BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Ampicillin open ring dimer | An impurity of Ampicillin, an antibiotic used for the treatment of various bacterial infections. Synonyms: (4S)-2-{1-[(R)-2-amino-2-phenylacetamido]-2-[(1R)-2-{[(4S)-4-carboxy-5,5-dimethylthiazolidin-2-yl]methylamino}-2-oxo-1-phenylethylamino]-2-oxoethyl}-5,5-dimethylthiazolidine-4-carboxylic acid. Molecular formula: C31H40N6O7S2. Mole weight: 672.82. |  |
| Ampicillin sodium | Ampicillin is a beta-lactam antibiotic that is a part of the aminopenicillin family. It is mainly used for infections and sepsis of the lungs, intestines, biliary tract, urinary tract caused by sensitive bacteria. Synonyms: D-(-)-6-(2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; [2S-[2α,5α,6β(S*)]]-6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; (2S,5R,6R)-6-[[(2R)-Aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Monosodium Salt; Alpen N; Amcill S; Ampi-Dry 5000; Ampicillin Sodium; Ampicillin Sodium Salt; Ampicillin-Na; Ampicin; Anhypen; Binotal Sodium; Britapen Injection; Cilleral; D-α-Aminobenzylpenicillin Sodium Salt; Monosodium Ampicillin; Omnipen N; Pamecil; Pen A/N; Penbritin S; Pentrex; Polycillin N; Principen N; Sodium 6-(2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Benzylpenicillin Sodium; Amcill-S; Ampicillin natrium. Grades: 97%. CAS No. 69-52-3. Molecular formula: C16H18N3NaO4S. Mole weight: 371.39. | |
| Ampilloyl aminopenicillanic acid | An impurity of Ampicillin, an antibiotic used for the treatment of various bacterial infections. Synonyms: (2S,5R,6R)-6-{2-[(R)-2-Amino-2-phenylacetamido]-2-[(4S)-4-carboxy-5,5-dimethylthiazolidin-2-yl]acetamido}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. Molecular formula: C24H31N5O7S2. Mole weight: 565.66. | |
| Ampiroxicam | Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Synonyms: CP 65703; CP65703; CP-65703. Grades: >98%. CAS No. 99464-64-9. Molecular formula: C20H21N3O7S. Mole weight: 447.46. | |
| AMPK activator | AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. D942 is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels. AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, which shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 μM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. Synonyms: D942; AMPK activator; 5-[3-[4-[2- (4-Fluorophenyl) ethoxy]phenyl]propyl]furan-2-carboxylic Acid. Grades: ≥95%. CAS No. 849727-81-7. Molecular formula: C22H21FO4. Mole weight: 368.4. | |
| Ampkinone | Ampkinone, an AMPK activitor, has been found to have potential effect in the treatment of diabete and obesity. IC50: 4.3 uM(EC50). Uses: Ampkinone is an ampk activitor that has been found to have potential effect in the treatment of diabete and obesity. Synonyms: 2-(4-Benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethyl-[1]Benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dione. Grades: 98%. CAS No. 1233082-79-5. Molecular formula: C31H23NO6. Mole weight: 505.52. | |
| AMPPD | AMPPD is a sensitive fluorogenic substrate for alkaline phosphatase. It is mainly used for immunodetection, such as tumor markers, infectious diseases, endocrine function, hormones and other aspects of the diagnosis. Synonyms: 3-[2-spiroadamatane]-4-methoxy-4-[3-phosphoryloxy]-phenyl-1,2-dioxetane; 3-(4'-Methoxyspiro[adamantane-2,3'-[1,2]dioxetan]-4'-yl)phenyl dihydrogen phosphate; 3-(2'-Spiroadamantane)-4-methoxy-4-(3''-phosphoryloxy)phenyl-1,2-dioxetane; 4-Methoxy-4-(3-phosphatephenyl)spiro(1,2-dioxetane)-3,2'-adamantane; 3-(4-Methoxyspiro(1,2-dioxetane-3,2'-tricyclo(3.3.1.1(3,7))decan)-4-yl)phenyl phosphate; Lumigen PPD. Grades: ≥98% by HPLC. CAS No. 122341-56-4. Molecular formula: C18H23O7P. Mole weight: 382.34. | |
| Amprolium | Amprolium, a thiamine derivative, could be commonly useful in poultry as a coccidiostat. Uses: Amprolium could be commonly useful in poultry as a coccidiostat. Synonyms: Amprolium; Amprolio; Amprolium[ban:inn]; Amprolium [INN-Latin]; Amprolio [INN-Spanish]. Grades: 98%. CAS No. 121-25-5. Molecular formula: C14H19ClN4. Mole weight: 278.78. | |
