BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| NSC 210902 | NSC 210902 is an ATP-competitive inhibitor of casein kinase 2 (CK2). It inhibits CK2 which is increased in tumor tissues, suppressing the proliferation of cancer cells. Synonyms: 4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylic acid. Grades: ≥95%. CAS No. 51726-83-1. Molecular formula: C14H9NO3. Mole weight: 239.2. |  |
| NSC232003 | NSC232003, a uracil derivative freely available by the NCI/DTP Repository, is an effective DNA methylation inhibitor. Synonyms: NSC232003; NSC 232003; NSC-232003; (5Z)-5-[1-(hydroxyamino)ethylidene]pyrimidine-2,4-dione. CAS No. 1905453-18-0. Molecular formula: C6H7N3O3. Mole weight: 169.14. | |
| NSC 625987 | NSC625987 is a cyclin-dependent kinase 4 inhibitor with IC50 of 0.2 μM at cdk4/cyclin D1. Synonyms: NSC 625987; NSC-625987; NSC625987; Cdk4 Inhibitor II. 1,4-Dimethoxy-9(10H)-acridinethione. Grades: ≥98% by HPLC. CAS No. 141992-47-4. Molecular formula: C15H13NO2S. Mole weight: 271.33. | |
| NSC697923 | NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity. Synonyms: NSC 697923; NSC-697923; Furan, 2-[(4-methylphenyl)sulfonyl]-5-nitro-; 2-Nitro-5-(toluene-4-sulfonyl)-furan. Grades: >98%. CAS No. 343351-67-7. Molecular formula: C11H9NO5S. Mole weight: 267.26. | |
| NSC87877 | NSC87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2 with IC50 values of 355nm and 318 nM, respectively. It shows effective growth inhibition and induction of apoptosis in NB cell lines. It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26. It blocks epidermal growth factor receptor-induced activation of Ras and ERK1/2 in HEK293 cells, stimulates store-operated calcium entry in response to thrombin in platelets, and increased acetylcholine receptor clustering in myotubes. Synonyms: NSC-87877; 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-; (E)-8-hydroxy-7-((6-sulfonaphthalen-2-yl)diazenyl)quinoline-5-sulfonic acid. Grades: >98 %. CAS No. 56990-57-9. Molecular formula: C19H13N3O7S2. Mole weight: 459.45. | |
| N-(Succinyl)-2-acetamido-2-deoxy-b-D-glucopyranosylhydroxylamine | N-(Succinyl)-2-acetamido-2-deoxy-b-D-glucopyranosylhydroxylamine is a biomedical wonder, emerging as a paramount tool in studying an array of illnesses such as bacterial infections. By selectively modulating disease-related enzymes and receptors, this extraordinary product has a promising biomedical prospect. Molecular formula: C12H18N2O8. Mole weight: 318.28. | |
| N-(Succinyl)-O-b-D-galactopyranosylhydroxylamine | N-(Succinyl)-O-b-D-galactopyranosylhydroxylamine is an exceptional biomedical substance, finding its application in the research of targeting explicit enzymes or pathways implicated in the advancement of diverse maladies, comprising cancer and inflammatory disorders. Molecular formula: C10H15NO8. Mole weight: 277.23. | |
| N-(Succinyl)-O-b-D-glucopyranosylhydroxylamine | | |
| N-(Succinyl)-O-b-D-lactosylhydroxylamine | | |
| N-(Succinyl)-O-b-D-maltosylhydroxylamine | | |
| N-Sulfo-glucosamine Potassium salt | N-Sulfo-glucosamine Potassium salt is a valuable biomedical product with potent anti-inflammatory properties used in the research of various diseases such as inflammatory disorders and joint diseases, including osteoarthritand rheumatoid arthritis. Synonyms: Potassium N-sulfoglucosamine; Potassium ((2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl)sulfamate; Potassium 2-deoxy-2-sulfoamino-D-glucose; Glucosamine N-sulfate potassium salt; BWD7N48R1I; D-Glucose, 2-deoxy-2-(sulfoamino)-, potassium salt (1:1); potassium; N-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]sulfamate; D-Glucose, 2-deoxy-2-(sulfoamino)-, monopotassium