BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| ELA | ELA is a ELABELA mutant peptide and also a negative control for ELA-32. Elabela is one of two endogenous ligands for the G-protein-coupled APLNR receptor. Molecular formula: C162H271N57O39S4. Mole weight: 3769.55. |  |
| ELA-14 negative control | Negative control for ELA-14. Synonyms: H-Pyr-Arg-Arg-Cys-Met-Pro-Leu-His-Ser-Ala-Val-Pro-Phe-Pro-OH. CAS No. 1885873-44-8. Molecular formula: C72H112N22O17S2. Mole weight: 1621.93. | |
| ELA-32 (human) | ELA-32 (human) is a potent apelin receptor agonist (IC50 = 0.27 nM; Kd=0.51 nM) stimulating the PI3K/AKT pathway and promoting self-renewal of hESCs via cell-cycle progression and protein translation. It also potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage. Synonyms: ELA-32 (human); ELA 32 (human); ELA32 (human). Grades: >98%. CAS No. 1680205-79-1. Molecular formula: C170H289N63O39S4. Mole weight: 3967.8. | |
| Elacytarabine | Elacytarabine (CP-4055) is the lipophilic 5'-elaidic acid ester of the deoxycytidine analog cytosine arabinoside (cytarabine; Ara-C) with potential antineoplastic activity. As a prodrug, CP-4055 is converted intracellularly into cytarabine triphosphate by deoxycytidine kinase and subsequently competes with cytidine for incorporation into DNA, thereby inhibiting DNA synthesis. Compared to cytarabine, CP-4055 shows increased cellular uptake and retention, resulting in increased activation by deoxycytidine kinase to cytarabine triphosphate, decreased deamination and deactivation by deoxycytidine deaminase, and increased inhibition of DNA synthesis. This agent also inhibits RNA synthesis, an effect not seen with cytarabine. Synonyms: CP-4055; CP 4055; CP4055; 5'-O-(Elaidoyl) 1-beta-D-arabinofuranosylcytosine; 5'-Oleoyl cytarabine; (E)-((2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl octadec-9-enoate. CAS No. 188181-42-2. Molecular formula: C27H45N3O6. Mole weight: 507.67. | |
| Elagolix | Elagolix is a Gonadotropin-Releasing Hormone (GnRH) Antagonist. Elagolix inhibits gonadatropin releasing hormone (GnRH) receptors in the pituitary gland and ultimately reduces circulating sex hormone levels. To date, elagolix has been studied in over 20 clinical trials totaling more than 1,000 subjects. A Phase 2a trial of elagolix for the treatment of uterine fibroids is also ongoing. Endometriosis can be a debilitating disease that affects millions of women around the world and the exploration of new treatments could offer other options for women with this disease. Synonyms: Elagolix, Elagolix sodium, NBI-56418; NBI 56418; NBI56418. CAS No. 834153-87-6. Molecular formula: C32H30F5N3O5. Mole weight: 631.6. | |
| Eldelumab | Eldelumab is a humanized anti-CXCL10 (IP-10) monoclonal antibody that binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab has been use for the treatment of ulcerative colitis. Synonyms: BMS-936557; MDX-1100. CAS No. 946414-98-8. | |
| Elenestinib | Elenestinib is a next-generation KIT D816V inhibitor. Elenestinib exhibits potent inhibition of KIT D816V and an evolved pre-clinical profile with limited central nervous system penetration. Synonyms: BLU-263. CAS No. 2505078-08-8. Molecular formula: C27H29FN10O. Mole weight: 528.6. | |
| Eleutheroside E | Eleutheroside E has anti-inflammatory effect by inhibiting NF-κB activities. Uses: Anti-inflammatory. Synonyms: Acanthoside D; Eleutheroside E. Grades: >98%. CAS No. 39432-56-9. Molecular formula: C34H46O18. Mole weight: 742.72. | |
| Elisidepsin | Elisidepsin is a marine-derived, synthetic cyclic depsipeptide with potential antineoplastic activity. Elisidepsin is a derivative of a natural marine compound that belongs to a family of dehydro aminobutyric acid-containing peptides (kahalalides) isolated from the herbivorous marine mollusk Elysia rufescens. Although the primary mechanism of action has yet to be elucidated, this agent exhibits anti-proliferative activity in a wide variety of cancer cell types, including breast, colon, pancreas, lung, and prostate; it appears to induce oncolytic rather than apoptotic cell death. Synonyms: PM-02734; N-[(4S)-4-methylhexanoyl]-D-valyl-L-threonyl-L-valyl-D-valyl-D-prolyl-L-ornithyl-N-{(3S,6Z,9S,12R,15R,18R,19R)-9-benzyl-15-[(2S)-butan-2-yl]-6-ethylidene-3,12-diisopropyl-19-methyl-2,5,8,11,14,17-hexaoxo-1-oxa-4,7,10,13,16-pentaazacyclononadecan-18-yl}-D-alloisoleucinamide. CAS No. 681272-30-0. Molecular formula: C75H124N14O16. Mole weight: 1477.90. | |
