BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Ganirelix Impurity C | Ganirelix Impurity C. Grade: > 95%. Molecular formula: C41H78N12O7. Mole weight: 851.16. |  |
| Ganirelix Impurity D | Ganirelix Impurity D. Synonyms: Mono-Acetyl- Ganilelix. Grade: > 95%. Molecular formula: C82H117ClN18O14. Mole weight: 1614.41. | |
| Ganirelix Impurity E | Ganirelix Impurity E. Synonyms: Di-Acetyl- Ganilelix. Grade: > 95%. Molecular formula: C84H121ClN18O15. Mole weight: 1658.47. | |
| Ganirelix Impurity F | Ganirelix Impurity F is an impurity of Ganirelix Acetate. Synonyms: AC-D-2-NAL-D-4-CLPHE-D-3-PAL; N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanine. Grade: > 95%. CAS No. 129225-22-5. Molecular formula: C32H31ClN4O5. Mole weight: 587.08. | |
| Ganitumab | Ganitumab is a human monoclonal antibody that targets IGF-1R. Ganitumab binds to and inhibits IGF-1R, which plays a key role in cell growth and proliferation. Ganitumab has been used in the research of cancer therapy. Synonyms: AMG 479; AMG-479; AMG479. Grade: 95%. CAS No. 905703-97-1. Molecular formula: C6472H10028N1728O2020S42. Mole weight: 145.7 kDa. | |
| Ganoderterpene A | Ganoderterpene A attenuates LPS-induced inflammation and apoptosis via suppressing MAPK and TLR-4/NF-κB pathways in BV-2 cells. CAS No. 2682180-85-2. Molecular formula: C31H46O7. Mole weight: 530.69. | |
| Ganstigmine hydrochloride | Ganstigmine hydrochloride is a selective inhibitor of AChE as a useful therapeutic drug for Alzheimer's disease patients with cognitive impairment accompanied by depression. Uses: Ache inhibitor. Synonyms: CHF 2819; CHF2819; CHF-2819; Ganstigmine hydrochloride; Ganstigmine HCl. Carbamic acid, (2-ethylphenyl)-, (1R,3aS,8aS)-1,2,3,3a,8,8a-hexahydro-1,3a-dimethyl-1-oxidopyrrolo(2,3-b)indol-5-yl ester, monohydrochloride; [(3R,3aS,8bS)-3,8b-dimethyl-3-oxido-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-3-ium-7-yl] N-(2-ethylphenyl)carbamate; hydrochloride. Grade: ≥98%. CAS No. 412044-92-9. Molecular formula: C21H26ClN3O3. Mole weight: 403.9. | |
| GANT58 | GANT 58 inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo. Synonyms: NSC 75503; GANT58; GANT-58; GANT 58; NSC-75503; NSC75503. Grade: 0.99. CAS No. 64048-12-0. Molecular formula: C24H16N4S. Mole weight: 392.47564. | |
| GANT-61 | GANT 61 is a GLI antagonist that inhibits GLI1 activation of gene expression with an IC50 value of 5 μM. Synonyms: GANT61; GANT-61; GANT 61; NSC 136476; NSC136476; NSC-136476; 2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline. Grade: >98%. CAS No. 500579-04-4. Molecular formula: C27H35N5. Mole weight: 429.612. | |
| Gantenerumab | Gantenerumab is a human monoclonal antibody targeting amyloid-β (Aβ). Gantenerumab was developed for the treatment of early symptomatic and asymptomatic Alzheimer's disease (AD). CAS No. 1043556-46-2. | |
| Garamine | Garamine is a remarkably potent compound extensively utilized in the research of diverse diseases such as cancer and autoimmune disorders. Synonyms: 2-Deoxy-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl]-D-streptamine. Grade: ≥ 98%. CAS No. 49751-51-1. Molecular formula: C13H27N3O6. Mole weight: 321.374. | |
| Garcimangosone D | Garcimangosone D, is a naturally occurring compound that is found in the Diospyros kaki leaves. The cytotoxic effects of this compound was tested against various animal cell lines (human A59 cell line, human HT-29 cell line and human Hep G2 cell line). Synonyms: [2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]phenyl-methanone. CAS No. 356055-68-0. Molecular formula: C19H20O9. Mole weight: 392.36. | |
