BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| BMS-188494 | BMS-188494 is the prodrug of BMS-187745, a squalene synthase inhibitor used as an anticholesterol drug. Synonyms: 1-[bis (2, 2-dimethylpropanoyloxymethoxy) phosphoryl]-4- (3-phenoxyphenyl) butane-1-sulfonic acid; BMS-188494; BMS 188494; BMS188494; UNII-F4W2579G7P. Grades: >98%. CAS No. 191866-32-7. Molecular formula: C28H39O11PS. Mole weight: 614.645. |  |
| BMS-192364 | BMS-192364 is a prominent and discriminating inhibitor, finding profound application in the research of cancer. Specifically designed for efficacious cancer research, this remarkable compound effectively obstructs kinases that play a crucial role in the propagation and sustenance of malignant cells. Synonyms: 2-(5-chloro-2-hydroxyphenyl)-5-[4-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one; BMS-192364; BMS 192364; BMS192364; UNII-1NC8D8P7QF. Grades: >98%. CAS No. 202822-21-7. Molecular formula: C15H9ClF3N3O2. Mole weight: 355.7. | |
| BMS-195270 | BMS-195270 is a robust and discriminating small molecule inhibitor, finding paramount application in the biomedical sector. Its remarkable efficacy against fibroblast growth factor receptor 4 (FGFR4) imparts exceptional potency, rendering it a formidable intervention modality for malignancies driven by FGFR4. Synonyms: 2-(5-chloro-2-hydroxyphenyl)-5-[2-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one; BMS-195270; BMS 195270; BMS195270; UNII-20UM0T170J; CHEMBL13637; SCHEMBL5754043; 20UM0T170J. Grades: >98%. CAS No. 202822-23-9. Molecular formula: C15H9ClF3N3O2. Mole weight: 355.7. | |
| BMS-210285 | BMS-210285 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: BMS-210285; BMS210285; BMS 210285; UNII-WS7S13Q9RH; CHEMBL60116; WS7S13Q9RH; SCHEMBL13550990; BDBM50073046. N-[5-[(1R)-2-[[(1R)-2-(3-chlorophenyl)-1-[4-(difluoromethoxy)phenyl]ethyl]amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulfonamide. Grades: ≥98%. CAS No. 344607-69-8. Molecular formula: C24H25ClF2N2O5S. Mole weight: 526.98. | |
| BMS-212122 | BMS-212122 is a benzimidazole-based analogue of the potent MTP inhibitor BMS-201038. Synonyms: 9-[4-[2, 5-dimethyl-4-[[2-[4- (trifluoromethyl) phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N- (2, 2, 2-trifluoroethyl) fluorene-9-carboxamide; BMS-212122; BMS212122; BMS 212122; UNII-0Z473OO6GB. Grades: >98%. CAS No. 194213-64-4. Molecular formula: C43H36F6N4O2. Mole weight: 754.76. | |
| BMS 214428 | BMS 214428 has antineoplastic effect. Synonyms: dimethyl 4-[3-[[N-cyano-N'-[3- (4-phenylpiperidin-1-yl) propyl]carbamimidoyl]amino]phenyl]-2, 6-dimethyl-1, 4-dihydropyridine-3, 5-dicarboxylate; UNII-6774Z74TWN; 6774Z74TWN; BMS 214428; BMS-214428; BMS214428. Grades: >98%. CAS No. 216508-01-9. Molecular formula: C33H40N6O4. Mole weight: 584.71. | |
| BMS-214662 mesylate | BMS-214662 mesylate is a potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor cells, including CD34+38- cells, through activation of protein kinase C&beta. Uses: A potent and selective inhibitor of farnesyltransferase. Synonyms: BMS-214662 mesylate; BMS 214662 mesylate; BMS214662 mesylate; (R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine-7-carbonitrile monohydrochloride, (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine mesylate. Grades: ≥98%. CAS No. 474010-58-7. Molecular formula: C25H25N5O6S3. Mole weight: 585.72. | |
| BMS-243117 | BMS-243117 is a potent and selective Lck inhibitor with good cellular activity against T-cell proliferation. BMS-24311 has potential to treat diseases such as rheumatoid arthritis and asthma. Synonyms: BMS-243117; BMS 243117; BMS243117; UNII-MBE6KWV0QI; CHEMBL67237; MBE6KWV0QI; SCHEMBL6058200. 2-(tert-butylcarbamoylamino)-N-(2-chloro-6-methylphenyl)-1,3-benzothiazole-6-carboxamide; BMS-243117; UNII-MBE6KWV0QI. Grades: >98%. CAS No. 225521-80-2. Molecular formula: C20H21ClN4O2S. Mole weight: 416.92. | |
