BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| GNE-4997 | GNE-4997, a pyrazol derivative, has been found to be an ITK inhibitor that could have significant biological activities. Ki: 0.09 nM. Synonyms: GNE-4997; GNE-4997; GNE-4997; (4aS,5aR)-N-(1-((R)-((R)-1,1-dioxidotetrahydro-2H-thiopyran-2-yl)(phenyl)methyl)-1H-pyrazol-4-yl)-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide. Grade: 98%. CAS No. 1705602-02-3. Molecular formula: C25H27F2N5O3S. Mole weight: 515.58. |  |
| GNE-616 | GNE-616 is a potent selective inhibitor of Nav1.7, with potential for the treatment of chronic pain. Synonyms: GNE616. Grade: 98%. CAS No. 2349371-81-7. Molecular formula: C24H23F4N5O3S. Mole weight: 537.53. | |
| GNE-617 | GNE-617 is a novel and specific Nampt inhibitor with an IC50 of 18.9 nM in A549 cell. Synonyms: GNE-617; GNE 617; GNE617. Grade: >98%. CAS No. 1362154-70-8. Molecular formula: C21H15F2N3O3S. Mole weight: 427.42. | |
| GNE-6468 | GNE-6468, an imidazopyrimidine derivative, has been found to be a RORc inverse agonist that could be more effective than other members and be significant in studying the biological activities of RORC. Synonyms: GNE-6468; GNE 6468; GNE6468; 4-(6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl)-2-hydroxybenzoic acid. Grade: 98%. CAS No. 1677668-27-7. Molecular formula: C23H16ClN3O4. Mole weight: 433.85. | |
| GNE-6776 | GNE-6776 is a potent and non-covalent USP7 inhibitor with IC50 of 1.34 uM. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways, and induces tumor cell death. Synonyms: GNE 6776; GNE-6776; GNE6776; 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2-carboxamide. Grade: 98%. CAS No. 2009273-71-4. Molecular formula: C20H20N4O2. Mole weight: 348.406. | |
| GNE684 | GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1). Synonyms: (s)-N-((s)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1h-pyrido[3,4-b]azepin-3-yl)-5-phenyl-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide. Molecular formula: C23H24N6O3. Mole weight: 432.48. | |
| GNE-781 | GNE-781 is a potent, selective and orally active bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). GNE-781 exhibits antitumor activity in an AML tumor model and was also shown to decrease Foxp3 transcript levels in a dose dependent manner. Synonyms: GNE 781; GNE781. CAS No. 1936422-33-1. Molecular formula: C27H33F2N7O2. Mole weight: 525.59. | |
| GNE-7915 | GNE-7915 is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM. Synonyms: GNE7915; GNE 7915; GNE-7915. CAS No. 1351761-44-8. Molecular formula: C19H21F4N5O3. Mole weight: 443.403. | |
| GNE-7915 tosylate | GNE-7915 tosylate is a potent, selective and brain-penetrant LRRK2 inhibitor with an IC50 of 9 nM. Synonyms: (4-{[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino}-2-fluoro-5-methoxyphenyl)(4-morpholinyl)methanone 4-methylbenzenesulfonate (1:1); Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-, 4-methylbenzenesulfonate (1:1). Grade: ≥95%. CAS No. 2070015-00-6. Molecular formula: C26H29F4N5O6S. Mole weight: 615.60. | |
| GNE-8505 | GNE-8505 is an orally available dual leucine zipper kinase (DLK) inhibitor. Synonyms: example 152 [WO2014111496]. CAS No. 1620573-48-9. Molecular formula: C21H24F3N5O. Mole weight: 419.44. | |
| GNE-8525 | This active molecular is a selective pan-TRK inhibitor. GNE-8525 shows potent antiproliferation activity (IC50 = 0.003 μM) and it shows in vivo antitumor efficacy in tumor xenograft model derived from the KM12 cell line. TRKA are believed to be the key oncogenic driver in many tumors including glioblastoma, melanoma and so on. Uses: Antitumor. Synonyms: GNF-8625; GNF 8625; GNF8625. (R)-1-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-[2,4'-bipyridin]-2'-yl)piperidin-4-ol. Grade: 98%. CAS No. 1196546-33-4. Molecular formula: C31H30FN7O. Mole weight: 535.63. | |
