BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| alpha-Dendrotoxin | alpha-Dendrotoxin is from the venom of the Eastern green mamba, Dendroaspis angusticeps. It selectively blocks voltage-gated activation of the K+ channels in the synaptosomes. Synonyms: α-Dendrotoxin (reduced); α-DTX; Pyr-Pro-Arg-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Asp-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Arg-Phe-Asp-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Gly-OH (Disulfide bridge: Cys7-Cys57, Cys16-Cys40, Cys32-Cys53); Toxin C13S2C3 (Dendroaspis angusticeps reduced). Grades: ≥98% by HPLC. CAS No. 74504-53-3. Molecular formula: C305H472N98O84S6. Mole weight: 7048.11. |  |
| alpha-Endorphin acetate | alpha-Endorphin acetate is a related peptide of the pro-opiomelanocortin family with characteristic biological activities. α-Endorphin is an endogenous neuropeptide that binds to opioid receptors. Synonyms: Lipotropin 61-76 acetate; α-Endorphin acetate; 1-16-Human β-endorphin acetate; Human β-endorphin-(1-16) acetate; Porcine α-endorphin acetate; H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-OH.CH3CO2H; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-methionyl-L-threonyl-L-seryl-L-alpha-glutamyl-L-lysyl-L-seryl-L-glutaminyl-L-threonyl-L-prolyl-L-leucyl-L-valyl-L-threonine acetate. Grades: ≥95%. Molecular formula: C79H124N18O28S. Mole weight: 1806.00. | |
| alpha-ISOMETHYL IONONE BRI | Synonyms: 3-Buten-2-one, 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, alpha-ISOMETHYL IONONE BRI FCC, gamma-Methyl ionone, Isoraldeine. Grades: 95.0%. CAS No. 127-51-5. Molecular formula: C14H22O. Mole weight: 206.33. | |
| alpha-L-Rhamnose | Alpha-L-rhamnopyranose is found in Citrus reticulata. Synonyms: Alpha-l-rhamnopyranose; 6-deoxy-alpha-L-mannopyranose. CAS No. 6014-42-2. Molecular formula: C6H12O5. Mole weight: 164.16. | |
| α-Methyl-γ-hydroxy-1,N2-propano-2'-deoxyguanosine (Mixture of Diastereomers) | A genotoxic cyclic adduct of 2'-deoxyguanosine with crotonaldehyde. Uses: A genotoxi. Synonyms: 3-(2-Deoxy-β-D-erythro-pentofuranosyl)-4,6,7,8-tetrahydro-8-hydroxy-6-methylpyrimido[1,2-a]purin-10(3H)-one; α-Me-γ-OH-PdG; Cr-PdG. Grades: 98%. CAS No. 132014-87-0. Molecular formula: C14H19N5O5. Mole weight: 337.33. | |
| alpha-Spinasterol methylthiomethyl ether | alpha-Spinasterol methylthiomethyl ether is a natural compound, finding profound utility within the investigation of diverse maladies such as cancer, inflammation and cardiovascular disorders. | |
| α-Thymidine | As an epimer of Thymidine, α-Thymidine is also useful in the synthesis of oligonucleotides containing α-Thymidine. Synonyms: Alpha-thymidine; 1-(2-Deoxy-α-D-erythro-pentofuranosyl)thymine;2'-Deoxy-α-D-ribofuranosylthymine; 1-(2-Deoxy-α-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione. CAS No. 4449-43-8. Molecular formula: C10H14N2O5. Mole weight: 242.23. | |
| Alphazurine FG | Alphazurine FG is a colorant and opacifier. Synonyms: diammonium 2-((4-(ethyl(4-sulfonatobenzyl)amino)phenyl)((4-(ethyl(4-sulfonatobenzyl)iminio)cyclohexa-2,5-dien-1-ylidene)methyl)benzenesulfonate; Benzenemethanaminium, N-ethyl-N-[(1Z,4Z)-4-[[4-[ethyl[(4-sulfophenyl)methyl]amino]phenyl](2-sulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-4-sulfo-, inner salt, ammonium salt; Ammonium, ethyl(4-(p-(ethyl(m-sulfobenzyl)amino)-α-(o-sulfophenyl)benzylidene)-2,5-cyclohexadien-1-ylidene)(m-sulfobenzyl)-, hydroxide, inner salt, diammonium salt. Grades: 99%. CAS No. 6371-85-3. Molecular formula: C37H42N4O9S3. Mole weight: 782.95. | |
| Alprenolol hydrochloride | Alprenolol hydrochloride is the hydrochloride salt of alprenolol, which is a non-selective 5-HT1A receptor antagonist and beta blocker. It is used in the treatment of angina pectoris. It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically. Uses: Adrenergic beta-antagonists. Synonyms: 1-[(1-Methylethyl)amino]-3-[2-(2-propen-1-yl)phenoxy]-2-propanol Hydrochloride; 1-(o-Allylphenoxy)-3-(isopropylamino)-2-Propanol Hydrochloride; 1-[(1-Methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-2-propanol Hydrochloride; (±)-1-(o-Allylphenoxy)-3-isopropylamino-2-propanol Hydrochloride; (±)-Alprenolol Hydrochloride; 1-(2-Allylphenoxy)-2-hydroxy-3-isopropylaminopropane Hydrochloride; Alfeprol; DL-1-(o-Allylphenoxy)-3-isopropylamino-2-propanol Hydrochloride; Dimacor; Gubernal; dl-Alprenolol Chloride. Grades: ≥99% by HPLC. CAS No. 13707-88-5. Molecular formula: C15H24NO2Cl. Mole weight: 285.81. | |
