BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Argadin | Argadin is a biomedical product used in the research of chronic obstructive pulmonary disease (COPD). Synonyms: 4-[ (1S, 4R, 10S, 13S, 16S, 18R)-10-[3-[[acetamido (amino)methylidene]amino]propyl]-18-hydroxy-16- (1H-imidazol-5-ylmethyl)-3, 9, 12, 15, 20-pentaoxo-2, 8, 11, 14, 17-pentazatricyclo[15. 2. 1. 04, 8]icosan-13-yl]butanoic acid. CAS No. 289665-92-5. Molecular formula: C29H42N10O9. Mole weight: 674.71. |  |
| Arg-Arg β-Naphthylamide Trihydrochloride | A specific substrate for dipeptidyl peptidase III. Synonyms: Arg-Arg beta-naphthylamide trihydrochloride; H-Arg-Arg-βNA 3 HCl; L-Argininamide,L-arginyl-N-2-naphthalenyl-, trihydrochloride (9CI). Grades: 95%. CAS No. 100900-26-3. Molecular formula: C22H36Cl3N9O2. Mole weight: 564.94. | |
| Argentinine | Cas No. 16625-57-3. | |
| Arg-Gly-Asp-Cys acetate | Arg-Gly-Asp-Cys, a fibronectin binding motif to cell adhesion molecules, inhibits platelet aggregation and fibrinogen binding. Synonyms: L-arginyl-glycyl-L-alpha-aspartyl-L-cysteine; RGDC peptide. Molecular formula: C17H31N7O9S. Mole weight: 509.54. | |
| Arg-Gly-Asp-Ser acetate | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Molecular formula: C17H31N7O10. Mole weight: 493.47. | |
| Arg-Ile | Synonyms: arginylisoleucine; L-arginyl-L-isoleucine; Arginyl-Isoleucine; RI dipeptide; Arginine Isoleucine dipeptide. Grades: 95%. CAS No. 62632-70-6. Molecular formula: C12H25N5O3. Mole weight: 287.36. | |
| Arginine vasotocin trifluoroacetate salt | Arginine vasotocin (AVT) is the non-mammalian homolog of arginine vasopressin (AVP) and serves as an important modulator of social behavior in addition to its peripheral functions related to osmoregulation, reproductive physiology, and stress hormone release. AVT is aslo homologous to arginine vasopressin in mammals and is endogenously released from the neurohypophysis primarily in response to hyperosmotic stimuli and associated cellular dehydration. Arginine vasotocin is a nonapeptide hormone agonist of the AVT receptor with EC50 of 13 nM for eliciting membrane. Synonyms: [Arg8]-Vasotocin; AVT. Grades: ≥95%. Molecular formula: C43H67N15O12S2·xCF3COOH. Mole weight: 1050.22. | |
| Arginyl-Methionine | Synonyms: Arg-Met; L-arginyl-L-methionine; RM dipeptide; N-L-Arginyl-L-methionine; Arginine Methionine dipeptide. Grades: ≥98%. CAS No. 45243-23-0. Molecular formula: C11H23N5O3S. Mole weight: 305.40. | |
| Aripiprazole EP Impurity B | An impurity of Aripiprazole, an atypical antipsychotic used to treat schizophrenia. Synonyms: DCPP; 1-(2,3-Dichlorophenyl)-piperazine; 2,3-Dichlorophenylpiperazine. CAS No. 41202-77-1. Molecular formula: C10H12Cl2N2. Mole weight: 231.12. | |
| Aripiprazole EP Impurity C | An impurity of Aripiprazole, an atypical antipsychotic used to treat schizophrenia. Synonyms: Deschloroaripiprazole; Deschloro aripiprazole; Aripiprazole 3-Deschloro Impurity. CAS No. 203395-81-7. Molecular formula: C23H28ClN3O2. Mole weight: 413.94. | |
| Aristolactam I | Aristolactam I is a highly natural compound widely employed in the biomedical sector, showcasing its exceptional properties in studying cancerous growth and impeding tumor progression. By effectively hindering the complex process of DNA synthesand prompting programmed cell death, this natural compound emerges as an indispensable tool in the investigation of Aristolochic acid-orchestrated nephropathy and its accompanying mutagenic consequences. Synonyms: 7-(2'-Deoxyadenosin-N6-yl)aristolactam I. Grades: >98%. CAS No. 127191-86-0. Molecular formula: C27H22N6O7. | |
