BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Ibalizumab | Ibalizumab is a humanized anti-CD4 monoclonal antibody approved for the treatment of HIV-1 infection. Ibalizumab blocks HIV-1 entry into CD4 cells while preserving normal immune function. Synonyms: TMB-355; TNX-355; Trogarzo. CAS No. 680188-33-4. |  |
| I-BET 151 dihydrochloride | The hydrochloride salt form of I-BET 151, which has been found to be a BET bromodomain inhibitor and exhibit activities against human and murine MLL-fusion leukaemic cell lines. Synonyms: I-BET 151 dihydrochloride; I BET 151 dihydrochloride; IBET 151 dihydrochloride; IBET151 dihydrochloride; 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1883545-47-8. Molecular formula: C23H21N5O3.2HCl. Mole weight: 488.37. | |
| Ibiglustat | Ibiglustat is a selective Glucosylceramide synthase inhibitor. It can block the formation of glucosylceramide (GL-1) which is a key intermediate in the synthesis of GL-3. In Oct 2016, Genzyme completed a phase II trial in Fabry's disease (Treatment-naïve) in USA, Czech Republic, France, Poland, Russia and the UK. Phase-II clinical trials in Gaucher's disease in USA is on-going. Uses: Fabry's disease; gaucher's disease. Synonyms: GZ-402671; GZ402671; GZ 402671; SSAR402671; SAR-402671; SAR 402671; Genz-682452-AA; Ibiglustat; GZ-452; Genz-682452; GZ 452; Genz 682452; GZ452; Genz682452; (3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)- 1,3-thiazol-4-yl]propan-2-yl}carbamate. Grades: 98%. CAS No. 1401090-53-6. Molecular formula: C20H24FN3O2S. Mole weight: 389.49. | |
| IBMX | IBMX is an inhibitor of cAMP and cGMP phosphodiesterases. IBMX was shown to promote differentiation of 3T3-L1 cells in combination with insulin and dexamethasone. It also induces neural transdifferentiation of mesenchymal stem cells (MSCs) through downregulation of the NRSF. Uses: Phosphodiesterase inhibitors. Synonyms: 3-Isobutyl-1-methylxanthine; isobutylmethylxanthine; 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione. Grades: >98%. CAS No. 28822-58-4. Molecular formula: C10H14N4O2. Mole weight: 222.24. | |
| Ibulocydine | Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibulocydine rapidly blocked phosphorylation of the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II, a process mediated by Cdk7/9. Anti-apoptotic gene products such as Mcl-1, survivin, and X-linked IAP (XIAP) are crucial for the survival of many cell types, including HCC. Following the inhibition of RNA polymerase II phosphorylation, ibulocydine caused rapid down-regulation of Mcl-1, survivin, and XIAP, thus inducing apoptosis. Furthermore, ibulocydine effectively induced apoptosis in HCC xenografts with no toxic side effects. These results suggest that ibulocydine is a strong candidate anti-cancer drug for the treatment of HCC. Synonyms: Ibulocydine. Grades: 98%. CAS No. 1314096-68-8. Molecular formula: C16H20BrN5O6. Mole weight: 458.26. | |
| Ibuprofen Acyl-beta-D- Glucuronide | Ibuprofen Acyl-beta-D-Glucuronide is an essential metabolite derived from ibuprofen, serving as a pivotal constituent in the synthesis of nonsteroidal anti-inflammatory drugs. Synonyms: Ibuprofen glucuronide; (2S, 3S, 4S, 5R, 6S) -3, 4, 5-Trihydroxy-6-[2- (4-Isobutylphenyl) Propanoyloxy]Tetrahydropyran-2-Carboxylic Acid; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[2-(4-Isobutylphenyl)-1-Oxopropoxy]-2-Tetrahydropyrancarboxylic Acid; Ibuprofen Acyl Glucuroni. Grades: > 95%. CAS No. 115075-59-7. Molecular formula: C19H26O8. Mole weight: 382.40. | |
