BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| GPP 78 hydrochloride | GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), which is subsequently converted to NAD+. It was shown to induce autophagy in neuroblastoma cells. Synonyms: GPP 78 hydrochloride; GPP78 hydrochloride; GPP-78 hydrochloride; N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride. Grade: ≥98% by HPLC. Molecular formula: C27H29N5O.HCl. Mole weight: 476.01. |  |
| GppNH2 | GppNH2, one of the analogue of GTP, has been found to be probably useful in studies of modulating cell signals related to G proteins. Synonyms: GMPPN; Guanosine-5'-(β-amino)-diphosphate. Grade: ≥ 95 % by HPLC. Molecular formula: C10H16N6O10P2. Mole weight: 442.21. | |
| GppNHp - Tetralithium salt | The tetrasodium salt form of GppNH2, one of the analogue of GTP, has been found to be probably useful in studies of modulating cell signals related to G proteins. Synonyms: GMPPNP; Guanosine-5'-[( β,γ )-imido]triphosphate, Tetralithium salt; GMPPNHP. Grade: ≥ 95 % by HPLC. CAS No. 64564-03-0. Molecular formula: C10H13N6ONa413P3. Mole weight: 611.13. | |
| GppNHp - Trisodium salt | The trisodium salt form of GppNH2, one of the analogue of GTP, has been found to be probably useful in studies of modulating cell signals related to G proteins. Synonyms: GMPPNP; Guanosine-5'-[( β,γ )-imido]triphosphate, Trisodium salt; GMPPNHP. Grade: ≥ 90 % by HPLC. CAS No. 148892-91-5. Molecular formula: C10H14N6Na3O13P3. Mole weight: 588.14. | |
| GPR120 Agonist 1 | GPR120 Agonist 1 is a potent and selective GPR120 agonist with promising antidiabetic effects and good safety. Synonyms: GPR120 agonist 4x; 3-(4-((3-(4-chloro-2-fluorophenyl)-5-(trifluoromethyl)isothiazol-4-yl)methoxy)-3,5-difluorophenyl)propanoic acid; Benzenepropanoic acid, 4-[[3-(4-chloro-2-fluorophenyl)-5-(trifluoromethyl)-4-isothiazolyl]methoxy]-3,5-difluoro-. Grade: ≥95%. CAS No. 1628448-77-0. Molecular formula: C20H12ClF6NO3S. Mole weight: 495.82. | |
| GPR120-IN-1 | GPR120-IN-1, a cell-permeable azaspiroundecanyl acetic acid compound, is an orally available, selective agonist of GPR120 (EC50 = ~0.35 μM) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1). Synonyms: 2-[3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid; GPR120 Compound A; MDK77754; MDK-77754; MDK 77754; GPR120 cpdA. CAS No. 1599477-75-4. Molecular formula: C19H23ClF3NO3. Mole weight: 405.84. | |
| GPR120 modulator 1 | GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 (GPR120). Synonyms: GPR120 modulator 1; 1050506-75-6; 2-[4-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]methoxy]-2-methylphenoxy]acetic acidAcetic acid, 2-[4-[[4-(2-chlorophenyl)-2-thiazolyl]methoxy]-2-methylphenoxy]-GPR120-modulator-1. Grade: >98%. CAS No. 1050506-75-6. Molecular formula: C19H16ClNO4S. Mole weight: 389.85. | |
| GPR120 modulator 2 | GPR120 modulator 2 is useful for modulating G protein-coupled receptor 120 (GPR120). Synonyms: GPR120 modulator 2; 1050506-87-0; 3-[4-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]methoxy]-2-methylphenyl]propanoic acidBenzenepropanoic acid, 4-[[4-(2-chlorophenyl)-2-thiazolyl]methoxy]-2-methyl-3-(4-{[4-(2-CHLOROPHENYL)-1,3-THIAZOL-2-YL]METHOXY}-2-METHYLPHENYL)PROPANOIC ACID. Grade: >98%. CAS No. 1050506-87-0. Molecular formula: C20H18ClNO3S. Mole weight: 387.88. | |
| GPR132 antagonist 1 | GPR132 antagonist 1 is a GPR132 antagonist with EC50 value of 0.075 μM. Synonyms: NOX-6-18. CAS No. 898211-21-7. Molecular formula: C18H17NO5S. Mole weight: 359.40. | |