| GNE-900 | GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. In combination with chemotherapeutic agents, GNE-900 sustains ATR/ATM signaling, enhances DNA damage, and induces apoptotic cell death. GNE-900 has little single-agent activity in the absence of chemotherapy and does not grossly potentiate the cytotoxicity of gemcitabine in normal bone marrow cells. In vivo scheduling studies show that optimal administration of the ChK1 inhibitor requires a defined lag between gemcitabine and GNE-900 administration. Synonyms: GNE900; GNE 900; 3-(4-(Piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile; 6-cyano-3-(4-piperidin-1-ylmethyl-phenyl)-9H-dipyrido[2,3-b; 4',3'-d]pyrrole. Grade: 98%. CAS No. 1200126-26-6. Molecular formula: C23H21N5. Mole weight: 367.45. | |
| GNE 9278 | GNE 9278 is a positive allosteric modulator of NMDA receptors. GNE-9278 targets transmembrane domain (TMD) extracellular surface of agonist-bound NMDARs, stabilizing NMDARs in an activated state by slowing L-L-glu & gly off-rate. Synonyms: Benzenesulfonamide, 4-cyclohexyl-N-(1,7-dihydro-5-methyl-7-oxo-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-; GNE-9278; GNE9278; 4-cyclohexyl-N-(5-methyl-7-oxo-2-propyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide. Grade: ≥98% by HPLC. CAS No. 2315311-83-0. Molecular formula: C21H27N5O3S. Mole weight: 429.54. | |
| GNE-955 | GNE-955 is a potent and orally active pan Pim kinase inhibitor, with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively. Synonyms: (S)-1-(3-methoxy-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)piperidin-3-amine. CAS No. 1527523-39-2. Molecular formula: C22H24N8O. Mole weight: 416.48. | |
| GNE-9605 | GNE-9605 retained excellent predicted human metabolic stability when assayed in human liver microsomes and hepatocytes. In addition, no reversible or time-dependent inhibition of any of the major CYP isoforms was observed. The demonstrated metabolic stability, brain penetration across multiple species, and selectivity of these inhibitors support their use in preclinical efficacy and safety studies. Synonyms: GNE9605; GNE-9605; GNE 9605. Grade: 0.98. CAS No. 1536200-31-3. Molecular formula: C17H20ClF4N7O. Mole weight: 449.839. | |
| GNE-9815 | GNE-9815 is one of the most highly kinase-selective RAF inhibitors targeting KRAS mutant cancers via combination treatment. Synonyms: GNE9815; GNE 9815. CAS No. 2729996-45-4. Molecular formula: C26H22FN5O2. Mole weight: 455.48. | |
| GNE-9822 | GNE-9822, a pyrazole derivative, has been found to be a ITK inhibitor that could probably be effective in studies of some inflammatory disorders. Synonyms: GNE-9822; GNE 9822; GNE9822; (S)-N-[1-[3-(Dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl]-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide. Grade: 98%. CAS No. 1557232-32-2. Molecular formula: C24H32N6O. Mole weight: 420.56. | |
| GNE-987 | GNE-987, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, is used in PROTAC-Antibody Conjugate (PAC). GNE-987 shows picomolar activity of cell BRD4 degradation (DC50 = 0.03 nM for EOL-1 AML cell line), and binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50s = 4.7 and 4.4 nM, respectively). It combines a potent BET binder/inhibitor, a VHL binding fragment and a 10 methylene spacer moiety. Synonyms: 7-(3,5-Difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamide; N-[11-({7-(3,5-Difluoropyridin-2-yl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carbonyl}amino)undecanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide. Grade: ≥98%. CAS No. 2417371-71-0. Molecular formula: C56H67F2N9O8S2. Mole weight: 1096.31. | |
