BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| 9,10-Bis(phenylethynyl)anthracene | 9,10-Bis(phenylethynyl)anthracene is a reagent for chemiluminescence research. It is known to exert fluorescence properties due to its polycyclic aromatic hydrocarbon system and it is commonly used as an scintillator additive. Synonyms: Anthracene, 9,10-bis(phenylethynyl)-; BPEA. Grades: 98%. CAS No. 10075-85-1. Molecular formula: C30H18. Mole weight: 378.474. |  |
| 9,10-Dibutoxyanthracene | The compound, 9,10-Dibutoxyanthracene, serves as a primary constituent for biomedical research, facilitating the synthesis of assorted organic compounds. Furthermore, it serves as a probe in the study of molecular electronic devices, thus revealing tremendous potential in the field of scientific exploration. Synonyms: AK-97075; AK 97075; AK97075. CAS No. 76275-14-4. Molecular formula: C22H26O2. Mole weight: 322.44. | |
| 9,9-Bis(methoxymethyl)-9H-Fluorene | Synonyms: 9,9-bis(methoxymethyl)fluorene; 9,9-di(methoxymethyl)fluorene. CAS No. 182121-12-6. Molecular formula: C17H18O2. Mole weight: 254.32. | |
| 9-Acetylanthracene | 9-Acetylanthracene (CAS# 784-04-3) is a polycyclic aromatic hydrocarbon (PAH) with photo-induced toxicity. Biological studies have shown that 9-Acetylanthracene has plasmid curing activity. Synonyms: 1-(anthracen-9-yl)ethanone; 9-Anthryl methyl ketone. CAS No. 784-04-3. Molecular formula: C16H12O. Mole weight: 220.27. | |
| 9-Aminoacridine | 9-Aminoacridine is a highly fluorescent dye, an acridine analog. It is used clinically as a topical antiseptic and experimentally as a mutagen. It is an intracellular pH indicator and a DNA intercalating agent. Uses: 9-aminoacridine is used clinically as a topical antiseptic and experimentally as a mutagen. Synonyms: Aminoacridine; NSC 13000; NSC-13000; NSC13000; 10-Amino-5-azaanthracene;9AA;9-Acridinamine;9-Amino-acridin;Acridin-9-amine;Aminacrine. Grades: 98%. CAS No. 90-45-9. Molecular formula: C13H10N2. Mole weight: 194.23. | |
| 9-Aminominocycline sulfate | 9-Aminominocycline sulfate is an impurity of Tigecycline, which is a glycylcycline antibiotic used to treat infection by drug resistant bacteria such as Staphylococcus aureus (Staph aureus) and Acinetobacter baumannii. Synonyms: Tigecycline Intermediate; 9-Amino-minocycline sulfuric acid. Grades: 95%. CAS No. 149934-20-3. Molecular formula: C23H30N4O11S. Mole weight: 570.57. | |
| 9-Azido-Neu5DAz | 9-Azido-Neu5DAz is a synthetic imaging agent. Synonyms: (2R,4S,5R,6R)-6-[(1R,2R)-3-azido-1,2-dihydroxypropyl]-2,4-dihydroxy-5-[3-(3-methyldiazirin-3-yl)propanoylamino]oxane-2-carboxylic acid 9-Azido-Neu5DAz. CAS No. 1639411-87-2. Molecular formula: C14H22N6O8. Mole weight: 402.36. | |
| 9-Bromo-10-phenylanthracene | 9-Bromo-10-phenylanthracene (CAS# 23674-20-6 ) is a useful research chemical. Synonyms: Anthracene, 9-Bromo-10-phenyl; 9-Bromo-10-phenylanthracene. Grades: 98 %. CAS No. 23674-20-6. Molecular formula: C20H13Br. Mole weight: 333.22. | |
| 9-Bromononanoic acid | 9-Bromononanoic acid, an instrumental biochemical reagent, finds ubiquitous use in several industrial processes including the synthesis of pharmaceutical drugs. Known for its inhibitory properties against fatty acid synthase, its prowess extends to manufacturing surfactants, detergents while also being extensively used as a building block in organic synthesis. This acid's multifunctional attributes coupled with its incomparable industrial benefits are a testament to its quintessential role in modern chemistry. Synonyms: Nonanoic acid, 9-bromo-; 9-bromo-nonanoic acid; 9-bromo-n-nonanoic acid. CAS No. 41059-02-3. Molecular formula: C9H17BrO2. Mole weight: 237.13. | |
