BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| GSK299423 | GSK299423 is an antibiotic agent and it seems potentially effective in treating patients infected with bacteria expressing the New Delhi metallo-beta-lactamase. GSK299423 is a Type II bacterial DNA topoisomerase inhibitor under the development of GlaxoSmithKline. Early research for the treatment of Gram-negative infections and Nosocomial infections was on-going in USA. Uses: Gram-negative infections; nosocomial infections. Synonyms: GSK299423; GSK 299423; GSK-299423; 4-(2-(4-(([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile. Grades: 98%. CAS No. 1352149-24-6. Molecular formula: C25H27N5O2S. Mole weight: 461.58. |  |
| GSK429286A | GSK429286A is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. Uses: Reprogramming, self-renewal. Synonyms: GSK 429286A; GSK-429286A. Grades: 0.98. CAS No. 864082-47-3. Molecular formula: C21H16F4N4O2. Mole weight: 432.37. | |
| GSK-5498A | GSK-5498A, a CRAC channel blocker, has been found to have effect in restraining pro-inflammatory cytokine. IC50: 1 uM. Uses: Gsk-5498a is a crac channel blocker that has been found to have effect in restraining pro-inflammatory cytokine. Synonyms: GSK-5498A; GSK5498A; GSK 5498A; 2,6-Difluoro-N-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide. Grades: 97%. CAS No. 1253186-49-0. Molecular formula: C18H11F6N3O. Mole weight: 399.29. | |
| GSK5959 | GSK-5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 value of 80 nM. It exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. It is used at 10 μM final concentration in various in vitro assays. It disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3 in vitro. Uses: Gsk-5959 disrupts chromatin binding of brpf1 in a cellular assay. Synonyms: N-(1,3-dimethyl-2-oxo-6-piperidin-1-ylbenzimidazol-5-yl)-2-methoxybenzamide;GSK-5959; GSK 5959; GSK5959. Grades: >98%. CAS No. 901245-65-6. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
| GSK621 | GSK621 is an activator of AMP-activated protein kinase (AMPK). GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation. Synonyms: GSK-621; GSK 621. Grades: 98%. CAS No. 1346607-05-3. Molecular formula: C26H20ClN3O5. Mole weight: 489.91. | |
| GSK-7186 | GSK-7186 is a novel inhibitor of HIV integrase that is used for the treatment of Non-cross-resistant HIV infection. Uses: The treatment of non-cross-resistant hiv infection. Synonyms: GSK7186; GSK 7186. | |
| GSK-923295 | GSK-923295 is a novel antimitotic inhibitor of centromere-associated protein E (CENP-E) with potential anticancer activity. GSK-923295 demonstrated significant antitumor activity against solid tumor models, inducing CRs in Ewing sarcoma, rhabdoid, and rhabdomyosarcoma xenografts. Clinical study showed that GSK-923295 had dose-proportional pharmacokinetics and a low number of grade 3 or 4 adverse events. The observed incidence of myelosuppression and neuropathy was low. Further investigations may provide a more complete understanding of the potential for GSK-923295 as an antiproliferative agent. Synonyms: GSK923295; GSK 923295; GSK-923295; GSK-923295A; GSK923295A; GSK 923295A. Grades: 98%. CAS No. 1088965-37-0. Molecular formula: C32H38ClN5O4. Mole weight: 592.14. | |
| GSK 9311 hydrochloride | GSK9311 is a potent inhibitor of the BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively. GSK 9311 is a negative control for the SGC epigenetic probe GSK6853. Synonyms: N-[2,3-Dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxybenzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1923851-49-3. Molecular formula: C24H31N5O3·HCl. Mole weight: 474. | |
