MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Synaptamide | Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-Docosahexaenoyl ethanolamine (DHEA); Docosahexaenoyl ethanolamide. CAS No. 162758-94-3. Pack Sizes: 5 mg (67 mM * 200 μL in Ethanol); 10 mg (67 mM * 400 μL in Ethanol). Product ID: HY-100197. |  |
| Synephrine | Synephrine (Oxedrine), an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine is a sympathomimetic compound and can be used for weight loss [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Oxedrine. CAS No. 94-07-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N0132. | |
| Synephrine hydrochloride | Synephrine (Oxedrine) hydrochloride, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Oxedrine hydrochloride. CAS No. 5985-28-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-N0132A. | |
| Syringaldehyde | Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis [1]. Syringaldehyde moderately inhibits COX-2 activity with an IC 50 of 3.5 μg/mL [2]. Anti-hyperglycemic and anti-inflammatory activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 134-96-3. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N1390. | |
| (-)-Syringaresinol | (-)-Syringaresinol, is the isoform of Syringaresinol (HY-N8307), which can be found in stems of Annona Montana , possesses anti-cancer activity. Syringaresinol is an activator of NO synthase phosphorylation and induces vasodilation. Syringaresinol also inhibits the NF-κB pathway and exerts anti-inflammatory activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 6216-81-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126066. | |
| (+)-Syringaresinol | (+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC 50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 21453-69-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-126030. | |
| Syringetin | Syringetin, a flavonoid derivative, is associated with increased BMP-2 production. Syringetin stimulates osteoblast differentiation at various stages, from maturation to terminally differentiated osteoblasts [1]. Uses: Scientific research. Group: Natural products. CAS No. 4423-37-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N8920. | |
| Syringetin-3-O-glucoside | Syringetin-3-O-glucosid (Syringetin 3-O-β-D-glucoside), a flavonol glycoside, shows relatively weak DPPH and ABTS radical scavenging activity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Syringetin 3-O-β-D-glucoside. CAS No. 40039-49-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N8194. | |
| Syringic acid | Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation. Uses: Scientific research. Group: Natural products. CAS No. 530-57-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-N0339. | |
| Syringic acid (Standard) | Syringic acid (Standard) is the analytical standard of Syringic acid. This product is intended for research and analytical applications. Syringic acid is correlated with high antioxidant activity and inhibition of LDL oxidation. Uses: Scientific research. Group: Natural products. CAS No. 530-57-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0339R. | |
| Syringin | Syringin (Eleutheroside B) is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Eleutheroside B. CAS No. 118-34-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N0824. | |
| Systemin | Systemin, an 18-amino acid polypeptide, has been isolated from tomato leaves that is a powerful inducer of over 15 defensive genes. Uses: Scientific research. Group: Peptides. CAS No. 137181-56-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0279. | |
| T-00127_HEV1 | T-00127_HEV1 is a phosphatidylinositol 4-kinase III beta ( PI4KB ) inhibitor with an IC 50 of 60 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 900874-91-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-108313. | |
| T-5224 | T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 530141-72-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12270. | |
| T5342126 | T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells ( IC 50 =27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood ( IC 50 s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice. Uses: Scientific research. Group: Signaling pathways. CAS No. 956507-49-6. Pack Sizes: 1 mg (21.83 mM * 100 μL in Methyl acetate); 5 mg (21.83 mM * 500 μL in Methyl acetate); 10 mg (21.83 mM * 1 mL in Methyl acetate). Product ID: HY-123789. | |
| T7 RNA polymerase | T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg 2+ , T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9014-24-8. Pack Sizes: 1 KU; 5 KU. Product ID: HY-E70090. | |
| T7 Tag Peptide | T7 Tag Peptide is a protein tag derived from the N-terminal 11 residues of the major T7 capsid protein, gp 10. T7 Tag Peptide can be used in different immunoassays as well as affinity purification [1]. Uses: Scientific research. Group: Peptides. CAS No. 245445-88-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P0327. | |
| TA-02 | TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC 50 of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1784751-19-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100115. | |
| Tabalumab | Tabalumab (LY2127399) is a human anti- BAFF ( B-cell activating factor ) monoclonal antibody (IgG4 type) with neutralising activity against membrane bound and soluble BAFF. Tabalumab can be used in studies of autoimmune diseases such as rheumatoid arthritis, renal failure and systemic lupus erythematosus [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY2127399. CAS No. 1143503-67-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99220. | |
| Tabersonine | Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS [1]. Uses: Scientific research. Group: Natural products. CAS No. 4429-63-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N1431. | |
| TACA | TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABA A and GABA C receptors ( K D = 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: trans-4-Aminocrotonic acid. CAS No. 38090-53-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100800. | |
| Tacalcitol | Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3. CAS No. 57333-96-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-32337. | |
| Tacalcitol monohydrate | Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1,24(R)-Dihydroxyvitamin D3 monohydrate. CAS No. 93129-94-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-32338. | |
