BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AG1295 | Tyrphostin AG 1295 is a selective inhibitor of PDGFR (platelet-derived growth factor receptor) protein tyrosine kinase (PDGF-receptor PTK)(IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 μM) in Swiss/3T3 cells. Synonyms: AG1295; AG 1295; AG 1295; NSC 380341; NSC380341; NSC-380341; Tyrphostin AG 1295. Grades: >98%. CAS No. 71897-07-9. Molecular formula: C16H14N2. Mole weight: 234.30. |  |
| AG-14361 | AG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells. Synonyms: AG14361; AG-14361; AG 14361. Grades:>98%. CAS No. 328543-09-5. Molecular formula: C19H20N4O. Mole weight: 320.39. | |
| AG-1557 hydrochloride | AG-1557 hydrochloride is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Synonyms: AG 1557 hydrochloride; AG1557 hydrochloride. Molecular formula: C16H15ClIN3O2. Mole weight: 443.66. | |
| AG 205 | AG 205 is a progesterone receptor membrane component 1 (Pgrmc1) ligand. It inhibits cell cycle progression and cell viability in cancer cell lines. It inhibits progesterone induced cytosolic Ca2+ increases in GnRH neurons in vitro. Synonyms: Cis-2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-ethanone. Grades: ≥98%. CAS No. 442656-02-2. Molecular formula: C22H23ClN6OS. Mole weight: 454.98. | |
| Agaritine Monohydrate | Agaritine is an aromatic hydrazine-derivative mycotoxin in mushroom species of the genus Agaricus. Synonyms: 5-Hydroxy-5-{[4-(hydroxymethyl)phenyl]hydrazono}-L-norvaline hydrate (1:1); L-Norvaline, 5-hydroxy-5-[2-[4- (hydroxymethyl) phenyl]hydrazinylidene]-, hydrate (1:1); β-N-[γ-L(+)-Glutamyl]-4-hydroxymethylphenylhydrazine hydrate; 5-[2-(α-Hydroxy-p-tolyl)hydrazide]-L-glutamic Acid hydrate; N2-(γ-glutamyl)-4-hydroxymethylphenylhydrazine hydrate; Agaritine hydrate. Grades: ≥95%. Molecular formula: C12H17N3O4.H2O. Mole weight: 285.30. | |
| Agarotetrol | Agarotetrol is found from the herbs of Aquilaria sinensis. Synonyms: Agarotetrol (AHl). Grades: > 95%. CAS No. 69809-22-9. Molecular formula: C17H18O6. Mole weight: 318.32. | |
| AGB1 | AGB1, a potent, fast and highly selective bump-and-hole (B&H)-PROTAC degrader for BromoTag, exhibits degradation of Ab:Brd4BD2 L387A and Ab: BromoTag-Brd2 with pDC50s of 7.8 and 7.9, respectively. It has binary affinity for VHL (Kd = 125 nM), and has good pharmacokinetic characteristics in mice with a DC50 (6h) of ~13 nM. Synonyms: (S)-13-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoate. Grades: ≥95%. CAS No. 2776190-62-4. Molecular formula: C51H63ClN8O9S2. Mole weight: 1031.68. | |
| AGI-5198 | AGI-5198 is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM. Synonyms: AGI5198; AGI-5198; AGI 5198; IDHC35; IDH-C35; IDH C35. Grades: >98%. CAS No. 1355326-35-0. Molecular formula: C27H31FN4O2. Mole weight: 462.56. | |
| AGI-6780 | AGI-6780 is an IDH2 inhibitor that potently and selectively inhibits the tumor-associated mutant IDH2/R140Q with IC50 of 23±1.7 nM. AGI-6780 is less potent against IDH2WT with IC50of 190±8.1 nM. Synonyms: AGI6780; AGI 6780; AGI-6780. CAS No. 1432660-47-3. Molecular formula: C21H18F3N3O3S2. Mole weight: 481.508. | |
| AGK2 | AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM. Synonyms: AGK-2; AGK 2; 2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide. Grades: >98%. CAS No. 304896-28-4. Molecular formula: C23H13Cl2N3O2. Mole weight: 434.27. | |
