BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| GSK3326595 | GSK3326595, also called as EPZ015938, is an orally available and specific inhibitor of protein arginine methyltransferase 5 (PRMT5) that potently inhibits tumor growth in vitro and in vivo in animal models and has entered clinical trials for the treatment of solid tumors and non-Hodgkin's lymphoma. Synonyms: GSK-3326595; GSK 3326595; GSK3326595; EPZ015938; EPZ 015938; EPZ-015938; 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide. CAS No. 1616392-22-3. Molecular formula: C24H32N6O3. Mole weight: 452.55. |  |
| GSK-3787 | GSK-3787 is a potent and selective ligand for PPARdelta with good pharmacokinetic properties. Synonyms: GSK-3787; GSK3787; GSK 3787. CAS No. 188591-46-0. Molecular formula: C15H12ClF3N2O3S. Mole weight: 392.78059. | |
| GSK-461364 | GSK-461364 is a Polo-like kinase 1 inhibitor, is also a small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Synonyms: GSK461364; GSK 461364; GSK-461364; GSK461364A; GSK 461364A; GSK-461364A. 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide. CAS No. 929095-18-1. Molecular formula: C27H28F3N5O2S. Mole weight: 543.609. | |
| GSK525762 | GSK525762A, also known as I-BET-762 and GSK525762, is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor GSK525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth. Synonyms: GSK525762; GSK525762; GSK525762; GSK525762A; GSK-525762A; GSK 525762A; I-BET-762; I-BET762; I-BET 762; molibresib. CAS No. 1260907-17-2. Molecular formula: C22H22ClN5O2. Mole weight: 423.9. | |
| GSK547 | GSK547 is a highly selective and potent RIP1 (RIPK1) inhibitor which displays 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK963. Synonyms: RIP1i. Grades: ≥98%. CAS No. 2226735-55-1. Molecular formula: C20H18F2N6O. Mole weight: 396.39. | |
| GSK-7975A | This active molecular is a calcium release-activated calcium modulator (ORAI1) inhibitor. GSK-7975A inhibited toxin-induced activation of ORAI1 and/or activation of Ca(2+) currents after Ca(2+) release in mouse and human pancreatic acinar cells. GSK-7975A may be used for the treatment of pancreatitis in the future. Uses: Pancreatitis. Synonyms: GSK-7975A; GSK 7975A; GSK7975A; GSK-7975; GSK 7975; GSK7975. SCHEMBL705705; AOB4124; CPYTVBALBFSXSH-UHFFFAOYSA-N; 2, 6-difluoro-N-[1-[[4-hydroxy-2- (trifluoromethyl) phenyl]methyl]pyrazol-3-yl]benzamide. Grades: 98%. CAS No. 1253186-56-9. Molecular formula: C18H12F5N3O2. Mole weight: 397.31. | |
| GSK-8573 | GSK-8573 is an inactive control of GSK-2801, which is a potent inhibitor of BAZ2A and BAZ2B bromodomains. Synonyms: GSK8573; GSK 8573; GSK-8573; 1-[1-(3-Methoxyphenyl)-7-propoxyindolizin-3-yl]ethanone. CAS No. 1693766-04-9. Molecular formula: C20H21NO3. Mole weight: 323.392. | |
| GSK-LSD1 2HCl | GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). Synonyms: GSK LSD1 2HCl; GSK-LSD1 Dihydrochloride. Grades: >98%. CAS No. 1431368-48-7. Molecular formula: C14H22Cl2N2. Mole weight: 289.24. | |
| GTS-21 dihydrochloride | GTS-21, also known as DMBX-A, is a derivative of the natural product anabaseine that acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7 subtypes, but activates only the α7 to any significant extent. Synonyms: GTS-21; GTS 21; GTS21; DMBX-A. Grades: 98%. CAS No. 156223-05-1. Molecular formula: C19H20N2O2.2HCl. Mole weight: 381.30. | |
| Guanfacine hydrochloride | Guanfacine, a selective agonist of α2A receptor, is a sympatholytic drug to treat attention deficit hyperactivity disorder (ADHD) and hypertension. It lowers both systolic and diastolic blood pressure. Synonyms: BS 100-141; Tenex; Estulic; Guanfacine HCl; N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride; N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide hydrochloride; N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, hydrochloride (1:1). Grades: 95%. CAS No. 29110-48-3. Molecular formula: C9H10Cl3N3O. Mole weight: 282.56. | |
| GW0742 | GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPAR&gamma. Synonyms: GW0742; GW-0742; GW 0742; GW0742X; GW-0742X; GW 0742X; GW610742; GW-610742; GW 610742. Grades: >98%. CAS No. 317318-84-6. Molecular formula: C21H17F4NO3S2. Mole weight: 471.49. | |
| GW1929 | A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays). Synonyms: GW 1929; GW-1929. Grades: >98%. CAS No. 196808-24-9. Molecular formula: C30H29N3O4. Mole weight: 495.57. | |
| GW3965 Hydrochloride | GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. Synonyms: GW3965 Hydrochloride; GW 3965 Hydrochloride; GW-3965 Hydrochloride. Grades: >98%. CAS No. 405911-17-3. Molecular formula: C33H31ClF3NO3.HCl. Mole weight: 618.51. | |
| GW4869 | GW4869 is a cell-permeable, specific and non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). Synonyms: (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide;dihydrochloride; GW 4869; GW-4869. CAS No. 6823-69-4. Molecular formula: C30H30Cl2N6O2. Mole weight: 577.5. | |
| GW 627368X | GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity (Ki values of 100 nM and 158 nM, respectively). Uses: A potent and selective competitive antagonist. Synonyms: GW627368X; GW 627368X; GW-627368X; GW627368; GW 627368; GW-627368. N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide; 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide. Grades: ≥96%. CAS No. 439288-66-1. Molecular formula: C30H28N2O6S. Mole weight: 544.62. | |
| GW842166X | GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Synonyms: GW-842166X; 842166X; 842166; GW-842166; GW842166X; GW842166; GW 842166X; GW 842166. Grades: >98%. CAS No. 666260-75-9. Molecular formula: C18H17Cl2F3N4O2. Mole weight: 449.25. | |
| GW9508 | GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, and stimulates insulin secretion in a glucose-sensitive manner. GW9508 is commonly used in the treatment of type 2 diabetes. Synonyms: GW9508; GW-9508; GW 9508; 3-(4-((3-Phenoxybenzyl)amino)phenyl)propanoic acid. Grades: > 98%. CAS No. 885101-89-3. Molecular formula: C22H21NO3. Mole weight: 347.414. | |
| GX-674 | GX-674 is a Nav1.7 antagonist in the aryl sulfonamide class with higher selectivity for Nav1.7 (IC50= 0.1nM) over other Nav subtypes. Nav1.7 is commonly expressed in olfactory epithelium, sympathetic ganglion, and dorsal root ganglion sensory neurons. GX-674 has the potential to alleviate extreme pains. Synonyms: GX-674; GX674;GX 674; 4-(2-(2-Amino-1H-benzo[d]imidazol-5-yl)-4-chlorophenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide. CAS No. 1432913-36-4. Molecular formula: C21H13ClF2N6O3S2. Mole weight: 534.94. | |
| GYY-4137 Morpholine salt | GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen sulfide(H2S) donor. It protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. It inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes. It exhibits potent anti-cancer activity. It exhibits vasodilator and antihypertensive activity in rats, in either the acute or chronic hypertension models. It does not influence vascular smooth muscle cell viability in culture. It also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. Uses: Gyy-4137 morpholine salt inhibits the inflammatory response. it exhibits potent anti-cancer activity. it exhibits vasodilator and antihypertensive activity. Synonyms: GYY4137; GYY-4137; GYY 4137; GYY 4137 morpholine salt; ZYJ1122; ZYJ 1122; ZYJ-1122. GYY4137 Morpholine salt;(4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine;ZYJ1122 morpholine salt;ZYJ-1122 morpholine salt. Grades: ≥95%. CAS No. 106740-09-4. Molecular formula: C15H25N2O3PS2. Mole weight: 376.47. | |