| Alrestatin | Alrestatin is an inhibitor of aldose reductase (IC50 = 148 μM). Uses: Specific inhibitor of aldose reductase. Synonyms: Alrestatine; 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid. Grades: ≥98%. CAS No. 51411-04-2. Molecular formula: C14H9NO4. Mole weight: 255.23. | |
| Alrestatin (sodium) | Alrestatin sodium is a specific inhibitor of aldose reductase (IC50 = 148 μM). Uses: A specific inhibitor of aldose reductase. Synonyms: Sodium;2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetate. Grades: ≥98%. CAS No. 51876-97-2. Molecular formula: C14H8NNaO4. Mole weight: 277.21. | |
| Alrizomadlin | Alrizomadlin is a highly potent and chemically stable E3 ubiquitin-protein ligase Mdm2 (Hdm2) inhibitor. It is used in the treatment and prevention of osteoarthritis. Synonyms: APG-115; AA-115; 4-((3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid; APG115; APG 115; NSC831270. Grades: >98%. CAS No. 1818393-16-6. Molecular formula: C34H38Cl2FN3O4. Mole weight: 642.59. | |
| ALS-8176 (active form) | ALS-8176 (active form), a 4'-substituted cytidine analogue, is a potent, selective RSV polymerase inhibitor. It has an EC50 of 0.15 μM in the RSV replicon assay and an IC50= 0.02 μM due to its corresponding 5'-triphosphate in the RSV polymerase assay. Synonyms: 4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-oneALS-8176 (active form); ALS-8112; ALS8112; ALS 8112. UNII-7795987MKM7795987MKMCHEMBL3417243SCH EMBL15070479CS-5472; HY-12983; CS 5472; HY 12983; CS5472; HY129834'-Chloromethyl-2'-deoxy-2'-fluorocytidineCytidine. Grades: 99.67%. CAS No. 1445379-92-9. Molecular formula: C10H13ClFN3O4. Mole weight: 293.68. | |
| Alsevalimab | Alsevalimab is a human monoclonal antibody that targets B7-H4 with potential antineoplastic and immune checkpoint inhibitory activities. CAS No. 2254029-91-7. | |
| Alstonine | Cas No. 642-18-2. | |
| Altanserin hydrochloride | Altanserin hydrochloride is the hydrochloride salt of altanserin, which is a selective and potent 5-HT2A receptor antagonist with Ki value of 0.13 nM. It is centrally active following systemic administration in vivo. It is also a useful intermediate for organic synthesis. Synonyms: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride. Grades: ≥98% by HPLC. CAS No. 1135280-78-2. Molecular formula: C22H23FN3O2SCl. Mole weight: 447.95. | |
| Altretamine | Altretamine is an anti-neoplastic agent. Uses: An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. antineoplastic. Synonyms: 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine. Grades: > 98 %. CAS No. 645-05-6. Molecular formula: C9H18N6. Mole weight: 210.28. | |
| Altretamine hydrochloride | Altretamine hydrochloride, also called as hexamethylmelamine hydrochloride, is an alkylating agent with apparently less toxicity compared to other cytotoxic drugs used for palliation of patients with recurrent epithelial ovarian cancer. Synonyms: 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine;hydrochloride Altretamine hydrochloride Altretamine (hydrochloride) 2975-00-0 Hexamethylmelamine HCl UNII-30FQ7QG6VM 1,3,5-Triazine-2,4,6-triamine, N,N,N',N',N'',N''-hexamethyl-, monohydroch. CAS No. 2975-00-0. Molecular formula: C9H19ClN6. Mole weight: 246.74. | |
| Alum Adjuvant | Alum Adjuvant is insoluble white colloidal suspension of aluminum hydroxide used to potentiate immune response. Antigen adsorbs on the aluminum hydroxide precipitate and when injected form a depot of insoluble antigen at injection site which attracts immune cells and enhance immune response. It is used to raise polyclonal and monoclonal antibodies and is less toxic when compared to Freunds complete adjuvant. Synonyms: Mixture of Aluminum Hydroxide and Magnesium Hydroxide. | |
