BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Gestodene Dimer | Gestodene Dimer is a promising biomedical breakthrough, used in studying hormone-related disorders and malignancies. Synonyms: (8R,8'R,9S,9'S,10R,10'R,13S,13'S,14S,14'S,17S,17'S)-17,17'-(Ethyne-1,2-diyl)bis(13-ethyl-17-hydroxy-6,7,8,9,10,11,12,13,14,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one). Grade: > 95%. Molecular formula: C40H50O4. Mole weight: 594.84. |  |
| Gestodene EP Impurity K | An impurity of Gestodene. Gestodene is a synthetic progestogen commonly used in combination oral contraceptives, often paired with ethinyl estradiol to enhance contraceptive efficacy. It works by inhibiting ovulation and altering the uterine lining to prevent implantation of a fertilized egg. Synonyms: Aromatic 6-Keto Gestodene; 13-Ethyl-3,17-dihydroxy-18,19-dinor-17α-pregna1,3,5(10),15-tetraen-20-yn-6-one; Aromatic 6-keto-gestodene; (17α)-13-Ethyl-3,17-dihydroxy-18,19-dinorpregna-1,3,5(10),15-tetraen-20-yn-6-one; (8R,9S,13S,14S,17R)-13-Ethyl-17-ethynyl-3,17-dihydroxy-7,8,9,11,12,13,14,17-octahydro-6H-cyclopenta[a]phenanthren-6-one; Gestodene Impurity K. Grade: ≥95%. CAS No. 1421283-61-5. Molecular formula: C21H22O3. Mole weight: 322.40. | |
| Gestodene Impurity A | An impurity of Gestodene, which is a synthetic progesterone used primarily in female contraceptives and menopausal hormone therapy. Synonyms: (8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,8,9,10,11,12,13,14,17-decahydro-3H-cyclopenta[a]phenanthren-3-one; 6,7-Dehydro Gestodene; Delta6-Gestodene; Gestodene EP Impurity A; Delta-6-Gestodene. Grade: ≥95%. Molecular formula: C21H24O2. Mole weight: 308.42. | |
| Gestodene Impurity B | Gestodene Impurity B. Grade: > 95%. Molecular formula: C21H26O2. Mole weight: 310.44. | |
| Gestodene Impurity C | Gestodene Impurity C. Grade: > 95%. Molecular formula: C24H32O3. Mole weight: 368.52. | |
| Gestodene Impurity D | An impurity of Gestodene, which is a synthetic progesterone used primarily in female contraceptives and menopausal hormone therapy. Synonyms: 6β-Hydroxy Gestodene; 6Beta-Hydroxy Gestodene; 13-Ethyl-6beta,17-dihydroxy-18,19-dinor-17alpha-pregna-4,15-dien-20-yn-3-one; (6R,8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-6,17-dihydroxy-1,2,6,7,8,9,10,11,12,13,14,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; Gestodene EP Impurity D. Grade: ≥95%. Molecular formula: C21H26O3. Mole weight: 326.44. | |
| Gestodene Impurity E | An impurity of Gestodene, which is a synthetic progesterone used primarily in female contraceptives and menopausal hormone therapy. Synonyms: (8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,7,8,9,10,11,12,13,14,17-decahydro-3H-cyclopenta[a]phenanthrene-3,6(2H)-dione; 6-Keto-gestodene; 6β-Keto-gestodene; Gestodene EP Impurity E; 13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregna-4,15-dien-20-yne-3,6-dione; 6-Keto Gestodene. Grade: ≥95%. CAS No. 2143949-52-2. Molecular formula: C21H24O3. Mole weight: 324.42. | |
| Gestodene Impurity F | Gestodene Impurity F. Synonyms: 15-alfa-acetoxy Gestodene. Grade: > 95%. Molecular formula: C23H30O4. Mole weight: 370.49. | |
| Gestodene Impurity H | Gestodene Impurity H. Synonyms: Diethynyl-gestodene; (8R,9S,10R,13S,14S,17R)-13-Ethyl-3,17-diethynyl-2,7,8,9,10,11,12,13,14,17-decahydro-1H-cyclopenta[a]phenanthren-17-ol. Grade: > 95%. Molecular formula: C23H26O. Mole weight: 318.46. | |