| Elomotecan | Elomotecan (BN-80927) belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered beta-hydroxylactone ring. Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase experiments and quantification of DNA-protein-complexes stabilization, have confirmed the higher potency of BN80927 as compared with the Topo I inhibitor SN38. In addition, BN80927 inhibits Topo II-mediated DNA relaxation in vitro but without cleavable-complex stabilizatio...th assays, BN80927 is a very potent antiproliferative agent as shown by IC(50) values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. BN80927 shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate tumors PC3 and DU145. Altogether, these data strongly support the clinical development of BN80927. Synonyms: BN-80927; BN80927; BN 80927; R-1559; R1559; R 1559; (R)-9-chloro-5-ethyl-5-hydroxy-10-methyl-12-((4-methylpiperidin-1-yl)methyl)-4, 5-dihydrooxepino[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 15(1H, 13H)-dione. CAS No. 220998-10-7. Molecular formula: C29H32ClN3O4. Mole weight: 522.04. | |
| Eltrombopag Acyl Glucuronide | | |
| Eluxadoline-glucuronide | Molecular formula: C38H43N5O11. Mole weight: 745.8. | |
| Emapalumab | Emapalumab is an anti-interferon-gamma (IFNγ) monoclonal antibody approved for the treatment of primary hemophagocytic lymphohistiocytosis (HLH). Synonyms: Gamifant; NI-0501; NI 0501; NI0501. CAS No. 1709815-23-5. | |
| EMD534085 | EMD534085 is a potent and selective mitotic kinesin-5 inhibitor with an IC50 of 8 nM. Synonyms: 1-(2-(Dimethylamino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano(3,2-C)quinolin-2-yl)methyl)urea; EMD-534085; EMD 534085; N-[2-(Dimethylamino)ethyl]-N'-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]urea. Grades: ≥95%. CAS No. 858668-07-2. Molecular formula: C25H31F3N4O2. Mole weight: 476.53. | |
| Emibetuzumab | Emibetuzumab is a humanized monoclonal antibody targeting HGFR. Emibetuzumab induces internalization and degradation of MET, inhibiting proliferation of tumor cells with MET amplification and providing antitumor activity in xenograft models of NSCLC. Synonyms: LY2875358. CAS No. 1365287-97-3. | |
| Emicerfont | Emicerfont is a Corticotropin releasing factor receptor 1 antagonist. It can block the CRF1 receptor and so reduce ACTH release. It has been investigated for the treatment of irritable bowel syndrome (IBS) and alcoholism. In Feb 2008, GlaxoSmithKline completed enrolment in its Phase-II trial for Irritable bowel syndrome in the US and Canada. Uses: Irritable bowel syndrome (ibs) and alcoholism. Synonyms: GW876008; 1-{1-[1-(4-Methoxy-2-methylphenyl)-6-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl}imidazolidin-2-one; GW876008X; 2-Imidazolidinone, 1-[1-[2,3-dihydro-1-(4-methoxy-2-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl]-. Grades: 98%. CAS No. 786701-13-1. Molecular formula: C22H24N6O2. Mole weight: 404.47. | |
| Emicizumab | Emicizumab is a bispecific monoclonal antibody that binds to both the activated coagulation factor IX and to factor X. Emicizumab has been used in the management and treatment of hemophilia A. Synonyms: Hemlibra. CAS No. 1610943-06-0. | |
| Emodin-1-Beta-D-Glucoside | Emodin-1-Beta-D-Glucoside is an antioxidant and anti-inflammatory compound used for studying cancer, inflammation and microbial infections. Synonyms: Emodin 1-O-beta-D-glucoside; Emodin-1-O-glucoside; Emodin-1-O-|A-D-glucopyranoside; Emodin-1-Beta-D-Glucoside; 513F53H6BU; Emodin-1-O-beta-D-glucopyranoside; UNII-513F53H6BU; 1,3-dihydroxy-6-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyanthracene-9,10-dione; EMODIN 1-GLUCOSIDE; 9,10-Anthracenedione, 1-(beta-D-glucopyranosyloxy)-6,8-dihydroxy-3-methyl-; modin 1-glucoside; EMODIN-1-GLUCOSIDE; Emodin 1-Beta-D-Glucoside; Emodin-1-O-beta-D-glucoside; CHEMBL457945; Emodin-1-O-b-D-glucopyranoside; DTXSID201020031; Emodin-1-O-??-D-glucopyranoside; EMODIN 1-.BETA.-GLUCOSIDE; HY-N2394; AKOS030573570; EMODIN 1-O-.BETA.-D-GLUCOSIDE; AC-34144; MS-27708; 1-O-.BETA.-D-GLUCOPYRANOSYLEMODIN; EMODIN 1-.BETA.-D-GLUCOPYRANOSIDE; CS-0022596; EMODIN 1-O-.BETA.-D-GLUCOPYRANOSIDE; F17665; Q27260855; 9,10-ANTHRACENEDIONE, 1-(.BETA.-D-GLUCOPYRANOSYLOXY)-6,8-DIHYDROXY-3-METHYL-. Grades: > 95%. CAS No. 38840-23-2. Molecular formula: C21H20O10. Mole weight: 432.38. | |