| GT 949 | GT 949 is a potent and selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM) which exhibits no significant effect on DAT, SERT and NET or NMDA receptors. Synonyms: 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one. Grades: ≥98%. CAS No. 460330-27-2. Molecular formula: C30H37N7O2. Mole weight: 527.66. | |
| GTP-14564 | GTP-14564 is a specific kinase inhibitor for ITD-FLT3. GTP-14564 inhibited the growth of interleukin-3-independent Ba/F3 expressing ITD-FLT3 at 1 microM, whereas a 30-fold higher concentration of GTP-14564 was required to inhibit FLT3 ligand-dependent growth of Ba/F3 expressing wild type FLT3 (wt-FLT3). Synonyms: GTP 14564; GTP14564; 1-Phenyl-3-H-8-oxa-2,3-diaza-cyclopenta[a]inden. CAS No. 34823-86-4. Molecular formula: C15H10N2O. Mole weight: 234.25. | |
| GUB09-145 | GUB09-145 is a dual analog of the insulinotropic hormone GLP-1 and the intestinotropic hormone GLP-2. It can reduce body weight and improve glucose homeostasis as a Roux-en-Y gastric bypass (RYGB) mimetic, which is effective treatment modalities for obesity. GUB09-145 exhibits a long-acting activity and the potential to cure obesity and diabetes. Uses: The potential treatment of obesity and diabetes. Synonyms: GUB09 145; GUB09145. | |
| Gusperimus | Gusperimus is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. Uses: Immunosuppressive agents. Synonyms: deoxyspergualin; Deoxyspergualin Hydrochloride; Gusperimus Trihydrochloride; BMS-181173; BMS181173; BMS 181173; BMY-42215-1; BMY 42215 1; NKT-01; NKT 01; NKT01. CAS No. 104317-84-2. Molecular formula: C17H37N7O3. Mole weight: 387.52. | |
| GVK-904 | GVK-904 is an inhibitor of Trk-A with high selectivity for wild-type cancers. GVK-904 is a non-ATP-competitive inhibitor. It can be used to treat cancers induced by Trk-A. Uses: Antitumor drug. Synonyms: GVK 904; GVK904. | |
| GW 406381 | GW 406381 is a selective cyclooxygenase-2 (COX-2) inhibitor that is effective in the treatment of inflammatory pain, neurodynia, Trauma and others. Uses: The treatment of inflammatory pain. Synonyms: GW-406381; GW 406381; GW406381. 2-(4-ethoxyphenyl)-3-(4-methylsulfonylphenyl)pyrazolo[1,5-b]pyridazine. Grades: 99%. CAS No. 221148-46-5. Molecular formula: C21H19N3O3S. Mole weight: 393.46. | |
| GW788388 | GW788388 is a selective inhibitor of TGF-beta type I receptor (TGF-βR1/ALK5; IC50=18 nM) with a much improved pharmacokinetic profile compared with SB431542. It inhibited both the TGF-beta type I and type II receptor kinase activities, but not that of the related bone morphogenic protein type II receptor. Synonyms: GW-788388; N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide. Grades: >98%. CAS No. 452342-67-5. Molecular formula: C25H23N5O2. Mole weight: 425.492. | |
| GW791343 | GW791343, as a P2X7 receptor antagonist, was a negative allosteric modulator of the human P2X(7) receptor but at the rat P2X(7) receptor its predominant effect was positive allosteric modulation. Uses: P2x7 receptor antagonist. Synonyms: GW-791343; GW791343. Grades: ≥98%. CAS No. 309712-73-0. Molecular formula: C20H24F2N4O. Mole weight: 374.4. | |
| GW841819X | GW841819X, a benzodiazepin derivative, has been found to be a BET bromodomains inhibitor that could be probably significant in the study of myeloma and leukemia at some extent. Synonyms: KB-75882; KB 75882; KB75882; benzyl (1-methyl-6-phenyl-4hbenzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate. Grades: 98%. CAS No. 146135-18-4. Molecular formula: C25H21N5O2. Mole weight: 423.48. | |