| GPR139 agonist-2 | GPR139 agonist-2 is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 has the potential for antischizophrenia drug research. Synonyms: (S)-2-(4-Oxopyrrolo[1,2-d][1,2,4]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide. CAS No. 2983118-29-0. Molecular formula: C17H15F3N4O3. Mole weight: 380.32. | |
| GPR30 agonist-1 | GPR30 agonist-1 is an agonist of G protein-coupled receptor 30 (GPR30) with vasorelaxant effects. Synonyms: 3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aS,4R,9bR)-. Grade: ≥98%. CAS No. 415919-74-3. Molecular formula: C19H17BrFNO. Mole weight: 374.25. | |
| GPR34 receptor antagonist 2 | GPR34 receptor antagonist 2 is a GPR34 receptor antagonist. Grade: 97%. CAS No. 907952-06-1. Molecular formula: C31H26ClNO4. Mole weight: 512.0. | |
| GPR35 activator-1 | GPR35 activator-1 is a potent GPR35 activator with a Ki of 0.08 nM for human GPR35. CAS No. 2855918-34-0. Molecular formula: C25H18N6O4. Mole weight: 466.45. | |
| GPR35 agonist 1 | GPR35 agonist 1 is a potent and specific GPR35/CXCR8 agonist with an EC50 of 5.8 nM. Synonyms: 6-Bromo-7-hydroxy-8-nitro-3-(1H-tetrazol-5-yl)-2H-chromen-2-one. CAS No. 2079880-92-3. Molecular formula: C10H4BrN5O5. Mole weight: 354.07. | |
| GPR35 agonist 5 | GPR35 agonist 5 is a weak GPR35 agonist. Synonyms: 3,5-dinitro-bisphenol A. CAS No. 2226201-24-5. Molecular formula: C15H14N2O6. Mole weight: 318.28. | |
| Gpr35 modulator 1 | Gpr35 modulator 1 is a potent modulator of Gpr35. CAS No. 2994189-01-2. Molecular formula: C23H14ClF2N5O3. Mole weight: 481.84. | |
| Gpr35 modulator 2 | Gpr35 modulator 2 is a potent modulator of Gpr35. CAS No. 3049339-96-7. Molecular formula: C28H23FN2O4. Mole weight: 470.49. | |
| Gpr35 modulator 3 | Gpr35 modulator 3 is a potent modulator of Gpr35. CAS No. 3055887-18-5. Molecular formula: C25H19FN6O2. Mole weight: 454.46. | |
| GPR40 Activator 1 | GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes. Synonyms: GPR40 Activator 1. Grade: >98%. CAS No. 1309435-60-6. Molecular formula: C31H31NO3S. Mole weight: 497.65. | |
| GPR40 Activator 2 | GPR40 Activator 2 is a potent GPR40 activator from patents WO 2012147516 A1, WO 2012046869A1 and WO 2011078371 A1. Synonyms: GPR40 Activator 2. Grade: >98%. CAS No. 1312787-30-6. Molecular formula: C28H29NO6S2. Mole weight: 539.66. | |
| GPR40 agonist 1 | GPR40 agonist 1 is a potent full agonist of GPR40 with EC50s of 2 and 17 nM for hGPR40 and rGPR40, respectively. Synonyms: Benzenepropanoic acid, β-cyclopropyl-3-[[5-(5-fluoro-2-methoxy-4-pyridinyl)-6-(2-methylpropyl)-2-pyrazinyl]methoxy]-, (βS)-; (3S)-3-Cyclopropyl-3-(3-((5-(5-fluoro-2-methoxypyridin-4-yl)-6-isobutylpyrazin-2-yl)methoxy)phenyl)propanoic acid. Grade: ≥95%. CAS No. 1853982-41-8. Molecular formula: C27H30FN3O4. Mole weight: 479.54. | |
| GPR40 Agonist 2 | GPR40 Agonist 2, an agonist of G-protein coupled receptor 40 (GPR40), can be used in diabetes research. (Extracted from patent WO2009054479A1). Synonyms: Benzenepropanoic acid, β-1-propyn-1-yl-4-(spiro[5.5]undec-2-en-2-ylmethoxy)-, (βS)-; (S)-3-[4-(spiro[5.5]undec-2-en-2-ylmethoxy)-phenyl]-hex-4-ynoic acid; (3S)-3-[4-(Spiro[5.5]undec-2-en-2-ylmethoxy)phenyl]-4-hexynoic acid. CAS No. 1147729-48-3. Molecular formula: C24H30O3. Mole weight: 366.49. | |
| GPR40/FFAR1 modulator 1 | GPR40/FFAR1 modulator 1 is an agonist and allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1). Synonyms: 7-({4-amino-6-[(2-methylphenyl)amino]-1,3,5-triazin-2-yl}methoxy)-4-methyl-2H-chromen-2-one; 2H-1-Benzopyran-2-one, 7-[[4-amino-6-[(2-methylphenyl)amino]-1,3,5-triazin-2-yl]methoxy]-4-methyl-. Grade: ≥95%. CAS No. 874755-26-7. Molecular formula: C21H19N5O3. Mole weight: 389.41. | |