| Emodin-1-O-b-D-glucopyranoside | Synonyms: Emodin 1-O-beta-D-glucoside; Emodin-1-O-glucoside; Emodin-1-O-|A-D-glucopyranoside; Emodin-1-Beta-D-Glucoside; 513F53H6BU; Emodin-1-O-beta-D-glucopyranoside; UNII-513F53H6BU; 1,3-dihydroxy-6-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyanthracene-9,10-dione; EMODIN 1-GLUCOSIDE; 9,10-Anthracenedione, 1-(beta-D-glucopyranosyloxy)-6,8-dihydroxy-3-methyl-; modin 1-glucoside; EMODIN-1-GLUCOSIDE; Emodin 1-Beta-D-Glucoside; Emodin-1-O-beta-D-glucoside; CHEMBL457945; Emodin-1-O-b-D-glucopyranoside; DTXSID201020031; Emodin-1-O-??-D-glucopyranoside; EMODIN 1-.BETA.-GLUCOSIDE; HY-N2394; AKOS030573570; EMODIN 1-O-.BETA.-D-GLUCOSIDE; AC-34144; MS-27708; 1-O-.BETA.-D-GLUCOPYRANOSYLEMODIN; EMODIN 1-.BETA.-D-GLUCOPYRANOSIDE; CS-0022596; EMODIN 1-O-.BETA.-D-GLUCOPYRANOSIDE; F17665; Q27260855; 9,10-ANTHRACENEDIONE, 1-(.BETA.-D-GLUCOPYRANOSYLOXY)-6,8-DIHYDROXY-3-METHYL-. Molecular formula: C21H20O10. Mole weight: 432.4. | |
| (-)-Emtricitabine triphosphate | (-)-Emtricitabine triphosphate, an antiviral drug, is commonly prescribed for HIV-1 infection. It suppresses virus replication by inhibiting the reverse transcriptase enzyme. Consequently, the viral load decreases, and immune efficacy increases, delaying the onset of AIDS. Synonyms: Triphosphoric acid P-[[(2R,5S)-5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolan-2-yl]methyl] ester sodium; Triphosphoric Acid (2R-cis)-P-[[5-(4-Amino-5- fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolan-2-yl]methyl] Ester Sodium. CAS No. 145819-92-7. Molecular formula: C8H9FN3Na4O12P3S. Mole weight: 575.11. | |
| Enfortumab | Enfortumab is a monoclonal antibody targeting Nectin-4. Enfortumab has been used for the treatment of urothelial cancer. CAS No. 1448664-46-7. | |
| Enibarcimab | Enibarcimab is a humanized monoclonal antibody that has been investigated as a medication for the treatment of acute heart failure and COVID-19. Synonyms: HAM 8101; HAM-8101; HAM8101. CAS No. 2305638-98-4. | |
| Eniluracil | Eniluracil, also known as GW776 and GW776C85, is an orally active and irreversible inhibitor of dihydropyrimidine dehydrogenase. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil (5-FU) in the liver. Co-administration of ethynyluracil permits the oral administration of 5-FU. Uses: Enzyme inhibitors. Synonyms: 5-ethynyluracil; 5-ethynylpyrimidine-2,4(1H,3H)-dione; 5-Ethynyl-2-hydroxypyrimidin-4(1H)-one; GW776; GW-776; GW 776. CAS No. 59989-18-3. Molecular formula: C6H4N2O2. Mole weight: 136.11. | |
| ENMD-1198 | ENMD-1198 is an analog of 2-methoxyestradiol (2ME2) with antiproliferative and antiangiogenic activity. ENMD-1198 is a novel tubulin-binding agent that reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells. Synonyms: IRC-110160; 2-methoxyoestra-1,3,5(10),16-tetraene-3-carboxamide. Grades: 98%. CAS No. 864668-87-1. Molecular formula: C20H25NO2. Mole weight: 311.42. | |
| Enokizumab | Enokizumab is a monoclonal antibody targeting interleukin-9. Synonyms: MEDI-528; MEDI 528; MEDI528. CAS No. 909875-08-7. | |
| Entacapone 3-b-D-glucuronide | Entacapone 3-b-D-glucuronide is a metabolite of Entacapone, which is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) used in combination with other medications for the treatment of Parkinson's disease. Synonyms: β-D-Glucopyranosiduronic acid, 5-[(1E)-2-cyano-3-(diethylamino)-3-oxo-1-propen-1-yl]-2-hydroxy-3-nitrophenyl; 5-[(1E)-2-Cyano-3-(diethylamino)-3-oxo-1-propen-1-yl]-2-hydroxy-3-nitrophenyl β-D-glucopyranosiduronic acid; β-D-Glucopyranosiduronic acid, 5-[(1E)-2-cyano-3-(diethylamino)-3-oxo-1-propenyl]-2-hydroxy-3-nitrophenyl; β-D-Glucopyranosiduronic acid, 5-[2-cyano-3-(diethylamino)-3-oxo-1-propenyl]-2-hydroxy-3-nitrophenyl, (E)-; Entacapone 3-β-D-glucuronide. Grades: ≥95%. CAS No. 158069-75-1. Molecular formula: C20H23N3O11. Mole weight: 481.41. | |
| Entasobulin | Entasobulin is a tubulin polymerization inhibitor with potential anticancer activity. Entasobulin is a indolizine-glyoxylamide based small molecule that demonstrate substantial in vitro anti-proliferative activities against cancer cell lines, including multidrug resistance (MDR) phenotypes. The in vitro cytotoxic effects have been demonstrated across a wide array of tumor types of various origins (e.g., breast, colon, uterine). Synonyms: Entasobulin; UNII-TB77GU6BFO; UNII TB77GU6BFO. CAS No. 501921-61-5. Molecular formula: C26H18ClN3O2. Mole weight: 439.89. | |
