BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Olokizumab | Olokizumab is a humanized monoclonal antibody that targets interleukin-6. Olokizumab is effective in the treatment of rheumatoid arthritis. Synonyms: CDP 6038; OKZ. CAS No. 1007223-17-7. |  |
| Olomoucine | Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2. Uses: Enzyme inhibitors. Synonyms: N2-[(2-Hydroxyethyl)-N6-benzyladenine; 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine; NSC 666096; 2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine; 2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol; 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine. Grades: ≥98%. CAS No. 101622-51-9. Molecular formula: C15H18N6O. Mole weight: 298.35. | |
| OM-137 | OM137 is an inhibitor of Aurora kinases. which is growth inhibitory to cultured cells when applied at high concentration and potentiates the growth inhibitory effects of subnanomolar concentrations of paclitaxel. Synonyms: OM137; OM 137; 2-Amino-N'-(4-hydroxy-3-methoxybenzylidene)-4-methylthiazole-5-carbohydrazide. CAS No. 292170-13-9. Molecular formula: C13H14N4O3S. Mole weight: 306.34. | |
| Omaciclovir | This active molecular is a DNA-directed DNA polymerase inhibitor potentially originated by Medivir AB. Omaciclovir can be selectively phosphorylated by viral thymidine kinase to its monophosphate form and it is further modified to a triphosphate, which is an inhibitor of VZV DNA polymerase. Preclinical trials for Herpes simplex virus infections, HIV infections and Varicella zoster virus infections were discontinued. Uses: Herpes simplex virus infections, hiv infections and varicella zoster virus infections. Synonyms: ABT-091; ABT091; ABT 091; H2G; H 2G; (-)-2HM-HBG; A-182091; 2HMHBG; Omaciclovir; 2-HMHBG; UNII-C9H909GLI3; Omaciclovir [USAN:INN]; C9H909GLI3; H 2G;2-amino-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-3H-purin-6-one. Grades: 98%. CAS No. 124265-89-0. Molecular formula: C10H15N5O3. Mole weight: 253.26. | |
| OMALIZUMAB | Omalizumab is a recombinant humanized monoclonal antibody against human immunoglobulin E (IgE). Synonyms: OMALIZUMAB. Grades: 95%. CAS No. 242138-07-4. Molecular formula: C48H80O4. | |
| Ombrabulin | Ombrabulin is a synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. Synonyms: AVE8062; AVE 8062; AC-7700; AC 7700; AC7700; CS-39-L-Ser.HCl; AVE-8062A; AVE-8062; RPR-258062A; RPR 258062A. CAS No. 181816-48-8. Molecular formula: C21H26N2O6. Mole weight: 402.45. | |
| Omburtamab | Omburtamab is a radiolabeled monoclonal antibody 8H9 (131I-8H9) developed to target B7-H3-expressing cells in solid tumors. CAS No. 1895083-75-6. | |
| o-Methoxytopolin-9-glucoside | o-Methoxytopolin-9-glucoside is a remarkable and efficacious compound, demonstrating remarkable anti-inflammatory and antioxidant capacities and emerging as an optimal choice to study afflictions stemming from oxidative stress, such as cancer, diabetes and neurodegenerative disorders. Synonyms: [6-(2-Methoxybenzylamino)-9-b-Dglucopyranosylpurine. CAS No. 1226978-27-7. Molecular formula: C19H23N5O6. Mole weight: 417.42. | |
| Ondansetron 6-D-glucuronide (mixture of isomers) | | |
| Ondansetron 7-D-glucuronide (mixture of isomers) | Cas No. 126671-74-7. | |
| ONO-2050297 | ONO-2050297, a benzooxazine derivative, has been found to be a CysLT1 as well as CysLT2 antagonist that could probably be effective in asthma researches. Synonyms: ONO-2050297; ONO 2050297; ONO2050297; (S)-4-(3-carboxypropyl)-8-(4-(4-phenylbutoxy)benzamido)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid. Grades: 98%. CAS No. 1637756-67-2. Molecular formula: C30H32N2O7. Mole weight: 532.59. | |
| ONO-2170573 | ONO-2170573 is a dual inhibitor of Axl/Mer tyrosine kinase receptor (Axl IC50 = 0.001 mcM, Mer IC50 = 0.0007 mcM). Synonyms: ONO 2170573; ONO2170573. | |
| ONO-6990554 | ONO-6990554 is a dual inhibitor of Axl/Mer tyrosine kinase receptor (Axl/Mer IC50 = 0.002 mcM). Synonyms: ONO6990554; ONO 6990554. | |