| Halobetasol | Halobetasol is a corticosteroid, an anti-inflammatory drug that is used to treat various dermatological conditions which mainly consist of various forms of psoriasis. Uses: Vasoconstrictor agents. Synonyms: Ulobetasol; (6α,11β,16β)-21-chloro-6,9-difluoro-11,17-dihydroxy-16-methyl-Pregna-1,4-diene-3,20-dione. Grades: 98%. CAS No. 98651-66-2. Molecular formula: C22H27ClF2O4. Mole weight: 428.90. | |
| Halofuginone | Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. Uses: Semisynthetic quinazolinone alkaloid anticoccidial. Synonyms: Halofuginone; Tempostatin; RU 19110; RU19110; RU-19110. Grades: > 95%. CAS No. 55837-20-2. Molecular formula: C16H17BrClN3O3. Mole weight: 414.684. | |
| Haloperidol Impurity D | An impurity of Haloperidol, an antipsychotic medicine that is used to treat schizophrenia. Synonyms: 4,4'-Bis[4-(p-chlorophenyl)-4-hydroxypiperidino]butyrophenone; 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-{4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]pphenyl}-1-butanon; Haloperidol Related Compound A. Grades: > 95%. CAS No. 67987-08-0. Molecular formula: C32H36Cl2N2O3. Mole weight: 567.56. | |
| HC-030031 | HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. Synonyms: HC-030031; HC 030031; HC030031. TOSLAB 829227. Grades: >98%. CAS No. 349085-38-7. Molecular formula: C18H21N5O3. Mole weight: 355.39. | |
| Hellebrigenin | Hellebrigenin is an anticancer agent that induces DNA damage, mitochondria collapse, cell cycle arrest and apoptosis. Synonyms: Bufotalidin; (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-trihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde. CAS No. 465-90-7. Molecular formula: C24H32O6. Mole weight: 416.514. | |
| Hexa-D-arginine | An inhibitor of furin. Furin is a ubiquitous subtilisin-like proprotein convertase. Synonyms: Furin Inhibitor II; H-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2; D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-argininamide. Grades: 98%. CAS No. 673202-67-0. Molecular formula: C36H75N25O6. Mole weight: 954.14. | |
| Hexanoyl Docetaxel Metabolite M4 | Hexanoyl Docetaxel Metabolite M4 is a metabolite of Docetaxel, which is a semisynthetic derivative of Paclitaxel used to treat a variety of cancers, including breast, head and neck, stomach, prostate, and non-small cell lung cancer. Synonyms: 3-Oxazolidinepropanoic acid, 5,5-dimethyl-2,4-dioxo-α-[(1-oxohexyl)oxy]-β-phenyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-; (2α, 5β, 7β, 10β, 13α)-4-Acetoxy-13-{[(2R, 3S)-3-(5, 5-dimethyl-2, 4-dioxo-1, 3-oxazolidin-3-yl)-2-(hexanoyloxy)-3-phenylpropanoyl]oxy}-1, 7, 10-trihydroxy-9-oxo-5, 20-epoxytax-11-en-2-yl benzoate. Molecular formula: C49H59NO16. Mole weight: 917.99. | |
| Hexanoyl Docetaxel Metabolites M1 and M3 (Mixture of Diastereomers) | Hexanoyl Docetaxel Metabolites M1 and M3 (Mixture of Diastereomers) are metabolites of Docetaxel, which is a semisynthetic derivative of Paclitaxel used to treat a variety of cancers, including breast, head and neck, stomach, prostate, and non-small cell lung cancer. Synonyms: 3-Oxazolidinepropanoic acid, 4-hydroxy-5,5-dimethyl-2-oxo-α-[(1-oxohexyl)oxy]-β-phenyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-; (2α, 5β, 7β, 10β, 13α)-4-Acetoxy-13-{[(2R, 3S)-2-(hexanoyloxy)-3-(4-hydroxy-5, 5-dimethyl-2-oxo-1, 3-oxazolidin-3-yl)-3-phenylpropanoyl]oxy}-1, 7, 10-trihydroxy-9-oxo-5, 20-epoxytax-11-en-2-yl benzoate. Molecular formula: C49H61NO16. Mole weight: 920.00. | |
| Hexyl N-[amino-(4-aminophenyl)methylidene]carbamate | An impurity of Dabigatran. Dabigatran is a very potent anticoagulant, showing that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. Synonyms: Des-(ethyl 3-(N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate Dabigatran Etexilate; Dabigatran Impurity 25. Grades: ≥95%. CAS No. 255706-13-9. Molecular formula: C14H21N3O2. Mole weight: 263.34. | |