| Aluminium distearate | Aluminium distearate can be used as an emulsifier in cosmetics and proofing agent. Synonyms: Bis(octadecanoic acid)hydroxyaluminum salt. CAS No. 300-92-5. Molecular formula: C36H72AlO5. Mole weight: 611.949. | |
| Aluminium Magnesium Silicate | Magnesium Aluminum Silicate is a dermatological compatible mineral bulking agent and stabilizer for emulsions, creams, toothpastes, gels, or powder. It is the product of weathering of various feldspars, considered to be the most important rock-forming minerals in the earth's crust. Synonyms: Magnesium Aluminum Silicate; Silicic acid (H4SiO4), aluminum magnesium salt (2:2:1); Aluminosilicic acid (HAlSiO4), magnesium salt; Magnesium aluminosilicate (MgAl2Si2O8); Angast; Magnesium aluminate metasilicate; Magnesium aluminometasilicate; Magnesium aluminosilicate (Mg(AlSiO4)2); Neoalumin S; Neusilin; Neusilin A-AS; Neusilin FH 1; Neusilin FH 2; Neusilin FL 1; Neusilin FL2; Neusilin NFL 2N; Neusilin S 1; Neusilin SG 2; Neusilin SN 2N; Neusilin UFL; Neusilin UFL 2; Neusilin UFL2; Neusilin URF 2; Neusilin US2; Sebumase; Tomita AD 300P; Tomix AD 300NSS. CAS No. 12511-31-8. Molecular formula: MgAl2(SiO4)2. Mole weight: 262.43. | |
| Aluminum Monostearate | Aluminum Monostearate can be used in the preparation of colors for cosmetics and for the packaging of pharmaceuticals. Uses: Paints, inks, greases, waxes, thickening lubricating oils; waterproofing, gloss producer, stabilizer for plastics, food additive.aluminum monostearate is mainly used in microencapsulation and in the manufacture of ointments. aluminum monostearate is used as a viscosity-increasing agent in nonaqueous cosmetic and pharmaceutical formulations. in addition, aluminum monostearate can be used as an emulsion stabilizer in cosmetic emulsions and is used in cosmetics such as mascara, moisturizers, and sunscreens. Synonyms: Aluminum dihydroxide stearate; Stearic acid aluminum dihydroxide salt. Grades: 97%. CAS No. 7047-84-9. Molecular formula: C18H39AlO4. Mole weight: 346.488. | |
| Aluminum phosphate | Cas No. 7784-30-7. | |
| Aluminum phthalocyanine disulfonate | Aluminum phthalocyanine disulfonate sodium, also known as AlPcS2 disodium or AlS2Pc or AlPcS(2a), is a potent photosensitizer, and is potentially useful in cancer sonodynamic therapy and cancer photodynamic therapy. Aluminum phthalocyanine disulfonate is a mixture of regional isomers, in which sulfonate group can be in 3- or 4- position in phenyl ring. Aluminum phthalocyanine disulfonate is also a Coloring Agent; Dermatologic Agent; Fluorescent Dye; Indicators and Reagent; Luminescent Agent; Photosensitizing Agent; Radiation-Sensitizing Agent. Synonyms: Aluminate(2-), chloro[29H, 31H-phthalocyanine-C, C-disulfonato(4-)-κN29, κN30, κN31, κN32]-, sodium(1:2); Aluminum phthalocyanine disulfonate disodium; AlPcS(2a), AlPcS2; AlS2Pc; ClAlPcS2 Clalpcs; Disulfonated aluminum phthalocyanine; Al(III) Phthalocyanine chloride disulfonate disodium. Grades: 98%. CAS No. 68637-19-4. Molecular formula: C32H16AlClN8O6S2. Mole weight: 779.05. | |
| Alvameline | Alvameline, also known as Lu25-109, is a partial M1agonist and M2/M3 antagonist that was progressed into clinical studies for the treatment of Alzheimer's disease and Urinary incontinence but was subsequently discontinued. Synonyms: 5-(2-ethyltetrazol-5-yl)-1-methyl-3,6-dihydro-2H-pyridine; 5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine tartrate; LU 25-109; LU 25-109-T; LU-25-109-T. CAS No. 120241-31-8. Molecular formula: C9H15N5. Mole weight: 193.25. | |
| Alvelestat | Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE). Synonyms: AZD9668; AZD-9668; AZD 9668; MPH966; MPH 966; MPH-966; Alvelestat. Grades: 0.98. CAS No. 848141-11-7. Molecular formula: C25H22F3N5O4S. Mole weight: 545.537. | |