| AMRI-59 | AMRI-59 is a potent inhibitor of PrxI with anti-tumor activity. Synonyms: 4-(4-(1H-pyrrol-1-yl)benzyl)-N-(3-acetylphenyl)piperidine-1-carboxamide. CAS No. 923515-92-8. Molecular formula: C25H27N3O2. Mole weight: 401.50. | |
| Amsalog | Asulacrine isethionate is the isethionate salt of an amsacrine analogue with antineoplastic properties. Asulacrine inhibits the enzyme topoisomerase ll, thereby blocking DNA replication and RNA and protein synthesis. Synonyms: Asulacrine isethionate; CI-921. CAS No. 80841-48-1. Molecular formula: C26H30N4O8S2. Mole weight: 590.67. | |
| amsilarotene | Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity. TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. Synonyms: TAC-101; TAC 101; TAC101; Am 555S; Benzoic acid, 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-. Grades: 99%. CAS No. 125973-56-0. Molecular formula: C20H27NO3Si2. Mole weight: 385.61. | |
| AMTB hydrochloride | The hydrochloride salt form of AMTB, which has been found to be a TRPM8 channel blocker. Synonyms: N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 926023-82-7. Molecular formula: C23H26N2O2S.HCl. Mole weight: 430.99. | |
| Amthamine dihydrobromide | Amthamine dihydrobromide is the dihydrobromide salt of amthamine, which is a highly selective histamine H2 receptor agonist. It is a weak antagonist at H3 and has no activity at H1 receptors. It decreases myogenic tone and induces vasodilation of cerebral arteries in vitro. It can be used in the suppression of the release of serotonin and H2 receptor-mediated eosinophil peroxidase (EPO). It has been used to study the effect of mast cells on T regulatory cell function. Synonyms: 5-(2-Aminoethyl)-4-methylthiazol-2-amine Dihydrobromide; A 4730 Dihydrobromide; 2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide; 2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide. Grades: ≥99% by HPLC. CAS No. 142457-00-9. Molecular formula: C6H13N3SBr2. Mole weight: 319.06. | |
| AMT-NHS | AMT-NHS is an RNA-protein crosslinker that can be used to capture different RNA-protein interactions in cells. AMT-NHS consists of a psoralen derivative and an N-hydroxysuccinimide ester group that reacts with the RNA bases and primary amines of proteins, respectively. AMT-NHS can penetrate living yeast cells and cross-link Cbf5 to H/ACA snoRNAs with high specificity. AMT-NHS induces different cross-linking patterns and targets both single-stranded and double-stranded regions of RNA. Synonyms: 2,5-dioxopyrrolidin-1-yl 3-(((2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)methyl)thio)propanoate. Molecular formula: C22H21NO7S. Mole weight: 443.47. | |
| Amylin (1-13) (human) | Amylin (1-13) (human) does not form fibrils, and this region may be involved in amylin binding to the membranes. Synonyms: Diabetes-Associated Peptide (1-13) (human); H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-OH (Disulfide bridge: Cys2-Cys7); L-lysyl-L-cysteinyl-L-asparagyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanine (2->7)-disulfide; Islet Amyloid Polypeptide (1-13) (human); DAP (1-13) (human); Insulinoma Amyloid Peptide (1-13) (human); IAPP 1-13. Grades: ≥95% by HPLC. CAS No. 198328-30-2. Molecular formula: C54H95N19O19S2. Mole weight: 1378.58. | |
| Amylin (14-20) (human) | The formation of amyloid deposits by IAPP can play a central role in the pathogenesis of type 2 diabetes. In addition to the amyloidogenic 20-29 region, the NFLVHSS domain (IAPP 14-20) tends to aggregate and seems to be involved in plaque formation. Synonyms: H-Asn-Phe-Leu-Val-His-Ser-Ser-OH; L-asparagyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-serine; (2S,5S,8S,11S,14S,17S,20S)-8-((1H-imidazol-4-yl)methyl)-20,22-diamino-17-benzyl-2,5-bis(hydroxymethyl)-14-isobutyl-11-isopropyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18-hexaazadocosan-1-oic acid. Grades: ≥95%. CAS No. 121341-77-3. Molecular formula: C36H54N10O11. Mole weight: 802.89. | |