| GPR4 antagonist 1 | A GPR4 antagonist, with an IC50 of 189 nM. Synonyms: GPR4 receptor modulator 46. CAS No. 1197879-16-5. Molecular formula: C27H37N5. Mole weight: 431.62. | |
| GPR55 agonist 3 | GPR55 agonist 3 is a GPR55 agonist and it induces β-arrestin recruitment to human GPR55. CAS No. 3006105-44-5. Molecular formula: C19H16F4N4. Mole weight: 376.35. | |
| GPR55 agonist 4 | GPR55 agonist 4 is a GPR55 agonist and it induces β-arrestin recruitment to human GPR55. CAS No. 3006105-55-8. Molecular formula: C19H16FN5O2. Mole weight: 365.36. | |
| GPR84 antagonist 1 | GPR84 antagonist 1 is a high affinity and highly selective human GPR84 competitive antagonist. Molecular formula: C26H22N4O2. Mole weight: 422.48. | |
| GPR84 antagonist 2 | GPR84 antagonist 2 is a potent, selective and orally active GPR84 antagonist (IC50 = 8.95 nM), which has the potential for the study of ulcerative colitis. It shows improved potency in the calcium mobilization assay and inhibits the chemotaxis of neutrophils and macrophages upon GPR84 activation. Synonyms: Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1). CAS No. 2244269-74-5. Molecular formula: C28H16Cl2NaO4PS2. Mole weight: 605.42. | |
| GPR84 antagonist 8 | GPR84 antagonist 8 is a selective antagonist of GPR84. Synonyms: 4H-Pyrimido[6,1-a]isoquinolin-4-one, 2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydro-9-(2-pyridinylmethoxy)-; 2-(1,4-Dioxan-2-ylmethoxy)-9-(2-pyridinylmethoxy)-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one. Grade: ≥95%. CAS No. 1445846-30-9. Molecular formula: C23H23N3O5. Mole weight: 421.45. | |
| G-Protein antagonist peptide acetate | G-Protein antagonist peptide is a competitive and reversible inhibitor of M2 muscarinic cholinergic receptors. G-Protein antagonist peptide inhibits M2 muscarinic receptor activation of Gi or Go and suppresses Gs activation by β-adrenoceptors. Synonyms: GPAnt-2 acetate; G Protein Antagonist acetate. Molecular formula: C59H68N12O11S. Mole weight: 1153.33. | |
| GPRP acetate | GPRP acetate, a fibrinogen-related peptide, inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa). Synonyms: Pefa 6003; Pefabloc FG; GPRP.CH3CO2H; glycyl-L-prolyl-L-arginyl-L-proline acetic acid; (S)-1-((S)-2-((S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxylic acid acetate; H-Gly-Pro-Arg-Pro-OH acetate. Grade: ≥95%. CAS No. 157009-81-9. Molecular formula: C18H31N7O5.C2H4O2. Mole weight: 485.53. | |
| GPS491 | GPS491 (EC50 = 0.47 μM) inhibits the expression of HIV-1 structural protein Gag, changes the accumulation of HIV-1 RNA, reduces the abundance of RNAs encoding the structural proteins, and increases the level of viral RNAs encoding the regulatory proteins. Synonyms: 2-(trifluoromethyl)-N-(6-(trifluoromethyl)benzo[d]thiazol-2-yl)thiazole-5-carboxamide. Grade: ≥98%. CAS No. 2655502-29-5. Molecular formula: C13H5F6N3OS2. Mole weight: 397.32. | |
| GPX100 | GPX-100 is an analogue of the anthracycline antineoplastic antibiotic doxorubicin. GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. Synonyms: Epirubicin Impurity 1; 13-Deoxyepirubicin; GPX 100; GPX-100; 13-deoxy-doxorubicin; (1S,3R)-3,5,12-Trihydroxy-3-(2-hydroxyethyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranoside; 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyethyl)-1-methoxy-, (8R,10S)-. Grade: ≥95%. CAS No. 952648-77-0. Molecular formula: C27H31NO10. Mole weight: 529.54. | |