| AGK7 | AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. AGK7 is an inactive control to be used in experiments with AGK2. Synonyms: SIRT2 Inhibitor (Inactive Control); 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide. Grades: ≥95%. CAS No. 304896-21-7. Molecular formula: C23H13Cl2N3O2. Mole weight: 434.3. | |
| AGL 2263 | AGL 2263 is an inhibitor of the insulin-like growth factor 1 receptor (IGF-1R; IC50 = 0.43 μM). Synonyms: (E)-2-(3,4-dihydroxybenzoyl)-3-(2-oxo-3H-1,3-benzoxazol-5-yl)prop-2-enenitrile. Grades: ≥98%. CAS No. 638213-98-6. Molecular formula: C17H10N2O5. Mole weight: 322.3. | |
| Aglafoline | Aglafoline, isolated from Aglaia elliptifolia Merr, is a selective PAF-induced platelet aggregation inhibitor. And studies have shown that because aglafoline blocked the high-K+-induced contraction of rat thoracic aorta, it may also possess Ca+- channel b. Synonyms: methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate Aglafoline Methyl rocaglate AGLAFOLIN CHEBI:65374 CMLDBU00002646 143901-35-3 methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydr. CAS No. 143901-35-3. Molecular formula: C28H28O8. Mole weight: 492.52. | |
| AGN 193109 | AGN 193109 has been found to be a pan-retinoic acid receptor (RAR) antagonist. Synonyms: AGN 193109; AGN193109; AGN-193109; 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid. Grades: ≥97% by HPLC. CAS No. 171746-21-7. Molecular formula: C28H24O2. Mole weight: 392.49. | |
| AGN 194310 | A high affinity pan-RAR antagonist (AGN194310, K(d) for binding to RARs=2-5 nM) inhibited colony formation (by 50%) by all three lines at 16-34 nM, and led to a transient accumulation of flask-cultured cells in G1 followed by apoptosis. AGN194310 is 12-22 fold more potent than all-trans retinoic acid (ATRA) against cell lines and also more potent in inhibiting the growth of primary prostate carcinoma cells. The administration of all-trans retinoic acid to VAD mice resulted in a transient reduction in NF-kappaB activity and, conversely, a single dose of the RAR-pan-antagonist, AGN 194310, administered to control mice, led to a marked, transient induction of whole-body luminescence. Mice were treated with AGN194310, a synthetic retinoid that antagonises the physiological function of the three RAR isotypes (alpha, beta, gamma) but does not interact with RXRs. Analyses of the granulocytic lineage using Gr-1, c-Kit and CD11b antibodies, demonstrated that granulocyte numbers were strikingly increased across haemopoietic compartments in all AGN194310-treated mice. A significant increase in the frequency of progenitor cells containing granulocytes was observed in the bone marrow of mice following treatment with AGN194310. Synonyms: AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310. Grades: >98%. CAS No. 229961-45-9. Molecular formula: C28H24O2S. Mole weight: 424.55. | |
| AGN 195183 | RX-195183 is an RARα agonist (Kd=3 nM) with potential antineoplastic activity, modulating the transcription of genes responsible for cell differentiation and proliferation. Uses: Rarα agonist. Synonyms: IRX5183; IRX-5183; IRX 5183; NRX195183; NRX-195183; NRX 195183; VTP-195183; VTP195183; VTP 195183; AGN-195183; AGN195183; AGN195183.; 4-[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]-2,6-difluorobenzoic acid. Grades: ≥98%. CAS No. 367273-07-2. Molecular formula: C22H22ClF2NO4. Mole weight: 437.87. | |
| AGN 196996 | AGN 196996 is a potent and selective antagonist of RAR&alpha. It has been reported to selectively bind to RARs (retinoic acid receptors) for RARα, RARβ and RAR&gamma. It can inhibit the gene transcription activity which induced by ATRA and other RAR agonists. It shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists. Grades: >98%. CAS No. 958295-17-5. Molecular formula: C24H20BrNO5. Mole weight: 482.32. | |
