MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PBP10 | PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 [1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects [2]. Uses: Scientific research. Group: Peptides. CAS No. 794466-43-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1116. |  |
| PBR28 | PBR28 is an TSPO modulator, which can be used for prevention research of Pulmonary Arterial Hypertension (PAH). PBR28 can be used to trace 18 KDa transporter (TSPO) by adding radioactive labeling, which plays an important role in brain positron emission tomography (PET) imaging studies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 253307-65-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153248. | |
| (-)-p-Bromotetramisole oxalate | (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate. CAS No. 62284-79-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19695. | |
| PBT 1033 | PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PBT 2. CAS No. 747408-78-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-105321. | |
| PBT434 mesylate | PBT434 methanesulfonate is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 methanesulfonate can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 methanesulfonate inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 methanesulfonate prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 methanesulfonate has the potential for the research of Parkinsons disease (PD) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ATH434 mesylate. CAS No. 2387898-69-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120475A. | |
| PC945 | PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B , with IC 50 s of 0.23 μM and 0.22 μM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1931946-73-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117766. | |
| PCAF-IN-1 | PCAF-IN-1 is a highly selective PCAF inhibitor. PCAF-IN-1 is a antitumor agents, which can be used in tumor research research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2439194-86-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147894. | |
| PC-Biotin-PEG4-NHS carbonate | PC-Biotin-PEG4-NHS carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055198-03-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140135. | |
| PCC0208017 | PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC50s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2623158-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139604. | |
| PC DBCO-PEG4-NHS ester | PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. PC DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055025-02-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-138756. | |
| PCI-34051 | PCI-34051 is a potent and selective HDAC8 inhibitor with IC 50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms. Uses: Scientific research. Group: Signaling pathways. CAS No. 950762-95-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15224. | |
| PCO371 | PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613373-33-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100856. | |
| p-Coumaric acid | p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial , anti-inflammatory, antioxidant and anti-tumor activities [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: trans-4-Hydroxycinnamic acid. CAS No. 501-98-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g. Product ID: HY-N0351. | |
| PCPA methyl ester hydrochloride | PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Chloro-DL-phenylalanine methyl ester hydrochloride. CAS No. 14173-40-1. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-101456. | |
| p-Cresol glucuronide | p-Cresol glucuronide, a metabolite of p-cresol, is a prototype protein-bound uremic toxin. p-Cresol glucuronide is associated with chronic kidney disease (CKD) [1]. Uses: Scientific research. Group: Natural products. CAS No. 17680-99-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W416250. | |
| p-Cresyl sulfate | p-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1? and VHL, decreases the protein expression of HIF-2?. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT). p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: p-Tolyl sulfate. CAS No. 3233-58-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-111431. | |
| p-Cresyl sulfate potassium | p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: p-Tolyl sulfate potassium. CAS No. 91978-69-7. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-111431A. | |
| PCS1055 | PCS1055 is a selective and competitive antagonist for muscarinic M4 receptor with an IC 50 of 18.1 nM and a K d of 5.72 nM. PCS1055 inhibits radioligand [ 3 H]-NMS binding to the M4 receptor with a K i of 6.5 nM. PCS1055 is also an inhibitor for AChE with IC 50 of 22 nM and 120 nM for electric eel and human AChE, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 357173-55-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-122203A. | |
| PCS1055 dihydrochloride | PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC 50 of 18.1 nM and a K d of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [ 3 H]-NMS binding to the M4 receptor with a K i of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC 50 s of 22 nM and 120 nM for electric eel and human AChE , respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 361979-40-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-122203. | |
| PCSK9-IN-11 | PCSK9-IN-11 (compound 5r) is a potent and orally active PCSK9 inhibitor. PCSK9-IN-11 exhibits PCSK9 transcriptional inhibitory activity in HepG2 cells, with an IC 50 of 5.7 μM. PCSK9-IN-11 increases LDL receptor (LDLR) protein level. PCSK9-IN-11 can be used for atherosclerosis research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2882035-56-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152223. | |
| PCSK9-IN-23 | PCSK9-IN-23 (compound 5C) is a potent PCSK9 inhibitor. PCSK9-IN-23 blocks PCSK9 secretion from HepG2 cells, significantly increases LDL receptor (LDLR) expression [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2115700-96-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-157434. | |
| PD0166285 | PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 ?M for Chk1[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 185039-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13925. | |