| Arjunetin | Arjunetin is found in Potentilla anserina, it shows antioxidant and anti-inflammatory activities. Synonyms: 24-Deoxysericoside. Grades: > 95%. CAS No. 31297-79-7. Molecular formula: C36H58O10. Mole weight: 650.84. | |
| Arjungenin | Arjungenin is a triterpenoid showing antiviral, anti-inflammatory and β-glucuronidase inhibitory activity. Synonyms: Arjugenin. Grades: 98%. CAS No. 58880-25-4. Molecular formula: C30H48O6. Mole weight: 504.7. | |
| ARL 17477 dihydrochloride | The hydrochloride salt form of ARL 17477, which has been found to be a nitric oxide synthase (NOS) inhibitor and could induce apoptosis/cell death in leukemia cells. Synonyms: 2-Thiophenecarboximidamide, N-[4-[2-[[ (3-chlorophenyl) methyl]amino]ethyl]phenyl]-, hydrochloride (1:2); 2-Thiophenecarboximidamide, N-[4-[2-[[ (3-chlorophenyl) methyl]amino]ethyl]phenyl]-, dihydrochloride; ARL17477 dihydrochloride; ARL-17477 dihydrochloride; N-[4-[2-[[ (3-Chlorophenyl) methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 866914-87-6. Molecular formula: C20H20ClN3S.2HCl. Mole weight: 442.83. | |
| ARL 67156 trisodium salt | The sodium salt form of ARL 67156, which has been found to be an ecto-ATPase inhibitor. Synonyms: ARL 67156; ARL-67156; ARL67156; 6-N,N-Diethyl-D-β,γ-dibromomethyleneATP trisodium salt. Grades: ≥98% by HPLC. CAS No. 1021868-83-6. Molecular formula: C15H21Br2N5O12P3.3Na. Mole weight: 785.06. | |
| AR-M 1896 acetate | AR-M 1896 acetate is the selective galanin GAL2 receptor agonist used as an antiepileptogenic agent. Synonyms: H-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-NH2.CH3CO2H; L-tryptophyl-L-threonyl-L-leucyl-L-asparagyl-L-seryl-L-alanyl-glycyl-L-tyrosyl-L-leucyl-L-leucinamide acetic acid. Grades: ≥95%. Molecular formula: C56H85N13O16. Mole weight: 1196.35. | |
| Arm-390Hcl | Cas No. 209808-47-9. | |
| ARN2966 | ARN2966, also called 2-PMAP, as a Amyloid-β inhibitor, is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: 2-(pyridin-2-ylmethylamino)phenol; 2-PMAP; ARN2966; ARN-2966; Phenol, 2-[(2-pyridinylmethyl)amino]-; 102212-26-0; AGN-PC-0031SD; GTPL7530; 2-(2-Pyridylmethylamino)phenol; SCHEMBL10886688; AOB1080; SYN5152; 2-(pyridin-2-ylmethylamino)phenol; 3970AH; ZINC34411048; AKOS022987680; CS-3335; HY-18292; ARN-2966; CS 3335; HY 18292; ARN 2966; CS3335; HY18292; ARN2966. Grades: > 98%. CAS No. 102212-26-0. Molecular formula: C12H12N2O. Mole weight: 200.24. | |
| ARNAX | ARNAX is a TLR3-specific agonist that does not activate the mitochondrial antiviral-signaling protein (MAVS) pathway, and thus does not induce systemic inflammation. Synonyms: GpC ODN+MV DI RNA. | |
| Arnicolide C | Arnicolide C is found in the herbs of Centipeda minima, it shows significant antiallergy activity. Synonyms: Arnicolide C; ArnicolideC; 34532-67-7; [(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] 2-methylpropanoate; HY-N6842; AKOS030632143; NCGC00347562-02; MS-25050; 1ST167749; CS-0100261; E80740. Grades: > 95%. CAS No. 34532-67-7. Molecular formula: C19H26O5. Mole weight: 334.41. | |
| Arnidiol | Arnidiol is a triterpenoid with anti-inflammatory activity. Synonyms: Arnidenediol; Ainidiol. Grades: 0.98. CAS No. 6750-30-7. Molecular formula: C30H48O2. Mole weight: 440.7. | |
| Aromadendrene oxide 2 | Aromadendrene oxide 2 (CAS# 85710-39-0 ) is a useful research chemical. Synonyms: (1aR,4S,4aR,7R,7aS,7bS)-1,1,7-trimethylspiro[2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulene-4,2'-oxirane]. CAS No. 85710-39-0. Molecular formula: C15H24O. Mole weight: 220.35. | |