| AGN 203818 | AGN 203818 is an α2-adrenergic receptor antagonist that can be used to treat fibromyalgia-associated pain. Synonyms: 2H-Imidazole-2-thione, 4-[1-(2,3-dimethylphenyl)ethyl]-1,3-dihydro-, hydrochloride (1:1); 4-[1-(2,3-Dimethylphenyl)ethyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride (1:1); AGN203818; AGN-203818; AGN 203818 hydrochloride. Grades: ≥95%. CAS No. 1021954-16-4. Molecular formula: C13H16N2S.HCl. Mole weight: 268.81. | |
| AGN 205728 | AGN 205728 is a potent and selective RARγ antagonist and has no inhibiton on RARα and RAR&beta. Synonyms: AGN 205728; AGN205728; AGN-205728. Grades: >98%. CAS No. 859498-05-8. Molecular formula: C29H27NO3. Mole weight: 437.53. | |
| Agomelatine L(+)-Tartaric acid | Agomelatine L(+)-Tartaric acid is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. It is used as an antidepressant drug. It has been approved by FDA in October 2011. It has toxicities, such as Hyperhidrosis, Abdominal pain, Nausea, Vomiting, Diarrhoea, Constipation, Back pain, Fatigue and so on. Uses: Agomelatine l(+)-tartaric acid is used as an antidepressant drug. Synonyms: Acetamide, N-[2-(7-methoxy-1-naphthalenyl)ethyl]-,(2R,3R)-2,3-dihydroxybutanedioate;S-20098 L(+)-Tartaric acid. Grades: >98%. CAS No. 824393-18-2. Molecular formula: C19H23NO8. Mole weight: 393.39. | |
| Agrimol B | Agrimol B, a main active ingredient isolated from Agrimonia pilosa Ledeb, possesses insecticidal activity. Uses: Insecticidal. Synonyms: (2S)-1-[3,5-Bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-1-butanone; 1-Butanone, 1-[3,5-bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-, (2S)-. Grades: >98%. CAS No. 55576-66-4. Molecular formula: C37H46O12. Mole weight: 682.75. | |
| Agrimoniin | Agrimoniin is a natural compound which can be isolated from hairyvein agrimonia. Synonyms: α-D-Glucopyranose, cyclic 2,3:4,6-bis[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-[2-[5-[[[2,3:4,6-bis-O-[[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-diyl]dicarbonyl]-α-D-glucopyranosyl]oxy]carbonyl]-2,3-dihydroxyphenoxy]-3,4,5-trihydroxybenzoate]; α-D-Glucopyranose, cyclic 2,3:4,6-bis(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate) 1-[2-[5-[[[2,3:4,6-bis-O-[(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-diyl)dicarbonyl]-α-D-glucopyranosyl]oxy]carbonyl]-2,3-dihydroxyphenoxy]-3,4,5-trihydroxybenzoate], stereoisomer; Dibenzo[g, i]dibenzo[6', 7':8', 9'][1, 4]dioxecino[2', 3':4, 5]pyrano[3, 2-b][1, 5]dioxacycloundecin, α-D-glucopyranose deriv. Grades: 98%. CAS No. 82203-01-8. Molecular formula: C82H54O52. Mole weight: 1871.28. | |
| AH 001 | AH 001 is a potent melatonin agonist. Synonyms: AH 001; AH001; AH-001; 8-Methoxy-2-acetamidotetralin; N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide. Grades: 98%. CAS No. 80270-68-4. Molecular formula: C13H17NO2. Mole weight: 219.28. | |
| AH 11110 hydrochloride | The hydrochloride salt form of AH 11110, which is an α1B-adrenoceptor ligand and has been found to exhibit interaction with α1-adrenoceptors as well as α2-adrenoceptors. Synonyms: AH 11110 hydrochloride; AH11110 hydrochloride; AH-11110 hydrochloride; 4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride. Grades: ≥98% by HPLC. CAS No. 179388-65-9. Molecular formula: C21H26N2O2.HCl. Mole weight: 374.91. | |
