BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Apelin-12 acetate | Apelin-12 induces calcium mobilization in APJ-Gαq16 cells expressing human APJ and inhibits HIV-1 and HIV-2 infection in NP-2/CD4/APJ cells. Apelin-12 inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons. Synonyms: Preproapelin (66-77) (human, bovine, mouse, rat) acetate; (Des-Gln1)-Apelin-13 (human, bovine, mouse, rat) acetate; Apelin Precursor (66-77) (human, bovine, mouse, rat) acetate. Molecular formula: C66H107N21O16S. Mole weight: 1482.77. |  |
| Apelin-13 trifluoroacetate salt | Apelin-13 trifluoroacetate salt is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM. Synonyms: Apelin-13 triTFA. Molecular formula: C75H114F9N23O22S. Mole weight: 1892.89. | |
| Apelin-17 (human, bovine) acetate | Apelin-17 (human, bovine) acetate, secreted by adipocytes, is an endogenous ligand of the G protein-coupled APJ receptor with an EC50 of 2.5 nM. It is an endogenous apelin receptor agonist that potently inhibits forskolin-stimulated cAMP production in vitro. Synonyms: H-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH.CH3CO2H; L-lysyl-L-phenylalanyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine acetic acid. Grades: ≥95%. Molecular formula: C98H160N34O22S. Mole weight: 2198.63. | |
| APHA Compound 8 | APHA Compound 8 is a synthetic HDAC (histone deacetylase) inhibitor, which is in the same structural class as SAHA. The IC50 for mouse HDAC1 is 0.5 μM. It induces histone hyperacetylation, growth inhibition, and terminal cell differentiation. Synonyms: MC-1353; MC1353; MC 1353; APHA-8; APHA Compound 8; Aroyl pyrrole hydroxy amide #8; APHA 8; APHA8. Grades: ≥98%. CAS No. 676599-90-9. Molecular formula: C16H16N2O3. Mole weight: 284.3. | |
| API-1 | Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growt h arrest and apoptosis in human cancer cells expressing constitutively active Akt. Synonyms: API 1; API1; NSC177233; NSC 177233; NSC-177233; 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(beta-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide. Grades: >98%. CAS No. 36707-00-3. Molecular formula: C28H30FN5O2. Mole weight: 337.29. | |
| Apidaecin IB acetate | Apidaecin IB acetate is an insect antimicrobial peptide with a minimum concentration of 8 μM against Escherichia coli (E. coli ML35, o18k1h7 and ATCC 25922). Synonyms: H-Gly-Asn-Asn-Arg-Pro-Val-Tyr-Ile-Pro-Gln-Pro-Arg-Pro-Pro-His-Pro-Arg-Leu-OH.CH3CO2H; glycyl-L-asparagyl-L-asparagyl-L-arginyl-L-prolyl-L-valyl-L-tyrosyl-L-isoleucyl-L-prolyl-L-glutaminyl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-L-histidyl-L-prolyl-L-arginyl-L-leucine acetic acid; 18-L-leucine-Apidaecin Ia acetate; Apidaecin Ib acetate. Grades: ≥95%. Molecular formula: C97H154N32O25. Mole weight: 2168.46. | |
| Apigeninidin chloride | Apigeninidin (Gesneridin) is a chemical compound belonging to the 3-deoxyanthocyanidins and that was found in the Patagonian plant Ephedra frustillata and in the soybean. Apigeninidin is one of the principal pigments found in sorghum. Apigeninidin has antibiotic and antifungal properties. Synonyms: 3-desoxy Pelargonidin. Grades: ≥98%. CAS No. 1151-98-0. Molecular formula: C15H11O4·Cl. Mole weight: 290.7. | |
| AP-III-a4 | AP-III-a4 is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 μM); inhibit cancer cell metastasis in vivo. Synonyms: ENOblock. Grades: >98%. CAS No. 1177827-73-4. Molecular formula: C31H43FN8O3. Mole weight: 594.72. | |
| Apiopaeonoside | Apiopaeonoside is a phenol isolated from the root of Paeonia suffruticosa. Synonyms: Apiopeonoside. Grades: 0.98. CAS No. 100291-86-9. Molecular formula: C20H28O12. Mole weight: 460.43. | |
| Aplaviroc | Aplaviroc is a potent non-competitive CCR5 receptor allosteric antagonist with IC50 of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. Uses: Hiv fusion inhibitors. Synonyms: AK 602. Grades: 98%. CAS No. 461443-59-4. Molecular formula: C33H43N3O6. Mole weight: 577.7. | |