| Gestodene Impurity I | An impurity of Gestodene, which is a synthetic progesterone used primarily in female contraceptives and menopausal hormone therapy. Synonyms: 4,5-Dihydro-5alpha-Methoxygestodene; (4,5-Dihydro-5alpha-methoxy) Gestodene; 18,19-Dinorpregn-15-en-20-yn-3-one, 13-ethyl-17-hydroxy-5-methoxy-, (5α,17α)-; (5R,8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-5-methoxy-1,2,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one; (5α,17α)-13-Ethyl-17-hydroxy-5-methoxy-18,19-Dinorpregn-15-en-20-yn-3-one; Gestodene impurity I; 5-Methoxy gestodene; 13-Ethyl-17-hydroxy-5-methoxy-18,19-dinor-5α,17α-pregn-15-en-20-yn-3-one. Grade: ≥95%. CAS No. 2948318-72-5. Molecular formula: C22H30O3. Mole weight: 342.48. | |
| Gestodene Impurity L | Gestodene Impurity L. Grade: > 95%. Molecular formula: C21H26O2. Mole weight: 310.44. | |
| Gestodene Ketal | Gestodene Ketal. Synonyms: 18,19-Dinorpregna-5,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, cyclic 1,2-ethanediyl acetal, (17α)-; 13-Ethylspiro(18,19-dinor-17α-pregna-5,15-dien-20-yne-3,2'-[1,3]dioxolan)-17-ol and 13-ethylspiro(18,19-dinor-17α-pregna-5(10),15-dien-20-yne-3,2'-[1,3]dioxolan)-17-ol; Gestodene ketal; Gestodene EP Impurity J; (8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-1,2,4,7,8,9,10,11,12,13,14,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-ol. Grade: ≥95%. CAS No. 104933-99-5. Molecular formula: C23H30O3. Mole weight: 354.48. | |
| Gestodene sulfate | Gestodene sulfate, a synthetic progestogen extensively utilized in the biomedical sector, used in studying the regulation of the menstrual cycle, research of dysmenorrhea symptoms, and efficacious prevention of undesired pregnancies. Grade: > 95%. Molecular formula: C21H26O5S. Mole weight: 390.50. | |
| Gestonorone Caproate | Gestonorone Capronate, is a pro-drug of Gestonorone, which is a steroidal progestin. It is used in the treatment of benign prostatic hypertrophy (BPH) and endometrial cancer. It is also an inhibitor of the reductive pathway of Testosterone metabolism. Synonyms: Primostat; Gestronol hexanoate; 17-Hydroxy-19-norpregn-4-ene-3,20-dione hexanoate; 17-[(1-Oxohexyl)oxy]-19-norpregn-4-ene-3,20-dione; 17α-Hydroxy-19-norprogesterone Caproate; 17β-Acetyl-17-hydroxyestr-4-ene-3-one Hexanoate; 19-Nor-17α-caproyloxy-4-pregnene-3,20. Grade: > 95%. CAS No. 1253-28-7. Molecular formula: C26H38O4. Mole weight: 414.59. | |
| Gestrinone Impurity 1 | Gestrinone Impurity 1. Grade: > 95%. Molecular formula: C20H26O2. Mole weight: 298.43. | |
| Gestrinone Impurity 2 | Gestrinone Impurity 2. Grade: > 95%. Molecular formula: C19H28O2. Mole weight: 288.43. | |
| Gestrinone Impurity 3 | Gestrinone Impurity 3. Grade: > 95%. Molecular formula: C22H28O2. Mole weight: 324.47. | |
| Gestrinone Impurity 4 | Gestrinone Impurity 4. Grade: > 95%. Molecular formula: C19H26O2. Mole weight: 286.42. | |
| Gestrinone Impurity 6 | Gestrinone Impurity 6. Grade: > 95%. Molecular formula: C21H26O2. Mole weight: 310.44. | |
| Gestrinone Impurity 7 | Gestrinone Impurity 7. Grade: > 95%. Molecular formula: C21H28O2. Mole weight: 312.46. | |
| Gestrinone Impurity 8 | Gestrinone Impurity 8. Synonyms: (7a,17a)-17-Hydroxy-7-methyl-19-norpregn-4-en-20-yn-3-one; 17a-Ethynyl-17-hydroxy-7a-methyl-4-estren-3-one; 7a-Methylnorethindrone; NSC 142228; Org-OM 38; 7α-Methyl-17β-hydroxy-17-ethynylestra-4-ene-3-one. Grade: > 95%. CAS No. 1162-60-3. Molecular formula: C21H28O2. Mole weight: 312.46. | |
