BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AD57 hydrochloride | AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer. Grades: ≥98%. Molecular formula: C22H20F3N7O·HCl. Mole weight: 491.9. |  |
| Adalimumab | Cas No. 331731-18-1. | |
| Adamantane-1,3,5,7-tetraol | Adamantane-1,3,5,7-tetraol is an impurity of Vildagliptin. It is an oral anti-hyperglycemic agent (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Synonyms: Vildagliptin Impurity 28. Grades: ≥95%. CAS No. 16104-28-2. Molecular formula: C10H16O4. Mole weight: 200.23. | |
| Adapalene sodium salt | Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR). It is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is possibly more effective than tretinoin 0.025% gel in the treatment of acne vulgaris. Synonyms: CD 271 sodium salt; Differin sodium salt; 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid sodium salt; 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid sodium salt; Sodium 6-[3-(adamantan-1-yl)-4-methoxyphenyl]-2-naphthoate; 2-Naphthalenecarboxylic acid, 6-(4-methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-, sodium salt (1:1). Grades: >98%. CAS No. 911110-93-5. Molecular formula: C28H27NaO3. Mole weight: 434.50. | |
| Adaphostin | Adaphostin is a p210bcr/abl tyrosine kinase inhibitor with IC50 value of 14 μM. It shows anti-proliferative activity in human prostate cancer cell line PC-3, leukemia models and other cancer cell lines. It is a potent inducer of myeloid cell death. It could induce a degradation of WT and mutated Bcr/Abl and induce apoptosis in tumor cells. It shows selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro. It is used as a novel antitumor agent. Synonyms: 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoic acid tricyclo[3.3.1.13,7]dec-1-yl ester; AG 957 Adamantyl Ester; NSC 680410; AG957 Adamantyl Ester; NSC680410; AG-957 Adamantyl Ester; NSC-680410. Grades: ≥98% by HPLC. CAS No. 241127-58-2. Molecular formula: C24H27NO4. Mole weight: 393.48. | |
| Adarotene | Adarotene is an atypical retinoid and a promising anti-tumour agent with selective apoptotic activity on the leukaemic blast. The anti-tumour activity of the compound has been associated with its capacity to induce DNA double stranded breaks. Synonyms: ST1926; ST 1926; ST-1926. Grades: 0.98. CAS No. 496868-77-0. Molecular formula: C25H26O3. Mole weight: 374.47. | |
| Adefovir disoproxil | Adefovir disoproxil is an impurity of Tenofovir Disoproxil Fumarate, which is a potent reverse transcriptase inhibitor used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. Synonyms: O,O-Bis(isopropoxycarbonyloxymethyl) [(6-amino-9H-purin-9-yl)ethyloxy]methylphosphonate; Desmethyl Tenofovir Disoproxil; 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-, bis(1-methylethyl) ester, 5-oxide; ( ( (2- (6-amino-9H-purin-9-yl)ethoxy)methyl)phosphoryl)bis (oxy)bis (methylene) isopropyl dicarbonate; [2- (6-aminopurin-9-yl) ethoxymethyl- (isopropoxycarbonyloxymethoxy) phosphoryl]oxymethyl isopropyl carbonate; [[2-(6-Amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid bis[(isopropoxycarbonyloxy)methyl] ester. Grades: ≥95%. CAS No. 365417-53-4. Molecular formula: C18H28N5O10P. Mole weight: 505.42. | |
| Adefovir disoproxil fumarate | Adefovir disoproxil fumarate is an impurity of Tenofovir Disoproxil Fumarate, which is a potent reverse transcriptase inhibitor used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. Synonyms: Desmethyl Tenofovir Disoproxoil Fumarate; 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-, 1,9-bis(1-methylethyl) ester, 5-oxide, (2E)-2-butenedioate (1:1); 5-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]-2,4,6,8-Tetraoxa-5-phosphanonanedioic Acid Bis(1-methylethyl) Ester 5-Oxide Fumarate; ( ( ( (2- (6-amino-9H-purin-9-yl)ethoxy)methyl)phosphoryl)bis (oxy))bis (methylene) diisopropyl bis(carbonate) fumarate. Grades: ≥95%. CAS No. 2251049-67-7. Molecular formula: C18H28N5O10P.C4H4O4. Mole weight: 621.49. | |