| BMS-247243 | BMS-247243 is a novel β-Lactamase inhibitor which is a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Uses: Beta-lactamase-inhibitor. Synonyms: BMS-247243; BMS 247243; BMS247243; UNII-KG8365V22L. (6R,7R)-7-[[2-[4-[(E)-3-(carboxylatomethylamino)-3-oxoprop-1-enyl]-2,5-dichlorophenyl]sulfanylacetyl]amino]-3-[[2,6-dimethyl-1-[3-(4-methylmorpholin-4-ium-4-yl)propyl]pyridin-1-ium-4-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Grades: ≥98%. CAS No. 307316-55-8. Molecular formula: C36H41Cl2N5O8S3. Mole weight: 838.83. | |
| BMS 262084 | BMS 262084 is a potent and selective azetidinone-based beta-lactam tryptase inhibitor. Synonyms: (2S,3R)-1-[4-(tert-butylcarbamoyl)piperazine-1-carbonyl]-3-[3-(diaminomethylideneamino)propyl]-4-oxoazetidine-2-carboxylic acid; BMS-262084; BMS 262084; BMS262084; CHEMBL71037; UNII-I0IR71971G; I0IR71971G; BDBM50120368; DNC004491. Grades: >98%. CAS No. 253174-92-4. Molecular formula: C18H31N7O5. Mole weight: 425.48. | |
| BMS-279700 | BMS-279700, belonging to a family of novel anilino 5-azaimidazoquinoxaline analogues, is an orally active lead candidate that blocks the production of proinflammatory cytokines (IL-2 and TNFalpha) in vivo. Synonyms: (S)-N-(2-chloro-6-methylphenyl)-2-(3-methylpiperazin-1-yl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine; BMS279700; BMS 279700; BMS-279700. Grades: >98%. CAS No. 240814-54-4. Molecular formula: C21H22ClN7. Mole weight: 407.899. | |
| BMS303141 | BMS 303141 is a cell-permeable, 2-hydroxy-N-arylbenzenesulfonamide that inhibits ACL with an IC50 value of 0.13 μM. BMS 303141 has been reported to reduce weight gain and lower plasma cholesterol, triglycerides, and glucose in a mouse model of hyperlipidemia. Synonyms: BMS303141; BMS-303141; BMS 303141. CAS No. 943962-47-8. Molecular formula: C19H15Cl2NO4S. Mole weight: 424.30. | |
| BMS 309403 | BMS 309403 is a potent, selective and cell-permeable inhibitor of adipocyte fatty acid binding protein (FABP4) with a Ki of less than 2 nM, which exhibits Ki values of 250 nM for FABP3 and 350 nM for FABP5. BMS 309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS 309403 is a biphenyl azole inhibitor against fatty acid binding protein 4 (FABP4) and regarded as a lead compound for effective treatment of obesity related cardio-metabolic diseases. Synonyms: BMS-309403; BMS309403; Adipocyte FABP Inhibitor; A-FABP Inhibitor; ALBP Inhibitor; aP2 Inhibitor; FABP4 Inhibitor; Fatty Acid Binding Protein 4 Inhibitor. Grades: ≥98%. CAS No. 300657-03-8. Molecular formula: C31H26N2O3. Mole weight: 474.55. | |
| BMS-36313 | BMS-363131 is very potent inhibitor of human tryptase with inhibitory activity against bovine trypsin. Uses: Tryptase inhibitor. Synonyms: BMS-363131; BMS 363131; BMS363131. (2S,3R)-3-[[(3R)-1-carbamimidoylpiperidin-3-yl]methyl]-4-oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]azetidine-2-carboxylic acid. Grades: ≥98%. CAS No. 384829-65-6. Molecular formula: C28H40N6O5. Mole weight: 540.66. | |
| BMS-394136 | BMS-394136 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: BMS-394136; BMS 394136; BMS394136;UNII-M694U7167K. [(7R)-7-(3,4-dichlorophenyl)-5-methyl-1,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2S)-2-(4-fluorophenyl)pyrrolidin-1-yl]methanone. Grades: ≥98%. CAS No. 343246-73-1. Molecular formula: C24H21Cl2FN4O. Mole weight: 471.35. | |
| BMS-419437 | BMS-419437 is a synthetic organic bio-active chemical. Uses: A synthetic organic bio-active chemical. Synonyms: BMS-419437; BMS419437; BMS 419437; UNII-09RR39UU4V; CHEBI:34550; AC1NQZWA; BMS-387032 analog 2. N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]-2-[4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenyl]acetamide. Grades: ≥98%. CAS No. 333389-24-5. Molecular formula: C23H30N4O4S2. Mole weight: 490.64. | |
| BMS 433771 | BMS 433771 is a potent inhibitor of RSV replication in vitro with an average EC of 20nM. Uses: Viral fusion protein inhibitor. Synonyms: BMS 433771; BMS433771; BMS-433771; BMS-433771 HCl hydrate; BMS-433771 HCl; BMS-433771 hydrochloride. 1-cyclopropyl-1,3-dihydro-3-((1-(3-hydroxypropyl)-1H-benzimidazol-2-yl)methyl)-2H-Imidazo(4,5-c)pyridin-2-one. Grades: ≥98%. CAS No. 380603-10-1. Molecular formula: C20H21N5O2. Mole weight: 363.41. | |
