BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| [Asn1,Val5]-Angiotensin II | [Asn1,Val5]-Angiotensin II, an octapeptide amide of bovine angiotensin II, is used to increase blood pressure through vasoconstriction. It is a potent vasoconstrictor and a cardiac activator. Uses: Vasoconstrictor agents. Synonyms: Angiotensin amide; Angiotensin; Angiotensinamide; Hypertensine; NSC 107678; 1-L-Asparagine-5-L-valineangiotensin II; Alanine, N-[1-[N-[N-[N-[N-(N2-L-asparaginyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-valyl]-L-histidyl]-L-prolyl]-3-phenyl-, L-; 1-L-Asn-5-L-Val-angiotensin II; 1-L-Asparagine-5-L-valine angiotensin II; 1-Asn2-5-Val-angiotensin II; 1-α-Asparagine-5-valine-angiotensin II; 5-L-Valine-angiotensin II amide; 5-Valine angiotensin amide II; 5-Valine angiotensin II amide; Angiotensin II (Oncorhynchus mykiss); Angiotensin II amide; Angiotensin II amide 5-valine; Hypertensin; Hypertensinamide; Ipertensina; Rainbow trout angiotensin II; Val-Hypertensin-II-asp-β-amide; Val5-angiotensin II amide. Grade: >98%. CAS No. 53-73-6. Molecular formula: C49H70N14O11. Mole weight: 1031.17. |  |
| [Asn1,Val5]-Angiotensin II acetate | [Asn1,Val5]-Angiotensin II acetate, an octapeptide amide of bovine angiotensin II, is used to increase blood pressure through vasoconstriction. It is a potent vasoconstrictor and a cardiac activator. Synonyms: H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH.CH3CO2H; L-asparagyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine acetic acid; Angiotensin II, 1-L-asparagine-5-L-valine-, acetate (1:1); 1-L-Asn-5-L-Val-angiotensin II acetate; Angiotensin II-5-valine-amide acetate; Hypertensin acetate; Hypertensinamide acetate; 1-L-Asparagine-5-L-valine angiotensin II acetate; Angiotensin amide acetate. Grade: ≥95%. CAS No. 1233495-09-4. Molecular formula: C51H74N14O13. Mole weight: 1091.24. | |
| (Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676) | (Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676), a peptide substrate used to determine β-secretase activity, corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Synonyms: (Asn670,Leu671)-APP770 (667-676); H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-OH; L-seryl-L-alpha-glutamyl-L-valyl-L-asparagyl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginine; (6S,9S,12S,15S,18S,21S,24S,27S,30S)-1-amino-24-(2-amino-2-oxoethyl)-30-((S)-2-amino-3-hydroxypropanamido)-9-benzyl-12-(2-carboxyethyl)-18-(carboxymethyl)-1-imino-21-isobutyl-27-isopropyl-15-methyl-8,11,14,17,20,23,26,29-octaoxo-2,7,10,13,16,19,22,25,28-nonaazadotriacontane-6,32-dicarboxylic acid. Grade: ≥90%. CAS No. 186142-28-9. Molecular formula: C50H78N14O19. Mole weight: 1179.24. | |
| [Asp371]-Tyrosinase (369-377), human | It is derived from tyrosinase, a peptide fragment that controls melanin production and has been used to develop tumor-targeted vaccines with mixed efficacy. Synonyms: Tyrosinase Fragment 369-377 human; CMM8; OCA1A; OCAIA; SHEP3; TYR; Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val; L-tyrosyl-L-methionyl-L-alpha-aspartyl-glycyl-L-threonyl-L-methionyl-L-seryl-L-glutaminyl-L-valine. Grade: ≥95%. CAS No. 168650-46-2. Molecular formula: C42H66N10O16S2. Mole weight: 1031.16. | |
| (Asp76)-pTH (39-84) (human) | Asp76-pTH (39-84) (human) is a synthetic peptide widely utilized in the biomedical sector exhibiting its prowess as a potent receptor antagonist for parathyroid hormone (PTH), exerting pivotal influence over the intricate dynamics of calcium and phosphate metabolism. Synonyms: H-Ala-Pro-Leu-Ala-Pro-Arg-Asp-Ala-Gly-Ser-Gln-Arg-Pro-Arg-Lys-Lys-Glu-Asp-Asn-Val-Leu-Val-Glu-Ser-His-Glu-Lys-Ser-Leu-Gly-Glu-Ala-Asp-Lys-Ala-Asp-Val-Asp-Val-Leu-Thr-Lys-Ala-Lys-Ser-Gln-OH; 39-84-Parathormone (human); L-Alanyl-L-prolyl-L-leucyl-L-alanyl-L-prolyl-L-arginyl-L-α-aspartyl-L-alanylglycyl-L-seryl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-lysyl-L-lysyl-L-α-glutamyl-L-α-aspartyl-L-asparaginyl-L-valyl-L-leucyl-L-valyl-L-α-glutamyl-L-seryl-L-histidyl-L-α-glutamyl-L-lysyl-L-seryl-L-leucylglycyl-L-α-glutamyl-L-alanyl-L-α-aspartyl-L-lysyl-L-alanyl-L-α-aspartyl-L-valyl-L-α-aspartyl-L-valyl-L-leucyl-L-threonyl-L-lysyl-L-alanyl-L-lysyl-L-seryl-L-glutamine; human parathormone (39-84). Grade: ≥95% by HPLC. CAS No. 79804-72-1. Molecular formula: C211H356N66O73. Mole weight: 4985.55. | |
| Aspartame | Aspartame is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. Uses: Aspartame is a dipeptide compound composed of two amino acids (aspartic acid and phenylalanine) and a methyl ester bond. it was discovered in 1965 and approved for use by the u.s. food and drug administration (fda) in 1981. aspartame is extremely sweet, about 200 times sweeter than sucrose (table sugar), so only a very small amount is needed to achieve the desired sweetness. aspartame is often use. Synonyms: L-α-Aspartyl-L-phenylalanine 2-Methyl Ester; Canderel; Dipeptide Sweetener; E 951; Equal; Finn; L-Aspartame; NutraSweet; Pal Sweet; Palsweet Diet; Sweet Dipeptide; Zero-Cal; α-Aspartame; α-L-Aspartyl-L-phenylalanine Methyl Ester; α-Sweet. Grade: >98%. CAS No. 22839-47-0. Molecular formula: C14H18N2O5. Mole weight: 294.31. | |