| Ibutamoren | Ibutamoren, also known as MK-677 (L-163,191), is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity. Synonyms: L 163191; L-163191; L163191; MK-0677; MK0677; MK 0677; (R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide. CAS No. 159634-47-6. Molecular formula: C27H36N4O5S. Mole weight: 528.67. | |
| IC86621 | IC86621 is potent DNA-Pk inhibitor with potential anticancer activity. Synonyms: IC-86621; IC 86621; Ethanone, 1-[2-hydroxy-4-(4-morpholinyl)phenyl]-; DNA-PK Inhibitor III. Grades: 98%. CAS No. 404009-40-1. Molecular formula: C12H15NO3. Mole weight: 221.26. | |
| ICG-001 | ICG-001 is an antagonist of Wnt/β-catenin/TCF-mediated transcription and binds to cyclic AMP responsive element binding-binding protein (CBP)-mediated transcription with IC50 value of 3 μM. ICG-001 has been demonstrated to inhibit gastric cancer cell growth and reduce chemoresistance of cancer stem cell-like population. Synonyms: ICG 001; (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide. Grades: >98%. CAS No. 780757-88-2. Molecular formula: C33H32N4O4. Mole weight: 548.63. | |
| ICI-118551 HCl | A highly selective antagonist for the β2 adrenergic receptors. Binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively). Synonyms: ICI-118551; ICI118551; ICI 118551; ICI-118,551; ICI118,551; ICI 118,551. Grades: 98%. CAS No. 72795-19-8. Molecular formula: C17H28ClNO2. Mole weight: 313.866. | |
| ID-11014A | ID-11014A is a potent and selective agonist of GPR40 (free fatty acid receptor 1) that can increase insulin secretion and reduce glucose levels. Studies shows that it has a lower liver toxicity than TAK-785 and an improved glucose tolerance. Uses: The potential treatment of diabetes. Synonyms: ID 11014A. | |
| ID-8 | ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. Synonyms: ID-8; ID 8; ID8. Grades: >98%. CAS No. 147591-46-6. Molecular formula: C16H14N2O4. Mole weight: 298.29. | |
| IDN-1965 | IDN-1965 is a potent, broad-spectrum, irreversible caspase inhibitor. IDN-1965 is markedly effective at inhibiting Fas-mediated apoptosis by multiple routes of administration. The therapeutic potential of caspase inhibitors appears promising for the treatment of apoptosis-mediated liver injury based on potency and postinsult efficacy. Synonyms: IDN1965; IDN 1965; N-[(1,3-Dimethylindole-2-Carbonyl)Valinyl]-3-Amino-4-Oxo-5-Fluoropentanoic Acid; 3-((S)-2-(1,3-dimethyl-1H-indole-2-carboxamido)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acid. Grades: 98%. CAS No. 204919-14-2. Molecular formula: C21H26FN3O5. Mole weight: 419.45. | |
| Idoxifene | Idoxifene is a non-steroidal estrogen antagonist. It is also structurally analogous to tamoxifen. Idoxifene was both active and well tolerated in postmenopausal women with metastatic breast cancer. Idoxifene had similar efficacy and toxicity to tamoxifen in this randomized comparison. Synonyms: CB7432; 1-[2-[4-[(1E)-1-(4-Iodophenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]-pyrrolidine; trans-1-(4-Iodophenyl)-1-(4-(2'-pyrrolidinoethoxy)phenyl)-2-phenylbutene; (E)-1-[2-[4-[1-(4-iodophenyl)-2-phenyl-1-butenyl]phenoxy]ethyl]-pyrrolidine; SB 223030. Grades: ≥95%. CAS No. 116057-75-1. Molecular formula: C28H30INO. Mole weight: 523.45. | |
| IEM 1754 dihydrobromide | IEM 1754 causes use- and voltage-dependent block of open channels of recombinant AMPA receptors. Synonyms: IEM-1754 dihydrobromide; IEM1754 dihydrobromide; IEM-1754 2HBr; IEM 1754 2HBr; IEM1754 2HBr; N-(Tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1,5-pentanediamine dihydrobromide. Grades: >98%. CAS No. 162831-31-4. Molecular formula: C16H32Br2N2. Mole weight: 412.25. | |
