BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Calcipotriol Impurity H |  | |
| Calcipotriol Impurity I | | |
| Calcipotriol Intermediate 9 | Calcipotriol Intermediate 9 is an intermediate of calcipotriol synthesis. Calcipotriol is a vitamin D3 analogue used for psoriasis treatment. Synonyms: (2E, 4R) -4- [ (1R, 3aS, 4E, 7aR) -4- [ (2E) -2- [ (3S, 5R) -3, 5-Bis [ [ (tert-butyl) dimethylsilyl] oxy] -2-methylenecyclohexylidene] ethylidene] octahydro-7a-methyl-1H-inden-1-yl] -1-cyclopropyl-2-penten-1-one; (5E)-1,3-Bis-O-(tert-Butyldimethylsilyl)-24-oxo-calcipotriene. CAS No. 112849-17-9. Molecular formula: C39H66O3Si2. Mole weight: 639.124. | |
| Calcitonin salmon | Calcitonin salmon, a calcium regulating hormone, has been shown to be an effective alternative for the treatment of postmenopausal osteoporosis. Synonyms: Salmon calcitonin; H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bridge: Cys1-Cys7); L-cysteinyl-L-seryl-L-asparagyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide (1->7)-disulfide; Calciben; Calcimar; Calcitonin (salmon reduced), cyclic (1?7)-disulfide; Calsyn; Calsynar; Catonin; Karil; Miacalcic; Miacalcin; Miadenil; Prontocalcin; Rulicalcin; Salcatonin; Salmon calcitonin; Salmon calcitonin I; Salmon calcitonin-(1-32); Salmon Thyrocalcitonin; Salmotonin; SMC 021 A/C; Stalcin; Tonocalcin. Grades: 98%. CAS No. 47931-85-1. Molecular formula: C145H240N44O48S2. Mole weight: 3431.85. | |
| Calcitonin (salmon) trifluoroacetate salt | Calcitonin is a peptide hormone that lowers blood calcium levels and inhibits bone resorption. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influences affinity of human calcitonin to CTR. Salmon calcitonin binds to human CTR2 with IC50 values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively. Formulations containing salmon calcitonin have been used to treat hypercalcemia, bone destruction by osteoporosis, and Paget's disease. Synonyms: H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2.TFA (Disulfide bond between Cys1 and Cys7); L-cysteinyl-L-seryl-L-asparagyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide (1->7)-disulfide trifluoroacetate salt; Salmon Calcitonin trifluoroacetate (salt). Grades: ≥95%. CAS No. 171052-37-2. Molecular formula: C145H240N44O48S2.xC2HF3O2. Mole weight: 3431.86 (free base). | |
| Calcitriol | Calcitriol is the hormonally active form of vitamin D. Synonyms: RO215535, Topitriol. Grades: >98%. CAS No. 32222-06-3. Molecular formula: C27H44O3. Mole weight: 416.64. | |
| Calcitriol Intermediate | A derivative of vitamin D3 and an intermediate of calcitriol. Calcitriol is a metabolite of vitamin D, and it increases the level of calcium in the blood. Synonyms: (5R)-ethyl-5-((1R,3aS,7aR)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldimethylsilyloxy)-2-methylenecyclohexylidene)ethyl)-7a-Methyloctahydro-1H-inden-1-yl)hexanoate. CAS No. 169900-32-7. Molecular formula: C39H72O4Si2. Mole weight: 661.171. | |
| Calcium 2-oxoglutarate | Calcium 2-oxoglutarate (CAS# 71686-01-6 ) is a useful research chemical. Synonyms: Calcium oxoglurate; calcium 2-oxopentanedioate. CAS No. 71686-01-6. Molecular formula: C5H4CaO5. Mole weight: 184.16. | |
| Calcium glucoheptonate | Calcium glucoheptonate is a calcium supplement. CAS No. 29039-00-7. Molecular formula: C14H26O16Ca. Mole weight: 490.44. | |
| CALP1 trifluoroacetate salt | CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site. CALP1 is also a cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site. CALP1 inhibits Ca2+-mediated cytotoxicity and apoptosis with IC50 of 52 μM and activates phosphodiesterase in the presence of calmodulin and absence of calcium. It also decreases radical production induced by phorbol 12-myristate 13-acetate in broncho-alveolar lavage cells. Synonyms: Calcium-like peptide 1. Grades: ≥95%. Molecular formula: C40H75N9O10·xCF3COOH. Mole weight: 842.08. | |
| CALP3 trifluoroacetate salt | CALP3 is a calcium-like peptide that contains the first eight residues of CALP2, which is a 12-residue peptide that interacts with EF hand motif 4 in human calmodulin to activate it in the absence of calcium. It acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons with IC50 of 37.25 μM. It also inhibits excitatory cytotoxicity with IC50 of 50.97 μM and apoptosis with IC50 of 33.41 μM. CALP3 was used to study as a new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. Synonyms: H-Val-Lys-Phe-Gly-Val-Gly-Phe-Lys-OH.TFA; L-valyl-L-lysyl-L-phenylalanyl-glycyl-L-valyl-glycyl-L-phenylalanyl-L-lysine trifluoroacetate; CALP 3 trifluoroacetate; CALP-3 trifluoroacetate; CALP3 TFA; CALP 3 TFA; CALP-3 TFA; Calcium-like peptide 3 TFA. Grades: ≥98%. Molecular formula: C46H69F3N10O11. Mole weight: 995.11. | |
| Calpain Inhibitor VI | Calpain Inhibitor VI is a cell-permeable peptide aldehyde which functions as a reversible calpain inhibitor. It is an inhibitor of the calcium-dependent cysteine proteases μ-calpain with IC50 of 7.5 nM for calpain-1 and m-calpain with IC50 of 78 nM for calpain-2. Calpain Inhibitor VI can reduce nuclear opacity and proteolysis of crystallins and α-spectrin. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Synonyms: SJA 6017. Grades: ≥95%. CAS No. 190274-53-4. Molecular formula: C17H25FN2O4S. Mole weight: 372.5. | |
| Calpain Inhibitor XII | Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 with Ki of 19 nM. It has been shown to inhibit calpain-2 with Ki of 120 nM and human cathepsin B with Ki of 750 nM. Calpain inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury. Synonyms: Z-L-Nva-CONH-CH2-2-Py. Grades: ≥90%. CAS No. 181769-57-3. Molecular formula: C26H34N4O5. Mole weight: 482.6. | |
| CALYCULIN A | Calyculin A is a effective inhibitor of the catalytic subunit of type-2A phosphatase as well as the type-1 phosphatase. IC50: 0.5 to 1 nM and 2 nM,respectively. It has lower IC50 value than okadaic acid which is a active blocker of phosphatase mentioned a. Uses: Calyculin a is a effective inhibitor of the catalytic subunit of type-2a phosphatase as well as the type-1 phosphatase. Synonyms: CALYCULIN A;CALYCULIN A, DISCODERMIA CALYX;calyculin A from discodermia calyx;CALYCULIN A FROM DISCODERMIA CALYX, 10 U G;N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam;L-Ribonamide. Grades: >98 %. CAS No. 101932-71-2. Molecular formula: C50H81N4O15P. Mole weight: 1009.17. | |
| Camalexin | Camalexin is an indole phytoalexin Camelina sativa and Arabidopsis (Cruciferae), exhibiting antibacterial, antifungal, antiproliferative and anticancer activities. