BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| GBR 12783 dihydrochloride | GBR 12783 dihydrochloride is a potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM). Synonyms: GBR 12783 dihydrochloride; GBR12783 dihydrochloride; GBR-12783 dihydrochloride; 1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 67469-75-4. Molecular formula: C28H32N2O.2HCl. Mole weight: 485.5. |  |
| GBR-12935 | GBR 12935 is a piperazine derivative and a potent and selective inhibitor of dopamine uptake with IC50 value of 3.7nM. It is found to have multiple binding sites in rat and human brains. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. It(1-9 nM) dose-dependently inhibited active uptake of [3H]dopamine in homogenates of the nucleus accumbens and could inhibit DA uptake with IC50 value of 3.7nM in vitro. It elevated locomotion to a greater extent in C57BL/6J mice at the maximally active dose of 10 mg/kg in vivo. It shows a Kd value of 1.08nM in dopamine transporter transfected COS-7 cells. It is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain. Uses: Gbr 12935 inhibits da uptake with ic50 value of 3.7nm in vitro. it elevated locomotion to a greater extent in c57bl/6j mice at the maximally active dose of 10 mg/kg in vivo. it shows a kd value of 1.08nm in dopamine transporter transfected cos-7 cells. Synonyms: GBR-12935; GBR 12935; GBR12935; 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine; 1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine; Piperazine, 1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl)-;N-[3-tert-Butyl-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N-[4-[2-(4-Morpholinyl)ethoxy]naphthalen-1-yl]urea;1-(2-(Benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine. Grades: 98%. CAS No. 76778-22-8. Molecular formula: C28H34N2O. Mole weight: 414.58. | |
| GBR-12935 dihydrochloride | GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor. Synonyms: GBR12935 dihydrochloride; GBR-12935 dihydrochloride. Grades: 0.99. CAS No. 67469-81-2. Molecular formula: C28H36Cl2N2O. Mole weight: 487.509. | |
| GBR 13069 dihydrochloride | GBR 13069 dihydrochloride is a potent and selecticve inhibitor of dopamine uptake (IC50 = 40 nM). Synonyms: GBR 13069 dihydrochloride; GBR13069 dihydrochloride; GBR-13069 dihydrochloride; (1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride. CAS No. 67469-45-8. Molecular formula: C28H30F2N2O.2HCl. Mole weight: 521.48. | |
| GDP-6-deoxy-a-D-talose | | |
| GDP-D-galactose | GDP-D-galactose, an indispensable biochemical molecule within the biomedical industry, encompasses a pivotal role in enzymatic reactions. As a substrate for glycosylation-involved enzymes, this vital compound becomes essential for the synthesis of diverse glycoproteins and glycolipids. CAS No. 41432-88-6. Molecular formula: C16H25N5O15P2. Mole weight: 589.4. | |
| GDP-D-mannose diammonium salt | GDP-D-mannose diammonium salt is a pivotal compound within the biomedical field assuming the fundamental position as a forerunner for the synthesis of GDP-mannose. This molecule is crucially engaged in glycosylation mechanisms. Molecular formula: C16H23N5O16P2 N2H8. Mole weight: 639.4. | |
| GDP-L-fucose diammonium salt | GDP-L-fucose diammonium salt is an indispensable compound, serving as a vital substrate for fucosyltransferase. This compound intricately contributes to the biosynthesis of fucosylated glycans. Molecular formula: C15H23N5O15P2 N2H8. Mole weight: 623.41. | |
| GDP-L-fucose disodium salt - low endotoxin grade | GDP-L-fucose disodium salt - low endotoxin grade is a remarkably valuable compound within the biomedical realm, used for studying an array of ailments intertwined with cell surface glycans. By functioning as a precursor in fucosylated carbohydrate synthesis, it assumes an indispensable role in facilitating vital cellular adhesion and signaling mechanisms. Molecular formula: C16H23N5O15P2Na2. Mole weight: 633.31. | |