| Aroplatin | Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. The liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile. CAS No. 114488-24-3. Molecular formula: C26H52N2O4Pt. Mole weight: 651.79. | |
| ARP 100 | ARP 100 has been found to be a selective inhibitor of MMP-2 and could show anti-invasive properties in HT1080 fibrosarcoma cells at some extent. Synonyms: ARP100; ARP-100; ARP 100; 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide. Grades: ≥98% by HPLC. CAS No. 704888-90-4. Molecular formula: C17H20N2O5S. Mole weight: 364.42. | |
| ARP 101 | ARP 101 is a Selective MMP-2 inhibitor with IC50 value of 0.81 nM. It displays nearly 600-fold selectivity over MMP-1 (IC50 value 486 nM). ARP 101 has diverse physiological roles including wound healing, cancer metastasis, angiogenesis and so on. Synonyms: ARP-101; ARP 101; ARP101; (2R)-N-hydroxy-3-methyl-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]butanamide. Grades: 98%. CAS No. 849773-63-3. Molecular formula: C20H26N2O5S. Mole weight: 406.50. | |
| Arphamenine B hemisulfate | Arphamenine B is a specific inhibitor of aminopeptidase B, which is first isolated from bacteria. Arphamenine B Hemisulfate is the hemisulfate form. Arphamenine B share the same property with aminopeptidase inhibitors bestatin and amastatin, they all enhance imune responses. Synonyms: Benzenepropanoic acid, α-[(3S)-3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxy-, (αR)-, sulfate (2:1) (salt); Benzenepropanoic acid, α-[3-amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxy-, monohydrochloride, [S-(R*,S*)]-, sulfate (2:1) (salt); Arphamenine B sulfate; (αR)-α-[(3S)-3-Amino-6-[(aminoiminomethyl)amino]-2-oxohexyl]-4-hydroxybenzenepropanoic acid, sulfate (2:1) (salt). Grades: ≥95%. CAS No. 144110-38-3. Molecular formula: C16H24N4O4·1/2H2SO4. Mole weight: 385.43. | |
| ARQ-621 | ARQ-621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Over-expression of Eg5 causes genomic instability and tumor formation in mice. Preclinical data shows anti-tumor activity of ARQ 621 across a wide range of cell lines from human solid and hematological malignancies. Synonyms: NSC-771644; N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylamino)-2-quinazolinyl]-3-butyn-1-yl]-2-fluorobenzamide; (R)-N-(3-Aminopropyl)-3-chloro-N-(1-(7-chloro-4-oxo-3-(phenylamino)-3,4-dihydroquinazolin-2-yl)but-3-yn-1-yl)-2-fluorobenzamide; Benzamide, N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylamino)-2-quinazolinyl]-3-butyn-1-yl]-2-fluoro-. Grades: ≥95%. CAS No. 1095253-39-6. Molecular formula: C28H24Cl2FN5O2. Mole weight: 552.43. | |
| ARQ 736 disodium salt | This active molecular is a Proto oncogene protein b raf and Vascular endothelial growth factor A inhibitor originated by ArQule. ARQ 736 is effective in killing cancer cell lines that harboring at least one mutated b raf allele. The b raf protein is really a very important signaling molecule in the MAPK (mitogen activated protein kinase) signaling pathway and it relates to pathogenesis of variety kinds of cancer. In Mar 2014, Phase-I for Solid tumours (late-stage disease) was discontinued in USA. Uses: Solid tumours. Synonyms: ARQ 736 disodium salt; ARQ736 disodium salt; ARQ-736 disodium salt; sodium (R)-(3-(5-(2-((1-((1-methyl-1H-pyrazol-3-yl)sulfonyl)piperidin-3-yl)amino)pyrimidin-4-yl)imidazo[2,1-b]oxazol-6-yl)phenoxy)methyl phosphate;1228237-47-5 free acid. Grades: 98%. CAS No. 1228237-57-7. Molecular formula: C25H25N8Na2O8PS. Mole weight: 674.54. | |