| GNF1331 | GNF1331 is a potent, selective and orally bioavailable porcupine (PORCN) inhibitor with IC50 value of 12 nM. It plays a critical role in multiple cancers, such as cutaneous squamous cell carcinoma (SCC), colorectal cancer and breast cancer. Uses: Gnf1331 plays a critical role in multiple cancers, such as cutaneous squamous cell carcinoma (scc), colorectal cancer and breast cancer. Synonyms: N-(6-methoxy-1,3-benzothiazol-2-yl)-2-[(4-propyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide; GNF-1331; GNF 1331; GNF1331. Grade: 98%. CAS No. 603101-22-0. Molecular formula: C20H20N6O2S2. Mole weight: 440.54. | |
| GNF179 | GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. Synonyms: GNF 179; GNF-179. Grade: >98%. CAS No. 1261114-01-5. Molecular formula: C22H23ClFN5O. Mole weight: 427.9. | |
| GNF179 Metabolite | GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. Synonyms: GNF 179 Metabolite; GNF-179 Metabolite. Grade: >98%. CAS No. 1310455-86-7. Molecular formula: C14H16FN3. Mole weight: 245.3. | |
| GNF179 Metabolite-13C2 | GNF179 Metabolite-13C2. Grade: > 95%. Molecular formula: C12H16FN3[13C]2. Mole weight: 247.28. | |
| GNF-2 | GNF-2 is a Bcr-Abl inhibitor that binds to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. Thus, it can selectively inhibit Bcr-Abl phosphorylation (IC50 = 267 nM) without affecting native c-Abl or a panel of 63 additional kinases. Synonyms: GNF2; GNF-2; GNF 2. Grade: 98.73%. CAS No. 778270-11-4. Molecular formula: C18H13F3N4O2. Mole weight: 374.32. | |
| GNF351 | GNF351 is a potent antagonist of aryl hydrocarbon receptor (AHR). GNF351 is capable of competing with the photoaffinity ligand for binding to the human AHR and has a relative affinity for the AHR similar to that of SR1. CAS No. 1227634-69-6. Molecular formula: C24H25N7. Mole weight: 411.50. | |
| GNF-5 | GNF-5 is the N-hydroxyethyl carboamide analog of GNF-2, a selective allosteric inhibitor of Bcr-Abl. GNF-5 demonstrates IC50 values of 4.52, 0.38, and 0.93 μM against Bcr-Abl mutants G250E, E255V, and M351T, respectively. Synonyms: GNF-5; GNF 5; GNF5. CAS No. 778277-15-9. Molecular formula: C20H17F3N4O3. Mole weight: 418.38. | |
| GNF 5837 | GNF 5837 is a potent and selective pan-Trk inhibitor that blocks tumor gowth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. GNF 5837 displays antiproliferative effects in cellular Ba/F3 assays with IC50 values of 7, 9 and 11 nM for cells expressing Tel-TrkC, Tel-TrkB and Tel-TrkA respectively. Synonyms: GNF5837; GNF-5837; GNF 5837. 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-[4-methyl-3-[[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]amino]phenyl]urea. CAS No. 1033769-28-6. Molecular formula: C28H21F4N5O2. Mole weight: 535.503. | |
| GNF-6231 | GNF-6231 is a potent porcupine inhibitor that blocks Wnt signaling. GNF-6231 exhibits potential antitumor properties via inhibition of aberrant Wnt signaling. Synonyms: [2,4'-Bipyridine]-5-acetamide, N-[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl-; N-[5-(4-Acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl[2,4'-bipyridine]-5-acetamide; GNF 6231; GNF6231; N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2'-fluoro-3-methyl-[2,4'-bipyridin]-5-yl)acetamide. Grade: >98%. CAS No. 1243245-18-2. Molecular formula: C24H25FN6O2. Mole weight: 448.49. | |