| Amylin (20-29) (human) | Amylin (20-29) (human) forms fibrils ultrastructurally identical to amyloid fibrils seen in pancreatic islets. The region SNNFGAILSS appears to be the most important amyloidogenic sequence of hIAPP (human islet amyloid polypeptide). Synonyms: H-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-OH; L-seryl-L-asparagyl-L-asparagyl-L-phenylalanyl-glycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-serine; Amylin Fragment 20-29 human; Diabetes Associated Peptide Fragment 20-29 human; hIAPP 20-29. Grades: 95%. CAS No. 118068-30-7. Molecular formula: C43H68N12O16. Mole weight: 1009.07. | |
| Amylin, amide, rat acetate | Amylin, amide, rat acetate is a potent and high-affinity ligand for the AMY1 and AMY3 receptors and variably of AMY2 receptors. Synonyms: H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2.CH3CO2H (Disulfide bridge: Cys2-Cys7); L-lysyl-L-cysteinyl-L-asparagyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparagyl-L-phenylalanyl-L-leucyl-L-valyl-L-arginyl-L-seryl-L-seryl-L-asparagyl-L-asparagyl-L-leucyl-glycyl-L-prolyl-L-valyl-L-leucyl-L-prolyl-L-prolyl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide (2->7)-disulfide acetic acid; Amylin (rat) acetate; Rat amylin acetate; Rat amylin amide acetate; Rat islet amyloid polypeptide acetate. Grades: ≥95%. Molecular formula: C169H276N52O55S2. Mole weight: 3980.45. | |
| Amylin (free acid) (human) | Synonyms: IAPP (free acid) (human); H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-OH (Disulfide bridge: Cys2-Cys7). Grades: ≥95%. CAS No. 121381-06-4. Molecular formula: C165H260N50O56S2. Mole weight: 3904.32. | |
| Amylin (human) | Amylin, islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone secreted by pancreatic β-cells. It inhibits insulin-stimulated glucose uptake, delays gastric emptying and promotes satiety. It has glucose lowering effects in vivo. It is also used to study the mechanisms of amyloid deposition and its role in molecular misfolding processes expecially in conditions such as diabetes type II. Synonyms: L-Tyrosinamide, L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-, cyclic (2?7)-disulfide; AC 001; Amlintide; Amylin (human clone WO2013/156594-SEQID-1); Diabetes-associated peptide (human); Human amylin; Human IAPP; Human islet amyloid peptide; Human islet amyloid polypeptide; Human islet amyloid polypeptide-NH2; Islet amyloid polypeptide (human); H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge: Cys2-Cys7). Grades: 95%. CAS No. 122384-88-7. Molecular formula: C165H261N51O55S2. Mole weight: 3903.33. | |
| Amyloid β-Peptide (1-43) (human) | Amyloid β-Peptide (1-43) (human) is the minor component of neuritic plaques, which is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. It is neurotrophic and neurotoxic. Synonyms: β-Amyloid (1-43); Amyloid β-Protein Fragment 1-43; H-DL-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-D-Glu-D-Asp-D-Val-Gly-D-Ser-D-Asn-D-Lys-Gly-D-Ala-D-xiIle-D-xiIle-Gly-D-Leu-D-Met-D-Val-Gly-Gly-D-Val-D-Val-D-xiIle-D-Ala-D-xiThr-OH. CAS No. 134500-80-4. Molecular formula: C207H318N56O62S. Mole weight: 4615.19. | |
| Amyloid beta-peptide (25-35) 2TFA | Amyloid beta-peptide (25-35) 2TFA, the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, is functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease. Synonyms: GSNKGAIIGLM 2TFA; H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH.2TFA; glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionine trifluoroacetic acid; Amyloid β-peptide (25-35) trifluoroacetate; Aβ25-35 trifluoroacetate; Eledoisin, 1-glycine-2-L-serine-3-L-asparagine-5-glycine-7-L-isoleucine-11-L-methionine-, trifluoroacetate; Human β-amyloid peptide (25-35) trifluoroacetate; β-Amyloid fragment(25-35) trifluoroacetate; β-Amyloid peptide(25-35) trifluoroacetate. Grades: ≥95%. Molecular formula: C49H83F6N13O18S. Mole weight: 1288.32. | |
