MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Granisetron | Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRL 43694. CAS No. 109889-09-0. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0071. |  |
| Granisetron Hydrochloride | Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRL 43694A. CAS No. 107007-99-8. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0071A. | |
| Grape seed extract | Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 84929-27-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N7072. | |
| Grapiprant | Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E 2 (PGE 2 ). Grapiprant displaces [ 3 H]-PGE 2 (1 nM) binding to dog recombinant EP4 receptor with IC 50 value of 35 nM and K i value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CJ-023423; RQ-00000007; AAT-007. CAS No. 415903-37-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16781. | |
| Grassofermata | Grassofermata is a dual Arf1/Arf6 activation inhibitor. ADP ribosylation factors (Arfs) are members of the Arf family of GTP-binding proteins of the Ras superfamily. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NAV-2729. CAS No. 419547-11-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112473. | |
| Grazoprevir | Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K i s of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively [1] [2]. Grazoprevir inhibits SARS-CoV-2 3CL pro activity [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-5172. CAS No. 1350514-68-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15298. | |
| Grazoprevir hydrate | Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K i s of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively [1] [2]. Grazoprevir hydrate inhibits SARS-CoV-2 3CL pro activity [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-5172 hydrate. CAS No. 1350462-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15298B. | |
| Grazoprevir potassium salt | Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively[1][2]. Grazoprevir potassium salt inhibits SARS-CoV-2 3CLpro activity[3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-5172 potassium salt. CAS No. 1206524-86-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15298A. | |
| Green CMFDA | Green CMFDA is a cell-permeable fluorescent probe with Em of 514 nm and Ex of 485 nm and can be used as a cell tracer. Green CMFDA can be cleaved by non-specific esterases common in living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope[1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: CMFDA. CAS No. 136832-63-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126561. | |
| Gremubamab | Gremubamab (MEDI3902) is a humanized IgG1 kappa anti- PcrV/Psl monoclonal antibody. Gremubamab binds to the PA PcrV protein and Psl exopolysaccharide. Gremubamab has the potential for the research of pseudomonas aeruginosa infections [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MEDI3902. CAS No. 1800381-36-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99649. | |
| Grepafloxacin hydrochloride | Grepafloxacin (OPC-17116) hydrochloride is an oral actively fluoroquinolone antibiotic with potent activity against community-acquired respiratory pathogens including Streptococcus pneumonia. Grepafloxacin hydrochloride has high tissue penetration and a promising pharmacodynamic profile [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OPC-17116 hydrochloride; dl-Grepafloxacin hydrochloride. CAS No. 161967-81-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0147A. | |
| Gresonitamab | Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and CLDN18.2-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma[1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG 910; Anti-Human CD3xClaudin18 2. CAS No. 2413817-97-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99350. | |
| GRGDSP | GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor. Uses: Scientific research. Group: Peptides. CAS No. 91037-75-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0290. | |
| GRGDSPK | GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption[1][2]. Uses: Scientific research. Group: Peptides. Alternative Names: EMD 56574. CAS No. 111119-28-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0322. | |
| Griseofulvin | Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 126-07-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g; 25 g. Product ID: HY-17583. | |
| Griseofulvin (Standard) | Griseofulvin (Standard) is the analytical standard of Griseofulvin. This product is intended for research and analytical applications. Uses: Scientific research. Group: Natural products. CAS No. 126-07-8. Pack Sizes: 50 mg; 100 mg. Product ID: HY-17583R. | |
| Grisnilimab | Grisnilimab (WT1), a IgG2a monoclonal antibody anti-CD7, is a tumor suppressor involved in the etiology of Wilms' tumor. Grisnilimab regulates the transcription of multiple target genes and may participate in the post-transcriptional processing of RNA[1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: WT1. CAS No. 2367001-70-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99650. | |
| GRK2 Inhibitor 1 | GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 24269-96-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123538. | |
| GRK2 Inhibitor 2 | GRK2 Inhibitor 2 is an orally active and selective G protein-coupled receptor kinase 2 (GRK) inhibitor with an IC50 of 19 nM. GRK2 Inhibitor 2 also inhibits Aurora-A with an IC50 of 137 nM. GRK2 Inhibitor 2 can be used in the study of congestive heart failure (HF)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2592436-21-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-156863. | |
| GRK5-IN-2 | GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 of 49.7 ?M. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1642839-27-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136561. | |
| GRK6-IN-1 | GRK6-IN-1 (Compound 18) is the inhibitor for G protein-coupled receptorkinase 6 (GRK6) with an IC50 of 3.8-8 nM. GRK6-IN-1 also inhibits GRK7, GRK5, GRK4 and GRK1 with IC50s of 6.4, 12, 22 and 52 nM, respectively. GRK6-IN-1 has the potential for the research of multiple myeloma[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2677786-61-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142812. | |
