BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| A 419259 trihydrochloride | Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo. Synonyms: A419259 trihydrochloride; A-419259 trihydrochloride; RK 20449 trihydrochloride; RK20449 trihydrochloride; RK-20449 trihydrochloride. Grades: >98%. CAS No. 1435934-25-0. Molecular formula: C29H37Cl3N6O. Mole weight: 592.0. |  |
| A 425619 | A 425619 is a potent and selective TRPV1 antagonist (IC50 = 3-9 nM) that inhibits TRPV1 activation by anandamide and N-arachidonoyl-dopamine. A 425619 exhibits an inhibitory effect against inflammatory, postoperative and osteoarthritic in vivo pain models. Uses: Analgesic. Synonyms: A-425619; A 425619; A425619; N-5-Isoquinolinyl-N'-[[(4-(trifluoromethyl)phenyl]methyl]urea. Grades: ≥98% by HPLC. CAS No. 581809-67-8. Molecular formula: C18H14F3N3O. Mole weight: 345.32. | |
| A 437203 | A 437203 is a selective dopamine (DA) D3 receptor antagonist suited to evaluate the physiological role(s) of D3 receptors. A 437203 shows an approximately 100-fold higher in vitro affinity for dopamine D3 versus D2 receptors. Synonyms: 2-[3-[4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]propylsulfanyl]-1H-pyrimidin-6-one; 2-(3-(4-(2-tert-butyl-6-trifluoromethylpyrimidin-4-yl)piperazin-1-yl)propylsulfanyl)-3H-pyrimidin-4-one fumarate; A 437203; A-437203; A437203; 1160247-85-7; 220519-07-3 (anhydrous); 220519-06-2 (anhydrous free base). Grades: >98%. CAS No. 220519-06-2. Molecular formula: C20H27F3N6OS. Mole weight: 456.53. | |
| A-438079 HCl | A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. Synonyms: A-438079 HCl; A 438079 HCl; A438079 HCl. Grades: 98%. CAS No. 899431-18-6. Molecular formula: C13H10Cl3N5. Mole weight: 342.61. | |
| A-485 | A-485 is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM). Synonyms: (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide. Grades: ≥98%. CAS No. 1889279-16-6. Molecular formula: C25H24F4N4O5. Mole weight: 536.48. | |
| A 582941 | A 582941 is a selective α7 nAChR partial agonist which is effetive for both rat and human α7 receptors (Ki = 10.8 and 16.7 nM respectively). Synonyms: A-582941; A 582941; A582941; Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole; (3aR,6aS)-2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole. Grades: ≥98% by HPLC. CAS No. 848591-90-2. Molecular formula: C17H20N4. Mole weight: 280.37. | |
| A 582941 HCl | A 582941 is a selective α7 nAChR partial agonist which is effetive for both rat and human α7 receptors (Ki = 10.8 and 16.7 nM respectively). Synonyms: A-582941 HCl; A582941 HCl. Molecular formula: C17H21ClN4. Mole weight: 316.83. | |
| A-674563 dihydrochloride | A-674563, an Akt1 inhibitor with a Ki of 11 nM, is moderately potent against PKA and >30-fold selective for Akt1 over PKC. Synonyms: A-674563 2HCl; Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, hydrochloride (1:2), (αS)-; (α S) -α - [ [ [5- (3-Methyl-1H-indazol-5-yl) -3-pyridinyl] oxy] methyl] benzeneethanamine dihydrochloride; (S)-1-((5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine hydrochloride; A 674563 dihydrochloride; A674563 dihydrochloride. Grades: ≥95%. CAS No. 2759293-92-8. Molecular formula: C22H22N4O.2HCl. Mole weight: 431.36. | |
| A-71623 | A-71623 is a tetrapeptide and acts as a potent CCK1 agonist (IC50 = 3.7 nM) displaying 1200-fold selectivity over the CCK2 receptor. A-71623 is used to suppress appetite and reduce food intake following central or peripheral administration. Synonyms: A 71623; A-71623; A71623; N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide. CAS No. 130408-77-4. Molecular formula: C44H56N8O9. Mole weight: 840.97. | |