| GDP-L-galactose sodium salt | GDP-L-galactose sodium salt, an indispensable element in the field of biomedicine, assumes a pivotal function in the amalgamation of Vitamin C, thereby facilitating the amelioration of scurvy and associated ailments. This efficacious product showcases its potential in enhancing general well-being and mitigating deficiencies stemming from insufficient levels of Vitamin C. Synonyms: Guanosine 5-diphosphate-L-galactose. CAS No. 6815-91-4. Molecular formula: C16H23N5O16P2Na2. Mole weight: 649.30. | |
| Gemfibrozil Acyl-beta-D-Glucuronide | Gemfibrozil Acyl-beta-D-Glucuronide is the major metabolite of Gemfibrozil. It can be oxidized to a benzyl radical intermediate which binds to the γ-meso position of heme. Synonyms: 1-[5-(2,5-Dimethylphenoxy)-2-dimethylpentanoate] b-D-glucopyranuronic acid. Grades: > 95%. CAS No. 91683-38-4. Molecular formula: C21H30O9. Mole weight: 426.47. | |
| Gemfibrozil b-D-glucuronide-D6 | Gemfibrozil b-D-glucuronide-D6 is a remarkable compound of immense significance, finding its purpose in the therapeutic research of cardiovascular disorders. Specifically tailored to study the levels of cholesterol and triglycerides, this compound manifests its influence as a distinguished PPAR-alpha agonist. Synonyms: 1-[5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoate] b-D-glucopyranuronic acid. Molecular formula: C21H24D6O9. Mole weight: 432.49. | |
| Genistein 7-β-D-Glucuronide | Genistein metabolite. Synonyms: 5-Hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl β-D-Glucopyranosiduronic Acid. Grades: 95%. CAS No. 38482-81-4. Molecular formula: C21H18O11. Mole weight: 446.36. | |
| Genistein D4-7-O-glucoside | | |
| Gevokizumab | Gevokizumab is a monoclonal antibody targeting interleukin 1β (IL-1β), which is a pro-inflammatory cytokine. Gevokizumab has been used in the research of type 2 diabetes mellitus, scleritis and various cancers. CAS No. 1129435-60-4. | |
| GF-109203X | GF-109203X is a potent and highly selective PCK inhibitor, which inhibits PKC isozymes alpha, beta 1, beta 2, gamma, delta and epsilon in vitro. GF-109203X inhibited GSK-3 in vitro, when assayed either in cell lysates (IC(50) 360 nM or in GSK-3beta immunoprecipitates (IC(50) 170 nM derived from rat epididymal adipocytes. Pretreatment of adipocytes with GF-109203X (5 microM) reduced GSK-3 activity in total cell lysates, to 25.1+/-4.3% of control. Synonyms: GF109203X; GF 109203X; Bisindolylmaleimide i; GO 6850; GO-6850; GO6850; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide. Grades: ≥98%. CAS No. 133052-90-1. Molecular formula: C25H24N4O2. Mole weight: 412.49. | |
| GGTI-2154 | GGTI-2154 is a geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2154 results not only in halting the growth of aggressive breast tumors but actually in inducing the regression (54 +/- 3%) of all 19 tumors analyzed. The farnesyltransferase (FTase) inhibitor FTI-2148 induced an average of 87 +/- 3% regression in the 13 tumors analyzed. GGTase I, but not FTase, is inhibited in breast tumors after treatment with GGTI-2154, whereas in tumors from mice treated with FTI-2148, only FTase is inhibited. The processing of the geranylgeranylated proteins RhoA, Rap1, and R-Ras, but not the farnesylated proteins H-Ras and HDJ-2, is inhibited in tumors obtained from mice treated with GGTI-2154. GGTI-2154 and FTI-2148 suppress constitutively activated phospho-Erk1/2 and phospho-Akt, induce apoptosis, and induce differentiation toward ductolobular breast epithelium. Synonyms: GGTI-2154; GGTI 2154; GGTI2154. Grades: 98%. CAS No. 251577-10-3. Molecular formula: C24H28N4O3. Mole weight: 420.51. | |