| Aplindore Fumarate | Aplindore Fumarate is a partial agonist selective for the dopamine receptor D2 used in the therapeutic treatment of Parkinson Disease and restless legs syndrome. Synonyms: (2S)-2-[(benzylamino)methyl]-2,3,7,9-tetrahydro-[1,4]dioxino[2,3-e]indol-8-one;(E)-but-2-enedioic acid; (S)-2-(benzylamino-methyl)-2,3,8,9-tetrahydro-7H-1,4-dioxino(2,3-e)indol-8-one fumarate; aplindore fumarate; 189681-70-7(Aplindore free base); DAB-452; DAB 452; DAB452. Grades: >98%. CAS No. 189681-71-8. Molecular formula: C22H22N2O7. Mole weight: 426.42. | |
| Apo-12'-lycopenal | Apo-12'-lycopenal is an innovative biomedical medication, derived from lycopene, an innate chromatic compound abundantly present in botanical produce. This prodigious substance exhibits antioxidant and anti-inflammatory attributes. Grades: >98%. CAS No. 1071-52-9. Molecular formula: C25H34O. Mole weight: 350.54. | |
| Apocholic acid | Apocholic Acid is originally produced from Cholic Acid which is a choleretic produced by and isolated from liver cells. Synonyms: 3alpha,12alpha-Dihydroxy-5beta-chol-8(14)-en-24-oic acid; 5β,8(14)-Cholen-24-oic acid-3α,12α-diol; 3α,12α-Dihydroxy-5β,8(14)-cholen-24-oic acid. Grades: >99%. CAS No. 641-81-6. Molecular formula: C24H38O4. Mole weight: 390.56. | |
| Apocholic Acid (Delta 14 isomer) | Synonyms: 5β-Chol-14-enoic acid-3α,12α-diol. Grades: >99%. CAS No. 2410280-03-2. Molecular formula: C24H38O4. Mole weight: 390.56. | |
| APOL1-IN-1 | APOL1-IN-1 is an inhibitor of apolipoprotein L1 (APOL1), a minor apoprotein component of HDL cholesterol. CAS No. 2446817-72-5. Molecular formula: C21H20FN3O3. Mole weight: 381.4. | |
| Apoptosis Activator 2 | Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. It increases procaspase-9 processing and subsequent caspase-3 activation. It induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM). Synonyms: Apoptosis Activator 2; AAII; N-(3,4-dichlorobenzyl) Isatin. MDK83190; MDK-83190; MDK 83190. CAS No. 79183-19-0. Molecular formula: C15H9Cl2NO2. Mole weight: 306.142. | |
| Aporheine | Cas No. 2030-53-7. | |
| Apparicine | Cas No. 2122-36-3. | |
| Apple Polyphenol | Apple Polyphenol is the general term for polyphenols contained in apples, which has the functions of anti-oxidation and scavenging free radicals. It can be used as cosmetics material. Synonyms: (1R,5R)-6,6-dimethyl-1'-propan-2-ylspiro[bicyclo[3.1.1]heptane-2,3'-cyclobutane]-1'-ol; (1S,5S)-6,6-dimethyl-1'-propan-2-ylspiro[bicyclo[3.1.1]heptane-2,3'-cyclobutane]-1'-ol; 1'-propan-2-ylspiro[bicyclo[3.3.1]nonane-9,3'-cyclobutane]-1'-ol; 1'-propan-2-ylspiro[bicyclo[2.2.2]octane-2,3'-cyclobutane]-1'-ol; Apple, Malus sylvestris, ext; 25281-63-4. Grades: 70%-80%. CAS No. 85251-63-4. Molecular formula: C59H102O4. Mole weight: 875.4. | |
| APR-246 | APR-246 is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity. This agent may work synergistically with other antineoplastic agents. The Wrap53 transcript, a natural p53 antisense transcript, regulates endogenous p53 mRNA levels and additional induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Synonyms: PRIMA-1MET; Prima 1MET; Eprenetapopt; 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one. Grades: 98%. CAS No. 5291-32-7. Molecular formula: C10H17NO3. Mole weight: 199.25. | |
| Apraclonidine | Apraclonidine is a clonidine derivative with relatively selective alpha-2-adrenergic agonistic activity. It is an α2 adrenergic receptor agonist and a weak α1 adrenergic receptor agonist. It enhances aqueous humor uveoscleral outflow and decreases aqueous production by vasoconstriction. It is a sympathomimetic used in glaucoma therapy. It was developed by Alcon and has been listed. Uses: Apraclonidine is a sympathomimetic used in glaucoma therapy. Synonyms: 2-((4-Amino-2, 6-dichlorophenyl)imino)imidazolidine; 2, 6-Dichloro-N-(4, 5-dihydro-1H-imidazol-2-yl)benzene-1, 4-diamine; Iopidine; 4-Aminoclonidine; Apraclonidina; Apraclonidinum; P-aminoclonidine. Grades: 98%. CAS No. 66711-21-5. Molecular formula: C9H10Cl2N4. Mole weight: 245.11. | |
| Apraclonidine hydrochloride | Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine. It is used for the treatment of post-surgical elevated intraocular pressure. It inhibits noradrenaline-stimulated contraction in guinea pig ileum with EC50s of 7.59 nM and rabbit vas deferens with EC50s of 6.76 nM. Uses: Adrenergic alpha-2 receptor agonists. Synonyms: ALO 2145; 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine hydrochloride; Iopidine; p-Aminoclonidine monohydrochloride. Grades: ≥98%. CAS No. 73218-79-8. Molecular formula: C9H10Cl2N4·HCl. Mole weight: 281.6. | |
