MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PAR-4 Agonist Peptide, amide TFA | PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 ( PAR-4 ) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist [1]. Uses: Scientific research. Group: Peptides. Alternative Names: PAR-4-AP TFA; AY-NH2 TFA. CAS No. 1228078-65-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1309A. |  |
| Paracetamol-cysteine TFA | Paracetamol-cysteine (TFA) is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (HY-66005) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1331891-93-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-139093A. | |
| Paradol | Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site. Uses: Scientific research. Group: Natural products. Alternative Names: [6]-Gingerone; [6]-Paradol. CAS No. 27113-22-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-14617. | |
| Paraherquamide E | Paraherquamide E is a fungal metabolite found in Penicillium charlesii. Paraherquamide E has antinematodal and antiparasitic effects [1]. Uses: Scientific research. Group: Natural products. CAS No. 125600-53-5. Pack Sizes: 500 μg. Product ID: HY-N10220. | |
| Paramethasone Acetate | Paramethasone acetate is a synthetic glucocorticoid, and shows anti-inflammatory and immunosuppressant activities [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1597-82-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107939. | |
| para-Nitroblebbistatin | para-Nitroblebbistatin is a derivative of Blebbistatin (HY-13813) and an inhibitor of myosin II. para-Nitroblebbistatin is photostable, non-cytotoxic, and non-phototoxic. para-Nitroblebbistatin can serve as an ideal substitute for Blebbistatin (HY-13813) to study the role of myosin II in physiology, development, and cell biology[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1621326-32-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120870. | |
| Para-nitrophenyllinoleate | Para-nitrophenyllinoleate is an ester product. Uses: Scientific research. Group: Signaling pathways. CAS No. 6562-50-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-165831. | |
| Pararosaniline hydrochloride | Pararosaniline hydrochloride (Basic red 9) is a pH-responsive basic dye, as a biological stain to track certain proteins. The pH of the acidified Pararosaniline hydrochloride reagent has a significant effect on the color and the maximum absorption wavelength (λmax) of the reaction system, with its optimum pH 0.48 and a λmax at 549?nm. Pararosaniline hydrochloride is also a strong modifier of RNA splicing. Pararosaniline hydrochloride has been used in the analysis of SO 2 and formaldehyde and staining of bacteria or other organisms. Pararosaniline hydrochloride is extensively used in industries like textile, printing, paper, cosmetic, and leather [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Basic red 9. CAS No. 569-61-9. Pack Sizes: 10 g; 25 g. Product ID: HY-W127770. | |
| Parathyroid Hormone (1-34), bovine | Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis [1]. Uses: Scientific research. Group: Peptides. CAS No. 12583-68-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1252. | |
| Parathyroid hormone (1-34) (rat) | Parathyroid hormone (1-34) (rat) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 98614-76-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P2279. | |
| Paraxanthine | Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels. Uses: Scientific research. Group: Natural products. CAS No. 611-59-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W016498. | |
| Parbendazole | Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC 50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF 29044. CAS No. 14255-87-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115364. | |
| Parcetasal | Paclitaxal is a non-steroidal anti-inflammatory analgesic. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MR-897. CAS No. 87549-36-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-U00100. | |
| Pardoprunox hydrochloride | Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC 50 s of 8, 9.2, and 6.3, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SLV-308 hydrochloride; DU-126891 hydrochloride. CAS No. 269718-83-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14958A. | |
| Parecoxib | Parecoxib (SC 69124) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SC 69124. CAS No. 198470-84-7. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-17474. | |
| Parecoxib Sodium | Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the proagent of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SC 69124A. CAS No. 198470-85-8. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-17474A. | |
| Pargyline | Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K i s of 13 μM and 0.5 μM for MAO-A and MAO-B , respectively. Pargyline has antihypertensive and anticancer activities [1] [2] [3]. Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 555-57-7. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-A0091A. | |
| Pargyline hydrochloride | Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with K i s of 13 μM and 0.5 μM for MAO-A and MAO-B , respectively. Pargyline hydrochloride has antihypertensive and anticancer activities [1] [2] [3]. Pargyline (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 306-07-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-A0091. | |