| A-740003 | A-740003 is potent, selective and competitive P2X7 receptor antagonist. Its IC50 values are 18 and 40 nM for rat and human receptors respectively measured by agonist-stimulated changes in intracellular calcium concentrations. It displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μM. It reduces nociception in animal models of persistent neuropathic and inflammatory pain. It showed weak or no activity (IC(50) > 10 muM) at other P2 receptors and an array of other neurotransmitter and peptide receptors, ion channels, reuptake sites, and enzymes. It potently blocked agonist-evoked IL-1beta release (IC(50) = 156 nM) and pore formation (IC(50) = 92 nM) in differentiated human THP-1 cells. It produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Uses: A-740003 produces significant antinociception in animal models of neuropathic and inflammatory pain in vivo. Synonyms: A-740003; A 740003; A740003; N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide. Grades: >98 %. CAS No. 861393-28-4. Molecular formula: C26H30N6O3. Mole weight: 474.55. | |
| A-769662 | A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity. Synonyms: 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile. Grades: ≥95%. CAS No. 844499-71-4. Molecular formula: C20H12N2O3S. Mole weight: 360.4. | |
| A-770041 | A-770041 is an selective and orally bioavailable pyrazolo[3,4-d]pyrimidine exhibiting selectivity for Lck compared with previously reported compounds. It is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. It is currently in the preclinical developlent stage and no clinical data are available. Synonyms: A-770041; A 770041; A770041. Grades: >98%. CAS No. 869748-10-7. Molecular formula: C34H39N9O3. Mole weight: 621.73. | |
| A 779 TFA | A 779 TFA is a potent angiotensin (1-7) receptor antagonist. Synonyms: H-Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH.TFA; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-D-alanine trifluoroacetic acid; A-779 trifluoroacetate salt; (D-Ala7)-Angiotensin I/II (1-7) Trifluoroacetate; 5-L-Isoleucine-7-D-alanine-1-7-angiotensin II trifluoroacetate; A 779 TFA. Grades: ≥95%. Molecular formula: C41H61F3N12O13. Mole weight: 987.01. | |
| A 784168 | A 784168 is a potent and selective TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin) exhibiting no activity against a range of receptors such as TRPA1, GABA, opioid, and purinergic receptors. Synonyms: A 784168; A784168; A-784168; 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide; 1-[3-(trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide. Grades: ≥99% by HPLC. CAS No. 824982-41-4. Molecular formula: C19H15F6N3O3S. Mole weight: 479.4. | |
| A-803467 | A-803467 is a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50=140 nM). Synonyms: A-803467; A 803467; A803467. Grades: >98%. CAS No. 944261-79-4. Molecular formula: C19H16ClNO4. Mole weight: 357.79. | |
| A 80426 mesylate | A 80426 mesylate is a potent α2-adrenoceptor antagonist and a selective 5-HT uptake inhibitor (Ki = 2.01 and 3.77 nM, respectively). It displays low affinity for a panel of structurally homologous GPCRs. Synonyms: A-80426 mesylate; A 80426 mesylate; A80426 mesylate; N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-6-benzofuranethanamine mesylate. Grades: ≥98% by HPLC. CAS No. 152148-64-6. Molecular formula: C23H27NO2.CH3SO3H. Mole weight: 445.57. | |
| A 839977 | A-839977 is a novel and selective P2X7 antagonist. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors with IC50 values 20, 42 and 150 nM respectively. It also potently blocked agonist-evoked YO-PRO uptake and IL-1beta release from differentiated human THP-1 cells. It also produced robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice. It has been exhibited to reduce CFA-induced thermal hyperalgesia in a dose-dependent fashion with the ED50 value of 100μmol/kg. Synonyms: 1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine. Grades: >98 %. CAS No. 870061-27-1. Molecular formula: C19H14Cl2N6O. Mole weight: 413.26. | |