| 9-Desmethyl-alpha-Dihydro-Tetrabenazine | 9-Desmethyl-alpha-Dihydro-Tetrabenazine is one of Tetrabenazine derivatives. Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder. It is a monoamine-depleting and a dopamine-receptor-blocking drug and is an effective and safe drug for the treatment of a variety of hyperkinetic movement disorders. Synonyms: (+)-9-O-Desmethyl-a-dihydrotetrabenazine; 1H-Naphtho[2,3-c]pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-5,10-dioxo-1-propyl-,(1R,3S); Desoxyfrenolicin; (2R,3R,11bR)-9-O-desmethyldihydrotetrabenazine; (+)-deoxyfrenolicin; 1H-Naphtho(2,3-c)pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-5,10-dioxo-1-propyl-,(1R-trans); 9-o-Desmethyl-alpha-dihydrotetrabenazine; 3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2,9-diol. Grades: ≥95%. CAS No. 1065193-59-0. Molecular formula: C18H27NO3. Mole weight: 305.41. | |
| 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | 9-Ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, a promising therapeutic agent for the treatment of select neoplastic disorders, functions as a highly proficient suppressor of pathogenic kinase enzymes that exhibit heightened expression levels in malignant neoplastic cells. This mechanism of action, whereby key cellular signaling pathways are disrupted, culminates in the prevention of tumor growth and impairs the metastatic process. Grades: 95%. CAS No. 1256584-80-1. Molecular formula: C21H17IN2O. Mole weight: 440.28. | |
| 9-Keto Risperidone | An impurity of Paliperidone which is an active metabolite of RISPERIDONE and used as a second generation (atypical) antipsychotic agent. Synonyms: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-7,8-dihydro-2-methyl-4H-pyrido[1,2-a]pyrimidine-4,9(6H)-dione. Grades: > 95%. CAS No. 1189516-65-1. Molecular formula: C23H25FN4O3. Mole weight: 424.48. | |
| 9-Methoxycamptothecin | Methoxycamptothecin, 9- is extracted from the barks of Camptotheca acuminata Decne. Synonyms: (4S)-10-Methoxy-4α-ethyl-4β-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (4S)-4-Ethyl-4-hydroxy-10-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (4S)-4α-Ethyl-4-hydroxy-10-methoxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione; 11-Methoxycamptothecin. Grades: >98%. CAS No. 39026-92-1. Molecular formula: C21H18N2O5. | |
| 9-Methoxycanthin-6-one | 9-Methoxycanthin-6-one is a canthin-6-one alkaloid isolated from intact plant parts and callus cultures of Eurycoma longifolia (Tongkat Ali). It exhibits anti-tumor effects. Synonyms: 9-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one. CAS No. 74991-91-6. Molecular formula: C15H10N2O2. Mole weight: 250.25. | |
| 9-Methyldecanoic acid | 9-Methyldecanoic acid (CAS# 1119-63-7 ) is a useful research chemical. Synonyms: 9-methyl-decanoic acid; 9-Methylcapric acid. CAS No. 1119-63-7. Molecular formula: C11H22O2. Mole weight: 186.29. | |
| 9-methylidenefluorene | 9-Methylidenefluorene is an analog of 9-Methylfluorene; a compound that has been shown to be mutagenic in Salmonella typhimurium TA98 and TA100 in the presence of 9000 X g supernantant from Aroclor-induced rats. Synonyms: 9-Methylene-9H-fluorene; 9H-Fluorene, 9-Methylene-; Fluorenylidenemethane; 9-Methylene-fluorene. CAS No. 4425-82-5. Molecular formula: C14H10. Mole weight: 178.23. | |
| 9-Phenanthrenemethanol | 9-Phenanthrenemethanol, a well-known intermediate in organic synthesis, presents itself as a promising compound with its anti-inflammatory and analgesic properties. Its therapeutic potential is particularly notable in the management of pain and inflammatory diseases, such as arthritis, but further investigation in clinical settings is required to fully harness its benefits. Synonyms: phenanthren-9-ylmethanol; (9-Phenanthryl)methanol; 9-(Hydroxymethyl)phenanthrene; 9-Hydroxymethylphenanthrene; 9-Phenanthrenemethanol. Grades: 95%. CAS No. 4707-72-6. Molecular formula: C15H12O. Mole weight: 208.26. | |