| ONO-9270578 | ONO-9270578 is a novel TRPC4/5 inhibitor. TRPC4 and TRC5 are both associated with modulation of anxiety and fear responses, thus ONO-9270578 has the anxiolytic effect. ONO-9270578 is the potential treatment of anxiety and depression. Uses: The potential treatment of anxiety and depression. Synonyms: ONO 9270578; ONO9270578. | |
| ONT-093 | ONT-093 (formerly OC-144-093) is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics. Phase I trials of ONT-093 in normal human volunteers showed no dose-limiting toxicities at serum concentrations associated with biologic activity achieved with doses ranging from 300 to 500 mg. Synonyms: ONT 093; ONT093; (E)-4,4'-(2-(4-(3-ethoxyprop-1-en-1-yl)phenyl)-1H-imidazole-4,5-diyl)bis(N-isopropylaniline). CAS No. 216227-54-2. Molecular formula: C32H38N4O. Mole weight: 494.68. | |
| Onvatilimab | Onvatilimab is a human monoclonal antibody that targets VISTA (V-domain immunoglobulin suppressor of T-cell activation). Onvatilimab inhibits VISTA signaling, abrogates the VISTA-induced suppression of T-lymphocyte-mediated immune responses, enhances cytotoxic T-cell responses against tumor cells and inhibits tumor cell growth. Synonyms: JNJ-61610588; JNJ 61610588; JNJ61610588. CAS No. 1969313-51-6. | |
| Org 24598 | Org 24598 is a glial glycine transporter inhibitor with IC50 value of 6.9 nM. Synonyms: Org 24598; Org24598; Org-24598; N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine. Grades: ≥98% by HPLC. CAS No. 372198-97-5. Molecular formula: C19H20F3NO3. Mole weight: 367.36. | |
| Org 24598 lithium salt | Org 24598 lithium salt is a glycine transporter-1 (GlyT-1) inhibitor with pIC50 value of 6.9 for GlyT1. Synonyms: Org 24598 lithium salt; Org24598 lithium salt; Org-24598 lithium salt; N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine lithium salt. Grades: ≥98% by HPLC. CAS No. 722456-08-8. Molecular formula: C19H19F3LiNO3. Mole weight: 373.3. | |
| ORG 25935 hydrochloride | ORG 25935 hydrochloride is a potent and selective glycine transporter 1 (GlyT-1) or reuptake inhibitor intended for the treatment of neurological disorders such as schizophrenia. Uses: Treatment of neurological disorders. Synonyms: SCH-900435; SCH 900435; SCH900435; ORG 25935 hydrochloride; ORG25935 hydrochloride; ORG-25935 hydrochloride; rel-N-Methyl-N-[[(1R,2S)-1,2,3,4-tetrahydro-6-methoxy-1-phenyl-2-naphthalenyl]methyl]glycine hydrochloride. Grades: 99%. CAS No. 949588-40-3. Molecular formula: C21H25NO3.HCl. Mole weight: 375.89. | |
| Org30958 | ORG 30958 is a potent aromatase inhibitor in vivo. ORG 30958 proved to be devoid of antiestrogenic activity which indicates that the absence of cornification of vaginal epithelium in DHEAS-treated Hypex rats is induced by the inhibition of the biosynthesis of estrogens and not by an anti-estrogenic activity. Synonyms: (8S,9S,10S,13S,14S)-10-[(ethyldisulfanyl)methyl]-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione; 19-(ethyldithio)androst-4-ene-3,17-dione; ORG 30958; ORG-30958. CAS No. 99957-90-1. Molecular formula: C21H30O2S2. Mole weight: 378.59. | |
| Ormaplatin | Ormaplatin is a platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. Synonyms: Ormaplatine; Ormaplatino; Tetraplatin(IV); U 77,233; U-77,233; (+-)-trans-Tetrachloro(1,2-cyclohexanediamine)platinum. CAS No. 62816-98-2. Molecular formula: C6H14Cl4N2Pt. Mole weight: 451.08. | |
| Oroxylin A 7-O-glucuronide | Oroxylin A 7-O-glucuronide is a highly valuable constituent harnessed in the biomedical sector, showcasing profound anti-inflammatory and antitumor attributes in studying cancer and maladies linked to inflammation. Uses: Antioxidant. Synonyms: Oroxyloside. Grades: >98%. CAS No. 36948-76-2. Molecular formula: C22H20O11. Mole weight: 460.39. | |