| AH 7614 | AH 7614 is a FFA4/GPR120 antagonist and has been found to exhibit effects in restraining intracellular calcium accumulation induced by either linoleic acid or a FFAR4 agonist. Synonyms: AH 7614; AH7614; AH-7614; 4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide. Grades: ≥98% by HPLC. CAS No. 6326-6-3. Molecular formula: C20H17NO3S. Mole weight: 351.42. | |
| AHR Antagonist 5 | AHR Antagonist 5, an effective and orally active aromatic hydrocarbon receptor (AHR) antagonist with IC50 of less than 0.5 μM. It can significantly inhibit tumor growth in combination with the checkpoint inhibitor anti-PD-1. Synonyms: BCP33104; HY-136220; CS-0120848; (R)-N-(2-(5-Fluoropyridin-3-Yl)-8-Isopropylpyrazolo[1,5-A][1,3,5]Triazin-4-Yl)-2,3,4,9-Tetrahydro-1H-Carbazol-3-Amine Trihydrochloride. Grades: ≥98% by HPLC. CAS No. 2247953-39-3. Molecular formula: C25H27Cl3FN7. Mole weight: 550.9. | |
| AICAR phosphate | AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell. Synonyms: Acadesine phosphate; AICA Riboside phosphate. Grades: >98%. CAS No. 681006-28-0. Molecular formula: C9H17N4O9P. Mole weight: 356.23. | |
| AIDA | AIDA is a selective group I mGluR agonist and could show centrally active following systemic administration in vivo. Uses: Excitatory amino acid antagonists. Synonyms: (RS)-1-Aminoindan-1,5-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 168560-79-0. Molecular formula: C11H11NO4. Mole weight: 221.21. | |
| AIM-100 | AIM-100 is a small molecule inhibitor of Ack1. It not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase. It could suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer and suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity. Synonyms: AIM-100; AIM 100; AIM100. Grades: >98%. CAS No. 873305-35-2. Molecular formula: C23H21N3O2. Mole weight: 371.43. | |
| AITRL human | AITRL, a cytokine belonging to the tumor necrosis factor (TNF) ligand superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. AITRL is a ligand for receptor TNFRSF18/AITR/GITR. GITR/AITRL interaction plays a role in the pathogenesis of tumors, inflammation, and autoimmune diseases. In addition, AITRL is involved in endothelial cell (EC) activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). Synonyms: Activation-induced TNFR member Ligand; TNFSF18; rHuActivation-inducible TNF-related Ligand/AITRL; GITRL; TL-6; Tumor necrosis factor ligand superfamily member 18; rHuAITRL; GITR Ligand. Grades: ≥98% by HPLC. Mole weight: ~14.3 kDa. | |
| AJS75 | AJS75, the most adjuvant-active fraction of AJSt, could improve antigen-specific both cellular and humoral immune responses and simultaneously elicit a Th1/Th2 response by inducing cytokine and chemokine at the site of injection. | |
| Ajugol | Ajugol is an iridiod glucoside isolated from the roots of Rehmannia glutinosa. Uses: An iridiod glucoside. Synonyms: (2S,3S,4R,5R,6S)-2-(hydroxymethyl)-6-{[(4aS,7S,7aR)-7-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-1-yl]oxy}tetrahydro-2H-pyran-2,3,4,5-tetrol. Grades: >98%. CAS No. 52949-83-4. Molecular formula: C15H24O9. Mole weight: 348.35. | |
| AK-1 | AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor (IC50 = 12.5 μM) with excellent selectivity against SIRT1 and SIRT3 (IC50 >50 μM, and >50 μM for SIRT1 and SIRT3 respectively). Synonyms: AK-1; AK 1; AK1; DA-42784; KB-120200; Y1899; J-018989; DA42784; KB120200; J018989; DA 42784; KB 120200; J 018989; 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide; SIRT2 Inhibitor II, AK-1; SIRT2 Inhibitor II; CHEMBL1797749; 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide. CAS No. 330461-64-8. Molecular formula: C19H21N3O5S. Mole weight: 403.45. | |
