MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| KU-0060648 | KU-0060648 is a dual inhibitor of PI3K and DNA-PK with IC 50 s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 881375-00-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13431. |  |
| KU-0063794 | KU-0063794 is a potent and specific mTOR inhibitor, inhibiting both the mTORC1 and mTORC2 complexes with IC 50 s of 10 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 938440-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50710. | |
| KU-55933 | KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. Uses: Scientific research. Group: Signaling pathways. CAS No. 587871-26-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12016. | |
| KU-57788 | KU-57788 (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. KU-57788 is an NHEJ pathway inhibitor. KU-57788 also inhibits PI3K and mTOR with IC50s of 5.0 and 1.7 ?M, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NU7441. CAS No. 503468-95-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-11006. | |
| KU-60019 | KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 925701-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12061. | |
| Kurarinone | Kurarinone is an orally active flavonoid isolated from matrine that inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting cell differentiation of Th1 and Th17. Kurarinone has antitumor and anti-inflammatory activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 34981-26-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2279. | |
| Kuromanin chloride | Kuromanin chloride (Chrysontemin) is derived from mulberry leaves and has the effect of increasing blood sugar concentration and maintaining lipid metabolism balance to reduce obesity. Kuromanin chloride can inhibit CD38 enzymatic activities[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: Chrysontemin; Cyanidin 3-O-glucoside chloride. CAS No. 7084-24-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N0640. | |
| KUS121 | KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1357164-52-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-138233. | |
| Kuwanon K | Kuwanon K is a natural product that can be isolated from Morus Lhou [1]. Uses: Scientific research. Group: Natural products. CAS No. 88524-66-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N11463. | |
| Kv2.1-IN-1 | Kv2.1-IN-1 (compound 80) is a potent inhibitor of Kv2.1, with the IC 50 value of 0.07 μM, selectivity >130 fold over other K + , Na + , and Ca 2+ ion channels [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2252448-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161104. | |
| KVS0001 | KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3056394-59-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161111. | |
| KW-2449 | KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively.. Uses: Scientific research. Group: Signaling pathways. CAS No. 1000669-72-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10339. | |
| KW-2478 | KW-2478 is an inhibitor of Hsp90α , with an IC 50 of 3.8 nM, and has antitumor activity against various human hematological tumor cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 819812-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13468. | |
| KW-8232 | KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 217813-15-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100304A. | |
| KW-8232 free base | KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 170365-25-0. Pack Sizes: 1 mg. Product ID: HY-100304. | |
| KWAR 23 | KWAR23 is an anti-human SIRP? antibody. KWAR23 binds human SIRP? with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research[1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2243227-60-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99175. | |
| KY02111 | KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1118807-13-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13815. | |
| KY-05009 | KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-?1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228280-29-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124745. | |
| Kynuramine dihydrochloride | Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 36681-58-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-119395B. | |
| Kynurenic acid | Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. Uses: Scientific research. Group: Natural products. Alternative Names: Quinurenic acid. CAS No. 492-27-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-100806. | |
| Kynurenic acid-d5 | Kynurenic acid-d5 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, ?7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Quinurenic acid-d5. CAS No. 350820-13-2. Pack Sizes: 5 mg. Product ID: HY-100806S. | |
| Kynurenic acid sodium | Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. Uses: Scientific research. Group: Natural products. CAS No. 2439-2-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-107512. | |
| Kyotorphin | Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer's Disease patients [1]. Uses: Scientific research. Group: Peptides. CAS No. 70904-56-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-122381. | |
| KYP-2047 | KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 796874-99-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100475. | |
| KZR-504 | KZR-504 is a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 ?M for LMP2 and LMP7, respectively. KZR-504 is of interest for the treatment of autoimmune disease[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629052-78-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101786. | |
| L 012 sodium salt | L 012 sodium salt is a luminal-based chemiluminescent probe. L 012 sodium salt can detect NADPH oxidase (Nox)-derived superoxide and nitrogen species (reactive oxygen species (ROS) and reactive nitrogen species (RNS))[1][2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 143556-24-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108537. | |
| L 152804 | L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a K i of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6508-43-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107734. | |
| L-161982 | L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 147776-06-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108559. | |
| L-165041 | L-165041 is a cell permeable PPAR? agonist, with Kis of 6 nM and appr 730 nM for PPAR? and PPAR?, respectively, and induces adipocyte differentiation in NIH-PPAR? cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 79558-09-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-20019. | |