| A 841720 | A 841720 is a potent non-competitive mGlu1 receptor antagonist (IC50 = 10 nM) exhibiting 34-fold selectivity over mGluR5 and inactive to other mGluR receptors, neurotransmitter receptors, ion channels, and transporters. It inhibits complete Freund's adjuvant-induced inflammatory pain (ED50 = 23 μmol/kg) and decreases mechanical allodynia (ED50 = 28 μmol/kg) in mouse models. Synonyms: A-841720; A 841720; A841720; 3-(azepan-1-yl)-9-(dimethylamino)pyrido[1,2]thieno[3,4-d]pyrimidin-4-one. Grades: 99%. CAS No. 869802-58-4. Molecular formula: C17H21N5OS. Mole weight: 343.45. | |
| A 844606 | A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 = 1.4 and 2.2 μM at human and rat receptors, respectively). It has no measurable effect on α4β2 nAChRs. Synonyms: A 844606; A844606; A-844606; 2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one. Grades: ≥99% by HPLC. CAS No. 861119-08-6. Molecular formula: C20H20N2O2. Mole weight: 320.38. | |
| A 85380 dihydrochloride | A 85380 dihydrochloride is a selective α4β2 nACh receptor agonist (Ki = 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors, respectively). Synonyms: A 85380 dihydrochloride; A85380 dihydrochloride; A-85380 dihydrochloride; 3-[(2S)-2-Azetidinylmethoxy]-pyridine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 174740-86-4. Molecular formula: C9H12N2O.2HCl. Mole weight: 237.13. | |
| A-867744 | A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. Synonyms: A-867744; A 867744; A867744. Grades: >98%. CAS No. 1000279-69-5. Molecular formula: C20H19ClN2O3S. Mole weight: 402.89. | |
| A 887826 | A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). A 887826 is effective on reducing tactile allodynia in neuropathic rat models. Synonyms: A 887826; A887826; A-887826; 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide. Grades: ≥97% by HPLC. CAS No. 1266212-81-0. Molecular formula: C26H29ClN4O3. Mole weight: 480.99. | |
| A-893 | A-893 is an inhibitor of SMYD2, which is a lysine methyltransferase. The co-crystal structure reveals the origin of enhanced potency, and effective inhibition of p53K370 methylation in a lung carcinoma (A549) cell line. Synonyms: A893; A 893; (R)-N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-hydroxy-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide; Propanamide, N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[(2R)-2-(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-8-yl)-2-hydroxyethyl]amino]ethyl]-; N-Cyclohexyl-N3-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[(2R)-2-hydroxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-β-alaninamide. Grades: ≥98%. CAS No. 1868232-32-9. Molecular formula: C29H38Cl2N4O4. Mole weight: 577.54. | |
| A922500 | A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets. Synonyms: A922500; A 922500; A-922500. Grades: >98%. CAS No. 959122-11-3. Molecular formula: C26H24N2O4. Mole weight: 428.48. | |
| A939572 | A939572 is a effective and highly selective cell-permeable inhibitor of SCD1(stearoyl-CoA desaturase 1) which could be mediated by hormonal and dietary actions. It is under early phase clinical trials for its potential effect in obesity and diabetes. IC50. Uses: A939572 is a effective and highly selective cell-permeable inhibitor of scd1(stearoyl-coa desaturase 1) which could be mediated by hormonal and dietary actions. Synonyms: A939572; A-939572; A 939572. SCD inhibitor; 4-(2-chlorophenoxy)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide; 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide; CHEMBL469169; 4-(2-CHLOROPHENOXY)-N-[3-[(METHYLAMINO)CARBONYL]PHENYL]-1-PIPERIDINECARBOXAM. Grades: 95%. CAS No. 1032229-33-6. Molecular formula: C20H22ClN3O3. Mole weight: 387.86. | |