| Amyloid β-Protein 10-20 acetate | Amyloid β-Protein (10-20) acetate is a fragment of Amyloid β peptide that may be used in the study of neurological diseases. Synonyms: H-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-OH.CH3CO2H; L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanine acetic acid. Grades: ≥95%. Molecular formula: C73H103N17O18. Mole weight: 1506.65. | |
| Amyloid β-Protein (1-12) | Synonyms: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valine. Grades: ≥95%. CAS No. 142047-91-4. Molecular formula: C61H85N17O23. Mole weight: 1424.45. | |
| Amyloid β-Protein (11-42) | Synonyms: β Amyloid (11-42); H-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH; L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine. Grades: ≥95%. CAS No. 157802-70-5. Molecular formula: C152H244N40O42S. Mole weight: 3335.87. | |
| Amyloid β-Protein (1-24) | Synonyms: β-Amyloid (1-24); H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valine. Grades: ≥95%. CAS No. 138648-77-8. Molecular formula: C130H183N35O40. Mole weight: 2876.05. | |
| Amyloid β-Protein (1-37) | Amyloid β-Protein (1-37) is a fragment of amyloid β-protein cleaved from amyloid precursor protein (APP) that is moderately associated with Mini-Mental State Examination (MMSE) scores in Alzheimer disease. Synonyms: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycine. Grades: ≥90%. CAS No. 186359-67-1. Molecular formula: C182H274N50O55S. Mole weight: 4074.55. | |
| Amyloid β-Protein (1-39) | Synonyms: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-OH. Grades: ≥95%. CAS No. 115427-62-8. Molecular formula: C189H286N52O57S. Mole weight: 4230.73. | |
| Amyloid β-Protein (1-40) amide | Synonyms: β-Amyloid (1-40), amide; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-NH2. Grades: ≥95%. CAS No. 203460-31-5. Molecular formula: C194H296N54O57S. Mole weight: 4328.88. | |
| Amyloid β-Protein (1-40)-Lys(biotinyl) amide | Amyloid β-Protein (1-40)-Lys(biotinyl) amide is used for immobilization of Aβ40. The biotinylation of the peptide and the location of the biotin portion (N- or C-terminus) seem to influence aggregation behavior. Similar effects are observed at the N- or C-terminal of Aβ42 biotinylation. Synonyms: Abeta (1-40) Lys (Biotin) amide; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Lys(biotinyl)-NH2. Grades: ≥95%. Molecular formula: C210H322N58O60S2. Mole weight: 4683.35. | |
| Amyloid β-Protein (1-42)-Lys(biotinyl) amide | Amyloid β-Protein (1-42)-Lys(biotinyl) amide is used for immobilization of Aβ42. N-terminal biotinylated and C-terminal biotinylated Aβ42 binding may behave differently on surfaces. Synonyms: Beta-Amyloid (1-42)-Lys(biotin) amide; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-Lys(biotinyl)-NH2. Grades: ≥95%. Molecular formula: C219H338N60O62S2. Mole weight: 4867.53. | |
| Amyloid β-Protein (1-42) (scrambled) | Amyloid β-Protein (1-42) (scrambled) is the inactive control for Aβ1-42. Synonyms: β-Amyloid (1-42) Scrambled; H-Ala-Ile-Ala-Glu-Gly-Asp-Ser-His-Val-Leu-Lys-Glu-Gly-Ala-Tyr-Met-Glu-Ile-Phe-Asp-Val-Gln-Gly-His-Val-Phe-Gly-Gly-Lys-Ile-Phe-Arg-Val-Val-Asp-Leu-Gly-Ser-His-Asn-Val-Ala-OH. Grades: ≥95%. CAS No. 1678415-52-5. Molecular formula: C203H311N55O60S. Mole weight: 4514.10. | |
| Amyloid β-Protein (1-6) | The experiments using sub-peptides of Aβ42 reveals that the epitope identified by antibody A8 is located in the 1-6 region of A&beta. Synonyms: H-Asp-Ala-Glu-Phe-Arg-His-OH; L-α-Aspartylalanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidine; H-DAEFRH-OH. Grades: ≥95%. CAS No. 214550-64-8. Molecular formula: C33H47N11O11. Mole weight: 773.79. | |
| Amyloid β-Protein (16-22) | Amyloid β-Protein (16-22) is a self-assembling Aβ sequence. Synonyms: H-Lys-Leu-Val-Phe-Phe-Ala-Glu-OH; L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-glutamic acid. Grades: ≥95%. CAS No. 153247-41-7. Molecular formula: C43H64N8O10. Mole weight: 853.02. | |