| L17E | L17E, an endosomolytic peptide, is a cationic amphiphilic peptide with specific membrane lytic activity for late endosomes (LEs). L17E diminishes the TS5-p45 induced apoptosis in a dose-dependent manner. L17E is endocytosed into cells and trafficked to LEs. Within the acidic environment of LEs, L17E perturbs and lyses the LE membrane, leading to disruption of LE membrane and release of LE content to the cytosol. L17E is used to investigate the role of the endosomal protein trafficking pathway[1]. Uses: Scientific research. Group: Peptides. CAS No. 1898254-09-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4121. | |
| L-2-Hydroxyglutaric acid | L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation [1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase ( Mi-CK ) activity with K m and K i of 2.52 mM and 11.13 mM, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-2-Hydroxyglutaric acid. CAS No. 13095-48-2. Pack Sizes: 5 mg (67.52 mM * 0.5 mL in Ethanol); 10 mg (67.52 mM * 1 mL in Ethanol). Product ID: HY-113039. | |
| L-2-Hydroxyglutaric acid disodium | L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation [1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase ( Mi-CK ) activity with K m and K i of 2.52 mM and 11.13 mM, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-2-Hydroxyglutaric acid disodium. CAS No. 63512-50-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W015114. | |
| L-2-Phosphoglyceric acid sodium hydrate | L-2-Phosphoglyceric acid sodium hydrate is an endogenous metabolite[1]. Uses: Scientific research. Group: Natural products. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128736C. | |
| L319 | L319 is an ionizable cationic lipidoid and can be used for synthetic liposomes, from the patent WO-2011153493-A2, compound 1 [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Di((Z)-Non-2-en-1-yl) 9- ( (4- (dimethylamino) butanoyl) oxy) heptadecanedioate. CAS No. 1351586-50-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139298. | |
| L-364,373 | L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R-L3. CAS No. 103342-82-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108591. | |
| L-368,899 hydrochloride | L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC 50 s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. L-368,899 hydrochloride used as a tocolytic agent [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 160312-62-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108677. | |
| L-371,257 | L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor ( K i =19 nM) and vasopressin V1a receptor ( K i =3.7 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 162042-44-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15010. | |
| L-5-Hydroxytryptophan | L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist [1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: L-5-HTP; Oxitriptan. CAS No. 4350-9-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1716. | |
| L-5-Hydroxytryptophan (Standard) | L-5-Hydroxytryptophan (Standard) is the analytical standard of L-5-Hydroxytryptophan. This product is intended for research and analytical applications. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist [1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: L-5-HTP (Standard); Oxitriptan (Standard). CAS No. 4350-9-8. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1716R. | |
| L-655708 | L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist ( K i =0.45 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 130477-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14426. | |
| L67 | L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC 50 are 10 μM). L67 can cause nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS. L67 also activates the Caspase 1 -dependent apoptosis pathway in cancer cells, can be used in cancer research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DNA Ligase Inhibitor. CAS No. 325970-71-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15586. | |
| L-685458 | L-685458 is a potent transition state analog (TSA) ?-secretase inhibitor (GSI). L-685458 inhibits amyloid ?-protein precursor ?-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits ?-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimers disease (AD) and cancers[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-685,458. CAS No. 292632-98-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19369. | |
| L-733060 hydrochloride | L-733060 hydrochloride is a potent tachykinin NK 1 receptor antagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148687-76-7. Pack Sizes: 1 mg. Product ID: HY-14406A. | |
| L-741626 | L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 81226-60-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101348. | |
| L-742001 hydrochloride | L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC 90 of 4.3 μM for vRNP activity in HEK293T cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 174605-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-118368. | |
| L-745870 | L-745870 is a potent, selective, brain-penetrant and orally active dopamine D 4 receptor antagonist with a K i of 0.43 nM. L-745870 shows weaker affinity for D 2 ( K i of 960 nM) and D 3 ( K i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT 2 receptors, sigma sites and α-adrenoceptors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 158985-00-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14325. | |
| L-745870 hydrochloride | L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D 4 receptor antagonist with a K i of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D 2 ( K i of 960 nM) and D 3 ( K i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT 2 receptors, sigma sites and α-adrenoceptors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1173023-36-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14325B. | |
| L748337 | L748337 is a potent ?3-adrenergic receptor antagonist and displays selectivity over ?1 and ?2 receptors. The Ki values of L748337 for ?3-, ?2- and ?1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively[1]. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6[2]. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 244192-94-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103211. | |
| L755507 | L755507 is a potent, selective agonist of ?3-AR with an IC50 of 35 nM. L755507 enhances the homology-directed repair (HDR)-mediated genome editing[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 159182-43-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-19334. | |
| L-778123 | L-778123 is a dual FPTase and GGPTase-I inhibitor, with IC 50 s of 2 nM and 98 nM respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183499-57-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16273. | |