| Alvimopan dihydrate | Alvimopan dihydrate is a novel, orally available peripherally restricted opioid antagonist with low systemic absorption. It accelerates the gastrointestinal recovery period with most common side effects in chronic pain patients with OBD were abdominal pai. Synonyms: 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid;dihydrate ADL 8-2698 ADL8-2698 alvimopan alvimopan anhydrous anhydrous alvimopan Entereg LY 246736 LY-246736 LY246736 trans-3,4-dimethyl-4-(3-hydroxyph. CAS No. 170098-38-1. Molecular formula: C25H32N2O4.2H2O. Mole weight: 460.57. | |
| Alvimopan monohydrate | The monohydrate salt form of Alvimopan could be commonly used in postoperative recovery of gastrointestinal for acting as a mu-opioid receptor (PAM-OR) antagonist with IC50: 1.7 nM. Uses: The monohydrate salt form of alvimopan could be commonly used in postoperative recovery of gastrointestinal for acting as a mu-opioid receptor (pam-or) antagonist. Synonyms: UNII-28LAR2REDG; 28LAR2REDG; DTXSID30160641; 3078AH; 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid;hydrate. Grades: 98%. CAS No. 1383577-62-5. Molecular formula: C25H34N2O5. Mole weight: 442.55. | |
| ALX 40-4C acetate | ALX 40-4C acetate is a small peptide inhibitor of the chemokine receptor CXCR4. It inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1. Molecular formula: C58H117N37O12. Mole weight: 1524.79. | |
| ALX 5407 hydrochloride | The hydrochloride salt form of ALX 5407, which has been found to be an inhibitor of the glycine transporter GlyT1 and could probably be useful in some neuropsychiatric disorders. Synonyms: ALX 5407 hydrochloride; ALX-5407 hydrochloride; ALX5407 hydrochloride; N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride. Grades: ≥98% by HPLC. CAS No. 200006-08-2. Molecular formula: C24H24FNO3.HCl. Mole weight: 429.92. | |
| Alytesin | Alytesin is an amphibian bombesin-like peptide originally isolated from the skin of the European amphibian, alytes obstetricans. It has biological activity very similar to bombesin. It could cause rat uterine contraction, intestinal contraction, gastric acid secretion and hypertension in vivo in the dog. It also adjusts thermoregulation following central administration in vivo. Synonyms: Alytesin; 31078-12-3; CID 16131139; XGRLGTQWAVGHLM; Alytesin (trifluoroacetate salt); BDBM85497; DTXSID40185027; Pgly-arg-leu-gly-thr-gln-trp-ala-val-gly-his-leu-met-NH2; AKOS024456835; AKOS040764257; CAS_31078-12-3; HY-103276; CS-0026803; J-018236. CAS No. 31078-12-3. Molecular formula: C68H106N22O17S. Mole weight: 1535.78. | |
| AM-0466 | AM-0466 is a potent and selective Nav1.7 inhibitor (IC50 = 0.020 nM). It exhibited an effective activity in a NaV1.7-dependent model of histamine-induced pruritus (itch) and also in a capsaicin-induced nociception model of pain. Synonyms: AM 0466; AM0466. CAS No. 1642113-59-4. Molecular formula: C27H19F3N4O4S. Mole weight: 552.52. | |
| AM 0902 | AM 0902 is an effective and selective TRPA1 antagonist and has been found to exhibit activities in biological pathways associated with pain. Synonyms: AM-0902; AM 0902; AM0902. 1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one. Grades: ≥98% by HPLC. CAS No. 1883711-97-4. Molecular formula: C17H15ClN6O2. Mole weight: 370.79. | |
| AM-114 | AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome. In addition, AM-114 shows anticancer activity, It can inhibit cell growth in human colon cancer HCT116 p53+/+ cells. Uses: Anticancer. Synonyms: AM-114; AM 114; AM114; Proteasome Inhibitor IX; ( (1Z, 1'Z)- (1-methyl-4-oxopiperidine-3, 5-diylidene)bis (methanylylidene))bis (4, 1-phenylene))diboronic acid. Grades: 98%. CAS No. 856849-35-9. Molecular formula: C20H21B2NO5. Mole weight: 377.01. | |
| AM 1172 | AM 1172, an AEA analogue, has been found to be an anandamide uptake inhibitor as well as a cannabinoid receptor partial agonist. Synonyms: AM 1172; AM1172; AM-1172; N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide. Grades: ≥98% by HPLC. CAS No. 251908-92-6. Molecular formula: C27H39NO2. Mole weight: 409.60. | |
| AM 12 | AM 12 is a TRPC5 inhibitor with an IC50 value of 0.28 μM, which exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Synonyms: 2-(2-Bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one. Grades: ≥97%. Molecular formula: C15H9BrO5. Mole weight: 349.14. | |