| GGTI-2166 | GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells. Synonyms: GGTI2166; GGTI2166. Grades: 98%. CAS No. 478908-51-9. Molecular formula: C25H30N4O3. Mole weight: 434.53. | |
| GGTI-297 | GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase). Synonyms: GGTI297; GGTI 297. Grades: 98%. CAS No. 181045-83-0. Molecular formula: C26H31N3O3S. Mole weight: 465.61. | |
| Ghrelin (rat) (acetyl) trifluoroacetate salt | Ghrelin (rat) (acetyl) is a form of ghrelin that is acetylated at serine 3. Ghrelin is a circulating hormone and neuropeptide which binds to the growth hormone (GH) secretagogue receptor (GHS-R). Synonyms: glycyl-L-seryl-O-acetyl-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C141H233N45O42·xCF3COOH. Mole weight: 3230.64. | |
| Ghrelin (rat) (palmitoyl) trifluoroacetate salt | Ghrelin (rat) (palmitoyl) is a palmitoylated form of ghrelin which is a circulating hormone and neuropeptide binding to the growth hormone (GH) secretagogue receptor (GHS-R). Palmitoylated ghrelin is an agonist of GHS-R. Synonyms: glycyl-L-seryl-O-(1-oxohexadecyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C155H261N45O42·xCF3COOH. Mole weight: 3427.01. | |
| Ghrelin (rat) trifluoroacetate salt | Ghrelin is a circulating hormone and neuropeptide which binds to the growth hormone (GH) secretagogue receptor (GHS-R). Grades: ≥95%. Molecular formula: C147H245N45O42·xCF3COOH. Mole weight: 3314.80. | |
| Gimatecan | Gimatecan is an orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities. Gimatecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Although the mechanism of its antiangiogenic activity has yet to be full elucidated, this agent may inhibit endothelial cell migration, tumor neovascularization, and the expression of proangiogenic basic fibroblast growth factor (bFGF). Synonyms: ST1481; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(O-(1,1-dimethylethyl)oxime), (C(E),4S)-; 7-t-Butoxyiminomethylcamptothecin; (4S)-11-((E)-((1,1-DImethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione; NSC793724. Grades: ≥98%. CAS No. 292618-32-7. Molecular formula: C25H25N3O5. Mole weight: 447.48. | |
| Ginkgolic Acid (C15:1) | Ginkgolic Acid is a natural compound with suspected cytotoxic, allergenic, mutagenic and carcinogenic properties. Synonyms: Ginkgoic acid; AK-46666; AK46666; AK 46666; HY-N0077; HYN0077; HY N0077; Ginkgolic acid (15:1); Ginkgolic acid I; Romanicardic acid. Grades: >98%. CAS No. 22910-60-7. Molecular formula: C22H34O3. Mole weight: 346.5. | |
| Ginsenoside Ft1 | | |
| Girentuximab | Girentuximab is a chimeric monoclonal antibody that binds to carbonic anhydrase IX (CAIX), a cell-surface glycoprotein expressed on clear-cell RCC but not on normal kidney cells. Synonyms: G250; cG250. CAS No. 916138-87-9. | |
| Gisadenafil | Gisadenafi is a potent PDE5 inhibitor (IC50 = 1.23 nM). Uses: A potent pde5 inhibitor. Synonyms: UK-369003; UK-369,003; 1-{6-ethoxy-5-[3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridylsulfonyl}-4-ethylpiperazine. Grades: ≥98%. CAS No. 334826-98-1. Molecular formula: C23H33N7O5S. Mole weight: 519.62. | |
| glecaprevir | Glecaprevir is a suppressive agent of hepatitis C virus (HCV). Glecaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 4.09 μM. Uses: The treatment of hepatitis c virus (hcv) infection. Synonyms: ABT 493; (3aR, 7S, 10S, 12R, 21E, 24aR) -7-tert-butyl-N-[ (1R, 2R) -2- (difluoromethyl) -1-{[ (1-methylcyclopropyl) sulfonyl]carbamoyl}cyclopropyl]-20, 20-difluoro-5, 8-dioxo-2, 3, 3a, 5, 6, 7, 8, 11, 12, 20, 23, 24a-dodecahydro-1H, 10H-9, 12-methanocyclopenta[18, 19][1, 10, 17, 3, 6]trioxadiazacyclononadecino[11, 12-b]quinoxaline-10-carboxamide. Grades: 98%. CAS No. 1365970-03-1. Molecular formula: C38H46F4N6O9S. Mole weight: 838.87. | |