| Ieramilimab | Ieramilimab is a humanized monoclonal antibody that binds to LAG-3. Ieramilimab has been investigated as a cancer therapy. Synonyms: LAG525; IMP701. CAS No. 2137049-37-5. | |
| IG-105 | IG-105 is a potent microtubule inhibitor with potential anticancer activity. IG-105 inhibits microtubule assembly by binding at colchicine pocket. IG-105 shows a potent anticancer activity in vitro and in vivo and has good safety in mice. IG-105 showed a potent activity against human leukemia and solid tumors in breast, liver, prostate, lung, skin, colon, and pancreas with IC(50) values between 0.012 and 0.298 mumol/L. It was also active in drug-resistant tumor cells and not a P-glycoprotein substrate. It inhibited microtubule assembly followed by M-phase arrest, Bcl-2 inactivation, and then apoptosis through caspase pathways. Synonyms: IG105; IG 105. Grades: 98%. CAS No. 905978-63-4. Molecular formula: C20H19N3O4S. Mole weight: 397.45. | |
| IHMT-PI3Kδ-372 S-isomer | An S isomer of IHMT-PI3Kδ-372, a potent and selective PI3Kδ inhibitor used for the treatment of chronic obstructive pulmonary disease. Synonyms: 2-[(1S)-1-[4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoro-4(3H)-quinazolinone. CAS No. 2429889-61-0. Molecular formula: C26H23F2N7O2. Mole weight: 503.5. | |
| IITZ-01 | IITZ-01 is a potent autophagy inhibitor that is accumulated in lysosomes. IITZ-01 exhibited anticancer effects in MDA-MB-231 breast cancer xenograft model. Synonyms: EX-A2763; HY-112897; AK00792538; 4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine. CAS No. 1807988-47-1. Molecular formula: C26H23FN8O. Mole weight: 482.51. | |
| IKK-16 HCl | Cas No. 1186195-62-9. | |
| IM-12 | IM-12 is a potent and selective GSK3β inhibitor with IC50 value of 53 nM. It has been shown to promote neuronal differentiation in neural progenitor cells, and support the conversion and maintenance of human naive stem cells. Synonyms: IM 12; 3-(4-fluorophenethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Grades: >98%. CAS No. 1129669-05-1. Molecular formula: C22H20FN3O2. Mole weight: 377.41. | |
| Imexon | Imexon is a cyanoaziridine derivatives with potential anticancer activity. Imexon belongs to a novel class of promising anticancer agents that induce tumor apoptosis through oxidative stress. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. Synonyms: AIDS000351; AIDS-000351; AIDS 000351; BM06002; BM 06002; BM-06002; 4-Imino-1,3-diazabicyclo-[3.1.0]hexan-2-one. CAS No. 59643-91-3. Molecular formula: C4H5N3O. Mole weight: 111.10. | |
| iminosugar 1 | | |
| iminosugar 2 | | |
| Imipramine N-Glucuronide | A metabolite of Imipramine. Synonyms: N-b-D-Glucopyranuronosyl-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanaminium inner salt. Grades: > 95%. CAS No. 165602-94-8. Molecular formula: C25H32N2O6. Mole weight: 456.53. | |
| Imraldi | | |
| IMS 2186 | IMS 2186 is an anti-proliferative and anti-angiogenic compound developed as an anti-choroidal neovascularization (anti-CNV) drug. It inhibits the cell cycle at G2 and the production of PGE2/TNF-&alpha. Uses: Anti-cnv drug. Synonyms: IMS2186; IMS-2186; 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one. Grades: 99%. CAS No. 1031206-36-6. Molecular formula: C18H16O4. Mole weight: 296.32. | |