| AR-R 17779 hydrochloride | AR-R17779 has been found to be a selective alpha7 nicotinic agonist and could probably reduce blood pressure and serum lipid levels. Synonyms: AR-R 17779 hydrochloride; AR-R-17779 hydrochloride; AR-R17779 hydrochloride; ARR17779 hydrochloride; (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride. Grades: ≥98% by HPLC. CAS No. 178419-42-6. Molecular formula: C9H14N2O2.HCl. Mole weight: 218.68. | |
| ARRY 403 | ARRY-403 is an orally available Glucokinase stimulants originated by Array BioPharma. ARRY-403 activates human glucokinase in vitro with EC50 of 79 nM at 5 mM glucose and Vmax = 134% compared to the no activator control. It exhibits good in vitro drug-like properties and selectivity against broad panels of receptors and enzymes. But,treatment for Type 2 diabetes mellitus was discontinued. Uses: Type 2 diabetes mellitus. Synonyms: ARRY-403; ARRY-403; ARRY-403; AMG-151; AMG 151; AMG151;(1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol. Grades: 98%. CAS No. 1304015-76-6. Molecular formula: C20H18N6O3S2. Mole weight: 454.53. | |
| ARRY-797 | ARRY-797 is a potent and selective p38α inhibitor that inhibits LPS-induced IL-6. Synonyms: p38alpha inhibitor 1; p38α inhibitor 1; 5-(2,4-Difluorophenoxy)-N-(2-(dimethylamino)ethyl)-1-isobutyl-1H-indazole-6-carboxamide; 1H-Indazole-6-carboxamide, 5-(2,4-difluorophenoxy)-N-[2-(dimethylamino)ethyl]-1-(2-methylpropyl)-; ARRY 797; ARRY797. Grades: ≥95%. CAS No. 1036404-17-7. Molecular formula: C22H26F2N4O2. Mole weight: 416.46. | |
| ART558 | ART558 is a nanomolar potent, selective, allosteric DNA polymerase activity of Polθ inhibitor with IC50 of 7.9 nM. ART558 can be used in cancer research. Synonyms: GLXC-26260. CAS No. 2603528-97-6. Molecular formula: C21H21F3N4O2. Mole weight: 418.41. | |
| ART812 | ART812 is an orally active DNA polymerase Polθ inhibitor with IC 50 of 7.6 nM. ART812 also significantly inhibited PARP-resistant BRCA1 mutant tumor growth in rats. Synonyms: HY-139289. CAS No. 2607138-82-7. Molecular formula: C19H16ClF4N3O4. Mole weight: 461.79. | |
| ART-CHEM-BB B025267 | ART-CHEM-BB B025267 up-regulates the production of utrophin with an EC50 of 1.8 μM, which can be used in research on the treatment of Duchenne muscular dystrophy. Synonyms: 2-(4-(Diethylamino)phenyl)-6-methyl-2H-benzo[d][1,2,3]triazol-5-amine; 2-[4-(Diethylamino)phenyl]-6-methyl-2H-1,2,3-benzotriazol-5-amine; 2-[4-(Diethylamino)phenyl]-6-methyl-2H-benzotriazol-5-amine. Grades: ≥95%. CAS No. 381208-40-8. Molecular formula: C17H21N5. Mole weight: 295.38. | |
| Arundinin | Arundinin is found in Bletilla striata. Grades: > 95%. CAS No. 148225-38-1. Molecular formula: C22H22O4. Mole weight: 350.41. | |
| ARV-471 | ARV-471, an oral estrogen receptor PROTAC protein degrader for the treatment of breast cancer, is an heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes. It leads to ubiquitylation and subsequent degradation of estrogen receptors through the proteasome. In ER positive breast cancer cell lines, it has a strong ability to degrade ER with a half-maximal degradation concentration (DC50) of ~2 nM. Synonyms: ARV471; ARV 471; (S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-; Vepdegestrant; (3S)-3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione. Grades: ≥95%. CAS No. 2229711-68-4. Molecular formula: C45H49N5O4. Mole weight: 723.90. | |
