular formula: C4H8O4. Mole weight: 120.1. | |
| Letaxaban | Letaxaban, also known as TAK-442, is a potent, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. TAK-442inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442] and rat (IC(50): 32 nM, TAK-442) plasma. TAK-442 inhibited in vitro reconstituted human prothrombinase (system included FXa, calcium, and washed platelets) with an IC(50) value of 51 nM. In a rat model of balloon injury, thrombin activity on the surface of injured vessels increased to 3.2-, 22-, and 5.8-fold the activity on the surface of the intact aorta at 5 minutes, 1 hour, and 24 hours after the injury, respectively. At approximately 1 hour after the injury, TAK-442 blocked platelet-associated thrombin generation on the surface of injured aortas with an IC(50) value of 19 nM. Uses: Factor xa inhibitors. Synonyms: TAK-442; TAK 442; TAK442; (S)-1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one. CAS No. 870262-90-1. Molecular formula: C22H26ClN3O5S. Mole weight: 479.98. | |
| Levofloxacin-Acyl-D-Glucuronide | An impurity of Levofloxacin, which is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Synonyms: 1-[(3S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate]-b-D-glucopyranuronic acid; Levofloxacin glucuronide. Grades: > 95%. CAS No. 160962-46-9. Molecular formula: C24H28FN3O10. Mole weight: 537.49. | |
| Levoglucosan | Cas No. 498-07-7. | |
| Levothyroxine acyl glucuronide | a major metabolite and glucuronide conjugate of Thyroxine. Synonyms: Thyroxine Acyl-β-D-Glucuronide; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine β-D-Glucopyranuronosyl Ester. Grades: > 95%. CAS No. 909880-81-5. Molecular formula: C21H19I4NO10. Mole weight: 953.00. | |
| LF3 | LF3 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 1.65 μM), but does not interfere with E-cadherin/β-catenin-mediated cell-cell adhesion.antitumor activity. Synonyms: LF3; LF 3; LF-3; 4-[(E)-3-phenylprop-2-enyl]-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide; ST50763308; 4-[(2E)-3-phenylprop-2-en-1-yl]-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide; AC1LO36F. Grades: >98%. CAS No. 664969-54-4. Molecular formula: C20H24N4O2S2. Mole weight: 416.56. | |
| L-Fructose | L-Fructose, a prominent natural monosaccharide cherished in the thriving biomedical realm, stands as a pivotal element for cellular energy production. In the grand orchestration of nucleotide and glycolipid synthesis, its indispensability prevails. Synonyms: L-(+)-Fructose. CAS No. 7776-48-9. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| L-Fucal | L-Fucal is an extensively occurring bioactive compound present in several seaweeds, exhibiting remarkable anti-inflammatory characteristics. It contributes to the progression of researchs targeting chronic inflammatory ailments, including rheumatoid arthritand inflammatory bowel disease. Synonyms: (2S,3S,4S)-2-Methyl-3,4-dihydro-2H-pyran-3,4-diol. CAS No. 80483-16-5. Molecular formula: C6H10O3. Mole weight: 130.14. | |
| L-Fucono-1,4-lactone | L-Fucono-1,4-lactone, an indispensable bioactive compound extensively utilized in the biomedical sector, demonstrates remarkable potency. This compound holds immense potential for addressing diverse ailments associated with oxidative stress and inflammation, rendering it a ubiquitous choice in therapeutic interventions. Its antioxidative characteristics enable L-Fucono-1,4-lactone to efficaciously combat ailments like diabetes, liver pathologies, and neurodegenerative disorders. Synonyms: L-Fuconic acid gamma-lactone; 6-deoxy-L-galactonic acid gamma-lactone. CAS No. 24286-28-0. Molecular formula: C6H10O5. Mole weight: 162.14. | |
| L-Fucose | L-Fucose is a natural sugar primarily utilized in biomedicine as a potential therapeutic for various diseases and disorders. It has shown promise in cancer treatment, as it inhibits tumor growth and metastasis. L-Fucose also plays a vital role in modulating the immune response, making it valuable in autoimmune disorders. Furthermore, it acts as a precursor for the synthesis of glycoproteins, aiding in the treatment of certain genetic disorders. Synonyms: 6-Deoxy-L-galactose; L-(-)-Rhodeose. CAS No. 6696-41-9. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| L-Fucose-1-phosphate disodium salt | L-Fucose-1-phosphate disodium salt, a pivotal constituent in biomedical investigation, stands as a fundamental substrate for diverse enzymatic activities implicated in myriad biological phenomena. Its indispensability arises from its pivotal involvement in comprehending and scrutinizing the intricate metabolic pathways of L-fucose, an omnipresent saccharide within mammalian cellular matrices. Synonyms: 6-Deoxy-L-galactose-1-phosphate disodium salt. CAS No. 374726-44-0. Molecular formula: C6H11Na2O8P. Mole weight: 288.1. | |
| L-Fucose (AS) | L-Fucose (AS) is a pivotal biomolecule widely employed industry, playing a vital role in the development of drugs targeting diverse diseases. L-Fucose (AS) exhibits remarkable adaptability in studying a broad spectrum of diseases encompassing cancer, inflammation, neurological disorders. Synonyms: L-(-)-Fucose; 2438-80-4; (2S,3R,4R,5S)-2,3,4,5-tetrahydroxyhexanal; L-Galactose, 6-deoxy-; aldehydo-L-fucose; L-(-)-Rhodeose; 3h-fucose; 28RYY2IV3F; MFCD00135607; L(-)-Fucose; Elfucose; L-Rhodeose; L-(-)-Flucose; L-(?)-Fucose; ELFUCOSE [USAN]; FUCOSE [INCI]; L-FUCOSE [MI]; L-FUCOSE [USP-RS]; SCHEMBL21209; GTPL4721; CHEBI:48204; DTXSID50883845; L-(-)-Fucose, >=99%; PNNNRSAQSRJVSB-KCDKBNATSA-N; HY-N1480; s9002; ZB1881; AKOS015919077; CCG-266306; DB15236; AC-34938; DS-10931; CS-0016990; F0065; L-Fucose, United States Pharmacopeia (USP) Reference Standard. Grades: 98%. CAS No. 2438-80-4. Molecular formula: C6H12O5. Mole weight: 164.16. | |
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