| Ortataxel | Ortataxel, also known as IDN5109, is novel seimsynthetic taxane with potential anticancer activity. Ortataxel is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. In in vitro experiments, IDN5109 showed antiproliferative effects against HNSCC cell lines. After treatment with IDN5109, Bcl-2 and Bcl-XL were down-regulated, Bax was up-regulated, and caspase-3 was activated. After treatment with IDN5109, concentrations of both VEGF and IL-8 in the culture supernatant of HNSCC cells decreased. In in vivo experiments, the oral administration of IDN5109 showed antitumor effects against HNSCC tumor xenografts. Immunohistochemistry showed that IDN5109 inhibited tumor angiogenesis and induced apoptosis in HNSCC cells, producing a decreased blood vessel density and increased apoptosis index. On the basis of these results, IDN5109 is useful as a chemotherapeutic agent against HNSCC. Uses: Antineoplastic agents. Synonyms: Bay-59-8862, Bay 59 8862; SB-T-101131; SB T 101131; 13-(N-tert-butoxycarbonyl-beta-isobutyisoserinyl)-14-hydroxy-baccatin-1,14-carbonate. CAS No. 186348-23-2. Molecular formula: C44H57NO17. Mole weight: 871.93. | |
| Orteronel | Orterone (TAK-700) is an orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones, such as progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Synonyms: TAK-700; TAK 700; TAK700. Grades: >98%. CAS No. 566939-85-3. Molecular formula: C18H17N3O2. Mole weight: 307.353. | |
| OSI-413 | OSI-413 is an impurity of Erlotinib, a selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Synonyms: OSI 413; OSI413; 7-(2'-Desmethyl) Erlotinib. Grades: >97%. CAS No. 183365-34-6. Molecular formula: C21H22ClN3O4. Mole weight: 415.87. | |
| OSI-7904L | OSI-7904L, also known as GW1843, OVI-237, GS7904L, is a potent, 3-methyl-substituted benzoquinazoline folate analog very specific for thymidylate synthase. Uses: Antineoplastic agents. Synonyms: GS7904L; GW1843; GW 1843; GW-1843; 1843U89; OVI-237; OVI 237; OVI237. CAS No. 139987-54-5. Molecular formula: C27H24N4O6. Mole weight: 500.51. | |
| Otelixizumab | Otelixizumab is a human anti-CD3 monoclonal antibody developed for the treatment of type 1 diabetes. Synonyms: ChAglyCD3; TRX 4; TRX4; TRX-4. CAS No. 881191-44-2. | |
| Otlertuzumab | Otlertuzumab is a humanized anti-CD37 monoclonal antibody developed for the cancer therapy. Otlertuzumab binds to CD37 on B-cells, which may result in antibody-dependent cell-mediated cytotoxicity (ADCC) and apoptosis. Synonyms: TRU-016. CAS No. 1372645-37-8. | |
| o-Topolin-9-glucoside | o-Topolin-9-glucoside is a highly significant compound with remarkable antioxidant and anti-inflammatory attributes, holding diverse applications in studying a wide array of pathological conditions encompassing cancer and neurodegenerative disorders. Synonyms: 6-(2-hydroxybenzylamino)-9-b-D-glucopyranosylpurine. CAS No. 160299-96-7. Molecular formula: C18H21N5O6. Mole weight: 403.39. | |
| Ouabain Octahydrate | Ouabain is a cardiac glycoside acting by Na(+)/K(+) ATPase, regulates transcription of MDR and MRP. Uses: Cardiotonic agents. Synonyms: (1b,3b,5b,11a)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide octahydrate; g-Strophanthin octahydrate; Acocantherine; 1b,3b,5b,11a,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside). Grades: >98%. CAS No. 11018-89-6. Molecular formula: C29H44O12 8H2O. Mole weight: 728.77. | |
| Oxacillin | Oxacillin is a semisynthetic penicillinase-resistant and acid-stable penicillin with an antimicrobial activity. It is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is widely used in resistant staphylococci infections. It binds to penicillin-binding proteins in the bacterial cell wall, thus blocking the synthesis of peptidoglycan, which leads to inhibition of cell growth and causes cell lysis. It was developed by Beecham and has been listed. Uses: Oxacillin is widely used in resistant staphylococci infections. Synonyms: [2S-(2,5,6)]-3,3-dimethyl-6-(methyl-3-phenylisoxaz-4-ole-carboxamide-7-oxy-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 5-Methyl-3-phenyl-4-isoxazolyl-penicillin. Grades: 98%. CAS No. 66-79-5. Molecular formula: C19H19N3O5S. Mole weight: 401.44. | |
| Oxelumab | Oxelumab is a human monoclonal antibody targeting human OX40L. OX40L is the ligand of OX40, which is expressed on activated T cells, natural killer (NK) cells and natural killer T (NKT) cells. Synonyms: R 4930; R4930; R-4930; Anti-Human OX40L. CAS No. 1186098-83-8. | |