| INCB16562 | INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB16562 abrogated the protective effects of recombinant cytokines or bone marrow stromal cells and sensitized myeloma cells to cell death by exposure to dexamethasone, melphalan, or bortezomib. Oral administration of INCB16562 antagonized the growth of myeloma xenografts in mice and enhanced the antitumor activity of relevant agents in combination studies. INCB16562 is a potent JAK1/2 inhibitor and that mitigation of JAK/STAT signaling by targeting JAK1 and JAK2 will be beneficial in the treatment of myeloma patients, particularly in combination with other agents. Synonyms: INCB-16562; INCB 16562; 2-(2,6-dichlorophenyl)-1,8-dihydroimidazo[4,5-d]dipyrido[2,3-b:4',3'-f]azepine. CAS No. 933768-63-9. Molecular formula: C19H11Cl2N5. Mole weight: 380.23. | |
| Incyclinide | incyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and achemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis. Synonyms: Metastat; 4-dedimethylamino sancycline; CMT-3; CMT 3; CMT3; COL 3; COL3; COL-3. CAS No. 15866-90-7. Molecular formula: C19H17NO7. Mole weight: 371.34. | |
| Indacrinone | Indacrinone is a loop diuretic. It can be used as an antihypertensive in patients of gout with hypertension because it decreases reabsorption of uric acid. Uses: Indacrinone can be used as an antihypertensive in patients of gout with hypertension. Synonyms: Indacrinic acid; Indacrynic acid; MK-196; MK 196; MK196; [(6,7-Dichloro-2-methyl-1-oxo-2-phenyl-2,3-dihydro-1H-inden-5-yl) oxy]acetic acid. Grades: 98%. CAS No. 57296-63-6. Molecular formula: C18H14Cl2O4. Mole weight: 365.21. | |
| Indeloxazine hydrochloride | Indeloxazine hydrochloride acts as a norepinephrine reuptake inhibitor, serotonin releasing agent and NMDA receptor antagonist. It is used as an antidepressant and cerebral activator. It has been found to possess neuroprotective, nootropic, anticonvulsant and antidepressant-like effects in animal models. It could enhance acetylcholine release in the rat forebrain through activation of the 5-HT4 receptor. Uses: Indeloxazine hydrochloride is used as an antidepressant and cerebral activator. it has been found to possess neuroprotective, nootropic, anticonvulsant and antidepressant-like effect. Synonyms: Indeloxazine HCl; 2-((1H-Inden-7-yloxy)methyl)morpholine hydrochloride; CI-874; CI 874; Elen; YM-08054-1. Grades: 98%. CAS No. 65043-22-3. Molecular formula: C14H18ClNO2. Mole weight: 267.75. | |
| Indimitecan | Indimitecan is a novel topoisomerase I inhibitor. Synonyms: LMP776; LMP-776; LMP 776; 5H-(1,3)Dioxolo(4',5':5,6)indeno(1,2-c)isoquinoline-5,12(6H)-dione, 6-(3-(1H-imidazol-1-xyl)propyl)-2,3-dimethoxy-. CAS No. 915360-05-3. Molecular formula: C25H21N3O6. Mole weight: 459.46. | |
| Indole-3-acetyl β-D-Glucopyranose | A metabolite of Indole-3-acetic acid in plants. Uses: A metabolite of indole-3-acetic acid. Synonyms: 1-(1H-Indole-3-acetate) β-D-Glucopyranose; 1-O-(Indol-3'-ylacetyl)-β-D-glucopyranose; Indole-3-acetic Acid β-D-Glucopyranosyl Ester; Indole-3-acetic Acid β-Glucoside. CAS No. 19817-95-9. Molecular formula: C16H19NO7. Mole weight: 337.32. | |
| Indole-3-butanoyl β-D-Glucopyranose | A metabolite of Indole-3-butyric acid in plants. Uses: A metabolite of indole-3-butyric acid. Synonyms: 1-(1H-Indole-3-butanoate) β-D-Glucopyranose; 1-O-(Indole-3'-butanoyl)-β-D-Glucopyranose. CAS No. 147138-23-6. Molecular formula: C18H23NO7. Mole weight: 365.38. | |
| Indomethacin acyl glucuronide | a metabolite of Indomethacin. Synonyms: 1-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate] β-D-Glucopyranuronic Acid; Indomethacin Glucuronide. Grades: > 95%. CAS No. 75523-11-4. Molecular formula: C25H24ClNO10. Mole weight: 533.91. | |
| Indomethacin heptyl ester | Indomethacin heptyl ester is a potent, non-selective COX-2 inhibitor. Synonyms: 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, 1-heptyl ester. CAS No. 282728-47-6. Molecular formula: C26H30ClNO4. Mole weight: 456. | |