| BMS-505130 | BMS-505130 is a selective serotonin transport inhibitor with Ki of 0.18 nM. Ki value for binding to the norepinephrine is 4.6 mM and for dopamine transporters is 2.1 mM. Synonyms: BMS-505130; BMS 505130; BMS505130; UNII-E892TW82D9; E892TW82D9;1H-Indole-5-carbonitrile, 3-((1S,2S)-2-((dimethylamino)methyl)cyclopropyl)-, (2Z)-2-butenedioate (1:1). Grades: 98%. CAS No. 859230-84-5. Molecular formula: C19H21N3O4. Mole weight: 355.39. | |
| BMS-505130 Free base | BMS-505130 is a potent and selective serotonin transport inhibitor with K(I) of 0.18 nM. Uses: A potent and selective serotonin transport inhibitor. Synonyms: BMS-505130; BMS 505130; BMS505130; 3-((1S,2S)-2-((dimethylamino)methyl)cyclopropyl)-1H-Indole-5-carbonitrile. Grades: ≥98%. CAS No. 468715-83-5. Molecular formula: C15H17N3. Mole weight: 239.32. | |
| BMS-520 | This active molecular is a selective S1P1 receptor agonist that originated by Bristol-Myers Squibb. BMS-520 shows really good efficacy in animal models of arthritis as well as in a mouse EAE (experimental autoimmune encephalomyelitis) model of multiple sclerosis. Agonism of S1P1 has been known to play an important role in lymphocyte trafficking from the thymus and secondary lymphoid organs, resulting in immunosuppression. Uses: Haematological malignancies; solid tumours. Synonyms: BMS-520; BMS 520; BMS520. 1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid. Grades: 98%. CAS No. 1236188-38-7. Molecular formula: C23H17F3N4O4. Mole weight: 470.41. | |
| BMS-554417 | BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, with the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). Uses: A novel inhibitor of igf-ir. Synonyms: BMS-554417; BMS 554417; BMS554417; 3-[4-[(2Z)-2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxopyridin-3-ylidene]-7-methyl-1,3-dihydrobenzimidazol-5-yl]piperazin-1-yl]propanenitrile. Grades: ≥98%. CAS No. 468741-42-6. Molecular formula: C28H30ClN7O2. Mole weight: 532.04. | |
| BMS561392 | BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA). It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms561392 has the potential treatment of diseases characterized by overproduction of tnf alpha, such as rheumatoid arthritis (ra). Synonyms: BMS-561392; BMS561392; BMS 561392; DPC-333; DPC 333; DPC333. (αR,?3R)?-3-Amino-N-hydroxy-α-(2-methylpropyl)?-3-[4-[(2-methyl-4-quinolinyl)?methoxy]?phenyl]?-2-oxo-1-pyrrolidineacetamide?;BMS-561392;DPC-333;(2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hyd. Grades: 98%. CAS No. 611227-74-8. Molecular formula: C27H32N4O4. Mole weight: 476.57. | |
| BMS587101 | BMS-587101 is an LFA-1 small-molecule antagonist. It could reduce inflammation and joint destruction in murine models of arthritis. It inhibited LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production in vitro. It is developed by Bristol Myers Squibb research. It is used for the treatment of moderate to severe psoriasis. It was in phase II clinical trials, but has been terminated. Uses: Bms-587101 is used for the treatment of moderate to severe psoriasis. Synonyms: BMS-587101; BMS 587101; BMS587101; UNII-5V7E4UQL93. 5-[[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]methyl]thiophene-3-carboxylic acid. Grades: 98%. CAS No. 509083-77-6. Molecular formula: C26H20Cl2N4O4S. Mole weight: 555.43. | |
| BMS 688521 | BMS 688521 is a small molecule antagonist of leukocyte function associated antigen-1 (LFA-1). It has provided proof-of-concept for LFA-1 as an immunological target. BMS 688521 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 2.5 and 78 nM in HUVEC adhesion and mouse specific adhesion assays respectively), which inhibits eosinophil accumulation in the lungs in a mouse allergic eosinophilic lung inflammation model. Synonyms: 6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid; BMS-688521; BMS688521; SCHEMBL5392413. Grades: ≥98%. CAS No. 893397-44-9. Molecular formula: C26H19Cl2N5O4. Mole weight: 536.37. | |