| AKI-001 | AKI-001 is a potent Aurora kinase inhibitor, which exhibits low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Synonyms: AKI-001; AKI 001; AKI001. Grades:>98%. CAS No. 925218-37-7. Molecular formula: C21H24N4O. Mole weight: 348.45. | |
| Aklomide | Aklomide is antiprotozoal agent against coccidiosis. Synonyms: 2-chloro-4-nitrobenzamide 2-Chloro-4-nitrobenzamide aklomide 3011-89-0 Aklomix Clomide Alkomide Benzamide, 2-chloro-4-nitro- component of Aklomix component of Novastat-W. CAS No. 3011-89-0. Molecular formula: C7H5ClN2O3. Mole weight: 200.58. | |
| AKN-028 | AKN-028, the FLT3/KIT kinase inhibitor, is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases. Synonyms: AKN 028; AKN028; N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine; 2,3-Pyrazinediamine, N3-1H-indol-5-yl-5-(4-pyridinyl)-; N3-(1H-Indol-5-yl)-5-(4-pyridinyl)-2,3-pyrazinediamine. Grades: ≥95%. CAS No. 1175017-90-9. Molecular formula: C17H14N6. Mole weight: 302.33. | |
| AKOS B028903 | AKOS B028903 (CAS# 692275-23-3 ) is a useful research chemical. Synonyms: AKOS B028903; CHEMBRDG-BB 7420349; 2-CHLORO-5-ETHOXY-4-PROPOXY-BENZALDEHYDE; ART-CHEM-BB B028903; VITAS-BB TBB009798. Grades: 95 %. CAS No. 692275-23-3. Molecular formula: C12H15ClO3. Mole weight: 242.70. | |
| AKOS B028906 | AKOS B028906 (CAS# 692267-55-3 ) is a useful research chemical. Synonyms: AKOS B028906; CHEMBRDG-BB 7389354; 2-CHLORO-5-ETHOXY-4-ISOPROPOXY-BENZALDEHYDE; ART-CHEM-BB B028906; VITAS-BB TBB009799. Grades: 95 %. CAS No. 692267-55-3. Molecular formula: C12H15ClO3. Mole weight: 242.70. | |
| AKOS B029152 | AKOS B029152 (CAS# 700849-61-2 ) is a useful research chemical. Synonyms: AKOS B029152; CHEMBRDG-BB 7726699; 4-(5-OXO-3-PROPYL-2,5-DIHYDRO-1H-PYRAZOL-1-YL)BENZOIC ACID; 4-(5-OXO-3-PROPYL-2,5-DIHYDRO-PYRAZOL-1-YL)-BENZOIC ACID; ART-CHEM-BB B029152; VITAS-BB TBB009868. Grades: 95 %. CAS No. 700849-61-2. Molecular formula: C13H14N2O3. Mole weight: 246.26. | |
| AKOS B029817 | AKOS B029817 (CAS# 590376-72-0 ) is a useful research chemical. Synonyms: AKOS B029817; CHEMBRDG-BB 7763392; 2-(4-CHLORO-2-FORMYLPHENOXY)ACETAMIDE; ART-CHEM-BB B029817; VITAS-BB TBB002769. Grades: 95 %. CAS No. 590376-72-0. Molecular formula: C9H8ClNO3. Mole weight: 213.62. | |
| Akt-I-1,2 HCl | Akt-I-1,2 is a selective, non-ATP-competitive Akt1 and Akt2 inhibitor. Synonyms: Akt I 1,2 HCl; AktI1,2 HCl; Benzenemethanamine, alpha,alpha-dimethyl-4-(3-phenyl-2-quinoxalinyl)-, hydrochloride (1:1). CAS No. 473382-50-2. Molecular formula: C23H22ClN3. Mole weight: 375.90. | |
| Akuammidine | Cas No. 639-36-1. | |
| Akuammiline | Cas No. 1897-26-3. | |
| AL 082D06 | AL 082D06, also called as D-06, is a selective nonsteroidal antagonist of glucocorticoid receptor (GR) (Ki= 210 nM) without significant activity on AR, PR, MR and ER(Ki > 10 uM). AL 082D06 binds competitively with steroids, likely occupying a similar site. Synonyms: AL082D06; AL-082D06; AL 082D06; D-06. CAS No. 256925-03-8. Molecular formula: C23H24ClN3O2. Mole weight: 409.91. | |
| AL-3152 | AL-3152 is a aldehyde reductase inhibitors originated by Alcon. But clinical trials was discontinued for the treatment of Diabetic nephropathies, Diabetic neuropathies and Diabetic retinopathy. Uses: Diabetic nephropathies; diabetic neuropathies; diabetic retinopathy. Synonyms: AL-3152; AL 3152; AL3152; 2,7-difluoro-4-methoxy-Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione. Grades: 98%. CAS No. 126048-33-7. Molecular formula: C16H10F2N2O3. Mole weight: 316.62. | |