| OXi8007 | OXi8007 is a vascular disrupting agent with potential anticancer activity. OXi8007 was found to be strongly cytotoxic against selected human cancer cell lines (GI50 = 36 nM against DU-145 cells, for example). OXi8007 also demonstrated pronounced interference with tumor vasculature in a preliminary in vivo study utilizing a SCID mouse model bearing an orthotopic PC-3 (prostate) tumor as imaged by color Doppler ultrasound. OXi8007 may be useful for the treatment of cancer. Synonyms: OXi-8007; OXi 8007; 2-(3-Phosphonooxy-4-methoxyphenyl)-3-(3,4,5-trimethoxybenzoyl)-6-methoxyindole disodium salt. Grades: 98%. CAS No. 288847-41-6. Molecular formula: C26H24NNa2O10P. Mole weight: 587.42. | |
| Oxylycorine | Oxylycorine is a selective topoisomerase II beta poison. It inhibits the growth of human tumour cells. It also inhibits the growth of human leukaemia cell lines. Uses: Oxylycorine inhibits the growth of human tumour cells. it also inhibits the growth of human leukaemia cell lines. Synonyms: AT-1840; AT 1840; AT1840; Ungerimine acetate; Lycobetaine acetate; 2-Hydroxy-4,5-dihydro-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium acetate. Grades: 98%. CAS No. 61221-41-8. Molecular formula: C18H15NO5. Mole weight: 325.32. | |
| Oxymorphone 3-b-D-glucuronide-D3 | Oxymorphone 3-b-D-glucuronide-D3 is an esteemed asset within the biomedical realm, leveraged extensively in the realm of opioid drug research, particularly oxymorphone. This compound serves as a catalyst for unraveling the intricate phenomena of glucuronidation concerning oxymorphone. Molecular formula: C23H24NO10D3. Mole weight: 480.47. | |
| Oxyphenonium bromide | Oxyphenonium bromide shows anticholinergic activity and can be used for research on the treatment of gastric and duodenal ulcers and for the relief of visceral spasms. Uses: Mydriatics. Synonyms: Spasmophen; Oxifenon; Oxyfenon; NSC-759248; Ethanaminium, 2-[(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]-N,N-diethyl-N-methyl-, bromide (1:1); Ammonium, diethyl(2-hydroxyethyl)methyl-, bromide, α-phenylcyclohexaneglycolate; Cyclohexaneglycolic acid, α-phenyl-, ester with diethyl(2-hydroxyethyl)methylammonium bromide; Diethyl(2-hydroxyethyl)methylammonium bromide α-phenylcyclohexaneglycolate; Ethanaminium, 2-[(cyclohexylhydroxyphenylacetyl)oxy]-N,N-diethyl-N-methyl-, bromide; (±)-Oxyphenonium bromide; Antrenil; Antrenyl; Antrenyl Duplex; Ba-5473; C 5473; dl-Oxyphenonium bromide; Oxyphenon; Spasmodin. Grades: 98%. CAS No. 50-10-2. Molecular formula: C21H34BrNO3. Mole weight: 428.40. | |
| Ozanezumab | Ozanezumab is a monoclonal antibody that targets Neurite Outgrowth Inhibitor (NOGO-A). Ozanezumab is undergoing cilinical trials for the treatment of amyotrophic lateral sclerosis and multiple sclerosis. Synonyms: GSK1223249; GSK 1223249; GSK-1223249. CAS No. 1310680-64-8. | |
| Ozuriftamab | Ozuriftamab is a naked antibody of receptor tyrosine kinase-like orphan receptor 2 (ROR2). CAS No. 2460399-44-2. | |
| P2045 | P2045 is a somatostatin analog cyclopeptide. Rhenium Re188 P2045 is the Rhenium complex of P2045. Phase I clinical trials demonstrated that Re-188 P2045 was well tolerated. Tc-99m P2045 imaging allows identification of patients who may benefit from this treatment. Although responses were not seen, survival for these heavily pretreated patients is interesting and merits further research. Synonyms: P 2045; P-2045; Cyclo(N-methyl-L-homocysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl), (11')-thioether with 3-[(2-mercaptoacetyl)amino]-L-alanyl-4-amino-L-phenylalanyl-L-cysteinyl-L-threonyl-L-serine. CAS No. 259746-53-7. Molecular formula: C68H91N15O17S2. Mole weight: 1454.68. | |
| P2Y14 Antagonist Prodrug 7j hydrochloride | A P2Y14 antagonist prodrug. Grades: 98%. CAS No. 1315308-19-0. Molecular formula: C33H32ClF3N2O3. Mole weight: 597.07. | |
| P7C3-A20 analog | P7C3-A20 demonstrated greater proneurogenic efficacy than a wide spectrum of currently marketed antidepressant drugs. P7C3-A20 showed neuroprotective properties in rodent models of Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury and age-related cognitive decline. Synonyms: P7C3-A20 analog; P7C3A20 analog; P7C3-A20-analog; defluoro-P7C3-A20. Grades: 98%. Molecular formula: C22H20Br2N2O. Mole weight: 488.22. | |