| Garcinol | Garcinol is an inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 = 5 and 7 μM, respectively), which is isolated from Garcinia indica. It also inhibits the HAT GCN5 in Cryptococcus neoformans. Garcinol promotes expansion of human HSCs ex vivo. It induces apoptosis in some cancer cells thus can be used as a cancer therapy. Synonyms: Camboginol; (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione. Grade: ≥98% by HPLC. CAS No. 78824-30-3. Molecular formula: C38H50O6. Mole weight: 602.8. | |
| Gardiquimod | Gardiquimod is a small-molecule agonist of TLR7. It induces the activation of NF-κB in HEK 293 cells expressing TLR7. Uses: Toll-like receptor agonists. Synonyms: 1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-; 4-Amino-2-[(ethylamino)methyl]-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol; 1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol. Grade: ≥98% (HPLC). CAS No. 1020412-43-4. Molecular formula: C17H23N5O. Mole weight: 313.40. | |
| Gardiquimod hydrochloride | Gardiquimod hydrochloride is a toll-like receptor TLR7 agonist and immune response modulator with potent antitumor activity. It can activate antigen-presenting cells, including dendritic cells, and promote the activation of T cells and natural killer cells, making it a good candidate for vaccine adjuvant. Synonyms: 1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-, hydrochloride (1:1); 1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol hydrochloride. Grade: ≥95%. CAS No. 2956183-81-4. Molecular formula: C17H23N5O.HCl. Mole weight: 349.86. | |
| Garenoxacin | Garenoxacin, also called as BMS 284756, a new desfluoro(6)quinolone, is a topoisomerase II inhibitor with actibacterial activity to treat Gram-positive and Gram-negative bacterial infections. Uses: Des-f(6)-quinolone antibacterial; topoisomerase ii inhibitor. antibacterial. Synonyms: 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid BMS 284756 BMS-284756 BMS284756 garenoxacin. CAS No. 194804-75-6. Molecular formula: C23H20F2N2O4. Mole weight: 426.41. | |
| Garenoxacin mesylate | Garenoxacin mesylate is a novel oral des-fluoro quinolone with potent antimicrobial activity for the treatment of Gram-positive and Gram-negative bacterial infections. Synonyms: 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid; methanesulfonic acid; 1-cyclopropyl-8-(difluoromethoxy)-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate monohydrate; T 3811ME; BMS 284756; BM-284756; BMS284756; T-3811ME; T3811ME. Grade: >98%. CAS No. 223652-82-2. Molecular formula: C24H24F2N2O7S. Mole weight: 522.52. | |
| Garenoxacin Mesylate hydrate | Garenoxacin Mesylate hydrate is the Mesylate hydrate salt form of Garenoxacin. Garenoxacin, also called as BMS 284756, a new desfluoro(6)quinolone, is a topoisomerase II inhibitor with actibacterial activity to treat Gram-positive and Gram-negative bacter. Synonyms: 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid; methanesulfonic acid; hydrate BMS 284756 BMS-284756 BMS284756 garenoxacin. CAS No. 223652-90-2. Molecular formula: C24H26F2N2O8S. Mole weight: 540.53. | |
| Garomefrine hydrochloride | Garomefrine hydrochloride is a Alpha 1A adrenergic receptor agonist under the development of Nippon Shinyaku. Phase II clinical trials for the treatment of Stress incontinence and Urinary incontinence was discontinued in USD in 2001. Uses: Stress incontinence; urinary incontinence. Synonyms: NS 49; ABT 232; PNO 49B; ((R)-(-)-3'-(2-Amino-1-hydroxyethyl)-4'-fluoro-methanesulfonanilide hydrochloride. Grade: 98%. CAS No. 137431-04-0. Molecular formula: C9H14ClFN2O3S. Mole weight: 284.74. | |
| Garsorasib | Garsorasib is a potent inhibitor of KRAS G12C extracted from patent WO2020233592A1, compound 2. It has an IC50 of 10 nM. Synonyms: 4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-7-(2-amino-6-fluorophenyl)-1-(4,6-dicyclopropylpyrimidin-5-yl)-6-fluoropyrido(2,3-d)pyrimidin-2(1H)-one. CAS No. 2559761-14-5. Molecular formula: C32H32F2N8O2. Mole weight: 598.65. | |