| A 943931 | A 943931 is a potent and selective histamine H4 receptor antagonist. Synonyms: A-943931; A 943931; A943931; D0P8DW; 4-[(3R)-3-aminopyrrolidin-1-yl]-6,7-dihydro-5H-benzo[1,2]cyclohepta[3,4-b]pyrimidin-2-amine. Grades: 99%. CAS No. 1027330-97-7. Molecular formula: C17H21N5. Mole weight: 295.38. | |
| A 943931 dihydrochloride | A 943931 dihydrochloride is a potent and selective histamine H4 receptor antagonist (pKi = 7.15 and 8.12 at human and rat receptors, respectively). A 943931 blocks inflammation in a peritonitis mouse model and displays efficacy in inflammatory pain and neuropathic pain models. Synonyms: A 943931 dihydrochloride; A943931 dihydrochloride; A-943931 dihydrochloride; 4-((3R)-3-amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine. Grades: ≥98% by HPLC. CAS No. 1227675-50-4. Molecular formula: C17H21N5.2HCl. Mole weight: 368.31. | |
| A-966492 | A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. Synonyms: A966492; A 966492. Grades: >98%. CAS No. 934162-61-5. Molecular formula: C18H17FN4O. Mole weight: 324.35. | |
| A - 971432 | This active molecular is a selective S1P5 (Sphingosine-1-Phosphate Receptor 5) agonist originated by AbbVie for the treatment of neurodegenerative disorders. A 971432 is highly selective for S1P5 with IC50 value of 6 nM for S1P5, 362 nM for S1P1 and >10 μM for S1P3. A 971432 improves blood-brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonists have been reported as an innovative mechanism for the treatment of neurodegenerative disorders including Alzheimer's disease and lysosomal storage disorders such as Niemann-Pick disease. Uses: Neurodegenerative disorder;lysosomal storage disorders. Synonyms: A971432; A 971432; 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid. Grades: 95%. CAS No. 1240308-45-5. Molecular formula: C18H17Cl2NO3. Mole weight: 366.24. | |
| A 987306 | A 987306 is a potent histamine H4 receptor antagonist (pKi = 8.24 and 8.47 in human and rat H4 receptors, respectively) with 162-, 620-, and > 1600-fold selectivity over human H3, H1 and H2 receptors. It suppresses zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED50 = 42 μmol/kg, ip). Synonyms: A 987306; A987306; A-987306; (±)-(7aR,11aR)-5,6,7a,8,9,10,11,11a-Octahydro-4-(1-piperazinyl)-benzofuran[2,3-h]quinazolin-2-amine. Grades: ≥98% by HPLC. CAS No. 1082954-71-9. Molecular formula: C18H25N5O. Mole weight: 327.42. | |
| AA26-9 | AA26-9, synthesized based on a piperazine scaffold, is a potent and broad spectrum serine hydrolase inhibitor. Synonyms: AA 26-9; AA-26-9; AA26-9; AA 269; AA-269; AA269; pyrrolidin-1-yl(triazol-1-yl)methanone; Pyrrolidin-1-yl(1H-1,2,3-triazol-1-yl)methanone. CAS No. 1312782-34-5. Molecular formula: C7H10N4O. Mole weight: 166.18. | |
| AA 29504 | AA 29504 is a positive allosteric modulator of GABAA receptors with anxiolytic activity. It modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes. AA 29504 is potentially used for the treatment of schizophrenia. Uses: Potential treatment of schizophrenia. Synonyms: AA 29504; AA29504; AA-29504; N1-Ethoxycarbonyl-N4-[(2,4,6-trimethylpheny)lmethyl]-1,2,4-triaminobenzene; ethyl N-[2-amino-4-[ (2, 4, 6-trimethylphenyl) methylamino]phenyl]carbamate. Grades: ≥98% by HPLC. CAS No. 945828-50-2. Molecular formula: C19H25N3O2. Mole weight: 327.42. | |
| a,a-Difluorophenylacetic acid ethyl ester | Synonyms: ethyl difluoro(phenyl)acetate; ethyl alpha,alpha-difluorophenylacetate. CAS No. 2248-46-6. Molecular formula: C10H10F2O2. Mole weight: 200.183. | |
