BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| isobutyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate | An impurity of Febuxostat. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. Synonyms: Febuxostat Impurity 64; 3-Descyano-3-formyl Febuxostat Isobutyl Ester. CAS No. 1312815-36-3. Molecular formula: C20H25NO4S. Mole weight: 375.48. |  |
| Iso Desloratadine | Cas No. 183198-49-4. | |
| Isoflupredone | Isoflupredone is an analog of Prednisolone, which is a glucocorticoid and an anti-inflammatory drug used to treat central nervous system disorders. Uses: Anti-inflammatory. Synonyms: (11β)-9-Fluoro-11,17,21-trihydroxy-pregna-1,4-diene-3,20-dione; 9-Fluoro-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione; 9-Fluoroprednisolone; 9α-Fluoro-1-cortisol; Δ-Fluorocortisone; NSC 12174. Grades: 95%. CAS No. 338-95-4. Molecular formula: C21H27FO5. Mole weight: 378.43. | |
| iso-Ganciclovir | Iso Ganciclovir is an impurity of the anti-viral Gangiclovir. Uses: Antiviral agents. Synonyms: 2-Amino-9-[(2,3-dihydroxypropoxy)methyl]-1,9-dihydro-6H-purin-6-one; Isoganciclovir; (RS)-2-Amino-9-[(2,3-dihydroxypropoxy)methyl]-1,9-dihydro-6H-purin-6-one; Ganciclovir Related Compound A. Grades: > 95%. CAS No. 86357-09-7. Molecular formula: C9H13N5O4. Mole weight: 255.23. | |
| Isomer-II of EMTRI-111 | Isomer-II of EMTRI-111 is an intermediate of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: (2R,5R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate; Emtricitabine Impurity; 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2R,5R)-. Molecular formula: C18H26FN3O4S. Mole weight: 399.48. | |
| Isopenillic Acid | Isopenillic Acid is found when penicillin G is used for the treatment of citrus greening infected trees. Synonyms: (αS)-4-Carboxy-α-(1-mercapto-1-methylethyl)-2-(phenylmethyl)-1H-imidazole-1-acetic Acid; 2-benzyl-1-((S)-1-carboxy-2-mercapto-2-methyl-propyl)-1H-imidazole-4-carboxylic acid; Benzylpenicillin Impurity 16; 1H-Imidazole-1-acetic acid, 4-carboxy-α-(1-mercapto-1-methylethyl)-2-(phenylmethyl)-, (αS)-; 2-Benzyl-1-[(1S)-1-carboxy-2-methyl-2-sulfanylpropyl]-1H-imidazole-4-carboxylic acid. Grades: 95% by HPLC. CAS No. 90962-63-3. Molecular formula: C16H18N2O4S. Mole weight: 334.39. | |
| isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate | An impurity of Febuxostat. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. Synonyms: Febuxostat Isopropyl Ester; Febuxostat Impurity L. CAS No. 1346238-10-5. Molecular formula: C19H22N2O3S. Mole weight: 358.45. | |
| isopropyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate | isopropyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate is the impuritiy of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Synonyms: 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1-methylethyl ester, (4R,6R)-; propan-2-yl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate; Isopropyl Acetonide Atorvastatin; SCHEMBL12665703; DTXSID601099894; 1-Methylethyl (4R,6R)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate. CAS No. 1112262-71-1. Molecular formula: C39H45FN2O5. Mole weight: 640.78. | |
| Isopropyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate | An impurity of Riociguat. Riociguat is used in the treatment for pulmonary hypertension. Synonyms: [4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]methylcarbamic acid 1-methylethyl ester; Riociguat Impurity 14. CAS No. 625115-54-0. Molecular formula: C22H23FN8O2. Mole weight: 450.47. | |