| Adenine hydrochloride (1:x) | Adenine HCl is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. Synonyms: Adenine hydrochloride; 2922-28-3; 6-Aminopurine hydrochloride; 7H-purin-6-amine hydrochloride; ADENINE HCL; Adenine monohydrochloride; 1H-Purin-6-amine, monohydrochloride; 9H-Purin-6-amine, hydrochloride (1:1); Leucon; Adenine (hydrochloride); 22177-51-1; 1H-Purin-6-amine, hydrochloride; CHEMBL539503; 7H-purin-6-amine; hydrochloride; 9H-purin-6-amine hydrochloride; 364H11M7OD; MFCD00075782; 6-Aminopurine (hydrochloride); Vitamin B4 (hydrochloride); Adeninehydrochloride; 1H-Adenine hydrochloride; UNII-364H11M7OD; 1h-purin-6-amine monohydrochloride. CAS No. 22177-51-1. Molecular formula: C5H5N5.xHCl. Mole weight: 135.128 (free base). | |
| Adenine monohydrochloride | Adenine HCl is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry. Synonyms: Adenine hydrochloride; 6-Aminopurine hydrochloride. Grades: > 98 %. CAS No. 2922-28-3. Molecular formula: C5H5N5.HCl. Mole weight: 171.59. | |
| Adenine phosphate salt | Adenine phosphate salt (CAS# 70700-30-0 ) is a useful research chemical. Synonyms: phosphoric acid;7H-purin-6-amine. CAS No. 70700-30-0. Molecular formula: C5H8N5O4P. Mole weight: 233.12. | |
| Adenine sulfate | Cas No. 321-30-2. | |
| (-)-Adenosine 3'-monophosphate hydrate | (-)-Adenosine 3'-monophosphate hydrate is a crucial molecule in biomedicine used to study cellular signaling processes. It serves as a precursor for the synthesis of adenosine triphosphate (ATP) and acts as a potent vasodilator. This compound plays a vital role in the treatment of heart diseases, such as angina pectoris, because of its ability to regulate blood flow. Its hydrate form ensures stability and efficient delivery in scientific research and pharmaceutical applications. Synonyms: adenosine 3'-monophosphate hydrate; (2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate hydrate; DTXSID10871566; [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate; hydrate; AKOS015855366; (-)-Adenosine 3'-monophosphate hydrate, 99%; (2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydro-3-furanyl dihydrogen phosphate hydrate (1:1); (2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yldihydrogenphosphatehydrate; {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}phosphonic acid hydrate; 6199-71-9. CAS No. 699012-36-7. Molecular formula: C10H16N5O8P. Mole weight: 365.24. | |
| Adenosine 5'-diphosphate, periodate oxidized sodium salt | Adenosine 5'-diphosphate, periodate oxidized sodium salt (CAS# 71997-39-2 ) is a useful research chemical. Synonyms: sodium;[[(2S)-2-[(1R)-1-(6-aminopurin-9-yl)-2-oxoethoxy]-3-oxopropoxy]-hydroxyphosphoryl] hydrogen phosphate. CAS No. 71997-39-2. Molecular formula: C10H13N5O10P2. Mole weight: 425.19. | |
| Adenosine dialdehyde | Adenosine dialdehyde is an irreversible inhibitor of S-adenosylhomocysteine hydrolase (IC50 = 40 nM), blocking the conversion of SAH to homocysteine and adenosine. Synonyms: 2-[1-(6-aminopurin-9-yl)-2-oxoethoxy]-3-hydroxypropanal. Grades: ≥ 95 %. CAS No. 34240-05-6. Molecular formula: C10H11N5O4. Mole weight: 265.23. | |
| Aderbasib | Aderbasib is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. Synonyms: INCB7839; INCB 7839; INCB-7839; INCB007839; INCB 007839; INCB-007839. CAS No. 791828-58-5. Molecular formula: C21H28N4O5. Mole weight: 416.48. | |