| Gevokizumab | Gevokizumab is a monoclonal antibody targeting interleukin 1β (IL-1β), which is a pro-inflammatory cytokine. Gevokizumab has been used in the research of type 2 diabetes mellitus, scleritis and various cancers. CAS No. 1129435-60-4. | |
| GF-109203X | GF-109203X is a potent and highly selective PCK inhibitor, which inhibits PKC isozymes alpha, beta 1, beta 2, gamma, delta and epsilon in vitro. GF-109203X inhibited GSK-3 in vitro, when assayed either in cell lysates (IC(50) 360 nM or in GSK-3beta immunoprecipitates (IC(50) 170 nM derived from rat epididymal adipocytes. Pretreatment of adipocytes with GF-109203X (5 microM) reduced GSK-3 activity in total cell lysates, to 25.1+/-4.3% of control. Synonyms: GF109203X; GF 109203X; Bisindolylmaleimide i; GO 6850; GO-6850; GO6850; 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide. Grade: ≥98%. CAS No. 133052-90-1. Molecular formula: C25H24N4O2. Mole weight: 412.49. | |
| GFB-8438 | GFB-8438 is a potent and subtype selective TRPC5 inhibitor with IC50 of 0.18 and 0.29 μM for hTRPC5 and hTRPC4, respectively. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate (PS) in vitro. CAS No. 2304549-73-1. Molecular formula: C16H14ClF3N4O2. Mole weight: 386.76. | |
| GGsTop | GGsTop is a selective and irreversible γ-glutamyl transpeptidase (GGT) inhibitor that inhibits GGT activation and blocks oxidative stress. Study shows that GGsTop pevents ischemia/reperfusion-induced acute kidney injury in rats. Synonyms: GGsTop; GGs-Top; GGs Top; 3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneacetic acid; 2-amino-4-[[3-(carboxymethyl)phenoxy]-methoxyphosphoryl]butanoic acid. Grade: ≥95% by HPLC. CAS No. 926281-37-0. Molecular formula: C13H18NO7P. Mole weight: 331.26. | |
| GGTI 2133 trifluoroacetate salt | GGTI 2133 is a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I) with an IC50 value of 38 nM, whch is 140-fold selective for GGTase I over farnesyltransferase (IC50 = 5,400 nM). Synonyms: N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-L-leucine, 2,2,2-trifluoroacetate salt. Grade: ≥95%. CAS No. 1217480-14-2. Molecular formula: C27H28N4O3·xCF3COOH. Mole weight: 456.54. | |
| GGTI-2154 | GGTI-2154 is a geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2154 results not only in halting the growth of aggressive breast tumors but actually in inducing the regression (54 +/- 3%) of all 19 tumors analyzed. The farnesyltransferase (FTase) inhibitor FTI-2148 induced an average of 87 +/- 3% regression in the 13 tumors analyzed. GGTase I, but not FTase, is inhibited in breast tumors after treatment with GGTI-2154, whereas in tumors from mice treated with FTI-2148, only FTase is inhibited. The processing of the geranylgeranylated proteins RhoA, Rap1, and R-Ras, but not the farnesylated proteins H-Ras and HDJ-2, is inhibited in tumors obtained from mice treated with GGTI-2154. GGTI-2154 and FTI-2148 suppress constitutively activated phospho-Erk1/2 and phospho-Akt, induce apoptosis, and induce differentiation toward ductolobular breast epithelium. Synonyms: GGTI-2154; GGTI 2154; GGTI2154. Grade: 98%. CAS No. 251577-10-3. Molecular formula: C24H28N4O3. Mole weight: 420.51. | |
| GGTI-2154 hydrochloride | GGTI-2154 hydrochloride is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. It shows more than 200-fold selectivity for GGTase I over FTase (IC50 = 5600 nM). Grade: 98%. CAS No. 478908-50-8. Molecular formula: C24H29ClN4O3. Mole weight: 456.97. | |
