MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| GNE-617 | GNE-617 is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC 50 of 5 nM and exhibits efficacy in xenograft models of cancer. Uses: Scientific research. Group: Signaling pathways. CAS No. 1362154-70-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15766. |  |
| GNE-617 hydrochloride | GNE-617 hydrochloride is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC 50 of 5 nM and exhibits efficacy in xenograft models of cancer. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-99-0. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15766A. | |
| GNE-6776 | GNE-6776 is a selective and orally bioavailable USP7 inhibitor[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2009273-71-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107986. | |
| GNE-781 | GNE-781 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1936422-33-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108696. | |
| GNE-7883 | GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. GNE-7883 effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and achieves strong anti-tumor efficacy in vivo. In addition, GNE-7883 effectively overcomes intrinsic and acquired resistance to KRAS (Kirsten rat sarcoma viral oncogene homolog) G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2648450-42-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-147214. | |
| GNE-7915 | GNE-7915 is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1351761-44-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18163. | |
| GNE-8505 | GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620573-48-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-114332. | |
| GNE-987 | GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 incorporates a potent BET binder/inhibitor, a VHL-binding fragment, and a ten methylene spacer moiety. GNE-987 can be used in PROTAC-Antibody Conjugate (PAC)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417371-71-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-129937A. | |
| GNF-2 | GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC50 of 138 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 778270-11-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-11007. | |
| GNF2133 | GNF2133 is a potent, selective and orally active DYRK1A inhibitor with IC 50 s of 0.0062, >50 μM for DYRK1A and GSK3β, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 has the potential for the research of type 1 diabetes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2561414-56-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142295. | |
| GNF351 | GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227634-69-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-102023. | |
| GNF362 | GNF362 is a selective, potent, and orally bioavailable inhibitor of inositol trisphosphate 3 kinase B (Itpkb) with an IC50 of 9 nM. GNF362 also inhibits Itpka and Itpkc with IC50 values of 20 nM and 19 nM, respectively. Inositol trisphosphate 3 kinase B (Itpkb) is a Ca2+-dependent kinase, which phosphorylates the 3 position of Ins (1,4,5) P3 to generate inositol 1,3,4,5-tetrakisphosphate [Ins (1,3,4,5) P4][1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1003019-41-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126750. | |
| GNF-5837 | GNF-5837 is a potent, selective, and orally bioavailable pan- tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC 50 values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC , Tel-TrkB and Tel-TrkA , respectively) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1033769-28-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13491. | |
| GO-203 TFA | GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1222186-26-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1925A. | |
| Go6976 | Go6976 is a Protein Kinase C ( PKC ) inhibitor, with an IC 50 of 20 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 136194-77-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-10183. | |
| Go 6983 | Go 6983 is a pan-PKC inhibitor against for PKC?, PKC?, PKC?, PKC? and PKC? with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Gö 6983; Goe 6983. CAS No. 133053-19-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13689. | |
| Goflikicept | Goflikicept (RPH 104) is a fusion protein that selectively binds and inactivates both circulating IL-1β and IL-1&alpha. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: RPH 104. CAS No. 2416984-26-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99645. | |
| Golcadomide | Golcadomide (CC-99282) is a potent and orally active CRBN E3 ligase modulator (CELMoD). Golcadomide interacts with the CRL4 CRBN E3 ubiquitin ligase substrate receptor CRBN, inducing the recruitment and ubiquitin-mediated proteasomal degradation of the transcription factors Ikaros and Aiolos. Golcadomide shows potential for research in cancer-related fields, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC-99282. CAS No. 2379572-34-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146237. | |