| Apricoxib | Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. Synonyms: CS-701; CS 701; CS701; TG01; TG 01; TG-01; R-109339, R 109339; R109339; Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-. CAS No. 197904-84-0. Molecular formula: C19H20N2O3S. Mole weight: 356.44. | |
| APRIL from mouse | APRIL (a proliferation-inducing ligand), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. APRIL protein (CD256) can induce proliferation, regulate tumor cell growth, and may participate in mononuclear/macrophage-mediated immune process. APRIL protein has been widely used in the study of lymphatic malignancies. Synonyms: A Proliferating-inducing Ligand; TNFSF13; TRDL-1a; APRIL/TNFSF13 Protein, Mouse; rMuApril/TNFSF13; TNFSF 13; TNFSF-13; CD256. Grades: ≥98% by HPLC. Mole weight: ~21.9 kDa. | |
| APRIL human | APRIL (a proliferation-inducing ligand), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. APRIL protein (CD256) can induce proliferation, regulate tumor cell growth, and may participate in mononuclear/macrophage-mediated immune process. APRIL protein has been widely used in the study of lymphatic malignancies. Synonyms: A Proliferating-inducing Ligand; TNFSF13; TRDL-1a; APRIL/TNFSF13 Protein, Mouse; rMuApril/TNFSF13; TNFSF 13; TNFSF-13; CD256; TALL-2; TALL2; TNLG7B; TRDL-1; UNQ383/PRO715; ZTNF2. Grades: ≥95% by HPLC. Mole weight: ~16.3 kDa. | |
| APRITONE | Synonyms: 2-(3,7-dimethyl-2,6-octadien-1-yl)-Cyclopentanone, 2-(3,7-Dimethyl-2,6-octadienyl)cyclopentanone, 2-(3,7-dimethylocta-2,6-dienyl)cyclopentan-1-one, APRITONE, Contains 99+% FEMA/GRAS # 3829, Cyclopentanone, 2-(3,7-dimethyl-2,6-octadienyl)-, Decenyl Cyclope. Grades: 96.5% (sum of isomers). CAS No. 68133-79-9. Molecular formula: C15H24O. Mole weight: 220.35. | |
| Aprutumab | Aprutumab is a humanized monoclonal antibody directed against FGFR2. Aprutumab has been used in the research of solid tumors. Synonyms: BAY 1179470; BAY-1179470; BAY1179470. CAS No. 1634620-63-5. | |
| APS-2-79 HCl | APS-2-79 is a MAPK antagonist which can modulate KSR-dependent MAPK signalling by antagonizing RAF heterodimerization and the conformational changes required for phosphorylation and activation of KSR-bound MEK. APS-2-79 was found to bind to the KSR active site with an IC50 value of 120 nM, antagonizing MEK (MAPKK) phosphorylation by RAF. Synonyms: APS-2-79 HCl; APS2-79 HCl; APS 2-79 HCl; APS-279 HCl; APS279 HCl; APS 279 HCl; SCHEMBL18153640; AKOS032944984; CS-6151; 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine;hydrochloride. Grades: 99.26 %. CAS No. 2002381-31-7. Molecular formula: C23H21N3O3.HCl. Mole weight: 423.89. | |
| APTAB | APTAB is a fluorescent cationic membrane probe whose location of anthracene-labeled molecules incorporated into model membranes was measured by fluorescence quenching. Synonyms: 3-(9-Anthracene)propyl trimethylammonium bromide. CAS No. 86727-71-1. Molecular formula: C20H24BrN. Mole weight: 358.32. | |
| Aptazapine | Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is a α2-adrenergic receptor antagonist. It is also a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Uses: Antidepressant. Synonyms: CGS 7525 A;2-methyl-1,3,4,14b-tetrahydro-2H,10H-benzo[e]pyrazino[2,1-c]pyrrolo[1,2-a][1,4]diazepine; 71576-41-5 (maleate). Grades: 98%. CAS No. 71576-40-4. Molecular formula: C16H19N3. Mole weight: 253.35. | |
| Aptazapine maleate | Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is a α2-adrenergic receptor antagonist. It is also a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Uses: Antidepressant. Synonyms: (+-)-1,3,4,14b-Tetrahydro-2-methyl-2H,10H-pyrazino(1,2-a)pyrrolo(2,1-c)(1,4)benzodiazepine maleate (1:1). Grades: 98%. CAS No. 71576-41-5. Molecular formula: C16H19N3.C4H4O4. Mole weight: 369.42. | |
| APTO-253 (LOR253 HCl) | Cas No. 1422731-37-0. | |