| Indotecan (LMP400) | Indotecan is a potent inhibitor of topoisomerase 1 (Top1) with IC50s of 300, 1200 and 560 nM for P388, HCT116 and MCF-7 cell lines, respectively. Synonyms: LMP-400; NSC-724998; 2,3-Dimethoxy-6-[3-(4-morpholinyl)propyl]-5H-[1,3]dioxolo[5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione; 5H-[1,3]Dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 2,3-dimethoxy-6-[3-(4-morpholinyl)propyl]-; 3-[(Morpholine)-1-propyl]-5,6-dihydro-2,3-dimethoxy-8,9-methylenedioxy-5,11-dioxo-11H-indeno[1,2-c]isoquinoline. Grades: ≥98%. CAS No. 915303-09-2. Molecular formula: C26H26N2O7. Mole weight: 478.49. | |
| Indusatumab | Indusatumab is a monoclonal antibody targeting Guanylate cyclase 2C (GUCY2C). Synonyms: 5F9 Monoclonal antibody. CAS No. 1497400-26-6. | |
| INDY | INDY is a DYRK1A/B inhibitor with IC50 values are 0.23 μM and 0.24 μM for DYRK1B and DYRK1A respectively. It impairs the self-renewal capacity of subventricular zone neural stem cells. Synonyms: (1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one. Grades: >98%. CAS No. 1169755-45-6. Molecular formula: C12H13NO2S. Mole weight: 235.3. | |
| INF 4E | INF 4E is an inhibitor of caspase-1 and NLRP3 ATPase activities. It inhibits nigericin or ATP induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells, and activates the Keap1-Nrf2 pathway. It acts by irreversibly trapping thiol nucleophiles and preventing both nigericin-triggered and ATP-pyroptosis of human THP-1 cells in a concentration- and time-dependent manner. It was used to study the electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. Synonyms: NLRP3-IN-9; NLRP3 IN 9; NLRP3IN9; INF-4E; INF 4E; INF4E; Ethyl 2[ (2-chlorophenyl) (hydroxy)methyl]acrylate. Grades: ≥98% by HPLC. CAS No. 88039-46-7. Molecular formula: C12H13ClO3. Mole weight: 240.68. | |
| Infliximab | Infliximab is a monoclonal antibody drug that is used for the treatment of rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. It binds to tumor necrosis factor alpha (TNF-α), which plays a role in the autoimmune reation. Infliximab may lead to fatal infections yet. Synonyms: Immunoglobulin G, anti-(human tumor necrosis factor) (human-mouse monoclonal cA2 heavy chain), disulfide with human-mouse monoclonal cA2 light chain, dimer; Avakine; Remicade; Remsima. Grades: 95%. CAS No. 170277-31-3. | |
| INH-13 | INH-13 is an Aurora Kinase inhibitor. Synonyms: INH 13; INH13; Benzamide, N-[5-[[7-[(2S)-2-hydroxy-3-(1-piperidinyl)propoxy]-6-methoxy-4-quinazolinyl]amino]-2-pyrimidinyl]-. Grades: 98%. CAS No. 1016971-82-6. Molecular formula: C28H31N7O4. Mole weight: 529.59. | |
| INH6 | INH6 is a potent Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. Synonyms: INH6; INH 6; INH-6; Hec1/Nek2 Mitotic Pathway Inhibitor II. Grades: >98%. CAS No. 1001753-24-7. Molecular formula: C19H18N2OS. Mole weight: 322.42. | |
| Inositol nicotinate | Inositol nicotinate, with vasodilatory effect, is used in the study of Peripheral arterial disease (PAD)[1]. Synonyms: Inositol niacinate; myo-Inositol hexanicotinate. CAS No. 6556-11-2. Molecular formula: C42H30N6O12. Mole weight: 810.72. | |
| INOTUZUMAB OZOGAMICIN | INOTUZUMAB OZOGAMICIN is an antibody-drug conjugate targeting CD22 for the treatment of adults with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL). Uses: The treatment of acute lymphoblastic leukemia (all). Synonyms: Besponsa. CAS No. 635715-01-4. Molecular formula: C73H96IN6O25S3. Mole weight: 1680.67. | |