| 9-Piperazine Levofloxacin | An impurity of Levofloxacin, which is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Synonyms: Levofloxacin EP Impurity I; (-)-(S)-10-Fluoro-2,3-dihydro-3-methyl-9-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid. Grades: > 95%. CAS No. 178912-62-4. Molecular formula: C18H20FN3O4. Mole weight: 361.38. | |
| [Ala17]-MCH | [Ala17]-MCH is a melanin-concentrating hormone receptor agonist with EC50 values of 17 and 54 nM at MCH1 and MCH2 receptors. Grades: ≥95% by HPLC. CAS No. 359784-84-2. Molecular formula: C97H155N29O26S4. Mole weight: 2271.71. | |
| α , α -Bis[4- (dimethylamino)phenyl]-4- (methylamino)-benzenemethanol | Bis[4- (dimethylamino)phenyl]-[4- (methylamino)phenyl]methanol is produced from degradation of methyl green. Synonyms: 4, 4'-Bis (dimethylamino)-4''- (methylamino)trityl alcohol; Benzenemethanol, a, a-bis[4- (dimethylamino)phenyl]-4- (methylamino)-. Grades: 90%. CAS No. 561-41-1. Molecular formula: C24H29N3O. Mole weight: 375.51. | |
| α-Amyloid Precursor Protein Modulator | α-Amyloid Precursor Protein Modulator is a cell-permeable protein kinase C (PKC) activator. It was shown to induce differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Synonyms: TPPB; alpha-APP Modulator; (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide. Grades: >98%. CAS No. 497259-23-1. Molecular formula: C27H30F3N3O3. Mole weight: 501.55. | |
| α-Cyclodextrin Hydrate Sulfate Sodium Salt | α-Cyclodextrin Hydrate Sulfate Sodium Salt is a cyclic oligosaccharide composed of a macrocyclic ring of glucose subunits. α-Cyclodextrin is a natural soluble dietary fiber. CAS No. 699020-02-5. Molecular formula: C36H60O30.xH2SO4.yH2O.zNa. | |
| α-D-Glucopyranosyl Fluoride | α-D-Glucopyranosyl Fluoride is a key compound used in biomedicine for synthesizing various fluorinated carbohydrates and glycoconjugates. It plays a vital role in the development of novel drugs, diagnostics, and vaccines targeting metabolic disorders, such as diabetes, by modulating carbohydrate metabolism pathways. Synonyms: alpha-D-Glucopyranosyl fluoride; 1-FLUORO-ALPHA-1-DEOXY-D-GLUCOSE. Grades: 98%. CAS No. 2106-10-7. Molecular formula: C6H11FO5. Mole weight: 182.15. | |
| α-(difluoromethyl)-DL-Arginine | α-(difluoromethyl)-DL-Arginine (DFMA) is an enzyme-activated, irreversible inhibitor of the arginine decarboxylases of E. coli (Ki = 800 μM), P. aeruginosa, and K. pneumoniae. Synonyms: DFMA; RMI 71897; DL-alpha-(Difluoromethyl)arginine; 2-Amino-2-(difluoromethyl)-5-guanidinopentanoic acid. Grades: ≥95%. CAS No. 69955-43-7. Molecular formula: C7H14F2N4O2. Mole weight: 224.2. | |
| (?)-(α)-Kainic Acid hydrate | A naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Synonyms: (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid hydrate. Grades: ≥98%. CAS No. 58002-62-3. Molecular formula: C10H15NO4·H2O. Mole weight: 231.2. | |
| α-Linolenic acid | α-Linolenic acid (ALA) is an omega-3 fatty acid that occurs as the glyceride in most drying oils. It has an inhibitory effect on prostaglandin thus reduces inflammation and the risk of certain chronic diseases. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: alpha-Linolenic acid; linolenic acid; linolenate; Octadeca-9Z,12Z,15Z-Trienoic acid; (Z,Z,Z)-9,12,15-Octadecatrienoic acid; 9,12,15-Octadecatrienic acid; 9,12,15-Octadecatrienoic acid; 9Z,12Z,15Z-Octadecatrienoic acid; alpha-LNN; all cis-9,12,15-Octadecatrienoic acid. Grades: >98%. CAS No. 463-40-1. Molecular formula: C18H30O2. Mole weight: 278.43. | |
| α-Melanocyte-Stimulating Hormone (MSH), amide | α-Melanocyte-Stimulating Hormone (MSH), is an endogenous melanocortin receptor agonist that results in the activation of adenylyl cyclase, with anti-inflammatory effect. Synonyms: CZEN-002; CZEN002; CZEN 002; α-MSH; α-MSH, amide; α-Melanotropin; α-Melanocyte stimulating hormone. Grades: 98%. CAS No. 581-05-5. Molecular formula: C77H109N21O19S. Mole weight: 1637.88. | |
| α-NETA | α-NETA is a stable, non-competitive, and slowly reversible inhibitor of choline acetyltransferase (ChAT) with IC50 value of 9 μM. It mildly inhibits cholinesterases and carnitine acetyltransferase. Synonyms: HY-124957; 2-Naphthoylethyltrimethylammonium. Grades: ≥97%. CAS No. 31059-54-8. Molecular formula: C16H20NO·I. Mole weight: 369.2. | |
| α-Tocopherol phosphate | Cas No. 38976-17-9. | |
| α-Tocotrienol | α-Tocotrienol is a form of vitamin E, a class of eight fat-soluble compounds. It was shown to induce apoptosis and inhibit proliferation, and down-regulate the fibroblast growth factor receptor-1 (FGFR1). Uses: Antioxidants. Synonyms: (2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol. CAS No. 58864-81-6. Molecular formula: C29H44O2. Mole weight: 424.7. | |
| α-Tricalcium phosphate | α-Tricalcium phosphate, a bioceramic material widely employed in biomedical industries, finds applications in bone grafting and tissue engineering. Due to its chemical similarity to natural bone, this material is especially suitable for repairing bone defects. In addition to providing structural support, it can promote bone cell proliferation and facilitate the integration of new bone tissue into the defect area, making it a promising alternative to traditional bone grafting materials. Synonyms: Alpha-tricalcium phosphate; Tricalcium phosphate. Molecular formula: Ca3(PO4)2. Mole weight: 310.18. | |
| (αZ)-2-Amino-α-[(1-carboxy-1-methylethoxy)imino]-4-thiazoleacetic Acid | (αZ)-2-Amino-α-[(1-carboxy-1-methylethoxy)imino]-4-thiazoleacetic Acid can be used in the synthesis of Aztreonam, a synthetic monocyclic β-lactam antibiotic. Synonyms: Aztreonam impurity 15. Grades: 95%. CAS No. 102507-85-7. Molecular formula: C9H11N3O5S. Mole weight: 273.26. | |
| (Aminomethylene)bisphosphonic acid | (Aminomethylene)bisphosphonic acid (CAS# 29712-28-5 ) is a useful research chemical. Synonyms: (aminomethylene)bisphosphonic acid; Phosphonic acid, (aminomethylene)bis-. Grades: 98 %. CAS No. 29712-28-5. Molecular formula: CH7NO6P2. Mole weight: 191.02. | |
| (Aminomethyl)phosphonic acid | Aminomethanephosphonic acid is a degradation product of the herbicide glyphosate. Synonyms: aminomethylphosphonic acid. Grades: 98 %. CAS No. 1066-51-9. Molecular formula: CH6NO3P. Mole weight: 111.04. | |
| (+/-)-Apremilast | (+/-)-Apremilast is the racemic form of Apremilast, an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4). Synonyms: Apremilast, (+/-)-; N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide; Acetamide, N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)-. CAS No. 253168-86-4. Molecular formula: C22H24N2O7S. Mole weight: 460.5. | |
| (-)-AS 115 | (-)-AS 115, an isomer of AS 115, is a potent and selective inactivator of KIAA1363. KIAA1363 is an enzyme that catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. Synonyms: (-)-AS 115; CHEMBL2069333; ()-AS 115; 2-Fluorophenyl- (2- ( ( (1R, 2S) -2- (butoxymethyl) cyclohexyl) methoxy) ethyl) carbamate; AS 115; AS115; BDBM50390508. Grades: ≥98%. CAS No. 926657-43-4. Molecular formula: C21H32FNO4. Mole weight: 381.5. | |