| P7C3-A20 hydrochloride | P7C3-A20 is an analogue of P7C3, and is a proneurogenic, neuroprotective agent. P7C3-A20 displayed increased activity and an improved toxicity profile compared to P7C3. Synonyms: P7C-3A20; P7C3A20; P7C 3A20. Grades: 98%. CAS No. 1485572-67-5. Molecular formula: C22H20Br2ClFN2O. Mole weight: 542.67. | |
| PAC-1 | PAC-1 is known as the first procaspase activating compound, which selectively induces apoptosis, or cell suicide, in cancerous cells. PAC-1 has shown good results in mouse models and is being further evaluated for use in humans. In 2010 a published study showed PAC-1 to be safe to research dogs, and a second study published later that same year reported that a PAC-1 derivative (called S-PAC-1) was well tolerated in a small Phase I Clinical Trial of pet dogs with lymphoma. Even at low doses of S-PAC-1, tumors regressed in 1/6 dogs, and the disease was stabilized (no additional tumor growth) in 3/6 dogs. Synonyms: 1-Piperazineacetic acid, 4-(phenylmethyl)-, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide; 1-Piperazineacetic acid, 4-(phenylmethyl)-, [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide; PAC 1; PAC1; Procaspase activating compound 1. Grades: >98%. CAS No. 315183-21-2. Molecular formula: C23H28N4O2. Mole weight: 392.49. | |
| padeliporfin | Padeliporfin is vascular-acting photosensitizer consisting of a water-soluble, palladium-substituted bacteriochlorophyll derivative with potential antineoplastic activity. Upon administration, paldeliporfin is activated locally when the tumor bed is exposed to low-power laser light; reactive oxygen species (ROS) are formed upon activation and ROS-mediated necrosis may occur at the site of interaction between the photosensitizer, light and oxygen. Vascular-targeted photodynamic therapy (VTP) with padeliporfin may allow tumor-site specific cytotoxicity while sparing adjacent normal tissues. Synonyms: WST11; WST 11; WST-11; Stakel; palladium-bacteriopheophorbide monolysine taurine. CAS No. 759457-82-4. Molecular formula: C37H41N5O9PdS. Mole weight: 838.24. | |
| Padoporfin | Padoporfin is a biocompatible polymer that is used to diagnose tumors. It has been shown to be effective against metastases in animal models and in humans with cervical cancer. Padoporfin is injected intravenously into tumor-bearing animals and then the visible fluorescence of the tumor, which indicates the presence of tumor vasculature, is detected using a methodologic technique called fluorescence imaging. This drug can also be used for treatment of some cancers such as breast cancer, prostate cancer and melanoma. Synonyms: WST-09; WST 09; WST09; Pd-Bacteriopheophorbide. CAS No. 274679-00-4. Molecular formula: C35H38N4O6Pd. Mole weight: 717.13. | |
| Palatinose Hydrate | Isomaltulose is another sugar substitute, and non-cariogenic substance. Synonyms: D-Fructose, 6-O-α-D-glucopyranosyl-, hydrate; 6-O-α-D-Glucopyranosyl-D-Fructose Hydrate; Isomaltulose Hydrate. Grades: ≥99%. CAS No. 343336-76-5. Molecular formula: C12H22O11.xH2O. Mole weight: 342.30 (anhydrous basis). | |
| Palbociclib N-Glucuronide | A salt of Palbociclib which is a drug for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: (2R,4R,6S)-6-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid. Grades: > 95%. Molecular formula: C30H37N7O8. Mole weight: 623.66. | |
| Panitumumab | Panitumumab is a humanized monoclonal antibody that binds to epidermal growth factor receptor (EGFR), which is often overexpressed in colorectal cancers. Combination of Panitumumab and EGFR reduces cell proliferation therefore inhibits colorectal cancers. It was approved for the treatment of EGFR-expressing metastatic colorectal cancer. Uses: The treatment of egfr-expressing metastatic colorectal cancer. Synonyms: Abenix; Abx-egf; Vectibix; Abx-egf mab; Unii-6A901E312a; Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal abx-egf heavy chain), disulfide with human monoclonal abx-egf light chain, dimer. CAS No. 339177-26-3. Molecular formula: C6398H9878N1694O2016S48. Mole weight: 144324.12. | |
