MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Guanadrel | Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 40580-59-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W376701. |  |
| Guancydine | Guancydine (Guancidine) is an antihypertensive agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Guancidine. CAS No. 1113-10-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-101554. | |
| Guanethidine sulfate | Guanethidine sulfate (Guanethidine monosulfate), an antihypertensive agent, is an adrenergic neurone blocking agent. Guanethidine sulfate enters noradrenergic nerve terminals by the neuronal amine carrier [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Guanethidine monosulfate. CAS No. 645-43-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0800. | |
| Guanfacine | Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 29110-47-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17416A. | |
| Guanfacine hydrochloride | Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 29110-48-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17416. | |
| Guanidine hydrochloride | Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Guanidinium chloride; Aminoformamidine hydrochloride. CAS No. 50-01-1. Pack Sizes: 10 mM * 1 mL; 25 g. Product ID: HY-B0178A. | |
| Guanidine thiocyanate | Guanidine thiocyanate is a strong protein denaturant and potent inhibitor of nucleases. Guanidinium thiocyanate is a nucleic acid protector in the extraction of DNA and RNA from cells. Guanidine thiocyanate is a common component of buffers used for nucleic acid extraction [1]. Uses: Scientific research. Group: Natural products. CAS No. 593-84-0. Pack Sizes: 10 mM * 1 mL; 25 g. Product ID: HY-D0841. | |
| Guanidinoethyl sulfonate | Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 ?M). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: Taurocyamine. CAS No. 543-18-0. Pack Sizes: 50 mg; 100 mg. Product ID: HY-113329. | |
| Guanidinosuccinic acid | Guanidinosuccinic acid is a nitrogenous metabolite. Uses: Scientific research. Group: Natural products. CAS No. 6133-30-8. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg. Product ID: HY-113373. | |
| Guanine | Guanine is one of the fundamental components of nucleic acids ( DNA and RNA ). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 73-40-5. Pack Sizes: 100 mg. Product ID: HY-Y1055. | |
| Guanoclor | Guanoclor is an antihypertensive compound. Guanoclor is an adrenergic neurone-blocking agent, which also interferes with noradrenaline synthesis by inhibition of the enzyme dopamine beta-hydroxylase [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Vatensol. CAS No. 5001-32-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100796. | |
| Guanosine | Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti- HSV activity. Uses: Scientific research. Group: Natural products. Alternative Names: DL-Guanosine; Vernine. CAS No. 118-00-3. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-N0097. | |
| Guanosine-13C10 | Guanosine-13C10 is the 13C labeled Guanosine (HY-N0097). Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a ?-N9-glycosidic bond. Guanosine possesses anti-HSV activity[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: DL-Guanosine-13C10; Vernine-13C10. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N0097S4. | |
| Guanosine-13C10,15N5 | Guanosine- 13 C 10 , 15 N 5 is the 13 C and 15 N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity [1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: DL-Guanosine- 13 C10, 15 N5; Vernine- 13 C10, 15 N5. CAS No. 202406-81-3. Pack Sizes: 1 mg. Product ID: HY-N0097S6. | |
| Guanosine 5'-diphosphate disodium salt | Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K + channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)- ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: GDP disodium salt. CAS No. 7415-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-113066A. | |
| Guanosine-5'-triphosphate disodium salt | Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1][2]. Uses: Scientific research. Group: Natural products. Alternative Names: 5'-GTP disodium salt. CAS No. 56001-37-7. Pack Sizes: 250 mg (100 mM * 4.41 mL in Water); 500 mg (100 mM * 8.82 mL in Water); 1 g (100 mM * 17.63 mL in Water). Product ID: HY-W010737. | |
| Guanosine 5'-triphosphate trisodium salt | Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1][2]. Uses: Scientific research. Group: Natural products. Alternative Names: 5'-GTP trisodium salt. CAS No. 36051-31-7. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-12695. | |
| Guanylate cyclase-IN-1 | Guanylate cyclase-IN-1 (Example 46) is a guanylate cyclase inhibitor that can be used for cardiovascular diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1361569-23-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W021162. | |
| Guanylyl imidodiphosphate lithium | Guanylyl imidodiphosphate (Gpp(NH)p) lithium, a non-hydrolyzable GTP analogue, increases adenylate cyclase activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Gpp(NH)p lithium. CAS No. 64564-03-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-137167. | |
| Gue1654 | Gue1654 is a modulator of OXE-R. Gue1654 inhibits Gβγ but not Gα signaling triggered upon activation of Gα(I)-βγ by the chemoattractant receptor OXE-R. Gue1654 does not interfere nonspecifically with signaling directly at or downstream of Gβγ [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 397290-30-1. Pack Sizes: 1 mg. Product ID: HY-110114. | |
| Guggulsterone | Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products ( IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin ), modulation of cell cycle proteins ( cyclin D1 and c-Myc ), activation of caspases and JNK , inhibition of Akt [1]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC 50 s of 17 and 15 μM for Z- and E-Guggulsterone, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Z/E-Guggulsterone. CAS No. 95975-55-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107738. | |
| Guluronic acid sodium | Guluronic acid sodium is an uronic acid monosaccharide and a glucuronic acid diasteroisomer. Guluronic acid sodium is a nonsteroidal anti-inflammatory agent[1]. Uses: Scientific research. Group: Natural products. Alternative Names: G2013 sodium. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N7700A. | |