| GNF-7 | GNF-7 is a type-II T315I inhibitor. GNF-7 inhibits Ack1 and germinal center kinase (GCK). GNF-7 is among the first type-II inhibitors capable of inhibiting T315I to be described and will serve as a valuable lead to design the third generation Bcr-Abl kinase inhibitors. Uses: Protein kinase inhibitors. Synonyms: GNF7; GNF 7; N-(4-methyl-3-(1-methyl-7-((6-methylpyridin-3-yl)amino)-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)phenyl)-3-(trifluoromethyl)benzamide. Grade: 98%. CAS No. 839706-07-9. Molecular formula: C28H24F3N7O2. Mole weight: 547.54. | |
| GNF-8625 monopyridin-N-piperazine hydrochloride | GNF-8625 monopyridin-N-piperazine hydrochloride is a TRK inhibitor. (Extracted from the patent WO 2020038415 A1). Synonyms: TRKi-2; (R)-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)-3-(6-(piperazin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazine hydrochloride. CAS No. 2412055-62-8. Molecular formula: C25H27ClFN7. Mole weight: 479.98. | |
| G-NGA2 N-Glycan | G-NGA2 N-Glycanthe transformative compound engaging in protein modifications. It finds applications in studying glycosylation-related disorders and diseases. Synonyms: Monogalactosylated asialo, biantennary (G-NGA2); Monogalactosylated, asialo, bi-antennary N-linked glycan; Monogalactosylated, asialo, biantennary N-glycan (G-NGA2); O-2-(Acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-2)-O-alpha-D-mannopyranosyl-(1-6)-O-[O-beta-D-galactopyranosyl-(1-4)-O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-2)-alpha-D-mannopyranosyl-(1-3)]-O-beta-D-mannopyranosyl-(1-4)-O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-(acetylamino)-2-deoxy-D-glucose. Grade: ≥90%. CAS No. 103584-68-5. Molecular formula: C56H94N4O41. Mole weight: 1479.35. | |
| GnRH antagonist 2 | GnRH antagonist 2, a GnRH receptor antagonist, can be used in the study of endometriosis. Synonyms: Urea, N-[4-[7-[(2,6-difluorophenyl)methyl]-3-[(dimethylamino)methyl]-4,5,6,7-tetrahydro-5-(6-methoxy-3-pyridazinyl)-4,6-dioxo-2H-pyrazolo[3,4-d]pyrimidin-2-yl]phenyl]-N'-methoxy-. Grade: ≥98%. CAS No. 1709823-61-9. Molecular formula: C28H27F2N9O5. Mole weight: 607.57. | |
| GnRH Associated Peptide (GAP) (1-13), human | GnRH Associated Peptide (GAP) (1-13), human is a potent inhibitor of prolactin secretion and stimulates the release of gonadotropins. Active immunization with peptides corresponding to the GAP sequences can significantly increase prolactin secretion. Synonyms: L-Valine, L-α-aspartyl-L-alanyl-L-α-glutamyl-L-asparaginyl-L-leucyl-L-isoleucyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-α-glutamyl-L-isoleucyl-; L-α-Aspartyl-L-alanyl-L-α-glutamyl-L-asparaginyl-L-leucyl-L-isoleucyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-α-glutamyl-L-isoleucyl-L-valine; H-Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val-OH. Grade: 95%. CAS No. 100111-07-7. Molecular formula: C65H101N15O25. Mole weight: 1492.58. | |
| GnRH Associated Peptide (GAP) (1-13), human acetate | GnRH Associated Peptide (GAP) (1-13), human acetate is a potent inhibitor of prolactin secretion and stimulates the release of gonadotropins. Active immunization with peptides corresponding to the GAP sequences can significantly increase prolactin secretion. Synonyms: H-Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val-OH.CH3CO2H; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-asparagyl-L-leucyl-L-isoleucyl-L-alpha-aspartyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-alpha-glutamyl-L-isoleucyl-L-valine acetic acid. Grade: ≥95%. Molecular formula: C67H105N15O27. Mole weight: 1552.63. | |