| Aspartame Impurity C | A metabolite of Aspartame. Synonyms: 2-Amino-3-Phenylpropanoic Acid; H-DL-Phe-OH; DL-3-Phenylalanine; DLPA. Grade: 98.5-101.5% (Assay by titration). CAS No. 150-30-1. Molecular formula: C9H11NO2. Mole weight: 165.19. | |
| Aspartocin D | Aspartocin D is a minor analogue of the amphomycin complex, a family of lipopeptide antibiotic produced by Streptomyces canus. Aspartocin D has the activity against Gram-positive bacteria with MIC of 0.125 μg/ml for B. subtilis and is presumed to act by inhibiting bacterial cell wall peptidoglycan synthesis, however its bioprofile and potential utility has not been extensively investigated. The antibacterial activity is calcium-dependent, with MICs ranging from 0.06-4 and 0.25-8 μg/ml for B. subtilis and S. aureus, respectively, in the presence of higher (2.5 mM) to lower (0.125 mM) calcium concentrations. Synonyms: N-[(3Z)-9-methyl-1-oxo-3-decen-1-yl]-L-alpha-aspartyl-(2S,3R)-2,3-diaminobutanoyl-(2R)-2-piperidinecarbonyl-(3S)-3-methyl-L-alpha-aspartyl-L-alpha-aspartylglycyl-L-alpha-aspartylglycyl-(2R,3R)-2,3-diaminobutanoyl-L-valyl-L-proline(11→2)-lactam. Grade: ≥95% by HPLC. CAS No. 1562369-96-3. Molecular formula: C56H87N13O20. Mole weight: 1262.37. | |
| Asperfuran | Asperfuran is an antifungal antibiotic produced by Asperfuran oryzae. Asperfuran has fungal activity and can inhibit fungal chitin synthase, but the effect can be completely offset by lecithin. It also has inhibitory effect on HeLa S3 cells and L1210 cells. Synonyms: Asperfuran; 5,7-Benzofurandiol, 2,3-dihydro-2-(1,3-pentadienyl)-, (R-(E,E))-. CAS No. 129277-10-7. Molecular formula: C13H14O3. Mole weight: 218.25. | |
| Asperlin | Asperlin is an antibiotic produced by Aspergillus nidulans CMI 94163. Asperlin has anti-gram-positive bacteria, negative bacteria, mycobacterial activity, and inhibits KB cells. Synonyms: Asperlin; U 13933. Grade: >98%. CAS No. 30387-51-0. Molecular formula: C10H12O5. Mole weight: 212.20. | |
| Aspoxicillin | Aspoxicillin is a semi-synthetic penicillin prepared from 6-aminopenicillanic acid (6-APA) or Amoxicillin. It has a broad antibacterial spectrum and has an effect on Pseudomonas aeruginosa. Synonyms: Aspoxicilina; Aspoxicilline; Aspoxicillinum. Grade: >98%. CAS No. 63358-49-6. Molecular formula: C21H27N5O7S. Mole weight: 493.53. | |
| Asp-Phe | A metabolite of Aspartame. Synonyms: L-Aspartyl-L-phenylalanine. Grade: >98%. CAS No. 13433-09-5. Molecular formula: C13H16N2O5. Mole weight: 280.28. | |
| Astressin | Astressin is a novel potent corticotropin releasing factor (CRF) antagonist. Astressin may be a useful tool to explore functional CRF-dependent physiological pathways in specific brain nuclei. Uses: Neuroprotective agents. Synonyms: (D-Phe12,Nle21·38,Glu30,Lys33)-CRF (12-41) (human, rat); H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu(1)-Ala-His-Lys(1)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2. Grade: ≥95%. CAS No. 170809-51-5. Molecular formula: C161H269N49O42. Mole weight: 3563.16. | |
| Astressin 2B | Astressin 2B is a selective and potent corticotropin-releasing factor receptor 2 (CRF2) antagonist with IC50 values of > 500 nM and 1.3 for CRF1 and CRF2 respectively. It antagonizes CRF2-mediated inhibition of gastric emptying. Synonyms: Cyclo(31-34)[D-Phe11,His12,C(α)MeLeu13,39,Nle17,Glu31,Lys34]Ac-Svg(8-40). Grade: >98%. CAS No. 681260-70-8. Molecular formula: C183H307N49O53. Mole weight: 4041.69. | |
| Asukamycin | Asukamycin, a manumycin-type metabolite, is isolated from Streptomyces nodosus subsp. asukaensis. It exhibits antibiotic properties and inhibits the growth of various tumor cell lines. Synonyms: asukamycin A1; Manumycin F; 2,4,6-Heptatrienamide, 7-cyclohexyl-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-, (2E,4E,6E)-. Grade: >98%. CAS No. 61116-33-4. Molecular formula: C31H34N2O7. Mole weight: 546.61. | |
| Atazanavir Impurity C | An impurity of Atazanavir. Synonyms: (2R,3S)-3-(tert-Boc)amino-1,2-epoxy-4-phenylbutane; N-[(1S)-1-[(2R)-2-Oxiranyl]-2-phenylethyl]-carbamic Acid 1,1-Dimethylethyl Ester; (2R,3S)-(+)-3-tert-Butoxycarbonylamino-1,2-epoxy-4-phenylbutane; [(1S)-1-((2R)-Oxiranyl)-2-phenylethyl]carbamic Acid tert-Butyl Ester. Grade: > 95%. CAS No. 98760-08-8. Molecular formula: C15H21NO3. Mole weight: 263.34. | |