salt; UNII-BWD7N48R1I; C6H12KNO8S; glucosamine sulfate potassium; DTXSID80185203; AKOS016009807; AS-69554; CS-0158491; 38899-05-7; GLUCOSAMINE N-SULFATE POTASSIUM [WHO-DD]; A875974; Q27274928; Potassium((2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl)sulfamate; POTASSIUM (2R,3R,4S,5R)-3,4,5,6-TETRAHYDROXY-2-(SULFONATOAMINO)HEXANAL; 2-Deoxy-2-sulfoamino-D-glucose potassium salt; 2-Deoxy-2-(sulfoamino)-D-glucose monopotassium salt; D-Glucose, 2-deoxy-2-(sulfoamino)-, monopotassium salt (8CI,9CI); Potassium 2-deoxy-2-sulfoamino-D-glucose. CAS No. 31284-96-5. Molecular formula: C6H12KNO8S. Mole weight: 297.33. | |
| N-Thioglycolyl-D-galactosamine | N-Thioglycolyl-D-galactosamine is a key compound used in the biomedical industry for the synthesis of glycan derivatives. It is predominantly employed in the development of targeted drug delivery systems, specifically for the research of liver diseases and cancers. This product aids in the attachment of compounds to galactosamine receptors. Synonyms: GalNTGc. CAS No. 1334320-74-9. Molecular formula: C8H15NO6S. Mole weight: 253.27. | |
| N-(trans-3-Hydroxycotinine)-b-D-glucuronide methyl-D3 | N-(trans-3-Hydroxycotinine)-b-D-glucuronide methyl-D3 is a valuable tool in biomedical research for studying nicotine addiction and metabolism. It is a stable isotope-labeled internal standard used in LC-MS/MS analysis for quantifying trans-3'-hydroxycotinine glucuronide levels in biological samples. This compound aids in understanding the pharmacokinetics and pharmacodynamics of nicotine, developing strategies for studying nicotine addiction-related diseases. Molecular formula: C16H17D3N2O8. Mole weight: 371.36. | |
| N-(Trifluoroacetyl)-1-desmethyl daunorubicin | N-(Trifluoroacetyl)-1-desmethyl Daunorubicin is a derivative of Daunorubicin, which is an anthracycline antibiotic used in the treatment of acute myeloid and lymphocytic leukemia, with adverse reactions such as cardiotoxicity and bone marrow suppression. Synonyms: (8S-cis)-8-Acetyl-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-10-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione; (8S,10S)-8-acetyl-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-10-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione; (1S,3S)-3-Acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-lyxo-hexopyranoside. Grades: ≥95%. CAS No. 68594-06-9. Molecular formula: C28H26F3NO11. Mole weight: 609.50. | |
| NU1025 | NU1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1025 enhanced the cytotoxicity of the DNA-methylating agent MTIC, gamma-irradiation and bleomycin 3.5-, 1.4- and 2-fold respectively. Synonyms: NU-1025; NU 1025; 8-Hydroxy-2-methylquinazoline-4-one; NSC 696807. Grades: ≥98%. CAS No. 90417-38-2. Molecular formula: C9H8N2O2. Mole weight: 176.17. | |
| NU1064 | NU1064 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which can potentiate the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1064 potentiated a sublethal concentration of a DNA methylating agent in a concentration-dependent manner. Synonyms: NU-1064; NU 1064; 4-Piperidinol, 1-butyl-4-(2-pyridyl)methyl-, acetate, dihydrochloride. Grades: 98%. CAS No. 63916-38-1. Molecular formula: C9H9N3O. Mole weight: 175.19. | |
| NU1085 | NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. It has been developed to potentiate the cytotoxicity of ionizing radiation and anticancer drugs. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: NU-1085; NU 1085; 2-(4-hydroxyphenyl)-1H-benzo[d]imidazole-7-carboxamide. Grades: 98%. CAS No. 188106-83-4. Molecular formula: C14H11N3O2. Mole weight: 253.26. | |