| GnRH II trifluoroacetate salt | GnRH II is a peptide that is encoded by the GNRH2 gene in humans. It acts as an agonist of the GnRH receptor (GnRHR). Synonyms: Gonadotropin-releasing Hormone II; ?LHRH II; 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-histidylglycyl-L-tryptophyl-L-tyrosyl-L-prolyl-glycinamide, trifluoroacetate salt. Grade: ≥95%. Molecular formula: C60H69N17O13·xCF3COOH. Mole weight: 1236.30. | |
| GO-6976 | Go6976 is a potent PKC inhibitor with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively. It also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively). Synonyms: GO-6976; GO 6976; PD-406976; PD 406976; PD406976. Grade: >98%. CAS No. 136194-77-9. Molecular formula: C24H18N4O. Mole weight: 378.435. | |
| Go6983 | GO6983 is a potent protein kinase C (PKC) inhibitor. GO6893 displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Synonyms: Go6983, Go-6983; Go 6983; GO6983. Grade: >98%. CAS No. 133053-19-7. Molecular formula: C26H26N4O3. Mole weight: 442.519. | |
| Golgicide A | Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1. Golgicide A inhibited HSV-1 entry via beta-galactosidase reporter assay and impaired incoming virus transport to the nuclear periphery. Synonyms: GCA; (3aR,9bS)-rel-6,8-Difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-3H-cyclopenta[c]quinoline; 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)-. Grade: ≥98%. CAS No. 1139889-93-2. Molecular formula: C17H14F2N2. Mole weight: 284.30. | |
| Golgicide A-2 | Golgicide A-2, a Golgicide A (GCA) derivative, is the most active stereoisomer of golgicide A. Golgicide A-2 is a cis-Golgi ArfGEF GBF inhibitor with high selectivity and efficiency in killing An. stephensi larvae. It can be used for research on dengue virus-related diseases. Synonyms: GCA-2; 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aS,4R,9bR)-; (3aS,4R,9bR)-golgicide A; (3aS,4R,9bR)-6,8-Difluoro-4-(3-pyridinyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline. Grade: ≥95%. CAS No. 1394285-50-7. Molecular formula: C17H14F2N2. Mole weight: 284.30. | |
| Golidocitinib | Golidocitinib is a novel potent and selective janus kinase 1 (JAK1) inhibitor, with antineoplastic properties. Synonyms: (2R)-N-(3-{2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-1H-indol-7-yl)-2-(4-methylpiperazin-1-yl)propanamide; AZD-4205; AZD4205; AZD 4205; NSC801813; NSC-801813; 1-Piperazineacetamide, N-(3-(2-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-4-pyrimidinyl)-1H-indol-7-yl)-alpha,4-dimethyl-, (alphaR)-; JAK1 inhibitor 3; Golidocitinibum. Grade: ≥98%. CAS No. 2091134-68-6. Molecular formula: C25H31N9O2. Mole weight: 489.58. | |
| Golimumab | Golimumab is a monoclonal antibody used in the treatment of autoimmune diseases, particularly rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. Golimumab targets and inhibits tumor necrosis factor alpha (TNF-α), a cytokine involved in the inflammatory pathway that contributes to autoimmune diseases. By blocking TNF-α, golimumab helps to reduce inflammation and alleviate symptoms associated with these conditions. Synonyms: Immunoglobulin G1, anti-(human tumor necrosis factor α) (human monoclonal CNTO 148 γ1-chain), disulfide with human monoclonal CNTO 148 κ-chain, dimer; CNTO 148; rTNV148B; Simponi; Simponi aria; Symponi; TNV 148B. CAS No. 476181-74-5. | |
| Golotimod hydrochloride | Golotimod hydrochloride is a STAT3 signaling inhibitor, which is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). Synonyms: SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride; Golotimod (hydrochloride). Grade: 98%. Molecular formula: C16H20ClN3O5. Mole weight: 369.80. | |