| INT-777 | INT-777(S-EMCA) is a novel potent and selective TGR5 agonist with remarkable in vivo activity (EC50=0.82 uM). Synonyms: INT-777; INT 777; INT777; 6-EMCA; S-EMCA; ?HY-15677. Grades: >98%. CAS No. 1199796-29-6. Molecular formula: C27H46O5. Mole weight: 450.65. | |
| Iobenguane | Iobenguane I 131 is a guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. Uses: Enzyme inhibitors. Synonyms: 3-Iodobenzylguanidine, 131I-MIBG, Azedra, I-131 MIBG, Iobenguane (131I) , Iobenguane I 131, MIBG, MIBG-(131 I), Ultratrace iobenguane I131. Grades: >98%. CAS No. 77679-27-7. Molecular formula: C8H10IN3. Mole weight: 279.095. | |
| Iodipamide | Iodipamide is a water-soluble radiographic contrast agent for cholecystography and intravenous cholangiography. It is a tri-iodinated benzoate derivative and ionic dimeric contrast agent used in diagnostic imaging. It blocks x-rays and appears opaque on x-ray film, thus it enhances the visibility of the bile ducts and gallbladder during cholangiography and cholecystography procedures. Uses: Iodipamide is a radiographic contrast agent for cholecystography and intravenous cholangiography. it is used in diagnostic imaging. Synonyms: Biligrafin; Iodipamic acid; Bilignost; Bilignostum; 3,3'-(Adipoyldiimino)bis(2,4,6-triiodobenzoic acid). Grades: 98%. CAS No. 606-17-7. Molecular formula: C20H14I6N2O6. Mole weight: 1139.76. | |
| Ioflubenzamide I-131 | Ioflubenzamide I-131 is an iodine 131-radiolabeled small-molecule benzamide compound with potential antineoplastic activity. The benzamide moiety of ioflubenzamide I-131 binds to melanin, selectively delivering a cyotoxic dose of gamma and beta radiation to melanin-expressing tumor cells. Melanin pigments, polymer derivatives of the amino acid tyrosine, are over-expressed in approximately 40% of melanomas. Synonyms: BA-100; MIP-1145; 131-I-MIP-1145. CAS No. 864462-68-0. Molecular formula: C21H25F131IN3O3. Mole weight: 517.35. | |
| Ipexidine mesylate | Ipexidine mesylate is a bio-active chemical compound. Synonyms: Urea, N,N''-(1,4-Piperazinediylbis(3,1-propanediyliminocarbonimidoyl)bis(N'-hexyl-, dimethanesulfonate; CK-0569; Guanidino propyl piperazine. Grades: 98%. CAS No. 69017-90-9. Molecular formula: C28H62N10O8S2. Mole weight: 730.98. | |
| Ipilimumab | Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. Synonyms: BMS-734016; MDX-010; BMS 734016; MDX 010; BMS734016; MDX010. CAS No. 477202-00-9. Molecular formula: C6742H9972N1732O2004S40. | |
| IPN-60090 | IPN-60090 is a glutaminase inhibitor with potential anti-tumor and immunostimulatory activities. Grades: ≥98% by HPLC. CAS No. 1853164-83-6. Molecular formula: C24H27F3N8O3. Mole weight: 532.5. | |
| Ipratropium | Ipratropium is a synthetic anticholinergic agent. It is a muscarinic antagonist structurally related to atropine. It is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema. It is also used to treat the symptoms of chronic obstructive pulmonary disease and asthma.It is also used as an antiarrhythmic. Uses: Ipratropium is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema. it is also used to treat the symptoms of chronic obstructive pulmonary disease and asthma.it is also used as an antiarrhythmic. Synonyms: N-Isopropylatropine; (3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane; Apovent; Ipraxa; Rinatec. Grades: 98%. CAS No. 60205-81-4. Molecular formula: C20H30NO3. Mole weight: 332.46. | |
| Iproplatin | Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. Synonyms: CHIP; Code name: JM-9; JM 9; JM9. CAS No. 62928-11-4. Molecular formula: C6H22Cl2N2O2Pt. Mole weight: 420.24. | |