| NU6027 | NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. NU6027 attenuated G2/M arrest following DNA damage, inhibited RAD51 focus formation and increased the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy but not the antimitotic, paclitaxel. In A2780 cells sensitisation to cisplatin was greatest in cells with functional p53 and mismatch repair (MMR) and sensitisation to temozolomide was greatest in p53 mutant cells with functional MMR. Importantly, NU6027 was synthetically lethal when DNA single-strand break repair is impaired either through poly(ADP-ribose) polymerase (PARP) inhibition or defects in XRCC1. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and PARP inhibitors. It provides proof of concept data for clinical development of ATR inhibitors. Synonyms: NU-6027; NU 6027; 2,6-Diamino-4-(cyclohexylmethoxy)-5-nitrosopyrimidine; 6-(Cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine; 4-Cyclohexylmethoxy-2,6-diamino-5-nitrosopyrimidine; 4-Cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine. Grades: ≥98%. CAS No. 220036-08-8. Molecular formula: C11H17N5O2. Mole weight: 251.29. | |
| NU6140 | NU6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor, and induces cell-cycle arrest at the G2-M phase. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively. Synonyms: Cdk2 inhibitor IV; NU 6140. Grades: 98%. CAS No. 444723-13-1. Molecular formula: C23H30N6O2. Mole weight: 422.53. | |
| NU7026 | NU7026 is a potent DNA-PK inhibitor with IC50 value of 0.23±0.01 μM. NU7026 has been described to increase precise genome-editing efficiency in pluripotent stem cells. Synonyms: DNA-PK Inhibitor II; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one; 2-morpholin-4-ylbenzo[h]chromen-4-one. Grades: >98%. CAS No. 154447-35-5. Molecular formula: C17H15NO3. Mole weight: 281.311. | |
| NU-7031 | NU-7031 is a potent DNA-PK inhibitor with potential anticancer activity. Synonyms: NU7031; NU 7031. Grades: 98%. CAS No. 79105-88-7. Molecular formula: C14H15NO4. Mole weight: 261.28. | |
| NU-7107 | NU-7107 is a potent DNA-PK inhibitor with potential anticancer activity. Synonyms: NU 7107; NU7107. Grades: 98%. CAS No. 503465-21-2. Molecular formula: C18H19N3O2. Mole weight: 309.36. | |
| NU-7199 | NU-7199 is a potent DNA-PK inhibitor with potential anticancer activity. Synonyms: NU 7199; NU7199. Grades: 98%. CAS No. 69541-04-4. Molecular formula: C17H17NO4. Mole weight: 299.33. | |
| NU-7200 | NU-7200 is a potent DNA-PK inhibitor with potential anticancer activity. Synonyms: NU 7200; NU7200. Grades: 98%. CAS No. 842122-14-9. Molecular formula: C17H17NO4. Mole weight: 299.326. | |
| nusinersen | Nusinersen is a drug used for the treatment of spinal muscular atrophy (SMA), which is related to the mutation in the SMN1 gene. It was approved by FDA in Dec. 2016 for the treatment of SMA in adults and children. Uses: The treatment of sma. Synonyms: RNA [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G); Spinraza; ISIS 396443; 1: PN: WO2010148249 SEQID: 1 claimed DNA. Grades: ≥95%. CAS No. 1258984-36-9. Molecular formula: C234H340N61O128P17S17. Mole weight: 7127.18. | |
| NV-128 | NV-128 is a novel isoflavone derivative, which has been shown in pre-clinical studies to promote cancer cell death in multi drug resistant cancer cells by inducing caspase-independent DNA degradation and cancer cell death via the AKT-mTOR pathway. In contrast to phenoxodiol and triphendiol, NV-128 has been shown to induce caspase-independent DNA degradation and cancer cell death. It appears that in conjunction with autophagy induction, NV-128 induces caspase independent cell death via the AKT-mTOR pathway resulting in beclin sequestration of Bcl-2, Bax up-regulation and mitochondrial depolarization. As a consequence, endonuclease G translocates to the nucleus where it initiates DNA degradation and cell death. This offers an opportunity for use as a monotherapy in chemoresistant cancers and enhanced efficacy against cancer targets less susceptible to phenoxodiol. The option for co-administration of combinations of these drugs is also under investigation to extend the potential therapeutic range of this unique class of oncology compounds. Synonyms: NV-128; NV 128; NV128. CAS No. 1210335-22-0. | |