| Gold(?) chloride hydrate (50% Au basis) | Gold(?) chloride hydrate (50% Au basis) (Tetrachloroauric(?) acid hydrate (50% Au basis)) is an organic intermediate that can be used to prepare gold nanoparticles. Gold(?) chloride hydrate (50% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Tetrachloroauric(?) acid hydrate (50% Au basis). CAS No. 27988-77-8. Pack Sizes: 100 mg; 500 mg. Product ID: HY-W073196A. | |
| Gold(III) chloride trihydrate | Gold (III) chloride trihydrate is a reducing agent. Gold (III) chromium trihydrate can be used for chemical synthesis of gold nanoparticles (NP) and spirochromene derivatives [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 16961-25-4. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-W094581. | |
| Golgicide A | Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 [1]. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GCA. CAS No. 1139889-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100540. | |
| Golgicide A-1 | Golgicide A-1 (GCA-1) is a less active cis-diastereomer of Golgicide A (GCA). Golgicide A-1 weakly inhibits mosquito reproduction [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GCA-1. CAS No. 1394285-49-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100540C. | |
| Golidocitinib | Golidocitinib (AZD4205) is a selective JAK1 inhibitor, with an IC 50 of 73 nM, weakly inhibits JAK2 ( IC 50 >14.7 μM), and shows little inhibition on JAK3 ( IC 50 >30 μM) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD4205. CAS No. 2091134-68-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107361. | |
| Golimumab | Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CNTO-148. CAS No. 476181-74-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99111. | |
| Golvatinib | Golvatinib (E-7050) is a potent dual inhibitor of both c-Met and VEGFR2 kinases with IC 50 s of 14 and 16 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E-7050. CAS No. 928037-13-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13068. | |
| Gondoic acid | Gondoic acid (cis-11-Eicosenoic acid), a monounsaturated long-chain fatty acid, is contained in a variety of plant oils and nuts [1]. Uses: Scientific research. Group: Natural products. Alternative Names: cis-11-Eicosenoic acid. CAS No. 5561-99-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W013242. | |
| Goralatide TFA | Goralatide TFA is an inhibitor of cell cycle progression. Goralatide TFA enhances selectivity of hyperthermic purging of human progenitor cells. Goralatide TFA has the potential for the research of leukemia [1]. Uses: Scientific research. Group: Peptides. CAS No. 1796568-94-9. Pack Sizes: 1 mg. Product ID: HY-129283A. | |
| Goserelin acetate | Goserelin acetate (ICI-118630 acetate), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin acetate can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: ICI-118630 acetate. CAS No. 145781-92-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13673A. | |
| Gossypetin | Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activated protein kinase kinase (MKK)3 and MKK6 inhibitor with strongly attenuates the MKK3/6-p38 signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 489-35-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-119917. | |
| Gossypin | Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 652-78-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-125911. | |
| Gossypol | Gossypol binds to Bcl-xL protein and Bcl-2 protein with K i s of 0.5-0.6 μM and 0.2-0.3 mM, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: BL 193. CAS No. 303-45-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13407. | |
| Gossypol (acetic acid) | Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to Bcl-xL protein and Bcl-2 protein with K i s of 0.5-0.6 μM and 0.2-0.3 mM, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: (±)-Gossypol-acetic acid; BL-193 (acetic acid). CAS No. 12542-36-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-17510. | |
| Gossypolone | Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a K i of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4547-72-2. Pack Sizes: 1 mg. Product ID: HY-119734. | |
| Gosuranemab | Gosuranemab (BMS-986168) is a humanised IgG4 anti- tau monoclonal antibody. Gosuranemab binds to human N-terminal tau residues 15-22. Gosuranemab has the potential for the research of alzheimers disease (AD) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BMS-986168; IPN007; BIIB092. CAS No. 1788032-39-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99648. | |
| GOT1 inhibitor-1 | GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 732973-87-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122723. | |
| Gotistobart | Gotistobart (ONC-392) is a humanized anti-CTLA-4 antibody that confers immunotherapeutic effect by selective depletion of regulatory T cells (Treg) in the tumor microenvironment [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ONC-392; BNT 316. CAS No. 2226344-78-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990042. | |