| Adipamide | Adipamide (CAS# 628-94-4) is a useful research chemical. Synonyms: hexanediamide. Grades: 98 %. CAS No. 628-94-4. Molecular formula: C6H12N2O2. Mole weight: 144.17. | |
| Adipic acid monoethyl ester | Adipic acid monoethyl ester (CAS# 626-86-8) is used in the selection of streptavidin binder from DNA-encoded chemical library. Reagent in the synthetic preparation of colchicine-SAHA hybrids as antitumor agents. Synonyms: 6-ethoxy-6-oxohexanoic acid. Grades: 95 %. CAS No. 626-86-8. Molecular formula: C8H14O4. Mole weight: 174.19. | |
| adipiplon | Adipiplon is GABAA receptor partial agonist. It can bind to the α3 subtype. Adipiplon is one of the first drugs selected for clinical development which is able to discriminate between α2 and α3, as well as showing little affinity for the α1 or α5 subtypes.Adipiplon is being researched as a potential medication for the treatment of anxiety and insomnia, and in 2008 it was being used in Phase IIb trials. But these trials were suspended after next-day side effects were discovered. Uses: Anxiety and insomnia. Synonyms: NG2-73; NG 2-73; NG-2-73; NG273; NG 273; NG-273; Adipiplon;7-((2-(3-fluoropyridin-2-yl)-1H-imidazol-1-yl)methyl)-2-methyl-8-propyl-[1,2,4]triazolo[1,5-c]pyrimidine. Grades: 98%. CAS No. 840486-93-3. Molecular formula: C18H18FN7. Mole weight: 351.39. | |
| AdipoRon hydrochloride | AdipoRon hydrochloride is the hydrochloride salt and water-soluble derivative of AdipoRon, which is a potent and selective agonist of adiponectin receptors AdipoR1 and AdipoR2 with Kd values of 1.8 and 3.1 μM respectively. It activates PPAR-α and AMPK pathways in the liver and muscle. It ameliorates dyslipidemia, insulin resistance and glucose intolerance in db/db mice. It is a promising treatment for obesity-related diseases such as type 2 diabetes. It is orally active antidiabetic agent. Synonyms: 2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1781835-20-8. Molecular formula: C27H29N2O3Cl. Mole weight: 464.98. | |
| Adipotide Acetate | Adipotide is a prototype in a new class of candidate drugs that may be useful for treating obesity in humans. Synonyms: FTPP (Fat Targeted Proapoptotic Peptide) Acetate. Molecular formula: C113H210N36O30S2. Mole weight: 2617.23. | |
| Adjudin | Adjudin, formerly called as AF-2364, an analog of lonidamine, attenuates microglia activation by suppression of the NF-κB pathway. Adjudin has potent anti-spermatogenic activity in animals. Synonyms: 1-[(2,4-dichlorophenyl)methyl]indazole-3-carbohydrazide1-(2,4-dichlorobenzyl)indazole-3-carbohydrazideadjudinAF-2364AF2364; AF 2364. CAS No. 252025-52-8. Molecular formula: C15H12Cl2N4O. Mole weight: 335.19. | |
| Adjuvant Peptide | Adjuvant Peptide is an immunomodulatory factor that can be used as a vaccine adjuvant to enhance immune response. It inhibits HIV replication in CD4+H9 lymphocytes. Uses: Adjuvants, immunologic. Synonyms: D-α-Glutamine, N-(N-acetylmuramoyl)-L-alanyl-; D-α-Glutamine, N2-[N-(N-acetylmuramoyl)-L-alanyl]-; N-(N-Acetylmuramoyl)-L-alanyl-D-α-glutamine; Acetylmuramoyl-L-alanyl-D-isoglutamine; MDP; MDP-D; Muramoyl dipeptide; N-(Acetylmuramoyl)-L-alanyl-D-isoglutamine; N-(Acetylmuramoyl)alanyl-D-isoglutamine; N-Acetylmuramoyl dipeptide; N-Acetylmuramoyl-L-alanine-D-isoGln; N-Acetylmuramoylalanyl-D-isoglutamine; (4R,5R,7R,10S,13R)-13-carbamoyl-4-formyl-7,10-dimethyl-2,8,11-trioxo-5-((1R,2R)-1,2,3-trihydroxypropyl)-6-oxa-3,9,12-triazahexadecan-16-oic acid; N-Ac-Mur-Ala-D-Glu-NH2; N-Acetylmuramyl-L-Ala-D-Glu-NH2; Muramyl dipeptide. Grades: ≥95%. CAS No. 53678-77-6. Molecular formula: C19H32N4O11. Mole weight: 492.48. | |
| ADL5859 HCl | ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel. Synonyms: A35957, RU2267; ADL5859 HCl; A 35957, RU 2267; ADL 5859 HCl; A-35957, RU-2267; ADL-5859 HCl. Grades: >98%. CAS No. 850173-95-4. Molecular formula: C24H29ClN2O3. Mole weight: 428.95. | |
| Adomeglivant | Adomeglivant has been found to be a glucagon receptor antagonist that could probably be effective for both type-I and type-II diabetes mellitus. Synonyms: Adomeglivant; LY-2409021; Adomeglivant [USAN]; UNII-74Z5ZL2KVG; LY2409021; LY 2409021; 3- [ [4- [ (1S) -1- [4- (4-tert-butylphenyl) -3, 5-dimethylphenoxy] -4, 4, 4-trifluorobutyl] benzoyl] amino] propanoic acid. Grades: 98%. CAS No. 1488363-78-5. Molecular formula: C32H36F3NO4. Mole weight: 555.64. | |
| Adoprazine | Adoprazine, also known as SLV 313, with potential antipsychotic property, is a agonist of cloned h5-HT(1A) receptors (pEC(50)=9.0) and a full antagonist of hD(2) (pA(2)=9.3) and hD(3) (pA(2)=8.9) receptors. Synonyms: 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]piperazine 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-((5-(4-fluorophenyl)-3-pyridinyl)methyl)piperazine SLV 313 SLV-313 SLV313. Grades: 95%. CAS No. 222551-17-9. Molecular formula: C24H24FN3O2. Mole weight: 405.46. | |
| Adrenocorticotropic Hormone Fragment 1-16 human, rat | ACTH (1-16) is an agonist of the melanocortin-1 and 3 receptors (K1 = 0.267 ± 0.116 and 19.0 ± 4.3 nmol/L respectively). Synonyms: ACTH (1-16) (human); H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-OH. CAS No. 5576-42-1. Molecular formula: C89H133N25O22S. Mole weight: 1937.23. | |
| Adrenocorticotropic Hormone Fragment 7-38 human | Synonyms: Corticostatin; (7-28)-Corticotropin; Acth(7-38); CIP peptide. CAS No. 68563-24-6. Molecular formula: C167H257N47O46. Mole weight: 3659.11. | |
| Adrenomedullin (porcine) | Synonyms: ADM (porcine); H-Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 (Disulfide bridge: Cys16-Cys21); Adrenomedullin (1-52), porcine. Grades: ≥95%. CAS No. 912862-96-5. Molecular formula: C262H403N79O76S3. Mole weight: 5971.77. | |
| Adrenomedullin (rat) | Adrenomedullin (rat), a synthetic rat adrenomedullin (rADM), induces a potent and sustained hypotensive activity in anesthesized rats. Synonyms: ADM (1-50) (rat); H-Tyr-Arg-Gln-Ser-Met-Asn-Gln-Gly-Ser-Arg-Ser-Thr-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Met-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Met-Ala-Pro-Arg-Asn-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 (Disulfide bridge: Cys14-Cys19). Grades: ≥95%. CAS No. 161383-47-7. Molecular formula: C242H381N77O75S5. Mole weight: 5729.49. | |
| Adrenorphin TFA | Adrenorphin TFA is an opioid octapeptide that acts as an agonist of μ-opioid receptor with a Ki of 12 nM. Synonyms: Adrenorphin (human), trifluoroacetate (salt); L-Tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valinamide trifluoroacetate; Adrenorphin (ox) trifluoroacetat; BAM 8 trifluoroacetate; Metaphinamide trifluoroacetate; Metorphamide trifluoroacetate; Metorphamide (ox) trifluoroacetate; Metorphinamide trifluoroacetate; H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2.TFA; Adrenorphin 3TFA. Grades: ≥95%. Molecular formula: C46H70F3N15O11S. Mole weight: 1098.22. | |