| Glembatumumab | Glembatumumab is a human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be linked to monomethyl auristatin E (MMAE) to form Glembatumumab vedotin, an ADC for cancer therapy. Synonyms: Anti-GPNMB. CAS No. 1020264-78-1. | |
| Gliamilide | Gliamilide is a high-potency Sulfonated urea hypoglycemic agent. Uses: Gliamilide is used as a hypoglycemic agent. Synonyms: CP-27,634; CP 27,634; CP27,634; endo-1- ( (4- (2- (2-Methoxynicotinamido) ethyl) piperidino) sulfonyl) -3- (5-norbornen-2-ylmethyl) urea. Grades: 98%. CAS No. 51876-98-3. Molecular formula: C23H33N5O5S. Mole weight: 491.61. | |
| Glofitamab | Glofitamab is a T-cell-engaging bispecific antibody possessing a novel 2:1 structure with bivalency for CD20 on B cells and monovalency for CD3 on T cells. Glofitamab is used as an effective therapy for relapsed or refractory diffuse large B-cell lymphoma. Synonyms: RO7082859; RG6026. CAS No. 2229047-91-8. | |
| GLPG0634 analogue | A potent and selective JAK1 inhibitor with IC50 values of 10, 28, 810, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Synonyms: GLPG0634 analog; N-[5-[4-[(6-cyanopyridin-3-yl)methoxy]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide. Grades: >98%. CAS No. 1206101-20-3. Molecular formula: C23H18N6O2. Mole weight: 410.43. | |
| Glucoiberin | Glucoiberin can be synthesized from Desulfo Glucoraphanin Tetraacetate, a glucosinolate analog of Glucoraphanin found in cruciferous vegetables, e.g., broccoli and cauliflower. Synonyms: 3-(Methylsulfinyl)propyl Glucosinolate; 1-[4-(Methylsulfinyl)-N-(sulfooxy)butanimidate]-1-thio-β-D-glucopyranose. CAS No. 554-88-1. Molecular formula: C11H21NO10S3. Mole weight: 423.48. | |
| Glucosamine sulfate potassium chloride | | |
| Glucosamine Sulfate Sodium Chloride | It appears as a component of heparin and heparin sulfate. Synonyms: D-Glucosamine-2-N-sulfate sodium salt; D-Glucosamine 2-sulfate sodium salt; 2-Deoxy-2-sulfamino-D-glucopyranose sodium salt; GlcN-2S sodium salt; 2-Deoxy-2-sulfoamino-D-glucose Sodium Salt; N-Sulfoglucosamine Sodium Salt. Grades: ≥95%. CAS No. 38899-05-7. Molecular formula: C6H12NNaO8S. Mole weight: 281.22. | |
| Glucose-conjugated MGMT inhibitor | O6BTG-C8-βGlu is a glucose-conjugated MGMT inhibitor. It could reduce the inhibitor's ability to inhibit MGMT. Synonyms: O6BTG-C8-βGlu. Grades: >98%. CAS No. 382607-78-5. Molecular formula: C24H34BrN5O7S. Mole weight: 616.53. | |
| Glucosepane | Glucosepane is a potential target for the research of diabetes and aging-related diseases. It is a type of advanced glycation end-product that accumulates in various tissues, leading to tissue damage and dysfunction. Inhibition of glucosepane formation may help prevent diabetic complications and delay the onset of age-related diseases. Synonyms: (2S)-2-Amino-6-((6R,7S)-2-(((S)-4-amino-4-carboxybutyl)amino)-6,7-dihydroxy-6,7,8,8a-tetrahydroimidazo[4,5-b]azepin-4(5H)-yl)hexanoic acid. CAS No. 257290-23-6. Molecular formula: C18H32N6O6. Mole weight: 428.48. | |
| Glucosylceramide (Soy) | Glucosylceramide is synthesised enzymatically, by the glucosylceramide synthase-catalysed with the addition of a glucose residue to ceramide. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in fungi. Synonyms: Cerebroside (Soy); GlcCer(d18:2/16:0). Grades: >99%. CAS No. 497155-61-0. Molecular formula: C40H75NO9. Mole weight: 714.03. | |