| Paricalcitol | Paricalcitol, a vitamin D analogue, is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. Uses: Scientific research. Group: Signaling pathways. CAS No. 131918-61-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50919. | |
| Pariceract | Pariceract (LTI-291) is an activator of glucocerebrosidase (Gcase), with activation rates of more than 60% (1 ?M) and between 10%-20% (0.1 ?M). Pariceract can be used for Parkinson's disease and endometriosis research[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LTI-291; BIA 28-6156. CAS No. 1919820-28-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104038. | |
| Paridiprubart | Paridiprubart (NI-0101) is a humanised anti-TLR4 monoclonal antibody. Paridiprubart has the potential for the research of rheumatoid arthritis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: NI-0101. CAS No. 2641646-59-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145645. | |
| Paritaprevir | Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC 50 s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor) [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-450; Veruprevir. CAS No. 1216941-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12594. | |
| Parmodulin 2 | Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 ?M[1]. Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML161. CAS No. 423735-93-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13965. | |
| Paromomycin sulfate | Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Aminosidine sulfate. CAS No. 1263-89-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B0956. | |
| Paroxetine | Paroxetine is an oral | |
| Paroxetine hydrochloride | Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an GRK2 inhibitor with IC 50 of 14?μM. Paroxetine hydrochloride can be used for the research of depressive disorder [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRL29060 hydrochloride; BRL29060A. CAS No. 78246-49-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0492. | |
| Paroxetine hydrochloride hemihydrate | Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC 50 of 14?μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate. CAS No. 110429-35-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0492A. | |
| PARP10-IN-2 | PARP10-IN-2 is a potent mono?ADP?ribosyltransferase PARP10 inhibitor with an IC 50 of 3.64 μM for human PARP10. PARP10-IN-2 reveals potent inhibition on PARP2 and PARP15 with IC 50 s of 27 μM and 11 μM for human PARP2 and human PARP15, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1042780-52-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148753. | |
| PARP10-IN-3 | PARP10-IN-3 is a selective mono?ADP?ribosyltransferase PARP10 inhibitor with an IC 50 of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC 50 s of 1.7 μM for human PARP2 and human PARP15, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225800-19-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148754. | |
| PARP1-IN-11 | PARP1-IN-11 (compound 49) is a potent PARP1 inhibitor with IC 50 value of 0.082 μM. PARP1-IN-11 shows complete inhibition of PARP2 and substantially inhibits PARP3, TNKS1 and TNKS2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2482484-87-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147886. | |
| PARP-1-IN-2 | PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC 50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 684234-55-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-147027. | |
| PARP1-IN-29 | PARP1-IN-29 is an orally active PARP-1 inhibitor with an IC 50 value of 6.3 nM. PARP1-IN-29, after being labeled with [18F], can be used for positron emission tomography (PET) imaging, specifically targeting PARP-1 in tumors. PARP1-IN-29 is applicable in the fields of oncology and imaging research, particularly for detecting PARP-1 activity in cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1567375-93-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-164475. | |
| PARP-1-IN-3 | PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC 50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 induces apoptosis and arrest cell cycle at G2/M phase. PARP-1-IN-3 can be used in research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2976342-33-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-149800. | |
| PARP1-IN-31 | PARP1-IN-31 (compound 11f) is a phthalazinone-based compound, an anti-lung adenocarcinoma compound with inhibitory activity against PARP-1 ( IC 50 value of 97 nM), inducing apoptosis and inhibiting cell proliferation in lung cancer cell lines. Uses: Scientific research. Group: Signaling pathways. CAS No. 684234-60-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-164713. | |
| PARP1-IN-33 | PARP1-IN-33 (Example 6) is a PARP1 inhibitor ( IC 50 : 0.41 nM). PARP1-IN-33 has retinal cytoprotective effect, with an EC 50 of 0.02 nM (inhibition on MTS activity of H 2 O 2 induced human retinal pigment epithelial cell) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2640677-68-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164926. | |
| PARP-1-IN-4 | PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC 50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 684234-56-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153590. | |
