MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| KH7 | KH7 is a soluble adenylyl cyclase (sAC) -specific inhibitor, with IC 50 s of 3-10 μM toward both recombinant purified human sAC t protein and heterologously expressed sACt in cellular assays [1]. KH7 is also a cAMP inhibitor [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 330676-02-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103194. |  |
| KH-CB19 | KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6??M)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1354037-26-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12828. | |
| Khellin | Khellin is a furochromone that can be isolated from Ammi visnuga L. Khellin is an EGFR inhibitor with an IC 50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 82-02-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1394. | |
| KHS101 hydrochloride | KHS101 hydrochloride could selectively induce a neuronal differentiation phenotype and interacts with transforming acidic coiled-coil-containing protein 3 (TACC3). Uses: Scientific research. Group: Signaling pathways. CAS No. 1784282-12-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10996A. | |
| Ki16425 | Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with K i s of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA -induced activation of p42/p44 MAPK [1] [2]. Ki16425 can also inhibit LPA -induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Debio 0719. CAS No. 355025-24-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13285. | |
| KI696 | KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1799974-70-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101140. | |
| KI-7 | KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC 50 =445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC 50 s of 2390 nM and 2550 nM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1489263-00-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-131032. | |
| Ki8751 | Ki8751 is a potent VEGFR2 inhibitor with an IC 50 of 0.9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 228559-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12038. | |
| KIF18A-IN-1 | KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2600559-12-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145034. | |
| KIF18A-IN-6 | KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor with an IC50 of 0.016 ?M against KIF18A microtubule-dependent ATPase activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2914879-10-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-153065. | |
| Kifunensine | Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: FR-900494. CAS No. 109944-15-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19332. | |
| KIN-8194 | KIN-8194 is an orally active dual inhibitor of HCK and BTK, with IC50 values of 0.915 and <0.495 nM, respectively. KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma (MCL). KIN-8194 overcomes ibrutinib (HY-10997) resistance with a survival benefit in TMD-8 ABC DLBCL xenografted mice[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 330786-01-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15805. | |
| Kinesore | Kinesore is an inhibitor of the KLC2-SKIP Interaction. Uses: Scientific research. Group: Signaling pathways. CAS No. 363571-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-112777. | |
| Kinetin | Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Furfuryladenine; N6-Furfuryladenine. CAS No. 525-79-1. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g. Product ID: HY-N0160. | |
| Kinetin riboside | Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 ?M. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N6-Furfuryladenosine. CAS No. 4338-47-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-101055. | |
| KIRA6 | KIRA6 is an advanced small-molecule IRE1? RNase kinase inhibitor with an IC50 of 0.6 μM[2]. KIRA6 can trigger an apoptotic response[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1589527-65-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19708. | |
| KIRA-7 | KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase ( IC 50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1937235-76-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124646. | |
| Kira8 | Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC 50 of 5.9 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMG-18. CAS No. 1630086-20-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114368. | |
| Kirenol | Kirenol is isolated from Siegesbeckia orientalis with anti-inflammatory and analgesic activity[1]. Uses: Scientific research. Group: Natural products. CAS No. 52659-56-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg; 50 mg. Product ID: HY-N0559. | |
| Kisspeptin-10, human | Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression [1]. Uses: Scientific research. Group: Peptides. CAS No. 374675-21-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0254. | |
| Kisspeptin 234 TFA | Kisspeptin 234 TFA, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 TFA is an analog of Kisspeptin 10 [1]. Uses: Scientific research. Group: Peptides. CAS No. 1848962-29-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1196A. | |
| Kisspeptin-54(human) | Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and human GPR54 receptors with K i values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Peptides. Alternative Names: Metastin(human). CAS No. 374683-24-6. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-P1022. | |
| KJ Pyr 9 | KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay. Uses: Scientific research. Group: Signaling pathways. CAS No. 581073-80-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19735. | |
| KKII5 | KKII5 is a potent Lipoxygenase ( LOX-1 ) inhibitor with an IC 50 of 19 μM. KKII5 inhibits lipid peroxidation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6381-55-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W488004. | |
| KKL-40 | KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 865285-47-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116863. | |
| KL001 | KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 309928-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108468. | |
| KL-11743 | KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. In addition, KL-11743 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1369452-53-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145597. | |
| KL1333 | KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1800405-30-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128895. | |
| KL-50 | KL-50 is a selective toxin toward tumors that lack the DNA repair protein O 6 -methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O 6 -alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1161826-19-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164496. | |
| KM04416 | KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 26530-26-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148685. | |
| KMH-233 | KMH-233, a potent, reversible and selective inhibitor of l-type amino acid transporter LAT1/SLC7A5, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 ?M) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 ?M)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1941174-13-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120139. | |
| KN-93 | KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 139298-40-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465. | |
| KN-93 hydrochloride | KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1956426-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465A. | |
| KN-93 phosphate | KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II , with K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1913269-12-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15465B. | |
| KNK437 | KNK437 is a HSP inhibitor, and inhibits the induction of HSP105, HSP70, and HSP40. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Heat Shock Protein Inhibitor I. CAS No. 218924-25-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100110. | |
| KNT-127 | KNT-127 is a potent δ-opioid receptor agonist that crosses the blood-brain barrier (BBB). KNT-127 is highly selective to the δ receptor, with K i values of 0.16, 21.3 and 153 nM for δ, μ and κ receptors, respectively. KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens, and prefrontal cortex. KNT-127 has analgesic, antidepressant and antianxiety activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1256921-89-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-120511. | |