| GGTI-2166 | GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells. Synonyms: GGTI2166; GGTI2166. Grade: 98%. CAS No. 478908-51-9. Molecular formula: C25H30N4O3. Mole weight: 434.53. | |
| GGTI-2418 | GGTI-2418 is a synthetic peptidomimetic inhibitor of geranylgeranyltransferase I (GGTase I) that appears to induce apoptosis by downregulating several pivotal oncogenic and tumor survival pathways. GGTase I catalyzes the lipid posttranslational modification which is required for the function of Rho GTPases (frequently found aberrantly activated in human cancer). GGTase I inhibitors block Rho function in cancer cells and induce a G1 phase cell cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation of PI3K/Akt. Synonyms: GGTI 2418; GGTI-2418; GGTI 2418. CAS No. 501010-06-6. Molecular formula: C23H31N5O4. Mole weight: 441.532. | |
| GGTI-286 | GGTI 286 is a cell permeable and potent inhibitor of geranylgeranyltransferase I (GGTase I) that selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 and >30 μM, respectively). Synonyms: Methyl (5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-carbonyl)-L-leucinate. CAS No. 171744-11-9. Molecular formula: C23H31N3O3S. Mole weight: 429.57. | |
| GGTI 286 trifluoroacetate salt | GGTI 286 is a cell permeable and potent inhibitor of geranylgeranyltransferase I (GGTase I) that selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 and >30 μM, respectively). Synonyms: N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-L-leucine, methyl ester, trifluoroacetate salt. Grade: ≥90%. Molecular formula: C23H31N3O3S·2CF3COOH. Mole weight: 657.62. | |
| GGTI-297 | GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase). Synonyms: GGTI297; GGTI 297. Grade: 98%. CAS No. 181045-83-0. Molecular formula: C26H31N3O3S. Mole weight: 465.61. | |
| GGTI-298 | GGTI-298 is a selective geranylgeranyltransferase type I inhibitor that displays little effect on other prenylation enzymes such as farnesyltransferase. GGTI-298 causes G0-G1 cell cycle block and apoptosis in A549 cells (IC50 = 10 μM for A549 cells) and inhibits cell invasion and migration in COLO 320CM cells. Synonyms: methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-naphthalen-1-ylbenzoyl]amino]-4-methylpentanoate; GGTI 298; GGTI298; GGTI-298; N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA; (S)-methyl 2-(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate. CAS No. 180977-44-0. Molecular formula: C27H33N3O3S. Mole weight: 479.63. | |
| GGTI 298 (trifluoroacetate salt) | GGTI-298 is a selective geranylgeranyltransferase type I inhibitor that displays little effect on other prenylation enzymes such as farnesyltransferase. GGTI-298 causes G0-G1 cell cycle block and apoptosis in A549 cells (IC50 = 10 μM for A549 cells) and inhibits cell invasion and migration in COLO 320CM cells. Synonyms: methyl (4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzoyl)-L-leucinate 2,2,2-trifluoroacetate; GGTI-298 TFA; GGTI-298 trifluoride salt; GGTI-298; GGTI 298; GGTI298. CAS No. 1217457-86-7. Molecular formula: C27H33N3O3S.CF3COOH. Mole weight: 593.7. | |
| Ghatti gum | Gum Ghatti is an exudate from the tree Anogeissus latifolia found in India and Sri Lanka. Applications in the food and pharmaceutical industries are similar to gum Arabic, where it is used as an emulsifier. The polysaccharide has a backbone chain of (1-6)-linked β-D-galactopyranosyl units with some (1-4)-D-glucopyranosyluronic acid units, some joining (1-2)-D-mannopyranosyl units, and some L-arabinofuranose units. Synonyms: Gum ghatti; Anogeissus gum; Brix 12; Dhavda gum; Dhow gum; Gatifolia RD; Gatifolia SD; Ghatti; Ghatti gum SD; Gum Ghatti SD; Gums, ghatti; Indian gum. CAS No. 9000-28-6. | |