| Panobacumab | Panobacumab is a human monoclonal antibody with antibacterial activity against Pseudomonas aeruginosa. Synonyms: KBPA101. CAS No. 885053-97-4. | |
| Pantoprazole sulfide-b-D-glucuronide | Pantoprazole sulfide-β-D-glucuronide is a researchpharmaceutical drug used in the biomedical industry acting as a metabolite of Pantoprazole, which is a proton pump inhibitor used to study gastroesophageal reflux disease (GERD), stomach ulcers and Zollinger-Ellison syndrome. Synonyms: 5-(Difluoromethoxy)-2-(3,4-dimethoxy-2-pyridinylmethylthio)-1-b-D-glucopyranosyl-1H-benzimidazole. CAS No. 867300-67-2. Molecular formula: C22H23F2N3O9S. Mole weight: 543.50. | |
| Pantothenic acid 2,4-di-O-b-D-galactopyranoside | Pantothenic acid 2,4-di-O-b-D-galactopyranoside is a compound serving as a catalyst for coenzyme A. Its wide-ranging utility spans studying vitamin inadequacies, ameliorating the ramifications of metabolic dysfunctions and tackling select dermatological afflictions. Molecular formula: C21H37NO15. Mole weight: 543.52. | |
| Panulisib | Panulisib, also known as AK151761, is a potent and selective imidazoquinoline based PI3K inhibitor with potential anticancer activity. Synonyms: AK151761; AK 151761; AK-151761; P7170; P 7170; P-7170; AGN-PC-0BMUW9; S9WA04F921. Grades: >98%. CAS No. 1356033-60-7. Molecular formula: C27H20F3N9. Mole weight: 527.51. | |
| para-(2-Thenoyl) hydratropic acid | A dual COX-1/COX-2 inhibitor. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: R-25061; R25061; R 25061; α-methyl-4-(2-thienylcarbonyl)?-benzeneacetic acid. CAS No. 40828-46-4. Molecular formula: C14H12O3S. Mole weight: 260.31. | |
| Paricalcitol Glucuronide | An impurity of Paricalcitol which is a drug used for the prevention and treatment of high levels of a certain natural substance made by the body (parathyroid hormone) in patients with long-term kidney disease. Synonyms: (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-Octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol 25-b-D-glucuronide; 1a,25-Dihydroxy-19-nor-vitamin D2 25-b-D-glucuronide; Zemplar 25-b-D-glucuronide. Grades: > 95%. CAS No. 1260588-15-5. Molecular formula: C33H52O9. Mole weight: 592.76. | |
| PC-046 | PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with distribution to both plasma and bone marrow. No myelosuppression was seen in non-tumor bearing SCID mice given a single dose just under the acute lethal dose. The COMPARE algorithm in the NCI-60 cell line panel demonstrated that PC-046 closely correlated to other known tubulin destabilizing agents (correlation coefficients ?0.7 for vincristine and vinblastine). Mechanism of action studies showed cell cycle arrest in metaphase and inhibition of tubulin polymerization. Overall, these studies show that PC-046 is a synthetically-derived, small molecule microtubule destabilizing agent. Advantages over existing microtubule destabilizing agents include ease of synthesis, lack of MDR cross-resistance, good oral bioavailability and the lack of acute myelotoxicity. Synonyms: PC 046; PC046; NSC-756784; 5-(4-methoxyphenyl)-2-(3-(3-methoxyphenyl)pyridin-4-yl)oxazole. Grades: 98%. CAS No. 1202401-59-9. Molecular formula: C22H18N2O3. Mole weight: 358.39. | |
| PCA 4248 | PCA 4248 is a PAF antagonist. It can inhibit rabbit platelet aggregation with an IC50 value of 1.05 μM. Synonyms: PCA-4248; PCA4248; 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid methyl 2-(phenylthio)ethyl ester. Grades: ≥95%. CAS No. 123875-01-4. Molecular formula: C19H23NO4S. Mole weight: 361.46. | |