| Gartisertib | Gartisertib is an orally available inhibitor of ataxia telangiectasia and Rad3 related (ATR) kinase, with potential antineoplastic activity. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and survival. Synonyms: ATR inhibitor 2; VX-803 (M4344); M-4344; 2-Amino-6-fluoro-N-[5-fluoro-4-(4-{[4-(3-oxetanyl)-1-piperazinyl]carbonyl}-1-piperidinyl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide. Grade: ≥95%. CAS No. 1613191-99-3. Molecular formula: C25H29F2N9O3. Mole weight: 541.55. | |
| Gastrazole | Gastrazole is a potent and selective antagonist of CCK2/gastrin receptor that reduces gastric acid levels. It inhibits gastrin-stimulated pancreatic cancer growth. Synonyms: JB95008; 1,3-Benzenedicarboxylic acid, 5-[[(2S)-2-[[[6-[[(cycloheptylmethyl)amino]carbonyl]-1H-benzimidazol-5-yl]carbonyl]amino]-3-(2-fluorophenyl)-1-oxopropyl]amino]-, sodium salt (1:2). Grade: 95%. CAS No. 862583-15-1. Molecular formula: C34H32FN5Na2O7. Mole weight: 687.63. | |
| Gastric Inhibitory Peptide (human) trifluoroacetate salt | Gastric inhibitory peptide (GIP) is a biologically active 42-amino acid peptide and it acts as a GIP receptor agonist that binds to rat recombinant GIP receptors expressed in CHO-K1 cells (IC50 = 3.2 nM) and increases cAMP accumulation (EC50 = 377 pM). Synonyms: GIP (human); Glucose-dependent Insulinotropic Peptide (human). Grade: ≥95%. Molecular formula: C226H338N60O66S·xCF3COOH. Mole weight: 4983.53. | |
| Gastrin/CCK antagonist 1 | An antagonist of gastrin/CCK. Synonyms: Urea, N-[1-cyclohexyl-2,3,4,5-tetrahydro-2,4-dioxo-5-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1H-1,5-benzodiazepin-3-yl]-N'-(4-fluorophenyl)-. CAS No. 162271-52-5. Molecular formula: C28H32FN5O4. Mole weight: 521.58. | |
| Gastrin-Releasing Peptide, human(TFA) | Gastrin-releasing peptide is a regulatory human peptide that elicits gastrin release and regulates gastric acid secretion and enteric motor function. Molecular formula: C132H205F3N38O33S2. Mole weight: 2973.40. | |
| GAT-100 | GAT-100, an indole derivative, has been found to be a negative allosteric modulator that could be used as a covalent probe in studying of the binding motifs of CB1R-allosteric ligand. Synonyms: GAT100; GAT-100; GAT 100; 3-ethyl-5-isothiocyanato-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide. Grade: 98%. CAS No. 1663564-42-8. Molecular formula: C25H28N4OS. Mole weight: 432.59. | |
| GAT107 | GAT107 is an allosteric agonist (EC50 value 28 μM) and positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptors (nAChR). GAT107 is the bioactive enantiomer of 4BP-TQS. It reverses nociception in mouse models of inflammatory and neuropathic pain. Synonyms: GAT107; GAT-107; GAT 107; (3aR,4S,9bS)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide. Grade: 99%. CAS No. 1476807-74-5. Molecular formula: C18H17BrN2O2S. Mole weight: 405.31. | |
| GAT211 | GAT211 is a positive allosteric modulator (PAM) and acts as a selective inhibitor of cannabinoid receptor 1 (CB1). It is a racemic mixture of GAT228 and GAT229. Uses: Cannabinoid receptor agonists. Synonyms: 3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole. Grade: ≥98%. CAS No. 102704-40-5. Molecular formula: C22H18N2O2. Mole weight: 342.39. | |
| GAT228 | GAT228 is the R-(+)-enantiomer of the CB1 positive allosteric modulator (PAM) GAT229 and a component of the racemic mixture GAT211. GAT228 is an allosteric agonist of cannabinoid receptor 1 (CB1). Synonyms: 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole. Grade: ≥98%. CAS No. 1446648-15-2. Molecular formula: C22H18N2O2. Mole weight: 342.39. | |
| GAT229 | GAT229 is the S-(-)-enantiomer of the CB1 positive allosteric modulator (PAM) GAT228 and a component of the racemic mixture GAT211. GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) which can't activate the receptor on its own but enhances the binding and activity of CB agonists. Uses: Cannabinoid receptor agonists. Synonyms: 3-[(1S)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole; S-(-)-3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole. Grade: ≥98%. CAS No. 889860-85-9. Molecular formula: C22H18N2O2. Mole weight: 342.39. | |