| Golotimod TFA | Golotimod TFA is an immunomodulating peptide that has antimicrobial activity. Golotimod TFA inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Synonyms: SCV 07 TFA. Molecular formula: C18H20F3N3O7. Mole weight: 447.36. | |
| Golvatinib | golvatinib (also known as E7050) is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth, migration and angiogenesis. Synonyms: E7050; E-7050; E 7050; Golvatinib. CAS No. 928037-13-2. Molecular formula: C33H37F2N7O4. Mole weight: 633.701. | |
| (-)Gomisin L1 | (-)Gomisin L1 is an enigmatic natural compound sourced from Schisandra chinensis illuminating its remarkable attributes as a potent modulator in the research of inflammation, cancer, Alzheimer's disease and cardiovascular disorders. Synonyms: (-)-Gomisin L1; Gomisin L1; 82425-43-2; UNII-6HN2PJ55D76HN2PJ55D7. Grade: >98%. CAS No. 82425-43-2. Molecular formula: C22H26O6. Mole weight: 386.444. | |
| (+)Gomisin M2 | (+)Gomisin M2 is a lignan isolated and purified form fruits of Schizandra chinensis which is is utilized for antitussive and tonic purposes in Oriental medicine. Synonyms: Benzo[3,?4]?cycloocta[1,?2-f]?[1,?3]?benzodioxol-13-ol, 5,?6,?7,?8-tetrahydro-1,?2,?3-trimethoxy-6,?7-dimethyl-, (6S,?7R,?13aR)?-; Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-13-ol, 5,6,7,8-tetrahydro-1,2,3-trimethoxy-6,7-dimethyl-, stereoisomer; (6S,7R,13aR)-5,6,7,8-Tetrahydro-1,2,3-trimethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-13-ol; Gomisin M2. Grade: > 98%. CAS No. 82425-45-4. Molecular formula: C22H26O6. Mole weight: 386.44. | |
| Goralatide acetate | Goralatide is a physiological regulator of hematopoiesis and inhibits the entry into the S-phase of murine and human hematopoietic stem cells. Ac-SDKP is a physiological substrate of angiotensin I- converting enzyme (ACE). Synonyms: N-acetyl-Ser-Asp-Lys-Pro; Acetyl-serinyl-aspartyl-lysinyl-proline acetate. Grade: 98%. Molecular formula: C22H37N5O11. Mole weight: 547.56. | |
| Goserelin EP Impurity C | Goserelin EP Impurity C is an impurity of Goserelin, a luteinizing hormone-releasing hormone analog that mediates the release of gonadotropins. Goserelin can be used to treat prostate cancer and breast cancer. Synonyms: H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-D-Pro-NHNHCONH2; [9-D-proline]goserelin; (9-D-proline)goserelin. Molecular formula: C59H84N18O14. Mole weight: 1269.43. | |
| Goserelin EP Impurity D | Goserelin EP Impurity D is an impurity of Goserelin, a luteinizing hormone-releasing hormone analog that mediates the release of gonadotropins. Goserelin can be used to treat prostate cancer and breast cancer. Synonyms: H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-NHNHCONH2; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-N'-carbamoyl-L-argininehydrazide; des-9-L-proline-goserelin. Molecular formula: C54H77N17O13. Mole weight: 1172.32. | |
| Goserelin EP Impurity H | Goserelin EP Impurity H is an impurity of Goserelin, a luteinizing hormone-releasing hormone analog that mediates the release of gonadotropins. Goserelin can be used to treat prostate cancer and breast cancer. Synonyms: H-D-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNHCONH2; [1-(5-oxo-D-proline)]goserelin. Molecular formula: C59H84N18O14. Mole weight: 1269.43. | |
| Goserelin EP Impurity I | Goserelin EP Impurity I is an impurity of Goserelin, a luteinizing hormone-releasing hormone analog that mediates the release of gonadotropins. Goserelin can be used to treat prostate cancer and breast cancer. Synonyms: H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Pro-Pro-NHNHCONH2; endo-8a,8b-di-L-proline-goserelin. Molecular formula: C69H98N20O16. Mole weight: 1463.67. | |