| ARV-825 | ARV-825 is a BRD4 inhibitor based on PROTAC technology. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4. In post-myeloproliferative neoplasm secondary (s) AML cell lines, treatment with ARV-825 induces apoptosis and inhibits cell proliferation. Synonyms: 2- ( (S) -4- (4-chlorophenyl) -2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl) -N- (4- (2- (2- (2- (2- ( (2- (2, 6-dioxopiperidin-3-yl) -1, 3-dioxoisoindolin-4-yl) amino) ethoxy) ethoxy) ethoxy) ethoxy) phenyl) acetamide. Grades: ≥98%. CAS No. 1818885-28-7. Molecular formula: C46H47ClN8O9S. Mole weight: 923.44. | |
| Arvanil | Arvanil is a vanilloid TRPV1 (VR1) and cannabinoid CB1 agonist with Ki values of 0.3 and 0.5 μM respectively. It increases lung tidal volume, diaphragm activity, mean arterial blood pressure and inhibits lymphocyte proliferation. It also inhibits the anandamide transporter. It has analgesic, vasodilatory and anti-inflammatory effects in vivo. It is a structural analog of capsaicin. It induces analgesia in rat and mouse models of pain. It is resistant to hydrolysis by FAAH. It is a potent inhibitor of anandamide accumulation. It inhibits growth of astrocytoma xenograft tumors in mice. It mimics the effect of neural precursor cells and has been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids. Synonyms: RT-011322; B-6699; I14-44667; RT011322; B6699; I1444667; N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-Eicosatetraenamide; N-Vanillylarachidonamide; (all-Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-eicosatetraenamide. Grades: ≥98% by HPLC. CAS No. 128007-31-8. Molecular formula: C28H41NO3. Mole weight: 439.64. | |
| Arzoxifene | Arzoxifene, also known as LY353381, a synthetic aromatic derivative with anti-estrogenic properties, displays greater bioavailability and higher anti-estrogenic potency in the breast than another selective estrogen receptor modulators (SERMs),raloxifene. Synonyms: 2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol; 4'F-DMA; 182133-27-3 (hydrochloride salt); arzoxifene; LY 353381; LY-353381; LY353381. Grades: >98%. CAS No. 182133-25-1. Molecular formula: C28H29NO4S. Mole weight: 475.60. | |
| AS03 | AS03 is an Adjuvant System composed of α-tocopherol, squalene and polysorbate 80 in an oil-in-water emulsion. AS03 has been shown to trigger transient NF-κB-dependent innate immune responses. | |
| AS 1269574 | GPR119 has been found to be a GPR119 agonist and could stimulate the activity of proglucagon gene promoter. Synonyms: AS1269574; AS-1269574; AS 1269574; 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol. Grades: ≥98% by HPLC. CAS No. 330981-72-1. Molecular formula: C13H14BrN3O. Mole weight: 308.17. | |
| AS 1517499 | AS 1517499 is a potent and selective STAT6 inhibitor (IC50 = 21 nM). Synonyms: AS-1517499; AS1517499; AS 1517499. 4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide. Grades: 99%. CAS No. 919486-40-1. Molecular formula: C20H20ClN5O2. Mole weight: 397.86. | |
| AS 15 (immune adjuvant) | AS 15 (immune adjuvant) is a liposomal immune adjuvant contg. CpG 7909, monophosphoryl lipid A, and Quillaja saponin 21. Synonyms: AS 15. CAS No. 1351362-53-2. | |
| AS-1669058 | AS-1669058 is a G-protein-coupled receptor 119 (GPR119) agonist originated by Astellas Pharma. No recent reports of development were identified for preclinical development in Type-2-diabetes-mellitus in Japan. Uses: Type 2 diabetes mellitus. Synonyms: 3-(2-((2-(4-bromo-2,5-difluorophenyl)-6-methylpyrimidin-4-yl)amino)ethyl)pyridine 1-oxide;AS 1535907; AS 1669058; AS 1907417; GPR119 agonists - Astellas Pharma;1395553-32-8(OXLATE). Grades: 98%. CAS No. 1395553-31-7. Molecular formula: C18H15BrF2N4O. Mole weight: 421.24. | |