| GATA4-NKX2-5-IN-1 | GATA4-NKX2-5-IN-1 is a novel potent inhibitor of GATA4-NKX2-5 interaction, significantly reducing mechanical stretch induced hypertrophic growth reflected by an increase in cardiomyocyte cell size and ANP and BNP mRNA levels in response to mechanical stretch. Synonyms: GATA4-IN-3; 3i-1000; 3i 1000; 3i1000; N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide. CAS No. 544681-96-1. Molecular formula: C21H23N3O2. Mole weight: 349.43. | |
| Gatifloxacin-d4 HCl | An isotope labelled derivative of Gatifloxacin. Gatifloxacin is an antibiotic that inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Grade: 95% by HPLC; 98% atom D. Molecular formula: C19H18D4FN3O4.HCl. Mole weight: 415.88. | |
| Gatifloxacin Dimer 1 | Gatifloxacin Dimer 1 is an impurity of Gatifloxacin which is a new quinolone with antibacterial activity. Synonyms: 7-[4-(3-Carboxy-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-quinolyl)-3-methyl-piperazin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid. CAS No. 1497338-46-1. Molecular formula: C33H32F2N4O8. Mole weight: 650.63. | |
| Gatifloxacin Dimer 4 | Gatifloxacin Dimer 4 is an impurity of Gatifloxacin which is a new quinolone with antibacterial activity. Synonyms: 7-[2-[(3-Carboxy-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-quinolyl)amino]ethylamino]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid. CAS No. 1497338-53-0. Molecular formula: C30H28F2N4O8. Mole weight: 610.56. | |
| Gatifloxacin hydrochloride | Gatifloxacin (hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Synonyms: Gatifloxacin hydrochloride. Grade: >98%. CAS No. 121577-32-0. Molecular formula: C19H23ClFN3O4. Mole weight: 411.86. | |
| Gatifloxacin Impurity 1 | Gatifloxacin Impurity 1. Synonyms: N-Hydroxy Gatifloxacin; 1335198-95-2; CHEMBL1818724. Grade: > 95%. CAS No. 1335198-95-2. Molecular formula: C19H22FN3O5. Mole weight: 391.40. | |
| Gatifloxacin N-Oxide | Gatifloxacin N-Oxide is an impurity of Gatifloxacin. Grade: > 95%. CAS No. 1798008-43-1. Molecular formula: C19H22FN3O5. Mole weight: 391.40. | |
| Gatifloxacin USP Related Compound E | Iso-Gatifloxacin, an antibiotic of the fluoroquinolone class, exhibits potent activity against a wide range of bacterial infections. It stands as a crucial weapon against susceptible strains of Gram-positive and Gram-negative bacteria. Synonyms: Iso-Gatifloxacin; Isogatifloxacin; 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(2-Methyl-1-piperazinyl)-4-oxo-. Grade: 95%. CAS No. 1029364-65-5. Molecular formula: C19H22FN3O4. Mole weight: 375.40. | |
| Gavestinel | Gavestinel is a non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM), displaying >1000-fold selectivity over NMDA, AMPA, and kainate binding sites. Gavestinel exhibits a neuroprotective property in animal models of ischaemic stroke. Uses: Glycine agents. Synonyms: 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[3-oxo-3-(phenylamino)-1-propenyl]-, (E)-; 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-1H-indole-2-carboxylic acid; GV 150526; GV 150526X; (E)-4,6-dichloro-3-(3-oxo-3-(phenylamino)prop-1-en-1-yl)-1H-indole-2-carboxylic acid. Grade: ≥95%. CAS No. 153436-22-7. Molecular formula: C18H12Cl2N2O3. Mole weight: 375.21. | |