| BMS711939 | BMS711939 is a selective and potent peroxisome proliferator-activated receptor α(PPARα) agonist with EC50 value of 4 nM for human PPAR&alpha. It is >1000-fold selectivity vs human PPARγ with EC50 value of 4.5 μM and PPARδ with EC50 value of > 100 μM in PPAR-GAL4 transactivation assays. It shows excellent in vivo efficacy and safety profiles in preclinical studies. It was chosen for further preclinical evaluation. Uses: Bms711939 was chosen for further preclinical evaluation. Synonyms: BMS-711939; BMS 711939; BMS711939. Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-; 2-[[5-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]-2-fluorophenyl]methyl-methoxycarbonylamino]acetic acid. Grades: >98 %. CAS No. 1000998-62-8. Molecular formula: C22H20ClFN2O6. Mole weight: 462.86. | |
| BMS779333 | BMS779333 is a novel AR pan-antagonist with significantly improved cardiovascular and metabolic profiles. It has anti- tumor effect. Uses: Bms779333 has anti- tumor effect. Synonyms: BMS-779333; BMS779333; BMS 779333; UNII-3MJN2P4998. Benzonitrile, 4-((3aR,4S,6R,6aS,8aS,8bR)-octahydro-4-hydroxy-6-methyl-7-oxo-3a,6-epoxy-3ah-pyrano(2,3,4-cd)isoindol-8(4H)-yl)-2-(trifluoromethyl)-. Grades: >98%. CAS No. 1095181-60-4. Molecular formula: C19H17F3N2O4. Mole weight: 394.35. | |
| BMS-911543 | BMS-911543 is an orally available JAK inhibitor with selectivity for JAK2. It inhibts JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. Synonyms: BMS 911543. Grades: >98%. CAS No. 1271022-90-2. Molecular formula: C23H28N8O. Mole weight: 432.532. | |
| BMS-955829 | BMS-955829 shows excellent Metabotropic glutamate receptor 5 (mGluR5) binding affinity, low glutamate fold shift, and high selectivity for the mGluR5 subtype. BMS-955829 is a potent mGluR5 Positive allosteric modulator (PAM) (EC50 = 2.6 ± 1.0 nM; n=6), devoid of inherent mGluR5 agonist activity (EC50 > 30μM). It may become a new drug candidate for the treatment of schizophrenia. Uses: Schizophrenia. Synonyms: BMS-955829; BMS 955829; BMS955829. (4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one. Grades: 98%. CAS No. 1375751-08-8. Molecular formula: C22H14F2N2O2. Mole weight: 376.36. | |
| BMS-986165 | BMS-986165 is a potent and selective TYK2 inhibitor that blocks signal transduction of IL-23, IL-12, and type I IFNs. It binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. BMS-986165 is under a phase III clinical trial for the treatment of Psoriasis. Synonyms: Tyk2-IN-4; BMS 986165; BMS986165. Grades: 98%. CAS No. 1609392-27-9. Molecular formula: C20H19D3N8O3. Mole weight: 425.47. | |
| BMS-986205 | BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. It is undergoing a phase I/II clinical trial for the bladder and cervical cancer therapy in combination with nivolumab, an anti-programmed cell death protein 1 (PD-1) monoclonal antibody. Uses: Drug combination with nivolumab. Synonyms: BMS-986205; BMS 986205; BMS986205; (2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide. CAS No. 1923833-60-6. Molecular formula: C24H24ClFN2O. Mole weight: 410.917. | |
| BMY 45778 | BMY 45778 is a non-prostanoid prostacyclin mimetic that acts as a partial agonist of IP1 prostacyclin receptors. It inhibits platelet aggregation in vitro (IC50 = 27-35 nM). Synonyms: BMY 45778; BMY45778; BMY-45778. [3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid. Grades: ≥99% by HPLC. CAS No. 152575-66-1. Molecular formula: C26H18N2O5. Mole weight: 438.44. | |
| BO-264 | BO-264 is a highly effective and orally active transforming acidic coiled coil 3 (TACC3) inhibitor with IC50 of 188 nM and Kd of 1.5 nM. It has broad-spectrum anti-tumor activity. Synonyms: BO264; BCP33848; EX-A3407; S8965. Grades: 98%. CAS No. 2408648-20-2. Molecular formula: C18H19N5O3. Mole weight: 353.4. | |
| Boc-β-tert-butyl-L-alanine | Synonyms: Boc-β-tBu-L-Ala-OH; Boc-neopentylglycine; Boc β tBu L Ala OH. Grades: ≥ 99.5% (Chiral HPLC). CAS No. 79777-82-5. Molecular formula: C12H23NO4. Mole weight: 245.32. | |