| AM1241 | AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor. Synonyms: AM 1241; AM-1241; (1-(Methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole); (R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole. Grades: >98%. CAS No. 444912-48-5. Molecular formula: C22H22IN3O3. Mole weight: 503.33. | |
| AM 1714 | AM 1714, a synthetic cannabimimetic indole derivative, is a potent and selective agonist for the cannabinoid receptor. Uses: A potent and selective agonist for the cannabinoid receptor. Synonyms: AM-1714; AM 1714; AM1714; UNII-E3OY6PCU04; 6H-Dibenzo(b,d)pyran-6-one, 3-(1,1-dimethylheptyl)-1,9-dihydroxy-. Grades: ≥98%. CAS No. 335371-37-4. Molecular formula: C22H26O4. Mole weight: 354.44. | |
| AM-2099 | AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 (IC50 = 0.16 μM) with excellent selectivity against hNav1.5 (IC50 > 30 uM). Synonyms: 4-[2-methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamide; AM-2099; AM2099; AM 2099. CAS No. 1443373-17-8. Molecular formula: C19H13F3N4O3S2. Mole weight: 466.46. | |
| AM-2394 | AM-2394 is a selective Glucokinase agonist (GKA), It activates GK with an EC50 value of 60 nM. AM-2394 increases the affinity of GK for glucose by approximately 10-fold. It shows moderate clearance and good oral bioavailability in animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. Uses: Diabetes. Synonyms: AM-2394; AM 2394; AM2394; 1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea. Grades: 98%. CAS No. 1442684-77-6. Molecular formula: C22H25N5O4. Mole weight: 423.47. | |
| AM251 | AM251 block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain. Synonyms: AM251; AM 251; AM-251. Grades: >98%. CAS No. 183232-66-8. Molecular formula: C22H21Cl2IN4O. Mole weight: 555.24. | |
| AM 281 | AM 281 has been found to be a CB1 selective receptor cannabinoid antagonist. Synonyms: AM281; AM 281; AM-281; 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide. Grades: ≥99% by HPLC. CAS No. 202463-68-1. Molecular formula: C21H19Cl2IN4O2. Mole weight: 557.22. | |
| AM-36 | AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotective agent with anti-oxidant activity, in neuronal cell cultures, AM-36 inhibited toxicity induced by N-methyl-D-aspartate (NMDA) and the sodium channel opener veratridine and, in addition, inhibited veratridine-induced apoptosis. Synonyms: 2,6-ditert-butyl-4-[[4-[2-(4-chlorophenyl)-2-hydroxyethyl]piperazin-1-yl]methyl]phenol; AM-36; AM 36; AM36; UNII-08OBY024NY; SCHEMBL12311270; CNSB 002; CNSB-002; CNSB002. Grades: >98%. CAS No. 199467-52-2. Molecular formula: C27H39ClN2O2. Mole weight: 459.06. | |
| AM 4113 | AM4113 has been found to be a CB1 antagonist and could be used in studies of some neuronal dendritic abnormalities diseases. Synonyms: AM 4113; AM-4113; AM4113; 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide. Grades: ≥98% by HPLC. CAS No. 614726-85-1. Molecular formula: C17H12Cl3N3O. Mole weight: 380.66. | |
| AM4668 | AM4668 is a potent and selective G-protein coupled receptor 40(GPR40) agonist with EC50 value of 3.6 nM in an IP3 assay in GPR40 transfected A9 cells. It is more potent than AMG 837 and possesses excellent pharmacokinetic properties across species. It could reduce the plasma glucose levels in an OGTT study in human GPR40 knock-in mice. It inhibits insulin secretion from isolated pancreatic islets. Uses: Am4668 could reduce the plasma glucose levels in an ogtt study. it inhibits insulin secretion from isolated pancreatic islets. Synonyms: AM-4668; AM 4668; AM4668 ;(S)-3-(isoxazol-3-yl)-3-(4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenyl)propanoic acid;(βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid. Grades: >98 %. CAS No. 1011531-27-3. Molecular formula: C24H19F3N2O4S. Mole weight: 488.48. | |
| AM 6545 | AM 6545 has been found to be a CB1 antagonist and could probably be used as an appetite suppressant. Synonyms: AM 6545; AM6545; AM-6545; 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide. Grades: ≥98% by HPLC. CAS No. 1245626-05-4. Molecular formula: C26H23Cl2N5O3S. Mole weight: 556.46. | |