| APTRA trimethyl ester | APTRA trimethyl ester is a building block for the synthesis of fluorescent indicators. Synonyms: 2-(Carbomethoxy)-methoxy-N,N-bis((carbomethoxy)methyl)aniline. CAS No. 450358-62-0. Molecular formula: C15H19NO7. Mole weight: 325.31. | |
| APTSTAT3-9R | APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. STAT3 has been reported to promote the proliferation, survival, metastasis, immune escape, as well as drug resistance of cancer cells, making it a promising target for various diseases. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets. Treatment of various types of cancer cells with APTSTAT3-9R blocked STAT3 phosphorylation and reduced expression of STAT targets, including cyclin D1, Bcl-xL, and survivin. As a result, APTSTAT3-9R suppressed the viability and proliferation of cancer cells. Furthermore, intratumoral injection of APTSTAT3-9R exerted potent antitumor activity in both xenograft and allograft tumor models. Synonyms: H-DL-His-Gly-DL-Phe-DL-Gln-DL-Trp-DL-Pro-Gly-DL-Ser-DL-Trp-DL-xiThr-DL-Trp-DL-Glu-DL-Asn-Gly-DL-Lys-DL-Trp-DL-xiThr-DL-Trp-DL-Lys-Gly-DL-Ala-DL-Tyr-DL-Gln-DL-Phe-DL-Leu-DL-Lys-Gly-Gly-Gly-Gly-DL-Ser-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-OH; HGFQWPGSWXWENGKWXWKGAYQFLKGGGGSRRRRR RRRR; DL-histidyl-glycyl-DL-phenylalanyl-DL-glutaminyl-DL-tryptophyl-DL-prolyl-glycyl-DL-seryl-DL-tryptophyl-DL-threonyl-DL-tryptophyl-DL-alpha-glutamyl-DL-asparagyl-glycyl-DL-lysyl-DL-tryptophyl-DL-threonyl-DL-tryptophyl-DL-lysyl-glycyl-DL-alanyl-DL-tyrosyl-DL-glutaminyl-DL-phenylalanyl-DL-leucyl-DL-lysyl-glycyl-glycyl-glycyl-glycyl-DL-seryl-DL-arginyl-DL-arginyl-DL-arginyl-DL-arginyl-DL-arginyl-DL-arginyl-DL-arginyl-DL-arginyl-DL-arginine. Grades: 99.31 %. Molecular formula: C223H330N80O51. Mole weight: 4947.51. | |
| AQ-RA 741 | AQ-RA 741 has been found to be a muscarinic M2 receptor antagonist and could probably be used in the development of bronchodilator anti-muscarinic agent. Synonyms: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one. Grades: ≥99% by HPLC. CAS No. 123548-16-3. Molecular formula: C27H37N5O2. Mole weight: 463.62. | |
| AQUAFLOR | Synonyms: 6-Methoxy-2,6-dimethylheptan-1-al, 6-Methoxy-2,6-dimethylheptanal, AQUAFLOR, Heptanal, 6-methoxy-2,6-dimethyl-, Methoxy Melonal, Methoxymelonal. Grades: 95.0%. CAS No. 62439-41-2. Molecular formula: C10H20O2. Mole weight: 172.30. | |
| AR-?08 | AR-08 is an agonist of α2-adrenergic receptor undergone in phase II clinical trials by Arbor Pharmaceuticals for the treatment of attention deficit and hyperactivity disorder (ADHD). Synonyms: AR-08; AR ?08; AR?08; 6-(4,5-dihydro-1H-imidazol-2-ylamino)-7-methyl-3H-benzimidazole-4-carbonitrile; 1H-Benzimidazole-7-carbonitrile, 5-[(4,5-dihydro-1H-imidazol-2-yl)amino]-4-methyl-; 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile. CAS No. 226081-74-9. Molecular formula: C12H12N6. Mole weight: 240.26. | |
| AR17048 | AR17048 is used as a potential antirheumatic drug. Uses: Ar17048 is used as a potential antirheumatic drug. Synonyms: AR-17048; AR 17048; 2-Phenyl-4-(beta-dimethylaminoethyl)-6-methyl-2,3-dihydro-1,4-benzoxazin-3-one. Grades: 98%. CAS No. 65792-35-0. Molecular formula: C19H22N2O2. Mole weight: 310.39. | |
| AR 231453 | AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release. It is Antidiabetic agent. Synonyms: AR231453; AR-231453; AR 231453; AR-231,453; AR231,453; AR231,453. Grades: >98%. CAS No. 733750-99-7. Molecular formula: C21H24FN7O5S. Mole weight: 505.52. | |
| AR-42 | AR-42 is an orally available, broad-spectrum deactylation inhibitor of both histone and non-histone proteins which play an important role in the regulation of gene expression, cell growth and survival. In preclinical studies, AR-42 has demonstrated greater potency and activity in solid and liquid tumors when compared to vorinostat and other deacetylase inhibitors. AR-42 is currently being studied in an investigator-initiated Phase I/IIa clinical study in adult patients with relapsed or refractory multiple myeloma, chronic lymphocytic leukemia or lymphoma. Synonyms: HDAC-42; HDAC42; HDAC 42; OSU-HDAC-42; OSU HDAC 42; AR-42; AR42; AR 42. Grades: 98%. CAS No. 935881-37-1. Molecular formula: C18H20N2O3. Mole weight: 312.37. | |