| HG-9-91-01 | HG-9-91-01,a small molecule inhibitor that targets specificly salt-inducible kinase (SIKs) IC50: SIK1=0.92 nM; SIK2=6.6 nM; SIK3=9.6 nM. Synonyms: 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]ureaHG-9-91-01; HG-9-91-01; HG 9-91-01; HG9-91-01; HG99101; HG-99101; HG 99101; GTPL8049SCHEMBL15271960BDBM192712CS-1749HG-9-91-01 (1)1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiper. CAS No. 1456858-58-4. Molecular formula: C32H37N7O3. Mole weight: 567.68. | |
| H-Gly-Pro-Hyp-OH | A peptide inhibitor of dipeptidylpeptidase-IV (DPP-IV). Synonyms: glycyl-prolyl-hydroxyproline; Gly-L-Pro-L-t4Hyp-OH; L-Proline, glycyl-L-prolyl-4-hydroxy-, (4R)-. Grades: 95%. CAS No. 2239-67-0. Molecular formula: C12H19N3O5. Mole weight: 285.30. | |
| His(2)-AVP | His(2)-AVP is an impurity of Vasopressin, which is an antidiuretic hormone secreted from the posterior pituitary. Synonyms: His(2)-Vasopressin; H-Cys-His-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6); L-cysteinyl-L-histidyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-arginyl-glycinamide (1->6)-disulfide. Molecular formula: C46H65N15O12S2. Mole weight: 1058.21. | |
| HIV-1 TAT Protein Peptide | It is a cell-permeable peptide (CPP) derived from the HIV-1 tat protein transduction domain (PTD), which has been shown to promote the entry of nucleic acids into several cell types. Synonyms: HIV-1 Tat Protein (47-57); H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH; TAT (47-57); L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginine. Grades: 98%. CAS No. 191936-91-1. Molecular formula: C64H118N32O14. Mole weight: 1559.83. | |
| HMMNI | HMMNI is a metabolite of dimetridazole. Dimetridazole is an antibacterial and anticoccidial agent that is once widely used for the treatment of parasitic infections in livestock. Synonyms: 2-Hydroxymethyl-1-methyl-5-nitro-1H-imidazole; (1-Methyl-5-nitroimidazol-2-yl)methanol. CAS No. 936-05-0. Molecular formula: C5H7N3O3. Mole weight: 157.1. | |
| HMN-214 | HMN-214 is an oral prodrug of HMN-176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1, a serine/threonine kinase that regulates critical mitotic events. Synonyms: HMN-214; HMN 214. CAS No. 173529-46-9. Molecular formula: C22H20N2O5S. Mole weight: 424.471. | |
| Homatropine methylbromide | Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. Synonyms: Homatropine Methylbromide; Omatropina metilbromuro; 8-Methylhomatropinium bromide; Homatropine methobromide; Homatropine methyl bromide; AC1L1MZP; Methylhomatropine. Grades: >98%. CAS No. 80-49-9. Molecular formula: C17H24BrNO3. Mole weight: 370.28. | |
| HS-173 | HS-173 is a potent and selective PI3Kα inhibitor displaying anticancer activity. HS-173 was shown to induce apoptosis via arresting the cell cycle at the G2/M phase. It also decreases angiogenesis induced by VEGF. Synonyms: Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate; HS173; HS 173; HS-173. Grades: 98%. CAS No. 1276110-06-5. Molecular formula: C21H18N4O4S. Mole weight: 422.459. | |
| Humulone | Humulone, a phloroglucinol derivative with antioxidant activity, inhibits cyclooxygenase-2. Synonyms: (6S)-3,5,6-trihydroxy-2-(3-methylbutanoyl)-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dien-1-one. Grades: > 95%. CAS No. 26472-41-3. Molecular formula: C21H30O5. Mole weight: 362.47. | |
| hVEGF-IN-1 | hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity. Tumor bearing mice treated with hVEGF-IN-1 have an average tumor volume of less than 300 mm. The tumor weight in the presence of hVEGF-IN-1 reduces around 60.1% to a final weight of 0.18 g. No significant change in body weight is observed during the treatment. Synonyms: 1-Piperazinepropanamide, N-[2-[4-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-2-quinazolinyl]phenyl]-4-methyl. CAS No. 1637443-98-1. Molecular formula: C34H43N7O2. Mole weight: 581.75. | |