| Gavestinel sodium salt | Gavestinel is a non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM), displaying > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Gavestinel exhibits a neuroprotective property in animal models of ischaemic stroke. Synonyms: 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-, sodium salt (1:1); 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-, monosodium salt; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[3-oxo-3-(phenylamino)-1-propenyl]-, monosodium salt, (E)-; GV 150526A. Grade: ≥98% by HPLC. CAS No. 153436-38-5. Molecular formula: C18H11Cl2N2O3Na. Mole weight: 397.19. | |
| Gaxilose | Gaxilose is a synthetic disaccharide and a substrate of intestinal lactase. It can be applicated in a new noninvasive diagnostic test based on urine or serum measurement of D-xylose after lactase cleavage of orally administered gaxilose. Uses: Used in a new noninvasive diagnostic test based on urine or serum measurement of d-xylose after lactase cleavage of orally administered 4-galactosylxylose. Synonyms: 4-O-Galactosyl-D-xylose; 4-O-Galactosylxylose; 4-Galactosylxylose; Gaxilose; (3R,4R,5R)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol. Grade: 98%. CAS No. 14087-31-1. Molecular formula: C11H20O10. Mole weight: 312.27. | |
| GB-110 hydrochloride | GB-110 hydrochloride is a potent, and nonpeptidic protease activated receptor 2 (PAR2) agonist. It selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. Grade: 99%. Molecular formula: C33H49ClN6O5. Mole weight: 645.23. | |
| GB 83 | GB 83 is a selective antagonist of human protease activated receptor 2 (PAR2) (IC50 = 2 mM). Synonyms: GB83; GB 83; GB-83; N-((S)-3-Cyclohexyl-1-((2S,3S)-1-(2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)-3-methyl-1-oxopentan-2-ylamino)-1-oxopropan-2-yl)isoxazole-5-carboxamide. Grade: 99%. CAS No. 1252806-86-2. Molecular formula: C32H44N4O4. Mole weight: 548.72. | |
| Gboxin | Gboxin is an oxidative phosphorylation inhibitor in cancer cells, which inhibits the activity of F0F1 ATP synthase. Synonyms: 2-ethyl-1-methyl-3-[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-2-oxoethyl]-1H-benzimidazolium, monochloride. Grade: ≥98%. CAS No. 2101315-36-8. Molecular formula: C22H33N2O2·Cl. Mole weight: 392.96. | |
| GBR 12783 | GBR 12783, a specific, potent and selective dopamine uptake inhibitor, inhibits the [3H]-dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. It can improve memory performance and increase hippocampal acetylcholine release in rats. Synonyms: Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-; 1-(2-(Diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine; 1-(2-(Benzhydryloxy)ethyl)-4-cinnamylpiperazine; 1-[2-(Diphenylmethoxy)ethyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine. Grade: ≥95%. CAS No. 67469-57-2. Molecular formula: C28H32N2O. Mole weight: 412.57. | |
| GBR 12783 dihydrochloride | GBR 12783 dihydrochloride is a potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM). Synonyms: GBR 12783 dihydrochloride; GBR12783 dihydrochloride; GBR-12783 dihydrochloride; 1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride. Grade: ≥99% by HPLC. CAS No. 67469-75-4. Molecular formula: C28H32N2O.2HCl. Mole weight: 485.5. | |
| GBR-12935 | GBR 12935 is a piperazine derivative and a potent and selective inhibitor of dopamine uptake with IC50 value of 3.7nM. It is found to have multiple binding sites in rat and human brains. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. It(1-9 nM) dose-dependently inhibited active uptake of [3H]dopamine in homogenates of the nucleus accumbens and could inhibit DA uptake with IC50 value of 3.7nM in vitro. It elevated locomotion to a greater extent in C57BL/6J mice at the maximally active dose of 10 mg/kg in vivo. It shows a Kd value of 1.08nM in dopamine transporter transfected COS-7 cells. It is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain. Uses: Gbr 12935 inhibits da uptake with ic50 value of 3.7nm in vitro. it elevated locomotion to a greater extent in c57bl/6j mice at the maximally active dose of 10 mg/kg in vivo. it shows a kd value of 1.08nm in dopamine transporter transfected cos-7 cells. Synonyms: GBR-12935; GBR 12935; GBR12935; 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine; 1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine; Piperazine, 1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl)-; N-[3-tert-Butyl-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N-[4-[2-(4-Morpholinyl)ethoxy]naphthalen-1-yl]urea; 1-(2-(Benzhydryloxy)e | |