| Glucotropaeolin | Glucotropaeolin is a glucosinolate with antiprotozoal activity against HM1-IMSS E. histolytica, reducing the number of trophozoites (IC50 = 20.4 μg/ml). Glucotropaeolin does not have antitumor activity, but its metabolized isothiocyanate products have these activities. It may decrease spontaneous DNA damage in animals. Synonyms: β-D-Glucopyranose, 1-thio-, 1-[N-(sulfooxy)benzeneethanimidate]; Glucopyranose, 1-thio-, 1-(2-phenylacetohydroximate) NO-(hydrogen sulfate), β-D-; Glucotropeolin; Benzylglucosinolate; Tropaeolin; ( ( (2-phenyl-1- ( ( (2S, 3R, 4S, 5S, 6R) -3, 4, 5-trihydroxy-6- (hydroxymethyl) tetrahydro-2H-pyran-2-yl) thio) ethylidene) amino) oxy) sulfonic acid. Grades: ≥95%. CAS No. 499-26-3. Molecular formula: C14H19NO9S2. Mole weight: 409.43. | |
| Glucuronic acid-GEL | | |
| Glufosfamide | Glufosfamide combines the active part of ifosfamide, a member of a widely used class of chemotherapy drugs known as "alkylators," with a glucose molecule. Because of its glucose component and a tumor cell's increased need for glucose, glufosfamide may be preferentially transported into tumors compared to most normal tissues. Inside cells, the linkage between glucose and the alkylator is cleaved to release the active drug. Synonyms: N,N-Bis(2-chloroethyl)phosphorodiamidic acid beta-D-glucopyranosyl ester. CAS No. 132682-98-5. Molecular formula: C10H21Cl2N2O7P. Mole weight: 383.16. | |
| Glycerite | Sourced from peel of Punica granatum L. It was considered having potential in the prevention of obesity. And modified silver nanoparticles are good candidates for microbicides used in treatment of herpesvirus infections. Glycerite is a natural compound used in cosmetics material. Synonyms: Gallotannin. Grades: >98%. CAS No. 1401-55-4. Molecular formula: C76H52O46. Mole weight: 1701.20. | |
| Glycerol phenylbutyrate | Glycerol phenylbutyrate is a generation ammonia scavenger drug that is currently under development for treatment of urea cyclic disorders, which is a sigma-2 (σ2) receptor ligand. Uses: Glycerol phenylbutyrate is used for treatment of certain inborn urea cycle disorders. Synonyms: HPN-100; 2,3-Bis(4-phenylbutanoyloxy)propyl 4-phenylbutanoate; Ravicti; GPB. Grades: 98%. CAS No. 611168-24-2. Molecular formula: C33H38O6. Mole weight: 530.65. | |
| Glycerone phosphate | Glycerone phosphate, an indispensable entity in biomedicine, serves as a pivotal cog in the intricate machinery of phospholipid biosynthesis. Within the glycerophospholipid metabolic pathway, it assumes a position of utmost importance, facilitating the synthesis of cell membranes. Synonyms: DIHYDROXYACETONE PHOSPHATE; DHAP; Glycerone phosphate; 57-04-5; 1-Hydroxy-3-(phosphonooxy)acetone; 1-hydroxy-3-(phosphonooxy)-2-propanone; 2-Propanone, 1-hydroxy-3-(phosphonooxy)-; dihydroxyacetone 3-phosphate; Dihydroxyacetone monophosphate; 1,3-Dihydroxy-2-propanone phosphate; 3-hydroxy-2-oxopropyl phosphate; 1,3-Dihydroxyacetone 1-phosphate; (3-hydroxy-2-oxopropyl) dihydrogen phosphate; Dihydroxy-Acetone-P; glycerone monophosphate; 1,3-DIHYDROXYACETONEPHOSPHATE; T7KF2T6W95; CHEBI:16108; dihydroxyacetone-P; di-OH-acetone-P; 3-hydroxy-2-oxopropyl dihydrogen phosphate; 1,3-Dihydroxy-2-propanone monodihydrogen phosphate; UNII-T7KF2T6W95; 1ado; glycerone-phosphate1111. CAS No. 57-04-5. Molecular formula: C3H7O6P. Mole weight: 170.06. | |
| Glycerone phosphate dilithium salt | Glycerone phosphate dilithium salt, a highly essential compound extensively employed in the biomedical industry, stands as a pivotal player in diverse metabolic pathways, facilitating the synthesis and regulation of adenosine triphosphate (ATP). With its therapeutic potential, this compound finds utility in the management of specific mitochondrial disorders and holds promise as a candidate for treating metabolic diseases. Synonyms: Dihydroxyacetone phosphate dilithium salt; 1-Hydroxy-3-(phosphonooxy)-2-propanone dilithium salt; DHAP.2Li. CAS No. 102783-56-2. Molecular formula: C3H5Li2O6P. Mole weight: 181.92. | |