| Hydralazine HCl | Hydralazine HCl is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM. Uses: Antihypertensive agents; vasodilator agents. Synonyms: Hydralazine hydrochloride. Grades: >98%. CAS No. 304-20-1. Molecular formula: C8H8N4.HCl. Mole weight: 196.64. | |
| Hydrochlorothiazide | Hydrochlorothiazide is a carbonic anhydrase inhibitor used as a diuretic medication. Hydrochlorothiazide can be used to treat hypertension and fluid retention (edema). Synonyms: HCTZ. CAS No. 58-93-5. Molecular formula: C7H8ClN3O4S2. Mole weight: 297.7. | |
| Hydrochlorothiazide Impurity C | Cas No. 402824-96-8. | |
| Hydrocortisone Acetate EP impurity G | Synonyms: UNII-ABH947V8F4; Hydrocortisone 11,21-diacetate; Cortisol, 11,21-diacetate; ABH947V8F4; [2-[(8S,9S,10R,11S,13S,14S,17R)-11-acetyloxy-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate; 2-((8S,9S,10R,11S,13S,14S,17R)-11-Acetoxy-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; Hydrocortisone acetate impurity G [EP]; HYDROCORTISONE ACETATE IMPURITY G [EP IMPURITY]; 17-Hydroxy-3,20-dioxopregn-4-ene-11beta,21-diyl diacetate; 17-HYDROXY-3,20-DIOXOPREGN-4-ENE-11.BETA.,21-DIYL DIACETATE; Pregn-4-ene-3,20-dione, 11,21-bis(acetyloxy)-17-hydroxy-, (11beta)-; PREGN-4-ENE-3,20-DIONE, 11,21-BIS(ACETYLOXY)-17-HYDROXY-, (11.BETA.)-; 2-((8S,9S,10R,11S,13S,14S,17R)-11-Acetoxy-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethylacetate. Grades: > 95%. CAS No. 81968-66-3. Molecular formula: C25H34O7. Mole weight: 446.55. | |
| Hydrocortisone Impurity D | 6β-Hydroxy Cortisol is a metabolite of Cortisol. Synonyms: 6β-Hydroxy Cortisol; (6β,11β)-6,11,17,21-Tetrahydroxypregn-4-ene-3,20-dione; 6β,17-Dihydroxycorticosterone; 6β,11β,17α,21-Tetrahydroxypregn- 4-en-3,20-dione; NSC 76163. Grades: > 95%. CAS No. 53-35-0. Molecular formula: C21H30O6. Mole weight: 378.46. | |
| Hydrocortisone Impurity I | Grades: > 95%. CAS No. 103795-84-2. Molecular formula: C21H30O6. Mole weight: 378.47. | |
| Hydrocortisone Impurity M | 11-Epihydrocortisone is an isomer of Hydrocortisone, a glucocorticord which functions primarily to increase blood sugar through gluconeogenesis, suppression of immune system and aid in fat, protein and carbohydrate metabolism. Uses: Anti-inflammatory agents. Synonyms: 11-Epihydrocortisone; 11α,17,21-Trihydroxypregn-4-ene-3,20-dione; 11-Isocortisol; 11α,17,21-Trihydroxypregn-4-ene-3,20-dione; 11α,17,21-Trihydroxypregnen-4-en-3,20-dione; 11α,17α,21-Trihydroxy-4-pregnene-3,20-dione; 11α,17α,21-Trihydroxyprogesterone; 11α-. Grades: > 95%. CAS No. 566-35-8. Molecular formula: C21H30O5. Mole weight: 362.46. | |
| Hydrodolasetron | Hydrodolasetron, is the reduced form of Dolasetron, a specific serotonin (5HT3) receptor antagonist. Synonyms: 2,6-Methano-2H-quinolizine, 1H-indole-3-carboxylic acid deriv.; 1H-Indole-3-carboxylic Acid Octahydro-3-hydroxy-2,6-methano-2H-quinolizin-8-yl Ester. Grades: > 95%. CAS No. 127951-99-9. Molecular formula: C17H22N2O3. Mole weight: 326.39. | |
| Hydroxy Baclofen | Cas No. 1346603-21-1. | |
| Hydroxy Bosentan | Hydroxy Bosentan is a metabolite of Bosentan. Synonyms: 4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide; Ro 48-8634; Ro 48-5033. Grades: > 95%. CAS No. 253688-60-7. Molecular formula: C27H29N5O7S. Mole weight: 567.63. | |
| Hydroxy Cobicistat | Hydroxy Cobicistat is an impurity in commercial preparation of Cobicistat. Synonyms: (S)-2- ( (hydroxy ( ( (2- (2-hydroxypropan-2-yl)thiazol-4-yl)methyl) (methyl)amino)methylene)amino)-N- ( (2R, 5R)-5- ( (hydroxy (thiazol-5-ylmethoxy)methylene)amino)-1, 6-diphenylhexan-2-yl)-4-morpholinobutanimidic acid. Grades: > 95%. CAS No. 1051463-40-1. Molecular formula: C40H53N7O6S2. Mole weight: 792.02. | |