| Boc-His(Trt)-Aib-OH | Boc-His(Trt)-Aib-OH, a highly specialized peptide synthesis reagent employed within the biomedical industry, presents a powerful capability for the creation of peptide sequences inclusive of unconventional amino acids. Its steadfast utilization helps to promote the generation of distinct and optimal peptide architectures, critical for the progression of targeted drug development, including the likes of Alzheimer's disease, cancer and many other diseases. Synonyms: (S)-2-(2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid. CAS No. 2061897-68-3. Molecular formula: C34H38N4O5. Mole weight: 582.7. | |
| Boc-L-beta-homoalanine | Boc-L-beta-homoalanine, a noteworthy derivative of beta-homoalanine, serves as an essential constituent in the production of peptides and mimics. Its effectivity as a medicinal substance, especially with reference to treating devastating afflictions like Parkinson's, Alzheimer's, and multiple sclerosis, has been the focal point of discussion in relevant studies. Synonyms: (S)-3-((tert-Butoxycarbonyl)amino)butanoic acid; Boc-beta-HoAla-OH; Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, (3S)-. Grades: 95%. CAS No. 158851-30-0. Molecular formula: C9H17NO4. Mole weight: 203.24. | |
| Boc-L-Valinal | Synonyms: N-Boc-2(S)-2-amino-3-methyl-butanal; (S)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate. CAS No. 79069-51-5. Molecular formula: C10H19NO3. Mole weight: 201.26. | |
| Boc-Saxagliptin | An impurity of saxagliptin. Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of type II diabetes. Synonyms: N-[(1S)-2-[(1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hex-2-yl]-1-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-2-oxoethyl]-Carbamic Acid 1,1-Dimethylethyl Ester; Saxagliptin Impurity 16. Grades: > 95%. CAS No. 709031-43-6. Molecular formula: C23H33N3O4. Mole weight: 415.54. | |
| BODIPY Green 8-P2M | BODIPY Green 8-P2M is a thiol-reactive, green-fluorescent dye, and it is relatively selective for reaction with thiol groups when reacted at pH below 7.5. Synonyms: CellHunt Green 8-P2M. CAS No. 929679-22-1. Molecular formula: C23H20BF2N3O2. Mole weight: 419.23. | |
| Bofelisimer | Bofelisimer is an immunomodulator. Synonyms: Nα -{[ (2-ambo-2, 3-dihydroxypropyl) sulfanyl]acetyl}-Nω - (2, 5, 8, 11-tetraoxatridecan-13-yl) poly[N6-{[ (2-ambo-2, 3-dihydroxypropyl) sulfanyl]acetyl}-L-lysine-co-N6-{[ (4-oxo-4-{[2- (4-{[3-O- (3-O-sulfo-β -D-glucopyranuronosyl) -β -D-galactopyranosyl]oxy}phenyl) ethyl]amino}butyl) sulfanyl]acetyl}-L-lysine (~0.65:0.35)]-ω-amide. CAS No. 2485035-32-1. Molecular formula: [ (C11H20N2O4S)x (C32H47N3O18S2)y]n (C14H29NO7S). | |
| BoNT-IN-1 | BoNT-IN-1 is a potent inhibitor of Botulinum neurotoxin A light chain (IC50 = 0.9 uM). Uses: A potent inhibitor of botulinum neurotoxin a light chain. Synonyms: MDK-3033; MDK3033; MDK 3033; BoNT IN 1; BoNT-IN-1; BoNT Inhibitor 1; 2-Methyl-7-{[(4-methyl-2-pyridinyl)amino](2-nitrophenyl)methyl}-8-quinolinol. Grades: ≥95%. CAS No. 694443-03-3. Molecular formula: C23H20N4O3. Mole weight: 400.43. | |
| Borneol 7-O-[β-D-apiofuranosyl-(1?6)]-β-D-glucopyranoside | A monoterpenoid glycoside isolated from the roots of Radix ophiopogonis. A constituent of Shengmai injection. Synonyms: Beta-D-Glucopyranoside, 1,7,7-trimethylbicyclo(2.2.1)hept-2-yl 6-O-D-apio-beta-D-furanosyl-, (1S-endo)-. Grades: >98%. CAS No. 88700-35-0. Molecular formula: C21H36O10. Mole weight: 448.509. | |
| Boscalid | Boscalid is a fungicide belonging to the class of carboxamides. It has been used in agriculture to protect crops. Synonyms: Nicobifen; Endura. CAS No. 188425-85-6. Molecular formula: C18H12Cl2N2O. Mole weight: 343.21. | |
| Bosutinib | Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively. Synonyms: SKI606; SKI 606; SK-I606. Bosutinib; Brand name: Bosulif. Grades: >98%. CAS No. 380843-75-4. Molecular formula: C26H29Cl2N5O3. Mole weight: 530.45. | |