| Adropin (34-76) (human, mouse, rat) | Adropin, a secreted factor involved in energy homeostasis and lipid metabolism, is encoded by the energy homeostasis-related gene (Enho) and expressed in the liver and brain. In diet-induced obesity (DIO) mice, adropin (34-76) reduced hepatosteatosis and insulin resistance, regardless of obesity or food intake. In addition, adropin could be a regulator of endothelial function. Synonyms: H-Cys-His-Ser-Arg-Ser-Ala-Asp-Val-Asp-Ser-Leu-Ser-Glu-Ser-Ser-Pro-Asn-Ser-Ser-Pro-Gly-Pro-Cys-Pro-Glu-Lys-Ala-Pro-Pro-Pro-Gln-Lys-Pro-Ser-His-Glu-Gly-Ser-Tyr-Leu-Leu-Gln-Pro-OH (Disulfide bridge: Cys1-Cys23); L-Cysteinyl-L-histidyl-L-seryl-L-arginyl-L-seryl-L-alanyl-L-alpha-aspartyl-L-valyl-L-alpha-aspartyl-L-seryl-L-leucyl-L-seryl-L-alpha-glutamyl-L-seryl-L-seryl-L-prolyl-L-asparaginyl-L-seryl-L-seryl-L-prolylglycyl-L-prolyl-L-cysteinyl-L-prolyl-L-alpha-glutamyl-L-lysyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-glutaminyl-L-lysyl-L-prolyl-L-seryl-L-histidyl-L-alpha-glutamylglycyl-L-seryl-L-tyrosyl-L-leucyl-L-leucyl-L-glutaminyl-L-proline cyclic (1?23)-disulfide. Grades: ≥95%. CAS No. 1802086-30-1. Molecular formula: C190H293N55O68S2. Mole weight: 4499.82. | |
| Aducanumab | Aducanumab is a human monoclonal antibody targeting amyloid-β (Aβ). Aducanumab has been approved for the treatment of Alzheimer's disease (AD). Synonyms: BIIB037. CAS No. 1384260-65-4. | |
| ADU-S100 ammonium salt | ML RR-S2 CDA ammonium salt is an inducer of stimulator of interferon genes (STING). It can increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP, indicating the ML enhances its action at human STING. Synonyms: MIW815 ammonium salt; ML RR-S2 CDA ammonium salt; [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'?5')-adenosine, cyclic nucleotide, diammonium salt; STING Inducer-1. Grades: 98%. CAS No. 1638750-96-5. Molecular formula: C20H30N12O10P2S2. Mole weight: 724.6. | |
| ADU-S100 disodium salt | ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulator of interferon genes (STING) for treating cancer. Synonyms: MIW815 disodium salt; ML RR-S2 CDA disodium salt; 2',3'-c-di-AM(PS)2 (Rp,Rp); Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'?5')-, cyclic nucleotide, sodium salt (1:2); ADU-S 100; MIW 815. Grades: 98%. CAS No. 1638750-95-4. Molecular formula: C20H22N10Na2O10P2S2. Mole weight: 734.51. | |
| ADW742 | NVP-ADW742 is a novel small weight molecular inhibitor of IGF-IR with potential anticancer activity. NVP-ADW742 inhibited IGF-IR-mediated proliferation with an IC50 of 11.12 μmol/l. NVP-ADW742 induced early suppression of Akt, P38 and GSK-3β phosphorylation. NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells. Synonyms: NVP-ADW742; NVP ADW-742; NVP ADW 742; ADW 742; ADW-742; ADW742; GSK 552602A; GSK-552602A; GSK552602A. Grades: 0.98. CAS No. 475488-23-4. Molecular formula: C28H31N5O. Mole weight: 453.59. | |
| ADX 10059 hydrochloride | The hydrochloride salt form of ADX 10059, which has been reported to be a negative allosteric modulator. Synonyms: ADX-10059 Hydrochloride; ADX10059 Hydrochloride; ADX 10059 Hydrochloride; ADX10059 HCl; 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine hydrochloride. Grades: ≥99% by HPLC. CAS No. 757949-98-7. Molecular formula: C15H13FN2.HCl. Mole weight: 276.74. | |
| ADX-47273 | ADX-47273 is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5. Synonyms: TKI-258 Dilactic Acid; TKI 258 Dilactic Acid; TKI258 Dilactic Acid; ADX-47273; ADX 47273; ADX47273. Grades: >98%. CAS No. 851881-60-2. Molecular formula: C20H17F2N3O2. Mole weight: 369.36. | |
| AE-37 | Cas No. 195615-83-9. | |
| AEG 3482 | AEG 3482 has been found to be an inhibitor of c-jun N-terminal kinase (JNK) signaling and could probably be useful against some neurological disorders. Synonyms: AEG-3482; AEG 3482; AEG3482; 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide. Grades: ≥99% by HPLC. CAS No. 63735-71-7. Molecular formula: C10H8N4O2S2. Mole weight: 280.33. | |
| AEG40826 | AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. Synonyms: HGS-1029; HGS 1029; HGS1029; AEG40826-2HCl; AEG-40826; HGS1029; AEG 40826. Grades: 98%. CAS No. 1107664-44-7. | |