| Amyloid β-Protein (1-6) amide | Experiments using sub-peptides of Aβ42 show that the epitope identified by antibody A8 is located in the 1-6 region of A&beta. Synonyms: L-Histidinamide, L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-; H-Asp-Ala-Glu-Phe-Arg-His-NH2; H-DAEFRH-NH2; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidinamide. Grades: ≥95%. CAS No. 903883-21-6. Molecular formula: C33H48N12O10. Mole weight: 772.81. | |
| Amyloid β-Protein (17-40) | Cleavage of APP by alpha- and gamma-secretase (i.e. the non-amyloidogenic pathway) yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. P3 is a major component of diffuse plaques observed in AD brains and preamyloid plaques in patients with Down syndrome. Synonyms: β-Amyloid (17-40); H-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valine; Amyloid β-Protein Fragment 17-40. Grades: ≥90%. CAS No. 156790-69-1. Molecular formula: C110H178N26O31S. Mole weight: 2392.85. | |
| Amyloid β-Protein (17-42) | Amyloid β-Protein (17-42) is the cleavage of APP by α- and γ-secretase (i.e. the non-amyloidogenic pathway) to produce P3 peptide, a mixture of Aβ 17-40 and Aβ 17-42. Aβ 17-42 contains two hydrophobic patches (L17-A21 and A30-A42) and a turn region (E22-G29), which are critical in determining aggregation and toxicity and form the strand-loop-strand conformation in the fibrils. Synonyms: H-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH; beta-Amyloid peptide 17-42; L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine; Aβ 17-42. Grades: ≥90%. CAS No. 155178-13-5. Molecular formula: C119H194N28O33S. Mole weight: 2577.08. | |
| Amyloid β-Protein (33-42) | Amyloid β-Protein (33-42) is a partial sequence of β-amyloid protein, which is used to raise antibodies against Aβ 1-42. Synonyms: APP770 (704-713); H-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH; glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine; L-Alanine, glycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-; β-Amyloid (33-42). Grades: ≥95% by HPLC. CAS No. 178949-81-0. Molecular formula: C41H74N10O11S. Mole weight: 915.15. | |
| Amyloid β-Protein (3-40) | Synonyms: β-Amyloid (3-40); H-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH. Grades: ≥95%. CAS No. 157884-70-3. Molecular formula: C187H285N51O54S. Mole weight: 4143.63. | |
| Amyloid β-Protein (3-42) | With the development of AD, N-terminal truncation of Aβ42 may be formed in increased amounts. Amyloid β-Protein (3-42) is a precursor of Pyr-peptide. The resistance of (Pyr3)-Aβ 3-42 positive plaque to age-dependent degradation may be due to its high stability and aggregation tendency. Synonyms: Aβ (3-42); H-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH. Grades: ≥95%. CAS No. 157884-74-7. Molecular formula: C196H301N53O56S. Mole weight: 4327.94. | |
| Amyloid β-Protein (40-1) | Amyloid β-Protein (40-1) is an inactive control of Amyloid β-Protein (1-40). Synonyms: β-Amyloid (40-1); H-Val-Val-Gly-Gly-Val-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-Val-Asp-Glu-Ala-Phe-Phe-Val-Leu-Lys-Gln-His-His-Val-Glu-Tyr-Gly-Ser-Asp-His-Arg-Phe-Glu-Ala-Asp-OH; L-valyl-L-valyl-glycyl-glycyl-L-valyl-L-methionyl-L-leucyl-glycyl-L-isoleucyl-L-isoleucyl-L-alanyl-glycyl-L-lysyl-L-asparagyl-L-seryl-glycyl-L-valyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alanyl-L-phenylalanyl-L-phenylalanyl-L-valyl-L-leucyl-L-lysyl-L-glutaminyl-L-histidyl-L-histidyl-L-valyl-L-alpha-glutamyl-L-tyrosyl-glycyl-L-seryl-L-alpha-aspartyl-L-histidyl-L-arginyl-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-aspartic acid. Grades: ≥95%. CAS No. 144409-99-4. Molecular formula: C194H295N53O58S. Mole weight: 4329.86. | |