| isopropyl 4-methylbenzenesulfonate | Isopropyl 4-Methylbenzenesulfonate (CAS# 2307-69-9) is a sulfonic acid ester, a potentialy alkylating agent. Studies suggest Isopropyl p-Tosylate may exert genotoxic effects in bacterial and mammalian cell systems. Synonyms: Isopropyl p-Tosylate; 2-Propyl tosylate; 4-Methylbenzenesulfonic Acid 1-Methylethyl Ester. CAS No. 2307-69-9. Molecular formula: C10H14O3S. Mole weight: 214.28. | |
| Isopropyl (7,7-Dimethyl-1,3-Oxobicyclo[2,2,1]hept-1-yl)methane Sulfonate | Grades: > 95%. Molecular formula: C13H22O4S. Mole weight: 274.38. | |
| Isopropyl methanesulfonate | Isopropyl Methanesulfonate (CAS# 926-06-7) is used in studies to evaluate the carcinogenicity effect in the skin and thymus from methyl methanesulfonate. Synonyms: 2-Propyl Methanesulfonate; Isopropyl Mesylate; Methanesulfonic Acid, 1-Methylethyl Ester; Methanesulfonic Acid, Isopropyl Ester. CAS No. 926-06-7. Molecular formula: C4H10O3S. Mole weight: 138.19. | |
| Isopropyl (S)-2-hydroxy-2-phenylacetate | Synonyms: 2-Propanol (S)-mandelate; L-Mandelic acid isopropyl ester; Benzeneacetic acid, α-hydroxy-, 1-methylethyl ester, (αS)-; Isopropyl (2S)-hydroxy(phenyl)acetate. Grades: 98%. CAS No. 53439-96-6. Molecular formula: C11H14O3. Mole weight: 194.23. | |
| Isotretinoin (13-cis-Retinoic Acid) | Isotretinoin is a retinoic acid derivative developed as a drug for the treatment of cystic acne. It also can be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. Uses: Dermatologic agents; teratogens. Synonyms: 13-cis-Retinoic acid; Accutane; Roaccutane. Grades: >98%. CAS No. 4759-48-2. Molecular formula: C20H28O2. Mole weight: 300.44. | |
| Isotretinoin EP Impurity F | . Uses: A retinoid compound with reduced toxicity than the starting or parent retinoid. Synonyms: 11-cis Retinoic Acid; (11Z)-retinoic acid; (7E,9E,11Z,13E)-retinoic acid; (2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid. Grades: 95%. CAS No. 68070-35-9. Molecular formula: C20H28O2. Mole weight: 300.43. | |
| Ispinesib | Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Synonyms: SB-715992; SB715992; SB 715992; CK 0238273; CK-0238273; CK0238273. CAS No. 336113-53-2. Molecular formula: C30H33ClN4O2. Mole weight: 517.07. | |
| Isradipine | Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure. Synonyms: DynaCirc; Prescal; Lomir; PN-200-110; PN-205-033; PN-205-034; 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester. Grades: >98%. CAS No. 75695-93-1. Molecular formula: C19H21N3O5. Mole weight: 371.39. | |
| Istradefylline Dimer 2 | Istradefylline Dimer 2 is a dimer of Istradefylline, which is a selective A(2A) antagonist used in the treatment of Parkinson's disease. Synonyms: 8,8'-((1R,2R,3S,4S)-2,4-Bis(3,4-dimethoxyphenyl)cyclobutane-1,3-diyl)bis(1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione); 1H-Purine-2,6-dione, 8,8'-[(1α,2α,3β,4β)-2,4-bis(3,4-dimethoxyphenyl)-1,3-cyclobutanediyl]bis[1,3-diethyl-3,7-dihydro-7-methyl-; Istradefylline Impurity 25. CAS No. 702697-27-6. Molecular formula: C40H48N8O8. Mole weight: 768.86. | |
| Istradefylline M8 | Istradefylline M8 is one of Istradefylline metabolites, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Synonyms: 8-[(E)-2-(3,4-Dimethoxyphenyl)vinyl]-3-ethyl-1-(2-hydroxyethyl)-7-methyl-3,7-dihydro-1H-purine-2,6-dione; 1H-Purine-2,6-dione, 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-3-ethyl-3,7-dihydro-1-(2-hydroxyethyl)-7-methyl-; (E)-8-(3,4-dimethoxystyryl)-3-ethyl-1-(2-hydroxyethyl)-7-methyl-1H-purine-2,6(3H,7H)-dione. CAS No. 1798429-54-5. Molecular formula: C20H24N4O5. Mole weight: 400.43. | |