| N-Valeryl-D-glucosamine | N-Valeryl-D-glucosamine, an imperative compound widely employed in the biomedical sector, is esteemed for its tremendous prospects in the pharmaceutical arena. Its significance lies in the development of therapeutic agents targeting diverse ailments encompassing inflammation and autoimmune disorders. Synonyms: N-Valeryl-D-glucosamine; 63223-57-4; N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]pentanamide; SCHEMBL5157878; N-N-VALERYL-D-GLUCOSAMILE; MFCD00059805; 2-Deoxy-2-valeramido-D-glucopyranose; 2-Deoxy-2-pentanamido-D-glucopyranose; V0011; T72746; W-203351; N-((3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)pentanamide. CAS No. 63223-57-4. Molecular formula: C11H21NO6. Mole weight: 263.29. | |
| N-Valinyl-1-deoxy-D-glucitol | N-Valinyl-1-deoxy-D-glucitol is an exceptional biomedical compound, demonstrating remarkable potential in the research for diabetes. It serves as a potent α-glucosidase inhibitor. Synonyms: N-Glucosyl-L-valine. Molecular formula: C11H23NO7. Mole weight: 281.30. | |
| NVP-QAV680 | NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM by 3H-PGD2 filtration binding assay. Synonyms: QAV-690 free acid; QAV690 free acid; QAV 690 free acid; NVP-QAV680; NVP ; NVPQAV680; NVP-QAV-680. Grades: >98%. CAS No. 872365-16-7. Molecular formula: C18H18N2O4S. Mole weight: 358.41. | |
| O-(2,3,4,6-Tetra-O-acetyl-b-D-galactopyranosyl)-N-hydroxysuccinimide | O-(2,3,4,6-Tetra-O-acetyl-b-D-galactopyranosyl)-N-hydroxysuccinimide is a coupling compound for the efficient labeling of bioactive molecules or peptides with carbohydrates. This versatile product facilitates the synthesis of glycoconjugates. Molecular formula: C18H23NO12. Mole weight: 445.37. | |
| O-(2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl)-N-hydroxysuccinimide | O-(2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl)-N-hydroxysuccinimide is a compound renowned for its pivotal role in pharmaceutical research and drug development. This compound reigns supreme as a catalyst for glycoside and glycoprotein synthesis, enabling the research of multifarious ailments including cancer, diabetes and inflammation. Molecular formula: C18H23NO12. Mole weight: 445.37. | |
| O-(2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-D-glucopyranosylidene)amino N-(4-nitrophenyl)carbamate | O-(2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-D-glucopyranosylidene)amino N-(4-nitrophenyl)carbamate, a compound of significant biomedical importance, stands out as a potent therapeutic agent in tackling an array of diseases. Notably, its exceptional antiviral activity renders it particularly effective against RNA viruses. Furthermore, by selectively targeting precise signaling pathways, this compound exhibits substantial potential in curtailing the proliferation of specific cancer cells. Synonyms: 2-(Acetylamino)-2-deoxy-N-[[[(4-nitrophenyl)amino]carbonyl]oxy]-D-gluconimidic acid 3,4,6-triacetate ?-lactone. CAS No. 351421-19-7. Molecular formula: C21H24N4O12. Mole weight: 524.44. | |
| O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranosyl)-N-hydroxysuccinimide | O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranosyl)-N-hydroxysuccinimide is a pivotal and indispensable compound within the realms of the biomedical industry assuming a paramount role in the synthesis of an array of pharmacological substances and bioconjugates. Molecular formula: C18H23NO12. Mole weight: 445.37. | |