| Ghrelin receptor full agonist-2 | Ghrelin receptor full agonist-2 is a highly potent Ghrelin receptor full agonist. Synonyms: 5-(2-chlorophenyl)-N-((3R,4S)-1-(phenylsulfonyl)-4-(((S)-piperidin-3-yl)carbamoyl)pyrrolidin-3-yl)isoxazole-3-carboxamide. CAS No. 2602452-73-1. Molecular formula: C26H28ClN5O5S. Mole weight: 558.05. | |
| GI 181771 | GI-181771X is a novel effect of oral CCK-1 agonist on fasting and postprandial gastric functions in healthy volunteers. Uses: A novel effect of oral cck-1 agonist. Synonyms: GI-181771X; GI181771X; GI 181771X; GSKI 181771X; GSKI-181771X; GSKI181771X; (S)-3-(3-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)ureido)benzoic acid. Grade: ≥96%. CAS No. 305366-98-7. Molecular formula: C34H31N5O6. Mole weight: 605.22. | |
| GI 254023X | GI 254023X is a selective ADAM10 metalloprotease inhibitor with over 100-fold higher potency at ADAM10 than ADAM17. GI 254023X inhibits the proliferation of H929 cells, and calcium ionophore-induced betacellulin shedding in IMPE cells. It prevents E-cadherin cleavage in A549 cells, and suppresses ADAM10 mediated neuronal outgrowth of dorsal root ganglion neurons in vitro. Synonyms: GI254023X; GI 254023X; GI-254023X; GI4023; GI-4023; GI 4023. (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide. Grade: ≥98% by HPLC. CAS No. 260264-93-5. Molecular formula: C21H33N3O4. Mole weight: 391.5. | |
| GI 530159 | GI 530159 is a TREK1 and TREK2 channel activator exhibiting selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Synonyms: 4,4'-[[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis[benzenamine]; 4,4'-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline. Grade: ≥ 99 % by HPLC. CAS No. 69563-88-8. Molecular formula: C27H20F6N2O2. Mole weight: 518.45. | |
| Gibberellenic Acid | Gibberellenic Acid is a derivative of Gibberellic Acid. It is used for plant-growth stimulation. Synonyms: (1α,2β,10β)-2,7-Dihydroxy-1-methyl-8-methylene-gibba-3,4a-diene-1,10-dicarboxylic Acid; 2β,7-Dihydroxy-1-methyl-8-methylene-gibba-3,4a-diene-1α,10β-dicarboxylic Acid. Grade: > 95%. CAS No. 546-09-8. Molecular formula: C19H22O6. Mole weight: 346.38. | |
| Gibberellic Acid 3-Isolactone | Gibberellic Acid 3-Isolactone is a structural analog of Gibberellic Acid. It shows plant growth-promoting activity. Synonyms: (4bβ)-1-Methyl-2β,3α,7-trihydroxy-8-methylenegibba-4-ene-1α,10β-dicarboxylic acid 1,3-lactone; 2β,3α,7-Trihydroxy-1-methyl-8-methylenegibb-4-ene-1α,10β-dicarboxylic acid 1,3-lactone; Isogibberellic acid; Isogibberellin A3; (1α,2β,3α,4bβ,10β)-2,3,7-Trihydroxy-. Grade: > 95%. CAS No. 19123-67-2. Molecular formula: C19H22O6. Mole weight: 346.38. | |
| Gibberellin A1 | Gibberellin A1 is a derivative of Gibberellic Acid. Synonyms: 2β,4aα,7-Trihydroxy-1β-methyl-8-methylenegibbane-1α,10β-dicarboxylic acid 1,4a-lactone; 2β,4a,7-Trihydroxy-1-methyl-8-methylene-4aα,4bβ-gibbane-1α,10β-dicarboxylic Acid 1,4a-Lactone; 4a,1-(Epoxymethano)-7,9a-methanobenz[a]azulenegibbane-1,10-dicarboxylic Ac. Grade: > 95%. CAS No. 545-97-1. Molecular formula: C19H24O6. Mole weight: 348.40. | |