| Goserelin EP Impurity J | Goserelin EP Impurity J is an impurity of Goserelin, a luteinizing hormone-releasing hormone analog that mediates the release of gonadotropins. Goserelin can be used to treat prostate cancer and breast cancer. Synonyms: H-Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Pro-NHNHCONH2; endo-8a-L-proline-goserelin. Molecular formula: C64H91N19O15. Mole weight: 1366.55. | |
| Goserelin EP Impurity K | Goserelin EP Impurity K is an impurity of Goserelin, a luteinizing hormone-releasing hormone analog that mediates the release of gonadotropins. Goserelin can be used to treat prostate cancer and breast cancer. Synonyms: H-Pyr-His-Trp-Ser(Ac)-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNHCONH2; L-pyroglutamyl-L-histidyl-L-tryptophyl-O-acetyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-N'-carbamoyl-L-prolinehydrazide; [4-(O-acetyl-L-serine)]goserelin. Molecular formula: C61H86N18O15. Mole weight: 1311.47. | |
| GoSlo-SR-5-69 | GoSlo-SR-5-69 is a potent activator of large conductance Ca2+-activated K+ (BK) channels, with an EC50 of 251 nM. CAS No. 1363419-31-1. Molecular formula: C24H19N2NaO5S. Mole weight: 470.47. | |
| Gosogliptin | Gosogliptin is a dipeptidyl peptidase IV (DPP-IV) inhibitor. But no development was reported about Phase-II for Type-2 diabetes mellitus. Uses: Type 2 diabetes mellitus. Synonyms: UNII-GI718UO477; PF-00734200; PF 00734200; PF00734200; PF-734200; PF 734200; PF734200; CHEMBL515387; (3,3-difluoropyrrolidin-1-yl)-[(2S,4S)-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrrolidin-2-yl]methanone; 89490-47-1(dihydrochloride). Grade: 98%. CAS No. 869490-23-3. Molecular formula: C17H24F2N6O. Mole weight: 366.42. | |
| Govorestat | Govorestat is an aldose reductase inhibitor developed for the treatment of galactosemia. Synonyms: AT-007; AT 007; AT007. Grade: 98% by HPLC. CAS No. 2170729-29-8. Molecular formula: C17H10F3N3O3S2. Mole weight: 425.4. | |
| GP 1a | GP 1a is a highly selective CB2 receptor inverse agonist (pEC50 = 7.1), which displays approximately 30-fold selectivity for CB2 receptors over CB1 receptors. Synonyms: N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide; 1-(2,4-dichlorophenyl)-6-methyl-N-(1-piperidinyl)-4H-indeno[1,2-c]pyrazole-3-carboxamide. Grade: ≥99% by HPLC. CAS No. 511532-96-0. Molecular formula: C23H22Cl2N4O. Mole weight: 441.35. | |
| GP 2a | GP 2a is a selective CB2 receptor agonist that also dispalys modest agonism at CB1 receptors with Ki values of 7.6 and 900 nM, respectively. Synonyms: N-Cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3-carboxamide. Grade: ≥99% by HPLC. CAS No. 919077-81-9. Molecular formula: C24H23Cl2N3O. Mole weight: 440.36. | |
| GP2G | GP2G is an extraordinary pharmaceutical, finding applications in studying numerous autoimmune afflictions encompassing rheumatoid arthritand multiple sclerosis. Its mechanism of action entails robust immunosuppression alongside notable anti-inflammatory properties. Synonyms: P1-(5'-Guanosyl)-P2-(5'-guanosyl)-diphosphate, Sodium salt. Grade: ≥ 95 % by HPLC. Molecular formula: C20H26N10O15P2(free acid). Mole weight: 708.43 (free acid). | |
| GP3G | GP3G is a kind of diguanosine polyphosphate, could be found in human plasma. Synonyms: G(5')ppp(5')G; P1-(Guanosyl) P3-(5'-(guanosyl))triphosphate. Grade: ≥ 95 % by HPLC. Molecular formula: C20H27N10O18P3. Mole weight: 788.41. | |
