MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| JMJD1C-IN-1 | JMJD1C-IN-1 (compound 193D7) is an inhibitor of JMJD1C with oral activity. JMJD1C-IN-1 targets tumor Treg cells without affecting systemic immune homeostasis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 861224-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162275. |  |
| JMS-17-2 | JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC 50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1380392-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-123918. | |
| JMV 449 acetate | JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC 50 of 0.15 nM for inhibition of 125 I-neurotensin binding to neonatal mouse brain and an EC 50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 141863-45-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1256C. | |
| JNJ0966 | JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 315705-75-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103482. | |
| JNJ-1013 | JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKB?, pSTAT3(Tyr705) (Pink: ligand for target protein (HY-138834); black: linker (HY-Y1760); Blue: E3 ligase ligand (HY-112078))[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2597343-08-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153188. | |
| JNJ-10198409 | JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor ( IC 50 =2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase ( IC 50 =4.2 nM) and PDGFR-α kinase ( IC 50 =45 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 627518-40-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-W011266. | |
| JNJ-10397049 | JNJ-10397049 is a potent and selective orexin 2 receptor (OX 2 R) antagonist, with a pK i of 8.3. JNJ-10397049 is 600-fold selective for the OX 2 R over the OX 1 R [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 708275-58-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10896. | |
| JNJ16259685 | JNJ16259685 is a selective antagonist of mGlu1 receptor , and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC 50 of 19 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 409345-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100407. | |
| JNJ-17203212 | JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 821768-06-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100129. | |
| JNJ-18038683 | JNJ-18038683 is a 5-Hydroxytryptamine Type 7 ( 5-HT 7 ) receptor antagonist, with pK i s of 8.19, 8.20 for rat and human 5-HT 7 in HEK293 cells, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 851376-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19889. | |
| JNJ-28583113 | JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3? and ? subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2765255-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-149143. | |
| JNJ-37822681 dihydrochloride | JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D 2 receptor antagonist with a moderate binding affinity for the dopamine D 2L receptor ( K i =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2108806-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111066A. | |
| JNJ-38877605 | JNJ-38877605 is an orally active ATP-competitive inhibitor of c-Met with an IC 50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases [1] [2]. JNJ-38877605 inhibits c-Met phosphorylation and regulates lipid accumulation. JNJ-38877605 can be used for tumor and metabolic disease reseach [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 943540-75-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50683. | |
| JNJ-40418677 | JNJ-40418677 is an orally active modulator of γ-secretase , can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease , with IC 50 s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimers disease research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1146594-87-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100604. | |
| JNJ-41443532 | JNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity ( IC 50 =37 nM) and potent functional antagonism ( chemotaxis IC 50 =30 nM). JNJ-41443532 displays a K i of 9.6 μM for mCCR2 binding. JNJ-41443532 can be used in the research of inflammatory disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCR2 antagonist 5. CAS No. 1228650-83-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13499. | |
| JNJ-42041935 | JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase PHD ; inhibits PHD1, PHD2, and PHD3 with pK i values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1193383-09-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12832. | |
| JNJ-42165279 | JNJ-42165279 is an orally active FAAH inhibitor, with IC 50 values of 70 nM for hFAAH and 313 nM for rFAAH. JNJ-42165279 can be used in research related to the field of neuropathic pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346528-50-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19636. | |
| JNJ-47965567 | JNJ-47965567 is a centrally permeable, high-affinity, selective P2X7 antagonist, with pKis of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1428327-31-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101418. | |
| JNJ-49095397 | JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the ? and ? isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RV568. CAS No. 1220626-82-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120595. | |
| JNJ-5207852 | JNJ-5207852 is a selective and potent histamine H 3 receptor (H 3 R) antagonist, with pK i s of 8.9, 9.24 for rat and human H 3 R, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 398473-34-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12190. | |
| JNJ-55308942 | JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1? release from adult rodent brain[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2166558-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123857. | |
| JNJ-63576253 | JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR) , with IC 50 s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TRC-253. CAS No. 2110428-64-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115282A. | |
| JNJ-64264681 | JNJ-64264681 is a potent, orally active, selective and irreversible covalent BTK inhibitor. JNJ-64264681 exhibits good pharmacokinetic characteristics and can be used for cancer and autoimmune diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2101524-34-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153245. | |