| Amyloid β-Protein (4-42) | Amyloid β-Protein (4-42) is one of the earliest and most prominent Aβ species deposited in AD brain. In familial AD patients with V261I PS1 mutation, it was found to be a component of cotton boll plaques. It has also been found in amyloid deposits in vascular dementia and familial Danish dementia patients. These results suggest that Aβ 4-42 May be involved in the development of various CNS diseases. Synonyms: Aβ (4-42); H-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH. Grades: ≥95%. CAS No. 157884-72-5. Molecular formula: C191H294N52O53S. Mole weight: 4198.82. | |
| Amyloid β-Protein (5-42) | Amyloid β-Protein (5-42), produced by caspase acting on amyloid precursor proteins, deposits in the alzheimer's brain but less prone to aggregation. Synonyms: Aβ (5-42); H-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH. Grades: ≥95% by HPLC. CAS No. 1678415-97-8. Molecular formula: C182H285N51O52S. Mole weight: 4051.64. | |
| Amyloid β-Protein Fragment 35-25 | Amyloid β-Protein Fragment 35-25, the reverse sequence of Aβ 25-35, serves as an inactive control. Synonyms: H-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-OH; Amyloid β-Protein (35-25); β-Amyloid (35-25); L-methionyl-L-leucyl-glycyl-L-isoleucyl-L-isoleucyl-L-alanyl-glycyl-L-lysyl-L-asparagyl-L-seryl-glycine. Grades: ≥95%. CAS No. 147740-73-6. Molecular formula: C45H81N13O14S. Mole weight: 1060.27. | |
| Amyloid Bri Protein Precursor277 (89-106) | Synonyms: H-Cys-Gly-Ile-Lys-Tyr-Ile-Lys-Asp-Asp-Val-Ile-Leu-Asn-Glu-Pro-Ser-Ala-Asp-OH; L-cysteinyl-glycyl-L-isoleucyl-L-lysyl-L-tyrosyl-L-isoleucyl-L-lysyl-L-alpha-aspartyl-L-alpha-aspartyl-L-valyl-L-isoleucyl-L-leucyl-L-asparagyl-L-alpha-glutamyl-L-prolyl-L-seryl-L-alanyl-L-aspartic acid. Grades: ≥95% by HPLC. CAS No. 1802078-21-2. Molecular formula: C87H141N21O30S. Mole weight: 1993.24. | |
| AN-207 | AN-207, a new targeted cytotoxic analog of LH-RH. AN-207 consists of the agonist [D-Lys(6)]LH-RH linked to 2-pyrrolino-doxorubicin, an intensely potent derivative of doxorubicin. Targeted chemotherapy with AN-207 could be considered for treatment of advanced prostate cancer. Synonyms: AN-207; AN 207; AN207. CAS No. 79910-83-9. | |
| AN2718 | AN2718, a novel boron-containing small molecule, is a member of a new class of antifungals, benzoxaboroles, which inhibit fungal growth by blocking protein synthesis. Initial data have suggested that it may be more effective than tavaborole for T. rubrum and T. mentagrophytes. Synonyms: 5-chlorobenzo[c][1,2]oxaborol-1(3H)-ol; AN2718; AN-2718; AN 2718. CAS No. 174672-06-1. Molecular formula: C7H6BClO2. Mole weight: 168.38. | |
| AN-7 | AN-7 is a novel histone deacetylase inhibitor (HDACI) with anticancer activity in several cell lines. Synonyms: 3-(5-[1,2]dithiolan-3yl-pentanoylamino)-propyl]-amide. CAS No. 691410-93-2. Molecular formula: C19H34N2O2S4. Mole weight: 450.73. | |
| ANA-12 | ANA-12 is a selective TrkB antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Synonyms: ANA12; ANA 12; ANA-12. Grades: >98%. CAS No. 219766-25-3. Molecular formula: C22H21N3O3S. Mole weight: 407.49. | |
| ANA-773 | ANA773 is a Toll-like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration, ANA773 is metabolized into its active form that binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity. Synonyms: ANA773; ANA 773; RG-7795. CAS No. 1174920-78-5. Molecular formula: C12H14N4O5S. Mole weight: 326.33. | |
| Anabasine | Anabasine is an alkaloid found as a minor component in tobacco (Nicotiana). Anabasine is a nicotinic receptor agonist. Uses: Insecticides. Synonyms: (-)-Anabasine; (S)-3-(Piperidin-2-yl)pyridine; Neonikotin; Anabasin; Neonicotine; L-3-(2'-Piperidyl)pyridine. CAS No. 494-52-0. Molecular formula: C10H14N2. Mole weight: 162.23. | |