| BPD-Ring B | BPD-Ring B is a product from the synthesis of verteporfinin. It can be used for making porphyrin-related dye, nanoparticles, photosensitizers, and other photodymanic therapeutic drugs. Uses: Make porphyrin-related dye, nanoparticles, photosensitizers, and other photodymanic therapeutic drugs. Synonyms: BPD-B; Benzoporpyrin Ring B derivative;23H,25H-Benzo[b]porphine-9,13- dipropanoic acid, 19-ethenyl-1,22a-dihydro-1,2-bis(methoxycarbonyl)-8,14,18, 22a-tetramethyl-, dimethyl ester. Grades: 98%. CAS No. 143986-17-8. Molecular formula: C42H44N4O8. Mole weight: 732.83. | |
| BPH-652 | BPH-652, also known as BMS-187745, has been found to be a SQS inhibitor that could probably be effective against S. aureus infections. Synonyms: BMS-187745; BPH-652; BMS 187745; BPH 652; BMS187745; BPH652; CHEMBL351151; BMS 188745 Potassium Salt; DNC009027; KB-75764; tripotassium;4-(3-phenoxyphenyl)-1-phosphonatobutane-1-sulfonate. Grades: 98%. CAS No. 157124-84-0. Molecular formula: C16H16K3O7PS. Mole weight: 500.63. | |
| BPH715 | BPH715 is a new generation of lipophilic bisphosphonates. It is potent in cell culture and effectively inhibited tumor cell growth and invasiveness. It is used as anticancer agents that block protein prenylation also have potent activity against Plasmodium liver stages. It has activity against a Plasmodium geranylgeranyl diphosphate synthase (GGPPS), as well as low nM activity against human farnesyl and geranylgeranyl diphosphate synthases. It is used to treat bone resorption diseases and has activity against a broad range of protists, including blood-stage Plasmodium spp. Uses: Bph715 is used as anticancer agents that block protein prenylation also have potent activity against plasmodium liver stages. it is also used to treat bone resorption diseases and has activity against a broad range of protists. Synonyms: BPH-715; BPH 715; BPH715; GTPL3196; GTPL 3196; GTPL-3196; Bisphpshonate-715. 3-(Decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium;Bisphpshonate-715;[2-(3-Decoxypyridin-1-ium-1-yl)-1-phosphonoethyl]-hydroxyphosphinate;Hydrogen (2-(3-(decyloxy)pyridin-1-ium-1-yl)-1-phosphonoethyl)phosphonate. Grades: >98%. CAS No. 1059677-23-4. Molecular formula: C17H31NO7P2. Mole weight: 423.38. | |
| BPIPP | BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. It downregulates cAMP and cGMP synthesis, suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM), inhibits GC-stimulated Cl- transport in vitro, and suppresses toxin-induced intestinal fluid accumulation in vivo. BPIPP may be a useful treatment of diarrhea. Uses: Potential treatment of diarrhea. Synonyms: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione. Grades: ≥99% by HPLC. CAS No. 325746-94-9. Molecular formula: C22H16BrN3O3. Mole weight: 450.28. | |
| BPTES | BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. Grades: 98%. CAS No. 314045-39-1. Molecular formula: C24H24N6O2S3. Mole weight: 524.68. | |
| bpV(HOpic) potassium salt | BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 4.9 μM and PTP-1βB with IC50 of 25.3 μM. It is reported to function as an insulin mimetic and activate the insulin receptor kinase (IRK). BpV(HOpic) has been shown to activate the insulin receptor kinase of hepatoma cells and enhance PI3K/Akt signaling, which could prevent ischemia-reperfusion (I/R) injury to the myocardium. Synonyms: Bisperoxovanadium(HOpic). Grades: ≥95%. CAS No. 722494-26-0. Molecular formula: C6H4NO8V·2K. Mole weight: 347.2. | |
| bpV(phen) potassium hydrate | BpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 38 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 343 nM and PTP-1β with IC50 of 920 nM. At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase. Synonyms: Bisperoxovanadium(phen); Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V). Grades: ≥98%. CAS No. 171202-16-7. Molecular formula: C12H8N2O5V·K+(H2O)3. Mole weight: 404.3. | |
| bpV(pic) potassium hydrate | BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium. It is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 31 nM. It is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells and stimulating lipogenesis in adipocytes. BpV(pic) has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells and is also an inhibitor of G6Pase. Synonyms: Bisperoxovanadium(pic). Grades: ≥96%. CAS No. 148556-27-8. Molecular formula: C6H4NO7V·2K·2H2O. Mole weight: 367.3. | |