| ITI214 | ITI214 is a highly selective PDE1 inhibitor (Ki = 58 pM) at picomolar concentration without disrupting other PDE family members and a panel of enzymes, receptors, transporters, and ion channels. Synonyms: Lenrispodun phosphate; PDE1-IN-1 (phosphate); ITI 214; ITI-214. CAS No. 1642303-38-5. Molecular formula: C29H29FN7O5P. Mole weight: 605.56. | |
| Itraconazole | Itraconazole, a triazole antifungal agent, is a relatively potent inhibitor of CYP3A4. Uses: Antifungal agents; antiprotozoal agents. Synonyms: Itraconazole, R51211, R 51211, R-51211, Orungal, Oriconazole, Sporanox, Itraconazolum, Itraconazol, Itrizole. Grades: >98%. CAS No. 84625-61-6. Molecular formula: C35H38Cl2N8O4. Mole weight: 705.63. | |
| Ivabradine Impurity 15 | An impurity of Ivabradine, which is a novel heart rate lowering medication. It can slow the heart rate by hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers. Ivabradine is marketed under trade names including Coralan, Corlentor, Procoralan, Coraxan. Synonyms: 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-4,5-dihydro-7,8-dimethoxy-1H-3-benzazepine-1,2(3H)-dione; 2-Oxo-ivabradine Hydrochloride. Grades: 95%. CAS No. 1616710-50-9. Molecular formula: C27H35ClN2O6. Mole weight: 519.03. | |
| Ivabradine R-Isomer HCl | The enantiomer of Ivabradine Hydrochloride. Ivabradine is a medication used to reduce the risk of hospitalization for worsening heart failure in adult patients with stable, symptomatic chronic heart failure. Synonyms: ent-Ivabradine Hydrochloride; 3-[3-[[[(7R)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride. Grades: > 95%. CAS No. 148849-68-7. Molecular formula: C27H37ClN2O5. Mole weight: 505.06. | |
| Ivacaftor | Ivacaftor is a potentiator of CFTR targeting G551D-CFTR(EC50=100 nM)and F508del-CFTR(EC50=25 nM). Ivacaftor is used in the treatment of cystic fibrosis. Uses: Chloride channel agonists. Synonyms: N-[2,4-Bis[1,1-di(methyl)ethyl]-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide; Ivacaftor; Kalydeco; VX-770; VX 770; VX770. Grades: 98%. CAS No. 873054-44-5. Molecular formula: C24H28N2O3. Mole weight: 392.49. | |
| Ivacaftor Acyl-Glucuronide | Ivacaftor Acyl-Glucuronide is an impurity of Ivacaftor, which is a CFTR potentiator used in the treatment of cystic fibrosis. Molecular formula: C30H34N2O10. Mole weight: 582.60. | |
| Ivacaftor Carboxylic Acid Lactone | Ivacaftor Carboxylic Acid Lactone is related to Ivacaftor, which is a CFTR potentiator used in the treatment of cystic fibrosis. Synonyms: N-[5-(1,1-Dimethylethyl)-2,3-dihydro-3,3-dimethyl-2-oxo-6-benzofuranyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide; N-(5-(tert-Butyl)-3,3-dimethyl-2-oxo-2,3-dihydrobenzofuran-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxamide. Grades: ≥95%. CAS No. 1246213-41-1. Molecular formula: C24H24N2O4. Mole weight: 404.46. | |
| Ivacaftor-N-Glucuronide | Ivacaftor-N-Glucuronide is a metabolite of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: Ivacaftor N-β-D-Glucuronide. Grades: 98%. Molecular formula: C30H36N2O9. Mole weight: 568.61. | |