| Anabasine hydrochloride | Anabasine is a natural, nicotine-related alkaloid, which is first isolated from plants of the genus Nicotiana. Anabasine binds the same receptor as nicotine, the nicotinic acetylcholine α4β2 subtype with Ki of 38 nM and increases nicotine-induced hyperactivity, sensitization, and intravenous self-administration. Anabasine inhibits aromatase and nicotinic acetylcholine receptors (nAChRs) and may produce a depolarizing neuromuscular junction (NMJ) block. Anabasine can also be used as a clinical biomarker for tobacco smoke exposure. Additionally, anabasine is teratogenic and may be used as an insecticide. Synonyms: (S)-3-(2-piperidinyl)-pyridine hydrochloride; 3-(2S)-2-Piperidinyl-pyridine hydrochloride. Grades: ≥95%. CAS No. 15251-47-5. Molecular formula: C10H14N2·xHCl. Mole weight: 162.2. | |
| Anacardic acid triene | Anacardic acid is a blanket term applied to a family of closely related compounds consisting of salicylic acid with a 15-carbon alkyl chain, which exist either in a fully saturated form or as a monoene, diene, or triene. Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. Anacardic acid triene inhibits NADH oxidase with IC50 of 1.3 μg/ml, which is an enzyme involved in bacterial respiration. Anacardic acid triene is molluscicidal, inducing toxicity in B. glabrata (LC50 = 0.35 ppm), but is inactive against S. mansoni parasites. Synonyms: Anacardic Acid 15:3. Grades: ≥98%. CAS No. 103904-73-0. Molecular formula: C22H30O3. Mole weight: 342.47. | |
| Anagrelide Hydrochloride | Anagrelide is a drug used for the treatment of essential thrombocytosis,or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. Uses: Platelet aggregation inhibitors. Synonyms: Anagrelide hydrochloride; BL 4162A; BL-4162A; BL4162A; Agrylin; Xagrid; GALE-401; Thromboreductin. Grades: >98%. CAS No. 58579-51-4. Molecular formula: C10H7Cl2N3O.HCl. Mole weight: 292.55. | |
| Anatalline | Anatalline is a tobacco plant alkaloid. Synonyms: rac Anatalline (cis/trans mixture); Pyridine, 3,3'-(2,4-piperidinediyl)bis-; 2,4-di(3-pyridyl)piperidine. CAS No. 1189431-36-4. Molecular formula: C15H17N3. Mole weight: 239.32. | |
| Anavex 2-73 HCl | Anavex 2-73 is a mixed muscarinic and sigma-1/σ1 Receptor agonist with neuroprotective effects. Synonyms: Blarcamesine hydrochloride; AVex-73 hydrochloride; AE-37 hydrochloride. CAS No. 195615-84-0. Molecular formula: C19H24ClNO. Mole weight: 317.85. | |
| Anaxirone | Anaxirone is a synthetic triepoxide alkylating agent with potential antineoplastic activity. Anaxirone alkylates DNA via actual or derived epoxide groups, resulting in inhibition of DNA synthesis. Uses: Antineoplastic agents. Synonyms: triglycidylurazol; Abbreviation: TGU; 1,2,4-triglycidylurazol. CAS No. 77658-97-0. Molecular formula: C11H15N3O5. Mole weight: 269.25. | |
| Andarine | Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, tissue-selective for anabolic organs. Synonyms: GTx-007; GTx007; GTx 007; S-4; S4; S 4; Andarine. Grades: >98%. CAS No. 401900-40-1. Molecular formula: C19H18F3N3O6. Mole weight: 441.36. | |
| Androgen receptor antagonist 1 | Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50 = 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47% AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively. Synonyms: Androgen receptor antagonist 1; 1338812-36-4; CHEMBL1916251; SCHEMBL17941138; SCHEMBL17947423; BDBM50356995; AKOS040732433; MS-27273; HY-130992; CS-0120091; N-[3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-1-(2-hydroxyethyl)pyrazole-4-carboxamide. Grades: 99%. CAS No. 1338812-36-4. Molecular formula: C21H25ClN4O3. Mole weight: 416.90. | |
| Androst-5-en-17-one | Androst-5-en-17-one (CAS# 25824-80-0 ) is a useful research chemical. Synonyms: 3-Deoxydehydroepiandrosterone; 10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one; (8R,9S,10R,13S,14S)-10,13-Dimethyl-3,4,7,8,9,10,11,12,13,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17(2H)-one. Grades: 95 %. CAS No. 25824-80-0. Molecular formula: C19H28O. Mole weight: 272.42. | |
| Anemarsaponin B | Anemarsaponin B could inhibit PAF-induced rabbitplatelet aggregation in vitro. Synonyms: Timosaponin B-?; (8xi,9xi,14xi)-26-(beta-D-glucopyranosyloxy)furost-20(22)-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-galactopyranoside. Grades: >98%. CAS No. 139051-27-7. Molecular formula: C45H74O18. | |