| O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-D-glucopyranosylidene)amino N-(4-nitrophenyl)carbamate | O-(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-D-glucopyranosylidene)amino N-(4-nitrophenyl)carbamate is a highly intricate compound widely utilized in the extensive realm of the biomedical sector, facilitating pioneering advancements in the spheres of drug development and disease elucidation. Molecular formula: C21H23N3O12. Mole weight: 509.42. | |
| O-(2-Acetamido-3,4,6-tri-O-acetyl-D-glucopyranosylidene)amino N-phenyl carbamate | O-(2-Acetamido-3,4,6-tri-O-acetyl-D-glucopyranosylidene)amino N-phenyl carbamate is a pivotal element, finding its application in research of cancer, neurodegenerative disorders and microbial infections by exerting inhibitory effects on associated enzymes. Synonyms: 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-N-[(phenylaminocarbonyl)oxy]-D-gluconimidic acid-1,5-lactone. CAS No. 132063-04-8. Molecular formula: C21H25N3O10. Mole weight: 479.44. | |
| O6-Benzylguanine | O6-Benzylguanine is a guanine derivative that acts as an irreversible inhibitor of O6-Alkylguanine-DNA alkyltransferase (AGT; MGMT), a DNA repair protein. It inactivates AGT and increases the chemotherapeutic effectiveness of chloroethylating and methylating agents in vitro and in human tumor xenograft models. Uses: An irreversible inhibitor of the mammalian dna repair protein, o6-alkylguanine-dna alkyltransferase. assists in the protection against carcinogenic and therapeutic alkylating agents. Synonyms: 6-phenylmethoxy-7H-purin-2-amine; 6-phenylmethoxy-7H-purin-2-amine. Grades: ≥ 98 %. CAS No. 19916-73-5. Molecular formula: C12H11N5O. Mole weight: 241.25. | |
| OAC1 | OAC1 is an octamer-binding transcription factor 4 (Oct4) activator. It enhances reprogramming efficiency of iPSC and accelerates the reprogramming process. Synonyms: BAS 00287861; OAC-1; N-1H-pyrrolo[2,3-c]pyridin-5-ylbenzamide. Grades: >98%. CAS No. 300586-90-7. Molecular formula: C14H11N3O. Mole weight: 237.26. | |
| O-Acetyl Salicylhydroxamic Acid | An irreversible, non-selective inhibitor of COX-1 and COX-2. Synonyms: N-(acetyloxy)-2-hydroxy benzamide; AcSHA; O-ASHA. CAS No. 199854-00-7. Molecular formula: C9H9NO4. Mole weight: 195.2. | |
| O-a-D-Mannopyranosyl L-threonine | O-a-D-Mannopyranosyl L-threonine is an indispensable biomedical compound, aiding in studying diabetes. Its remarkable prowess lies in its unparalleled ability to enhance insulin sensitivity and expedite glucose utilization, enshrining it as an efficacious implement for the comprehensive research of diabetes mellitus. Molecular formula: C10H19NO8. Mole weight: 281.26. | |
| OAT-889 | OAT-889 is a dual inhibitor of acidic mammalian chitinase (AMCase) and chitotriosidase-1 (CHIT1) (hAMCase IC50 = 9 nM;hCHIT1 IC50 = 26 nM), which has the potential to treat asthma. OAT-889 reduced the number of infiltrating leukocytes in bronchoalveolar lavage fluid (BALF) in an acute mouse model of lung inflammation, as well as decreased mRNA of proinflammatory cytokines, such as interleukin-13, interleukin-1 and Muc5AC in lung tissue. Uses: The treatment of asthma. Synonyms: OAT 889; OAT889. | |
| obiltoxaximab | Obiltoxaximab is a monoclonal antibody developed for the treatment of exposure to Bacillus anthracis spores. It may cause allergic reactions, including anaphylaxis. Uses: The treatment of exposure to bacillus anthracis spores. Synonyms: Anthim. CAS No. 1351337-07-9. Molecular formula: C6444H9994N1734O2022S44. Mole weight: 145500. | |