| Gibberellin A4 | Gibberellin A4 is a derivative of Gibberellic Acid. It is a plant growth hormone that regulates growth and differentiation of plant cells for elongation, germination and enzyme induction. Synonyms: 4a,1-(Epoxymethano)-7,9a-methanobenz[a]azulene, gibbane-1,10-dicarboxylic Acid Deriv.; GA4; 2β,4a-Dihydroxy-1-methyl-8-methylene-4aα,4bβ-gibbane-1α,10β-dicarboxylic Acid; (1α,2β,4aα,4bβ,10β)-2,4a-Dihydroxy-1-methyl-8-methylene-gibbane-1,10-dicarboxylic Acid. Grade: > 95%. CAS No. 468-44-0. Molecular formula: C19H24O5. Mole weight: 332.40. | |
| Gibberellin A5 | Gibberellin A5 is a plant hormone which promotes floral development but have little effect on stem elongation. Synonyms: C11871; (1R,2R,5S,8S,9S,10R,11R)-5-Hydroxy-11-Methyl-6-Methylidene-16-Oxo-15-Oxapentacyclo[9.3.2.1(5,8).0(1,10).0(2,8)]Heptadec-12-Ene-9-Carboxylic Acid; 4a,7-Dihydroxy-1-methyl-8-methylene-4aα,4bβ-Gibb-2-ene-1α,10β-dicarboxylic Acid 1,4a-Lactone; GA5. Grade: > 95%. CAS No. 561-56-8. Molecular formula: C19H22O5. Mole weight: 330.38. | |
| Gibberellin A9 | Gibberellin A9, an influential phytohormone, serves as a ubiquitous, biologically active plant growth regulator prevalently deployed within the agricultural sectors. Synonyms: (1R,4aR,4bR,7R,9aR,10S,10aR)-1-methyl-8-methylene-13-oxododecahydro-4a,1-(epoxymethano)-7,9a-methanobenzo[a]azulene-10-carboxylic acid. Grade: 95%. CAS No. 427-77-0. Molecular formula: C19H24O4. Mole weight: 316.4. | |
| Gibberellin A95 | Gibberellin A95 is a derivative of Gibberelic Acid. It is a stereoisomer of Gibberelin A5. Synonyms: 4a,1-(Epoxymethano)-7,9a-methanobenz[a]azulene, gibb-3-ene-1,10-dicarboxylic Acid Deriv.; GA95; NSC 224287. Grade: > 95%. CAS No. 78259-50-4. Molecular formula: C19H22O5. Mole weight: 330.38. | |
| GIBH-130 | GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses theIL-1βsecretion by activated microglia (IC50=3.4 nM). GIBH-13 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents. Synonyms: (4-methyl-6-phenylpyridazin-3-yl)-(4-pyrimidin-2; -ylpiperazin-1-yl)methanone; (4-methyl-6-phenylpyridazin-3-yl)(4-(pyrimidin-2-yl)piperazin-1-yl)methanone; GIBH-130; GIBH130; GIBH 130. CAS No. 1252608-59-5. Molecular formula: C20H20N6O. Mole weight: 360.41. | |
| Gilmelisib | Gilmelisib is a PI3K inhibitor and antineoplastic. Synonyms: PI3K-IN-20. CAS No. 1845777-61-8. Molecular formula: C24H23ClFN5O5S. Mole weight: 547.99. | |
| Gilteritinib | Gilteritinib, also known as (ASP2215, is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations. In invitro, among the 78 tyrosine kinases tested, ASP2215 inhibited FLT3, LTK, ALK, and AXL kinases by over 50% at 1 nM with an IC50 value of 0.29 nM for FLT3, approximately 800-fold more potent than for c-KIT, the inhibition of which is linked to a potential risk of myelosuppression. ASP2215 inhibited the growth of MV4-11 cells, which harbor FLT3-ITD, with an IC50 value of 0.92 nM, accompanied with inhibition of pFLT3, pAKT, pSTAT5, pERK, and pS6. ASP2215 decreased tumor burden in bone marrow and prolonged the survival of mice intravenously transplanted with MV4-11 cells. ASP2215 may have potential use in treating AML. Synonyms: ASP2215; ASP-2215; ASP 2215; Xospata; Gilteritinibum; 6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide. Grade: ≥95%. CAS No. 1254053-43-4. Molecular formula: C29H44N8O3. Mole weight: 552.71. | |