| AR709 | AR709 is a novel diaminopyrimidine antibiotic. It is currently in development for treatment of community-acquired upper and lower respiratory tract infections. It showed excellent activity against both drug-susceptible and multidrug-resistant pneumococci. Uses: Ar709 is currently in development for treatment of community-acquired upper and lower respiratory tract infections. Synonyms: AR-709; AR 709; 1H-Indole-2-carboxamide, 5-chloro-3-((4-((2,4-diamino-5-pyrimidinyl)methyl)-6,7-dimethoxy-2-benzofuranyl)methyl)-N,N-dimethyl-. Grades: 98%. CAS No. 663214-64-0. Molecular formula: C27H27ClN6O4. Mole weight: 535.00. | |
| arachidonic acid-alkyne | arachidonic acid-alkyne is a modified lipid containing omega terminal alkynes. Synonyms: 5Z,8Z,11Z,14Z-eicosatetraen-19-ynoic acid. Grades: >99%. CAS No. 1219038-32-0. Molecular formula: C20H28O2. Mole weight: 300.44. | |
| Arachidonoyl-2'-fluoroethylamide | Arachidonoyl-2'-fluoroethylamide (2-fluoro AEA) is an analog of anandamide in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. Arachidonoyl 2'-fluoroethylamide is a CB1 receptor agonist with Ki of 26.7 nM for CB1 and Ki of 908 nM for CB2. The in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH. Synonyms: 2'-fluoro AEA; 2'-fluoro Anandamide. Grades: ≥98%. CAS No. 166100-37-4. Molecular formula: C22H36FNO. Mole weight: 349.5. | |
| Arachidonoyl cyclopropylamide | Arachidonoyl cyclopropylamide (ACPA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 2.2 nM for CB1 receptors and 715 nM for CB2 receptors. ACPA inhibits forskolin-induced cAMP accumulation, increases binding of GTPγS to cerebellar membranes, inhibits electrically-evoked contractions of mouse vas deferens and production of hypothermia in mice. Synonyms: ACPA. Grades: ≥98%. CAS No. 229021-64-1. Molecular formula: C23H37NO. Mole weight: 343.6. | |
| Arachidonoyl-N-methyl amide | Anandamide (N-arachidonylethanolamine, AEA) is a brain lipid that binds to cannabinoid receptors with high affinity and mimics the psychoactive effects of plant-derived cannabiniod drugs, which is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid), an essential omega-6 fatty acid. Anandamide inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM. Synonyms: (5Z,8Z,11Z,14Z)-N-methyl-5,8,11,14-Eicosatetraenamide; N-Methylarachidonamide; (all-Z)-N-methyl-5,8,11,14-Eicosatetraenamide. Grades: ≥98%. CAS No. 156910-29-1. Molecular formula: C21H35NO. Mole weight: 317.5. | |
| Arachidonoyl serinol | Arachidonoyl Serinol is an amide bond-containing analogue of 2-arachidonoylglycerol, which exhibited weak CB1 receptor agonistic activity. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain. It is a product of increased inositol phospholipid metabolism. Replacement of the sn-2 oxygen in the glycerol moiety of 2-AG with a nitrogen atom gives arachidonoyl serinol. Arachidonoyl serinol is much more stable than 2-AG. Synonyms: N-arachidonoyl dihydroxypropylamine; 183718-70-9; AA dihydroxypropylamine; (5Z,8Z,11Z,14Z)-N-(1,3-dihydroxypropan-2-yl)icosa-5,8,11,14-tetraenamide; CHEMBL141463; Arachidonoyl Serinol; N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(1,3-dihydroxy-propyl-2-amine); 5,8,11,14-Eicosatetraenamide,N-[2-hydroxy-1-(hydroxymethyl)ethyl]-, (5Z,8Z,11Z,14Z)-; N-[(2-Hydroxy-1-hydroxymethyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; Arachidonoylserinol; CHEBI:183197; QHELXIATGZYOIB-DOFZRALJSA-N; HMS3649C07; BDBM50054465; LMFA08020072; SR-01000946557; SR-01000946557-1; (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid (2-hydroxy-1-hydroxymethyl-ethyl)-amide. Grades: ≥98%. CAS No. 183718-70-9. Molecular formula: C23H39NO3. Mole weight: 377.6. | |