| B02 | B02 is a RAD51 inhibitor that inhibits the DNA strand exchange activity of humans RAD51 (IC50 = 27.4 μM) and enhances DOX sensitivity of MM cells. Uses: B02 is a rad51 inhibitor. Synonyms: B02; B-02; B 02; RAD51-IN-02; AC1MGVFT; CTK8E4385; MCULE-2747219395; 3-benzyl-2-(2-pyridin-3-ylethenyl)quinazolin-4-one. Grades: ≥98%. CAS No. 1290541-46-6. Molecular formula: C22H17N3O. Mole weight: 339.398. | |
| Baccatin III | Cas No. 27548-93-2. | |
| Bag-1 | Bag-1 is a novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist. Grades: 98%. CAS No. 1021937-07-4. Molecular formula: C22H27N3. Mole weight: 333.5. | |
| Bag-2 | Bag-2 is a new powerful non-peptide bombesin receptor subtype 3 (BRS-3) agonist. Synonyms: Bag-2; 1021936-34-4; CHEMBL1084942; 2-[4-[2-[5-(cyclopentylmethyl)-1H-imidazol-2-yl]ethyl]phenyl]benzoic acid[3H]bag-2. Grades: 98%. CAS No. 1021936-34-4. Molecular formula: C24H26N2O2. Mole weight: 374.5. | |
| (+)-Balanophonin | (+)-Balanophonin is a lignan isolated from the barks of Gmelina arborea and the seeds of Crataegus pinnatifida. Study indicates that (+)-Balanophonin inhibits the proliferation of OPM2 and RPMI-8226 cells. Synonyms: (2E)-3-[(2S,3R)-2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-5-benzofuranyl]-2-propenal. Grades: >98%. CAS No. 215319-47-4. Molecular formula: C20H20O6. Mole weight: 356.37. | |
| Baloxavir | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Synonyms: Baloxavir acid; BXA; Xofluza; S-033447. Grades: ≥98%. CAS No. 1985605-59-1. Molecular formula: C24H19F2N3O4S. Mole weight: 483.49. | |
| Baloxavir marboxil | Baloxavir marboxil is a first-in-class, one-dose oral medicine with a novel proposed mechanism of action that has demonstrated efficacy in a wide range of influenza viruses, including in vitro activity against oseltamivir-resistant strains and avian strains (H7N9, H5N1) in non-clinical studies. Baloxavir is a polymerase acidic, cap-dependent, endonuclease inhibitor that is indicated for the treatment of acute uncomplicated influenza in patients aged 12 years and older who have been symptomatic for no more than 48 hours. It blocks viral proliferation by binding to one of two endonuclease binding sites, inhibiting the initiation of mRNA synthesis for both influenza A and influenza B strains. Baloxavir can interact with polyvalent cation-containing products, which can decrease its plasma concentration. Synonyms: S-033188; HY-109025. Grades: ≥98%. CAS No. 1985606-14-1. Molecular formula: C27H23F2N3O7S. Mole weight: 571.55. | |
| Balsalazide | Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is a new 5-aminosalicylic acid (5-ASA) containing prodrug. It is approved for the treatment of mild-to-moderate active UC. It is also efficacious for the induction of remission in mild to moderate UC and has a favorable safety profile. Synonyms: Colazal; Giazo. Grades: >98%. CAS No. 80573-04-2. Molecular formula: C17H15N3O6. Mole weight: 357.32. | |
| BAM (8-22) | BAM (8-22) is an endogenous peptide agonist for the sensory neuron specific receptor (SNSR) (EC50 = 28 and 14 nM for SNSR3 and SNSR4, respectively). It exhibits spinal analgesic effects by interacting with NMDA receptors. BAM (8-22) displays no affinity for opioid receptors compared to BAM 22. Synonyms: Bovine Adrenal Medulla Peptide (8-22); H-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH; BAM-22P (8-22); L-valyl-glycyl-L-arginyl-L-prolyl-L-alpha-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl-glycine; BAM-15. Grades: ≥95%. CAS No. 412961-36-5. Molecular formula: C91H127N25O23S. Mole weight: 1971.22. | |
| Bamaquimast | Bamaquimast is an orally active inhibitor of proton pump with anti-inflammatory and antiasthmatic effects. Synonyms: Bamaquimast; F 10126; F-10126; F10126; L 0042; L-0042; L0042. 3-(3-oxo-4-propylquinoxalin-2-yl)propyl N-methylcarbamate. CAS No. 135779-82-7. Molecular formula: C16H21N3O3. Mole weight: 303.36. | |