| Obinutuzumab | Obinutuzumab is a humanized monoclonal antibody that inhibits CD20 for cancer therapy. In combination with chlorambucil, it was approved as a first-line treatment for chronic lymphocytic leukemia. It also can be used to treat follicular lymphoma. Uses: The treatment of chronic lymphocytic leukemia. Synonyms: GA101; GA 101; GA-101. CAS No. 949142-50-2. Molecular formula: C6512H10060N1712O2020S44. Mole weight: 146100. | |
| OBP-801 | OBP-801, also known YM753 and spiruchostatin A, is a novel cyclic-peptide-based HDAC inhibitor. YM753 is a bacteria-derived natural product containing a disulfide bond. It potently inhibited HDAC enzyme with an IC50 of 2.0 nM in the presence of dithiothreitol. YM753 was rapidly converted to a reduced form in tumor cells, and then induced accumulation of acetylated histones, followed by p21WAF1/Cip1 expression, tumor cell growth inhibition and tumor-selective cell death. In an in vitro washout study, YM753 showed prolonged accumulation of acetylated histones in WiDr human colon carcinoma cells. In vivo YM753 dosing of mice harboring WiDr colon tumor xenografts significantly inhibited the tumor growth via sustained accumulation of acetylated histones in the tumor tissue. In a pharmacokinetic study, YM753 rapidly disappeared from the plasma, but its reduced form remained in the tumor tissue. Moreover, the accumulation of acetylated histones induced by YM753 was tumor tissue selective compared to several normal tissues. YM753 has attractive pharmacodynamic and pharmacokinetic properties giving it potential as an antitumor agent. Synonyms: OBP 801; OBP801; spiruchostatin A; YM-753; YM 753; (1S,5S,6R,9S,20R,E)-5-hydroxy-6-isopropyl-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetraone. Grades: >98%. CAS No. 328548-11-4. Molecular formula: C20H31N3O6S2. Mole weight: 473.60. | |
| O-Butanoyl-2,3-O-isopropylidene-a-D-mannofuranoside | O-Butanoyl-2,3-O-isopropylidene-a-D-mannofuranoside is a carbohydrate-based compound, finding application in the research of mannofuranosides in intricate biological networks. Molecular formula: C14H26O7. Mole weight: 304.38. | |
| ocrelizumab | Ocrelizumab is an anti-CD20 monoclonal antibody developed by Genentech to treat relapsing and primary progressive forms of multiple sclerosis (MS). Uses: The treatment of relapsing and primary progressive forms of multiple sclerosis (ms). Synonyms: Ocrevus. CAS No. 637334-45-3. Molecular formula: C6494H9978N1718O2014S46. Mole weight: 148000. | |
| Octanoyl b-D-glucosylamine | Octanoyl b-D-glucosylamine is a biomedical product used to treat insulin resistance, a condition commonly associated with type 2 diabetes. This compound, derived from glucose, has potential therapeutic effects in regulating blood glucose levels and improving insulin sensitivity. Synonyms: N-(b-D-Glucopyranosyl)octanamide. CAS No. 134403-86-4. Molecular formula: C14H27NO6. Mole weight: 305.37. | |
| OctMAB | OctMAB is a dynamin inhibitor with IC50 value of 1.9 μM for dynamin I. It can also inhibit receptor-mediated endocytosis. Synonyms: Octadecyltrimethylammonium bromide. Grades: ≥95%. CAS No. 1120-02-1. Molecular formula: C21H46BrN. Mole weight: 392.5. | |
| Octyl 3,4,6-tri-O-benzoyl-a-D-mannopyranoside | Octyl 3,4,6-tri-O-benzoyl-a-D-mannopyranoside is a biomedical product employed as a substrate analog to assess enzymatic specificity and selectivity towards carbohydrates. Octyl 3,4,6-tri-O-benzoyl-a-D-mannopyranoside finds applications in investigating glycosidase enzymes involved in diseases such as cancer and lysosomal storage disorders. Molecular formula: C35H40O9. Mole weight: 604.69. | |