| Arachidonyl serotonin | Arachidonyl serotonin is a dual target agent of transient receptor potential vanilloid-type I (TRPV1) antagonist and fatty acid amide hydrolase (FAAH) inhibitor, which is responsible for inactivation of anandamide and other endogenous cannabinoids. Its IC50 values are 37-40 nM and 5.6 μM for TRPV1 and FAAH respectively. It inhibits the FAAH activity isolated from mouse neuroblastoma cells with an IC50 value of 12 μM. It is a very tight binding, competitive inhibitor of FAAH. It does not inhibit cPLA2 and is essentially devoid of cannabimimetic activity. It was shown to be present in the ileum and jejunum of the gastrointestinal tract and modulate glucagon-like peptide-1 (GLP-1) secretion. It displays strong analgesic activity against both acute and chronic peripheral pain in rodents. Synonyms: AA-5HT; AA5HT; AA 5HT; N-arachidonoyl-serotonin; Arachidonoyl serotonin; N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; AA-5HT; AA5HT; N-arachidonoyl-serotonin; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)icosa-5,8,11,14-tetraenamide. CAS No. 187947-37-1. Molecular formula: C30H42N2O2. Mole weight: 462.67. | |
| Ara-F-NAD+ | Ara-F-NAD+ is an arabino analogue of NAD+. It is a potent, slow-binding CD38 NADase inhibitor, with a Ki of 169 nM. Synonyms: nicotinamide 2'-deoxy-2'-fluororibofuranosyl adenine dinucleotide. CAS No. 133575-27-6. Molecular formula: C21H26FN7O13P2. Mole weight: 665.42. | |
| Arbaclofen placarbil | Arbaclofen placarbil is a prodrug of R-baclofen. It is a GABA B receptor agonist. Arbaclofen was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis. However, development was terminated because of unsuccessful results in phase III clinical trials. Uses: Gerd;spasticity. Synonyms: XP19986; XP-19986; XP 19986; Arbaclofen placarbil; (R) -3- (4-chlorophenyl) -4- ( ( ( (S) -1- (isobutyryloxy) -2-methylpropoxy) carbonyl) amino) butanoic acid. Grades: 98%. CAS No. 847353-30-4. Molecular formula: C19H26ClNO6. Mole weight: 399.87. | |
| Arbutamine | Arbutamine is β-adrenergic receptor originated by SICOR. It is a cardiac stimulant. Arbutamine is a synthetic catecholamine with positive chronotropic and inotropic properties and be applicated in echocardiography and diagnostic coronary angiography. Arbutamine can bind to and activate β-1 adrenergic receptors in the myocardium, so it can increase heart rate and force of myocardial contraction. Arbutamine is an approved drug for the treatment of Coronary artery disease. Uses: Coronary artery disease. Synonyms: Genesa; Arbutaminum; Arbutamina; UNII-B07L15YAEV; CHEBI: 50580; ; 125251-66-3 (Hydrochloride) ; 4-[ (1R) -1-hydroxy-2-[4- (4-hydroxyphenyl) butylamino]ethyl]benzene-1, 2-diol. Grades: 98%. CAS No. 128470-16-6. Molecular formula: C18H23NO4. Mole weight: 317.38. | |
| AR-C 118925XX | AR-C126313, a thiouracil derivative, has been found to be a competitive P2Y2 receptor antagonist and could inhibit P2Y2 receptor-induced β-arrestin translocation in vitro. Synonyms: AR-C126313; ARC126313; AR C126313; 5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide. Grades: ≥97% by HPLC. CAS No. 216657-60-2. Molecular formula: C28H23N7O3S. Mole weight: 537.59. | |
| ARC 239 | ARC239 dihydrochloride is a potent and selective α2 B adrenoceptor antagonist. It is used as an α-adrenoceptor blocking drug. It competitively antagonizes pressor responses to adrenaline and inhibits pressor responses to noradrenaline, tyramine, phenylephrine and dimethylphenylpiperazinium. Uses: Arc239 dihydrochloride is used as an α-adrenoceptor blocking drug. Synonyms: ARC239 dihydrochloride; ARC 239 dihydrochloride; ARC-239 dihydrochloride; 2-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride;AR-C239 Dihydrochloride. Grades: 98%. CAS No. 67339-62-2. Molecular formula: C24H29N3O3. Mole weight: 407.5. | |
| ARC 239 dihydrochloride | The hydrochloride salt form of ARC 239, which has been found to be an α2B adrenoceptor antagonist as well as a norepinephrine-serotonin reuptake inhibitor. Uses: Adrenergic alpha-antagonists. Synonyms: ARC 239 dihydrochloride; ARC239 dihydrochloride; ARC-239 dihydrochloride; 2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride. Grades: ≥98% by HPLC. CAS No. 55974-42-0. Molecular formula: C24H29N3O3.2HCl. Mole weight: 480.43. | |
| AR-C 66096 tetrasodium salt | The sodium salt form of AR-C 66096, which has been found to be a P2Y12 receptor antagonist and could be probably used as an antithrombotic agent. Synonyms: ARL-66096; ARL 66096; ARL66096; 2-(Propylthio)adenosine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 145782-74-7. Molecular formula: C14H18F2N5Na4O12P3S. Mole weight: 703.26. | |
| Arcaine sulfate | Arcaine sulfate is the sulfate salt of arcaine, which is a potent, competitive and novel antagonist of the polyamine site on the NMDA receptor. Synonyms: N,N'-1,4-Butanediylbisguanidine sulfate; 1,4-Diguanidinobutane sulfate salt. Grades: ≥99% by HPLC. CAS No. 14923-17-2. Molecular formula: C6H18N6SO4. Mole weight: 270.31. | |
| ARCC-4 | ARCC-4 is a PROTAC, acting as an androgen receptor degrader. ARCC-4 is a low-nanomolar androgen receptor degrader able to degrade about 95% of cellular androgen receptors. It inhibits prostate tumor cell proliferation, degrades clinically relevant androgen receptor point mutants and unlike enzalutamide, retains antiproliferative effect in a high androgen environment. Synonyms: ARCC-4; 1973403-00-7; (2S,4R)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CHEMBL4540528; SCHEMBL17946930; DUPAJELXESPTNF-PPZGWQTASA-N; AKOS040741162; MS-31874; HY-130492; CS-0108331; EN300-7526556; Z3482428589; O1-(ABM-14 ether), O4-(Methylcarboxamide with AHPC) Butanediol; (2S,4R)-1-[(2S)-2-(2-{4-[(4'-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-[1,1'-biphenyl]-4-yl)oxy]butoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide. Grades: 99%. CAS No. 1973403-00-7. Molecular formula: C53H56F3N7O7S2. Mole weight: 1024.18. | |
| Arctigenin 4'-O-β-gentiobioside | Arctigenin 4'-O-β-gentiobioside is a lignan isolated from Arctigenin. Synonyms: Arctigenin 4'-O-beta-gentiobioside; 41682-24-0; Arctigenin 4'-O-|A-gentiobioside; Arctigenin4'-O-beta-gentiobioside; HY-N2212; AKOS037515072; FS-7090; CS-0019521. Grades: 0.98. CAS No. 41682-24-0. Molecular formula: C33H44O16. Mole weight: 696.69. | |
| Arctium Seed Extract | Arctium Seed Extract is obtained from the roots of the burdock plant of the compositae family. It has the effects of antibacterial and anti-inflammatory, detoxification. It can be used in cosmetics material. Grades: 20%; 10:1. | |
| Arcyriaflavin A | Arcyriaflavin A is a potent dual target agent of calcium/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 4 (CDK4). Its IC50 values are 140 nM and 25 nM for CDK4 and CaMKII respectively, which is selective over protein kinase A (PKA) and PKC in vitro. It inhibits proliferation of HCT116 and NCI H460 human carcinoma cells and replication of human cytomegalovirus (HCMV) in vitro. It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs). Synonyms: Arcyriaflavin A; Arcyriaflavin-A; 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; 6,7,12,13-Tetrahydro-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione; Maleimide Indolocarbazole. Grades: ≥98% by HPLC. CAS No. 118458-54-1. Molecular formula: C20H11N3O2. Mole weight: 325.32. | |
| ARD-2128 | ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor degrader. It effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. Synonyms: Benzamide, N-[trans-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]methyl]-1-piperazinyl]-; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-4-(4-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperazin-1-yl)benzamide; N-[trans-3-(3-Chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]-4-[4-[[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-4-piperidinyl]methyl]-1-piperazinyl]benzamide. Grades: 99%. CAS No. 2222111-87-5. Molecular formula: C45H50ClN7O6. Mole weight: 820.37. | |
| ARD-2585 | ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor for the treatment of advanced prostate cancer. Synonyms: Benzamide, N-[trans-4-[(3-chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-azetidinyl]-1-piperazinyl]-; N- ( (1r, 4r)-4- ( (3-chloro-4-cyanophenyl) (methyl)amino)cyclohexyl)-4- (4- (1- (2- (2, 6-dioxopiperidin-3-yl)-1, 3-dioxoisoindolin-5-yl)azetidin-3-yl)piperazin-1-yl)benzamide; N-[trans-4-[(3-Chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-azetidinyl]-1-piperazinyl]benzamide; ARD 2585; ARD2585. CAS No. 2757422-79-8. Molecular formula: C41H43ClN8O5. Mole weight: 763.28. | |