| Hydroxy Darunavir | Hydroxy Darunavir is a metabolite of Daranavir. Synonyms: N-[3-[[(4-aminophenyl)sulfonyl](2-hydroxy-2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid Hexahydrofuro[2,3-b]furan-3-yl Ester. Grades: > 95%. CAS No. 1130635-75-4. Molecular formula: C27H37N3O8S. Mole weight: 563.66. | |
| Hydroxy Ebastine | A metabolite of Ebastine. Synonyms: 4-[4-(Diphenylmethoxy)-1-piperidinyl]-1-[4-(2-hydroxy-1,1-dimethylethyl)phenyl]-1-butanone. Grades: > 95%. CAS No. 210686-41-2. Molecular formula: C32H39NO3. Mole weight: 485.67. | |
| Hydroxy Empagliflozin | Hydroxy Empagliflozin is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[hydroxy[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol; (2S,3R,4R,5S,6R)-2-(4-chloro-3-(hydroxy(4-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 2137418-13-2. Molecular formula: C23H27ClO8. Mole weight: 466.91. | |
| Hydroxy Flutamide | Hydroxyflutamide is an antiandrogen. It is the major active metabolite of flutamide found to inhibit the proliferation of estradiol-induced growth of MCF-7 breast cancer cells. It is an AR antagonist and is one of a few gold standard AR antagonists. Uses: Androgen antagonists. Synonyms: Hydroxyniphtholide; 2-Hydroxyflutamide; 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; Sch 16423; α,α,α-Trifluoro-2-methyl-4'-nitro-m- lactotoluidide. Grades: > 95%. CAS No. 52806-53-8. Molecular formula: C11H11F3N2O4. Mole weight: 292.22. | |
| Hydroxy Ivabradine | An impurity of Ivabradine, a medication used to reduce the risk of hospitalization for worsening heart failure in adult patients with stable, symptomatic chronic heart failure. Synonyms: 1,3,4,5-Tetrahydro-3-(3-hydroxypropyl)-7,8-dimethoxy-2H-3-benzazepin-2-one; 3-(3-Hydroxypropyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one. Grades: > 95%. CAS No. 1235547-07-5. Molecular formula: C15H21NO4. Mole weight: 279.34. | |
| Hydroxymethyl Dasatinib | Hydroxymethyl Dasatinib is an oxidative metabolite of Dasatinib (M24 metabolite), used in the treatment of cancers and immune diseases. Synonyms: N-[2-Chloro-6-(hydroxymethyl)phenyl]-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide. Grades: > 95%. CAS No. 910297-58-4. Molecular formula: C22H26ClN7O3S. Mole weight: 504. | |
| Hydroxymethyl Emtricitabine | Hydroxymethyl Emtricitabine is an impurity of Emtricitabine, which is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: 5-Fluoro-1-((2S,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-4-((hydroxymethyl)amino)-2(1H)-pyrimidinone. Molecular formula: C9H12FN3O4S. Mole weight: 277.27. | |
| Hyoscine Butylbromide Impurity G | A metabolite of N-Butylscopolammonium bromide. N-Butylscopolammonium bromide is a medication used to treat crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. Synonyms: (1α, 2β, 4β, 5α, 7β)-9-Butyl-9-methyl-7-[(1-oxo-2-phenyl-2-propenyl)oxy]-3-oxa-9-azoniatricyclo[3.3.1.02, 4]nonane Bromide; 3-Oxa-9-azatricyclo[3.3.1.02,4]nonane 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane Deriv.; Apobuscopan. Grades: > 95%. CAS No. 92714-23-3. Molecular formula: C21H28NO3. Br. Mole weight: 422.4. | |
| HZ-1157 | HZ-1157 is an inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease. Synonyms: HZ-1157; HZ 1157; HZ1157. Dengue Virus Inhibitor II; 5-tert-butoxyquinazoline-2,4-diamine; 5-(tert-Butoxy)quinazoline-2,4-diamine; 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-. Grades: 98.75%. CAS No. 1009734-33-1. Molecular formula: C12H16N4O. Mole weight: 232.287. | |
| IACS-010759 | IACS-010759 is an orally bioavailable inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targeting complex I of the electron transport chain (NADH ubiquinone oxidoreductase). Study showed that IACS-010759 induced AMPK activation leading to mTOR suppression which resulted in cell growth inhibition in AML cells. Synonyms: 5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole. Grades: ≥98%. CAS No. 1570496-34-2. Molecular formula: C25H25F3N6O4S. Mole weight: 562.57. | |