| GXpep-3 | GXpep-3 is a novel polypeptide inhibitor of phospholipid hydroperoxidase glutathione peroxidase (GPX4). Currently GPX4 is found to be a target which selectively induces iron-dependent cell death (ferroptosis) in cancer cells that express mutant Ras. GXpep-3 is promisingly developed to be a antitumor drug. Uses: Antitumor. Synonyms: GXpep 3; GXpep3. | |
| gypsogenin-3-O-glucuronide | Methyl gypsogenin 3-O-beta-D-glucuronopyranoside can be isolated from the seeds of Momordica cochinchinensis. Synonyms: Methyl(gypsogenin-3-O-β-D-gluco pyranoside)uronate; gypsogenin-3-O-β-D-glucopyranosideuronate; (3beta,4alpha)-17-Carboxy-23-oxo-28-norolean-12-en-3-yl-beta-D-glucopyranosiduronic acid 6-methyl ester; Methyl gypsogenin 3-O-beta-D-glucuronopyranoside. Grades: >98%. CAS No. 96553-02-5. Molecular formula: C37H56O10. Mole weight: 660.83. | |
| GZD824 Dimesylate | GZD824 Dimesylate is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. Synonyms: Olverembatinib dimesylate; HQP1351 dimesylate; GZD 824 Dimesylate; GZD-824 Dimesylate; 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide dimethanesulfonate; Benzamide, 4-methyl-N-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1H-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-, methanesulfonate (1:2). Grades: ≥99%. CAS No. 1421783-64-3. Molecular formula: C29H27F3N6O.2CH4O3S. Mole weight: 724.77. | |
| H 89 | Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM. Synonyms: Protein kinase inhibitor H-89; H89; H 89. Grades: >98%. CAS No. 127243-85-0. Molecular formula: C20H20BrN3O2S. Mole weight: 446.36. | |
| Ha-15 | HA-15 is a compound that targets BiP/GRP78/HSPA5 with an antitumor activity on all melanoma cells. Uses: Ha-15 is a compound that targets bip/grp78/hspa5 with an antitumor activity. Synonyms: HA15; HA 15; N-(4-(3-((5-(dimethylamino)naphthalene)-1-sulfonamido)phenyl)thiazol-2-yl)acetamide. Grades: ≥98%. CAS No. 1609402-14-3. Molecular formula: C23H22N4O3S2. Mole weight: 466.574. | |
| HAC-Y6 | HAC-Y6 is a novel and potent microtubule inhibitor. HAC-Y60 exhibited potent antitumor activity against human hepatocellular carcinoma (HCC) cells in vitro. Synonyms: HACY6; HAC Y6; 6-acetyl-9-(3,4,5-trimethoxybenzyl)-9h-pyrido [2,3-b]indole. Grades: 98%. CAS No. 1331959-78-4. Molecular formula: C23H22N2O4. Mole weight: 390.43. | |
| Haloperidol β-D-Glucuronide | Haloperidol β-D-Glucuronide is a metabolite of Haloperidol. Synonyms: 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl β-D-Glucopyranosiduronic Acid; Haloperidol Glucuronide. Grades: > 95%. CAS No. 100442-88-4. Molecular formula: C27H31ClFNO8. Mole weight: 551.99. | |
| Harmol | Harmol is an apoptosis inducer. Synonyms: 1-methyl-9H-pyrido[3,4-b]indol-7-ol; 1-Methyl-9H-beta-carbolin-7-ol. CAS No. 487-03-6. Molecular formula: C12H10N2O. Mole weight: 198.225. | |
| Harmol hydrochloride | Harmol is an apoptosis inducer. Synonyms: Harmol HCl; 1-methyl-2,9-dihydropyrido[3,4-b]indol-7-one hydrochloride. CAS No. 40580-83-4. Molecular formula: C12H11ClN2O. Mole weight: 234.683. | |
| HE-3235 | HE3235 is an orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2. Synonyms: HE 3235; HE3235; Apoptone; (17R)-5alpha-Pregnane-20-yne-3alpha,17-diol. CAS No. 183387-50-0. Molecular formula: C21H32O2. Mole weight: 316.48. | |
| Heclin | Heclin is an HECT E3 ubiquitin ligase inhibitor. It also inhibits Nedd4, Smurf2 and WWP1 (IC50 = 6.3, 6.8 and 6.9 μM, respectively). Uses: Enzyme inhibitors. Synonyms: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide. Grades: ≥98% by HPLC. CAS No. 890605-54-6. Molecular formula: C17H17NO3. Mole weight: 283.32. | |