| Glycerone phosphate hemimagnesium salt hydrate | Glycerone phosphate hemimagnesium salt hydrate belongs to the class of organic compounds known as monosaccharide phosphates. It has been investigated for the treatment of Lymphoma, Large-Cell, and Diffuse. Synonyms: 1,3-Dihydroxy-2-propanone 1-phosphate hemimagnesium salt hydrate; 1-Hydroxy-3-(phosphonooxy)-2-propanone hemimagnesium salt hydrate; DHAP Mg H2O; Dihydroxyacetone phosphate hemimagnesium salt hydrate. Grades: ≥95%. Molecular formula: C3H7O6P.1/2Mg.xH2O. Mole weight: 362.41 (anydrous basis). | |
| Glycerone phosphate lithium salt | Glycerone phosphate lithium salt is a compound product commonly used in the research of bipolar disorder, acting as a mood stabilizer. Synonyms: Dihydroxyacetone phosphate lithium salt; 1-Hydroxy-3-(phosphonooxy)-2-propanone lithium salt; DHAP. Molecular formula: C3H7O6P xLi. Mole weight: 170.06 (free acid basis). | |
| Glyciphosphoramide | Glyciphosphoramide is a DNA crosslinking agent with anticancer activity. Synonyms: BRN 2012594; BRN2012594; BRN-2012594; M 25; M25; M-25; LS-72312; LS72312; LS72312; Z-6202; Z6202; Z 6202; M 256202; M256202; M-256202; M-25,6202. Grades: >98%. CAS No. 7568-40-3. Molecular formula: C12H24Cl2N3O4P. Mole weight: 376.21. | |
| GNE-272 | GNE-272 is a potent and selective CBP/EP300 inhibitor with IC50s of 0.02, 0.03, 0.41 and 13 μM for CBP, EP300, BRET and BRD4, respectively. It shows significant antiproliferative effects in hematologic cancer cell lines and modulates MYC expression in vivo, corresponding to antitumor activity in AML tumor models. It is also a selective in vivo probe for the Bromodomains of CBP/EP300. Synonyms: (S)-1-(3-((2-fluoro-4-(1-methyl-1h-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5h-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one; N-[2-Fluoro-4-(1-methyl-1H-pyrazole-4-yl)phenyl]-1-[(S)-tetrahydrofuran-3beta-yl]-5-acetyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-amine; 1-(3-{[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-1-[(3S)-oxolan-3-yl]-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one. Grades: ≥95%. CAS No. 1936428-93-1. Molecular formula: C22H25FN6O2. Mole weight: 424.47. | |
| GNE-900 | GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. In combination with chemotherapeutic agents, GNE-900 sustains ATR/ATM signaling, enhances DNA damage, and induces apoptotic cell death. GNE-900 has little single-agent activity in the absence of chemotherapy and does not grossly potentiate the cytotoxicity of gemcitabine in normal bone marrow cells. In vivo scheduling studies show that optimal administration of the ChK1 inhibitor requires a defined lag between gemcitabine and GNE-900 administration. Synonyms: GNE900; GNE 900; 3-(4-(Piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile; 6-cyano-3-(4-piperidin-1-ylmethyl-phenyl)-9H-dipyrido[2,3-b;4',3'-d]pyrrole. Grades: 98%. CAS No. 1200126-26-6. Molecular formula: C23H21N5. Mole weight: 367.45. | |
| GnRH II trifluoroacetate salt | GnRH II is a peptide that is encoded by the GNRH2 gene in humans. It acts as an agonist of the GnRH receptor (GnRHR). Synonyms: Gonadotropin-releasing Hormone II; ?LHRH II; 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-histidylglycyl-L-tryptophyl-L-tyrosyl-L-prolyl-glycinamide, trifluoroacetate salt. Grades: ≥95%. Molecular formula: C60H69N17O13·xCF3COOH. Mole weight: 1236.30. | |
| GO-6976 | Go6976 is a potent PKC inhibitor with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively. It also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively). Synonyms: GO-6976; GO 6976; PD-406976; PD 406976; PD406976. Grades: >98%. CAS No. 136194-77-9. Molecular formula: C24H18N4O. Mole weight: 378.435. | |