| Gum arabic | Gum Arabic (Arabic gum) is a branched-chain, complex polysaccharide derive from A. Senegal. Gum Arabic is an anti-oxidant, and can protect against experimental hepatic-, renal- and cardiac toxicities. Gum Arabic also can be used in immunohistochemistry [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Arabic gum. CAS No. 9000-1-5. Pack Sizes: 10 g; 25 g. Product ID: HY-N6664. | |
| Gusacitinib | Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASN-002. CAS No. 1425381-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103018. | |
| Guselkumab | Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with K d values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CNTO 1959. CAS No. 1350289-85-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9931. | |
| Guvacine hydrochloride | Guvacine hydrochloride is an alkaloid from the nut of Areca catechu , acts as an inhibitor of GABA transporter , and dispalys modest selectivity for cloned GABA transporters with IC 50 s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Uses: Scientific research. Group: Natural products. CAS No. 6027-91-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-100809. | |
| Guvacoline hydrochloride | Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra , can act as a weak full agonist of atrial and ileal muscarinic receptors [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 6197-39-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N5016. | |
| GW0742 | GW0742 is a potent PPARβ and PPARδ agonist, with an IC 50 of 1 nM for human PPARδ in binding assay, and EC 50 s of 1 nM, 1.1 μM and 2 μM for human PPARδ , PPARα, and PPARγ, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW610742. CAS No. 317318-84-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13928. | |
| GW-1100 | GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9. Uses: Scientific research. Group: Signaling pathways. CAS No. 306974-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-50691. | |
| GW1929 | GW 1929 is an orally active peroxisome proliferator-activated receptor-? (PPAR?) agonist with a pKi of 8.84 for human PPAR-?, and pEC50s of 8.56 and 8.27 for human PPAR-? and murine PPAR-?, respectively. GW 1929 (hydrochloride) has antidiabetic efficacy and neuroprotective potential[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 196808-24-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15655. | |
| GW2580 | GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 ?M. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 870483-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-10917. | |
| GW274150 | GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) ( IC 50 =2.19 μM; K d =40 nM) and rat iNOS ( ED 50 =1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS ( eNOS ) and neuronal NOS ( nNOS ). GW274150 exerts a protective role in an acute model of lung injury inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 210354-22-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119. | |
| GW274150 phosphate | GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) ( IC 50 =2.19 μM; K d =40 nM) and rat iNOS ( ED 50 =1.15 μM). GW274150 phosphate displays less potency for both humans or rats endothelial NOS ( eNOS ) and neuronal NOS ( nNOS ). GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 438542-15-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119A. | |
| GW280264X | GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 866924-39-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115670. | |
| GW3965 hydrochloride | GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC 50 s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 405911-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10627A. | |
| GW-405833 | GW-405833 (L768242) is a potent, selective cannabinoid receptor 2 (CB 2 ) agonist with an EC 50 of 50.7 nM. GW-405833 also behaves as a noncompetitive CB 1 antagonist. GW-405833 suppresses inflammatory and neuropathic pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L768242. CAS No. 180002-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110036. | |
| GW405833 hydrochloride | GW-405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB 2 ) agonist with an EC 50 of 50.7 nM. GW-405833 hydrochloride also behaves as a noncompetitive CB 1 antagonist. GW-405833 hydrochloride suppresses inflammatory and neuropathic pain [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L768242 hydrochloride. CAS No. 1202865-22-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110036A. | |
| GW 4064 | GW 4064 is a potent FXR agonist with an EC50 of 65 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 278779-30-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50108. | |
| GW 441756 | GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 504433-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18314. | |
| GW4869 | GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC 50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6823-69-4. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19363. | |
| GW 501516 | GW 501516 (GW 1516) is a PPARδ agonist with an EC 50 of 1.1 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW 1516; GSK-516. CAS No. 317318-70-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10838. | |
| GW 5074 | GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220904-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10542. | |
| GW627368 | GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 439288-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16963. | |
| GW6471 | GW6471 is a potent PPAR? antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 880635-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15372. | |
| GW7647 | GW7647 is a potent PPAR? agonist, with EC50s of 6 nM, 1.1 ?M, and 6.2 ?M for human PPAR?, PPAR? and PPAR?, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 265129-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13861. | |
| GW779439X | GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of ?-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway[1][2]. MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus. Uses: Scientific research. Group: Signaling pathways. CAS No. 551919-98-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103645. | |