| BQR695 | BQR695 is a potent and selective PI4K inhibitor exhibiting potency against both human PI4KIIIβ and Plasmodium falciparum asexual blood stages (IC50?values of 90?nM and 71 nM, respectively). Uses: Antimalarial. Synonyms: NVP-BQR695; NVP-BQR-695; NVP-BQR 695; BQR695; BQR-695; BQR 695. NVP-BQR695; CS-8070; HY-18748; CS 8070; HY 18748; CS8070; HY18748; 2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide. Grades: 99%. CAS No. 1513879-21-4. Molecular formula: C19H20N4O3. Mole weight: 352.39. | |
| BRACO 19 trihydrochloride | BRACO 19 trihydrochloride is a telomerase inhibitor (IC50 = 115 nM) that suppresses the expression of human telomerase reverse transcriptase (hTERT) and induces cellular senescence. BRACO 19 was shown to inhibit growth of uterine cancer cells in vitro and growth of uterine tumor xenografts in mice. Synonyms: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride. Grades: ≥95% by HPLC. CAS No. 1177798-88-7. Molecular formula: C35H43N7O2.3HCl. Mole weight: 703.14. | |
| Brandioside | Brandioside is found in the herbs of Verbena officinalis. Brandioside exhibits inhibitory effect on advanced glycation end product formation and smooth muscle cell proliferation. Synonyms: 2'-O-Acetylpoliumoside; [5-acetyloxy-6-[2-(3,4-dihydroxyphenyl)ethoxy]-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-2-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate. Grades: >98%. CAS No. 133393-81-4. Molecular formula: C37H48O20. Mole weight: 812.771. | |
| Brassinazole | Brassinazole is a potent brassinosteroid (BR) biosynthesis inhibitor that has similar structure to pacrobutrazol. Brassinosteroids are a class of phytohormones with essential roles in plant growth and development, including the promotion of stem elongation and cell division. It has displayed the ability to induce morphological changes in dark-grown Arabidopsis. It can also induce morphological changes, including dwarfism and altered leaf color and curling. Synonyms: Brassinazole. Grades: ≥98%. CAS No. 224047-41-0. Molecular formula: C18H18ClN3O. Mole weight: 327.8. | |
| Brassinin | Brassinin is an inhibitor of indoleamine 2,3-dioxygenase (IDO; Ki = 28 μM for human IDO) with antifungal and anticancer activities. Brassinin also inhibits IL-6-inducible STAT3 activation and attenuates tumor growth in a xenograft lung cancer mouse model. Brassinin is found in brassicas. Synonyms: Brassinine; CCG-208623; CCG208623; CCG 208623; HE-005916; HE005916; HE 005916; HE-292778; HE292778; HE292778; Methyl (1H-indol-3-ylmethyl)carbamodithioate. Grades: 98%. CAS No. 105748-59-2. Molecular formula: C11H12N2S2. Mole weight: 236.36. | |
| BRD32048 | The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300. BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 with KD of 17.1 μM, which reduces p300-dependent acetylation and stability of ETV1. Synonyms: BRD-32048; BRD 32048. Grades: ≥98%. CAS No. 433694-46-3. Molecular formula: C16H22N6O. Mole weight: 314.4. | |
| BRD 4354 | BRD 4354 is an HDAC5 and HDAC9 inhibitor (IC50 = 0.85 and 1.88 μM, respectively) displaying >20-fold selectivity for HDAC5/9 over HDAC1/2/3. It also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Synonyms: BRD4354; BRD 4354; BRD-4354; 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol. Grades: ≥98% by HPLC. CAS No. 315698-07-8. Molecular formula: C21H23ClN4O. Mole weight: 382.89. | |
| BRD 7389 | BRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2, respectively). It upregulates insulin expression in mouse αTC1 pancreatic α cells. Synonyms: BRD7389; BRD-7389; BRD 7389; BAS 05532738; BAS05532738; BAS-05532738; 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione. Grades: ≥97% by HPLC. CAS No. 376382-11-5. Molecular formula: C24H18N2O2. Mole weight: 366.41. | |
