MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Anifrolumab | Anifrolumab is a type I interferon ( IFN ) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1326232-46-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99168. |  |
| Aniline Blue sodium | Aniline Blue sodium is a water-soluble dye commonly used as a biological stain for the detection of nucleic acids and proteins in various laboratory procedures such as electrophoresis and microscopy. Aniline Blue sodium has unique chemical properties that allow it to bind to specific cellular components, producing a color change that facilitates their visualization and analysis. Uses: Scientific research. Group: Fluorescent dye. CAS No. 28631-66-5. Pack Sizes: 10 g; 25 g. Product ID: HY-W133919. | |
| Aniline mustard | Aniline mustard (N, n-BIS (2-chloroethyl) aniline) is an anticancer agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N,N-Bis(2-chloroethyl)aniline. CAS No. 553-27-5. Pack Sizes: 10 mM * 1 mL; 5 g; 10 g; 25 g. Product ID: HY-121713. | |
| Anilofos | Anilofos is a pre-emergence, organophosphorus herbicide. Anilofos has moderate toxic potential in mammals [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 64249-01-0. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B2016. | |
| Aniracetam | Aniracetam (Ro 13-5057) is an orally active neuroprotective agent, possessing nootropics effects. Aniracetam potentiates the ionotropic quisqualate (iQA) responses in the CA1 region of rat hippocampal slices. Aniracetam also potentiates the excitatory post synaptic potentials (EPSPs) in Schaffer collateral-commissural synapses. Aniracetam can prevents the CO 2 -induced impairment of acquisition in hypercapnia model rats. Aniracetam can be used to research cerebral dysfunctional disorders [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 13-5057. CAS No. 72432-10-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-10932. | |
| Anisatin | Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant ( Illicium anisatum ) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC 50 of ~1.10?μM [1]. Uses: Scientific research. Group: Natural products. CAS No. 5230-87-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N9506. | |
| Anisindione | Anisindione is a synthetic anticoagulant. It inhibits the formation of active procoagulant factors II, VII, IX, and X. Uses: Scientific research. Group: Signaling pathways. CAS No. 117-37-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0924. | |
| Anisodamine | Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic , and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Hydroxyhyoscyamine. CAS No. 55869-99-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-N0584. | |
| Anisodamine hydrobromide | Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Hydroxyhyoscyamine hydrobromide. CAS No. 55449-49-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0584A. | |
| Anisylacetone | Anisylacetone (p-Methoxybenzylacetone) is a male fruit fly attractant [1]. Uses: Scientific research. Group: Natural products. Alternative Names: p-Methoxybenzylacetone. CAS No. 104-20-1. Pack Sizes: 10 mM * 1 mL; 50 g; 100 g. Product ID: HY-116047. | |
| Ankaflavin | Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 50980-32-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-N6642. | |
| Annonacin | Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W +/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 111035-65-5. Pack Sizes: 1 mg. Product ID: HY-N2877. | |
| Anonaine | Anonaine is an antiparasitic agent. Anonaine also is a glutathione S-transferase (GST) inhibitor [1]. Uses: Scientific research. Group: Natural products. CAS No. 1862-41-5. Pack Sizes: 1 mg. Product ID: HY-N7227. | |
| Anpirtoline hydrochloride | Anpirtoline (D-16949) hydrochloride is a centrally acting 5-HT 1B receptor agonist, with K i s of 28 nM (5-HT 1B ), 150 nM (5-HT 1A ) and 1.49 μM (5-HT2). Anpirtoline hydrochloride has serotonergic, antinociceptive, antidepressant-like effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-16949 hydrochloride. CAS No. 99201-87-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-101100. | |
| Anrikefon acetate | Anrikefon (HSK21542) acetate is a kappa opioid receptor agonist with analgesic effect [1]. Uses: Scientific research. Group: Peptides. Alternative Names: HSK21542 acetate. CAS No. 2584931-05-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3445A. | |
| Anrukinzumab | Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IMA-638. CAS No. 910649-32-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99439. | |
| ANS | ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor targeting thyroxine binding globulin (TBG) (K i =2.09×10 6 M -1 ). ANS is used in radioimmunoassay by displacing bound triiodothyronine (T3) to improve detection sensitivity. ANS can block the protein binding site of T3 and release free T3 for antibody recognition. As a fluorescent probe, ANS can specifically bind to the hydrophobic region of proteins (such as membrane proteins) and monitor the dynamics of protein conformation through changes in fluorescent signals. It is widely used in biochemical research and antibacterial material development [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: ANSA; 8-Anilino-1-naphthalenesulfonic acid. CAS No. 82-76-8. Pack Sizes: 1 g; 5 g. Product ID: HY-D0896. | |