| IQ-1 | IQ-1, a cell-permeable tetrahydroisoquinolinylidene compound, disrupts Wnt signaling that enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Synonyms: 2-(4-Acetyl-phenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide. Grades: >98%. CAS No. 331001-62-8. Molecular formula: C21H22N4O2. Mole weight: 362.42. | |
| Irbesartan N2-Glucuronide | A metabolite of Irbesartan. Synonyms: 1-[5-[4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl][1,1'-biphenyl]-2-yl]-2H-tetrazol-2-yl]-1-deoxy-β-D-glucopyranuronic Acid. Grades: > 95%. CAS No. 160205-58-3. Molecular formula: C31H36N6O7. Mole weight: 604.65. | |
| IRC-083927 | IRC-083927 is novel and potent microtubule inhibitor with potential anticancer activity. IRC-083927 inhibits the tubulin polymerization by a binding to the colchicine site. IRC-083927 inhibits in vitro cell growth of human cancer cell lines in the low nanomolar range. More interesting, it remains highly active against cell lines resistant to microtubule-interacting agents (taxanes, Vinca alkaloids, or epothilones). Chronic oral treatment with IRC-083927 (5 mg/kg) inhibits the growth of two human tumor xenografts in nude mice (C33-A, human cervical cancer and MDA-MB-231, human hormone-independent breast cancer). Together, the antitumor effects induced by IRC-083927 on tumor models resistant to tubulin agents support further investigations to fully evaluate its potential for the treatment of advanced cancers, particularly those resistant to current clinically available drugs. Synonyms: IRC-083927; IRC 083927; IRC083927. Grades: 98%. CAS No. 955082-09-4. Molecular formula: C22H20ClFN4O4S. Mole weight: 490.93. | |
| IRC-274 | IRC-274 is a novel inhibitor of adrenocorticotropic hormone (ACTH) that can competitively bind to MC2 (IC50 = 3 nM). In HEK-293 cells, it suppressed the production of cAMP induced by ACTH in dose manner. Uses: Antitumor drug. Synonyms: IRC 274; IRC274. | |
| Iristectorigenin A 7-glucoside | Cas No. 94396-09-5. | |
| IRL-1620 | IRL-1620, also known as SPI-1620, is an endothelin B receptor agonist. SPI-1620 is a highly selective peptide agonist of the endothelin-B receptor. Endothelin B receptor agonist SPI-1620 binds to endothelin-B receptors on endothelial cells in tumor blood vessels, which, unlike the angioarchitecture of normal blood vessels, are relatively devoid of smooth muscle. This agent may induce a transient, selective increase in blood flow to a tumor, which may result in an increase in the delivery of anticancer agents to the tumor and, so, an increase in anticancer agent efficacy. Synonyms: SPI-1620; IRL1620; IRL 1620. CAS No. 142569-99-1. Molecular formula: C86H117N17O27. Mole weight: 1820.97. | |
| Irosustat | Irosustat, also known as STX64, BN83495 and 667 coumate, is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50= 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity. Synonyms: BN83495; BN-83495; BN 83495; STX 64; STX-64; STX64; 667-Coumate; Sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester. CAS No. 288628-05-7. Molecular formula: C14H15NO5S. Mole weight: 309.34. | |
| Isatoribine | Isatoribine is a novel guanosine analogue showing immunostimulatory activity both in vivo and in vitro. This compound acts on different components of the immune system including B cells, natural killer (NK) cells and antigen-presenting cells (APC). Synonyms: ANA245; ANA 245; ANA-245; Immusine; Isatoribine hydrate; Isatoribine monohydrate; D04619; D 04619; D-04619; 7-thia-8-oxoguanosine. CAS No. 198832-38-1. Molecular formula: C10H14N4O7S. Mole weight: 334.30. | |
| Isatuximab | Isatuximab is an anti-CD38 monoclonal antibody that has been approved for use in the treatment of adults with multiple myeloma. Synonyms: SAR650984; hu38SB19. CAS No. 1461640-62-9. | |