| AM679 | AM679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM679 has anti-inflammatory effects in animal studies. AM679 also showed potent inhibition of leukotrienes in human blood and in a rodent bronchoalvelolar lavage (BAL) challenge model. Research showed AM679 reduces inflammation in the respiratory syncytial virus-infected mouse eye. Synonyms: AM-679; AM 679; AM679; UNII-65KJ8P7M9D; CHEMBL595092; SCHEMBL503239; 65KJ8P7M9D. Grades: >98%. CAS No. 1206880-66-1. Molecular formula: C40H44N4O5S. Mole weight: 692.87. | |
| AM 92016 hydrochloride | The hydrochloride salt form of AM 92016, which has been found to be a specific blocker of the time dependent delayed rectifier potassium current and probably be useful in antiarrhythmic studies. Synonyms: Methanesulfonamide, N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-, hydrochloride (1:1); Methanesulfonamide, N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-, monohydrochloride; 1-(4-Methanesulfonamidophenoxy)-3-(n-methyl-3,4-dichlorophenylethylamino)-2-propanol hydrochloride. Grades: ≥98% by HPLC. CAS No. 133229-11-5. Molecular formula: C19H24Cl2N2O4S.HCl. Mole weight: 483.84. | |
| AM-9514 | AM-9514 is a glucokinase (GK) activator. It shows a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase is very important in regulating glucose homeostasis. AM-9514 may become a drug candidate for the treatment of type 2 diabetes. Uses: Type 2 diabetes. Synonyms: AM-9514; AM9514; AM 9514; 1-(3-((1-ethyl-1H-pyrazol-5-yl)oxy)-5-(((1r,3s)-3-hydroxy-3-methylcyclobutyl)methyl)pyridin-2-yl)-3-methylurea. Grades: 98%. CAS No. 1442677-18-0. Molecular formula: C18H25N5O3. Mole weight: 359.43. | |
| AMARA peptide acetate | AMARA peptide acetate is a substrate for salt-induced kinase (SIK) and adenosine monophosphate-activated protein kinase (AMPK). Molecular formula: C64H119N27O19S. Mole weight: 1602.89. | |
| Amastatin hydrochloride | Amastatin, also known as 3-amino-2-hydroxy-5-methylhexanoyl-L-valyl-L-valyl-L-aspartic acid, is a naturally occurring, competitive and reversible aminopeptidase inhibitor. Amastatin has originally been isolated from the culture filtrate of Streptomyces sp. ME98-M3 and is a competitive inhibitor of human serum aminopeptidase A (Ki = 1.1 · 10?? M) and of pig kidney leucine aminopeptidase (Ki = 1.6 · 10?? M). Amastatin hydrochloride has been shown to slightly decrease the conversion of angiontensin II to angiotensin III, but significantly increases the potency of angiotensin III and des(Asp1)angiotensin I. Synonyms: BIMI-1803; J-000280; ZX-AFC000547; Amastatin HCl. Grades: ≥95%. CAS No. 100938-10-1. Molecular formula: C21H39ClN4O8. Mole weight: 511.01. | |
| Amatuximab | Amatuximab is a humanized monoclonal antibody directed to mesothelin that kills mesothelin-expressing tumor cells by antibody-dependent cell-mediated cytotoxicity. Amatuximab blocks the binding of mesothelin to CA 125 and thus could be used also as a strategy to prevent tumor metastasis. Synonyms: MORab-009. CAS No. 931402-35-6. | |
| Amauromine | Amauromine is a potent and selective cannabinoid receptor CB1 (Ki = 178 nM; Kb = 66.6 nM) with antibiotic properties. It is a neutral antagonist with no activity at CB2 receptors at concentrations up to 10 μM. It is also an antagonist of GPR18 (IC50 = 3.74 μM). Amauromine has vasodilatory activity. Synonyms: FR 900220; WF 6237; Antibiotic FR 900220. Grades: ≥98%. CAS No. 88360-87-6. Molecular formula: C32H36N4O2. Mole weight: 508.7. | |
| Amaze XT | Amaze XT is an anionic film-forming agent that provides unprecedented retention without sticking or flaking in highly humid conditions. Multifunctional, it can be used either as a fixative or as a thickener/suspension for gels and other styling aids. It is easy to use because it disperses quickly in water, does not require neutralization, and reduces manufacturing time by 80% compared to traditional gel systems. It is a dehydroxanthan gum (National Starch). Synonyms: AMAZE XT polymer. CAS No. 797805-91-5. | |