| PD0176078 | PD0176078 is a newly found N-type Calcium channel blocker. Uses: Scientific research. Group: Signaling pathways. CAS No. 248922-46-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00236. | |
| PD 102807 | PD 102807 is a M4 muscarinic receptor antagonist with an IC 50 of 90.7 nM. PD 102807 inhibits M1, M2, M3, M5 muscarinic receptor with IC 50 s of 6558.7, 3440.7, 950.0, and 7411.7 nM, respectively [1]. Antidyskinetic effect. Uses: Scientific research. Group: Signaling pathways. CAS No. 23062-91-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107646. | |
| PD 123319 ditrifluoroacetate | PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC 50 of 34 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 136676-91-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10259A. | |
| PD 128042 | PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 ?M). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI 976. CAS No. 114289-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107572. | |
| (+)-PD 128907 hydrochloride | (+)-PD 128907 hydrochloride is a selective dopamine D 2 /D 3 receptor agonist, with K i s of 1.7, 0.84 nM for human and rat D 3 receptors, 179, 770 n M for human and rat D 3 receptors, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 300576-59-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110000. | |
| PD 128907 hydrochloride | PD 128907 (hydrochloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 112960-16-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100539A. | |
| PD150606 | PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with K i values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 179528-45-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100529. | |
| PD153035 | PD153035 (SU-5271; AG1517; ZM 252868) is a potent EGFR inhibitor with K i and IC 50 of 6 and 25 pM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU-5271; AG1517; ZM 252868. CAS No. 153436-54-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14346. | |
| PD153035 Hydrochloride | PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potent EGFR inhibitor with K i and IC 50 of 6 and 25 pM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU-5271 Hydrochloride; AG1517 Hydrochloride; ZM 252868 Hydrochloride. CAS No. 183322-45-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12013. | |
| PD-156707 | PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 162412-70-6. Pack Sizes: 5 mg. Product ID: HY-123744. | |
| PD-161570 | PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively[1][2]. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-? signaling inhibitor[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 192705-80-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100434. | |
| PD166326 | PD166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases , with IC 50 s of 6 nM and 8 nM for Src and Abl , respectively. PD166326 exhibits antileukemic activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 185039-91-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118144. | |
| PD-166866 | PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC 50 of 52.4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 192705-79-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101296. | |
| PD-168077 maleate | PD-168077 maleate is a selective dopamine D 4 receptor agonist, with a K i of 9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 630117-19-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-21098A. | |
| PD168393 | PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 194423-15-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13896. | |
| PD 169316 | PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71. Uses: Scientific research. Group: Signaling pathways. CAS No. 152121-53-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10578. | |
| PD173074 | PD173074 is a potent FGFR1 inhibitor with an IC50 of 25 nM and also inhibits VEGFR2 with an IC50 of 100-200 nM, showing 1000-fold selectivity for FGFR1 over PDGFR and c-Src. Uses: Scientific research. Group: Signaling pathways. CAS No. 219580-11-7. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10321. | |
| PD173952 | PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 305820-75-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122113. | |
| PD173955 | PD173955 is an orally active inhibitor of Src (IC50= 22 nM), Yes, Abl, ATP and MAP kinases. PD173955 can effectively prevent the mitotic process and has anticancer activity[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 260415-63-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10395. | |
| PD 174265 | PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC 50 of 450 pM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 216163-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112411. | |
| PD176252 | PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 ?M in HL-60 cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 204067-01-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103286. | |
| PD180970 | PD180970 is a highly potent and ATP-competitive p210Bcr-Abl kinase inhibitor, with an IC50 of 5 nM for inhibiting the autophosphorylation of p210Bcr-Abl. PD180970 also inhibits Src and KIT kinase with IC50s of 0.8 nM and 50 nM, respectively. PD180970 indcues apoptosis of K562 leukemic cells, and can be used for chronic myelogenous leukemia research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 287204-45-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-103274. | |
| PD-1/PD-L1-IN-14 | PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2499965-12-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144258. | |
| PD-1/PD-L1-IN-23 | PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester proagent of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2597056-04-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145774. | |
| PD318088 | PD318088 is a potent, allosteric and non-ATP competitive MEK1/2 inhibitor, an analog of PD184352 (HY-50295). PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. PD318088 can be used for cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 391210-00-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12062. | |
| PD 407824 | PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 622864-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18961. | |