| Aegelinol | Aegelinol is a coumarin isolated from Angelica gigas. Synonyms: (±)-Prantschimgin; 3',4'-dihydro-3'-hydroxy-Xanthyletin. Grades: 0.98. CAS No. 5993-18-0. Molecular formula: C14H14O4. Mole weight: 246.3. | |
| Aerothionin | Aerothionin is a dimeric spiroisoxazoline derived from marine sponges that demonstrates antimycobacterial activity. Synonyms: (+)-aerothionin. Grades: ≥97%. CAS No. 28714-26-3. Molecular formula: C24H26Br4N4O8. Mole weight: 818.1. | |
| AES-350 | AES-350 is an effective and orally active HDAC6 inhibitor with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 shows higher HDAC isoform selectivity, higher MV4-11 cell cytotoxicity, improved treatment window and more effective absorption through cells and lipid membranes. Synonyms: Tert-Butylbenzamido Hydroxylbenzamide. Grades: 98%. CAS No. 847249-57-4. Molecular formula: C18H20N2O3. Mole weight: 312.4. | |
| Aescin IIA | anti-inflammatory. Uses: Anti-inflammatory. Synonyms: escin IIa; AESCIN IIA. Grades: >98%. CAS No. 158732-55-9. Molecular formula: C54H84O23. Mole weight: 1101.25. | |
| AescinIIB | anti-inflammatory. Uses: Anti-inflammatory. Synonyms: AESCIN IIB; ESCIN IIB. Grades: >98%. CAS No. 158800-83-0. Molecular formula: C54H84O23. Mole weight: 1101.25. | |
| AEW-541 | AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP-AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application. Synonyms: NVP-AEW541; NVP-AEW 541; NVP-AEW-541; AEW-541; AEW 541; AEW541. Grades: 0.98. CAS No. 475489-16-8. Molecular formula: C27H29N5O. Mole weight: 439.563. | |
| AEZS-108 | AEZS-108, also known as AN-152 or zoptarelin doxorubicin, is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation. Synonyms: AEZS 108; AEZS108; AN 152; AN-152; AN152; Zoptarelin doxorubicin; Zoptrex; Lys(6)-LHRH-doxorubicin. Grades: 98%. CAS No. 139570-93-7. Molecular formula: C91H117N19O26. Mole weight: 1893.01. | |
| AEZS-112 | AEZS-112, also known as ZEN012, is an orally active small mol. anti-cancer drug which inhibits the polymn. of tubulin at low micromolar concns. AEZS 112 dose-dependently increased non-vital hypodiploid cells and the cytotoxic effect was least pronounced in G2 phase of the cell cycle. AEZS 112 showed anti-tumor activity in human ovarian and endometrial cancer cell lines at low micromolar concns., which could not be abrogated by caspase inhibition and is therefore a good candidate for in vivo studies in these tumors. Synonyms: ZEN012; ZEN 012; ZEN-012; AEZS 112; AEZS112. Grades: 98%. CAS No. 1214741-69-1. Molecular formula: C25H23N3O2. Mole weight: 397.47. | |
| AF 12198 acetate | AF 12198 acetate is a potent, selective human type I IL-1 receptor antagonist. Synonyms: N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate; Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2.CH3CO2H; (N-(N-acetyl-L-phenylalanyl-L-alpha-glutamyl-L-tryptophyl-L-threonyl-L-prolyl-glycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl)-(2S)-azetidine-2-carbonyl)-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate. Grades: ≥95%. Molecular formula: C98H127N19O24. Mole weight: 1955.17. | |
| AF430 NHS ester | AF430 is a dye. The fluorophore is hydrophilic. It is used in flow cytometry and other applications.,The NHS ester functional group allows to conjugate the fluorophore efficiently with primary and secondary amine groups in both aqueous buffers and anhydrous conditions. Grades: NMR 1H, HPLC-MS (95%). CAS No. 467233-94-9. Molecular formula: C32H42N3F3O9S. Mole weight: 701.75. | |