| ATI-2341 | A potent and functionally selective allosteric agonist of CXCR4. Synonyms: ATI 2341; palmitoyl-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH; N-palmitoyl-L-methionyl-glycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-alpha-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine; ATI2341; 1-Oxohexadecyl-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu. Grade: ≥95%. CAS No. 1337878-62-2. Molecular formula: C104H178N26O25S2. Mole weight: 2256.82. | |
| ATI-2341 acetate | ATI-2341 acetate is a potent and functionally selective CXCR4 allosteric agonist that activates Gα1 rather than Gα13. ATI-2341 acetate activates the inhibitory heterotrimer G protein (GI) to promote the inhibition of cAMP production and induce calcium mobilization. Synonyms: palmitoyl-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH.CH3CO2H; N-palmitoyl-L-methionyl-glycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-alpha-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine acetic acid; N-(1-Oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine acetate; ATI 2341 acetate; ATI2341 acetate. Grade: ≥95%. Molecular formula: C106H182N26O27S2. Mole weight: 2316.87. | |
| ATN 161 | ATN-161 is a small peptide antagonist of integrin alpha5beta1 with potential antineoplastic activity. ATN-161 selectively binds to and blocks the receptor for integrin alpha5beta1, thereby preventing integrin alpha5beta1 binding. Synonyms: ATN161; ATN-161; Ac-PHSCN-NH2; N-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-L-asparaginamide. Grade: >98%. CAS No. 262438-43-7. Molecular formula: C23H35N9O8S. Mole weight: 597.65. | |
| Atorvastatin Diepoxide Calcium Salt | An impurity of Atorvastatin, a statin medication used to treat cardiovascular disease. Synonyms: Atorvastatin diepoxide Calcium; 3,7-Dioxa-5-azatricyclo[4.1.0.02,4]heptane-5-heptanoic acid, 4-(4-fluorophenyl)-β,δ-dihydroxy-6-(1-methylethyl)-2-phenyl-1-[(phenylamino)carbonyl]-, calcium salt (2:1), (βR,δR)-; (βR,δR)-4-(4-Fluorophenyl)-β,δ-dihydroxy-6-(1-methylethyl)-2-phenyl-1-[(phenylamino)carbonyl]-3,7-dioxa-5-azatricyclo[4.1.0.02,4]heptane-5-heptanoic acid calcium salt. Grade: ≥95%. CAS No. 1807481-01-1. Molecular formula: C33H34FN2O7.1/2Ca. Mole weight: 1219.34. | |
| Atosiban | Atosiban, a nonapeptide, desamino-oxytocin analogue, is a competitive inhibitor of the hormones oxytocin and vasopressin. It inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Uses: Atosiban is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Synonyms: Antocin II; ORF 22164; RWJ-22164; 1-(3-Mercaptopropanoic Acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin; 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin; Glycinamide, O-ethyl-N-(3-mercapto-1-oxopropyl)-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-ornithyl-, cyclic (1→5)-disulfide; Antocile; Antocin; CAP 449; Tractocile; CAP 476; CAP 581; F 314; RW 22164; deamino-Cys-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bridge: Cys1-Cys6); Deamino-cysteinyl-O4-ethyl-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparagyl-L-cysteinyl-L-prolyl-L-ornithyl-glycinamide (1->6)-disulfide. Grade: 95%. CAS No. 90779-69-4. Molecular formula: C43H67N11O12S2. Mole weight: 994.19. | |
| Atovaquone | Atovaquone is a medication used to treat or prevent pneumocystis pneumonia, toxoplasmosis, malaria, and babesia. Uses: Antipneumocystic. Synonyms: Mepron; Wellvone; Acuvel; 566C80; 566C; BW 566C; 2-(trans-4-(p-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone. Grade: 98%. CAS No. 95233-18-4. Molecular formula: C22H19ClO3. Mole weight: 366.84. | |
| ATP 100mM Solution (Adenosine-5'-triphosphate, trisodium salt) | ATP 100mM Solution (Adenosine-5'-triphosphate, trisodium salt). CAS No. 56-65-6. Molecular formula: C10H13N5Na3O13P3. | |
| ATP-acetyl-desthiobiotin | ATP-acetyl-desthiobiotin is a paramount recompound in the realm of biomedical researchdue to its remarkable potential in scrutinizing intricate protein functionalities. With its unparalleled proclivity for ATP-dependent enzymes, it serves as an invaluable tool for monitoring and discerning the intricacies of ATPases, aTP-binding proteins and ATP-utilizing enzymes. Synonyms: Desthiobiotin-ATP probe; Desthiobiotin-acyl-ATP. Molecular formula: C20H32N7O15P3. Mole weight: 703.43. | |
| Atpenin A5 | Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD. It is an antifungal antibiotic produced by Penicillium sp. and an ubiquinone-binding site inhibitor of succinate dehydrogenase with IC50s of 12 nM for nematode and IC50s of 3.7 nM for mammalian mitochondria. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels. Synonyms: Antibiotic FO-125A5. Grade: ≥95%. CAS No. 119509-24-9. Molecular formula: C15H21Cl2NO5. Mole weight: 366.2. | |