| PD98059 | PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 μM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 μM) and MEK2 (IC50 of 50 μM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 ?M) and AHR transformation (IC50 of 1 ?M). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 167869-21-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12028. | |
| PDAT | PDAT is a noncompetitive indolethylamine-N-methyltransferase (INMT) inhibitor with a K i of 84 μM for rabbit lung INMT (rabINMT) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1226213-83-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124101. | |
| PDCD4-IN-1 | PDCD4-IN-1(compound 20031600) is a PDCD4 inhibitor with a K d value of 350 nM, which can promote the expression of BDNF in hippocampal neuron cell HT-22 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 494763-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153383. | |
| PdCl2(Amphos)2 | PdCl2(Amphos)2 is a catalyst that is more suitable for use in water than organic solvents [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 887919-35-9. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W010686. | |
| PDD00017272 | PDD00017272 is an inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (EC50=4.8 nM) and an activator of PARP1/2. PDD00017272 inhibits its activity of hydrolyzing poly(ADP-ribose) (pADPr), resulting in the accumulation of pADPr on chromatin, interfering with DNA damage repair and replication processes, and inducing PARP1/2-dependent cytotoxicity. PDD00017272 can be used in cancer models with DNA repair defects (such as BRCA mutations) or resistance to PARP inhibitors. PDD00017272 has a PARG expression level-correlated inhibitory potency with EC50 of 9.2 nM (PARG cells), the tumor cells with lower PARG expression are more sensitive[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1945950-20-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133531. | |
| PDD 00017273 | PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1945950-21-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-108360. | |
| PDDC | PDDC is a compound used to inhibit Alzheimer's disease. It is a nSMase2 inhibitor that can inhibit tau-induced nSMase2 activity and ceramide elevation, and slow the spread of tau in mouse models. Uses: Scientific research. Group: Signaling pathways. CAS No. 2232878-43-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156800. | |
| PDE-9 inhibitor | PDE-9 inhibitor is useful for neurodegenerative diseases. Uses: Scientific research. Group: Signaling pathways. CAS No. 1082743-70-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-50865. | |
| p-Dimethylaminobenzaldehyde | p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) can be used as a chromogenic reagent or as an absorbent agent for heavy metal ions [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Dimethylaminobenzaldehyde. CAS No. 100-10-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-Y0015. | |
| PDK1 allosteric modulator 1 | PDK1 allosteric modulator 1 is a molecule targeting PDK1 with a binding affinity of 8 μM. PDK1 allosteric modulator 1 is able to bind to the PIF pocket of PDK1, potentially affecting the biological activity of this kinase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 303134-93-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W837864. | |
| PDK4-IN-1 | PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2310262-10-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-135954. | |
| PDK4-IN-1 hydrochloride | PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 hydrochloride has antidiabetic, anticancer and anti-allergic activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2310262-11-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135954A. | |
| PD-L1-IN-1 | PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC 50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2767424-13-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139781. | |
| PD-L1-IN-2 | PD-L1-IN-2 is a potential tumor immunological agent by inhibiting PD-L1. PD-L1-IN-2 is a Naamidine J derivative and exerts antitumor effects in vivo by reducing PD-L1 expression and enhancing tumor-infiltrating T-cell immunity. PD-L1-IN-2 is used for colorectal cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2894733-91-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-149830. | |
| PD-L1-IN-3 | PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC 50 value and EC 50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2953044-29-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155101. | |
| PDM2 | PDM2 is a selective, high-affinity aryl hydrocarbon receptor ( AhR ) antagonist with an K i of 1.2±0.4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 688348-25-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112629. | |
| PDMP hydrochloride | PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 73257-80-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116392D. | |
| PE 22-28 | PE 22-28 is a TREK-1 inhibitor with IC 50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression [1]. Uses: Scientific research. Group: Peptides. CAS No. 1801959-12-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3581. | |
| PE859 | PE859 is a potent inhibitor of both tau and A? aggregation with IC50 values of 0.66 and 1.2 ?M, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402727-29-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12662. | |
| PEAQX tetrasodium hydrate | PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 ?M for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NVP-AAM077 tetrasodium hydrate. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12294A. | |
| Pectin | Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of agents. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 9000-69-5. Pack Sizes: 100 mg; 1 g; 5 g. Product ID: HY-W145518. | |
| Pectinase, aspergillus niger | Pectinase (EC 3.2.1.15) is a mixed enzymes that hydrolyze pectic substances, it mostly presents in microorganisms and higher plants. Pectinase is involved in the metabolism of the cell wall as well as in the growth of the cell, senescence, ripening of fruits, pathogenesis and abscission process [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EC 3.2.1.15. CAS No. 9032-75-1. Pack Sizes: 5 g; 10 g; 50 g. Product ID: HY-126386. | |
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