| Ivacaftor-O-Glucuronide | Ivacaftor-O-Glucuronide is a metabolite of Ivacaftor, a drug used in the treatment of cystic fibrosis. Synonyms: Ivacaftor O-β-D-Glucuronide. Grades: 98%. Molecular formula: C30H36N2O9. Mole weight: 568.61. | |
| Ivosidenib | Ivosidenib is an oral inhibitor that specifically inhibits a mutated form of IDH1 in the cytoplasm, which blocks the proliferation of tumor cells expressing IDH1. Synonyms: AG-120; AG 120; AG120; (2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide. CAS No. 1448347-49-6. Molecular formula: C28H22ClF3N6O3. Mole weight: 582.968. | |
| Ixabepilone | Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007. Synonyms: Azaepothilone B; BMS247550; BMS-247550; BMS 247550; Ixempra. Grades: >98%. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. | |
| J 147 | J 147, under the IUPAC name N- (2, 4-dimethylphenyl) -2, 2, 2-trifluoro-N-[ (E) - (3-methoxyphenyl) methylideneamino]acetamide, is a phenyl hydrazide compound that has been shown to prevent memory deficits in an Alzheimer's disease mouse model. in vitro: A potent neuroprotective and neurotrophic compound (EC50 = 25 - 200 nM) in vivo: Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus. Uses: Implicated in alzheimer's disease. Synonyms: J147; J 147; J-147. N- (2, 4-dimethylphenyl) -2, 2, 2-trifluoro-N-[ (E) - (3-methoxyphenyl) methylideneamino]acetamide; J-147; 1146963-51-0; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide; CHEMBL2387144; SCHEMBL12995834; 3752AH; AKOS024458485; CS-3688; AK279964; BC600735; HY-13779; 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene]hydrazide; J 147|2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide. CAS No. 1146963-51-0. Molecular formula: C18H17F3N2O2. Mole weight: 350.33. | |
| JD-5037 | Jd-5037 is a peripherally-restricted cannabinoid inverse agonist at CB1 receptors that can be used as an anti-obesity drug, with a 700-fold higher affinity compared to CB2 receptors. Synonyms: JD 5037; JD5037; (S) -2- ( ( (E) - ( (S) -3- (4-chlorophenyl) -4-phenyl-4, 5-dihydro-1H-pyrazol-1-yl) ( (4-chlorophenyl) sulfonamido) methylene) amino) -3-methylbutanamide. Grades: >98%. CAS No. 1392116-14-1. Molecular formula: C27H27Cl2N5O3S. Mole weight: 572.5. | |
| JE-2147 | JE-2147 is a dipeptide HIV protease inhibitor (PI) that is effective against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro. Synonyms: (4R)-3-[(2S,3S)-2-Hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl]-5,5-dimethyl-N-[(2-methylphenyl)methyl]-1,3-thiazolidine-4-carboxamide. CAS No. 186538-00-1. Molecular formula: C32H37N3O5S. Mole weight: 575.7. | |
| JHU37160 | JHU37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist. It has high affinity in vitro for hM3Dq and hM4Di (Ki values are 1.9 nM (hM3Dq) and 3.6 nM (hM4Di). Synonyms: JHU 37160; JHU-37160. CAS No. 2369979-68-8. Molecular formula: C19H20ClFN4. Mole weight: 358.84. | |
| JK-P3 | JK-P3 is a VEGFR2 inhibitor with IC50 values of 7.8 μM. JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but exhibits no effect on FGFR signaling in cell-based assays. It suppresses wound healing and tube formation in HUVEC without effecting endothelial cell proliferation. Synonyms: 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide. CAS No. 942655-44-9. Molecular formula: C18H17N3O3. Mole weight: 323.352. | |