| Atrial Natriuretic Peptide (ANP) (1-28), rat | Atrial natriuretic factor (1-28) (rat) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits the arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Uses: Vasodilator agents. Synonyms: Atrial natriuretic factor (1-28) (rat); rANP; Atrial Natriuretic Peptide rat; Cardiodilatin-126; Atrial Natriuretic Factor (1-28) (mouse, rabbit, rat); rANF (1-28); H-Ser-Leu-Arg-Arg-Ser-Ser-Cys(1)-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys(1)-Asn-Ser-Phe-Arg-Tyr-OH; L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-isole. Grade: ≥95%. CAS No. 88898-17-3. Molecular formula: C128H205N45O39S2. Mole weight: 3062 | |
| (±)-Atropine-[d3] (N-methyl-[d3]) | One of the isotopic labelled form of (±)-Atropine, which could be used as a pesticide poisoning and as a muscle relaxant. Synonyms: (±)-Atropine-d3 (N-methyl-d3). Grade: 95% by HPLC; 98% atom D. CAS No. 1276197-36-4. Molecular formula: C17H20D3NO. Mole weight: 292.39. | |
| ATTO 425-Biotin | ATTO 425 is a new label with high quantum yield (0.90) as well as sufficient stokes shift (excitation maximum 436 nm, emission maximum 484 nm). It is optimized for excitation with argon laser, and is characterized by high photostability. It does nearly not show cis-trans-isomerization, which limits brightness and reproducibility for many other dyes. Uses: Atto fluorescent labels are designed for high sensitivity applications, including single molecule detection. atto labels have rigid structures that do not show any cis-trans-isomerization. thus these labels display exceptional intensity with minimal spectral shift on conjugation. atto 425 biotin is suitable for fluorescence labeling of avidin/streptavidin conjugated molecules. Grade: ≥95.0% (HPCE). Molecular formula: C37H53N5O7S. Mole weight: 711.91. | |
| ATTO 514-Biotin | ATTO 514 is a new hydrophilic fluorescent label with excellent water solubility. The dye exhibits strong absorption, high fluorescence quantum yield and exceptional thermal and photo-stability. Thus ATTO 514 is highly suitable for single-molecule detection applications and high-resolution microscopy such as PALM, dSTORM, STED etc. Additionally the dye highly qualifies to be applied in flow cytometry (FACS), fluorescence in-situ hybridization (FISH) and many more. The fluorescence is excited most efficiently in the range 510-535 nm. A suitable source of excitation is the 514 nm line of the Argon-Ion laser.Biotin conjugates can be used in applications like ELISA or immuno-histochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-conjugates.find more information here. | |
| ATTO 520-Biotin | ATTO 520-Biotin. Uses: Atto 520 is a fluorescent label with high molecular absorption (110.000) and quantum yield (0.90) as well as sufficient stokes shift (excitation maximum 520 nm, emission maximum 542 nm). it does nearly not show cis-trans-isomerisation, which limits brightness and reproducibility for many other dyes. due to an insignificant triplet formation rate it is well suited for single molecule detection applications. can be utilized in applications such as elisa or immuno-histochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-conjugates. atto-520 fluorescent-labeled biotin can be loaded onto magnetic beads coated with streptavidin through specific ligand-receptor interactions. Grade: ≥95.0% (HPCE). Molecular formula: C37H53ClN6O8S. Mole weight: 777.37. | |
| ATTO 594-Biotin | ATTO 594 is a novel fluorescent label belonging to the class of Rhodamine dyes. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Characteristic features of the label are strong absorption, high fluorescence quantum yield, high thermal and photo-stability, excellent water solubility, and very little triplet formation. After coupling to a substrate ATTO 594 carries a net electrical charge of -1.find more information here. Grade: ≥90% (HPCE). | |
| ATTO 610-Biotin | ATTO 610-Biotin. Uses: Atto 610 belongs to a new generation of fluorescent labels invented by atto-tec. the dye is designed for application in the area of life science, e.g. labeling of dna, rna or proteins. characteristic features of the label are strong absorption, high fluorescence quantum yield, high photostability, good water solubility, and very little triplet formation. atto 610 is a ph sensitive product. while practically stable up to ph 8.5, it slowly degrades at higher ph. biotin conjugates can be used in applications like elisa or immunohistochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-conjugates. Grade: ≥85% (HPCE). Molecular formula: C40H57ClN6O7S. Mole weight: 801.43. | |
| ATTO 655-Biotin | ATTO 655-Biotin. Uses: Atto 655 conjugated to biotin is useful for binding to proteins (i.e., avidin and streptavidin). the fluorescent properties include excellent thermal and photo-stability, high quantum yield, strong absorption (663 nm) and fluorescence (684 nm), and low triplet formation. it is a zwitterionic dye, carrying a net electrical charge of zero. electron donors such as guanine and tryptophan can easily quench the fluorescence of this fluorophore. biotin conjugated with atto 655 was applied to assess efficiency of bsa/avidin structures bound to a surface. Grade: ≥95.0% (HPCE). | |
| ATTO 665 Biotin | ATTO 665 is a new fluorescent label closely related to ATTO 647N. It shows extraordinary high fluorescence quantum yield, excellent thermal and photo-stability, outstanding ozone resistance, and very little triplet formation. ATTO 665 is a cationic (charge +1). The dye is moderately hydrophilic. Biotin conjugates can be used in applications like ELISA or immuno-histochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-onjugates.find more information here. Grade: ≥95.0% (HPCE). | |
| ATTO 740-Biotin | ATTO 740 belongs to a new generation of fluorescent labels for the near infrared spectral region. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Characteristic features of the dye are strong absorption and good fluorescence as well as excellent thermal and photo-stability. ATTO 740 is a cationic dye. After coupling to a substrate the dye carries a net electrical charge of +1.ATTO 740 is a pH sensitive product. While practically stable up to pH 7.4 (PBS-buffer), it slowly degrades at higher pH. If exposed to higher pH for coupling purposes, we recommend reducing the pH immediately after completion of the reaction.Biotin conjugates can be used in applications like ELISA or immunohistochemistry, in situ-hybridization, flow cytometry and others, to identify streptavidin, avidin or extravidin-conjugates.find more information here. Grade: ≥90.0% (HPCE). | |
| ATTO MB2-Biotin | ATTO MB2-Biotin is a derivative of the well-known redox dye Methylene Blue. The dye can be reversibly reduced to the Colorless leuko form. Upon oxidation (e.g. with oxygen) the dye recovers, and the absorption is fully restored.The dye is suitable for labeling of DNA, RNA, proteins etc. In common with most ATTO-labels the dye shows a high extinction coefficient.ATTO MB2-Biotin ester is moderately hydrophilic.find more information here. | |
| ATTO Rho101 Biotin | ATTO Rho101 is a new rhodamine dye, based on the well-known laser dye Rhodamine 101. The new label is functionalized for coupling to bio-molecules such as DNA, RNA or proteins. ATTO Rho101 shows extraordinary brightness and photostability.After coupling to a substrate ATTO Rho101 carries a net electrical charge of +1. The dye is moderately hydrophilic.find more information here. | |
| ATTO Rho11 Biotin | ATTO Rho11 Biotin. Uses: Atto rho11 biotin is a new rhodamine dye for coupling to bio-molecules such as dna, rna, proteins etc. the label shows very high fluorescence efficiency and exceptionally high photostability. the dye is moderately hydrophilic. atto rho11 is a cationic dye. after coupling to a substrate the label carries a net electrical charge of +1. biotin conjugates can be used in applications like elisa or immunohistochemistry, in situ hybridization, flow cytometry and others, to identify streptavidin, avidin, or extravidin-conjugates. | |
| ATTO Rho12 Biotin | ATTO Rho12 is a rhodamine dye for application in life sciences, e.g. labeling of DNA, RNA or proteins. The label shows strong absorption, high fluorescence quantum yield, and high photostability.After coupling to a substrate ATTO Rho12 carries a net electrical charge of +1.The dye is moderately hydrophilic. ATTO Rho12 consists of a mixture of three isomers with practically identical absorption and fluorescence properties.find more information here. | |
| ATTO Rho13 Biotin | ATTO Rho13 Biotin is a new rhodamine dye for application in life sciences, e.g. labeling of DNA, RNA or proteins. The label shows strong absorption, high fluorescence quantum yield, and high photostability. After coupling to a substrate ATTO Rho13 Biotin carries a net electrical charge of +1.The dye is moderately hydrophilic. Biotin conjugates can be used in applications like ELISA or immunohistochemistry, in situ-hybridization, flow cytometry and others, to identify streptavidin, avidin or extravidin-conjugates. | |
| ATTO Rho14 Biotin | ATTO Rho14 is a rhodamine featuring a functionality for coupling to biomolecules such as DNA, RNA or proteins. The label shows strong absorption, and extraordinarily high fluorescence quantum yield. In fact ATTO Rho14 is thebrightest label available in this wavelength range. In addition the dye exhibits an exceptionally high photostability.After coupling to a substrate ATTO Rho14 carries a net electrical charge of +1.Absorption and fluorescence are pH-independent in the range of pH 2 to 11, used in typical applications. The dye is moderately hydrophilic.find more information here. | |