| PD0166285 | PD0166285 is a potent Wee1 inhibitor and Chk1 inhibitor with activity at nanomolar concentrations. This G2 checkpoint abrogation by PD0166285 was demonstrated to kill cancer cells, there at a toxic highest dose of 0.5 muM in some cell lines for exposure periods of no longer than 6 hours. The deregulated cell cycle progression may have ultimately damaged the cancer cells. We herein report one of the mechanism by which PD0166285 leads to cell death in the B16 mouse melanoma cell line. Synonyms: PD166285; 6-(2,6-dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one; 6-(2,6-Dichlorophenyl)-2-[4-(2-diethylaminoethoxy)phenylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-. Grades: ≥98%. CAS No. 185039-89-8. Molecular formula: C26H27Cl2N5O2. Mole weight: 512.44. | |
| PD0407824 | PD0407824 is a potent and selective inhibitor of checkpoint kinase Chk1 and WEE1 with IC50s of 47 and 97 nM, respectively. It is a BMP chemical sensitizer that increases cell sensitivity to subthreshold amounts of BMP4. It has potential anticancer activity. Synonyms: PD 407824; 9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione; Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 9-hydroxy-4-phenyl-. Grades: ≥98%. CAS No. 622864-54-4. Molecular formula: C20H12N2O3. Mole weight: 328.32. | |
| PD089828 | PD089828 is a potent FGFR inhibitor, which inhibits human full-length fibroblast growth factor (FGF) receptor-1 (FGFR-1), platelet-derived growth factor (PDGF) receptor beta subunit (PDGFR-beta), Src nonreceptor tyrosine kinase (c-Src) and epidermal growth factor (EGF) receptor (EGFR) tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 0.15 +/- 0.02 (n = 4), 0.18 +/- 0.04 (n = 3), 1.76 +/- 0.28 (n = 4) and 5.47 +/- 0.78 (n = 6) microM, respectively. The results highlight the biological characteristics of PD 089828 as a novel, broadly active protein tyrosine kinase inhibitor with long-lasting but reversible cellular effects. The potential therapeutic use of these broadly acting, nonselective inhibitors as antiproliferative and antimigratory agents could extend to such diseases as cancer, atherosclerosis and restenosis in which redundancies in growth-signaling pathways are known to exist. Synonyms: PD-089828; PD 089828; N-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea; 1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-(2-methyl-2-propanyl)urea; EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor. Grades: ≥98%. CAS No. 179343-17-0. Molecular formula: C18H18Cl2N6O. Mole weight: 405.28. | |
| PD 121373 | This active molecular has a Benzothiopyrano-indazole structure and the benzothiopyranoindazoles are potent inhibitors of nucleic acid synthesis, reducing both DNA and RNA synthesis to the same extent at similar concentrations. PD 121373 made DNA single- and double-strand breaks in a time and concentration-dependent manner in L1210 cells. In 2003, PD 121373 was in Phase-II for Colorectal cancer, Solid tumours and Prostate cancer in USA. Uses: Treatment of colorectal cancer; prostate cancer; solid tumours. Synonyms: PD 121373; PD-121373; PD121373; 5-((2-aminoethyl)amino)-2-(2-(diethylamino)ethyl)-2H-thiochromeno[4,3,2-cd]indazol-9-ol,Sedoxantrone. Grades: 98%. CAS No. 113457-06-0. Molecular formula: C21H27N5OS. Mole weight: 397.54. | |
| PD-128763 | PD-128763 is a selective inhibitor of poly(ADP-ribose) polymerase. Synonyms: PD 128763; PD128763; 3,4-Dihydro-5-methyl-1(2H)-isoquinolinone; 3,4-dihydro-5-methylisoquinolinone. Grades: 0.98. CAS No. 129075-56-5. Molecular formula: C10H11NO. Mole weight: 161.20. | |
| PD128907 HCl | PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. Synonyms: PD 128907 HCl; PD-128907 HCl. Grades: >98%. CAS No. 112960-16-4. Molecular formula: C14H20ClNO3. Mole weight: 285.77. | |
| PD166326 | PD166326 is one of the most potent members of the pyridopyrimidine class of protein tyrosine kinase inhibitors. In mice with the CML-like disease, PD166326 rapidly inhibited Bcr/Abl kinase activity after a single oral dose and demonstrated marked antileukemic activity in vivo. In vivo, PD166326 was also superior to imatinib mesylate in inhibiting the constitutive tyrosine phosphorylation of numerous leukemia-cell proteins, including the src family member Lyn. PD166326 also prolonged the survival of mice with imatinib mesylate-resistant CML induced by the Bcr/Abl mutants P210/H396P and P210/M351T. Synonyms: PD-166326; PD 166326; 6-(2,6-Dichlorophenyl)-2-[[3-(hydroxymethyl)phenyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one. CAS No. 185039-91-2. Molecular formula: C21H16Cl2N4O2. Mole weight: 427.28. | |