| PARP1-IN-8 | PARP1-IN-8 (compound 11c) is a potent and BBB-penetrated PARP1 inhibitor, with an IC 50 of 97 nM. PARP1-IN-8 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 836640-15-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-147030. | |
| PARP7-IN-15 | PARP7-IN-15 (Compound 18) is a PARP7 inhibitor with IC 50 of 0.56 nM, that has antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2819998-97-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155351. | |
| Parsaclisib | Parsaclisib (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ , with an IC 50 of 1 nM at 1 mM ATP. Parsaclisib shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib can be used for the research of relapsed or refractory B-cell malignancies [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB050465; IBI-376. CAS No. 1426698-88-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109068. | |
| Parsaclisib hydrochloride | Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kδ , with an IC 50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB050465 hydrochloride; IBI-376 hydrochloride. CAS No. 1995889-48-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109068A. | |
| Parsatuzumab | Parsatuzumab (Anti-EGFL7; RG 7414) is a humanized monoclonal antibody, acts as an immunomodulator and binds to EGFL7. Parsatuzumab selectively blocks the interaction between EGFL7 and endothelial cells, potentially inhibiting vascular regrowth and reducing vascular endothelial growth factor ( VEGF ) inhibition [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-EGFL7; RG 7414. CAS No. 1312797-14-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99215. | |
| Parthenolide | Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-?B activation; also inhibits HDAC1 protein without affecting other class I/II HDACs. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Parthenolide. CAS No. 20554-84-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N0141. | |
| Pascolizumab | Pascolizumab (SB-240683) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab has the potential for the research of asthma [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SB-240683. CAS No. 331243-22-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99801. | |
| Pasireotide | Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5 , pK i =8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: SOM230. CAS No. 396091-73-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-16381. | |
| Pasireotide acetate | Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5 , pK i =8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: SOM230 acetate. CAS No. 396091-76-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16381A. | |
| Pasotuxizumab | Pasotuxizumab (BAY 2010112) is a PSMA and CD3 bispecific T-cell engager (BiTE). Pasotuxizumab binds to CD3 and PSMA with K D s of 9.4 nM and 47.0 nM for human CD3 and PSMA. Pasotuxizumab can be used for research of metastatic castration-resistant prostate cancer (mCRPC) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BAY 2010112; AMG 212. CAS No. 1442657-12-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99802. | |
| Patamostat | Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC 50 s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E-3123. CAS No. 114568-26-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114080. | |
| Patchouli alcohol | Patchouli alcohol is a natural tricyclic sesquiterpene, exhibits anti- Helicobacter pylori , anti-inflammatory and antioxidant properties [1]. Uses: Scientific research. Group: Natural products. CAS No. 5986-55-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N0207. | |
| Pateclizumab | Pateclizumab (MLTA3698A) is a humanized antibody against lymphotoxin α (LTα) , a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MLTA3698A; RG7415; PRO283698. CAS No. 1202526-59-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990034. | |
| Patent Blue V | Patent Blue V (Acid blue 1) is a novel biological dye that can be used as an intraocular dye for retinectomy. Retinectomy refers to the removal of the translucent inner limiting membrane (ILM). The application of appropriate dyes in vitreoretinal surgery can achieve the purpose of complete removal. Patent Blue V can be used to stain retinal premembranous structures. Spectral analysis shows that Patent Blue V has strong absorption below 450 nm and above 600 nm, showing a blue-green color. Patent Blue V is also used as a marker in lymphangiography for resection of neoplastic lymph nodes [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Acid blue 1. CAS No. 129-17-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W110929. | |
| Patent Blue V calcium salt | Patent Blue V has been widely used in sentinel lymph node mapping. Patent Blue V is also a food coloring agent and an alternative dye for trypan blue (TB) in descemet membrane endothelial keratoplasty (DMEK) [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 3536-49-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-126395. | |
| Patiromer | Patiromer is an orally active and potent hyperkalemia inhibitor and a nonabsorbed potassium binder. Patiromer polymer is bound with calcium which is released in the colon in exchange for binding potassium [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1208912-84-8. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-112961. | |