| AADvac-1 | AADvac-1 is an active vaccine designed to raise antibodies against pathological tau protein (the primary constituent of neurofibrillary pathology in AD). These antibodies are expected to prevent tau protein from aggregating, to facilitate the removal of tau protein aggregates and prevent the spreading of pathology, slowing or halting the progress of the disease. Synonyms: AADvac-1; Alzheimer's disease vaccine - Axon Neuroscience; Axon peptide 108 conjugated to KLH; Axon peptide 108 coupled to KLH. CAS No. 2307465-24-1. | |
| AAE871 | AAE871 is a type I FLT3 inhibitor. Synonyms: AAE-871; AAE 871; 9H-Purine-2,6-diamine, N2-(trans-4-aminocyclohexyl)-9-ethyl-N6-[4-(1-piperidinylsulfonyl)phenyl]-. Grades: >98%. CAS No. 289479-07-8. Molecular formula: C24H34N8O2S. Mole weight: 498.64. | |
| Aaf-Arg-OH HCl | Aaf-Arg-OH HCl, a substrate of carboxypeptidase B-type enzymes, has been used to determine the activation of TAFI (thrombin activatable fibrinolysis inhibitor, carboxypeptidase U) by thrombin and thrombin-thrombomodulin. Synonyms: N-(4-Methoxyphenylazoformyl)-Arg-OH HCl; N2-{[(4-Methoxyphenyl)diazenyl]carbonyl}-L-arginine hydrochloride (1:1); L-Arginine, N2-[[2-(4-methoxyphenyl)diazenyl]carbonyl]-, hydrochloride (1:1). Grades: ≥95% by HPLC. CAS No. 442158-31-8. Molecular formula: C14H20N6O4.HCl. Mole weight: 372.81. | |
| AAL-993 | AAL-993 is a VEGFR tyrosine kinase inhibitor that possesses dual inhibition of VEGFR signaling and HIF-1α expression through ERK inhibition without affecting Akt phosphorylation. Synonyms: AAL 993; AAL993; 2-((4-pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide. Grades: >98%. CAS No. 269390-77-4. Molecular formula: C20H16F3N3O. Mole weight: 371.36. | |
| AAQ chloride | AAQ chloride is a photoswitchable Kv channel blocker (IC50 = 2 and 64 μM at 500 nm and 380 nm, respectively) that switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. AAQ chloride also stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm. Synonyms: N, N, N-Triethyl-2-oxo-2- [ [4- [2- [4- [ (1-oxo-2-propen-1-yl) amino] phenyl] diazenyl] phenylamino] ethanaminium chloride. Grades: ≥98% by HPLC. Molecular formula: C23H30ClN5O2. Mole weight: 443.97. | |
| AB-423 | AB-423 is an inhibitor of HBV capsid assembly, and potent inhibits HBV replication with EC50/EC90 of 0.08-0.27 μM/0.33-1.32 μM in cells. Synonyms: 5-[[(2R)-butan-2-yl]sulfamoyl]-N-(3,4-difluorophenyl)-2-fluorobenzamide. Grades: ≥98%. CAS No. 1572510-80-5. Molecular formula: C17H17F3N2O3S. Mole weight: 386.39. | |
| Abaloparatide acetate | Abaloparatide acetate, an effective and selective activator of the PTHR1 signaling pathway, is an analog of parathyroid hormone-related protein (PTHrP) used for the treatment of osteoporosis. Synonyms: H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2.CH3CO2H; L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-leucyl-alpha-methyl-alanyl-L-lysyl-L-leucyl-L-histidyl-L-threonyl-L-alaninamide acetic acid. Grades: ≥95%. Molecular formula: C176H304N56O51. Mole weight: 4020.71. | |
| Abaloparatide TFA | Abaloparatide TFA is an analog of parathyroid hormone-related protein (PTHrP) used for the treatment of osteoporosis. Synonyms: H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2.TFA; L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-leucyl-alpha-methyl-alanyl-L-lysyl-L-leucyl-L-histidyl-L-threonyl-L-alaninamide trifluoroacetic acid; BIM 44058 trifluoroacetate; Eladynos trifluoroacetate. Grades: ≥95%. Molecular formula: C176H301N56F3O51. Mole weight: 4074.61. | |
| Abametapir | Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. Uses: 5,5'-dimethyl-2,2'-bipyridine is used in preparation of iron bipyridine acetoacetate complexes. Synonyms: 5,5'-Dimethyl-2,2'-bipyridine; 6,6'-Bi-3-picoline; 5,5'-Dimethyl-2,2'-bipyridyl. Grades: 98 %. CAS No. 1762-34-1. Molecular formula: C12H12N2. Mole weight: 184.24. | |