| ISC-4 | ISC-4 is an Akt inhibitor, which activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model. Synonyms: ISC-4; ISC 4; ISC4. CAS No. 1072807-15-8. Molecular formula: C11H13NSe. Mole weight: 238.20. | |
| (-)-isolariciresinol-2a-O-b-D-xylopyranoside | (-)-Isolariciresinol-2a-O-b-D-xylopyranoside, a lignan compound with a natural origin from different medicinal plants, like Linum Usitatissimum and Lonicera japonica, has been demonstrated to exhibit strong antioxidant and anticancer properties. Notably, it has been recognized as a potential therapeutic agent for breast cancer and diabetes treatment. This compound, owing to its diverse beneficial effects, holds a significant position in the field of natural product-based pharmaceutical research. | |
| Isomannide | Isomannide (CAS# 641-74-7) is a reagent used in the synthesis of new isomannide-based peptidomimetic as human tissue kallikrein 1 inhibitor using Ugi multicomponent reaction. It also functions as a chiral ligand for stereoselective synthesis. Synonyms: D-Mannitol, 1,4:3,6-dianhydro-; 1,4:3,6-Dianhydro-D-mannitol; Mannitol, 1,4:3,6-dianhydro-, D-; (+)-Isomannide; (3R,3aR,6R,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol; 1,4:3,6-Dianhydromannitol; D-Isomannide; Dianhydromannitol; NSC 270938. Grades: ≥95%. CAS No. 641-74-7. Molecular formula: C6H10O4. Mole weight: 146.14. | |
| isopropyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopiranoside | Isopropyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopiranoside, a biochemical compound utilized in the synthesis of oligosaccharides, plays an instrumental role in the chemical industry. Acting as a protective knight covering the thiol functionality, it effectively prepares lactose analogs. Additionally, its potential as an agent in the treatment of bacterial and viral infections merits further study. Synonyms: [(3S,4S,6S)-3,4,5-triacetyloxy-6-propan-2-ylsulfanyloxan-2-yl]methyl acetate; β-D-Galactopyranoside, 1-methylethyl 1-thio-, tetraacetate. Grades: 98%. CAS No. 55692-87-0. Molecular formula: C17H26O9S. Mole weight: 406.448. | |
| Isopropyl 2,3,4,6-tetra-O-acetyl-b-D-thiogalactopyranoside | Isopropyl 2,3,4,6-tetra-O-acetyl-b-D-thiogalactopyranoside is a renowned biochemical compound pervasive, occuping a paramount position for unraveling the intricate mechanisms underpinning drug metabolism. This compound thrives in the expanse of drug discovery and development, meticulously engineered to study an array of afflictions encompassing cancer, diabetes and infectious diseases. | |
| Isopropyl 2,3,4,6-tetra-O-acetyl-b-D-thioglucopyranoside | Isopropyl 2,3,4,6-tetra-O-acetyl-beta-D-thioglucopyranoside is an indispensable compound remarkably proficient in facilitating the amalgamation of glycoconjugates and glycosides. It serves as a remarkable tool for investigating intricate carbohydrate-protein interactions. Synonyms: Isopropyl 2,3,4,6-tetra-O-acetyl-b-D-thioglucopyranoside; 55692-84-7; BP-22503. CAS No. 55692-84-7. Molecular formula: C17H26O9S. Mole weight: 406.45. | |
| Isopropyl 2-acetamido-2-deoxy-α-D-glucopyranoside | Isopropyl 2-acetamido-2-deoxy-α-D-glucopyranoside is a highly significant compound in the biomedical industry, exhibiting remarkable versatility. Employed extensively as a compound in diverse biochemical and pharmaceutical investigations, it assumes a pivotal function in the synthesis of glycosides, glycoproteins and antibiotics. CAS No. 19124-40-4. Molecular formula: C11H21NO6. Mole weight: 263.29. | |
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