| Entecavir 3-O-b-D-glucuronide | Entecavir 3-O-b-D-glucuronide is an essential compound utilized within the biomedical realm, boasting its efficaciousness in studying the persisting malady of chronic hepatitis B virus (HBV) infection. Functioning as an exemplary antiviral entity, it effectively impedes the retrograde transcription of HBV DNA, thus curbing viral replication. Molecular formula: C18H23N5O9. Mole weight: 453.40. | |
| Envafolimab | Envafolimab is a recombinant protein of a humanized single-domain anti-PD-L1 antibody. Envafolimab has obtained the U.S. FDA's orphan drug designation for advanced biliary tract cancer. Synonyms: ASC 22; ASC22; ASC-22; KN 035; KN035; KN-035. CAS No. 2102192-68-5. | |
| (E)-Ozagrel hydrochloride | Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. Uses: Enzyme inhibitors. Synonyms: ozagrel hydrochloride; OKY-046 hydrochloride. Grades: >98%. CAS No. 78712-43-3. Molecular formula: C13H13ClN2O2. Mole weight: 264.71. | |
| Epiandrosterone b-D-glucuronide | Epiandrosterone is an innate steroid hormone, and Epiandrosterone b-D-glucuronide manifests as a glucuronide conjugate. Predominantly employed in the realm of biomedical inquiry, it is used to unravel the intricate web of Epiandrosterone's metabolism and excretion within the corporeal domain. Synonyms: (3b,5a)-17-Oxoandrostan-3-yl b-D-glucopyranosiduronic acid; 17-Oxo-5a-androstan-3b-yl b-D-glucopyranosiduronic acid; 17-Oxo-5a-androstan-3b-yl b-D-glucosiduronic acid. CAS No. 4271-00-5. Molecular formula: C25H38O8. Mole weight: 466.56. | |
| epi-Inositol | epi-Inositol is a multifunctional natural compound for the research of insulin resistance and polycystic ovary syndrome (PCOS) because of its exceptional insulin-sensitizing properties. Uses: A growth factor in many plants and animals; used as a nutritional supplement; an isomer of glucose that has traditionally been considered to be a b vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. Synonyms: inositol; myo-inositol; Scyllo-inositol; epi-Inositol; Muco-Inositol; Allo-inositol; i-Inositol;meso-Inositol; Neo-inositol; D-chiro-Inositol; 1L-Chiro-inositol; D-(+)-chiro-Inositol; cis-Inositol;1D-Chiro-inositol; Myoinositol; Scyllitol; Cyclohexane-1,2,3,4,5,6-hexaol;(1r,2r,3r,4r,5r,6r)-cyclohexane-1,2,3,4,5,6-hexol; (1r,2R,3S,4r,5R,6S)-cyclohexane-1,2,3,4,5,6-hexol; 1,3,5/2,4,6-Hexahydroxycyclohexane; (1R,2R,3R,4R,5S,6S)-Cyclohexane-1,2,3,4,5,6-hexaol; 1-L-chiro-Inositol; Inositol, D-chiro-; (+)-Chiro-Inositol. CAS No. 488-58-4. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| epi-Kifunensine | epi-Kifunensine is a catalytically potent inhibitor of α-mannosidase I enzyme. By illuminating the multifaceted functions of α-mannosidase I in intricate protein glycosylation pathways, this product emerges as an indispensable tool fostering profound comprehension of glycoprotein biosynthesis. Moreover, its salience extends to study advancements targeting α-mannosidase I dysfunction-driven maladies, notably lysosomal storage disorders. Synonyms: (5R,6R,7S,8R,8aR)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione. Molecular formula: C8H12N2O6. Mole weight: 232.19. | |
| Epilotaustralin Tetraacetate | Epilotaustralin Tetraacetate is an intermediate in the synthesis of (R)-Lotaustralin, which is a bioactive constituent of Chinese natural medicines. Synonyms: Epilotaustralin Tetraacetate (Ester). CAS No. 27749-92-4. Molecular formula: C19H27NO10. Mole weight: 429.42. | |
| Episilvestrol | Episilvestrol is a derivative of Silvestrol, which is a member of flavagline family of natural products from the genus of Aglaia. Uses: Tyrosine kinase/adaptors. Synonyms: Methyl (1R,2R,3S,3aR,8bS)-6-({(2S,3R,6R)-6-[(1S)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl}oxy)-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d] furan-2-carboxylate. Grades: ≥95%. CAS No. 697235-39-5. Molecular formula: C34H38O13. Mole weight: 654.66. | |