| Patisiran sodium | Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1386913-72-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132609. | |
| Patritumab | Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR , HER2 , HER3 , ERK , and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Human Anti-ERBB3 Recombinant Antibody. CAS No. 1262787-83-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99275. | |
| Patritumab deruxtecan | Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: HER3-DXd; U3-1402. CAS No. 2227102-46-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99813. | |
| Patulin | Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus , Penicillium , and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Terinin. CAS No. 149-29-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N6779. | |
| PAWI-2 | PAWI-2 is a p53 -Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1448427-02-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-123929. | |
| Paxalisib | Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR , with K i s of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0084. CAS No. 1382979-44-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19962. | |
| Paxilline | Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 ?M to 50 ?M for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity[1][2][3][4][5][6]. Uses: Scientific research. Group: Natural products. CAS No. 57186-25-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6778. | |
| Pazopanib | Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1 , VEGFR2 , VEGFR3 , PDGFRβ , c-Kit , FGFR1 , and c-Fms with IC 50 s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW786034. CAS No. 444731-52-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10208. | |
| Pazopanib Hydrochloride | Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1 , VEGFR2 , VEGFR3 , PDGFRβ , c-Kit , FGFR1 , and c-Fms with an IC 50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW786034 Hydrochloride. CAS No. 635702-64-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12009. | |
| Pazufloxacin mesylate | Pazufloxacin (T-3761) mesylate is a fluoroquinolone antibiotic. Uses: Scientific research. Group: Signaling pathways. Alternative Names: T-3762; Pazufloxacin methanesulfonate; Pazufloxacin mesilate. CAS No. 163680-77-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0724A. | |
| PB038 | PB038 is a Drug-liker containing a PEG unit and a cleavable linker attached to Exatecan[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2851058-71-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-153180. | |
| PB1 | PB1 is a potent intracellular disulfide reducing agent with several advantages including good cell permeability, the ability to form a high intracellular concentration gradient, and stability. PB1 is a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 increases retinal ganglion cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB1 can be used for the research of neuroprotective [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 188714-28-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138648. | |
| PB2 | PB2 is a tris(2-carboxyethyl)phosphine (TCEP) analogue increasing retinal ganglion (RGCs) cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB2 is substantially more permeable than TCEP. PB2, as a reducing agent, is highly neuroprotective for RGCs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 914940-24-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138649. | |
| PB28 dihydrochloride | PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a K i of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with a K i of 0.38 nM. PB28 dihydrochloride is less affinity for other receptors. PB28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum with EC 50 values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride can modulate SARS-CoV-2-human protein-protein interaction. PB28 dihydrochloride induces caspase-independent apoptosis and has antitumor activity [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 172907-03-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108511. | |
| PB94 | PB94 is a selective HDAC11 inhibitor (IC50=108 nM). PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3032970-74-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149766. | |
| PBB3 | PBB3 is a tracer of tau PET. PBB3 can be used to detect levels of tau protein in Alzheimer's disease and non-Alzheimer's disease[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1565796-97-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114616. | |
| PBFI-AM | PBFI-AM is a useful tool to determine intracellular K + content [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 124549-23-1. Pack Sizes: 1 mg. Product ID: HY-136872. | |
| PBIT | PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 ( JARID1 ) enzymes. PBIT inhibits JARID1B ( KDM5B or PLU1 ) histone demethylase with an IC 50 of about 3 μM. PBIT also inhibits JARID1A and JARID1C with IC 50 s of 6 μM and 4.9 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2514-30-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101451. | |
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