| Octyl 4-O-acetyl-2,3-O-isopropylidene-a-L-rhamnopyranoside | Octyl 4-O-acetyl-2,3-O-isopropylidene-a-L-rhamnopyranoside is a chemical compound renowned for its multifaceted applications in drug formulation and cutting-edge research for the research and development of diverse drugs tailored to study specific diseases. Molecular formula: C19H34O6. Mole weight: 358.47. | |
| Octyl b-D-glucuronic acid | Octyl b-D-glucuronic acid is an intricate and bioactive compound, used for the research of hepatic afflictions. Molecular formula: C14H26O7. Mole weight: 306.36. | |
| Octyl D-glucuronic acid | Octyl D-glucuronic acid is a promising compound, emerging as a prodigious solution for studying liver ailments and drug detoxification. Molecular formula: C14H26O7. Mole weight: 306.36. | |
| Octyl L-glucopyranoside | Octyl L-glucopyranoside is a multifunctional and highly versatile bioactive compound, finding extensive applications in protein purification, membrane protein solubilization and lipid bilayer stabilization. It facilitates the solubilization and stabilization of drugs research specifically designed to target membrane proteins, infectious diseases and neurological disorders. Molecular formula: C14H28O6. Mole weight: 292.37. | |
| O-Desmethyl-N,N-desmethyl-venlafaxine D-gluronide | | |
| O-Desmethyl Venlafaxine Glucuronide (Mixture of Isomers) | O-Desmethyl Venlafaxine Glucuronide is a metabolite of Venlafaxine. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that is used as an antidepressant. According to different doses, it effects on serotonergic transmission, noradrenergic systems and dopaminergic neurotransmission. Venlafaxine is commonly used to treat depression, general anxiety disorder, social phobia, panic disorder, and vasomotor symptoms. Synonyms: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol glucuronide; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenylb-D-glucopyranosiduronic acid. CAS No. 1021933-98-1. Molecular formula: C22H33NO8. Mole weight: 439.50. | |
| O-(D-Glucopyranosylidene)amino N-phenylcarbamate | O-(D-Glucopyranosylidene)amino N-phenylcarbamate is a potential compound aiding in the research of various diseases such as cancers, infectious diseases and autoimmune disorders. Synonyms: PUGLU. CAS No. 104012-84-2. Molecular formula: C13H16N2O7. Mole weight: 312.28. | |
| ODM-208 | ODM-208 is a novel and potent inhibitor of CYP11A1 which is pomisingly to be used to treat castration-resistant prostate cancer (CRPC). Studies in mouse model indicated that ODM-208 significantly suppressed the growth of tumor. Uses: The potential treatment of castration-resistant prostate cancer (crpc). Synonyms: ODM 208; ODM208. | |
| Odronextamab | Odronextamab is a human bispecific antibody that binds CD3 on T cells and CD20 on B cells. Odronextamab has been used in patients with relapsed or refractory B-cell non-Hodgkin lymphoma. CAS No. 1801338-64-6. | |
| O-Ethyl S-[methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-b-D-glycero-a-D-galacto-2-nonulopyranoside)onate] dithiocarbonate | | |
| Ofatumumab | Ofatumumab is a CD20-directed cytolytic monoclonal antibody with an inhibitory effect on early-stage B lymphocyte. It was approved by FDA for its use to treat patients with chronic lymphocytic leukemia (CLL) as an extended treatment or in combination with chlorambucil. It also has the thearapeutic effect on some other diseases such as follicular lymphoma. Uses: The treatment of chronic lymphocytic leukemia (cll). CAS No. 679818-59-8. Molecular formula: C6480H10022N1742O2020S44. Mole weight: 146100. | |