| Ko 143 | Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 461054-93-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10010. | |
| Kobe0065 | Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46±13 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 436133-68-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15716. | |
| Kojibiose | Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium , lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2140-29-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113133. | |
| Kojic acid | Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC 50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 501-30-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W050154. | |
| Kojic acid dipalmitate | Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus , Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin?lightening agent research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Kojic dipalmitate. CAS No. 79725-98-7. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W099579. | |
| KOTX1 | KOTX1 is an orally active and selective ALDH1A3 inhibitor. KOTX1 improves glucose tolerance, insulin secretion and blood sugar levels in diabetic mouse models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1788963-83-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164781. | |
| KP372-1 | KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an NQO1 redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such as head and neck squamous cell carcinoma (HNSCC) and pancreatic cancer) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1374996-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15673. | |
| KP-457 | KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1365803-52-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110397. | |
| Kp7-6 | Kp7-6, a Fas mimetic peptide, is a Fas/FasL antagonist. Kp7-6 protects cells from Fas-mediated apoptosis, and protects mice from Fas-mediated hepatic injury[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 629628-53-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10102. | |
| KPT-185 | KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations ( IC 50 =100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1333151-73-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15611. | |
| KPT-6566 | KPT-6566 is a selective and covalent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 value of 640 nM and a Ki value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 881487-77-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123847. | |
| Kras4B G12D-IN-1 | Kras4B G12D-IN-1 is a Kras4B G12D inhibitor with anticancer effects. Kras4B G12D-IN-1 decreases Kras protein expression in mouse embryonic fibroblasts (MEF) expressing Kras4B G12D (WO2016179558A1, Comp 994566) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2042365-85-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153413. | |
| K-Ras G12C-IN-1 | K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629265-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18604. | |
| K-Ras G12C-IN-4 | K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS G12C [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376328-55-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128771. | |
| K-Ras(G12C) inhibitor 12 | K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor. K-Ras(G12C) inhibitor 12 acts on H1792 cells with an EC50 of 0.32 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1469337-95-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18707. | |
| KRAS G12C inhibitor 14 | KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC 50 of 18 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2349393-95-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125872. | |
| K-Ras(G12C) inhibitor 6 | K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2060530-16-5. Pack Sizes: 2 mg. Product ID: HY-107841. | |
| K-Ras(G12C) inhibitor 9 | K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1469337-91-4. Pack Sizes: 2 mg. Product ID: HY-12446. | |
| Kresoxim-methyl | Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent K d of 0.07 μM proving a high affinity for this enzyme [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAS 490 F. CAS No. 143390-89-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-125776. | |
| KRFK TFA | KRFK TFA, a peptide derived from TSP-1, can activate TGF-?. KRFK TFA promotes TGF-?-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach[1]. Uses: Scientific research. Group: Peptides. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3970A. | |
| KRIBB11 | KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 342639-96-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100872. | |
| KRpep-2d | KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research [1]. Uses: Scientific research. Group: Peptides. CAS No. 2098181-84-9. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P3277. | |
| KS100 | KS100 is a potent ALDH inhibitor with IC 50 s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408477-54-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146682. | |
| KS15 | KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 ?M) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1033781-20-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115672. | |
| KS370G | KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 105955-01-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-114683. | |
| KSPWFTTL | KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 153049-05-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3333. | |
| KSQ-4279 | KSQ-4279 (USP1-IN-1) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 is promising for research of cancers [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: USP1-IN-1. CAS No. 2446480-97-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145471. | |
| KT109 | KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC 50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGL&alpha. KT109 shows inhibitory activity against PLA2G7 (IC 50 =1 μM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402612-55-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18540. | |
| KT172 | KT172 is a DAGLβ inhibitor with an IC 50 value of 11 nM. KT172 can be used for the research of metabolic and inflammatory [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402612-56-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-18541. | |
| KT-253 | KT-253 is a p53 stabilizer and a PROTAC degrader for MDM2 ( DC 50 =0.4 nM). KT-253 inhibits the proliferation of cancer cell RS4;11 with an IC 50 of 0.3 nM, arrests the cell cycle at G2/M phase, and induces apoptosis. KT-253 exhibits antitumor efficacy in mouse models [1]. (Pink: ligand for target protein MDM2 ligand 4 (HY-170452); Black: linker (HY-W001478); Blue: ligand for E3 ligase cereblon (HY-163927)). Uses: Scientific research. Group: Signaling pathways. CAS No. 2713618-08-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170451. | |
| KT-333 | KT-333 is a molecular glues that degrades STAT3 protein. KT-333 mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL). KT-333 has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2502186-79-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-156730. | |
| KT-474 | KT-474 (KYM-001) is an orally active PROTAC IRAK4 degrader with antitumor activities [1]. KT-474 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KYM-001; PROTAC IRAK4 degrader-7. CAS No. 2432994-31-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-145483. | |
| KT5720 | KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor ( IC 50 =3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 + concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 108068-98-0. Pack Sizes: 50 μg; 100 μg. Product ID: HY-N6789. | |
| KT5823 | KT5823, a selective the cGMP-dependent protein kinase ( PKG ) inhibitor with an K i value of 0.23 μM, it also inhibits PKA and PKC with K i values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine -related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na + /I - symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 126643-37-6. Pack Sizes: 100 μg. Product ID: HY-N6791. | |
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