| ABC-1183 | ABC-1183 is an inhibitor of glycogen synthase kinase 3 (GSK-3) alpha, glycogen synthase kinase 3 (GSK-3) beta and cyclin dependent kinase 9 (CDK-9). It can induce cell apoptosis and various signaling pathways. ABC-1183 shows toxicity to many cell lines in humans and mice. Synonyms: ABC1183; ABC 1183; NSC797769; NSC-797769. Grades: > 99% by HPLC. CAS No. 1042735-18-1. Molecular formula: C18H14N4OS. Mole weight: 334.39. | |
| ABC294735 | ABC294735 is a dual SK1/SK2 inhibitor with potential anticancer activity. Synonyms: ABC-294735; ABC 294735. Grades: >98%. CAS No. 917236-13-6. Molecular formula: C24H26ClNO3. Mole weight: 411.92. | |
| ABD459 | ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). Synonyms: [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl](4-methoxyphenyl)-methanone. Grades: ≥95%. CAS No. 1047670-51-8. Molecular formula: C24H17BrCl2N2O2. Mole weight: 516.2. | |
| ABET | Arecaidine But-2-ynyl Ester Tosylate (ABET) is a potent and selective agonist of M2 recceptors in the atrium versus those in the ileum. Synonyms: Arecaidine but-2-ynyl ester tosylate; N-Methyl-1'2'5'6-tetrahydropyridine-3-carboxylic acid but-2-ynyl ester tosylate. CAS No. 119630-77-2. Molecular formula: C18H23NO5S. Mole weight: 365.444. | |
| ABI-H-0731 | | |
| Abituzumab | Abituzumab is a humanized anti-integrin αV monoclonal antibody developed for the treatment of prostate cancer metastatic. Abituzumab binds to αVβ3 and inhibits endothelial cell-cell interactions, endothelial cell-matrix interactions, and integrin-mediated tumor angiogenesis and metastasis in αVβ3-expressing tumor cells. Synonyms: EMD 525797; DI17E6. CAS No. 1105038-73-0. | |
| Abl Cytosolic Substrate acetate | Abl Cytosolic Substrate acetate is a substrate for Abelson tyrosine kinase (Abl). Synonyms: Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys acetate salt; L-α-Glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-L-Lysine acetate salt. Grades: ≥95%. CAS No. 2918768-10-0. Molecular formula: C64H101N15O16.C2H4O2. Mole weight: 1396.63. | |
| A(Boc) Acetic acid | A nucleobase for PNA synthesis. Synonyms: 2-(6-((Tert-Butoxycarbonyl)amino)-9H-purin-9-yl)acetic acid; 6-(tert-Butoxycarbonylamino)-9H-purine-9-acetic acid; (N6-Boc-N9-adeninyl)acetic acid; N6-Boc-adenosin-9-yl acetic acid. Grades: 98%. CAS No. 186046-99-1. Molecular formula: C12H15N5O4. Mole weight: 293.28. | |
| ABP 688 | ABP 688 is a high affinity human mGlu5 receptor antagonist (Ki = 1.7 nM) that inhibits the release of glutamate-induced calcium from L(tk-) cells expressing human mGlu5 receptors (IC50 = 2.3 nM). Synonyms: ABP688; ABP-688; ABP 688; 3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime; N-methoxy-3-[2-(6-methylpyridin-2-yl)ethynyl]cyclohex-2-en-1-imine. Grades: ≥98% by HPLC. CAS No. 924298-51-1. Molecular formula: C15H16N2O. Mole weight: 240.3. | |
| Abrilumab | Abrilumab is a human monoclonal antibody against α4β7, which is a validated target in inflammatory bowel disease. CAS No. 1342290-43-0. | |
| ABT-046 | ABT-046 is a potent, selective, and orally bioavailable Diacylglycerol acyltransferase 1 (DGAT-1 ) inhibitor (IC50=8 nM). Synonyms: ABT-046; ABT 046; ABT046. Grades: >98%. CAS No. 1031336-60-3. Molecular formula: C20H22N4O2. Mole weight: 350.41. | |
| ABT-080 | ABT-080 is a leukotriene synthesis inhibitor potentially for the treatment of asthma. Synonyms: Benzenebutanoic acid, γ-methyl-4-(2-quinolinylmethoxy)-γ-[4-(2-quinolinylmethoxy)phenyl]-, sodium salt (1:1); Benzenebutanoic acid, γ-methyl-4-(2-quinolinylmethoxy)-γ-[4-(2-quinolinylmethoxy)phenyl]-, monosodium salt; 4,4-bis(4-(2-quinolylmethoxy)phenyl)pentanoic acid sodium salt; ABT 080; ABT080; VML 530; VML530; VML-530. Grades: ≥95%. CAS No. 189498-57-5. Molecular formula: C37H31N2NaO4. Mole weight: 590.64. | |