| BAMB-4 | BAMB-4 is a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A((ITPKA). It exhibits the lowest inhibition frequency among the InsP3-Kinase inhibitors. It is a promising therapeutic approach in lung cancer therapy. Synonyms: Bamb-4; Bamb 4; Bamb4; ITPKA-IN-C14. Grades: >98%. CAS No. 891025-25-5. Molecular formula: C15H12N2O2. Mole weight: 252.27. | |
| Baohuoside V | Baohuoside V is extracted from the herbs of Epimedium brevicornum Maxim. Synonyms: 3-[[6-Deoxy-2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-mannopyranosyl]oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; Diphylloside B. Grades: >98%. CAS No. 118544-18-6. Molecular formula: C38H48O19. Mole weight: 808.8. | |
| Baohuoside VII | Baohuoside VII is a compound of the flavonoid class found in the herbs of Epimedium brevicornum Maxim. Synonyms: 3-[(2S,3R,4S,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one. Grades: >98%. CAS No. 119730-89-1. Molecular formula: C33H40O15. Mole weight: 676.668. | |
| BAR502 | BAR502 is a dual FXR and GPBAR1 agonist (IC50= 2 μM and 0.4 μM for FXR and GPBAR1, respectively). Synonyms: BAR-502; BAR 502; BAR502; (5S,8S,9R,10S,13R,14S,17R)-6-ethyl-17-(4-hydroxybutan-2-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol. CAS No. 1612191-86-2. Molecular formula: C25H44O3. Mole weight: 392.62. | |
| Bardoxolone | Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPAR&gamma. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events. Synonyms: CDDO; RTA 401; RTA401; RTA-401. Grades: >98%. CAS No. 218600-44-3. Molecular formula: C31H41NO4. Mole weight: 491.66. | |
| Bardoxolone methyl | Bardoxolone methyl (also known as "RTA 402" and "CDDO-methyl ester") is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. It is the most potent known inducer of the Nrf2 pathway to enter clinical development and works to suppress both oxidative stress and inflammation. Uses: A nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells; antioxidant inflammation modulator (aim); for the treatment of advanced chronic kidney disease (ckd) in type 2 diabetes mellitus patients. Synonyms: CDDO Methyl ester; CDDOMe; RTA 402; RTA-402; RTA402; TP-155; TP155; TP 155; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid methyl ester; bardoxolone methyl; CDDO-Me; methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate; (4aS,6aR,6bS,8aR,12aS,14bS)-Methyl 11-cyano-2, 2, 6a, 6b, 9, 9, 12a-heptamethyl-10, 14-dioxo-1, 2, 3, 4, 4a, 5, 6, 6a, 6b, 7, 8, 8a, 9, 10, 12a, 14, 14a, 14b-octadecahydropicene-4a-carboxylate. Grades: ≥ 98.0%. CAS No. 218600-53-4. Molecular formula: C32H43NO4. Mole weight: 505.70. | |
| Baricitinib | Baricitinib is a selective and orally bioactive inhibitor of JAK1 and JAK2. It has been approved by FDA for the treatment of rheumatoid arthritis (RA). Uses: The treatment of rheumatoid arthritis (ra). Synonyms: LY3009104; 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile; Olumiant. Grades: >98%. CAS No. 1187594-09-7. Molecular formula: C16H17N7O2S. Mole weight: 371.419. | |
| Bavachalcone | Bavachalcone inhibited osteoclast formation from precursor cells with the IC(50) of approximately 1.5 microg ml(-1). The activation of MEK, ERK, and Akt by receptor activator of nuclear factor kappaB ligand (RANKL), the osteoclast differentiation factor, was prominently reduced in the presence of bavachalcone. The induction of c-Fos and NFATc1, key transcription factors for osteoclastogenesis, by RANKL was also suppressed by bavachalcone. Bavachalcone exhibited a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro. Bavachalcone had stronger inhibition on UGT1A1 and UGT1A7 than corylin which did not inhibit UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A10, and UGT2B4. Data fitting using Dixon and Lineweaver-Burk plots demonstrated the noncompetitive inhibition of bavachalcone against UGT1A1 and UGT1A7-mediated 4-MU glucuronidation reaction. The values of inhibition kinetic parameters (Ki) were 5.41 μ M and 4.51μ M for UGT1A1 and UGT1A7, respectively. Synonyms: Broussochalcone B. Grades: >98%. CAS No. 28448-85-3. Molecular formula: C20H20O4. Mole weight: 324.37. | |