| JNJ-7706621 | JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC50s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A and aurora-B, respectively[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 443797-96-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10329. | |
| JNJ-7777120 | JNJ-7777120 is a potent and selective histamine H 4 receptor antagonist ( K i =4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 459168-41-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13508. | |
| (-)-JNJ-A07 | (-)-JNJ-A07 is a potent and selective DENV inhibitor with an EC 50 value of 31 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2135640-92-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139602C. | |
| (+)-JNJ-A07 | (+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2135640-93-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139602. | |
| JNJ-DGAT2-A | JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 ?M in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1962931-71-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110381. | |
| JNK-IN-7 | JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNK inhibitor. CAS No. 1408064-71-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15617. | |
| JNK-IN-8 | JNK-IN-8 (JNK Inhibitor XVI) is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNK Inhibitor XVI. CAS No. 1410880-22-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13319. | |
| JNK Inhibitor VIII | JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TCS JNK 6o. CAS No. 894804-07-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-107598. | |
| JNU-0921 | JNU-0921 is a potent and orally active CD137 agonist. JNU-0921 increases the mRNA expression of IFN-? and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8+ T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161982. | |
| ?JOE | JOE is a fluorescent dye and can be used as a fluorescent label in DNA sequencing, PCR, and LCR amplifications. JOE possesses an absorbance of 525 nm and an emission of 550 nm [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 82855-40-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D1090. | |
| Josamycin | Josamycin (EN-141) is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant K d from ribosome for Josamycin is 5.5 nM [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: EN-141. CAS No. 16846-24-5. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B1920. | |
| JP83 | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC 50 of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 887264-44-0. Pack Sizes: 1 mg. Product ID: HY-111199. | |
| (+)-JQ-1 | (+)-JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2))[1]. (+)-JQ-1 also activates autophagy[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JQ1. CAS No. 1268524-70-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13030. | |
| JQ-1 (carboxylic acid) | JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4. Uses: Scientific research. Group: Signaling pathways. CAS No. 202592-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-78695. | |
| (+)-JQ1 PA | (+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2115701-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112789. | |
| JR14a | JR14a is a potent thiophene antagonist of human complement C3a receptor. JR14a shows selectivity for the human C3a receptor over C5a receptor. JR14a can suppress C3aR-mediated inflammation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411440-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138161. | |
| JR-AB2-011 | JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 ?M. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 ?M)[1].JR-AB2-011 decreases the phosphorylation level of Akt, decreases MMP2 activity, thereby reducing the ability of tumor cells to migrate and invade. JR-AB2-011 also induces non-apoptotic cell death[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411853-34-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122022. | |
| JS11 | JS11 is an inhibitor for natriuretic polypeptide receptor 1 ( Npr1 ) with an IC 50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394592-04-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153650. | |
| JS25 | JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC 50 value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitts lymphoma. JS25 effectively crosses the blood-brain barrier [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411771-95-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151808. | |
| JS6 | JS6 is a Bcl3 inhibitor, and inhibits Bcl3-NF-kB1 binding. JS6 inhibits tumor cell growth in vitro and in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 950244-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152177. | |
| JSH-23 | JSH-23 is an NF-?B inhibitor which inhibits NF-?B transcriptional activity with an IC50 of 7.1 ?M in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-?B p65 without affecting I?B? degradation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 749886-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-13982. | |
| JT001 sodium | JT001 (NLRP3-IN-19) sodium is a potent, specific and orally active inhibitor of NLRP3. JT001 sodium can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 sodium can be used for the research of nonalcoholic steatohepatitis and liver fibrosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NLRP3-IN-19 sodium. CAS No. 2238820-09-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156034A. | |
| JT002 | JT002 is an orally active and selective NLRP3 inflammasome assembly inhibitor. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1?, IL-1?, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice. JT002 can be used for the study of a variety of inflammatory diseases, such as Muckle-Wells syndrome (MWS)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2238820-43-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149478. | |
| JT010 | JT010 is a covalent and site-selective TRPA1 agonist. JT010 can be used in myocardial infarction research[1][2][3][4][5][6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 917562-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111132. | |
| JTC-801 | JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a K i value of 8.2?nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 244218-51-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13274. | |