| GPX150 | GPX-150 is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis. Synonyms: GPX 150; GPX-150; 5(8H)-Naphthacenone, 10-((3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranosyl)oxy)-7,9,10,12-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyethyl)-12-imino-1-methoxy-, (8R,10S)-. CAS No. 236095-29-7. Molecular formula: C27H32N2O9. Mole weight: 528.56. | |
| GPX4-IN-3 | GPX4-IN-3 is an effective inhibitor of glutathione peroxidase 4 (GPX4) and can be used as a selective ferroptosis inducer. It shows 71.7% inhibition for GPX4 with 1 μM. Synonyms: NSC-835419; 2-(benzo[b]thiophen-3-yl)-2-(2-chloro-N-(4-(oxazol-5-yl)phenyl)acetamido)-N-phenethylacetamide. Grade: ≥95%. Molecular formula: C29H24ClN3O3S. Mole weight: 530.04. | |
| GQ-16 | GQ-16 is an effective and partial agonist for peroxisome proliferator-activated receptor γ (PPARγ) (Ki = 160 nM). It does not activate PPARα, PPARβ/δ, or RXRα. Synonyms: 5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione. Grade: ≥98%. CAS No. 870554-67-9. Molecular formula: C19H16BrNO3S. Mole weight: 418.3. | |
| GQ1b-Ganglioside | GQ1b-Ganglioside is a vital biomedical product utilized for its neuroprotective properties. This compound acts as a crucial element in the treatment of various neurological disorders, including Guillain-Barré syndrome and Miller Fisher syndrome. Synonyms: Tetrasialoganglioside 1b; Ganglioside GQ1b; GQ1b. CAS No. 68652-37-9. | |
| GQ3-Oligosaccharide | GQ3-Oligosaccharide is an extraordinary bioactive compound employed in the research of neurodegenerative ailments, showcasing remarkable neuroprotective attributes. GQ3-Oligosaccharide actively contributes to the diminution of oxidative stress and inflammation, thereby facilitating the augmentation of neuronal viability and efficacious functioning. Synonyms: Neu5Aca2-8Neu5Aca2-8Neu5Acb2-8Neu5Aca2-3Galb1-4Glc. Molecular formula: C56H86N4O43Na4. Mole weight: 1595.24. | |
| GR103545 | GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR). Synonyms: GR-103545 fumarate; (R)-Methyl 4-(2-(3,4-dichlorophenyl)acetyl)-3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate fumarate; (R)-(-)-GR103545 fumarate. CAS No. 126766-43-6. Molecular formula: C23H29Cl2N3O7. Mole weight: 530.40. | |
| GR 103691 | GR 103691 is a potent dopamine D3 receptor antagonist. Uses: Dopamine antagonists. Synonyms: GR 103691; GR103691; GR-103691; 4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1'-biphenyl]-4-carboxamide. Grade: 99%. CAS No. 162408-66-4. Molecular formula: C30H35N3O3. Mole weight: 485.62. | |
| GR 113808 | GR 113808 is a potent and selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, Kd=0.15 nM for binding to cloned human 5-HT4 receptors). GR 113808 displays > 300-fold selectivity for 5-HT4 over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. Uses: Serotonin antagonists. Synonyms: GR 113808; GR113808; GR-113808. 1-methyl-1H-indole-3-carboxylic acid, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester. Grade: ≥98% by HPLC. CAS No. 144625-51-4. Molecular formula: C19H27N3O4S. Mole weight: 393.5. | |
| GR 125487-d3 sulfamate | GR 125487-d3 sulfamate is a deuterated salt form of GR 125487, which is a potent 5-HT4 receptor antagonist used for the treatment of gastrointestinal motility. Synonyms: 5-Fluoro-2-methoxy-d3-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate. Grade: 96% by HPLC; 99% atom D. Molecular formula: C19H23D3FN3O5S.H2NSO3H. Mole weight: 527.6. | |
| GR 125487 sulfamate | GR 125487, a potent and selective 5-HT4 antagonist, is used in many biological assays to cross confirm the 5-HT4R agonist's activity. Synonyms: GR 125487 sulfamate; GR 125487; GR125487; GR-125487. 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate. Grade: ≥97% by HPLC. CAS No. 859502-43-5. Molecular formula: C19H26FN3O5S.H2NSO3H. Mole weight: 524.58. | |