| GRL0617 | GRL0617 is a selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro), with an IC50 of 0.6 ?M and a Ki value of 0.49 ?M. GRL0617 also inhibits SARS-CoV with an EC50 of 14.5 ?M. GRL0617 can be used for the research of severe acute respiratory syndrome[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1093070-16-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117043. | |
| Grp94 Inhibitor-1 | Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90?[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2234897-35-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112910. | |
| GS143 | GS143 is a selec-tive I?B? ubiquitination inhibitor with an IC50 of 5.2 ?M for SCF?TrCP1-mediated I?B? ubiquitylation. GS143 sup-presses NF-?B acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 916232-21-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110261. | |
| GS39783 | GS39783 is a positive allosteric modulator (PAM) of GABA B R. Positive modulation of the GABA B R can be used for the research of Nicotine addiction [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 39069-52-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103475. | |
| GS-441524 | GS-441524, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC 50 of 0.78 μM [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1191237-69-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103586. | |
| GS-443902 trisodium | GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 ?M, 5 ?M for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium. CAS No. 1355050-21-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126303C. | |
| GS-9667 | GS-9667 (CVT 3619), a novel N 6 -5'-substituted adenosine analog, is a selective, partial agonist of the A 1 adenosine receptor (A 1 AdoR). GS-9667 binds to adipocyte membranes with high (K H =14 nM) and low (K L =5.4 μM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC 50 values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CVT 3619. CAS No. 618380-90-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19842. | |
| GSK046 | GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. GSK046 has immunomodulatory activity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: iBET-BD2. CAS No. 2474876-09-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136571. | |
| GSK0660 | GSK0660 is a potent PPAR? antagonist with an IC50 of 155 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1014691-61-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12377. | |
| GSK1016790A | GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 942206-85-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19608. | |
| GSK1059615 | GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC 50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 958852-01-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12036. | |
| GSK-1070806 | GSK-1070806 is a CHO-expressed humanized antibody that targets IL-18. GSK-1070806 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 147.38 kDa. The isotype control for GSK-1070806 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Aletekitug. CAS No. 2923284-67-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990591. | |
| GSK-1070916 | GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK-1070916A. CAS No. 942918-07-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70044. | |
| GSK126 | GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC50 of 9.9 nM[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK2816126A. CAS No. 1346574-57-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13470. | |
| GSK-1482160 | GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1?, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1001389-72-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19888. | |
| GSK1521498 free base | GSK1521498 free base is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base has the potential for disorders of compulsive consumption of food, alcohol, and agents [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1007573-18-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115066. | |
| GSK 1562590 hydrochloride | GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT) , with pK i s of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1003878-07-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-108446. | |
| GSK1702934A | GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 924377-85-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111098. | |
| GSK1904529A | GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) , with IC 50 s of 27 and 25 nM, respectively. GSK1904529A shows poor activity ( IC 50 >1 μM) in 45 other serine/threonine and tyrosine kinases. GSK1904529A exhibits anti-tumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1089283-49-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10524. | |
| GSK1940029 | GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor extracted from patent WO/2009060053 A1, compound example 16. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCD inhibitor 1. CAS No. 1150701-66-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19762. | |
| GSK2018682 | GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC 50 s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis. Uses: Scientific research. Group: Signaling pathways. CAS No. 1034688-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-19511. | |
| GSK2033 | GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXR? or LXR?, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1221277-90-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108688. | |
| GSK205 | GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19? ?M for inhibiting TRPV4-mediated Ca2+ influx[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1263068-83-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120691A. | |
| GSK215 | GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC50 of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2743427-26-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132296. | |
| GSK2193874 | GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC50s of 2 nM and 40 nM for rTRPV4 and hTRPV4[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1336960-13-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100720. | |