| Govorestat | Govorestat (AT-007) is an orally active brain-penetrant aldose reductase inhibitor with an IC 50 value of 100 pM. Govorestat has the potential for galactose-1-phosphate uridyl transferase deficiency research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AT-007. CAS No. 2170729-29-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-129586. | |
| gp91 ds-tat | gp91 ds-tat, a biological active peptide, is a NADPH oxidase 2 (Nox2) inhibitor. gp91 ds-tat blocks NADPH oxidase-dependent superoxide production. gp91 ds-tat ameliorates high glucose-induced increase in total ROS, LPOs and iron levels. gp91 ds-tat inhibits homocysteine (Hcy)-induced activation of NLRP3 inflammasomes and restores Hcy-inhibited lysosomal TRPML1 channel activity. gp91 ds-tat improves cerebrovascular and cognitive function in APP/PS1 mice. gp91 ds-tat can be used for the study of Alzheimers disease (AD), glomerular inflammation and cardiovascular disease[1][2][3][4]. Uses: Scientific research. Group: Peptides. CAS No. 329902-61-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5381. | |
| GPCR agonist-2 | GPCR agonist-2 (Compound 5j) is a GPCR GPR109b (HM74) agonist, with a pEC 50 value of 6.51. GPCR agonist-2 can be used for research of lipid disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 291528-35-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-47823. | |
| GPCR modulator-1 | GPCR modulator-1 is a negative allosteric modulator of GLP receptor. GPCR modulator-1 has the potential for type 2 diabetes research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1407592-99-7. Pack Sizes: 1 mg. Product ID: HY-124803. | |
| GPDA | GPDA(Glycylproline p-nitroanilide tosylate) is the substarate of X-Prolyl dipeptidyl-aminopeptidase in the enzyme assay. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: GPN; Glycylproline p-nitroanilide tosylate. CAS No. 65096-46-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16710. | |
| GPNA hydrochloride | GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase ( GGT ). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na + -dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na + -independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 67953-08-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W011391. | |
| GPR132 antagonist 1 | GPR132 antagonist 1 (GPR132-B-160, Compound 25) is a GPR132 antagonist with an EC50 value of 0.075 ?M. GPR132 antagonist 1 has promote insulin secretion activity with an EC50 value of 0.7 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 898211-21-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157189. | |
| GPR139 agonist-2 | GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC 50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2983118-29-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-149651. | |
| GPR183 antagonist-2 | GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2924063-98-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162011. | |
| GPR183-IN-2 | GPR183-IN-2 (compound 23) is a potent GPR183 inhibitor. GPR183-IN-2 inhibits Ca 2+ mobilization with an IC 50 value of 39.45 nM. GPR183-IN-2 has the potential for the research of cancer, autoimmune diseases, pain, and osteoporosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2924064-10-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163796. | |
| GPR34 receptor antagonist 2 | GPR34 receptor antagonist 2 (Compound D2) is a GPR34 receptor antagonist. GPR34 receptor antagonist 2 can be used for immune diseases, inflammatory diseases research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 907952-06-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-138501. | |
| GPR34 receptor antagonist 3 | GPR34 receptor antagonist 3 (Compound 5e) is a class of GRP34 antagonists, IC50 is 0.680??M. GPR34 receptor antagonist 3 inhibited ERK1/2 phosphorylation induced by lysophosphatidylserine in a dose-dependent way without obvious cytotoxicity. GPR34 receptor antagonist 3 shows antisensory activity in mouse neuropathic pain model [1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155417. | |
| GPR35 agonist 5 | GPR35 agonist 5 (3,5-dinitro-bisphenol A; compound 6) is a weak GPR35 agonist. GPR35 agonist 5 arrests CHO-S cells at the G1/Gophase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2226201-24-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149190. | |
| GPR3 agonist-2 | GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC50of 260 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1983120-51-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155318A. | |
| GPR52 antagonist-1 | GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC50 of 0.63 ?M. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1239987-91-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145468. | |
| GPR55 agonist 3 | GPR55 agonist 3 (Compound 26) is a GPR55 agonist ( EC 50 : 0.239 nM, and 1.76 nM for hGPR55 and rGPR55). GPR55 agonist 3 induces β-arrestin recruitment to human GPR55 ( EC 50 : 6.2 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3006105-44-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156107. | |