| JNJ 0966 | JNJ 0966 is a selective inhibitor of MMP-9 (IC50 = 440 nM) with no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity. JNJ 0966 was indicated to alleviate the pain of experimental autoimmune encephalomyelitis in a mouse model. Synonyms: JNJ-0966; JNJ0966; N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide. Grades: ≥98% by HPLC. CAS No. 315705-75-0. Molecular formula: C16H16N4O2S2. Mole weight: 360.45. | |
| JNJ-26483327 | JNJ-26483327 is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB). Synonyms: JNJ-26483327; JNJ 26483327; JNJ26483327. CAS No. 807640-87-5. Molecular formula: C22H25BrN4O2. Mole weight: 457.372. | |
| JNJ 63533054 | JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Synonyms: 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide; GTPL8766; GTPL 8766; GTPL-8766; JNJ 63533054; JNJ63533054; JNJ-63533054. Grades: 98%. CAS No. 1802326-66-4. Molecular formula: C17H17ClN2O2. Mole weight: 316.785. | |
| JNK-IN-8 | JNK-IN-8 inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively. Uses: Protein kinase inhibitors. Synonyms: JNK-IN-8; JNK-IN 8; JNK-IN8; JNK Inhibitor XVI; c-Jun N-terminal Kinase Inhibitor XVI. Grades: >98%. CAS No. 1410880-22-6. Molecular formula: C29H29N7O2. Mole weight: 507.59. | |
| JPH203 | JPH203 is a potent and selective L-type amino acid transporter 1 (LAT1) inhibitor. It inhibits 14C-leucine uptake and cell growth in human colon cancer-derived HT-29 cells in vitro. It also inhibits 14C-leucine uptake in mouse renal proximal tubule cells expressing l-type amino acid transporter 1, and inhibits cell growth. It completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner. It suppresses proliferation in cancer cell lines and is used for cancer research. It was developed by J-Pharma and in clinic phase 1 trials. Uses: Jph203 suppresses proliferation in cancer cell lines and is used for cancer research. Synonyms: KYT-0353;KYT0353;JPH-203; KYT 0353;JPH 203;(S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid. Grades: >98 %. CAS No. 1037592-40-7. Molecular formula: C23H19Cl2N3O. Mole weight: 472.32. | |
| (+)-JQ-1 | (+)-JQ-1 is a potent and selective BET bromodomain inhibitor, IC50 values are 77 nM and 33 nM for inhibiting BRD4 (N-terminal) and BRD4 (C-terminal), respectively. Synonyms: JQ1. CAS No. 1268524-70-4. Molecular formula: C23H25ClN4O2S. Mole weight: 456.99. | |
| JTE-013 | JTE-013 is a potent and selective sphingosine-1-phosphate (S1P) receptor 2 (S1P2) antagonist (IC50=17.6 nM). Synonyms: 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea; JTE-013; JTE 013; JTE013. Grades: >98%. CAS No. 383150-41-2. Molecular formula: C17H19Cl2N7O. Mole weight: 408.287. | |
| JX 06 | JX 06 is a potent, selective and covalent pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor with IC50 values of 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively. It suppresses A549 lung cancer cell proliferation in vitro and reduces tumor volume of A549 xenografts in mice. Synonyms: JX-06; JX06; Bis(morpholinothiocarbonyl) Disulfide; 4, 4'- (Dithiodicarbonothioyl) bis[morpholine]; 4-Morpholinethiocarbonyl Disulfide; Dimorpholinethiuram Disulfide; Disulfide, bis(4-Morpholinylthioxomethyl); NSC 402538; bis(Oxydi-2,1-ethanediyl)-thiuram Disulfide. Grades: ≥98% by HPLC. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.51. | |
| K03861 | K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. Synonyms: AUZ 454; K 03861; K-03861; Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-; 1-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-3-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea. Grades: 98%. CAS No. 853299-07-7. Molecular formula: C24H26F3N7O2. Mole weight: 501.50. | |