| Epoprostenol Sodium | Epoprostenol Sodium is the sodium salt form of epoprostenol, which is a synthetic prostacyclin. It has vasodilatory and anticoagulant activity. It is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It prevents the formation of platelet plugs and is an effective vasodilator. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase. It directly simulates prostaglandin receptors in arterial vascular smooth muscle, thereby causing vasodilatation. lt is also used for the treatment of pulmonary hypertension. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. It is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract. It was developed by GlaxoSmithKline and has been listed. Uses: Epoprostenol sodium has vasodilatory and anticoagulant activity. it prevents the formation of platelet plugs and is an effective vasodilator. lt is also used for the treatment of pulmonary hypertension. Synonyms: Prostacyclin Sodium Salt; (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-Dihydroxy-prosta-5,13-dien-1-oic Acid Sodium Salt; Flolan. Grades: >99 %. CAS No. 61849-14-7. Molecular formula: C20H31O5Na. Mole weight: 374.45. | |
| Eprazinone dihydroChloride | Eprazinone dihydrochloride is a drug with proposed mucolytic, secretolytic, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. It has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen. Uses: Expectorants. Synonyms: 3-[4-(β-Ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone, Dihydrochloride; 746CE; Eftapan; Eprazinone Hydrochloride; Mucitux; NSC 317935; Resplen. Grades: >98%. CAS No. 10402-53-6. Molecular formula: C24H34Cl2N2O2. Mole weight: 453.44. | |
| Eptinezumab | Eptinezumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP). Eptinezumab has been used for the preventive treatment of migraine in adults. Synonyms: Vyepti. CAS No. 1644539-04-7. | |
| EPZ004777 | EPZ004777 is a potent, selective inhibitor of DOT1L. Treatment of mixed lineage leukemia (MLL) cells with EPZ004777 selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non-MLL-translocated cells. Finally, in vivo administration of EPZ004777 leads to extension of survival in a mouse MLL xenograft model. These results provide compelling support for DOT1L inhibition as a basis for targeted therapeutics against MLL. Uses: Reprogramming. Synonyms: EPZ004777; EPZ 004777; EPZ-004777. Grades: 0.98. CAS No. 1338466-77-5. Molecular formula: C28H41N7O4. Mole weight: 539.681. | |
| Equilin 3-O-beta-D-Glucuronide Sodium Salt | A derivative of Equilin. Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: 17-Oxoestra-1,3,5(10),7-tetraen-3-yl β-D-Glucopyranosiduronic Acid Monosodium Salt. Grades: > 95%. CAS No. 27610-12-4. Molecular formula: C24H27O8 Na. Mole weight: 466.46. | |
| Equol | Cas No. 531-95-3. | |
| ER-67880 | ER-67880 is a novel and potent microtubule inhibitor with potential anticancer activity. Synonyms: ER 67880; ER67880; N-(3-chloro-1H-indol-7-yl)-4-methoxy-benzenesulfonamide. Grades: 98%. CAS No. 247186-96-5. Molecular formula: C15H13ClN2O3S. Mole weight: 336.79. | |
| ER-805751 | ER-805751 is a potent proteasome inhibitor. Synonyms: ER-80575; ER805751; ER 805751. Grades: 98%. CAS No. 565454-88-8. Molecular formula: C25H30N2O6. Mole weight: 454.52. | |
| Eragidomide | Eragidomide is a modulator of the E3 ligase cereblon and has antineoplastic activity. Synonyms: rac-2-(4-chlorophenyl)-N-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide; CC-90009; Cereblon modulator 1; NSC828250; CC 90009; CC90009; 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-benzeneacetamide. Grades: ≥98% by HPLC. CAS No. 1860875-51-9. Molecular formula: C22H18ClF2N3O4. Mole weight: 461.85. | |
| Erenumab | Erenumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide (CGRP). Erenumab has been used for the preventive treatment of migraines. Synonyms: Aimovig. CAS No. 1582205-90-0. | |
| E-Retinyl b-glucuronide | E-Retinyl b-glucuronide is a biomedical compound, used for studying retinal diseases. Derived from retinol, this compound is indispensable in preserving visual acuity and upholding retinal well-being. Synonyms: all-trans-Retinyl b-glucuronide. CAS No. 16639-19-3. Molecular formula: C26H38O7. Mole weight: 462.58. | |
| Erteberel | Erteberel is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor &alpha. Synonyms: LY500307; (3aS, 4R, 9bR) -1, 2, 3, 3a, 4, 9b-Hexahydro-4- (4-hydroxyphenyl) cyclopenta[c][1]benzopyran-8-ol; (2R,6S,7R)-7-(4-hydroxyphenyl)-8-oxatricyclo[7.4.0.02,6]trideca-1(13),9,11-trien-12-ol; Benzo[b]cyclopenta[d]pyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)-. Grades: >98%. CAS No. 533884-09-2. Molecular formula: C18H18O3. Mole weight: 282.33. | |