| ABT-100 | ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. Synonyms: ABT 100; ABT100; A-367074; A 367074; A367074. Grades: >98%. CAS No. 450839-40-4. Molecular formula: C27H19F3N4O3. Mole weight: 504.47. | |
| ABT 239 tartrate | ABT 239 tartrate is a potent and selective histamine H3 receptor antagonist or inverse agonist. Synonyms: ABT 239 tartrate; ABT239 tartrate; ABT-239 tartrate; (2R,3R)-2,3-dihydroxybutanedioic acid; 4-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]benzonitrile. Grades: 98%. CAS No. 460748-71-4. Molecular formula: C22H22N2O.C4H6O6. Mole weight: 480.51. | |
| ABT-255 Hcl | ABT-255, a novel 2-pyridone antibacterial agent, is an analog of ABT-719 with improvements in the therapeutic margin against common gram-positive and -negative bacterial infections. ABT-255 demonstrated in vitro potency and in vivo efficacy against both drug-susceptible and drug-resistant M. tuberculosis strains. Synonyms: ABT-255 Hcl; ABT 255 Hcl; ABT255 Hcl; 8-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxoquinolizine-3-carboxylic acid;hydrochloride; UNII-YA04O24J4T; 186293-38-9 (ABT-255 free base)SCHEMBL8471955; YA04O24J4T; 181141-52-6; 4H-Quinolizine-3-carboxylic acid, 1-cyclopropyl-7-fluoro-9-methyl-8-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-, monohydrochloride; 4H-Quinolizine-3-carboxylic acid, 1-cyclopropyl-7-fluoro-9-methyl-8-(octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-, monohydrochloride, (4as-cis)-. Grades: >98%. CAS No. 181141-52-6. Molecular formula: C21H25ClFN3O3. Mole weight: 421.89. | |
| ABT279 | ABT279 is a bio-active chemical coumpound. It is used for the treatment of type 2 diabetes. It was developed by Abbvie and was in clinical phase 1 trial, but now it is terminated. Uses: Abt279 is used for the treatment of type 2 diabetes. Synonyms: ABT-279; ABT 279; 4-Pyridinecarboxylic acid, 2-(4-((2-((2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-. Grades: 98%. CAS No. 676559-83-4. Molecular formula: C21H25N5O3. Mole weight: 395.46. | |
| ABT-491 | ABT-491, an imidazopyridine derivative, has been found to be a PAF receptor antagonist that was once studied against allergic rhinitis. Synonyms: ABT-491 free base; ABT-491; ABT491; ABT 491; UNII-AYB44L739V; CHEMBL369225; ABT 491; 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide. Grades: 98%. CAS No. 170499-15-7. Molecular formula: C28H22FN5O2. Mole weight: 479.52. | |
| ABT-491 Hydrochloride | ABT-491 Hydrochloride is a potent, selective and orally active platelet-activating factor receptor (PAF-R) antagonist (Ki = 0.6 nM in human platelets). Synonyms: 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide;hydrochloride; ABT 491 hydrochloride; ABT 491; ABT-491; ABT491. Grades: >98%. CAS No. 189689-94-9. Molecular formula: C28H23ClFN5O2. Mole weight: 515.97. | |
| ABT-518 | ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis. Synonyms: ABT 518; ABT518; N- ( (S) -1- ( (S) -2, 2-Dimethyl-1, 3-dioxolan-4-yl) -2- ( (4- (4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) -N-hydroxyformamide. CAS No. 286845-00-9. Molecular formula: C21H22F3NO8S. Mole weight: 505.46. | |
| ABT670 | ABT670 is a drug which acts as a potent, superior orally bioavailable dopamine agonist selective for the D4 subtype. It was used as a possible treatment for erectile dysfunction. Uses: Abt670 was used as a possible treatment for erectile dysfunction. Synonyms: ABT-670; ABT 670; Benzamide, 3-methyl-N-[[4-(1-oxido-2-pyridinyl)-1-piperidinyl]methyl]-;3-Methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridine)-1'-ylmethyl)benzamide. Grades: 98%. CAS No. 630119-43-6. Molecular formula: C19H23N3O2. Mole weight: 325.41. | |