| GR-125743 | GR-125743 is a novel 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. It is used for the research of Parkinson's disease and cardiovascular diseases. Synonyms: N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-3-methyl-4-(pyridin-4-yl)benzamide; GR 125743. Grade: >99%. CAS No. 148547-33-5. Molecular formula: C25H28N4O2. Mole weight: 416.52. | |
| GR 127935 | GR 127935 is a potent and selective 5-HT1B/1D receptor antagonist (pKi = 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors), exhibiting >100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Uses: Serotonin antagonists. Synonyms: [1,1'-Biphenyl]-4-carboxamide, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-; N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-carboxamide; GR127935; GR-127935. Grade: ≥95%. CAS No. 148672-13-3. Molecular formula: C29H31N5O3. Mole weight: 497.59. | |
| GR 127935 hydrochloride | GR 127935 hydrochloride is a potent and selective 5-HT1B/1D receptor antagonist (pKi = 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors), exhibiting > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Synonyms: [1,1'-Biphenyl]-4-carboxamide, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-, hydrochloride (1:1); [1,1'-Biphenyl]-4-carboxamide, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-, monohydrochloride; N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-carboxamide hydrochloride; GR127935 hydrochloride; GR-127935 hydrochloride. Grade: ≥99% by HPLC. CAS No. 148642-42-6. Molecular formula: C29H31N5O3.HCl. Mole weight: 534.06. | |
| GR 135531 | GR 135531 is a high affinity agonist of MT3 melatonin receptors, with low affinity for MT1 and MT2 melatonin receptors. GR 135531 can be used to discriminate between the melatonin receptor subtypes. Synonyms: GR 135531; GR135531; GR-1355315-Methoxycarbonylamino-N-acetyltryptamine; 5-MCA-NAT; methyl N-[3-(2-acetamidoethyl)-1H-indol-5-yl]carbamate. Grade: ≥97% by HPLC. CAS No. 190277-13-5. Molecular formula: C14H17N3O3. Mole weight: 275.31. | |
| GR 144053 trihydrochloride | GR 144053 trihydrochloride is a potent and selective orally bioactive platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). GR 144053 potently inhibits thrombus formation in vivo. Synonyms: GR 144053; GR-144053; GR144053; GR 144053 trihydrochloride. 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid trihydrochloride. Grade: ≥99% by HPLC. CAS No. 1215333-48-4. Molecular formula: C18H27N5O2.3HCl. Mole weight: 454.83. | |
| GR 159897 | GR 159897 is a potent and selective neurokinin NK2 receptor antagonist. GR 159897 competes for binding of [3H]GR100679 to hNK2-transfected CHO cells (pKi = 9.5). Study shows that GR 159897 inhibits NK2 receptor-mediated contraction of guinea pig trachea. Synonyms: GR 159897; GR159897; GR-159897; 5-Fluoro-3-[2-[4-methoxy-4-[[(R)-phenylsulphinyl]methyl]-1-piperidinyl]ethyl]-1H-indole. Grade: ≥97% by HPLC. CAS No. 158848-32-9. Molecular formula: C23H27FN2O2S. Mole weight: 414.54. | |
| GR 203040 | GR 203040 is a selective NK1 receptor antagonist with high affinity. GR 203040 potently inhibits substance P binding to NK1 receptors (pKi = 10.1 to 10.5). Synonyms: (2S,3S)-N-[[2-Methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride. Grade: ≥98% by HPLC. CAS No. 168398-02-5. Molecular formula: C20H24N6O·2HCl. Mole weight: 437.37. | |
| GR 46611 | GR 46611 is a 5-HT1D receptor agonist that may be beneficial for the treatment of migraine. 5-HT1D acts on the central nervous system. Synonyms: GR 46611; GR46611; GR-46611; 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide. CAS No. 185259-85-2. Molecular formula: C23H27N3O2. Mole weight: 377.49. | |
| GR 55562 dihydrochloride | GR 55562 dihydrochloride is a selective and competitive 5-HT1B (5-HT1Dβ) silent antagonist (pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors, respectively). Synonyms: GR 55562 dihydrochloride; GR-55562; GR55562; GR 55562. 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride. Grade: ≥98% by HPLC. CAS No. 159533-25-2. Molecular formula: C23H25N3O2.2HCl. Mole weight: 448.39. | |
| GR 64349 TFA | GR 64349 is a potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Molecular formula: C44H69F3N10O13S. Mole weight: 1035.13. | |
| GR 79236 | GR 79236, an effective Adenosine A1 receptor agonist, could probably be used as an anti-inflammatory agent. IC50: 3.1 nM(Ki). Uses: Gr 79236 is an effective adenosine a1 receptor agonist that could probably be used as an anti-inflammatory agent. Synonyms: GR79236; GR-79236; GR 79236. N-[(1S, trans)-2-Hydroxycyclopentyl]adenosine. Grade: 95%. CAS No. 124555-18-6. Molecular formula: C15H21N5O5. Mole weight: 351.36. | |
| GR 89696 fumarate | GR 89696 fumarate is a potent and selective κ-opioid agonist (IC50 = 0.04 nM) displaying anti-nociceptive and neuroprotective activity. Synonyms: GR 89696 fumarate; GR 89696; GR89696; GR-89696. 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate. Grade: ≥99% by HPLC. CAS No. 126766-32-3. Molecular formula: C19H25Cl2N3O3.C4H4O4. Mole weight: 530.4. | |
| GR 94800 TFA | GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively. Molecular formula: C51H62F3N9O10. Mole weight: 1018.08. | |
| GRA Ex-25 | GRA Ex-25 is an orally active human glucagon receptor antagonist in a transgenic murine pharmacodynamic model, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. GCGR has evolved as an attractive therapeutic target for the treatment of type II diabetes mellitus. Synonyms: 3-(4-((1-(4-(tert-butyl)cyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid; GRA Ex-25; GRA Ex 25; GRA Ex25; GRAEx-25; GRAEx 25; GRAEx25. CAS No. 307983-31-9. Molecular formula: C29H36F3N3O5. Mole weight: 563.61. | |
| Granisetron | Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medull. Uses: Granisetron is an antagonist of serptpmom 5-ht3 receptor and could be used to relieve the nausea and vomiting symptom after receving chemotherapy by decreasing the activity of the vagus nerve. Synonyms: 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide; 1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, endo-; BRL 43694. Grade: > 95%. CAS No. 109889-09-0. Molecular formula: C18H24N4O. Mole weight: 312.42. | |
| Granisetron hydroChloride | Granisetron HCl is a serotonin 5-HT3 receptor antagonist. Grade: >98%. CAS No. 107007-99-8. Molecular formula: C18H24N4O.HCl. Mole weight: 348.87. | |
| Granisetron Impurity 1 | Granisetron Impurity 1 is an impurity of Granisetron. Synonyms: 1-Methyl-1H-Indazole-3-Carboxylic Acid Anhydride; 1-Methyl-1H-indazole-3-carboxylic Acid 3,3'-Anhydride. Grade: > 95%. CAS No. 1363173-34-5. Molecular formula: C18H4N4O3. Mole weight: 334.34. | |
| Granisetron Impurity B | Granisetron Impurity B has 5-HT antagonist activity. Synonyms: N-[(1R,3r,5S)-9-Methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide; N-[(3-endo)-9-Methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide; 1-Desmethyl Granisetron; endo-N-(9-Methyl-9-azabicyclo[3.3.1]non-3-yl)-1H-indazole-3-carboxamide. Grade: > 95%. CAS No. 107007-95-4. Molecular formula: C17H22N4O. Mole weight: 298.39. | |