| K-7174 dihydrochloride | K-7174, one of proteasome inhibitory homopiperazine derivatives, exhibits a therapeutic effect, which is stronger when administered orally than intravenously, without obvious side effects in a murine myeloma model. Moreover, K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib. Synonyms: 1,4-bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane dihydrochloride; K7174; K 7174; K-7174; K-7174-2HCl; K-7174 dihydrochloride. Grades: >98%. CAS No. 191089-60-8. Molecular formula: C33H50Cl2N2O6. Mole weight: 641.67. | |
| Kallikrein Inhibitor | Kallikrein Inhibitor, a synthetic peptide, is a serine protease inhibitor that inhibits kallikrein and plasmin, and can attenuate breast cancer cell invasion. Synonyms: KKI 5; KKI-5; KKI5; Ac-Pro-phe-arg-ser-val-gln-NH2; (S)-2-((3S,6S,9S,12S)-1-((S)-1-acetylpyrrolidin-2-yl)-3-benzyl-6-(3-guanidinopropyl)-9-(hydroxymethyl)-12-isopropyl-1,4,7,10-tetraoxo-2,5,8,11-tetraazatridecan-13-amido)pentanediamide; N-acetyl-L-prolyl-L-phenylalanyl-L-arginyl-L-seryl-L-valyl-L-glutaminamide. Grades: >98%. CAS No. 97145-43-2. Molecular formula: C35H55N11O9. Mole weight: 773.88. | |
| KDM5-inhibitor | KDM5-inhibitor is an analog of CPI-455, a selective KDM5 inhibitor. CPI-455 increases levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell lines treated with standard chemotherapy or targeted agents. It reduces survival of drug-tolerant cancer cells. Synonyms: KDM5 inhibitor; 7-oxo-5-phenyl-6-propyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Molecular formula: C16H14N4O. Mole weight: 278.315. | |
| Ketotifen Impurity B | Ketotifen impurity, used in separation of enantiomers of Ketotifen and its polar intermediate by isotachophoresis. Synonyms: 4-Hydroxy-9,10-dehydro-10-methoxy Ketotifen; 10-Methoxy-4-(1-methyl-4-piperidinyl)-4H-benzo[4,5]cyclohepta[1,2-b]thiophene-4-ol. Grades: > 95%. CAS No. 59743-88-3. Molecular formula: C20H23NO2S. Mole weight: 341.48. | |
| KGA2727 | KGA2727 is a selective and potent SGLT1 inhibitor for the treatment of diabete. Its inhibition constant (Ki) values of 97 and 13,600 nM for human (h) SGLT1 and hSGLT2 respectively. It inhibited the absorption of glucose but not that of fructose. Uses: Kga2727 is used for the treatment of diabete. Synonyms: KGA-2727; KGA 2727; 3- (3-{4-[3- (beta-D-glucopyranosyloxy) -5-isopropyl-1Hpyrazol-4-ylmethyl]-3-methylphenoxy}propylamino) propionamide. Grades: 98%. CAS No. 666842-36-0. Molecular formula: C26H40N4O8. Mole weight: 536.63. | |
| Ki20227 | Ki-20227 is a highly selective c-Fms tyrosine kinase(CSF1R) inhibitor. Synonyms: Ki20227; Ki 20227; Ki-20227. Grades: >98%. CAS No. 623142-96-1. Molecular formula: C24H24N4O5S. Mole weight: 480.54. | |
| KIN1148 | KIN1148, a small-molecule IRF3 agonist, associates with and activates recombinant RIG-I protein in cell-free assays. KIN1148 is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy. Synonyms: KIN-1148; KIN 1148; KIN1148; N-([1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)naphthalene-2-carboxamide. Grades: ≥98% (HPLC). CAS No. 1428729-56-9. Molecular formula: C19H11N3OS2. Mole weight: 361.44. | |
| KIRA6 | KIRA6 allosterically inhibits IRE1α RNase kinase activity in vivo and promotes cell survival under ER stress. Systemically, KIRA6 preserves pancreatic β cells, increases insulin, and reduces hyperglycemia in Akita diabetic mice. Synonyms: KIRA6; KIRA-6; KIRA 6; 1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea; 1-(4-(8-amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea; KIRA analog, 2. CAS No. 1589527-65-0. Molecular formula: C28H25F3N6O. Mole weight: 518.53. | |
| Kisspeptin-10 | Kisspeptin-10, also called Metastin (45-54), is a potent vasoconstrictor and endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Synonyms: Metastin (45-54); Kp-10; H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2; L-tyrosyl-L-asparagyl-L-tryptophyl-L-asparagyl-L-seryl-L-phenylalanyl-glycyl-L-leucyl-L-arginyl-L-phenylalaninamide; KISS1; Kisspeptin 10 (human). Grades: ≥95%. CAS No. 374675-21-5. Molecular formula: C63H83N17O14. Mole weight: 1302.44. | |
| KL-11743 | KL-11743 is a potent, orally active and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90 and 68 nM for GLUT1, GLUT2, GLUT3 and GLUT4, respectively. It specifically blocks glucose metabolism and induces cell death in concert with electron transport inhibitors. Synonyms: NSC783733; Acetamide, 2-[3-[6-ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-. Grades: ≥98%. CAS No. 1369452-53-8. Molecular formula: C30H30N6O3. Mole weight: 522.60. | |
| KNK437 | KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40. Synonyms: KNK437; KNK-437; KNK 437. Grades: 98%. CAS No. 218924-25-5. Molecular formula: C13H11NO4. Mole weight: 245.23. | |
| Kpt-330, (E)- | Cas No. 1421923-86-5. | |
| KW-2449 | KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. Synonyms: KW2449; KW-2449; KW 2449. CAS No. 1000669-72-6. Molecular formula: C20H20N4O. Mole weight: 332.407. | |
| KX2-391 | KX2-391 is an orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to the ATP-binding site, Src kinase inhibitor KX2-391 specifically binds to the peptide substrate binding site of Src kinase; inhibition of kinase activity may result in the inhibition of primary tumor growth and the suppression of metastasis. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation and metastasis. Uses: Enzyme inhibitors. Synonyms: KX01, KX-01, KX 01, KX2-391; KX-2-391; KX 2-391; KX2391; KX-2391; KX 2391; Tirbanibulin. CAS No. 897016-82-9. Molecular formula: C26H29N3O3. Mole weight: 431.53. | |
| KY-226 | KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice. Uses: Enzyme inhibitors. Synonyms: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide; BCP32729; EX-A3829. CAS No. 1621673-53-7. Molecular formula: C27H31NO3S2. Mole weight: 481.7. | |
| L-778123 HCl | L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. Synonyms: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride; L778123; L-778123; L 778123; L778,123; L-778,123; L 778,123 HCl. Grades: 98%. CAS No. 253863-00-2. Molecular formula: C22H20ClN5O. Mole weight: 405.88. | |
| Labetalol-1-carboxylic Acid Methyl Ester | An impurity of Labetalol, a beta blocker used to treat high blood pressure. Synonyms: Methyl labetalol acid; Labetalol Impurity B. CAS No. 802620-01-5. Molecular formula: C20H25NO4. Mole weight: 343.4. | |
| Labetalol Impurity A | Labetalol Impurity A is an impurity of Labetalol, a medication used for the treatment of high blood pressure, and also for long term management of angina. Synonyms: Labetalol-1-carboxylic Acid; Labetalol acid; 2-Hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)benzoic acid. Grades: ≥98%. CAS No. 1391051-99-2. Molecular formula: C19H23NO4. Mole weight: 329.40. | |