| Helicid | Helicid, which could be extracted from the roots of Helicia erratica Hook. f, could bind to hydrophobic pocket of human serum albumin with hydrophobic and hydrogen bond force. The binding site of Helicid in HSA was ascertained. Uses: Antidepressant. Synonyms: 4-b-D-Allopyranosyloxy)benzaldehyde. Grades: >98%. CAS No. 80154-34-3. Molecular formula: C13H16O7. Mole weight: 284.26. | |
| Henatinib | Henatinib inhibits vascular endothelial growth factor receptor type 2 (VEGFR2), a tyrosine kinase receptor upregulated in many tumor cells that plays a key role in angiogenesis. This may result in an inhibition of angiogenesis and eventually tumor cell proliferation. Henatinib, structurally similar to sunitinib, also inhibits, though to a lesser extent, mast/stem cell growth factor receptor (c-Kit) and, platelet-derived growth factor receptor (PDGFR) alpha and beta. Synonyms: (R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one. CAS No. 1239269-51-2. Molecular formula: C25H29FN4O4. Mole weight: 468.53. | |
| Hepsulfam | Hepsulfam is a bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents. Hepsulfam forms covalent linkages with nucleophilic centers in DNA, resulting in depurination, base miscoding, strand scission, DNA-DNA and DNA-protein cross-linking, and cytotoxicity. Check for active clinical trials or closed clinical trials using this agent. Synonyms: 1,7-Heptanediol disulfamate; Sulfamic acid, 1,7-heptanediyl ester; NSC-329680. CAS No. 96892-57-8. Molecular formula: C7H18N2O6S2. Mole weight: 290.35. | |
| Heptaplatin | Eptaplatin is a platinum-based coordination compound with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines. Synonyms: Heptaplatin, Sunpla; HTP; NSC-644591, NSC 644591;NSC644591; NSC-D-644591; NSC D 644591; SKI-2053R; SKI 2053R. Grades: >98%. CAS No. 146665-77-2. Molecular formula: C11H20N2O6Pt. Mole weight: 471.36. | |
| Hesperetin 3-O-b-D-glucuronide | Hesperetin 3-O-b-D-glucuronide is an extraordinary and essential molecule possessing remarkable anti-inflammatory and antioxidant attributes. Synonyms: 5-(3,4-Dihydro-5,7-dihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2-methoxyphenyl b-D-glucopyranosiduronic acid. CAS No. 1237479-05-8. Molecular formula: C22H22O12. Mole weight: 478.40. | |
| Hesperetin 7,3-O-b-D-glucuronide | Product Name: Hesperetin 7,3-O-b-D-glucuronide is a compound distilled from the wholesome essence of citrus fruits. Specifically celebrated for its exceptional antioxidant attributes, it expeditiously studys oxidative stress-associated afflictions, including the intricate spectra of cardiovascular anomalies and neurodegeneration. Molecular formula: C28H30O18. Mole weight: 654.53. | |
| Hesperetin 7-O-b-D-glucuronide | Hesperetin 7-O-b-D-glucuronide is a well-known flavonoid glycoside with anti-inflammatory and antioxidant attributes. Consequently, this compound plays a pivotal role in the formulation of pharmacotherapies specifically designed to study inflammation-linked ailments like cancer, cardiovascular disorders and neurodegenerative diseases. Synonyms: 3,4-Dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-2H-1-benzopyran-7-yl b-D-glucopyranosiduronic acid. CAS No. 1237479-09-2. Molecular formula: C22H22O12. Mole weight: 478.40. | |
| HET0016 | 20-HETE is a selective inhibitor of 20-HETE synthesis, a second mitogenic messenger of angiogenesis inducing growth factors. It inhibits CYP4A to block the synthesis of 20-HETE, and suppresses the angiogenic responses to several growth factors. Synonyms: HET 0016; HET0016; N-hydroxy-N'-(4-n-butyl-2-methylphenyl)Formamidine. Grades: ≥98%. CAS No. 339068-25-6. Molecular formula: C12H18N2O. Mole weight: 206.3. | |
| Hexadecyl-D-xylopyranoside | Hexadecyl-D-xylopyranoside is a quintessential biomedical compound, reigning supreme as a non-ionic detergent paragon in the vibrant realm of biotechnology and pharmaceutical research. Its unrivaled prowess lies in its profound aptitude for solubilizing and stabilizing the elusive membrane proteins. Synonyms: (3R,4S,5R)-2-hexadecoxyoxane-3,4,5-triol. CAS No. 115211-19-3. Molecular formula: C21H42O5. Mole weight: 374.56. | |
| Hexa-O-benzoyl 10-Demethyl Colchicoside | Hexa-O-benzoyl 10-Demethyl Colchicoside is an intermediate in synthesizing Isothiocolcicoside, which is an impurity of Thiocolchicoside, a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Synonyms: (2S,3R,4S,5R,6R)-2-(((S)-10-(Benzoyloxy)-1,2-dimethoxy-9-oxo-7-(3-oxo-3-phenylpropanamido)-5,6,7,9-tetrahydrobenzo[a]heptalen-3-yl)oxy)-6-((benzoyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl Tribenzoate. Molecular formula: C68H55NO17. Mole weight: 1158.16. | |
| Hexestrol | Hexestrol is a nonsteroidal synthetic estrogen, with Kis of 0.06 and 0.06 nM, and EC50s of 0.07 and 0.175 nM for ERα and ERβ, respectively. It can be used to study diseases caused by estrogen deficiency and to increase the weight of cattle. Uses: Antineoplastic agents, hormonal; estrogens, non-steroidal. Synonyms: rel-4,4'-[(1R,2S)-1,2-Diethyl-1,2-ethanediyl]bisphenol; meso-3,4-Di(p-hydroxyphenyl)-n-hexane; Cycloestrol; Erythrohexestrol; Estrifar; Hexron; Hormoestrol; Mesohexestrol; NSC 9894; Sinestrol; Synestrol; Synoestrol; Synthovo; Syntrogene; Estronal; meso-Hexestrol. Grades: >98%. CAS No. 84-16-2. Molecular formula: C18H22O2. Mole weight: 270.37. | |
| HhAntag | HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway. Synonyms: HhAntag; Hh-Antag; Hh Antag; Benzamide, N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxy-. Grades: >98%. CAS No. 496794-70-8. Molecular formula: C24H23ClN4O3. Mole weight: 450.92. | |
| Hibifolin | Hibifolin is a biomedical compound, aiding in research of inflammation-induced afflictions, including the pervasive rheumatoid arthritand pernicious dermatitis. Synonyms: [2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4-oxo-4H-1-benzopyran-8-yl]b-D-glucopyranosiduronic acid. CAS No. 55366-56-8. Molecular formula: C21H18O14. Mole weight: 494.36. | |
| (±)-HIP-A | (±)-HIP-A is a potent and non-competitive excitatory amino acid transporter (EAAT) blocker. (±)-HIP-A displays no affinity for NMDA and metabotropic glutamate receptors, and weak affinity for AMPA and kainate receptors (IC50 = 43 and 8 μM, respectively). (±)-HIP-A inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). Synonyms: (±)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 227619-64-9. Molecular formula: C6H8N2O4. Mole weight: 172.14. | |
| (±)-HIP-B | (±)-HIP-B is a potent and non-competitive excitatory amino acid transporter (EAAT) blocker. (±)-HIP-B displays no affinity for NMDA and metabotropic glutamate receptors, and weak affinity for AMPA and kainate receptors (IC50 = 35 and 45 μM, respectively). (±)-HIP-B inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 μM) rather than [3H]L-glutamate uptake (IC50 = 16.9 μM). Synonyms: (±)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 227619-65-0. Molecular formula: C6H8N2O4. Mole weight: 172.14. | |