| Ertiprotafib | Ertiprotafib is an inhibitor of protein tyrosine phosphatase 1B (PTP1B), IkB kinase β (IKK-β), and a dual agonist of PPARα and PPARβ, with IC50s of 1.6 μM and 400 nM for PTP1B and IKK-β, and EC50s of ~1 μM for PPARα/PPAR&beta. It is potentially useful for the treatment of non-insulin dependent diabetes. Synonyms: PTP 112; Benzenepropanoic acid, α-[4-(9-bromo-2,3-dimethylnaphtho[2,3-b]thien-4-yl)-2,6-dimethylphenoxy]-, (αR)-; (2R)-2-(4-(9-Bromo-2,3-dimethylnaphtho(2,3-b)thiophen-4-yl)-2,6-dimethylphenoxy)-3-phenylpropionic acid; (αR)-α-[4-(9-Bromo-2,3-dimethylnaphtho[2,3-b]thien-4-yl)-2,6-dimethylphenoxy]benzenepropanoic Acid. Grades: 98%. CAS No. 251303-04-5. Molecular formula: C31H27BrO3S. Mole weight: 559.52. | |
| Erucin | Erucin is an isothiocyanate derived from glucoerucin, a glucosinolate predominant in arugula (Eruca sativa Mill.) and other cruciferous vegetables. Erucin exhibits antioxidant and antiproliferative effects in cancer cell lines, and induces cell apoptosis. Synonyms: 4-methylthiobutyl isothiocyanate; 4-(Methylthio)butyl isothiocyanate; 1-isothiocyanato-4-methylsulfanylbutane. CAS No. 4430-36-8. Molecular formula: C6H11NS2. Mole weight: 161.281. | |
| Esorubicin | Esorubicin is a synthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin with potential antineoplastic activity. Esorubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause more severe myelosupression compared to other compounds within the anthracycline class. Uses: Antibiotics, antineoplastic. Synonyms: Deoxyadriamycin; Deoxydoxorubicin; IMI-58; IMI 58; IMI58; (8S,10S)-10-[[(2S,4R,6S)-4-Aminotetrahydro-6-methyl-2H-pyran-2-yl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; [2S-[2α(8R*, 10R*), 4β, 6β]]-10-[(4-Aminotetrahydro-6-methyl-2H-pyran-2-yl)oxy]-7, 8, 9, 10-tetrahydro-6, 8, 11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5, 12-naphthacenedione; 4'-Deoxyadriamycin; 4'-Deoxydoxorubicin; NSC 267469. CAS No. 63521-85-7. Molecular formula: C27H29NO10. Mole weight: 527.53. | |
| Esreboxetine succinate | Esreboxetine succinate is a selective norepinephrine reuptake inhibitor. It was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia. Uses: Esreboxetine succinate was used for the treatment of neuropathic pain and fibromyalgia. Synonyms: (S,S)-reboxetine succinate; (+) - (2S) -2- ( (S) - (2-Ethoxyphenoxy) phenylmethyl) morpholine hydrogen butanedioate. Grades: 98%. CAS No. 635724-55-9. Molecular formula: C23H29NO7. Mole weight: 431.48. | |
| Estradiol 3-sulfate 17b-glucuronide dipotassium salt | Introducing Estradiol 3-sulfate 17b-glucuronide dipotassium salt is a profoundly efficacious steroid compound playing a pivotal role as an estrogen receptor agonist. This compoundously versatile substance is used in the research of hormone therapy and estrogen-dependent afflictions. Synonyms: (17b)-3-(Sulfooxy)estra-1,3,5(10)-trien-17-yl b-D-glucopyranosiduronic acid dipotassium salt. CAS No. 10392-35-5. Molecular formula: C24H32K2O11S. Mole weight: 606.77. | |
| Estrone D5 b-D-glucuronide | | |
| Etalocib | LY293111, a novel diaryl ether carboxylic acid derivative, is a potent and selective inhibitor of the lipoxygenase pathway either directly through 5'-lipoxygenase or via antagonism of the leukotriene B4 (LTB4) receptor. LY293111 has antineoplastic activity in a variety of preclinical models. Synonyms: LY293111; VML 295; 2-[3-[3-[(5-Ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic Acid; 2- [2-Propyl-3- [3- [2-ethyl-4- (4-fluorophenyl) -5-hydroxyphenoxy] propoxy] phenoxy] benzoic acid. Grades: ≥98%. CAS No. 161172-51-6. Molecular formula: C33H33FO6. Mole weight: 544.61. | |
| Etanercept | Etanercept inhibits in vitro the activity of human TNF and is efficacious in many in vivo models of inflammation, including arthritis. Etanercept competitively inhibits the binding of both TNF-α and TNF-β (lymphotoxin-α) to cell surface TNF receptors, rendering TNF biologically inactive. It also modulates indirectly different biological responses that are induced or regulated by TNF, such as the expression of adhesion molecules E-selectin and to a lesser extent intercellular adhesion molecule 1 (ICAM-1), the production of interleukin-6 (IL-6) and matrix metalloproteinase 3 (MMP-3) (stromelysin), as well as IL1. Synonyms: 1-235-Tumor necrosisfactor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human g1-chain Fc fragment); TNFR-Fc fusion protein; Etanercept; Embrel; Enbrel; rhu-TNFR-Fc. Grades: 95%. CAS No. 185243-69-0. Molecular formula: C2224H3472N618O701S36. | |