| AL 34662 | AL 34662 is a potent 5-HT2 receptor agonist with ocular hypotensive activity. Uses: Serotonin 5-ht2 receptor agonists. Synonyms: AL 34497; 1-((S)-2-aminopropyl)-1H-indazol-6-ol; 1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]-. Grades: ≥98%. CAS No. 210580-75-9. Molecular formula: C10H13N3O. Mole weight: 191.2. | |
| AL 8697 | AL 8697 is an effective and selective p38α inhibitor and has been found to exhibit some antiinflammatory activities. Synonyms: AL 8697; AL8697; AL-8697; N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide. Grades: ≥98% by HPLC. CAS No. 1057394-06-5. Molecular formula: C21H21F3N4O. Mole weight: 402.41. | |
| Ala (3-CN)5-Oxytocin | Ala (3-CN)5-Oxytocin is an impurity of Oxytocin, which is a mammalian neurohypophysial hormone used as a vasodilator agent. Synonyms: [Ala(3-CN)5] Oxytocin; L-cystyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-β-3-cyano-alanyl-L-cystyl-L-leucyl-L-prolyl-L-glycinamide (disulfide bridge between cysteines); Oxytocin, 5-(3-cyano-L-alanine)-; H-Cys-Tyr-Ile-Gln-Ala(3-CN)-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge: Cys1-Cys6). Grades: ≥95%. CAS No. 87590-89-4. Molecular formula: C43H64N12O11S2. Mole weight: 989.18. | |
| Alalevonadifloxacin | Alalevonadifloxacin is a quinolone antibacterial. It is a DNA gyrase and DNA topoisomerase inhibitor. Alalevonadifloxacin is potentially useful to treat bacterial Gram-positive, Gram-negative and anaerobic infections. Phase II clinical trials for the treatment of Methicillin-resistant Staphylococcus aureus infections and Skin and soft tissue infections are on-going. Uses: Methicillin-resistant staphylococcus aureus infections; skin and soft tissue infections. Synonyms: WCK2349; WCK 2349; WCK-2349; (5S)-8-[4-(L-alanyloxy)piperidin-1-yl]-9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid. Grades: 98%. CAS No. 706809-20-3. Molecular formula: C22H26FN3O5. Mole weight: 431.46. | |
| Alamandine TFA | Alamandine is a vasoactive peptide belonging to the renin-angiotensin system (RAS). It is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions. Synonyms: H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH.TFA; L-alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline trifluoroacetic acid. Grades: ≥95%. CAS No. 2863659-13-4. Molecular formula: C40H62N12O9.C2HF3O2. Mole weight: 969.02. | |
| Alanine anhydride | Alanine anhydride (CAS# 5625-46-7 ) is a useful research chemical. Synonyms: 3,6-dimethylpiperazine-2,5-dione. CAS No. 5625-46-7. Molecular formula: C6H10N2O2. Mole weight: 142.16. | |
| Alatrofloxacin Mesylate | Alatrofloxacin Mesylate is the mesylate salt form of the fluoroquinolone derivative Alatrofloxacin, a type II DNA topoisomerase inhibitor that has been developed as an antibacterial agent. Synonyms: L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, methanesulfonate (1:1); L-Alaninamide, L-alanyl-N-[(1α,5α,6α)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, monomethanesulfonate; L-Alaninamide, L-alanyl-N-[3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-, (1α,5α,6α)-, monomethanesulfonate; Adrenochrome monoaminoguanidine mesilate; CP 116517; CP 116517-27; Trovan IV; Turvel IV; 7-((1R,5S,6s)-6-((S)-2-((S)-2-aminopropanamido)propanamido)-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid compound with methanesulfonic acid (1:1). Grades: ≥95%. CAS No. 146961-77-5. Molecular formula: C27H29F3N6O8S. Mole weight: 654.61. | |