| GSK2245035 | GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC 50 s of 9.3 and 6.5 for IFNα and TFN&alpha. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1207629-49-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-118250. | |
| GSK2256098 | GSK2256098 is a selective FAK kinase inhibitor, which inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 1224887-10-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100498. | |
| GSK-2256098 hydrochloride | GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416771-10-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100498A. | |
| GSK2256294A | GSK2256294A (GSK 2256294) is a selective and orally active inhibitor of soluble epoxide hydrolase (sEH). GSK2256294A inhibits recombinant human sEH, rat sEH orthologs and murine sEH orthologs with IC50s of 27, 61 and 189 pM, respectively. GSK2256294A can be used for the research of chronic obstructive pulmonary disease (COPD) and cardiovascular disease[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK 2256294. CAS No. 1142090-23-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19644. | |
| GSK2334470 | GSK2334470 is a highly specific and potent inhibitor of PDK1 with an IC50 of 10 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227911-45-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14981. | |
| GSK239512 | GSK239512 is a potent and brain penetrated H 3 receptor antagonist. GSK239512 can be used for the research of mild-to-moderate Alzheimer's disease (AD) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 720691-69-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-106000. | |
| GSK256073 | GSK256073 is a potent, selective and orally active GPR109A agonist and a long-lasting and non-flushing HCA2 full agonist with a pEC50 of 7.5 (human HCA2). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis and has the potential for the study of type 2 diabetes mellitus (T2DM)and dyslipidemia[1][2]. GPR109A: G-protein coupled receptor 109A; HCA2: hydroxy-carboxylic acid receptor 2. Uses: Scientific research. Group: Signaling pathways. CAS No. 862892-90-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119222. | |
| GSK2578215A | GSK2578215A is a potent and highly selective LRRK2 inhibitor, which exhibits IC 50 s of around 10 nM against both wild-type LRRK2 and the G2019S mutant. Uses: Scientific research. Group: Signaling pathways. CAS No. 1285515-21-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13237. | |
| GSK2606414 | GSK2606414 is a cell-permeable and orally available protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) inhibitor with an IC50 of 0.4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1337531-36-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18072. | |
| GSK2636771 | GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with a K i of 0.89 nM and an IC 50 of 5.2 nM, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms. Uses: Scientific research. Group: Signaling pathways. CAS No. 1372540-25-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15245. | |
| GSK2643943A | GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. GSK2643943A has affinity with an IC50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC) [1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2449301-27-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111458. | |
| GSK2656157 | GSK2656157 is a selective and ATP-competitive inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) with an IC50 of 0.9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1337532-29-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13820. | |
| GSK269962A | GSK269962A (GSK 269962) is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively. GSK269962A has anti-inflammatory and vasodilatory activities[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK 269962. CAS No. 850664-21-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15556. | |
| GSK2795039 | GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption[1].GSK2795039 reduces apoptosis[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415925-18-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 100 mg. Product ID: HY-18950. | |
| GSK2798745 | GSK2798745 is a potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 can be used in cardiac and respiratory diseases research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1419609-94-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-19765. | |
| GSK2801 | GSK2801 is a potent, selective, orally active and cell active acetyl-lysine competitive BAZ2A and BAZ2B bromodomains inhibitor with Kd values of 136 nM and 257 nM, respectively. GSK2801 shows >50-fold selectivity for BAZ2A/B over BRD4[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1619994-68-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15658. | |
| GSK2807 Trifluoroacetate | GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3 , with a K i of 14 nM and an IC 50 of 130 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2245255-66-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104009A. | |
| GSK 2830371 | GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1404456-53-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15832. | |
| GSK2837808A | GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 2.6 and 43 nM for hLDHA and hLDHB, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1445879-21-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100681. | |
| GSK2879552 | GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/ KDM1A), with potential antineoplastic activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1401966-69-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18632. | |
| GSK2879552 dihydrochloride | GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1902123-72-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18632A. | |
| GSK2982772 | GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1622848-92-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101760. | |
| GSK2983559 | GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112038A. | |
| GSK2983559 active metabolite | GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1423186-80-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19764. | |
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