| JTE-013 | JTE-013 is a potent and specific S1P 2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P 2 with IC 50 s of 17 nM and 22 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 383150-41-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-100675. | |
| JTE-607 | JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-?, IL-1?, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 188791-09-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110133. | |
| JTE-907 | JTE-907 is a highly selective, orally active CB2 receptor inverse agonist and exerts anti-inflammatory effects in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 282089-49-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-103325. | |
| JTV-519 hemifumarate | JTV-519 hemifumarate (K201 hemifumarate) is a Ca 2+ -dependent blocker of sarcoplasmic reticulum Ca 2+ -stimulated ATPase ( SERCA ) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: K201 hemifumarate. CAS No. 1435938-25-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15293B. | |
| Juglone | Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 5-Hydroxy-1,4-naphthalenedione. CAS No. 481-39-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N6949. | |
| JW480 | JW480 is a potent and selective inhibitor of a serine hydrolase enzyme KIAA1363[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1354359-53-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107582. | |
| JW 55 | JW 55 is a potent and selective ?-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW 55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 ?M and 830 nM respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 664993-53-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13968. | |
| JWG-071 | JWG-071 is the kinase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC50 values of 88nM and 109 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2250323-50-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108886. | |
| JX06 | JX06 is a potent, selective and covalent inhibitor of PDK. JX06 inhibits PDK1, PDK2 and PDK3 with IC50s of 49 nM, 101 nM, and 313 nM, respectively. JX06 inhibits PDK1 activity via covalently binding to a cysteine residue in an irreversible manner. JX06 shows significant antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 729-46-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19564. | |
| JY-2 | JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC50 of 22 ?M. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 339103-05-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153347. | |
| JZL 184 | JZL 184 is a potent, selective and irreversible MAGL inhibitor that blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes (IC50 of 8 nM). JZL 184 displays >300-fold selectivity for MAGL over FAAH[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1101854-58-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-15249. | |
| JZL195 | JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC 50 s of 2 and 4 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1210004-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15250. | |
| K02288 | K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431985-92-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12278. | |
| K114 | K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC 50 of 20-30 nM [1]. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI) [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 872201-12-2. Pack Sizes: 2 mg; 5 mg. Product ID: HY-103470. | |
| K145 hydrochloride | K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC 50 of 4.3 μM and a K i of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1449240-68-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15779A. | |
| K-252a | K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively[1][2]. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene[3]. Uses: Scientific research. Group: Natural products. Alternative Names: SF2370; Antibiotic K 252a; Antibiotic SF 2370. CAS No. 99533-80-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N6732. | |
| K284-6111 | K284-6111 is a high-affinity and orally active CHI3L1 inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-?B pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of I?B. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins (eg: iNOS, COX-2, GFAP, and Iba-1). K284-6111 reduces atopic-like skin inflammation and inhibits LPS (HY-D1056) -induced liver injury. K284-6111 can be used for the study of Alzheimer's diseases and sepsis like hepatic injury[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 702668-62-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148013. | |
| K-604 dihydrochloride | K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 ( ACAT-1 ) inhibitor with an IC 50 of 0.45±0.06 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 217094-32-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100400A. | |
| K67 | K67 is a selective the interaction between Keap1 and S349 phosphorylated p62 inhibitor, with an IC50 of 1.5 ?M. K67 has a weaker inhibitory effect on the interaction between Keap1 and Nrf2 (IC50 is 6.2 ?M). K67 competitively binds to the binding site of Keap1 with p-p62, blocking the abnormal activation of the p62-dependent Nrf2 pathway. K67 inhibits tumor cell proliferation and enhances the sensitivity of hepatocellular carcinoma (HCC) to chemotherapeutic drugs by restoring Keap1-mediated ubiquitination and degradation of Nrf2[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2046250-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111126. | |
| K-7174 | K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 191089-59-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12743. | |
| K-7174 dihydrochloride | K-7174 dihydrochloride is an orally active proteasome and GATA inhibitor. K-7174 dihydrochloride is a cell adhesion inhibitor. K-7174 dihydrochloride induces cell apoptosis. K-7174 dihydrochloride shows antitumor activities, it can be used for the research of cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 191089-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12743A. | |
| K777 | K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi , and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC 50 values of 0.68 nM and 0.87 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 233277-99-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119293. | |
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