| GBR-12935 dihydrochloride | GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor. Synonyms: GBR12935 dihydrochloride; GBR-12935 dihydrochloride. Grade: 0.99. CAS No. 67469-81-2. Molecular formula: C28H36Cl2N2O. Mole weight: 487.509. | |
| GBR 13069 dihydrochloride | GBR 13069 dihydrochloride is a potent and selecticve inhibitor of dopamine uptake (IC50 = 40 nM). Synonyms: GBR 13069 dihydrochloride; GBR13069 dihydrochloride; GBR-13069 dihydrochloride; (1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride. CAS No. 67469-45-8. Molecular formula: C28H30F2N2O.2HCl. Mole weight: 521.48. | |
| GBT-440 | GBT-440 is a substituted benzaldehyde compound that can modulate sickle hemoglobin (HbS) for treatment of disorders. Uses: Hematologic agents. Synonyms: Voxelotor, GBT-440, GBT 440, GBT440, GTx-011, GTx011, GTx 011; 2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)pyridin-3-yl]methoxy]benzaldehyde; Hemoglobin Modulators-1. Grade: >98%. CAS No. 1446321-46-5. Molecular formula: C19H19N3O3. Mole weight: 337.37. | |
| GBT 440 hydrochloride | GBT 440 hydrochloride is an oral medication used to treat sickle cell disease in patients aged 12 and older. It functions by increasing hemoglobin's affinity for oxygen, which helps prevent red blood cell sickling and reduces associated complications. GBT 440 hydrochloride is a hemoglobin S (HbS) polymerization inhibitor. It binds to hemoglobin, stabilizing the hemoglobin molecule in its oxygenated form. This prevents the sickling of red blood cells and reduces the associated hemolysis and vaso-occlusive events. Synonyms: 2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde hydrochloride (1:1); Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-, hydrochloride (1:1); 2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde hydrochloride; GBT-440 hydrochloride; GBT440 hydrochloride; Voxelotor hydrochloride; Oxbryta hydrochloride; Hemoglobin Modulators-1 hydrochloride. Grade: ≥95%. CAS No. 1667717-41-0. Molecular formula: C19H20ClN3O3. Mole weight: 373.84. | |
| GC 14 | GC 14 is a selective antagonist of thyroid hormone receptor (THR), with IC50s of 35 and 200 nM for hTRβ and hTRα, respectively. Synonyms: Thyromimetic, 5a; {4-[(6-Hydroxy-5-isopropyl-4'-nitro-3-biphenylyl)methyl]-3,5-dimethylphenoxy}acetic acid; Acetic acid, 2-[4-[[6-hydroxy-5-(1-methylethyl)-4'-nitro[1,1'-biphenyl]-3-yl]methyl]-3,5-dimethylphenoxy]-. Grade: ≥95%. CAS No. 447415-34-1. Molecular formula: C26H27NO6. Mole weight: 449.50. | |
| GC376 sodium | GC376 is a 3CLpro inhibitor which is previously reported to be active against the 3CLpro of multiple coronaviruses, including SARS-CoV, but with highest potency against FIPV in cell culture. GC376 inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM. Synonyms: GC376 sodium; GC 376 sodium; GC-376 sodium; (2S)-1-hydroxy-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate sodium. Grade: ≥98% (HPLC). CAS No. 1416992-39-6. Molecular formula: C21H30N3NaO8S. Mole weight: 507.53. | |
| GC7 Sulfate | GC7 Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). Synonyms: N1-guanyl-1,7-diaminoheptane Sulfate; GC 7 Sulfate; GC-7 Sulfate. CAS No. 150417-90-6. Molecular formula: C8H22N4O4S. Mole weight: 270.35. | |
| GCN2iB | GCN2iB is an ATP-competitive inhibitor of serine/threonine-protein kinase general control nonderepressible 2 (GCN2) with IC50 of 2.4 nM. Synonyms: N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide. CAS No. 2183470-12-2. Molecular formula: C18H12ClF2N5O3S. Mole weight: 451.83. | |