| Histamine dihydrochloride | Histamine dihydrochloride is a histamine salt used to prevent relapse in patients with acute myeloid leukemia (AML). It is also used as an active ingredient in topical analgesia for temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains and strains. Uses: Present in most mammalian tissues; primarily stored in mast cells and basophils. exhibits multiple biological effects through at least 3 specific receptors. induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter. histamine has been identified as a bedbug pheromone. Synonyms: 1H-Imidazole-4-ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethanamine Dihydrochloride; 2-(1H-Imidazol-4-yl)ethylamine Dihydrochloride; 4-(2-Aminoethyl)imidazole Dihydrochloride; Ceplene; Peremin; 2-(1H-imidazol-4-yl)ethan-1-amine dihydrochloride. Grades: >98%. CAS No. 56-92-8. Molecular formula: C5H9N3.2HCl. Mole weight: 184.07. | |
| Histamine Phosphate | Histamine phosphate is a potent histamine receptor agonist and vasodilator. It acts directly on the blood vessels to dilate arteries and capillaries mediated by both H1- and H2-receptors. Synonyms: Histamine diphosphate; Histamine acid phosphate; Histamine biphosphate; 2-(1H-imidazol-4-yl)ethanamine bis(phosphate); 1H-Imidazole-4-ethanamine, phosphate (1:2); Histamine dihydrogen phosphate; 4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate); 4-(2-Aminoethyl)imidazole di-acid phosphate; 2-(1H-Imidazol-4-yl)ethanamine phosphate (1:2). Grades: ≥98%. CAS No. 51-74-1. Molecular formula: C5H9N.2H3O4P. Mole weight: 307.14. | |
| Histone H3 (1-34) | Histone H3 (1-34) is a histone peptide that acts as a substrate for methyltransferase/demethylase enzymes. Synonyms: Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly. Molecular formula: C144H260N54O44. Mole weight: 3451.98. | |
| HJC-0123 | HJC-0123 is a potent and selective STT 3 inhibitor. HJC0123 has demonstrated to inhibit STAT3 promoter activity, downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy. Synonyms: HJC 0123; HJC0123; 2-Phenyl-quinoline-4-carboxylic acid (1,1-dioxo-1H-1lambda6-benzo[b]thiophen-6-yl)-amide. Grades: 98%. CAS No. 1430420-02-2. Molecular formula: C24H16N2O3S. Mole weight: 412.46. | |
| HJC0350 | HJC0350 is a potent and Epac2-specific inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1. Synonyms: HJC 0350; HJC-0350; 1-(mesitylsulfonyl)-2,4-dimethyl-1H-pyrrole. Grades: >98%. CAS No. 885434-70-8. Molecular formula: C15H19NO2S. Mole weight: 277.38. | |
| HLCL61 | HLCL61 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor. It is used for treatment of acute myeloid leukemia. It resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in acute myeloid leukemia cells. Uses: Hlcl61 is used for treatment of acute myeloid leukemia. Synonyms: HLCL-61; HLCL 61; 9-Ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine. Grades: 98%. CAS No. 586395-74-6. Molecular formula: C23H24N2O. Mole weight: 344.19. | |
| HLI 373 | HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53 and activates p53-dependent transcription. HLI 373 has a therapeutic effect in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS. Synonyms: HLI373; HLI-373; HLI 373; NSC-373989; NSC 373989; NSC373989. 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride. Grades: ≥99% by HPLC. CAS No. 502137-98-6. Molecular formula: C18H23N5O2.2HCl. Mole weight: 414.33. | |