| GP4G | GP4G, a naturally occurring compound found in green tea and seaweed, is a multifunctional ingredient commonly employed as a dietary supplement and cosmetic product ingredient. Various investigations indicate its significant role in augmenting skin cell metabolism and safeguarding against ultraviolet radiation-induced harm. Moreover, studies exhibit the potential of GP4G in bolstering brain function and exercise performance. The compound is also a promising candidate in treating afflictions such as Alzheimer's disease and stroke. Synonyms: P1-(5'-Guanosyl)-P4-(5'-guanosyl)-tetraphosphate. Grade: ≥ 95 % by HPLC. Molecular formula: C20H28N10O21P4. Mole weight: 868.39. | |
| Gp4U | Gp4U is an innovative and groundbreaking biomedical compound, used for studying diverse malignancies such as breast, lung and colon cancer. Synonyms: P1- (5'- Guanosyl)- P4- (5'- uridyl)- tetraphosphate, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 79695-25-3. Molecular formula: C19H27N7O22P4 (free acid). Mole weight: 829.4 (free acid). | |
| GP531 | GP531 is a novel riboside with similar structural and anti-ischemic properties to the adenosine-regulating agent (ARA) acadesine. Synonyms: 5-amino-1-[(2R,3R,4S,5R)-5-[(benzylamino)methyl]-3,4-dihydroxyoxolan-2-yl]imidazole-4-carboxamide; 5-amino-1-beta-D-(5'-benzylamino-5'-deoxyribofuranosyl)imidazole-4-carboxamide; GP 531; GP-531; GP531. CAS No. 142344-87-4. Molecular formula: C16H21N5O4. Mole weight: 347.37. | |
| GpAp | GpAp is a synthetic linear dinucleotide not binding to the c-diGMP-I riboswitch. Synonyms: Guanylyl- (3' -≥ 5')- adenosine- 3'- O- phosphate, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 17332-08-0. Molecular formula: C20H26N10O14P2. Mole weight: 692.4. | |
| GPBAR1-IN-3 | GPBAR1-IN-3, a CysLT1R antagonist, is a selective GPBAR1 agonist with an EC50 of 0.17 μM. Synonyms: (S)-2-((3-(2-methylbutoxy)phenoxy)methyl)quinoline. Molecular formula: C21H23NO2. Mole weight: 321.41. | |
| GPBAR-A | GPBAR-A is a GPBA receptor agonist. GPBAR-A increases GLP-1 secretion from intestinal cultures. Synonyms: GPBAR-A; GPBAR A; GPBARA; 4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one. Grade: ≥98% by HPLC. CAS No. 877052-79-4. Molecular formula: C23H15F7N2O2. Mole weight: 484.37. | |
| GpCp | GpCp is an analogue of GDP and has been found to be hydrolytically stable. Synonyms: GMPCP; Guanosine-5'-[(α,β)-methyleno]diphosphate, Sodium salt. Grade: ≥ 95 % by HPLC. CAS No. 32381-15-0. Molecular formula: C11H14N5Na3O10P2. Mole weight: 507.20. | |
| GpCpp | GpCpp is an analogue of GTP and could be used as a stabilizer in some microtubule cryoelectron microscopy studies. Uses: Antiviral agents. Synonyms: GMPCPP; Guanosine-5'-[(α,β)-methyleno]triphosphate. Grade: ≥ 95 % by HPLC. CAS No. 14997-54-7. Molecular formula: C11H18N5O13P3. Mole weight: 521.21. | |
| GPI-15427 | GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment in the management of HNSCC. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: GPI 15427; GPI15427; 10-((4-Methylpiperazin-1-yl)methyl)chromeno(4,3,2-de)phthalazin-3(2H)-one. CAS No. 805242-85-7. Molecular formula: C20H20N4O2. Mole weight: 348.41. | |
| GPi 688 | GPi 688 is an allosteric glycogen phosphorylase inhibitor that inhibits glucagon-mediated hyperglycemia in the rat. Synonyms: GPi 688; GPi688; GPi-688; 2-Chloro-N-[1-[(2R)-2,3-dihydroxypropyl]-1,2,3,4-tetrahydro-2-oxo-3-quinolinyl]-6H-thieno[2,3-b]pyrrole-5-carboxamide. Grade: ≥99% by HPLC. CAS No. 918902-32-6. Molecular formula: C19H18ClN3O4S. Mole weight: 419.88. | |
| GPP 78 | GPP 78 is a potent inhibitor of Nicotinamide phosphoribosyltransferase (Nampt) with an IC50 value of 3 nM. Synonyms: CAY10618; NMPRTase Inhibitor; N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-1H-1,2,3-triazole-1-octanamide. Grade: ≥95%. CAS No. 1202580-59-3. Molecular formula: C27H29N5O. Mole weight: 439.6. | |
Our database is helping our users find suppliers everyday.