| eteplirsen | Eteplirsen is a drug developed for the treatment of some mutations resulting in Duchenne muscular dystrophy (DMD). It has an effect of decreasing dystrophin levels from baseline in muscle tissues in the therapy. Eteplirsen has received orphan drug designation in the USA and EU, and rare paediatric disease designation in the USA used for DMD. Uses: The treatment of duchenne muscular dystrophy (dmd). Synonyms: Exondys 51; AVI-4658; AVI4658; AVI 4658. CAS No. 1173755-55-9. Molecular formula: C364H569N177O122P30. Mole weight: 10305.738. | |
| Etesevimab | Etesevimab is a human recombinant monoclonal antibody that targets the SARS-CoV-2 surface spike protein receptor-binding domain. Etesevimab has been authorized for emergency use by the FDA for the treatment of COVID-19. Synonyms: LY-CoV016; JS016. CAS No. 2423948-94-9. | |
| Ethinyl Estradiol-3-Glucuronide | A derivative of Estradiol. Estradiol? is the major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female genotype in embryogenesis and at puberty. Synonyms: (17a)-17-Hydroxy-19-norpregna-1,3,5(10)-trien-20-yn-3-yl b-D-glucopyranosiduronic acid; 17a-Ethynylestradiol 3-glucuronide. Grades: > 95%. CAS No. 60134-76-1. Molecular formula: C26H32O8. Mole weight: 472.53. | |
| Ethonafide | Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerated and more effective at inhibiting tumor growth compared with mitoxantrone in a human xenograft tumor regression mouse model. Mechanistically, we found that ethonafide inhibited topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIalpha and -beta. In addition, ethonafide induced a potent G(2) cell cycle arrest in the DU 145 human prostate cancer cell line. By creating stable cell lines with decreased expression of topoisomerase IIalpha or -beta, we found that a decrease in topoisomerase IIalpha protein expression renders the cell line resistant to ethonafide. The decrease in sensitivity to ethonafide was associated with a decrease in DNA damage and an increase in DNA repair as measured by the neutral comet assay. These data demonstrate that ethonafide is a topoisomerase II poison and that it is topoisomerase IIalpha-specific in the DU 145 human prostate cancer cell line. Uses: Topoisomerase ii inhibitors. Synonyms: AMP-53; AMP 53; AMP53; 2-(2'-(Dimethylamino)ethyl)-1,2-dihydro-7-ethoxydibenz(de, H)isoquinoline-1,3-dione; 2-[2-(Dimethylamino)ethyl]-7-ethoxy-1H-dibenz[de,h]isoquinoline-1,3(2H)-dione. CAS No. 175293-23-9. Molecular formula: C22H22N2O3. Mole weight: 362.43. | |
| Ethopropazine hydrochloride | Ethopropazine hydrochloride is an inhibitor of butyrylcholinesterase. It is a medication derived from phenothiazine. It could reduce extrapyramidal motor effects and used as an antidyskinetic to treat Parkinson's disease. It also alleviates thermal hyperalgesia in rats. It is sold under the trade names Parsidol in the United States and Parsidan in Canada. It was developed by Pfizer and has been listed. Uses: Ethopropazine hydrochloride is used as an antidyskinetic to treat parkinson's disease. Synonyms: 10-(2-(diethylamino)propyl)-phenothiazin monohydrochloride;Isothazine hydrochloride;Lysivane hydrochloride;10H-Phenothiazine-10-ethanamine,N,N-diethyl-a-methyl- hydrochloride (1:1);N,N-diethyl-1-phenothiazin-10-ylpropan-2-amine hydrochloride;Dibutil HCl;Pardisol HCl;Parfezin HCl;Profenamine HCl. Grades: >98%. CAS No. 1094-08-2. Molecular formula: C19H25ClN2S. Mole weight: 348.93. | |
| Ethyl 1-Thio-β-D-glucuronide | Ethyl 1-Thio-β-D-glucuronide is a compound useful in organic synthesis. Synonyms: Ethyl 1-Thio-β-D-glucopyranosiduronic Acid; Ethyl β-D-Thioglucopyranosiduronic Acid. CAS No. 117757-06-9. Molecular formula: C8H14O6S. Mole weight: 238.26. | |
| Ethyl 2,3,4,6-tetra-O-(4-methoxybenzyl)-b-D-thiogalactopyranoside | Ethyl 2,3,4,6-tetra-O-(4-methoxybenzyl)-b-D-thiogalactopyranoside is a remarkable biomedical compound, used for studying the signaling pathways of galactoside metabolism. Molecular formula: C40H48O9S. Mole weight: 704.87. | |
| Ethyl 2,3,4,6-tetra-O-(4-methoxybenzyl)-b-D-thiogalactopyranoside S-oxide | Ethyl 2,3,4,6-tetra-O-(4-methoxybenzyl)-b-D-thiogalactopyranoside S-oxide serves as a potentially groundbreaking pharmaceutical compound. Its multifaceted functionality lies in its ability to precisely target and manipulate intricate cell signaling pathways, ultimately bestowing it with the power to effectively study various diseases. Molecular formula: C40H48O10S. Mole weight: 720.87. | |