| AF594 activated ester, 5-isomer | AF594 is a bright water-soluble dye that is not sensitive to pH changes within the range from 4 to 10. This red-fluorescent dye is the best alternative to Texas Red, so it is commonly used for flow cytometry and fluorescent microscopy.,AF594 activated ester is used for labeling proteins, peptides, antibodies, and any molecules containing an -NH2 group (such as amino-modified oligonucleotides); it results in the formation of stable amide bonds between the dye and the target molecule. The best result in conjugation reaction achieved at pH from 7 to 9.,AF594 can be used for protein labeling with a high molar dye-to-protein ratio. The resulting conjugates with a high degree of labeling (DOL) do not exhibit significant fluorescence quenching. In contrast, the conjugates have brighter fluorescence, which allows increasing the lowest limit of detection of the labeled product. Grades: NMR 1H, HPLC-MS (95%). CAS No. 1638544-48-5. Molecular formula: C51H67N5O13S2. Mole weight: 1022.23. | |
| AF-DX 116 | AF-DX 116 has been found to be a selective mAChR M2 antagonist. Synonyms: Otenzepad; AF-DX 116; AF-DX-116; AF-DX116; 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one. Grades: ≥98% by HPLC. CAS No. 102394-31-0. Molecular formula: C24H31N5O2. Mole weight: 421.54. | |
| AF-DX 384 | AF-DX 384 has been found to be a mAChR M2/M4 selective antagonist. Uses: Parasympatholytics. Synonyms: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide. Grades: ≥98% by HPLC. CAS No. 118290-26-9. Molecular formula: C27H38N6O2. Mole weight: 478.64. | |
| AFG206 | AFG206 is the novel first-generation "type II" FLT3 inhibitor. Synonyms: AFG-206; AFG 206. Grades: >98%. CAS No. 630122-37-1. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
| AFG210 | AFG210 is a novel first-generation "type II" FLT3 inhibitor. Synonyms: AFG 210; AFG-210; 1-(3-(trifluoromethyl)phenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea. Grades: >98%. CAS No. 228400-22-4. Molecular formula: C19H14F3N3O2. Mole weight: 373.33. | |
| Afimoxifene | Afimoxifene (4-hydroxytamoxifen) is a selective estrogen receptor modulator which is the active metabolite of tamoxifen. Afimoxifene is a transdermal gel formulation and is being developed by Ascend Therapeutics, Inc. under the trademark TamoGel. Afimoxifene has completed a phase II clinical trial for the treatment of cyclical mastalgia. Uses: Estrogen antagonists. Synonyms: (E/Z)-4-Hydroxytamoxifen; 4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; TamoGel; Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-. Grades: ≥95%. CAS No. 68392-35-8. Molecular formula: C26H29NO2. Mole weight: 387.51. | |
| Afloqualone | Afloqualone is a agonist of GABA receptor has sedative and muscle-relaxant effects. Uses: A agonist of gaba receptor. Synonyms: HQ-495; HQ495; HQ 495. Afloqualone; 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one. Grades: ≥98%. CAS No. 56287-74-2. Molecular formula: C16H14FN3O. Mole weight: 283.3. | |
| AFN-1252 | AFN-1252 is an enoyl-(acyl-carrier protein) reductase fabl inhibitor, inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml. Uses: Antibacterial. Synonyms: AFN-1252; AFN 1252; AFN1252; AFN-12520000; API-1252; Debio-1452; AFN12520000; API1252; Debio1452. (E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-3-yl)prop-2-enamide. Grades: ≥95%. CAS No. 620175-39-5. Molecular formula: C22H21N3O3. Mole weight: 375.43. | |
| AFP-464 | AFP-464 is a synthetic lysyl prodrug of the amino-substituted flavone derivate aminoflavone with antiproliferative and antineoplastic activities. AFP464 is rapidly converted to aminoflavone in plasma. Aminoflavone activates the aryl hydrocarbon receptor (AhR) signaling pathway leading to an increase in cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1A2 (CYP1A2) expression and, to a lesser extent, an increase in cytochrome P450 1B1 (CYP1B1) expression. Synonyms: AFP464; AFP 464; Hexanamide, 2,6-diamino-N-(4-(5-amino-6,8-difluoro-7-methyl-4-oxo-4H-1-benzopyran-2-yl)-2-fluorophenyl)-, (2S)-. CAS No. 468719-52-0. Molecular formula: C23H27F3N4O6S. Mole weight: 448.44. | |