| OG-L002 | OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50s of ~10 μM and ~3 μM, respectively. OG-L002 is a potent and highly selective inhibitor of LSD1 (IC50 = 0.02 μM), and is a potent inhibitor of monoamine oxidases (MAO) with IC50s of 1.38 and 0.72 μM for MAO-A and MAO-B, respectively. Synonyms: 4'-[(1R,2S)-2-Aminocyclopropyl]-[1,1'-biphenyl]-3-ol; 4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol; [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-; 4'-[(1R,2S)-2-Aminocyclopropyl]-3-biphenylol. Grades: >98%. CAS No. 1357302-64-7. Molecular formula: C15H15NO. Mole weight: 225.29. | |
| Oglufanide disodium | Oglufanide disodium is the disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections. Synonyms: NSC 334073; NSC334073; NSC-334073; Oglufanide; Thymogen; Timogen; IM 862;IM862; IM-862. CAS No. 122933-59-9. Molecular formula: C16H19N3O5. Mole weight: 333.34. | |
| OGT2378 | OGT2378 is a GCS inhibitor (Glucosyl Ceramide Synthase Inhibitor) with potential anticancer activity. In murine models with melanoma, OGT2378 decreased tumor size, and showed no cytotoxic and apoptotic effects on MEB-4 melanomacells. Additionally, it has been reported that OGT2378 is biologically active, and a well tolerated agent in in vivo system. Synonyms: OGT-2378; OGT 2378; Sinbaglustat; N-Pentyl-L-ido-1-deoxynojirimycin; (2S,3R,4R,5S)-2-(Hydroxymethyl)-1-pentyl-3,4,5-piperidinetriol. Grades: 98%. CAS No. 441061-33-2. Molecular formula: C11H23NO4. Mole weight: 233.30. | |
| OHR-3031 | OHR-3031 is an anti-angiogenesis agent that is commonly used in the treatment of eye disorders, such as age-related macular degeneration. Uses: The treatment of age-related macular degeneration. Synonyms: OHR 3031; OHR3031. | |
| OK-1035 | OK-1035 is a potent and selective DNA-PK inhibitor. When a synthetic peptide was used as a substrate, OK-1035 caused 50% inhibition of DNA-PK activity at 8 microM. OK-1035 inhibited the phosphorylation by DNA-PK of consensus peptide as well as that of recombinant human wild type-p53. Kinetic studies indicated that OK-1035 inhibited DNA-PK activity in an ATP-competitive manner. Synonyms: OK1035; OK 1035. Grades: 98%. CAS No. 98293-88-0. Molecular formula: C12H9N5O. Mole weight: 239.23. | |
| Olanzapine 4-N-glucuronide | | |
| olaratumab | Olaratumab is a monoclonal antibody used for the treatment of solid tumors. In combination with doxorubicin, it can be used for the treatment of adults with advanced soft-tissue sarcoma (STS) who cannot be cured by cancer surgery or radiation therapy. Uses: The treatment of solid tumors. CAS No. 1024603-93-7. Molecular formula: C6554H10076N1736O2048S40. Mole weight: 147200. | |
| Olcegepant hydrochloride | Olcegepant hydrochloride is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with 150-fold selective over the peptidic antagonist CGRP8-37 (IC50 = 0.03 nM, Ki = 14.4 pM for human CGRP). Synonyms: N-[(2R)-1-[[(2S)-6-amino-1-oxo-1-(4-pyridin-4-ylpiperazin-1-yl)hexan-2-yl]amino]-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide;hydrochloride; Olcegepant (hydrochloride); Olcegepant hydrochloride. CAS No. 586368-06-1. Molecular formula: C38H47Br2N9O5.HCl. Mole weight: 906.11. | |
| Oleclumab | Oleclumab is a humanized anti-CD73 monoclonal antibody with antineoplastic activity. Synonyms: MEDI9447. CAS No. 1803176-05-7. | |
| Olmesartan N1-Glucuronide | Olmesartan N1-Glucuronide, a metabolite of Olmesartan, is an angiotensin II receptor antagonist. It could be used as an anti-hypertensive. Molecular formula: C30H34N6O9. Mole weight: 622.63. | |
| Olmesartan N2-Glucuronide | A metabolite of Olmesartan, which is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect. hAT1 receptors: IC50=6.7 nM. Synonyms: Olmesartan N2-Glucuronide. Grades: > 95%. Molecular formula: C30H34N6O9. Mole weight: 622.63. | |
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