| ALB-109564 | ALB 109564(a) is a semi-synthetic derivative of the vinka alkaloid vinblastine with potential antineoplastic activity. Tubulin inhibitor ALB 109564(a) binds to tubulin monomers and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the G2/M phase of the cell cycle. Synonyms: ALB-109564; ALB 109564; ALB109564; ALB 109564(a); Vincaleukoblastine, 12'-(methylthio)-, hydrochloride (1:2). CAS No. 854756-74-4. Molecular formula: C47H60N4O9S. Mole weight: 857.07. | |
| ALB 109564(a) dihydrochloride | ALB 109564(a) is a Tubulin inhibitor as a semi-synthetic derivative of the vinka alkaloid originated by AMRI. It can bind to tubulin monomers and inhibit microtubule formation, this leads to the disruption of mitotic spindle assembly and arrest of tumor cells in the G2/M phase of the cell cycle. Phase I clinical trials for Solid tumours is on going. Uses: Solid tumours. Synonyms: ALB-109564 dihydrochloride; ALB 109564 dihydrochloride; ALB109564 dihydrochloride; Vincaleukoblastine 12(methylthio) hydrochloride (1:2);(3aR,3a1R,4R,5S,5aR,10bR)-methyl 4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-13-(methylthio)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate. Grades: 98%. CAS No. 1300114-12-8. Molecular formula: C47H60N4O9S. Mole weight: 930.00. | |
| Albaconazole | Albaconazole is a triazole antifungal agent. It shows potent activity against species of Candida, Cryptococcus and Aspergillus. Synonyms: 7-chloro-3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]quinazolin-4-one. CAS No. 187949-02-6. Molecular formula: C20H16ClF2N5O2. Mole weight: 431.8. | |
| ALBANIN F | Cas No. 75629-19-5. | |
| albutrepenonacog alfa | Albutrepenonacog alfa is a long-acting recombinant coagulation factor IX albumin fusion protein. It was approved for the treatment of hemophilia B. It can reduce the risk of bleeding episodes in patients with hemophilia B. Uses: The treatment of hemophilia b. Synonyms: Idelvion; rIX-RFP. | |
| ALC-0159 | Cas No. 1849616-42-7. | |
| ALC-0315 | Cas No. 2036272-55-4. | |
| Alcohols, C16-18 and C18-unsatd | Alcohols, C16-18 and C18-unsatd is an emollient that enhances penetration into skin. CAS No. 68002-94-8. | |
| Alda 1 | ALDH2 is the activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). Uses: Activator of aldehyde dehydrogenase 2 (aldh2). Synonyms: Alda-1; Alda1; Alda 1. N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide. Grades: ≥98%. CAS No. 349438-38-6. Molecular formula: C15H11Cl2NO3. Mole weight: 324.16. | |
| Aldehyde Reactive Probe (trifluoroacetate salt) | Aldehyde Reactive Probe is a biotinylated-aminooxy form of biotin that can used for the detection and quantification of AP sites in damaged DNA. Synonyms: N-(Aminooxyacetyl)-N'-(D-biotinoyl)hydrazine, trifluoroacetic acid salt; ARP. CAS No. 627090-10-2. Molecular formula: C14H22F3N5O6S. Mole weight: 445.41. | |
| Aldometanib | Aldometanib is an active aldolase inhibitor. It prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AMPK. Aldometanib can be used for the research of metabolic homeostasis. Grades: >98.0%. CAS No. 2904601-67-6. Molecular formula: C27H43Cl2IN2. Mole weight: 593.46. | |
| Aldose reductase-IN-1 | Aldose reductase-IN-1, an aldose reductase inhibitor, could have potential biological usage in the study of breast cancer. IC50: 28.9 pM. Uses: Aldose reductase-in-1 is an aldose reductase inhibitor that could have potential biological usage in the study of breast cancer. Synonyms: Aldose reductase-IN-1; SCHEMBL359604; CS-5128; HY-18967; AT-001; CS 5128; HY 18967; AT 001; CS5128; HY18967; AT001. Grades: 98%. CAS No. 1355612-71-3. Molecular formula: C17H10F3N5O3S. Mole weight: 421.35. | |