| HLM006474 | HLM006474 is an E2F transcription factor inhibitor that suppresses binding of DNA. It can promote cell differentiation of human pluripotent stem cells (hPSCs). Synonyms: HLM-006474; 7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol. Grades: >98%. CAS No. 353519-63-8. Molecular formula: C25H25N3O2. Mole weight: 399.48. | |
| HM30181 | HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). HM30181 is currently under Phase I HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitax...the dose range evaluated, with the exception of the repeated administration of 360 mg, for which gastrointestinal disorders were frequently reported. The systemic exposure of HM30181 was relatively low, and dose proportional properties of HM30181 were not observed. Synonyms: 4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-; N-[2-[2-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide; Encequidar; HM 30181; HM-30181. Grades: 98%. CAS No. 849675-66-7. Molecular formula: C38H36N6O7. Mole weight: 688.74. | |
| HMN-176 | HMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia. Synonyms: HMN 176; HMN176; (E) -4- (2- (2- (N- ( (p-Methoxyphenyl) sulfonyl) amino) phenyl) ethenyl) pyridine 1-oxide. CAS No. 173529-10-7. Molecular formula: C20H18N2O4S. Mole weight: 382.43. | |
| HO-3867 | HO-3867 is a selective and potent STAT3 inhibitor that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 exhibited minimal toxicity toward noncancerous cells and tissues but induced apoptosis in ovarian cancer cells. Synonyms: HO 3867; EX-A2319; (3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]piperidin-4-one. Grades: >98%. CAS No. 1172133-28-6. Molecular formula: C28H30F2N2O2. Mole weight: 464.557. | |
| Homo Egonol β-D-Glucoside | A nor-Lignan from Styrax ferrugineus with antibacterial and antifungal activity. Uses: A nor-lignan from styrax ferrugineus with antibacterial and antifungal activity. Synonyms: 3-[2-(3,4-Dimethoxyphenyl)-7-methoxy-5-benzofuranyl]propyl β-D-Glucopyranoside. CAS No. 325791-19-3. Molecular formula: C26H32O10. Mole weight: 504.53. | |
| HPOB | HPOB is a potent, selective HDAC6 inhibitor with IC50 of 56 nM, >30-fold selectivity over other HDACs. Synonyms: 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenylbenzeneacetamide. Grades: >98%. CAS No. 1429651-50-2. Molecular formula: C17H18N2O4. Mole weight: 314.34. | |
| HS 38 | HS 38 is an ATP-competitive inhibitor of DAPK (IC50 = 200 nM) and ZIPK (Kd = 280 nM). It also inhibits PIM3 kinase (IC50 = 200 nM) with no significant effect on Src or Abl kinases. HS 38 regulates programmed cell death and phosphorylation of non-muscle and smooth muscle myosin. Synonyms: HS 38; HS38; HS-38; 2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide. Grades: ≥98% by HPLC. CAS No. 1030203-81-6. Molecular formula: C14H12CIN5O2S. Mole weight: 349.8. | |
| HTL-001 | HTL-001 is a novel inhibitor of HOX/PBX binding. In mouse models, it inhibited the growth of prostate and breast tumor. Besides, HTL-001 can significantly increase the expression of cFos and DUSP1, which are targets of HXR9. Uses: Anti-prostate and breast tumor. Synonyms: HTL-001; HTL001. | |
| H-Type 2-APE-HSA | | |
| H Type II-APD-BSA | | |
| Hyacinthacine A2 | Hyacinthacine A2 is a remarkable antifungal compound extracted from Hyacinthaceae plants, aiding in studying a myriad of fungal infections, encompassing candidiasand aspergillosis. Molecular formula: C8H15NO3. Mole weight: 173.21. | |
| Hyacinthacine B3 | Hyacinthacine B3 is a potent compound used to study bacterial infections exhibiting antimicrobial activity against a variety of pathogens, including multidrug-resistant strains. Synonyms: Hyacinthacine B3; CHEMBL524631; BDBM50278912; (1S,2R,3R,5R,7R,8R)-3-(hydroxymethyl)-5-methyl-2,3,5,6,7,8-hexahydro-1H-pyrrolizine-1,2,7-triol. Molecular formula: C9H17NO4. Mole weight: 203.24. | |