| GW788388 | GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-? type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor. Uses: Scientific research. Group: Signaling pathways. CAS No. 452342-67-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10326. | |
| GW791343 dihydrochloride | GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC 50 of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1019779-04-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15469. | |
| GW806742X | GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 ?M. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 579515-63-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112292. | |
| GW 833972A | GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092502-33-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101765. | |
| GW843682X | GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, with IC50s of 2.2 nM and 9.1 nM, respectively, and is also >100-fold selective against ?30 other kinases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW843682. CAS No. 660868-91-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-11003. | |
| GW9508 | GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 885101-89-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15589. | |
| GW9662 | GW9662 is a potent and selective PPAR? antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPAR? and PPAR?, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 22978-25-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16578. | |
| GYKI 52466 dihydrochloride | GYKI 52466 dihydrochloride is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC 50 values of 7.5 and 11μM, respectively. GYKI 52466 dihydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 dihydrochloride can be used in Parkinson's disease research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2319722-40-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103234A. | |
| GYKI 53655 hydrochloride | GYKI 53655 (LY300168) hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ( AMPA ) antagonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY300168 hydrochloride. CAS No. 143692-48-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103228. | |
| Gymnemic acid I | Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I decreases the apoptosis under the high glucose stress [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 122168-40-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2541. | |
| Gynostemma Extract | Gynostemma Extract (Ginsenoside C-Mx1) is a natural product. Uses: Scientific research. Group: Natural products. Alternative Names: Ginsenoside C-Mx1; Gypenoside IX. CAS No. 80321-63-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0167. | |
| GYY4137 | GY4137 is a sustained-release H2S donor possessing vasodilatory, antihypertensive, and anti-inflammatory activities. GY4137 can inhibit cell growth, induce apoptosis, and cause cell cycle arrest by blocking the STAT3 pathway, demonstrating potent anticancer activity[1][2][3][4][5][6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 106740-09-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107632. | |
| H-1152 dihydrochloride | H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. Uses: Scientific research. Group: Signaling pathways. CAS No. 871543-07-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15720A. | |
| H-151 | H-151 is a potent, selective and covalent antagonist of STING that has noteworthy inhibitory activity both in cells and in vivo. H-151 reduces TBK1 phosphorylation and suppresses STING palmitoylation. H-151 can be used for the research of autoinflammatory disease[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 941987-60-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112693. | |
| H2DCFDA | H2DCFDA (DCFH-DA) is a cell-permeable probe used to detect intracellular reactive oxygen species (ROS) (Ex/Em=488/525 nm) [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate. CAS No. 4091-99-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D0940. | |
| H2L 5765834 | H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA1, LPA3, and LPA5, with IC50s of 94, 752, and 463 nM respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 420841-84-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15706. | |
| H2N-PEG2-CH2COOtBu | H2N-PEG2-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1122484-77-8. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-135927. | |
| H3B-6527 | H3B-6527 is an orally active, highly selective and covalent FGFR4 inhibitor with an IC 50 of <1.2 nM. H3B-6527 has at least 250-fold selectivity over FGFR1-3 with IC 50 s of 320 nM, 1290 nM and 1060 nM respectively. H3B-6527 has potent anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1702259-66-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100491. | |
| H3B-6545 | H3B-6545 is an oral, selective estrogen receptor covalent antagonist ( SERCA ) for the research of metastatic ER-positive, HER2-negative breast cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2052130-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112596. | |
| H3B-6545 hydrochloride | H3B-6545 hydrochloride is an oral, selective estrogen receptor covalent antagonist ( SERCA ) for the research of metastatic ER-positive, HER2-negative breast cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2052132-51-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112596A. | |
| H3B-8800 | H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1825302-42-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111517. | |
| H4 Receptor antagonist 1 | H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC 50 of 19 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 848217-00-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114025. | |
| H-89 | H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases. Uses: Scientific research. Group: Signaling pathways. CAS No. 127243-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15979. | |
| H-89 dihydrochloride | H-89 dihydrochloride is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase. Uses: Scientific research. Group: Signaling pathways. CAS No. 130964-39-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15979A. | |
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