| ARD-266 | ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines (DC50s = 0.2-1 nM). Synonyms: 2-Pyrrolidinecarboxamide, N- [ (1S) -3- [4- [2- [4- [ [ [trans-3- (3-chloro-4-cyanophenoxy) -2, 2, 4, 4-tetramethylcyclobutyl] amino] carbonyl] phenyl] ethynyl] -1-piperidinyl] -3-oxo-1-phenylpropyl] -4-hydroxy-1- [ (2R) -3-methyl-2- (3-methyl-5-isoxazolyl) -1-oxobutyl] -, (2S,4R)-; (2S, 4R) -N- ( (S) -3- (4- ( (4- ( ( (1r, 3r) -3- (3-chloro-4-cyanophenoxy) -2, 2, 4, 4-tetramethylcyclobutyl) carbamoyl) phenyl) ethynyl) piperidin-1-yl) -3-oxo-1-phenylpropyl) -4-hydroxy-1- ( (R) -3-methyl-2- (3-methylisoxazol-5-yl) butanoyl) pyrrolidine-2-carboxamide; (2S, 4R) -N- [ (1S) -3- [4- [2- [4- [ [ [trans-3- (3-Chloro-4-cyanophenoxy) -2, 2, 4, 4-tetramethylcyclobutyl] amino] carbonyl] phenyl] ethynyl] -1-piperidinyl] -3-oxo-1-phenylpropyl] -4-hydroxy-1- [ (2R) -3-methyl-2- (3-methyl-5-isoxazolyl) -1-oxobutyl] -2-pyrrolidinecarboxamide. Grades: ≥95%. CAS No. 2666951-70-6. Molecular formula: C52H59ClN6O7. Mole weight: 915.51. | |
| ARD-69 | It is a highly potent PROTAC degrader of androgen receptor (AR), which can reduce AR protein level in prostate cancer cell lines and effectively inhibit AR regulated gene expression. It effectively inhibits the growth of AR positive prostate cancer cells. Synonyms: N- [ (1-Fluorocyclopropyl) carbonyl] -3-methyl-L-valyl- (4R) -N-{ (1S) -3-{4- [ (4-{ [trans-3- (3-chloro-4-cyanophenoxy) -2, 2, 4, 4-tetramethylcyclobutyl] carbamoyl}phenyl) ethynyl] -1, 4'-bipiperidin-1'-yl}-1- [4- (4-methyl-1, 3-thiazol-5-yl) phenyl] -3-oxopropyl}-4-hydroxy-L-prolinamide; L-Prolinamide, N- [ (1-fluorocyclopropyl) carbonyl] -3-methyl-L-valyl-N- [ (1S) -3- [4- [2- [4- [ [ [trans-3- (3-chloro-4-cyanophenoxy) -2, 2, 4, 4-tetramethylcyclobutyl] amino] carbonyl] phenyl] ethynyl] [1, 4'-bipiperidin] -1'-yl] -1- [4- (4-methyl-5-thiazolyl) phenyl] -3-oxopropyl] -4-hydroxy-, (4R)-; (2S, 4R) -N- [ (1S) -3- [4- [4- [2- [4- [ [ (1r, 3r) -3- (3-chloro-4-cyanophenoxy) -2, 2, 4, 4-tetramethylcyclobutyl] carbamoyl] phenyl] ethynyl] piperidin-1-yl] piperidin-1-yl] -1- [4- (4-methyl-1, 3-thiazol-5-yl) phenyl] -3-oxopropyl] -1- [ (2S) -2- [ (1-fluorocyclopropanecarbonyl) amino] -3, 3-dimethylbutanoyl] -4-hydroxypyrrolidine-2-carboxamide; ARD69; ARD 69. Grades: ≥95%. CAS No. 2316837-10-0. Molecular formula: C62H74ClFN8O7S. Mole weight: 1129.82. | |
| ardisiacrispin A | Ardisiacrispin A could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule. It was cytotoxic toward HepG2 cancer cell. Synonyms: DeglucocyclaMin I; Saxifragifolin B; Deglucocyclamin; LTS 4. Grades: >98%. CAS No. 23643-61-0. Molecular formula: C52H84O22. | |
| Ardisiacrispin B | Ardisiacrispin B is found in the herbs of Ardisia crenata, it shows cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death. Grades: > 95%. CAS No. 112766-96-8. Molecular formula: C53H86O22. Mole weight: 1075.4. | |
| Ardisicrenoside A | Ardisicrenoside A is found in Ardisia crenata, used as reference standard. Synonyms: Ardisiacrenoside A. Grades: > 95%. CAS No. 160824-52-2. Molecular formula: C53H88O22. Mole weight: 1077.5. | |
| Arecaidine | Arecaidine is found in the fruits of Areca catechu, it has tumorgenicity. Synonyms: Methylguvacine; N-Methylguvacine. Grades: > 95%. CAS No. 499-04-7. Molecular formula: C7H11NO2. Mole weight: 141.17. | |
| Arecaidine hydrochloride | Arecaidine hydrochloride is an alkaloid and may have carcinogenesis. Synonyms: 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid hydrochloride. Grades: 98%. CAS No. 6018-28-6. Molecular formula: C7H12ClNO2. Mole weight: 177.6. | |
| Arecaidine propargyl ester tosylate | Arecaidine propargyl ester tosylate is a potent muscarinic receptor agonist. It displays some selectivity for cardiac versus ileal M2 receptors. Synonyms: N-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid propargyl ester tosylate. CAS No. 147202-94-6. Molecular formula: C17H21NO5S. Mole weight: 351.42. | |
| Arenobufagin | Arenobufagin is a bufanolide steroid isolated from the Argentine toad Bufo arenarum. This compound exhibits anticancer chemotherapeutic and anti-angiogenic properties, but is also cardiotoxic, inhibiting cardiovascular Na+/K+ pumps. Synonyms: Arenobufagin; HY-N0876; CS-3693; FT-0698437; HYN0876; CS3693; FT0698437; HY N0876; CS 3693; FT 0698437. Grades: >98%. CAS No. 464-74-4. Molecular formula: C24H32O6. Mole weight: 416.51. | |
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