| Baxdrostat | Baxdrostat is an aldosterone synthase inhibitor. Synonyms: N-[(8R)-4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide; (R)-N-(4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide; N-[(8R)-4-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl)-5,6,7,8-tetrahydro-8-isoquinolinyl]propanamide; Propanamide, N-[(8R)-5,6,7,8-tetrahydro-4-(1,2,3,4-tetrahydro-1-methyl-2-oxo-6-quinolinyl)-8-isoquinolinyl]-. CAS No. 1428652-17-8. Molecular formula: C22H25N3O2. Mole weight: 363.45. | |
| Bay 02752 | Bay 02752 is a bio-active molecular, but no detailed information has been published yet. Synonyms: Bay-02752; Bay 02752; Bay02752; N,N'-(1,11-Undecanediyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide). Grades: 98%. CAS No. 78991-74-9. Molecular formula: C31H44N4O2. Mole weight: 504.71. | |
| BAY-1142524 | BAY-1142524 is a chymase inhibitor. Chymase is an enzyme that modulates the production of proteins playing a role in adverse cardiac tissue remodeling and fibrogenesis. Study shows that BAY-1142524 could suppress the abnormal cardiac tissue remodeling after myocardial infarction (MI) and improves cardiac function. Uses: Abnormal cardiac tissue remodeling reduction. Synonyms: BAY-1142524; BAY 1142524; BAY1142524. | |
| BAY 19-8004 | BAY 19-8004 is a selective inhibitor of phosphodiesterase-4 (PDE4) used for the treatment of COPD. Uses: The treatment of copd. Synonyms: Lirimilast; SMR004703312; [3-(carbamoylamino)-2-(2,4-dichlorobenzoyl)-1-benzofuran-6-yl] methanesulfonate. Grades: 98%. CAS No. 329306-27-6. Molecular formula: C17H12Cl2N2O6S. Mole weight: 443.26. | |
| BAY-218 | BAY-218, which is known as BAY-2335218, is a potent and selective small-molecule AhR inhibitor with an IC50 of 39.9 nM in human cell line. It is a new modality to counteract tumor immunosuppression. Synonyms: BAY 218; BAY218; BAY-2335218; BAY 2335218; BAY2335218; (S)-6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide; AHR antagonist 1. Grades: ≥98%. CAS No. 2162982-11-6. Molecular formula: C20H17ClFN3O3. Mole weight: 401.82. | |
| BAY-293 | BAY-293 is a potent and cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM. It shows antiproliferative activity against wild-type KRAS cell lines with IC50 of 1 uM and cell lines with KRASG12C mutation with IC50 of 3 uM by preventing formation of the KRAS-SOS1 complex. It is a valuable chemical probe for future investigations. Synonyms: BAY 293; BAY293; (R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine. Grades: ≥98%. CAS No. 2244904-70-7. Molecular formula: C25H28N4O2S. Mole weight: 448.58. | |
| BAY 41-2272 | BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. Synonyms: BAY 41-2272; BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272. Grades: 98%. CAS No. 256376-24-6. Molecular formula: C20H17FN6. Mole weight: 360.39. | |
| BAY-41-8543 | BAY-41-8543, with antihypertensive, is a heme-dependent stimulator of NO-independent guanylyl cyclase (sGC). In vivo, BAY 41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis. In vitro, BAY 41-8543 induces relaxation of aorta, saphenous arteries, coronary arteries and veins. Synonyms: -[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine; BAY-41-8543; BAY418543; BAY41-8543; UNII-323T2C09SG. Grades: 95%. CAS No. 256498-66-5. Molecular formula: C21H21FN8O. Mole weight: 420.44. | |