| Labetalol Impurity C | an intermediate of Labetalol Impurity. Synonyms: 5-(N,N-Dibenzylglycyl)salicylamide. Grades: > 95%. CAS No. 30566-92-8. Molecular formula: C23H22N2O3. Mole weight: 374.44. | |
| Lacidipine | Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Lacidipine (Lacipil, Motens) works by relaxing and opening up the blood vessels. Synonyms: GX-1048,GR-43659X,SN-305; GX 1048,GR 43659X,SN 305; GX1048,GR43659X,SN305. Grades: >98%. CAS No. 103890-78-4. Molecular formula: C26H33NO6. Mole weight: 455.54. | |
| Lacosamide EP Impurity I | One of the impurities of Lacosamide. Lacosamide is a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Synonyms: (R)-N-Benzyl-2-(3-benzylureido)-3-methoxypropanamide. CAS No. 2295925-90-3. Molecular formula: C19H23N3O3. Mole weight: 341.40. | |
| Lacosamide Impurity I | Cas No. 2295925-90-3. | |
| L-Ala(10)-Cetrorelix | L-Ala(10)-Cetrorelix is an impurity of Cetrorelix, which is a gonadotropin-releasing hormone antagonist used in the treatment of prostate and breast cancers. Synonyms: Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-Ala-NH2; (S)-N-((S)-1-amino-1-oxopropan-2-yl)-1-((2S,5S,8R,11S,14S,17R,20R,23R)-20-(4-chlorobenzyl)-2-(3-((diaminomethylene)amino)propyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-23-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(pyridin-3-ylmethyl)-8-(3-ureidopropyl)-3,6,9,12,15,18,21,24-octaazahexacosanoyl)pyrrolidine-2-carboxamide; N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-D-citrullyl-L-leucyl-L-arginyl-L-prolyl-L-alaninamide. CAS No. 2886712-13-4. Molecular formula: C70H92ClN17O14. Mole weight: 1431.06. | |
| Laminin (925-933) | Laminin β-1 Chain (925-933) (human, mouse) is a peptide derivative from residues 925-933 of the laminin B1 chain. It binds to the laminin receptor. Synonyms: Laminin beta-1 Chain (925-933) (human, mouse); Laminin β-1 Chain (925-933) (human, mouse); Laminin Fragment 925-933; H-Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-OH; L-cysteinyl-L-alpha-aspartyl-L-prolyl-glycyl-L-tyrosyl-L-isoleucyl-glycyl-L-seryl-L-arginine. Grades: 98%. CAS No. 110590-60-8. Molecular formula: C40H62N12O14S. Mole weight: 967.06. | |
| Lamivudine Impurity 6 | Lamivudine Impurity 6 is an impurity of Lamivudine, which is a potent nucleoside reverse transcriptase inhibitor and antiviral agent used to treat chronic hepatitis B. Synonyms: [1R-[1α(2S*, 5R*), 2β, 5α]]-5-Hydroxy-5-methyl-2-(1-methylethyl)cyclohexyl ester 1,3-Oxathiolane-2-carboxylic Acid; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2S,5R)-5-hydroxy-1,3-oxathiolane-2-carboxylate; 1,3-Oxathiolane-2-carboxylic acid, 5-hydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2S,5R)-. Grades: ≥95%. CAS No. 147126-64-5. Molecular formula: C14H24O4S. Mole weight: 288.40. | |
| Lamivudine Monophosphate Triethylammonium Salt | Lamivudine Monophosphate Triethylammonium Salt is a metabolite of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: 4-Amino-1-[(2R,5S)-2-[(phosphonooxy)methyl]-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone Triethylammonium Salt; ((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl dihydrogen phosphate Triethylammonium Salt. Molecular formula: C8H12N3O6PS.xC6H15N. Mole weight: 309.24 (free acid). | |
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