| AS-1669058 oxalate | AS-1669058 is a G-protein-coupled receptor 119 (GPR119) agonist originated by Astellas Pharma. No recent reports of development were identified for preclinical development in Type-2-diabetes-mellitus in Japan. Uses: Type 2 diabetes mellitus. Synonyms: AS-1669058 oxalate; AS 1669058 oxalate; AS1669058 oxalate; 3-(2-((2-(4-bromo-2,5-difluorophenyl)-6-methylpyrimidin-4-yl)amino)ethyl)pyridine 1-oxide oxalate. Grades: 98%. CAS No. 1395553-32-8. Molecular formula: C18H15BrF2N4O.C2H2O4. Mole weight: 511.28. | |
| AS 1892802 | AS 1892802 has been found to be an ATP-competitive ROCK inhibitor and could show analgesic activities at some extent. Synonyms: AS 1892802; AS1892802; AS-1892802; N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea. Grades: ≥99% by HPLC. CAS No. 928320-12-1. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
| AS 19 | AS 19 has been found to be a potent SR-7 agonist and could probably enhance memory consolidation. Synonyms: AS 19; AS-19; AS19; (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin. Grades: ≥98% by HPLC. CAS No. 1000578-26-6. Molecular formula: C18H25N3. Mole weight: 283.41. | |
| AS1940477 | AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFα- and IL-1 β-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. AS1940477 was also found to potently inhibit TNF production in whole blood (IC(50)=12 nM) and effectively inhibited TNFα production induced by systemically administered LPS in rats at less than 0.1mg/kg (ED(50)=0.053 mg/kg) with an anti-inflammatory effect lasting for 20h after oral administration. Overall, this study demonstrated that AS1940477 is a novel and potent p38 MAPK inhibitor and may be useful as a promising anti-inflammatory agent for treating inflammatory disorders. Synonyms: AS1940477; AS-1940477; AS 1940477. CAS No. 928344-12-1. Molecular formula: C24H22FN5O2. Mole weight: 431.47. | |
| AS 2034178 | AS 2034178 has been found to be a FFA1/GPR40 agonist and could probably be used against diabetes. Synonyms: AS 2034178; AS2034178; AS-2034178; 2-Fluoro-4- [ [ [1, 2, 3, 4-Tetrahydro-1- (2-phenoxyethyl) -5-quinolinyl] methyl] amino] benzenepropanoic acid. Grades: ≥98% by HPLC. CAS No. 1030846-42-4. Molecular formula: C27H29FN2O3. Mole weight: 448.53. | |
| AS601245 | AS601245 is a JNK Inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. Synonyms: AS601245; AS-601245; AS 601245. Grades: >98%. CAS No. 345987-15-7. Molecular formula: C20H16N6S. Mole weight: 372.45. | |
| AS-601811 | AS-601811 is a 5-α reductase (type 1) inhibitor developed for the treatment of acne. Synonyms: 4,8-dimethyl-1,2,5,6-tetrahydrobenzo[f]quinolizin-3-one; AS-601811; AS 601811; AS601811; UNII-LIV8A6AE5F. Grades: >98%. CAS No. 194979-95-8. Molecular formula: C15H17NO. Mole weight: 227.307. | |
| AS 602801 | AS 602801 is a novel, orally active inhibitor of JNK. It blocked T-lymphocyte proliferation and induced apoptosis. Synonyms: AS602801; AS-602801; AS 602801; PGL5001; PGL-5001; PGL 5001; Bentamapimod. Grades: >98%. CAS No. 848344-36-5. Molecular formula: C25H23N5O2S. Mole weight: 457.55. | |
| ASC-J9 | Cas No. 52328-98-0. | |
| Ascomycin 19-epimer | | |
| Ascorbyl Propyl Hyaluronate | Ascorbyl propyl hyaluronate is a perfect combination of hyaluronic acid and vitamin C, overcoming the instability of vitamin C, and is a high-quality raw material for improving wrinkles, moisturizing, calming, and whitening skin. Synonyms: Hyaluronic acid, ester with 3-O-(3-hydroxypropyl)-L-ascorbic acid. CAS No. 1800464-57-6. | |