| Go6983 | GO6983 is a potent protein kinase C (PKC) inhibitor. GO6893 displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Synonyms: Go6983, Go-6983; Go 6983; GO6983. Grades: >98%. CAS No. 133053-19-7. Molecular formula: C26H26N4O3. Mole weight: 442.519. | |
| Golgicide A | Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. Synonyms: GCA; (3aR,9bS)-rel-6,8-Difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-3H-cyclopenta[c]quinoline; 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)-. Grades: >98%. CAS No. 1139889-93-2. Molecular formula: C17H14F2N2. Mole weight: 284.30. | |
| Gonadorelin Acetate Hydrate (1:x:x) | Cas No. 52699-48-6. | |
| Gossypin | Gossypin is a pentahydroxyflavone glucoside isolated from Hibiscus vitifolius. Gossypin exhibits antioxidant, antiinflammatory, anticancer and antidiabetic activities. Synonyms: 3,3,4,5,7,8-Hexahydroxy flavone-8-glucoside; Gossypetin 8-glucoside. CAS No. 652-78-8. Molecular formula: C21H20O13. Mole weight: 480.38. | |
| GPI-15427 | GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: GPI 15427; GPI15427; 10-((4-Methylpiperazin-1-yl)methyl)chromeno(4,3,2-de)phthalazin-3(2H)-one. CAS No. 805242-85-7. Molecular formula: C20H20N4O2. Mole weight: 348.41. | |
| GPX100 | GPX-100 is an analogue of the anthracycline antineoplastic antibiotic doxorubicin. GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. Synonyms: Epirubicin Impurity 1; 13-Deoxyepirubicin; GPX 100; GPX-100; 13-deoxy-doxorubicin; (1S,3R)-3,5,12-Trihydroxy-3-(2-hydroxyethyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranoside; 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyethyl)-1-methoxy-, (8R,10S)-. Grades: ≥95%. CAS No. 952648-77-0. Molecular formula: C27H31NO10. Mole weight: 529.54. | |
| GPX150 | GPX-150 is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis. Synonyms: GPX 150; GPX-150; 5(8H)-Naphthacenone, 10-((3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy)-7,9,10,12-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyethyl)-12-imino-1-methoxy-, (8R,10S)-. CAS No. 236095-29-7. Molecular formula: C27H32N2O9. Mole weight: 528.56. | |
| Granotapide | Granotapide is used as an antihyperlipidaemic drug candidate. Uses: Granotapide is used as an antihyperlipidaemic drug candidate. Synonyms: JTT130; JTT 130; JTT-130; 2- [ [3- (Dimethylcarbamoyl) -4- [ [4'- (trifluoromethyl) biphenyl-2-yl] carbonylamino] phenyl] acetoxymethyl] -2-phenylmalonic acid diethyl ester. Grades: 98%. CAS No. 594842-13-4. Molecular formula: C39H37F3N2O8. Mole weight: 718.73. | |
| GS-9219 | GS-9219 is a prodrug of the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG) with potential antineoplastic activity. Formulated to selectively accumulate in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite, PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation; subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the induction of apoptosis in susceptible lymphoma cell populations. Synonyms: GS 9219; GS9219. CAS No. 859209-74-8. Molecular formula: C21H35N8O6P. Mole weight: 526.53. | |
| GS9667 | GS9667 is a new selective, partial agonist of the A(1) adenosine receptor (AR). It may be an effective therapy for Type 2 diabetes and dyslipidemia via lowering of free fatty acids (FFA). It was developed by Gilead and was in clinic phase 1 trials without progress. Uses: Gs966 may be an effective therapy for type 2 diabetes and dyslipidemia via lowering of free fatty acids (ffa). Synonyms: GS-9667; GS 9667; CVT-3619; CVT 3619; CVT3619. Grades: 98%. CAS No. 618380-90-8. Molecular formula: C21H24FN5O4S. Mole weight: 461.51. | |