| Hycanthone | Hycanthone is the active metabolite of the anthelmintic prodrug Lucanthone, which is used in the treatment of schistosomiasis. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a KD of 10 nM. Synonyms: 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one; 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)thioxanthen-9-one; Hycanthon; NCI 142982; NSC 134434; NSC 142982; Win 24933. CAS No. 3105-97-3. Molecular formula: C20H24N2O2S. Mole weight: 356.48. | |
| Hydromorphone-3-D-glucuronide-D3 | | |
| (-)-Hydroxycitric acid | (-)-Hydroxycitrate is a potent competitive inhibitor of ATP citrate lyase, which inhibits fatty acid synthesis, lipogenesis, food intake and induced weight loss. Synonyms: Garcinia acid. Grades: 95%. CAS No. 27750-10-3. Molecular formula: C6H8O8. Mole weight: 208.12. | |
| Hydroxy Pioglitazone (M-IV) ß-D-Glucuronide | An impurity of Pioglitazone which a thiazolidinedione compound with antiinflammatory and antiarteriosclerotic effects. Synonyms: 1-[6-[2-[4-[(2,4-Dioxo-5-thiazolidinyl)methyl]phenoxy]ethyl]-3-pyridinyl]ethyl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 625853-76-1. Molecular formula: C25H28N2O10S. Mole weight: 548.56. | |
| Hyodeoxycholic acid (HDCA) | Hyodeoxycholic acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria. It is a TGR5 (GPCR19) agonist, with an EC50 of 31.6 μM in CHO cells. Synonyms: Iodeoxycholic acid; 7-Deoxyhyocholic acid; 3α,6α-Dihydroxy-5β-cholan-24-oic acid; 5β-cholan-24-oic acid-3α,6α-Diol; α-Hyodeoxycholic acid; 3α,6α-Dihydroxy-5β-cholanic acid. Grades: >98%. CAS No. 83-49-8. Molecular formula: C24H40O4. Mole weight: 392.57. | |
| Hypothemycin | Hypothemycin, a resorcylic acid lactone antibiotic, was identified as active in a screen for inhibitors of T cell activation. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone. This inhibition was partially reversed by exogenous IL-2 indicating that it is not due to non-specific toxicity. Hypothemycin potently suppressed the production of IL-2 (IC50: 9 nM) but affected IL-2-induced proliferation to a lesser extent (IC50: 194 nM). Hypothemycin also inhibited IL-6, IL-10, IFN-gamma and TNF-alpha production. By contrast, it markedly enhanced the production of IL-4, IL-5 and IL-13. These effects were seen both at the mRNA and protein secretion levels. Analysis of the effect of hypothemycin on CD69 induction suggested that it disrupts calcineurin-independent rather than calcineurin-dependent signaling. Furthermore, hypothemycin was able to inhibit the phosphorylation of ERK1/2 induced by PMA treatment of T cells. Therefore, hypothemycin represents an inhibitor of T cell activation with a novel mode of action and unique modulatory activity on cytokine production. Synonyms: Hypothemycin. CAS No. 76958-67-3. Molecular formula: C19H22O8. Mole weight: 378.38. | |
| IACS-9571 | IACS-9571, a benzoimidazol derivative, has been found to be a TRIM24 and BRPF1 inhibitor and could be probably significant in anticancer studies. Synonyms: N-(6-(3-(4-(dimethylamino)butoxy)-5-propoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-3,4-dimethoxybenzenesulfonamide; IACS-9571; IACS 9571; IACS9571; IACS 009571-001-4. Grades: 98%. CAS No. 1800477-30-8. Molecular formula: C32H42N4O8S. Mole weight: 642.77. | |
| IASOtoc | |
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