| Ambenonium | Ambenonium is a long-acting cholinesterase inhibitor used as a treatment of myasthenia gravis. The mechanism of Ambenonium is similar to neostigmine. Synonyms: Win-8077; N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethylbenzenemethanaminium]. CAS No. 7648-98-8. Molecular formula: C28H42Cl2N4O2. Mole weight: 537.57. | |
| Ambenonium dichloride | Ambenonium dichloride is an extremely selective, potent and rapidly reversible inhibitor of acetylcholinesterase (AChE) with IC50 value of 0.000698 μM. It is used in the discovery and design of ApoE4 (apolipoprotein E4) inhibitors. It has biological activity showing against Alzheimer's disease. Uses: Parasympathomimetics. Synonyms: Benzenemethanaminium, N,N'-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-, chloride (1:2); [Oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium chloride]; Ammonium, [oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethyl-, dichloride; Benzenemethanaminium, N,N'-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-, dichloride; Ambenonium chloride; Ambestigmin chloride; Misuran; Mysuran; Mysuran chloride; Mytelase; Mytelase chloride; N,N'-Bis-(2-diethylaminoethyl)oxamide bis-2-chlorobenzylchloride; N,N'-Bis-2-[(2-chlorobenzyl)diethylammonium chloride]-ethyloxamide; Oxamizil; Oxazil; Oxazyl; Win 8077. Grades: ≥99%. CAS No. 115-79-7. Molecular formula: C28H42Cl4N4O2. Mole weight: 608.48. | |
| AMBMP hydrochloride | The hydrochloride salt form of AMBMP, which has been found to be a Wnt canonical signaling activator and could probably be effective in the treatment of muscle dystrophy. Synonyms: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 2095432-75-8. Molecular formula: C19H18N4O3.HCl. Mole weight: 386.84. | |
| AMD-070 | AMD-070 is a potent and selective antagonist of CXCR4 (with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay). Synonyms: (S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; AMD11070; AMD-11070; AMD 11070; AMD-070; AMD 070; AMD070. Grades: ≥98% (HPLC). CAS No. 558447-26-0. Molecular formula: C21H27N5. Mole weight: 349.47. | |
| AMD 3100 octahydrochloride | AMD 3100 octahydrochloride is a high selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively). Uses: Anti-hiv agents. Synonyms: Plerixafor Octahydrochloride; Bicyclam; 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane octahydrochloride. Grades: >98%. CAS No. 155148-31-5. Molecular formula: C28H54N8.8HCl. Mole weight: 794.48. | |
| AMD-3451 | AMD-3451 is a dual CCR5/CXCR4 antagonist. It is the first low-molecular-weight anti-HIV drug with selective interaction between HIV co-receptors CCR5 and CXCR4. Synonyms: 1,4,8,11-Tetraazacyclotetradecane, 1-((2,6-Dichloro-4-Pyridinyl)Methyl)-; 935VV663H3; AMD3451. CAS No. 255383-10-9. Molecular formula: C16H27Cl2N5. Mole weight: 360.3. | |
| AMD 3465 | AMD 3465,a N-pyridinylmethylene monocyclam, is a selective antagonist of CXCL12/CXCR4-mediated interactions including ligand binding and receptor activation. With its enhanced potency against the CXCR4 receptor compared with plerixafor, AMD 3465 has been. Synonyms: N-(pyridin-2-ylmethyl)-1-[4-(1, 4, 8, 11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine; hexahydrobromideAMD 3465 hexahydrobromide185991-07-5185991-24-6AMD3465 6 HBrC24H38N6.6BrHAMD3465; AMD 3465; AMD-3465GENZ-644494 N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylen. Grades: ≥98%. CAS No. 185991-24-6. Molecular formula: C24H38N6. Mole weight: 410.60. | |
| AMD3465 hexahydrobromide | AMD 3465 is a potent and selective antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells. AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50 of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells. MD3465 was even 10-fold more effective as a CXCR4 antagonist, while showing no interaction whatsoever with CCR5. AMD3465 has the potential to mobilize hematopoietic stem cells. Synonyms: AMD3465; GENZ-644494 hexahydrobromide. Grades: ≥95%. CAS No. 185991-07-5. Molecular formula: C24H38N6·6HBr. Mole weight: 896.07. | |