| GS-9822 | GS-9822 is one of novel non-catalytic site integrase inhibitors (NCINIs), which is a potential class of antiretroviral (ARV) agents. GS-9822 exhibits a potent effect against the T174I mutant (EC50: 3.0 ± 0.9 nM) and IN polymorphic variants (fold shift: 0.4 to 1.3). Studies showed that it has excellent pharmacokinetic properties and metabolic stability. Uses: Antiretroviral (arv) agent. Synonyms: GS 9822; GS9822. CAS No. 2219362-41-9. Molecular formula: C36H39ClN4O4S. Mole weight: 659.24. | |
| GSA 10 | GSA 10 is a quinolinecarboxamide derivative that acts as a Smoothened/Smo receptor agonist (EC50 = 1.2 μM). GSA 10 can promote differentiation of multipotent mesenchymal progenitor cells into osteoblasts. Uses: Smoothened (smo) receptor agonist. Synonyms: GSA-10; propyl 4-[(1-hexyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]benzoate. Grades: >98%. CAS No. 300833-95-8. Molecular formula: C26H30N2O5. Mole weight: 450.53. | |
| GS-CA-1 | GS-CA-1 is a novel HIV capsid inhibitor developed by Gilead, which is a promisingly long-acting antiretroviral (ARV) agent. The preclinical study showed that GS-CA-1 could inhibit HIV-1 replication in human peripheral blood mononuclear cells (PBMCs) (EC50 = 140 pM). Uses: Long-acting antiretroviral (arv) agent. Synonyms: GS CA 1. Grades: 99.94%. CAS No. 2189684-45-3. Molecular formula: C41H36ClF8N7O5S2. Mole weight: 958.34. | |
| GSK143 | GSK143 is a selective SYK inhibitor, which abrogates survival signals in chronic lymphocytic leukaemia. Synonyms: 2-{[(3r,4r)-3-Aminotetrahydro-2h-Pyran-4-Yl]amino}-4-[(4-Methylphenyl)amino]pyrimidine-5-Carboxamide. CAS No. 1240390-27-5. Molecular formula: C17H22N6O2. Mole weight: 342.40. | |
| GSK180736A | GSK180736A is a potent and selective inhibitor of GRK2 (IC50 = 0.77 μM) and ROCK1 (IC50 = 14 nM). Synonyms: GSK-180736A; 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide. Grades: >98%. CAS No. 817194-38-0. Molecular formula: C19H16FN5O2. Mole weight: 365.37. | |
| GSK-189254 | Cas No. 945493-87-8. | |
| GSK 269962 | GSK 269962 is a potent ROCK inhibitor with IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively, which displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. It may be used in OAB treatment. It has been shown to block the generation of inflammatory cytokines in lipopolysaccharide-stimulated monocytes and to induce vasorelaxation in preconstricted rat aorta (IC50 = 35 nM). It lowers blood pressure in a rat model of hypertension. It induced a reduction in blood pressure of approximately 10, 20, and 50 mm Hg at doses of 1, 3, and 30 mg/kg. It represent a novel class of ROCK inhibitors that have profound effects in the vasculature, which may enable us to further evaluate the potential beneficial effects of ROCK inhibition in animal models of cardiovascular as well as other chronic diseases. Uses: Gsk 269962 may be used in oab treatment. it represent a novel class of rock inhibitors. Synonyms: GSK269962A; N-[3-[[2-(4-Aminofurazan-3-yl)-1-ethyl-1H-imidazo[4, 5-c]pyridin-6-yl]oxy]phenyl]-4-[[2-(4-morpholinyl)ethyl]oxy]benzamide; Aminofurazanyl-azabenzimidazole 6n;N-[3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-6-yl]oxyphenyl]-4-(2-morpholin-4-ylethoxy)benzamide. Grades: >99 %. CAS No. 850664-21-0. Molecular formula: C29H30N8O5. Mole weight: 570.60. | |
| GSK-270822A | GSK-270822A is a G protein-coupled receptor kinases(GRK2) inhibitor, which has been directly implicated in the progression of heart failure. It would be used as useful chemical probes and leads for therapeutic applications ranging from heart failure to Parkinson's disease. Uses: Gsk-270822a would be used as useful chemical probes and leads for therapeutic applications ranging from heart failure to parkinson's disease. Synonyms: GSK270822A; GSK 270822A; N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxamide; NSC-756163. Grades: 98%. CAS No. 864082-23-5. Molecular formula: C24H20N4O2. Mole weight: 396.45. | |
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