| Ansamitocin P-3 | Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic. Uses: Scientific research. Group: Natural products. Alternative Names: Antibiotic C 15003P3; Maytansinol isobutyrate. CAS No. 66584-72-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15739. | |
| ANS ammonium | ANS ammonium is a potent antibacterial agent and a textile dye. ANS ammonium can be used as fluorescence probe. ANS ammonium blocks the binding of triiodothyronine to thyroxine binding globulin in radioimmunoassay of triiodothyronine [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: NSC 1746 ammonium; Peri acid, phenyl- ammonium; Phenyl peri acid ammonium. CAS No. 28836-03-5. Pack Sizes: 1 g; 5 g. Product ID: HY-D0896A. | |
| Anselamimab | Anselamimab (CAEL-101) a humanized IgG1-κ anti-Amyloid fibrils antibody targeting to serum amyloid A1 ( SAA1 ) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CAEL-101. CAS No. 2414866-63-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99105. | |
| Anserine | Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 584-85-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-113354. | |
| Ansofaxine hydrochloride | Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin , dopamine and norepinephrine reuptake with IC 50 values of 723, 491 and 763 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY03005; LPM570065. CAS No. 916918-84-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00096. | |
| Ansornitinib | Ansornitinib is an orally active dual kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2). Ansornitinib can be used as an antifibrotic agent in lung, liver, kidney, and gastrointestinal fibrotic diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ANG-3070. CAS No. 1448874-96-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147243. | |
| Ansuvimab | Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Ansuvimab-zyk; mAb114. CAS No. 2375952-29-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99337. | |
| Antalarmin | Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 ( CRHR1 ) antagonist with a K i of 2.7 nM. Antalarmin can pass through the blood - brain barrier [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 157284-96-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-124475. | |
| Antalarmin hydrochloride | Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a K i of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220953-69-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103377. | |
| Antazoline | Antazoline (Phenazoline) is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Phenazoline. CAS No. 91-75-8. Pack Sizes: 10 mg. Product ID: HY-B1067A. | |
| Antazoline hydrochloride | Antazoline (Phenazoline) hydrochloride is a first-generation antihistamine that also has anticholinergic properties and is used to relieve nasal congestion and is also used as eye drops. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Phenazoline hydrochloride. CAS No. 2508-72-7. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-B1067. | |
| Anthracene-9-carboxylic acid | Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca 2+ -activated Cl - currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 9-Anthracenecarboxylic acid. CAS No. 723-62-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-101329. | |
| Anthracene-9-carboxylic acid-d9 | Anthracene-9-carboxylic acid-d 9 is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: 9-Anthracenecarboxylic acid-d9. CAS No. 1219803-78-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101329S. | |
| Anthragallol | Anthragallol can insert base pairs of DNA. Anthragallol exhibits cytotoxicity by binding to DNA [1]. Uses: Scientific research. Group: Natural products. CAS No. 602-64-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-119840. | |
| Anthraquinone | Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via Apoptosis [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 84-65-1. Pack Sizes: 25 g; 50 g. Product ID: HY-N0354. | |
| Anthraquinone-2-carboxylic acid | Anthraquinone-2-carboxylic acid is a major anthraquinone isolated from Brazilian taheebo , with anti-inflammatory activity and antinociceptive [1]. Uses: Scientific research. Group: Natural products. CAS No. 117-78-2. Pack Sizes: 10 mM * 1 mL; 250 mg; 500 mg. Product ID: HY-W031757. | |
| Anthrone | Anthrone is an organic compound commonly used as a dye and intermediate. It can be used to make products such as pigments, dyes and fluorescent whitening agents, and is widely used in certain industrial production fields such as textile manufacturing, soap making and paper making. In addition, this compound is also used as a reagent and catalyst in some organic synthesis reactions. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Anthracen-9(10H)-one. CAS No. 90-44-8. Pack Sizes: 1 g; 5 g. Product ID: HY-W009938. | |