| BAY 58-2667 hydrochloride | BAY 58-2667, also known as Cinaciguat, is a potent nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). It exhibits antihypertensive effects in vivo and is used in the treatment of acute decompensated heart failure (ADHF). Synonyms: 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate Sulfamate; Cinaciguat HCl; BAY 582667 HCl; BAY-582667 HCl; BAY582667 HCl; BAY 58-2667 HCl; BAY-58-2667 HCl; BAY58-2667 HCl; Cinaciguat HCl. Grades: ≥98% by HPLC. CAS No. 646995-35-9. Molecular formula: C36H39NO5.HCl. Mole weight: 602.16. | |
| BAY-588 | BAY-588 is a glucose transporter inhibitor and derivative of BAY-876. BAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1. It selectively inhibits glucose transporter 4 (Glut4), Glut1, and Glut3 over Glut2 with IC50 values of 0.5, 1.18, 5.47, and >10 μM, respectively, in CHO cells expressing human recombinant transporters. Synonyms: BAY 588; BAY588; N4-[1-[[4-(1,1-Dimethylethyl)phenyl]methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide. Grades: ≥98%. CAS No. 1799759-24-2. Molecular formula: C27H25F4N5O2. Mole weight: 527.5. | |
| BAY-6035 | BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3) with IC50 of 70 nMm, which exhibits >100-fold selectivity for SMYD3 over other histone methyltransferases. BAY-6035 inhibits methylation of MEKK2 peptide in a cell-free assay and in cell. Synonyms: (2S)-1-(3-azabicyclo[3.1.0]hex-3-ylcarbonyl)-N-(2-cyclopropylethyl)-2,3,4,5-tetrahydro-2-methyl-4-oxo-1H-1,5-benzodiazepine-7-carboxamide. Grades: ≥95%. CAS No. 2247890-13-5. Molecular formula: C22H28N4O3. Mole weight: 396.48. | |
| BAY 61-3606 hydrochloride | BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki=7.5 nM; IC50=10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. It shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma. Synonyms: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide monohydrochloride; BAY 61-3606 HCl. Grades: ≥98%. CAS No. 1615197-10-8. Molecular formula: C20H18N6O3·HCl. Mole weight: 426.9. | |
| BAY 677 | BAY 677 is an inactive control for BAY 678 and a human neutrophil elastase (HNE) inhibitor. Synonyms: BAY-677; BAY 677; BAY677; 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 2117404-84-7. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY 678 | BAY 678 is a cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM) that displays around 2000-fold selectivity for NHE over a panel of 21 other serine proteases. Synonyms: BAY 678; BAY678; BAY-678; 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 675103-36-3. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY-721973 | BAY-721973 is a bio-active chemical,but few detailed information has been published yet. Synonyms: BAY-721973; BAY 721973; BAY721973; Sorafenib metabolite M3; UNII-83F1Z938Q0; 4- (4- ( ( ( (4-chloro-3- (trifluoromethyl) phenyl) amino) carbonyl) amino) phenoxy) -N- (hydroxymethyl) -2-Pyridinecarboxamide. Grades: 98%. CAS No. 1380310-94-0. Molecular formula: C21H16ClF3N4O4. Mole weight: 480.83. | |
| BAY 826 | BAY-826 is a selective and potent TIE-2 inhibitor with Kd of 1.6 nM and IC50 of 1.3 nM for autophosphorylation. BAY-826 is highly selective against other angiogenic kinases, such as VEGFR, FGFR, or PDGFR, and affects VEGF-stimulated proliferation of HUVEC. It displays in vivo efficacy in some murine glioma models. Synonyms: [3-Cyano-5- [ [ [2, 4-dimethyl-5- [6- (3-pyridinyl) -1H-imidazo [1, 2-b] pyrazol-1-yl] phenyl] amino] carbonyl] phenyl] pentafluorosulfur. Grades: ≥98% by HPLC. CAS No. 1448316-08-2. Molecular formula: C26H19F5N6OS. Mole weight: 558.53. | |
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