| PD166866 | PD166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. PD166866 has clear antiproliferative effects. Uses: Protein kinase inhibitors. Synonyms: PD166866; PD-166866; PD 166866. Grades: 98%. CAS No. 192705-79-6. Molecular formula: C20H24N6O3. Mole weight: 396.45. | |
| PD180970 | PD180970 is a novel Bcr-Abl inhbiitor. PD180970 inhibited in vivo tyrosine phosphorylation of p210Bcr-Abl (IC50 = 170 nM) and the p210BcrAbl substrates Gab2 and CrkL (IC50 = 80 nM) in human K562 chronic myelogenous leukemic cells. In vitro, PD180970 potently inhibited autophosphorylation of p210Bcr-Abl (IC50 = 5 nM) and the kinase activity of purified recombinant Abl tyrosine kinase (IC50 = 2.2 nM). Incubation of K562 cells with PD180970 resulted in cell death. PD180970 is among the most potent inhibitors of the p210Bcr-Abl tyrosine kinase, which is present in almost all cases of human chronic myelogenous leukemia. PD180970 is a promising candidate as a novel therapeutic agent for Bcr-Abl-positive leukemia. Synonyms: PD 180970; PD-180970; PF-1515965; PF 1515965; PF1515965; 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-. Grades: ≥95%. CAS No. 287204-45-9. Molecular formula: C21H15Cl2FN4O. Mole weight: 429.27. | |
| PD184161 | PD184161 is an orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner more effectively than PD098059 or U0126. PD184161 inhibited cell proliferation and induced apoptosis at concentrations of > or = 1.0 microM in a time- and concentration-dependent manner. PD184161 has antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity. PD184161 is unable to suppress MEK activity in HCC xenografts in the long term. Synonyms: PD 184161; PD-184161; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide. CAS No. 212631-67-9. Molecular formula: C17H13BrClF2IN2O2. Mole weight: 557.56. | |
| PD-321852 | PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to>30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A; in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines. Synonyms: PD0321852; PD321852; 4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(methylamino)propyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione. Grades: 98%. CAS No. 622856-21-7. Molecular formula: C24H19Cl2N3O3. Mole weight: 468.33. | |
| PDM 2 | PDM 2 is an analog of resveratrol and a potent and selective aryl hydrocarbon receptor (AhR) antagonist. AhR is a transcription factor that acts as a sensor of xenobiotic chemicals and modulator of enzymes such as cytochrome P450s. Synonyms: 1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene. Grades: ≥98%. CAS No. 688348-25-6. Molecular formula: C14H9Cl3. Mole weight: 283.6. | |
| PDMP hydrochloride | PDMP is an inhibitor of glucosyl ceramide synthase that inhibits the synthesis and shedding of gangliosides. It reduces lysosomal activity, enhances lysosomal permeability and cytotoxicity in cells. PDMP has been used as a tool for studying various effects of endogenous glycosphingolipids. Synonyms: DL-threo-PDMP hydrochloride; DL-erythro/threo-PDMP hydrochloride; 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol HCl; (+/-)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride. Grades: ≥98%. CAS No. 73257-80-4. Molecular formula: C23H38N2O3·HCl. Mole weight: 427. | |
| Pegdinetanib | Pegdinetanib is a highly specific, synthetic peptide vascular endothelial growth factor receptor-2 (VEGFR-2) antagonist with potential antiangiogenic activity. Derived from human fibronectin with a proprietary protein engineering process, pegdinetanib may block the activation of VEGFR-2 by all known activating ligands, thereby inhibiting the growth of new tumor blood vessels. Synonyms: Pegdinetanib; BMS-844203; BMS 844203; BMS844203; CT-322; CT 322; CT322; Brand name: Adnectin; Angiocept. CAS No. 906450-24-6. Molecular formula: C27H46N6O13S. Mole weight: 694.75. | |
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