| GCN2-IN-6 | GCN2-IN-6 is a potent and orally available inhibitor of GCN2 confirmed by in-house enzymatic (IC50 = 1.8 nM) and cellular assays (IC50 = 9.3 nM). It is also an eIF2α kinase PERK inhibitor with IC50s of 0.26 nM and 230 nM in enzymatic assay and in cells, respectively. Synonyms: Benzenesulfonamide, N-[3-[2-(2-amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-2,5-dichloro-3-(hydroxymethyl)-; N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-2,5-dichloro-3-(hydroxymethyl)benzene-1-sulfonamide. Grade: ≥97%. CAS No. 2183470-09-7. Molecular formula: C19H12Cl2F2N4O3S. Mole weight: 485.29. | |
| GD1b-Ganglioside | GD1b-Ganglioside is a pivotal biomolecule, finding widespread application for the comprehensive investigation and comprehension of diverse neurodegenerative ailments, including Parkinson's disease is alzheimer's disease and Multiple Sclerosis. Synonyms: Ganglioside GD1b; Ganglioside C1; Ganglioside G2; Ganglioside G2 (hexasaccharide); Ganglioside GIII; GD1b; GD1b ganglioside. CAS No. 19553-76-5. Molecular formula: C80H144N4O37. Mole weight: 1754. | |
| GD1b-Oligosaccharide | GD1b-Oligosaccharide is a crucial component widely used in the research of neurological diseases, including Alzheimer's and Parkinson's. With its bioactive properties, GD1b-Oligosaccharide holds promise for targeted drug delivery systems, disease diagnostics and advanced research in neurobiology. Synonyms: Galb1-3GalNAcb1-4(Neu5Aca2-8Neu5Aca2-3)Galb1-4Glc. Molecular formula: C48H77N3O37Na2. Mole weight: 1334.10. | |
| GD2-Ganglioside | GD2-Ganglioside is a complex lipid molecule extensively present within the neuroblastoma tumours cells. This molecule is the focal point of numerous immunotherapies such as chimeric antigen receptor (CAR) T-cell therapy and monoclonal antibodies and has the ability to specifically recognize and demolish GD2-Ganglioside expressing cancer cells. Synonyms: Ganglioside GD2; Disialoganglioside-GD2; Disialoganglioside GD2; GD2. CAS No. 65988-71-8. | |
| GD2-Oligosaccharide | GD2-Oligosaccharide is a biomedical product used in the research of neuroblastoma. It has been found to target the GD2 antigen present on neuroblastoma cells. Synonyms: GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc. Molecular formula: C42H67N3O32Na2. Mole weight: 1171.96. | |
| GD2-Oligosaccharide-b-(N-acetyl-propargyl) | GD2-Oligosaccharide-b-(N-acetyl-propargyl) is a remarkable biomedical compound, emerging as a formidable compound in the research of neuroblastoma, an affliction predominantly encountered during early stages of life. Synonyms: GD2-Saccharide-b-NAc-propargyl. Molecular formula: C47H72N4O32Na2. Mole weight: 1251.06. | |
| GD3-Ganglioside | GD3-Ganglioside, a glycosphingolipid, is an intricate modulator of cell growth, differentiation and apoptosis. Anti-cancer therapies utilizing GD3-Ganglioside as a therapeutic target have shown significant promise, making it a distinguished focus of research in the realm of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In addition to the fascinating roles delineated above, GD3-Ganglioside has been extensively studied for its potential as an antiviral agent owing to its involvement in the immune response. Synonyms: Ganglioside GD3; Disialohematoside; Disialohematoside GD3; Disialosyllactosylceramide; Ganglioside D3; GD3. CAS No. 62010-37-1. | |