| L-778123 hydrochloride | L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I , with IC 50 values of 2 nM and 98 nM respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 253863-00-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16273A. | |
| L-798106 | L-798106 is potent and highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM), it also has ?micromolar activities at the EP4, EP1 and EP2 receptors with Ki values of 916 nM, >5000 nM and >5000 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CM9; GW671021. CAS No. 244101-02-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15274. | |
| L82 | L82 is a selective and uncompetitive DNA ligase 1 ( DNA Lig1 ) inhibitor (hLig1 IC 50 =12 μM). L82 shows anti-proliferative activity to breast cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 329227-30-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15587. | |
| L82-G17 | L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 92285-87-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148161. | |
| L-902688 | L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 634193-54-7. Pack Sizes: 1 mg (11.92 mM * 200 ?L in Methanol). Product ID: HY-119163. | |
| Labetalol | Labetalol (AH5158) is an orally active selective α1- and non-selective β-adrenergic receptors competitive antagonist. Labetalol, an anti-hypertensive agent, can be used for the research of cardiovascular disease, such as hypertension in pregnancy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AH5158; Sch-15719W free base. CAS No. 36894-69-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121383. | |
| Labetalol hydrochloride | Labetalol hydrochloride is a mixed alpha/beta adrenergic antagonist that is used to treat high blood pressure. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AH-5158 hydrochloride; Sch-15719W. CAS No. 32780-64-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B1108. | |
| Labetalol (hydrochloride) (Standard) | Labetalol (hydrochloride) (Standard) is the analytical standard of Labetalol (hydrochloride). This product is intended for research and analytical applications. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AH-5158 hydrochloride(Standard); Sch-15719W (Standard). CAS No. 32780-64-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1108R. | |
| Labetuzumab | Labetuzumab is a humanised anti-carcinoembryonic antigen (CEA) monoclonal antibody that inhibits tumour growth and sensitises human medullary thyroid cancer xenografts to Dacarbazine chemotherapy[1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 219649-07-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99160. | |
| Labetuzumab govitecan | Labetuzumab govitecan (IMMU 130) is an Anti- CEACAM5 / SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IMMU 130; hMN-14-SN-38. CAS No. 1469876-18-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99681. | |
| L-(+)-Abrine | L-(+)-Abrine, a lethal albumin found in Abrus precatorius seeds, is an acute toxic alkaloid and chemical marker for abrin. Uses: Scientific research. Group: Natural products. Alternative Names: L-Abrine; L-N-Methyltryptophan; N-α-Methyl-L-tryptophan. CAS No. 526-31-8. Pack Sizes: 50 mg; 100 mg. Product ID: HY-N1436. | |
| Laccase, Microorganisms | Laccase, Microorganisms (Denilite IIS) is a multi-copper oxidase (MCOs), which widely exists in microorganisms, plants and fungi, and can catalyze the oxidation of one electron of various phenolic compounds. Laccase can promote the oxidative coupling of single lignin, which plays an important role in the formation and biodegradation of lignin, and also has the potential to cross-link food polymers [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Denilite IIS. CAS No. 80498-15-3. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-P2890. | |
| Lacidipine | Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 103890-78-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-B0347. | |
| LacK free acid | LacK (free acid) is a lysine derivative used in lactate acylation studies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1227379-69-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W883690. | |
| Lacnotuzumab | Lacnotuzumab (MCS110) is a neutralizing humanized IgG1/κ monoclonal antibody targeting CSF-1 that prevents CSF-1 from activating the CSF-1R. Lacnotuzumab can be used for the research of pigmented villonodular synovitis [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MCS110. CAS No. 1831128-32-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99368. | |
| Lactacystin | Lactacystin is a potent, orally active, irreversible, cell-permeable, selective 20S proteasome inhibitor (IC50 = 4.8 ?M). Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces apoptosisand cell cycle arrest, and has antiviral and antioxidative activity. Lactacystin induces neurite outgrowth and hypertension. Lactacystin has the potential for the research of cancer, Neurological Disease, hypertension and Malaria, and so on[1][2] [3][4][5][6] [7][8][9][10]. Uses: Scientific research. Group: Natural products. CAS No. 133343-34-7. Pack Sizes: 50 ?g; 100 ?g; 500 ?g. Product ID: HY-16594. | |
| Lactate | Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Lactic acid. CAS No. 50-21-5. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B2227. | |
| Lactate calcium | Lactate (Lactic acid) calcium is used by the beverage industry as a source of calcium to fortify fruit juice. Lactate calcium facilitates the growth and phytic acid degradation of soybean sprouts [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Lactic acid calcium. CAS No. 814-80-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B2227A. | |
| Lactate-d3 (sodium) (60% in water) | Lactate-d 3 sodium (60% in water) is the deuterium labeled Lactate sodium (60% in water). Lactate sodium (60% in water) is the product of glycogenolysis and glycolysis. Lactate sodium (60% in water) functions in a variety of biochemical processes [1] [2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Lactic acid-d3 sodium. CAS No. 1219802-24-0. Pack Sizes: 1 mg (5.20 M * 1.67 μL in Water); 5 mg (5.20 M * 8.36 μL in Water); 10 mg (5.20 M * 16.71 μL in Water). Product ID: HY-B2227BS1. | |
| Lactate Dehydrogenase (LDH), Bovine Heart | Lactate Dehydrogenase (LDH), Bovine Heart (LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase) is a biological material or organic compound that can be used in life science research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase. CAS No. 9001-60-9. Pack Sizes: 1 KU. Product ID: HY-P2807F. | |
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