| IAXO-102 | IAXO-102 is a TLR4 antagonist that modulates non-hematopoietic TLR4 proinflammatory signalling and inhibits experimental abdominal aortic aneurysm (AAA) development. Synonyms: IAXO-102; 1115270-63-7; CID 25222900; (2R,3R,4S,5R,6S)-2-(aminomethyl)-6-methoxy-4,5-di(tetradecoxy)oxan-3-ol; CHEMBL493017; SCHEMBL20239315; EX-A3691; AKOS037648519; BS-14387; HY-125171; CS-0089755; D70080; Methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-|A-D-glucopyranoside. CAS No. 1115270-63-7. Molecular formula: C35H71NO5. Mole weight: 585.94. | |
| Ibandronate Sodium Monohydrate | Ibandronate (< 100 μM) inhibits growth of both prostate cancer cell lines (LNCaP and PC-3) in a dose dependent manner. Synonyms: BM-21.0955. Grades:>98%. CAS No. 138926-19-9. Molecular formula: C9H23NO7P2.Na.H2O. Mole weight: 360.23. | |
| Ibopamine Hydrochloride | Ibopamine Hydrochloride, the prodrug of epinine, is a sympathomimetic drug used in ophthalmology. It induces mydriasis. It acts as an agonist on Dopamine receptor D1 and α-adrenergic receptors and has been studied for the treatment of congestive heart failure. Synonyms: 2-Methylpropanoic Acid 1,1'-[4-[2-(Methylamino)ethyl]-1,2-phenylene] Ester Hydrochloride; 3,4-Di-O-isobutyrylepinine Hydrochloride; Inopamil; Scandine. Grades: ≥95%. CAS No. 75011-65-3. Molecular formula: C17H26ClNO4. Mole weight: 343.85. | |
| Ibrutinib Dimer | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: Ibrutinib impurity MDAEJ; 2-Propen-1-one, 1-[(3R)-3-[4-[[3-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-3-oxopropyl]amino]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-; 1-((R)-3-(4-((3-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-oxopropyl)amino)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Grades: ≥95%. CAS No. 2031255-23-7. Molecular formula: C50H48N12O4. Mole weight: 880.99. | |
| Ibrutinib Impurity HNEJ | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grades: ≥95%. Molecular formula: C49H46N12O4. Mole weight: 866.99. | |
| Ibrutinib Impurity IMYBJ | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grades: ≥95%. Molecular formula: C20H19N5O. Mole weight: 345.41. | |
| Ibrutinib Impurity JXBJ | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grades: ≥95%. Molecular formula: C26H26N6O2. Mole weight: 454.53. | |
| Ibrutinib Impurity MDDYH | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grades: ≥95%. CAS No. 2052279-49-7. Molecular formula: C25H24N6O3. Mole weight: 456.51. | |
| Ibrutinib Impurity SMSJ | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Grades: ≥95%. Molecular formula: C32H24N8O2. Mole weight: 552.60. | |
| Ibrutinib Methoxy Impurity | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3-methoxypropan-1-one; Ibrutinib impurity JYD. Grades: ≥95%. CAS No. 2031255-26-0. Molecular formula: C26H28N6O3. Mole weight: 472.55. | |
| Ibudilast | Ibudilast is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE) which has been marketed for treating asthma. It crosses the blood-brain barrier, is well tolerated, is active on oral administration, reduces glial activation and attenuates pain symptoms in diverse rat models of neuropathic pain. In addition, it enhances acute morphine analgesia and attenuates morphine tolerance and withdrawal. Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain. Synonyms: MN-166, MN166, MN 166, AV-411, AV 411, AV411, KC404; KC-404; KC 404; Ibudilast. Grades: >98%. CAS No. 50847-11-5. Molecular formula: C14H18N2O. Mole weight: 230.31. | |
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