| Asenapine hydrochloride | Asenapine hydrochloride, also called Org 5222 and HSDB 8061, shows high affinity for numerous receptors including 5-HT receptor and adrenergic receptor. (pKi: 5-HT1A= 8.6, 5-HT1B= 8.4, 5-HT2A= 10.2, 5-HT2B= 9.8, 5-HT2C= 10.5, 5-HT5A= 8.8, 5-HT6= 9.5, and. Synonyms: Asenapine (hydrochloride); 1412458-61-7; DTXSID10678678; CS-1053; HY-16567; W-6082; CS 1053; HY 16567; W 6082; CS1053; HY16567; W6082; (3aS,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole--hydrogen chloride (1/1). CAS No. 1412458-61-7. Molecular formula: C17H17Cl2NO. Mole weight: 322.23. | |
| Asiaticoside B | Asiaticoside B is a triterpenoid isolated from Centella asiatica (L.) Urban, showing anti-cancer activity and notable cytotoxicity against HepG2 and MCF-7 cancer cell lines. Synonyms: Terminoloside. Grades: 0.98. CAS No. 125265-68-1. Molecular formula: C48H78O20. Mole weight: 975.13. | |
| ASM-024 | ASM-024 is a small synthetic compound and a potent nicotinic receptor agonist developed for airway inflammatory diseases as the primary target therapeutic indication. It acts as a dual anti-inflammatory and bronchodilating agent in preclinical models. Synonyms: 1H-1,4-Diazepinium, 1,1-diethylhexahydro-4-phenyl; di-ethyl-4-phenylhomopiperazinium. Grades: >98.0%. CAS No. 1609534-88-4. Molecular formula: C15H25N2. Mole weight: 233.37. | |
| ASN-002 | ASN-002 (Gusacitinib) is a dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) with an IC50 value of 5-46 nM. It has anti-cancer activity. Synonyms: Gusacitinib. Grades: ≥98% by HPLC. CAS No. 1425381-60-7. Molecular formula: C24H28N8O2. Mole weight: 460.5. | |
| Asn(Acm)-Desmopressin | Asn(Acm)-Desmopressin is an impurity of Desmopressin, which is a synthetic octapeptide and an analog of the human hormone arginine vasopressin with antidiuretic and coagulant activities. Synonyms: deamino-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl(Acm)-L-cysteinyl-L-prolyl-D-arginyl-glycinamide (1->6)-disulfide; deamino-Cys-Tyr-Phe-Gln-Asn(Acm)-Cys-Pro-D-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6); Mpr-Tyr-Phe-Gln-Asn(Acm)-Cys-Pro-D-Arg-Gly-NH2 (Disulfide Bridge Mpr1-Cys6). Molecular formula: C49H69N15O13S2. Mole weight: 1140.30. | |
| Asoprisnil | Asoprisnil is a selective progesterone receptor (PR) modulator developed for the treatment of progesterone sensitive myomata. Synonyms: J867; J-867; J 867; Asoprisnil; Asoprisnilum. 11beta-(4-((E)-(Hydroxyimino)methyl)phenyl)-17beta-methoxy-17-(methoxymethyl)estra-4,9-dien-3-one; (8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one. Grades: 98%. CAS No. 199396-76-4. Molecular formula: C28H35NO4. Mole weight: 449.58. | |
| ASP 2535 | ASP-2535 has been found to be a GlyT1 inhibitor and brain penetrant. Synonyms: ASP-2535; ASP 2535; ASP2535; 4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole. Grades: ≥98% by HPLC. CAS No. 374886-51-8. Molecular formula: C22H18N6O. Mole weight: 382.42. | |
| Asp-26-Calcitonin | Asp-26-Calcitonin is an impurity of Calcitonin salmon, which is a calcium regulating hormone used to be an effective alternative for the treatment of postmenopausal osteoporosis. Synonyms: H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bond between Cys1 and Cys7); L-cysteinyl-L-seryl-L-asparagyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-α-aspartyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide (1->7)-disulfide. Molecular formula: C145H239N43O49S2. Mole weight: 3432.88. | |