| ALE-0540 | ALE-0540 is a novel nonpeptidic molecule that inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors. Synonyms: 1H-Benz(de)isoquinoline-1,3(2H)-dione, 2-((2-hydroxyethyl)amino)-5-nitro-. Grades: >95.0%. CAS No. 234779-34-1. Molecular formula: C14H11N3O5. Mole weight: 301.26. | |
| Alfuzosin | Alfuzosin is a pharmaceutical drug of the alpha-1 blocker class. It works by relaxing the muscles in the prostate and bladder neck. It is used to treat benign prostatic hyperplasia (BPH). It offers an alternative to prostatectomy in patients who require surgery but are unfit for this treatment, and in patients requiring symptomatic relief while awaiting surgery. It is marketed in the United States by Sanofi Aventis under the brand name Uroxatral. It was approved by the FDA for treatment of BPH in June 2003. It has been approved the listing. Uses: Alfuzosin is used to treat benign prostatic hyperplasia (bph). Synonyms: Alfuzosina; Alfuzosine; Xatral; 2-Furancarboxamide, N-[3-[ (4-amino-6, 7-dimethoxy-2-quinazolinyl) methylamino]propyl]tetrahydro-; N-[3-[N- (4-Amino-6, 7-dimethoxyquinazolin-2-yl) -N- (methyl) amino]propyl]tetrahydrofuran-2-carboxamide; SL 77499; SL77499; SL-77499; Alfuzosinum. Grades: 99%. CAS No. 81403-80-7. Molecular formula: C19H27N5O4. Mole weight: 389.45. | |
| Aliconazole | An antifungal azole derivative. Synonyms: 1-[(Z)-2-(4-chlorophenyl)-3-(2,4-dichlorophenyl)prop-2-enyl]imidazole. CAS No. 63824-12-4. Molecular formula: C18H13Cl3N2. Mole weight: 363.67. | |
| Alirocumab | Cas No. 1245916-14-6. | |
| Alisporivir | Alisporivir, also known as DEB-025, a non-immunosuppressive cyclosporine A derivative, is acyclophil ininhibitor molecule with potent anti-hepatitis C virus (HCV) activity. Treatment with alisporivir alone or combined with PEGylated IFNalpha2a reduced the viral load in patients with chronic HCV infection. Synonyms: cyclo[Abu-N(Me)D-Ala-Xaa-Val-N(Me)Leu-Ala-D-Ala-N(Me)Leu-N(Me)Leu-N(Me)Val-N(Me)Bmt(E)]; (3S, 6S, 9S, 12R, 15S, 18S, 21S, 24S, 27R, 30S, 33S)-25, 30-diethyl-33-[(E, 1R, 2R)-1-hydroxy-2-methylhex-4-enyl]-1, 4, 7, 10, 12, 15, 19, 27, 28-nonamethyl-6, 9, 18-tris(2-methylpropyl)-3, 21, 24-tri(propan-2-yl)-1, 4, 7, 10, 13, 16, 19, 22, 25, 28, 31-undecazacyclotritriacontane-2, 5, 8, 11, 14, 17, 20, 23, 26, 29, 32-undecone; alisporivir; DEBIO-025; MeAla(3)EtVal(4)-cyclosporin; UNIL 025; UNIL-025; UNIL025. Grades: 98.15%. CAS No. 254435-95-5. Molecular formula: C63H113N11O12. Mole weight: 1216.64. | |
| Alizapride | Alizapride is a dopamine antagonist. It has prokinetic and antiemetic effects and is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. It is structurally related to metoclopramide and other benzamides. It has been listed. Uses: Alizapride has prokinetic and antiemetic effects and is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. Synonyms: N-(1-allyl-2-pyrrolidinylmethyl)-6-methoxy-1h-benzotriazole-5-carboxamide;1H-benzotriazole-5-carboxamide,6-methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)met;6-Methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-1h-benzotriazole-5-carbo;6-Methoxy-N-{[1-(2-propny. Grades: 98%. CAS No. 59338-93-1. Molecular formula: C16H21N5O2. Mole weight: 315.37. | |
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