| Afrormosin | Afrormosin is found in the herbs of Mucuna macrocarpa Wallich. Synonyms: Afrormosine. Grades: > 95%. CAS No. 550-79-8. Molecular formula: C17H14O5. Mole weight: 298.29. | |
| AG-012917 | AG-012917 is a broad spectrum cyclin-dependent kinase inhibitor with potential anticancer activity. Synonyms: AG 012917; AG012917; (S)-4-((4-amino-5-(2,6-difluorobenzoyl)thiazol-2-yl)amino)-N-((1-methylpyrrolidin-2-yl)methyl)benzamide. Grades: >98%. CAS No. 486414-16-8. Molecular formula: C23H23F2N5O2S. Mole weight: 471.52. | |
| AG-012986 | AG-012986 is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 showed antiproliferative activities in vitro with IC(50)s of <100 nmol/L in 14 of 18 tumor cell lines. In vivo, significant antitumor efficacy induced by AG-012986 was seen (tumor growth inhibition,>83.1%) in 10 of 11 human xenograft tumor models. AG-012986 also showed dose-dependent retinoblastoma Ser(795) hypophosphorylation, cell cycle arrest, decreased Ki-67 tumor staining, and apoptosis in conjunction with antitumor activity. Synonyms: AG 012986; AG012986; Benzamide, 4-((4-amino-5-(2,6-difluorobenzoyl)-2-thiazolyl)amino)-N-((1R)-2-(dimethylamino)-1-methylethyl)-. Grades: >98%. CAS No. 486414-35-1. Molecular formula: C22H23F2N5O2S. Mole weight: 459.51. | |
| AG-024104 | AG-024104 is a broad spectrum cyclin-dependent kinase inhibitor with potential anticancer activity. Synonyms: AG 024104; AG024104. Grades: >98%. CAS No. 750575-23-6. Molecular formula: C24H28F2N6O4S2. Mole weight: 566.64. | |
| AG-024322 | AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. Synonyms: AG-24322; AG 24322; AG24322. Grades: 98%. CAS No. 837364-57-5. Molecular formula: C23H20F2N6. Mole weight: 418.44. | |
| AG-041R | AG-041R is a potent gastrin/CCK2 receptor antagonist that exhibits selective binding for CCK2 compared to CCK1. Synonyms: 1H-Indole-3-acetamide, 1-(2,2-diethoxyethyl)-2,3-dihydro-N-(4-methylphenyl)-3-[[[(4-methylphenyl)amino]carbonyl]amino]-2-oxo-, (+)-; (+)-1-(2,2-Diethoxyethyl)-2,3-dihydro-N-(4-methylphenyl)-3-[[[(4-methylphenyl)amino]carbonyl]amino]-2-oxo-1H-indole-3-acetamide; (+)-AG 041R; AG 041R; (R)-2-(1-(2,2-diethoxyethyl)-2-oxo-3-(3-(p-tolyl)ureido)indolin-3-yl)-N-(p-tolyl)acetamide. Grades: ≥98%. CAS No. 159883-95-1. Molecular formula: C31H36N4O5. Mole weight: 544.64. | |
| AG 045572 | AG 045572, a nonpeptidic GnRH antagonist, could probably be used in the treatment for sex hormone-dependent diseases and infertility. Synonyms: AG 045572; AG045572; AG-045572; 5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxamide. Grades: ≥97% by HPLC. CAS No. 263847-55-8. Molecular formula: C30H37NO5. Mole weight: 491.62. | |
| AG-1024 | AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Synonyms: AG1024; AG-1024; AG 1024. Tyrphostin. Grades: >98%. CAS No. 65678-07-1. Molecular formula: C21H27N7O. Mole weight: 393.23. | |
| AG-120 | AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Synonyms: (2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide; AG-120 (racemic); AG120; AG 120; AG-120; RG-120 (racemic); RG-120, RG 120; Ivosidenib (racemic). Grades: 98%. CAS No. 1448346-63-1. Molecular formula: C28H22ClF3N6O3. Mole weight: 582.97. | |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Synonyms: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. Grades: 95%. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. | |
Our database is helping our users find suppliers everyday.