| BRD7552 | BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. Synonyms: BRD-7552; BRD 7552; BRD7552. Grades: 95%. CAS No. 1137359-47-7. Molecular formula: C33H33N3O15. Mole weight: 711.63. | |
| Brequinar sodium | Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM), which causes the blockade of de novo pyrimidine nucleotide biosynthesis. Uses: Antineoplastic agents. Synonyms: Dup785; Dup 785; Dup-785; Brequinar Sodium. 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium; Dup 785. Grades: ≥99% by HPLC. CAS No. 96201-88-6. Molecular formula: C23H14F2NO2Na. Mole weight: 397.35. | |
| Brexpiprazole | Brexpiprazole is a novel atypical antipsychotic drug. It is a D2 dopamine partial agonist called serotonin-dopamine activity modulator (SDAM). It is a drug candidate useful in treatment and prevention of mental disorders including CNS disorders. Uses: Brexpiprazole is approved for the treatment of schizophrenia, and as an adjunctive treatment for depression. it is a drug candidate useful in treatment and prevention of mental disorders including cns disorders. Synonyms: 7-[4-(4-(Benzo[b]thien-4-yl)-piperazin-1-yl)butoxy]-1H-quinolin-2-one; OPC 34712. Grades: > 95%. CAS No. 913611-97-9. Molecular formula: C25H27N3O2S. Mole weight: 433.58. | |
| Brexpiprazole Impurity 10 | Brexpiprazole Impurity 10 is an impurity of Brexpiprazole, a drug used to counter psychiatric afflictions such as schizophrenia and major depressive disorder. Synonyms: m-Cinnamanisidide; N-(3-Methoxyphenyl)-3-phenylpropenamide. Grades: > 95%. CAS No. 15116-41-3. Molecular formula: C16H15NO2. Mole weight: 253.30. | |
| Brigatinib | Brigatinib, also known as AP-26113, is an orally active, potent and selective dual ALK/EGFR inhibitor. AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK; IC50 < 100 nM in Ba/F3 cells). AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. It blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants. Synonyms: AP26113. Grades: ≥98%. CAS No. 1197953-54-0. Molecular formula: C29H39ClN7O2P. Mole weight: 584.10. | |
| Brimonidine impurity II | Brimonidine impurity II is an analogue of Brimonidine. Synonyms: N-(4,5-Dihydro-1H-imidazol-2-yl)-6-quinoxalinamine; UK 41511. Grades: > 95%. CAS No. 91147-43-2. Molecular formula: C11H11N5. Mole weight: 213.24. | |
| Brimonidine Related Impurity 2 | Brimonidine Related Impurity 2 is a brimonidine impurity. Synonyms: 4,5-Didehydro Brimonidine; 5-Bromo-N-1H-imidazol-2-yl-6-quinoxalinamine; Brimonidine EP Imprurity F. Grades: > 95%. CAS No. 151110-15-5. Molecular formula: C11H8BrN5. Mole weight: 290.12. | |
| Brinzolamide Related Compound B | Brinzolamide Related Compound B is Brinzolamide derivative. Synonyms: (4R)-4-Amino-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide; AL 8520; N-Desethyl Brinzolamide. Grades: > 95%. CAS No. 404034-55-5. Molecular formula: C10H17N3O5S3. Mole weight: 355.46. | |
| Brinzolamide Related Compound C | Brinzolamide Related Compound C is an isomer of Brinzolamide. Synonyms: (S)-Brinzolamide; (S)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide; AL 4862. Grades: > 95%. CAS No. 154127-19-2. Molecular formula: C12H21N3O5S3. Mole weight: 383.51. | |
| BRITE 338733 | BRITE 338733 is a novel ATPase inhibitor. BRITE 338733 inhibits the expression of RecA in bacteria (IC50 = 4.7 μM) for the treatment of bacterial infections. Uses: A novel atpase inhibitor for the treatment of bacterial infections. Synonyms: BCP0008025; BRITE338733; BCP 0008025; BRITE 338733; BCP-0008025; BRITE-338733; 2-(4-(5-ethylfuran-2-yl)-6-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyridin-2-yl)-4-methylphenol;2-(6-(2,2,6,6-tetramethylpiperidin-4-ylamino)-4-(5-ethylfuran-2-yl)pyridin-2-yl)-4-methylphenol. Grades: ≥98%. CAS No. 503105-88-2. Molecular formula: C27H35O2N3. Mole weight: 433.59. | |
| Bromethalin | Bromethalin is a new rodenticide for the control of commensal rodents. Synonyms: Bromethalin; EL 614; EL-614; EL614. Grades: >98%. CAS No. 63333-35-7. Molecular formula: C14H7Br3F3N3O4. Mole weight: 577.93. | |
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