| Gilteritinib hemifumarate | Gilteritinib hemifumarate is a medication used to treat acute myeloid leukemia (AML), particularly in patients with specific genetic mutations in the FLT3 gene (FMS-like tyrosine kinase 3). Gilteritinib is a tyrosine kinase inhibitor that specifically targets and inhibits the FLT3 receptor, which is often mutated and overactive in certain types of AML. By inhibiting FLT3, gilteritinib helps to reduce the proliferation of leukemia cells. Synonyms: Gilteritinib fumarate; ASP-2215 hemifumarate; 2-Pyrazinecarboxamide, 6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-, (2E)-2-butenedioate (2:1); 6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide hemifumarate. Grade: ≥95%. CAS No. 1254053-84-3. Molecular formula: C29H44N8O3.1/2C4H4O4. Mole weight: 1221.52. | |
| Gimatecan | Gimatecan is an orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities. Gimatecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Although the mechanism of its antiangiogenic activity has yet to be full elucidated, this agent may inhibit endothelial cell migration, tumor neovascularization, and the expression of proangiogenic basic fibroblast growth factor (bFGF). Synonyms: ST1481; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(O-(1,1-dimethylethyl)oxime), (C(E),4S)-; 7-t-Butoxyiminomethylcamptothecin; (4S)-11-((E)-((1,1-DImethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione; NSC793724. Grade: ≥98%. CAS No. 292618-32-7. Molecular formula: C25H25N3O5. Mole weight: 447.48. | |
| Gimatecan HCl | Gimatecan HCl is a hydrochloride form of Gimatecan that is a camptothecin analogue with antitumor activity. Synonyms: Gimatecan hydrochloride. Grade: >95.0%. Molecular formula: C25H26ClN3O5. Mole weight: 483.94. | |
| Gimeracil Impurity 1 | Gimeracil Impurity 1. Synonyms: Gimeracil; 103766-25-2; gimestat; 5-Chloro-2,4-dihydroxypyridine; 5-chloropyridine-2,4-diol; 5-Chloro-4-hydroxy-2(1H)-pyridone; 5-Chloro-4-hydroxy-2(1H)-pyridinone; Gimeracil [INN]; 5-Chloro-4-hydroxy-1H-pyridin-2-one; 5-Chloro-2,4-pyridinediol; 5-CHLORO-4-HYDROXYPYRIDIN-2(1H)-ONE; 5-chloro-2-hydroxypyridin-4(1H)-one; 2(1H)-Pyridinone, 5-chloro-4-hydroxy-; 5-CHLORO-4-HYDROXY-2-PYRIDONE. Grade: > 95%. Molecular formula: C9H10ClNO3. Mole weight: 215.64. | |
| Gimeracil Impurity 10 | Gimeracil Impurity 10. Grade: > 95%. Molecular formula: C14H14Cl2N2O5. Mole weight: 361.18. | |
| Gimeracil Impurity 2 | Gimeracil Impurity 2. Grade: > 95%. Molecular formula: C5H5ClN2O2. Mole weight: 160.56. | |
| Gimeracil Impurity 3 | Gimeracil Impurity 3. Grade: > 95%. Molecular formula: C4H5N3O5. Mole weight: 175.10. | |
| Gimeracil Impurity 5 | Gimeracil Impurity 5. Synonyms: 5-Chloro-4-hydroxy-1-methylpyridin-2(1H)-one; Gimeracil Impurity 5; 5-chloro-4-hydroxy-1-methyl-1,2-dihydropyridin-2-one; 5-chloro-4-hydroxy-1-methylpyridin-2-one; 5-Chloro-O-demethyl-3-decyanoRicinine; CN1C(C=C(C(=C1)Cl)O)=O; MFCD19687930; AT19250; 5-Chloro-O-demethyl-3-decyano Ricinine; EN300-6496558; Z1258976765. Grade: > 95%. CAS No. 1379260-15-7. Molecular formula: C6H6ClNO2. Mole weight: 159.57. | |
| Gimeracil Impurity 6 | Gimeracil Impurity 6. Grade: > 95%. Molecular formula: C16H18Cl2N2O9. Mole weight: 453.24. | |
| Gimeracil Impurity 7 | Gimeracil Impurity 7. Synonyms: Gimeracil Impurity 7; 1227600-22-7; 5-chloro-2-hydroxy-4-methoxypyridine5-chloro-4-methoxy-1H-pyridin-2-one. Grade: > 95%. CAS No. 1227600-22-7. Molecular formula: C6H6ClNO2. Mole weight: 159.57. | |
| Gimeracil Impurity 8 | Gimeracil Impurity 8. Grade: > 95%. CAS No. 17902-24-8. Molecular formula: C8H9ClN2O3. Mole weight: 216.63. | |
| Gimeracil Impurity 9 | Gimeracil Impurity 9. Grade: > 95%. Molecular formula: C3H3N3O2. Mole weight: 113.08. | |