| GPR81 agonist 1 | GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50s of 58 nM and 50 nM for human and mouse GPR81, respectively. GPR81 agonist 1 inhibits lipolysis in differentiated 3T3-L1 adipocytes. GPR81 agonist 1 suppresses lipolysis in mice without cutaneous flushing. GPR81 agonist 1 displays remarkable selectivity for GPR81 over GPR109a[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620992-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135982. | |
| GPRP | GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2]. Uses: Scientific research. Group: Peptides. Alternative Names: Gly-Pro-Arg-Pro; Pefa 6003. CAS No. 67869-62-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0074. | |
| GPRP acetate | GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3]. Uses: Scientific research. Group: Peptides. Alternative Names: Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate. CAS No. 157009-81-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0074A. | |
| GPX4-IN-3 | GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2761004-85-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141809. | |
| GPX4-IN-4 | GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2920221-53-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149923. | |
| GPX4-IN-5 | GPX4-IN-5 is a covalent inhibitor of GPX4 (IC50: 0.12 ?M). GPX4-IN-5 can induce ferroptosis and has anti-tumor effects. GPX4-IN-5 can be used in the study of triple-negative breast cancer (TNBC)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2922824-09-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-155663. | |
| GQ-16 | GQ-16 is a moderate affinity ligand for the ligand-binding domain (LBD) of PPARγ , exhibiting a K i of 160 nM. GQ-16 is an effective inhibitor of Cdk5-mediated phosphorylation of PPAR&gamma. GQ-16 is a partial agonist of PPARγ with reduced adipogenic actions. GQ-16 promotes insulin Sensitization without weight gain [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 870554-67-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111254. | |
| GR 113808 | GR 113808 is a potent and highly selective 5-HT 4 receptor antagonist ( pK b = 8.8). GR 113808 shows 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 144625-51-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103152. | |
| GR127935 hydrochloride | GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used in neurological disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148642-42-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-100794. | |
| GR24 | (Rac)-GR24 (Strigolactone GR24) is a plant hormone analog. (Rac)-GR24 can mimic the natural germination stimulus of parasitic plant seeds, promoting seed germination in the absence of host plants, thereby reducing the number of parasitic seeds in the soil. (Rac)-GR24 can be used in agricultural research [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Strigolactone GR24. CAS No. 76974-79-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-129038. | |
| GR 55562 hydrochloride | GR 55562 hydrochloride is a selective 5-HT 1B receptor antagonist. GR 55562 hydrochloride can be used for the research of nerve disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 172854-55-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W010869. | |
| GR-73632 | GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist[1]. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals[2]. Uses: Scientific research. Group: Peptides. CAS No. 133156-06-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1192. | |
| GR 89696 | GR 89696 is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 126766-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-107747. | |
| Gracillin | Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy[1][2]. Uses: Scientific research. Group: Natural products. CAS No. 19083-00-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0706. | |
| Gramicidin | Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. Uses: Scientific research. Group: Peptides. CAS No. 1405-97-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-P0163. | |
| Gramicidin A | Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α ( HIF-1α ) [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 11029-61-1. Pack Sizes: 5 mg. Product ID: HY-P2324. | |
| Gramicidin S | Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic. Gramicidin S is active against Gram-negative and Gram-positive bacteria by perturbing integrity of the bacterial membranes. Gramicidin S also inhibits cytochrome bd quinol oxidase [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Gramicidin soviet. CAS No. 113-73-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5712. | |
| Gramine | Gramine (Donaxine) is a natural alkaloid isolated from giant reed [2] , acts as an active adiponectin receptor (AdipoR) agonist, with IC 50 s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively [1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist [2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Donaxine. CAS No. 87-52-5. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-N0166. | |
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