| Tacedinaline | Tacedinaline (N-acetyldinaline) is an inhibitor of the histone deacetylase ( HDAC ) with IC 50 s of 0.9, 0.9, 1.2 μM for recombinant HDAC 1, 2 and 3 respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-acetyldinaline; CI-994; Goe-5549. CAS No. 112522-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50934. | |
| Tacrine | Tacrine is an effective oral acetylcholine (AChE) inhibitor ( IC 50 = 109 nM) and also acts as an active substrate for CYP1A2. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 321-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-111338. | |
| Tacrine hydrochloride | Tacrine hydrochloride is a potent inhibitor of both AChE and BChE , with IC 50 s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC 50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimers disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1684-40-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1488. | |
| Tacrine hydrochloride (hydrate) | Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl ( AChE ) and butyryl-cholinestrase ( BChE ) with IC 50 s of 31 nM and 25.6 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 206658-92-6. Pack Sizes: 100 mg. Product ID: HY-B2244. | |
| Tacrolimus | Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase , which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties [1]. Uses: Scientific research. Group: Natural products. Alternative Names: FK506; Fujimycin; FR900506. CAS No. 104987-11-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13756. | |
| Tacrolimus monohydrate | Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase , which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties [1]. Uses: Scientific research. Group: Natural products. Alternative Names: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate. CAS No. 109581-93-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13756A. | |
| Tadalafil | Tadalafil (IC-351) is a PDE5 inhibitor with an IC 50 value of 1.8 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IC-351. CAS No. 171596-29-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-90009A. | |
| Tafamidis | Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC 50 s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 594839-88-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14852. | |
| Tafamidis meglumine | Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC 50 s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Fx-1006A. CAS No. 951395-08-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14852A. | |
| Tafasitamab | Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigen CD19 [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: XmAb5574; MOR00208; Tafasitamab-cxix. CAS No. 1422527-84-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9981. | |
| Tafenoquine | Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WR 238605. CAS No. 106635-80-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111529. | |
| Tafenoquine Succinate | Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WR 238605 Succinate. CAS No. 106635-81-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111529A. | |
| Tafetinib | Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibits stem cell factor receptor (Kit) , vascular endothelial growth factor receptor-2 (VEGFR-2) , platelet-derived growth factor receptor-β (PDGFR-β) , glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET) , and Fms-like tyrosine kinase-3 (FLT3) with IC 50 values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation of PDGFR-β and VEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SIM010603. CAS No. 1032265-57-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-116116. | |
| Tafluprost | Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn 2+ - mTOR pathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AFP-168; MK2452. CAS No. 209860-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0600. | |
| Tafluprost acid | Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with K i and EC 50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor ( IC 50 =67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AFP-172. CAS No. 209860-88-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0601. | |
| Tafolecimab | Tafolecimab (IBI-306) is a human lgG2 monoclonal antibody that specifically binds PCSK-9 and reduces LDL-C levels by inhibiting PCSK-9-mediated endocytosis of the LDL receptor, which in turn enhances clearance of LDL-C and leads to a reduction in LDL-C levels. Tafolecimab may be used in studies of hypercholesterolaemia [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IBI-306. CAS No. 2225109-03-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99552. | |
| Tagitanlimab | Tagitanlimab (HBM-9167) is a humanized anti-PD-L1 antibody (IgG1κ type). Tagitanlimab selectively blocks the interaction of PD-L1 and PD-1. Tagitanlimab has the potential to be studied in recurrent or metastatic nasopharyngeal carcinoma (NPC) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: HBM-9167; KL-A167. CAS No. 2417649-97-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99544. | |
| TAK-071 | TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC 50 of TAK-071 M1R agonist activities is 520 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820812-16-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122190. | |
| TAK1-IN-3 | TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 494772-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115743. | |
| TAK-243 | TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor ( IC 50 =1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN7243. CAS No. 1450833-55-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100487. | |
| TAK-441 | TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC 50 value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186231-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16475. | |
| TAK-960 | TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1) , with an IC 50 of 0.8 nM. TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC 50 s of 16.9 and 50.2 nM, respectively. TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1137868-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15160. | |
| Talabostat mesylate | Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor ( IC 50 < 4 nM; K i = 0.18 nM) and the inhibitor of fibroblast activation protein (FAP) ( IC 50 = 560 nM), inhibits DPP8/9 ( IC 50 = 4/11 nM; K i = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) ( IC 50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Val-boroPro mesylate; PT100 mesylate. CAS No. 150080-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13233A. | |