| Antide | Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer [1]. Uses: Scientific research. Group: Peptides. Alternative Names: D-21074; ORF 23541. CAS No. 112568-12-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0013. | |
| Antifreeze Polypeptide 6 (winter flounder) | Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei [1]. Uses: Scientific research. Group: Peptides. CAS No. 122604-16-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3832. | |
| Antihistamine-1 | Antihistamine-1 is a H1-antihistamine ( K i =6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC 50 s of 5.4 and 0.8 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186430-60-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100238. | |
| Antineoplaston A10 | Antineoplaston A10 is an antineoplaston that inhibits the growth of human hepatoma cells by inducing apoptosis. Antineoplaston A10 can be used in the study of liver cancer and breast cancer [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 91531-30-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128553. | |
| Antioxidant 1010 | Antioxidant 1010 (lrganox 1010; AT1010) exhibits antioxidant efficacy in plastic, rubber and synthetic fiber [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: lrganox 1010; AT1010. CAS No. 6683-19-8. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-W010653. | |
| Antioxidant agent-11 | Antioxidant agent-11 (compound 3d) is a compound that has weak anti-cancer and antioxidant activities [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 474379-42-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153757. | |
| Antipain dihydrochloride | Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37682-72-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-127034. | |
| Antiproliferative agent-14 | Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC 50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1885900-35-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148265. | |
| Antipyrine | Antipyrine (Phenazone) is an orally active antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine also delays gastric emptying (GE) in rats [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Phenazone; Phenazon. CAS No. 60-80-0. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B0171. | |
| Antituberculosis agent-5 | Antituberculosis agent-5 (compound 52) is a nitrofuranylamide derivative, inhibits M. tuberculosis UDP-Gal mutase. Antituberculosis agent-5 inhibits Glf activity with an IC 50 value of 99 μM/mL and resists tuberculosis (TB) with a MIC value of 1.6 μg/mL [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 313981-44-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151514. | |
| Antitumor agent-171 | Antitumor agent-171 (Compound 35) is an inhibitor for β-catenin/BCL9 interaction with IC 50 of 1.61 μM. Antitumor agent-171 exhibits high affinity to β-catenin with K d of 0.63 μM. Antitumor agent-171 inhibits the gene expression of axin2 with IC 50 of 0.84 μM. Antitumor agent-171 inhibits cell viability of HCT116 with IC 50 of 4.39 μM. Antitumor agent-171 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3003004-76-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-163767. | |
| Anti-virus agent 1 | Anti-virus agent 1 (compound 4i), a phosphoramidate proagent of GS-5734 (HY-104077; Remdesivir), has potent antiviral activity. Anti-virus agent 1 is used for the research of coronavirus and Ebola virus (EBOV) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Remdesivir isopropyl ester analog. CAS No. 1911578-83-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131233. | |
| Antroquinonol | Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata , has hepatoprotective, anti-inflammatory, and anti-cancer effects [1]. Antroquinonol can be used for the research of colon cancer [2]. Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-Antroquinonol. CAS No. 1010081-09-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19893. | |
| ANTS | ANTS is a fluorescent dye. ANTS and DPX are encapsulated in liposomes can be an effective approach for measuring membrane leakage [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 5398-34-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-D0789. | |
| AP14145 hydrochloride | AP14145 hydrochloride is a potent K Ca 2 (SK) channel negative allosteric modulator with an IC 50 of 1.1 μM for K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387505-59-9. Pack Sizes: 5 mg. Product ID: HY-120355A. | |
| AP-6 | AP-6 is a selective inhibitor of TMEM175 with activity in modulating lysosomal function. Acute inhibition of TMEM175 by AP-6 increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. AP-6 may be used in Parkinson's disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1369963-51-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161949. | |
| AP 811 | AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K i of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 124833-45-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1419. | |