| Ethyl 2,3,4,6-tetra-O-(4-methoxybenzyl)-b-D-thioglucopyranoside | Ethyl 2,3,4,6-tetra-O-(4-methoxybenzyl)-b-D-thioglucopyranoside is a profoundly significant compound acting as a precursor. Its distinctive molecular configuration endows with substantial utility in the realms of research concerning afflictions including malignancy, diabetes mellitus and cardiovascular disorders. Molecular formula: C40H48O9S. Mole weight: 704.87. | |
| Ethyl 2,3,4,6-tetra-O-acetyl-a-D-thiogalactopyranoside | Ethyl 2,3,4,6-tetra-O-acetyl-α-D-thiogalactopyranoside is a substrate analog for beta-D-galactosidase, enabling the detection and study of enzyme kinetics. This versatile product is widely employed in the development and validation of novel drugs targeting lysosomal storage diseases, such as Gaucher's disease. Synonyms: Ethyl 2,3,4,6-Tetra-O-acetyl-alpha-D-thiogalactopyranoside; [(2R,3S,4S,5R,6R)-3,4,5-triacetyloxy-6-ethylsulfanyloxan-2-yl]methyl acetate; alpha-D-Galactopyranoside, ethyl 1-thio-, 2,3,4,6-tetraacetate; (2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-(ethylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate; [(2R,3S,4S,5R,6R)-3,4,5-TRIS(ACETYLOXY)-6-(ETHYLSULFANYL)OXAN-2-YL]METHYL ACETATE. CAS No. 126187-25-5. Molecular formula: C16H24O9S. Mole weight: 392.42. | |
| Ethyl 2,3,4,6-tetra-O-acetyl-b-D-galactopyranoside | Ethyl 2,3,4,6-tetra-O-acetyl-b-D-galactopyranoside is a precursor in the synthesis of galactosides, which are vital in drug development for researchs related to cancer, cardiovascular disorders and viral infections. Molecular formula: C16H24O10. Mole weight: 376.36. | |
| Ethyl 2,3,4,6-tetra-O-acetyl-b-D-thiogalactopyranoside | Ethyl 2,3,4,6-tetra-O-acetyl-β-D-thiogalactopyranoside, a fundamental compound in the field of biomedicine, assumes a pivotal role as a substrate in enzymatic assays, enabling the detection and quantification of substrates associated with lactose metabolism. Through its acetylated configuration, this compound significantly enhances the efficacy and precision of galactosidase activity evaluation. Synonyms: 1-S-Ethyl 2,3,4,6-tetra-O-acetyl-b-D-thiogalactopyranoside. CAS No. 55722-49-1. Molecular formula: C16H24O9S. Mole weight: 392.42. | |
| Ethyl 2,3,4,6-tetra-O-acetyl-D-thiomannopyranoside - min 80% a-anomer | Ethyl 2,3,4,6-tetra-O-acetyl-D-thiomannopyranoside, known for its a-anomer composition exceeding 80%, holds immense significance within the biomedical domain. Its application extensively revolves around the exploration of pharmacological characteristics and prospective therapeutic utilities of mannopyranosides. The compound's exceptional purity renders it an indispensable foundational component in the creation of pioneering drugs aimed at combating diverse ailments, encompassing viral afflictions and malignant tumors. Synonyms: ETHYL 2,3,4,6-TETRA-O-ACETYL-ALPHA-D-THIOMANNOPYRANOSIDE; [(2R,3R,4S,5S,6R)-3,4,5-Triacetyloxy-6-ethylsulfanyloxan-2-yl]methyl acetate; Ethyl 2,3,4,6-Tetra-O-acetyl-alpha-D-thiomannopyranoside(contains up to 20per cent beta isomer); Ethyl 2,3,4,6-Tetra-O-acetyl-a-D-thiomannopyranoside; SCHEMBL7152987; E87545; ethyl 2,3,4,6-tetra-o-acetyl-1-thio-alpha-d-mannopyranoside; Ethyl 2,3,4,6-tetra-O-acetyl-a-D-thiomannopyranoside(contains up to 20% beta isomer); Ethyl 2,3,4,6-Tetra-O-acetyl-alpha-D-thiomannopyranoside(contains up to 20% beta isomer). CAS No. 79389-52-9. Molecular formula: C16H24O9S. Mole weight: 392.42. | |
| Ethyl 2,3,4,6-tetra-O-benzoyl-b-D-thiogalactopyranoside | Ethyl 2,3,4,6-tetra-O-benzoyl-b-D-thiogalactopyranoside is a valuable compound acting as a crucial substrate for various enzymatic assays and biochemical research studies. It is specifically employed in the development and investigation of drug candidates targeting galactosyltransferase enzymes. Furthermore, this compound can be utilized as a synthetic intermediate in the synthesis of carbohydrate-based drugs for studying diseases such as cancer and infectious disorders. Synonyms: (2R,3S,4S,5R,6S)-2-((Benzoyloxy)methyl)-6-(ethylthio)tetrahydro-2H-pyran-3,4,5-triyl tribenzoate;Ethyl 2,3,4,6-tetra-O-benzoyl-1-thio-beta-D-galactopyranoside. CAS No. 138661-53-7. Molecular formula: C36H32O9S. Mole weight: 640.7. | |
| Ethyl 2,3,4,6-tetra-O-benzyl-b-D-galactopyranoside | |
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