| ATTO Rho6G-Biotin | ATTO Rho6G-Biotin is a new rhodamine dye, based on the well-known laser dye Rhodamine 6G. The new label is functionalized for coupling to biomolecules such as DNA, RNA or proteins. ATTO Rho6G-Biotin shows strong absorption, extraordinary high fluorescence quantum yield, high thermal and photo-stability, and very little triplet formation.After coupling to a substrate ATTO Rho6G-Biotin carries a net electric charge of +1.The label is moderately hydrophilic.find more information here. | |
| ATTO Thio12 Biotin | ATTO Thio12 Biotin is a new label closely related to the well-known rhodamines. The dye can be used for labeling of DNA, RNA or proteins. The characteristic feature of the label is high yield of triplet formation.The dye is moderately hydrophilic. ATTO Thio12 Biotin is a cationic dye. After coupling to a substrate the dye carries a net electrical charge of +1.Biotin conjugates can be used in applications like ELISA or immunohistochemistry, in situ-hybridization, flow cytometry and others, to identify streptavidin, avidin or extravidin-conjugates. | |
| Au-PEG-Biotin, MW 550-5k | The functionalized and PEGylated highly concentrated gold nanoparticles have the same narrow size distribution as our non-functionalized particles but carry groups on the surface. Au multiple size options range from 5 nm to 100 nm. PEG molecular weight varies from 550 MW to 5000 MW. Synonyms: Gold Nanoparticles, Au-PEG-Biotin; Spherical Gold Nanoparticle-polyethylene glycol-biotin. Grade: ≥90%. Mole weight: Customizable. | |
| Auramycin A | It is produced by the strain of Streptomyces galilaeus. Auramycin has the ability of anti gram-positive bacteria and tumor, with the LD50 100mg/kg (Mouse, abdominal cavity). Synonyms: methyl (1R,2R,4S)-4-[(2S,4S,5S,6S)-4-dimethylamino-5-[(2S,4S,5R,6S)-4- hydroxy-6-methyl-5-[(2S,6S)-6-methyl-5-oxo-oxan-2-yl]oxy-oxan-2-yl]oxy -6-methyl-oxan-2-yl]oxy-2,5,7-trihydroxy-2-methyl-6,11-dioxo-3,4-dihyd ro-1H-tetracene-1-carboxylate; auramycin A. Grade: 95%. CAS No. 78173-92-9. Molecular formula: C41H51NO15. Mole weight: 797.84. | |
| Auramycin B | It is produced by the strain of Streptomyces galilaeus. Auramycin has the ability of anti gram-positive bacteria and tumor, with the LD50 100mg/kg (Mouse, abdominal cavity). Synonyms: auramycin B. CAS No. 78173-91-8. Molecular formula: C41H49NO15. Mole weight: 795.83. | |
| Aurantiogliocladin | It is produced by the strain of Gliocladium roseum. Aurantiogliocladin has weak activity of anti-gram positive bacteria, negative bacteria and fungal. Synonyms: 2,3-DIMETHOXY-5,6-DIMETHYL-2,5-CYCLOHEXADIENE-1,4-DIONE; 2,3-DIMETHOXY-5,6-DIMETHYL-P-BENZOQUINONE; AURANTIOGLIOCLADIN; 2,3-Dimethoxy-5,6-dimethyl-1,4-benzoquinone. Grade: 95%. CAS No. 483-54-5. Molecular formula: C10H12O4. Mole weight: 196.20. | |
| Aureothin | Aureothin is produced by the strain of Streptomyces thioluteus 4-A-1 and Streptomyces sp. 58. An unusual pyranone metabolite; has broad biological actions including antitumour, antimicrobial and insecticidal activities; a potent inhibitor of helicobacter pylori. Synonyms: Distacin; Mycolutein. Grade: >95% by HPLC. CAS No. 2825-00-5. Molecular formula: C29H26ClF3N2O6. Mole weight: 591. | |
| Aureothricin | Aureothricin is produced by the strain of Streptomyces celluloflavus. It was active against gram-positive bacteria, negative bacteria and Mycobacterium, and intraperitoneal injection could inhibit the increase of ascites in transplanted mice with Aldrin ascites carcinoma. Synonyms: Propionylpyrrothione; Farcinin. Grade: >98% by HPLC. CAS No. 574-95-8. Molecular formula: C9H10N2O2S2. Mole weight: 242.32. | |
| Auristatin F | Auristatin F, a synthetic analog of dolastatin 10, is a cytotoxic tubulin modifier with potent and selective antitumor activity. It is an MMAF analog and cytotoxin in Antibody-drug conjugates. Uses: Adcs cytotoxin. Synonyms: N,N-Dimethyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-L-phenylalanine; L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-; N,N-Dimethyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl}-3-methoxy-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-valinamide. Grade: ≥97% by HPLC. CAS No. 163768-50-1. Molecular formula: C40H67N5O8. Mole weight: 745.99. | |
| Aurodox | It is produced by the strain of Streptomyces goldiniensis var. goldiniensis. Aurodox is a polyketide antibiotic originally isolated from S. goldiniensis, which inhibits bacterial protein biosynthesis by interrupting the functional cycle of Elongation Factor-Tu (EF-Tu). Aurodox is a type 3 secretion system (T3SS) inhibitor and growth promotor in poultry. It is active against Gram-positive bacteria, including B. megaterium, B. anthracis, and M. hominis (MICs = 0.06, 0.6, and 3-10 μg/ml, respectively). Synonyms: Antibiotic X 5108; Goldinodox; Goldinomycin; 1-methyl-Mocimycin; Benzamide; CYT11387. Grade: ≥95%. CAS No. 12704-90-4. Molecular formula: C44H62N2O12. Mole weight: 810.97. | |