| Giredestrant | Giredestrant is an orally active and selective ER antagonist with anti-tumor activity. Synonyms: GDC-9545. Grade: ≥98% by HPLC. CAS No. 1953133-47-5. Molecular formula: C27H31F5N4O. Mole weight: 522.6. | |
| Giredestrant tartrate | Giredestrant tartrate is an orally active and selective ER antagonist with anti-tumor activity. Synonyms: GDC-9545 tartrate; (2R,3R)-2,3-Dihydroxysuccinic acid 3-[(1R,3R)-1-(2,6-difluoro-4-{[1-(3-fluoropropyl)-3-azetidinyl]amino}phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-β-carbolin-2-yl]-2,2-difluoro-1-propanol (1:1); Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (1R,3R)-1-[2,6-difluoro-4-[[1-(3-fluoropropyl)-3-azetidinyl]amino]phenyl]-β,β-difluoro-1,3,4,9-tetrahydro-3-methyl-2H-pyrido[3,4-b]indole-2-propanol (1:1); Estrogen receptor antagonist 1. Grade: ≥95%. CAS No. 2407529-33-1. Molecular formula: C31H37F5N4O7. Mole weight: 672.64. | |
| Girentuximab | Girentuximab is a chimeric monoclonal antibody that binds to carbonic anhydrase IX (CAIX), a cell-surface glycoprotein expressed on clear-cell RCC but not on normal kidney cells. Synonyms: G250; cG250. CAS No. 916138-87-9. | |
| Giripladib | Giripladib is a Phospholipase A2 inhibitor. Treatment with Giripladib attenuated radiation induced increases of phospho-ERK and phospho-Akt in endothelial cells. Giripladib in combination with irradiation significantly reduced migration and proliferation in endothelial cells and induced cell death and attenuated invasion by tumor cells. Uses: Antitumor. Synonyms: PLA-695; PLA 695; PLA695; Giripladib; 4-[3-[5-Chloro-1-(diphenylmethyl)-2-[2-[[[[2-(trifluoromethyl)phenyl]methyl]sulfonyl]amino]ethyl]-1H-indol-3-yl]propyl]benzoic Acid; 4-(3-[5-Chloro-1-(diphenylmethyl)-2-[2-(((2-(trifluoromethyl)benzyl)sulfonyl)amino)ethyl]-1H-indole-3-yl]propyl)benzoic Acid; PLA 695. Grade: 98%. CAS No. 865200-20-0. Molecular formula: C41H36ClF3N2O4S. Mole weight: 745.25. | |
| Gisadenafil | Gisadenafi is a potent PDE5 inhibitor (IC50 = 1.23 nM). Uses: A potent pde5 inhibitor. Synonyms: UK-369003; UK-369,003; 1-{6-ethoxy-5-[3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridylsulfonyl}-4-ethylpiperazine. Grade: ≥98%. CAS No. 334826-98-1. Molecular formula: C23H33N7O5S. Mole weight: 519.62. | |
| Gisadenafil besylate | Gisadenafil besylate is a potent PDE5 inhibitor (IC50 = 1.23 nM) with >100-fold selectivity for PDE5 over PDE6. Gisadenafil besylate inhibits the breakdown of cyclic phosphodiester secondary messenger molecules. Synonyms: UK 369003; UK369003; UK-369003; 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate. Grade: ≥99% by HPLC. CAS No. 334827-98-4. Molecular formula: C23H33N7O5S.C6H6O3S. Mole weight: 677.79. | |
| GIT 27 | GIT 27 is an orally active immunomodulatory agent. It inhibits TNF-α secretion via interference of macrophage TLR4 and TLR 2/6 signaling pathway. Synonyms: 5-Dihydro-3-phenyl-5-isoxazoleacetic acid; (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid; 3-phenyl-4,5-dihydro-5-isoxazole acetic acid; VGX-1027; VGX 1027; VGX1027; GIT 27; GIT-27; GIT27. CAS No. 6501-72-0. Molecular formula: C11H11NO3. Mole weight: 205.21. | |
| Gitoxin | Gitoxin acts as an inhibitor of the Na+/K+-ATPase, interfering with ATPase activity and used in cancer treatment as a growth inhibitor. Synonyms: Anhydrogitalin; Pseudodigitoxin; Bigitalin; Gitoxigenin 3-O-tridigitoxoside; NSC 95099. CAS No. 4562-36-1. Molecular formula: C41H64O14. Mole weight: 780.94. | |
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