| Apabetalone | Apabetalone (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. The IC 50 s are 87 μM and 0.51 μM for BD1 and BD2 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RVX-208; RVX000222. CAS No. 1044870-39-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16652. | |
| Apalutamide | Apalutamide (ARN-509) is a potent and competitive androgen receptor ( AR ) antagonist, binding AR with an IC 50 of 16 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARN-509. CAS No. 956104-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16060. | |
| Apatinib-d8 free base | Apatinib-d 8 (free base) is the deuterium labeled Apatinib free base[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: YN968D1-d8 free base. CAS No. 2468771-43-7. Pack Sizes: 1 mg. Product ID: HY-13342AS. | |
| Apatinib-d8 hydrochloride | Apatinib-d 8 (hydrochloride) is the deuterium labeled Apatinib hydrochloride[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 2468771-44-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-13342S. | |
| APC 366 | APC 366 is a selective inhibitor of mast cell tryptase ( K i =7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 158921-85-8. Pack Sizes: 5 mg. Product ID: HY-105999. | |
| Apelin-12 | Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 229961-08-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2537. | |
| Apelin-36(human) | Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC 50 of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC 50 =8.61). Apelin-36 has been linked to two major types of biological activities: cardiovascular and metabolic. Apelin-36(human) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ [1] [2] [3] [4]. Uses: Scientific research. Group: Peptides. CAS No. 252642-12-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1064. | |
| APF | APF is a fluorescence probe that can selectively, and dose dependently detect certain species among ROS and that are highly resistant to autoxidation. APF can be used in enzymatic and cellular systems [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 359010-70-1. Pack Sizes: 500 μg (11.81 mM * 100 μL in Methyl acetate). Product ID: HY-119977. | |
| APG-2449 | APG-2449 is an orally active ALK/ROS1/FAK inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2196186-84-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155163. | |
| Aphidicolin | Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola , inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 38966-21-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6733. | |
| APHS | APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 209125-28-0. Pack Sizes: 1 mg (38.11 mM * 100 μL in Methyl acetate); 5 mg (38.11 mM * 500 μL in Methyl acetate); 10 mg (38.11 mM * 1 mL in Methyl acetate). Product ID: HY-129284. | |
| Apicidin | Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 ( HDAC7/8 ) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: OSI 2040. CAS No. 183506-66-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6735. | |
| Apigenin | Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a K i of 2 μM. Uses: Scientific research. Group: Natural products. Alternative Names: 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1. CAS No. 520-36-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N1201. | |
| Apigenin 7-glucoside | Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin. CAS No. 578-74-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0578. | |
| AP-III-a4 | AP-III-a4 (ENOblock) is a nonsubstrate analogue enolase inhibitor with an IC 50 of 0.576 uM. AP-III-a4 can be used for the research of cancer and diabetic [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ENOblock. CAS No. 1177827-73-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15858. | |
| AP-III-a4 hydrochloride | AP-III-a4 (ENOblock) hydrochloride is a nonsubstrate analogue enolase inhibitor with an IC 50 of 0.576 uM. AP-III-a4 hydrochloride can be used for the research of cancer and diabetic [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ENOblock hydrochloride. CAS No. 2070014-95-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15858A. | |
| Apiin | Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC 50 = 0.08 mg/mL) in-vitro and iNOS expression (IC 50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells [1]. Uses: Scientific research. Group: Natural products. CAS No. 26544-34-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0577. | |
| Apilimod | Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC 50 s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively [1]. Apilimod is a potent and highly selective PIKfyve inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STA 5326; LAM-002A free base; AIT-101. CAS No. 541550-19-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14644. | |
| Apilimod mesylate | Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC 50 s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively [1]. Apilimod is a potent and highly selective PIKfyve inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STA 5326 mesylate; LAM-002A; AIT-101 mesylate. CAS No. 870087-36-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14644A. | |
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