| Asp(3)-Calcitonin | Asp(3)-Calcitonin is an impurity of Calcitonin salmon, which is a calcium regulating hormone used to be an effective alternative for the treatment of postmenopausal osteoporosis. Synonyms: H-Cys-Ser-Asp-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bond between Cys1 and Cys7); L-cysteinyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide (1->7)-disulfide. Molecular formula: C145H239N43O49S2. Mole weight: 3432.88. | |
| ASP-4000 | ASP-4000 is a dipeptidyl peptidase 4 (DPP) inhibitor with antihyperglycemic activity. Uses: Hyperlipidaemia; hyperlipoproteinaemia type iia;primary biliary cirrhosis. Synonyms: ASP4000; ASP-4000 free base; 2-Pyrrolidinecarbonitrile, 1-(((1R,3S,4S,6R)-6-hydroxy-2-azabicyclo(2.2.1)hept-3-yl)carbonyl)-, (2S)-. Grades: 98%. CAS No. 851510-67-3. Molecular formula: C12H17N3O2. Mole weight: 235.28. | |
| ASP-4000 hydrochoride | ASP-4000 is a dipeptidyl peptidase 4 (DPP) inhibitor. It has antihyperglycemic activity. Uses: Antihyperglycemic agent. Synonyms: ASP-4000 hydrochoride; ASP 4000 hydrochoride; ASP4000 hydrochoride; UNII-7393JFE67B;(2S)-1-(((1R,3S,4S,6R)-6-Hydroxy-2-azabicyclo(2.2.1)hept-3-yl)carbonyl)-2-pyrrolidinecarbonitrile hydrochloride. Grades: 98%. CAS No. 851389-35-0. Molecular formula: C12H18ClN3O2. Mole weight: 271.74. | |
| Asp(5)-AVP | Asp(5)-AVP is an impurity of Vasopressin, which is an antidiuretic hormone secreted from the posterior pituitary. Synonyms: Asp5-AVP; Asp(5)-Arg-Vasopressin; Asp(5)-Vasopressin; Vasopressin, 5-L-aspartic acid-8-L-arginine-; H-Cys-Tyr-Phe-Gln-Asp-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6); L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-aspartyl-L-cysteinyl-L-prolyl-L-arginyl-glycinamide (1->6)-disulfide. CAS No. 78031-79-5. Molecular formula: C46H64N14O13S2. Mole weight: 1085.22. | |
| Asp 5-Oxytocin | Asp 5-Oxytocin is an impurity of Oxytocin, which is a mammalian neurohypophysial hormone used as a vasodilator agent. Synonyms: L-cystyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-aspartyl-L-cystyl-L-leucyl-L-prolyl-L-glycinamide (disulfide bridge between cysteines); H-Cys-Tyr-Ile-Gln-Asp-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge: Cys1-Cys6); Oxytocin, 5-L-aspartic acid-; [5-Aspartic acid]-oxytocin; L-cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-cysteinyl-L-prolyl-L-leucyl-glycinamide (1->6)-disulfide; [Asp5]-Oxytocin. Grades: ≥95%. CAS No. 65907-78-0. Molecular formula: C43H65N11O13S2. Mole weight: 1008.18. | |
| ASP-7657 | ASP-7657 is an analgesic and anti-inflammatory agent for the treatment of diabetic neuropathies developed by Astellas Pharma. A phase I clinical trial to evaluate the safety and tolerability of single and multiple ascending oral doses of ASP7657 in healthy subjects was started in 2014 but discontinued in 2015. Uses: An analgesics and anti-inflammatories for the treatment of diabetic neuropathies. Synonyms: ASP 7657; ASP7657; trans-4-[[[[1-(2-quinolinylmethyl)-5-(trifluoromethyl)-1H-indol-7-yl]carbonyl]amino]methyl]-cyclohexanecarboxylic acid. Grades: ≥98%. CAS No. 1196045-28-9. Molecular formula: C28H26F3N3O3. Mole weight: 509.52. | |
| ASP 7663 | ASP 7663 has been found to be a TRPA1 activator and could show abdominal analgesic activities. Synonyms: ASP7663; ASP-7663; ASP 7663; (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid. Grades: ≥98% by HPLC. CAS No. 1190217-35-6. Molecular formula: C14H14FNO3. Mole weight: 263.26. | |
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