| Autocamtide 2 | Autocamtide 2 is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: Autocamtide II; H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-threonyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine. Grade: ≥95%. CAS No. 129198-88-5. Molecular formula: C65H118N22O20. Mole weight: 1527.77. | |
| Autocamtide-2-Related Inhibitory Peptide | Autocamtide-2-related inhibitory peptide is a highly selective, specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM kinase II) with I50 value of 40 nM. It is selective over PKC, PKA and CaM kinase IV. Synonyms: AIP; [Ala9]-Autocamtide 2. Grade: ≥97% by HPLC. CAS No. 167114-91-2. Molecular formula: C64H116N22O19. Mole weight: 1497.74. | |
| Autocamtide-2-related inhibitory peptide, myristoylated | Autocamtide-2-related inhibitory peptide, myristoylated is a CaM kinase II inhibitor. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. It blocks reinstatement of morphine-seeking behavior in vivo by pretreatment. Synonyms: AIP Myristoylated; Myr-AIP. Grade: >98%. CAS No. 201422-04-0. Molecular formula: C78H142N22O20. Mole weight: 1708.12. | |
| Autocamtide-2-related inhibitory peptide, myristoylated acetate | Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor that blocks the reinstatement of morphine-seeking behavior in vivo by pretreatment. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. Synonyms: AIP Myristoylated acetate; Myr-AIP acetate; N2-(1-Oxotetradecyl)-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-alanyl-L-leucine acetate; m-AIP acetate; Myristoylated autocamtide-2-related inhibitory peptide acetate; H-Lys(myristoyl)-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH.CH3CO2H. Grade: ≥95%. Molecular formula: C80H146N22O22. Mole weight: 1768.15. | |
| Avenaciolide | It is produced by the strain of Aspergillus avenaceus. A bicyclic bis-butyrolactone; isolated from aspergillus avenaceu; an antifungal agent; inhibits glutamate transport; an atypical ionophore. Synonyms: Avenaciolid; Furo(3,4-b)furan-2,6(3H,4H)-dione, dihydro-3-methylene-4-octyl- (VAN) (8CI). Grade: >95% by HPLC. CAS No. 20223-76-1. Molecular formula: C15H22O4. Mole weight: 266.33. | |
| Avermectin A2a | Avermectin A2a is produced by the strain of Streptomyces avermitilis. It stimulates nerve cells to release Y-aminobutyric acid (GABA), which blocks the transmission of signals from the central nervous system to the motor nerve. It is not resistant to bacteria and fungi, but has strong activity to nematode parasites such as ancylostoma and Pteria, as well as insects such as flies. Abamectin B1a had the highest activity. Ivermectin obtained by catalytic hydrogenation contains 22,23-dihydroabamectin B1a (above 80%) and 22,23 dioxabamectin B1b(below 20%). Less active than B1a but less toxic. Used as repellent (subcutaneous or oral) for cattle, sheep and pigs, it is also effective against human filariasis. Synonyms: Avermectin A1a; SCHEMBL1681224. CAS No. 50914-15-3. Molecular formula: C49H76O15. Mole weight: 905.12. | |
| Avermectin B1a | It is produced by the strain of Streptomyces avermitilis. Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. It is a macrocyclic lactone that makes up a large component of the anthelimintic Abamectin used to control parasitic nematodes in livestock. It also acts as an insecticide and acaricide. Uses: Active ingredient in some commercial ant bait traps. Synonyms: Ivermectin EP Impurity A; Abamectin B1a; Doramectin Impurity 3. Grade: ≥95%. CAS No. 65195-55-3. Molecular formula: C48H72O14. Mole weight: 873.08. | |
| Avermectin B1b | Avermectin B1b is the minor component of the commercially available anthelmintic marketed as Abamectin. It is used broadly against nematodes, ticks, flies, and ants. Synonyms: Ivermectin EP Impurity B; 5-O-Demethyl-25-de(1-methylpropyl)-25-(1-methylethyl)-avermectin A1a; Doramectin Impurity 2. Grade: ≥95%. CAS No. 65195-56-4. Molecular formula: C47H70O14. Mole weight: 859.05. | |
| Avermectin B2a | Avermectin B2a is produced by the strain of Streptomyces avermitilis. It stimulates nerve cells to release Y-aminobutyric acid (GABA), which blocks the transmission of signals from the central nervous system to the motor nerve. It is not resistant to bacteria and fungi, but has strong activity to nematode parasites such as ancylostoma and Pteria, as well as insects such as flies. Abamectin B1a has the highest activity. Ivermectin obtained by catalytic hydrogenation contains 22 23- dihydroabamectin B1a (above 80%) and 22 23 dioxabamectin B1b (below 20%). Less active than B1a but less toxic. Used as repellent (subcutaneous or oral) for cattle, sheep and pigs, it is also effective against human filariasis. Synonyms: Ivermectin EP Impurity C; (23S)-5-O-demethyl-23-hydroxy-22,23-dihydro-avermectin A1a. CAS No. 65195-57-5. Molecular formula: C48H74O15. Mole weight: 891.09. | |