| AMDE-1 | AMDE-1 is a modulator of autophagy activity. It acts by triggering autophagy in an Atg5-dependent manner, recruiting Atg16 to the pre-autophagosomal site and causing LC3 lipidation. Synonyms: AMDE 1; alpha-(3-Chlorophenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridine-2-acetonitrile; Autophagy Modulator with Dual Effect-1. CAS No. 478043-30-0. Molecular formula: C18H8ClF6N3. Mole weight: 415.72. | |
| Ametantrone Acetate | Ametantrone is a topoisomerase II inhibitor of the anthrapyrazole family. It can cause covalent cross-links in DNA, so it can be used as a antineoplastic agent. Uses: Antineoplastic agent. Synonyms: CI-881; CI 881; CI881; NSC 287513; NSC-287513; NSC287513; 1, 4-bis ( (2- ( (2-hydroxyethyl) amino) ethyl) amino) anthracene-9, 10-dione diacetate. Grades: 98%. CAS No. 70711-40-9. Molecular formula: C26H36N4O8. Mole weight: 532.59. | |
| Amezinium methylsulfate | Amezinium methylsulfate, a sympathomimetic drug used for the treatment of low blood pressure, increases the arterial blood pressure and heart rate of anaesthetized animals and of pithed rats by stimulating vascular alpha- and cardiac beta 1-adrenoceptors. Synonyms: Amezinium Metilsulfate; LU-1631; LU 1631; LU1631; Regulton; Risumic. 6-methoxy-1-phenylpyridazin-1-ium-4-amine methylsulfate;AMEZINIUM METHYL SULFATE;SUPRATONIN (GRUNENTHAL);RISUMIC (DAINIPPON);REGULTON (KNOLL);4-amino-6-methoxy-1-phenyl-pyridaziniumethylsulfate;4-amino-6-methoxy-1-phenylpyridazinium-methylsulfat;4-amino-. CAS No. 30578-37-1. Molecular formula: C11H12N3O.CH3O4S. Mole weight: 313.33. | |
| Amflutizole | Amflutizole is a xanthine oxidase inhibitor. It inhibits free radical generation in the ischemic/reperfused rat cerebral cortex. Synonyms: 4-Amino-3-(3-(trifluoromethyl)phenyl)isothiazole-5-carboxylic acid. CAS No. 82114-19-0. Molecular formula: C11H7F3N2O2S. Mole weight: 288.25. | |
| AMG-009 | AMG-009 is an orally active, small molecule dual D prostanoid(DP) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist. It was in preclinical development for the treatment of asthma and allergic rhinitis. It was developed by Amgen Inc. Uses: Amg-009 was in preclinical development for the treatment of asthma and allergic rhinitis. Synonyms: AMG-009; AMG 009; AMG009; 2-[4-[4- (Butylcarbamoyl) -2-[ (2, 4-dichlorophenyl) sulfonylamino]phenoxy]-3-methoxyphenyl]acetic acid;AMG009;Benzeneacetic acid, 4- (4- ( (butylamino) carbonyl) -2- ( ( (2, 4-dichlorophenyl) sulfonyl) amino) phenoxy) -3-methoxy-. Grades: >98 %. CAS No. 1027847-67-1. Molecular formula: C26H26Cl2N2O7S. Mole weight: 581.46. | |
| AMG 21629 | AMG 21629 has been found to be an effective and selective TRPV1 antagonist, which could probably be useful in the treatment of pains associated with cancer and inflammatory diseases. Synonyms: AMG21629; AMG-21629; AMG 21629; 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone. Grades: ≥97% by HPLC. CAS No. 939040-79-6. Molecular formula: C22H19F3N6O3. Mole weight: 472.42. | |
| AMG 333 | AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM for hTRPM8 and IC50 of 20 nM for rTRPM8, which displays high selectivity over other TRP channels (IC50>20 uM, TRPV1/V3/V4/A1). AMG-333 was well-tolerated in 28 day rat and dog preclinical safety studies and advanced to Phase 1 human clinical trials. Synonyms: 6-[[[ (S) - (3-Fluoro-2-pyridinyl) [3-fluoro-4- (trifluoromethoxy) phenyl]methyl]amino]carbonyl]-3-pyridinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1416799-28-4. Molecular formula: C20H12F5N3O4. Mole weight: 453.33. | |
| AMG-458 | AMG 458 is a potent c-Met inhibitor with Ki of 1 nM ~ 2.0 nM. AMG-458 was found to significantly inhibit tumor growth in the NIH3T3/TPR-Met and U-87 MG xenograft models with no adverse effect on body weight. Synonyms: AMG458; AMG 458; 1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide; 2,3-Dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide. Grades: ≥98%. CAS No. 913376-83-7. Molecular formula: C30H29N5O5. Mole weight: 539.58. | |
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