| GDC-0068 dihydrochloride | Testing against a broad panel of 230 kinases, GDC-0068 only inhibits 3 kinases by >70% at 1 μM concentration (PRKG1α, PRKG1β, and p70S6K, with IC50 of 98 nM, 69 nM, and 860 nM, respectively). GDC-0068 displays >100-fold selectivity for Akt over PKA with IC50 of 3.1 μM. In LNCaP, PC3 and BT474M1 cells, GDC-0068 treatment inhibits the phosphorylation of the Akt substrate, PRAS40 with IC50 of 157 nM, 197 nM, and 208 nM, respectively. Furthermore, GDC-0068 selectively inhibits cell cycle progression and viability of cancer cell lines driven by Akt signaling, including those with defects in the tumor suppressor PTEN, oncogenic mutations in PIK3CA, and amplification of HER2, with strongest effects in HER2+ and Luminal subtypes. Oral administration of GDC-0068 in PC3 prostate tumor xenografts model induces down-regulation of p-PRAS40. In BT474-Tr xenografts, GDC-0068 treatment reduces pS6 and peIF4G levels, re-localizes FOXO3a to nucleus, and induces feedback upregulation of HER3 and pERK. Administration of GDC-0068 exhibits potent antitumor efficacy in multiple xenograft tumor models, including the PTEN-deficient prostate cancer models LNCaP and PC3, the PIK3CA H1047R mutant breast cancer model KPL-4, and MCF7-neo/HER2 tumor model. Synonyms: Ipatasertib dihydrochloride; RG-7440 dihydrochloride; GDC-0068 dihydrochloride; RG 7440 dihydrochloride; GDC 0068 dihydrochloride; RG7440 dihydrochloride; GDC0068 | |
| GDC-0077 | GDC-0077 is an orally available and selective PI3K inhibitor (IC50 = 0.038 + 0.003 nM) with > 300-fold selective over other Class I PI3K isoforms. GDC-0077 exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Synonyms: GDC 0077; GDC0077; Inavolisib. CAS No. 2060571-02-8. Molecular formula: C18H19F2N5O4. Mole weight: 407.37. | |
| GDC-0084 | GDC-0084, a PI3K inhibitor, has been found to have probable antineoplastic effect and could pass blood-brain barrier with favourable penetration. It was just licensed to Novogen and start a Phase II trial for Glioma. Uses: Gdc-0084 is a pi3k inhibitor that has been found to have probable antineoplastic effect and could pass blood-brain barrier with favourable penetration. Synonyms: RG7666; RG-7666; RG 7666; GDC-0084; GDC0084; GDC 0084; 5-(6,6-dimethyl-4-morpholin-4-yl-8,9-dihydropurino[8,9-c][1,4]oxazin-2-yl)pyrimidin-2-amine. Grade: 98%. CAS No. 1382979-44-3. Molecular formula: C18H22N8O2. Mole weight: 382.19. | |
| GDC-0152 | GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Synonyms: GDC-0152; GDC0152; GDC 0152. CAS No. 873652-48-3. Molecular formula: C25H34N6O3S. Mole weight: 498.646. | |
| GDC-0214 | GDC-0214 is a highly potent, selective and inhalable Janus kinase-1 (JAK-1) inhibitor. Synonyms: GDC 0214; GDC0214; iJak-381; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(5-chloro-2-difluoromethoxy-phenyl)-1-(2-{4-[(2-cyano-ethyl)-methyl-amino]-piperidin-1-yl}-2-oxo-ethyl)-1H-pyrazol-4-yl]-amide. CAS No. 1831144-46-7. Molecular formula: C28H28ClF2N9O3. Mole weight: 612.04. | |
| GDC-0310 | Nav1.7 is an extensively investigated target for pain. GDC-0310 is a selective Nav1.7 inhibitor. Synonyms: UNII-72GO7NL642; GDC 0310. CAS No. 1788063-52-4. Molecular formula: C25H29Cl2FN2O4S. Mole weight: 543.48. | |
| GDC-0326 | GDC-0326 is a selective PI3Kα (α-Isoform of Phosphoinositide 3-Kinase) inhibitor. GDC-0326 is highly selective over other kinases. It has low plasma CL in human. In PI3 kinase family, there are four class I PI3K isoforms including α, β, δ, and γ and PI3Kα is the most commonly associated with cancers, so GDC-0326 may become a drug candidate for cancer treatment. Uses: Anti-cancer. Synonyms: GDC-0326; GDC 0326; GDC0326; (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide. Grade: 98%. CAS No. 1282514-88-8. Molecular formula: C19H22N6O3. Mole weight: 382.42. | |
| GDC-0334 | GDC-0334, a TRPA1 antagonist, is used for the treatment of TRPA1-mediated diseases, such as pain or asthma. Synonyms: (4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide; 2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)-. Grade: ≥90%. CAS No. 1984824-54-5. Molecular formula: C24H19F8N5O3S. Mole weight: 609.49. | |
Our database is helping our users find suppliers everyday.