| ABT724 | ABT-724 is a dopamine D4 agonist originated by Abbott Laboratories with EC50 value of 12.4 nM. In Dec 2007, Phase-II for Erectile dysfunction was discontinued in USA. Now ABT-724 continues to be used in scientific research into the function of the D4 receptor. Uses: Erectile dysfunction. Synonyms: ABT724; ABT 724; ABT-724; 2-((4-Pyridin-2-ylpiperazine-1-yl)methyl)-1H-benzimidazole;587870-77-7(ABT 724 trihydrochloride). Grades: 98%. CAS No. 70006-24-5. Molecular formula: C17H19N5. Mole weight: 293.37. | |
| ABT-770 | ABT-770 is a selective and orally bioavailable MMP inhibitor. Synonyms: ABT-770; ABT 770; ABT770; UNII-I8NWP25THF; N-[ (2S) -1- (4, 4-dimethyl-2, 5-dioxoimidazolidin-1-yl) -3-[4-[4- (trifluoromethoxy) phenyl]phenoxy]propan-2-yl]-N-hydroxyformamide; UNII-I8NWP25THF; CHEMBL40143. Grades: >98%. CAS No. 220614-50-6. Molecular formula: C22H22F3N3O6. Mole weight: 481.42. | |
| ABT-866 | ABT-866 is a novel alpha-adrenoceptor agent that demonstrates intrinsic activity at the α1A-adrenoceptor subtype present in the rabbit urethra (pD2=6.22, with 80% of the phenylephrine response). Synonyms: N-[3-(1H-imidazol-5-ylmethyl)phenyl]ethanesulfonamide; ABT-866; ABT 866; ABT866; A 286666; A286666; A-286666. Grades: >98%. CAS No. 258526-74-8. Molecular formula: C12H15N3O2S. Mole weight: 265.33. | |
| ABT 925 Fumerate | A 437203 is a selective dopamine (DA) D3 receptor antagonist suited to evaluate the physiological role(s) of D3 receptors. A 437203 shows an approximately 100-fold higher in vitro affinity for dopamine D3 versus D2 receptors. Synonyms: (E)-but-2-enedioic acid;2-[3-[4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]propylsulfanyl]-1H-pyrimidin-6-one; UNII-DMH23OL273; 220519-07-3 (anhydrous); 220519-06-2 (anhydrous free base); ABT-925 anhydrous; ABT 925 Fumerate; ABT925 Fumerate; ABT-925 Fumerate. Grades: >98%. CAS No. 220519-07-3. Molecular formula: C24H31F3N6O5S. Mole weight: 572.604. | |
| ABTS Chromophore Diammonium Salt | ABTS Chromophore Diammonium Salt can inhibit catalase, a mammalian antioxidant enzyme which degrades hydrogen peroxide into water and oxygen species. Synonyms: 2,2'-(1,2-Hydrazinediylidene)bis[3-ethyl-2,3-dihydro-6-benzothiazolesulfonic Acid Ammonium Salt (1:2); 2,2'-Azinobis[3-ethyl-2,3-dihydro-6-benzothiazolesulfonic Acid Diammonium Salt; 3-Ethyl-2-oxo-6-Benzothiazolinesulfonic Acid Azine Diammonium Salt; 2,2'-Azino-bis-(3-ethyl-benzthiazoline-6-sulfonate) Diammonium Salt; 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt; ABTS Diammonium Salt; Diammonium 2,2'-Azinobis(3-ethyl-6-benzothiazolinesulfonate); Diammonium 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate). Grades: ≥98%. CAS No. 30931-67-0. Molecular formula: C18H24N6O6S4. Mole weight: 548.68. | |
| Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide | Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide is a fluorogenic substrate for neutral metalloendopeptidases. Synonyms: XAGLA. CAS No. 100307-95-7. Molecular formula: C28H37N7O7. Mole weight: 583.63. | |
| Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor/acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Synonyms: JMV2236; L-α-Glutamine, N-(2-aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-[2-[(2,4-dinitrophenyl)amino]ethyl]-; N-(2-Aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-{2-[(2,4-dinitrophenyl)amino]ethyl}-L-α-glutamine. Grades: ≥95%. CAS No. 1007306-20-8. Molecular formula: C42H58N12O16. Mole weight: 986.99. | |
| Abz-FR-K(Dnp)-P-OH acetate | An angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay. Molecular formula: C41H53N11O12. Mole weight: 891.95. | |
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