| Anethole trithione | Anethole trithione is a antitumor agent used in the treatment of dry mouth. Uses: Eczema, protecting liver and promote digestion. Synonyms: 5-(4-Methoxyphenyl)-1,2-dithiole-3-thione; 5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione. Grades: >98%. CAS No. 532-11-6. Molecular formula: C10H8OS3. Mole weight: 240.35. | |
| Angelic acid | Angelic acid is a natural compound isolated from Angelica sinensis. It shows sedative and psychotropic properties. Synonyms: 2-Methylisocrotonic acid; (Z)-2-methylbut-2-enoic acid; (2Z)-2-methylbut-2-enoic acid. Grades: 98%. CAS No. 565-63-9. Molecular formula: C5H8O2. Mole weight: 100.12. | |
| Angelic anhydride | Angelic anhydride is a natural compound isolated from Angelica sinensis. Synonyms: (Z)-2-Methylbut-2-enoic anhydride; 2-Methylisocrotonic Anhydride. Grades: 98%. CAS No. 94487-74-8. Molecular formula: C10H14O3. Mole weight: 182.2. | |
| Angelol K | Angelol K is a coumarin isolated from Angelica pubescens. It shows significant activity on human platelet aggregation. Synonyms: [(1S,2S)-2,3-dihydroxy-1-(7-methoxy-2-oxochromen-6-yl)-3-methylbutyl] (Z)-2-methylbut-2-enoate. Grades: 0.98. CAS No. 169736-93-0. Molecular formula: C20H24O7. Mole weight: 376.15. | |
| Angiotensin 1/2 (1-9) TFA | Angiotensin 1/2 (1-9) TFA contains the amino acids 1-9 that are converted from Angiotensin I/II peptide. It is an anti-cardiac hypertrophy drug with the functions of human metabolite, rat metabolite, antihypertensive agent and cardiac protective agent. Synonyms: Angiotensin I (1-9) TFA; Angiotensin I (1-9) trifluoroacetate; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH.TFA; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidine trifluoroacetic acid; 5-L-Isoleucine-1-9-angiotensin I trifluoroacetate; 1-9-(5-Ile)-Angiotensin trifluoroacetate; 1-9-Angiotensin I (human) trifluoroacetate. Grades: ≥95%. Molecular formula: C58H79F3N16O15. Mole weight: 1297.36. | |
| Angiotensin 1/2 (5-7) acetate | The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I is hydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. Molecular formula: C19H31N5O6. Mole weight: 425.49. | |
| Angiotensin 1/2 + A (2-8) Acetate | Angiotensin A is a potent endogenous vasoconstrictor octapeptide. It is a derivative of angiotensin II (Ang II) that differs from Ang II in having alanine instead of aspartic acid as the first amino acid. It shows similar affinity for AT1 and AT2 receptors as angiotensin II with Ki values of 1.6 and 2.3 nM in vitro. Molecular formula: C51H75N13O12. Mole weight: 1062.22. | |
| Angiotensin Fragment 1-7 acetate | Angiotensin Fragment 1-7 is a major active component of the renin-angiotensin system (RAS), produced from cleavage of Ang II by angiotensin-converting-enzyme type 2 (ACE2). Angiotensin 1-7 inhibits purified canine ACE activity with IC50 of 0.65 μM. This peptide can be generated by the action of ACE2, a homolog of ACE, on angiotensin II or by the action of neprilysin on angiotensin I. It has been studied in the context of ameliorating the symptoms of metabolic syndrome. Synonyms: 5-L-isoleucine-1-7-angiotensin II; Ang-(1-7). Grades: ≥95%. Molecular formula: C41H62N12O11·xC2H4O2. Mole weight: 899. | |
| Angiotensin I (1-9) | Angiotensin I (1-9) is a 9-amino acid peptide formed when Angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy-terminal leucine of Angiotensin I. It is an anti-cardiac hypertrophy drug with the functions of human metabolite, rat metabolite, antihypertensive agent and cardiac protective agent. Synonyms: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidine; L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His. Grades: ≥95% by HPLC. CAS No. 34273-12-6. Molecular formula: C56H78N16O13. Mole weight: 1183.32. | |
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