| Talacotuzumab | Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123 -neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K D s of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: JNJ 56022473; CSL 362. CAS No. 1826831-79-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99395. | |
| Taladegib | Taladegib (LY2940680) is an antagonist of the smoothened receptor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY2940680. CAS No. 1258861-20-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13242. | |
| Talampanel | Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity [1]. Talampanel (IVAX) has neuroprotective effects in rodent stroke models [2]. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GYKI-53773; LY-300164. CAS No. 161832-65-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15079. | |
| Talaporfin sodium | Talaporfin (ME2906) sodium is a chlorin based photosensitizer. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ME2906; Mono-L-aspartyl chlorin e6; NPe6. CAS No. 220201-34-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16477. | |
| Talarozole | Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC 50 s of 5.4 and 0.46 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R115866. CAS No. 201410-53-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14531. | |
| (-)-Talarozole | (-)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 201410-67-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14802D. | |
| (+)-Talarozole | (+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 201410-66-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14802C. | |
| Talatisamine | Talatisamine, a aconitum alkaloid, is specific K + channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons [1]. Uses: Scientific research. Group: Natural products. CAS No. 20501-56-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0663. | |
| Talazoparib | Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with K i s of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMN-673; LT-673. CAS No. 1207456-01-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16106. | |
| Talazoparib tosylate | Talazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC 50 of 0.57 nM for PARP1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMN 673ts. CAS No. 1373431-65-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-108413. | |
| Taldefgrobep alfa | Taldefgrobep alfa (BMS 986089; RG 6206; RO 7239361) is a potent inhibitory antibody targeting to human myostatin. Taldefgrobep alfa is a fusion protein composed of a human IgG1-Fc domain and Adnectin domain. Taldefgrobep alfa can be used for spinal muscular atrophy (SMA) research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BMS 986089; RG 6206; RO 7239361; BHV2000. CAS No. 1580555-26-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99518. | |
| Taletrectinib | Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC 50 s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DS-6051b; AB-106; IBI-344. CAS No. 1505515-69-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131003. | |
| Talfirastide | Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity ( IC 50 =0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: TXA127; Angiotensin (1-7); Ang-(1-7). CAS No. 51833-78-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12403. | |
| Talfirastide acetate | Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity ( IC 50 =0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate. CAS No. 2855063-75-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12403A. | |
| Talinolol | Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cordanum. CAS No. 57460-41-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108286. | |
| Talizumab | Talizumab (TNX 901) is an anti-IgE humanized IgG1 monoclonal antibody [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TNX 901; Anti-Human IgE Fc Recombinant Antibody. CAS No. 380610-22-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99319. | |
| Talmapimod | Talmapimod (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC 50 of 9 nM. Talmapimod shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCIO-469. CAS No. 309913-83-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10406. | |
| Talniflumate | Talniflumate (BA 7602-06) is the proagent of Niflumic acid (HY-B0493), exerting its activity in the body through conversion to niflumic acid by esterase [1]. Talniflumate is an orally active Ca 2+ -activated Cl - channel (CaCC) blocker. Talniflumate can be used as an analgesic and anti-inflammatory agent in cystic fibrosis mouse model of distal intestinal obstructive syndrome [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BA 7602-06. CAS No. 66898-62-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103370. | |
| Talquetamab | Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: JNJ-64407564. CAS No. 2226212-40-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99394. | |
| Talsaclidine | Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes [1] [2] [3] [4]. Talsaclidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 147025-53-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-128855. | |
| Taltirelin | Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist ( IC 50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC 50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-0910. CAS No. 103300-74-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0596. | |
| Taltirelin acetate | Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist ( IC 50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC 50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-0910 acetate. CAS No. 1549593-23-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0596A. | |
| Tamarixetin | Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p ( ClpP ) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC 50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis , and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 4'-O-Methyl Quercetin. CAS No. 603-61-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N1181. | |
| TAME | TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC) , which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 901-47-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13255. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.