| Avilamycin | Avilamycin is an antimicrobial agent that is active mainly against Gram-positive bacteria and is used against methicillin-resistant staphylococcus. Uses: Anti-bacterial agents. Synonyms: LY 048740; Maxus; Maxus 100; Maxus 200; Surmax; (2R,3S,4R,6S)-6-(((3a'R,4R,4'R,5S,6R,6'S,7a'R)-6'-(((2S,3R,4R,5S,6R)-2-(((2R,3S,4S,5S,6S)-6-(((2R,3aS,3a'R,6S,6'R,7R,7aR,7'S,7a'R)-7'-acetyl-7'-hydroxy-7-(isobutyryloxy)-6'-methyloctahydro-4H-2,4'-spirobi[[1,3]dioxolo[4,5-c]pyran]-6-yl)oxy)-4-hydroxy-5-methoxy-2-(methoxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3-hydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-4',6,7a'-trimethyloctahydro-4'H-spiro[pyran-2,2'-[1,3]dioxolo[4,5-c]pyran]-5-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-4-hydroxy-2-methoxy-6-methylbenzoate. Grade: > 95%. CAS No. 11051-71-1. Molecular formula: C61H88Cl2O32. Mole weight: 1404.24. | |
| Avilamycin A | Avilamycin A is produced by the strain of Streptomyces viridochromogenes NRRL 2860. It inhibits the binding of amino acid-based tRNA to the bacterial ribosome for 30S subunit and has anti-gram-positive bacterial activity. It has been tried as feed additive in animal feeding. Synonyms: Flambamycin, 23-deoxy-. CAS No. 69787-79-7. Molecular formula: C61H88Cl2O32. Mole weight: 1404.23. | |
| Avilamycin B | Avilamycin B is produced by the strain of Streptomyces viridochromogenes NRRL 2860. It inhibits the binding of amino acid-based tRNA to the bacterial ribosome for 30S subunit and has anti-gram-positive bacterial activity. It has been tried as feed additive in animal feeding. Grade: 95%. CAS No. 73240-30-9. Molecular formula: C59H84Cl2O32. Mole weight: 1376.19. | |
| Avilamycin C | Avilamycin C is produced by the strain of Streptomyces viridochromogenes NRRL 2860. It inhibits the binding of amino acid-based tRNA to the bacterial ribosome for 30S subunit and has anti-gram-positive bacterial activity. It has been tried as feed additive in animal feeding. Synonyms: SCHEMBL6753731. Grade: 95%. CAS No. 69787-80-0. Molecular formula: C61H90Cl2O32. Mole weight: 1406.25. | |
| Aviptadil | Aviptadil Acetate is an analog of vasoactive intestinal polypeptide (VIP) as Vasoactive intestinal peptide receptor agonists for the treatment of erectile dysfunction. Uses: Vasoactive intestinal peptide receptor agonists. Synonyms: H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2. Grade: 98%. CAS No. 40077-57-4. Molecular formula: C147H238N44O42S. Mole weight: 3325.80. | |
| AY-NH2 | AY-NH is a selective proteinase-activated receptor 4 (PAR4) receptor agonist peptide. It stimulates aggregation of rat and human platelets in vitro. It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets. It induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips. It also inhibits calcium mobilization evoked by capsaicin in rat sensory neurons. It increases paw thickness in a rat paw edema inflammation model in vivo. Synonyms: PAR-4 Agonist Peptide, amide; L-Alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide; PAR-4-AP; Proteinase-activated Receptor 4 Activating Peptide. Grade: 98%. CAS No. 352017-71-1. Molecular formula: C34H48N8O7. Mole weight: 680.79. | |
| Azamulin | Azamulin is an azole derivative of pleuromutilin. Azamulin is a highly selective inhibitor of cytochrome P450 3A4 (CYP3A4). Synonyms: Azamulinum. Grade: >99% by HPLC. CAS No. 76530-44-4. Molecular formula: C24H36N4O4S. Mole weight: 476.63. | |
| Azaserine | It is produced by the strain of Streptomyces fragilis 04926. Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. Uses: Antibiotics, antifungal; antibiotics, antineoplastic; antimetabolites; antimetabolites, antineoplastic; carcinogens; immunosuppressive agents. Synonyms: diazoacetate (ester) L-Serine; diazoacetylserine; serine diazoacetate. Grade: 98%. CAS No. 115-02-6. Molecular formula: C5H7N3O4. Mole weight: 173.13. | |
| AZD5582 | AZD5582 is a potent IAP inhibitor, which is a dimeric compound based on the AVPI motif of Smac. AZD5582 binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively). AZD5582 causes cIAP1 degradation and induces apoptosis in the MDA-MB-231 breast cancer cell line at subnanomolar concentrations in vitro. AZD5582 was nominated as a candidate for clinical development. Synonyms: AZD5582; AZD-5582; AZD 5582. Grade: ≥98% by HPLC. CAS No. 1258392-53-8. Molecular formula: C58H78N8O8. Mole weight: 1015.31. | |
| AZD5582 acetate | AZD5582 acetate is a potent IAP inhibitor that binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC50 = 15, 21, and 15 nM, respectively). It causes cIAP1 degradation and induces apoptosis in the MDA-MB-231 breast cancer cell line at subnanomolar concentrations in vitro. Synonyms: AZD 5582 acetate; AZD-5582 acetate; 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide] acetate. Grade: ≥95%. Molecular formula: C60H82N8O10. Mole weight: 1075.36. | |
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