| Granisetron Impurity C HCl | Granisetron Impurity C HCl. Grade: > 95%. CAS No. 1364645-74-8. Molecular formula: C17H23N4OCl. Mole weight: 334.85. | |
| Granotapide | Granotapide is used as an antihyperlipidaemic drug candidate. Uses: Granotapide is used as an antihyperlipidaemic drug candidate. Synonyms: JTT130; JTT 130; JTT-130; 2-[[3-(Dimethylcarbamoyl)-4-[[4'-(trifluoromethyl)biphenyl-2-yl]carbonylamino]phenyl]acetoxymethyl]-2-phenylmalonic acid diethyl ester. Grade: 98%. CAS No. 594842-13-4. Molecular formula: C39H37F3N2O8. Mole weight: 718.73. | |
| Grapiprant (CJ-023423) | Grapiprant, also known as CJ-023,423, RQ-00000007 and AAT-007, is a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties. Synonyms: CJ-023423; CJ 023423; CJ023423; CAS#415903-37-6; RQ-00000007; RQ 00000007; RQ00000007; AAT-007; AAT007; AAT 007; Grapiprant. Grade: 98%. CAS No. 415903-37-6. Molecular formula: C26H29N5O3S. Mole weight: 491.61. | |
| Grepafloxacin | Grepafloxacin is a quinoline antibacterial agent used to treat various bacterial infections. Uses: Antibacterial agent. Synonyms: Raxar; 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid. CAS No. 119914-60-2. Molecular formula: C19H22FN3O3. Mole weight: 359.401. | |
| Grepafloxacin Hydrochloride | The hydrochloride salt form of Grepafloxacin, a fluoroquinolone derivative, has been found to be a Type II DNA topoisomerase inhibitor and was once studied as an antibacterial agent. Synonyms: GREPAFLOXACIN HCL; OPC-17116; OPC 17116; OPC17116; 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride (1:1); Grepafloxacin hydrochloride; D02178; Gpfx; Grepafloxacin hydrochloride (jan/usan); Raxar; Raxar (tn). Grade: 98%. CAS No. 161967-81-3. Molecular formula: C19H22FN3O3.HCl. Mole weight: 395.86. | |
| Gresonitamab | Gresonitamab is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody that targets tumor-associated antigen (TAA) claudin. Synonyms: AMG-910; AMG 910; AMG910. Grade: 95%. CAS No. 2413817-97-5. | |
| GRI 977143 | GRI 977143 is a selective and non-lipid agonist of lysophosphatidic acid 2 (LPA2) receptor (EC50 = 3.3 μM) exhibiting no activity for other LPA GPCRs at concentrations up to 10 μM. GRI 977143 inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. It also activates ERK1/2 survival pathway. Synonyms: GRI977143; GRI-977143; GRI 977143; 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid. Grade: ≥98% by HPLC. CAS No. 325850-81-5. Molecular formula: C22H17NO4S. Mole weight: 391.44. | |
| Griseofulvic Acid | Griseofulvic Acid is a newly metabolite of Griseofulvin. Synonyms: (1'S,6'R)-7-Chloro-4,6-dimethoxy-6'-methyl-,Spiro[benzofuran-2(3H),1'-cyclohexane]-2',3,4'-trione; trans-7-Chloro-4,6-dimethoxy-6'-methylspiro[benzofuran-2(3H),1'- cyclohexane]-2',3,4'-trione; (+/-)-Griseofulvic Acid. Grade: > 95%. CAS No. 469-54-5. Molecular formula: C16H15ClO6. Mole weight: 338.75. | |
| Griseofulvin-d3 | Griseofulvin-d3 is a labelled analogue of Griseofulvin. Griseofulvin is an antifungal drug used for the treatment of dermatophytoses and some other infections caused by fungus. Synonyms: (1'S,6'R)-7-Chloro-2',4,6-trimethoxy-d3-6'-methyl-spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione; Amudane-d3; Fulcin-d3; Grisovi-d3; (+)-Griseofulvin-d3; Spirofulvin-d3; Sporostatin-d3; Xuanjing-d3. Grade: > 95%. CAS No. 1279033-22-5. Molecular formula: C17H14ClO6D3. Mole weight: 355.79. | |
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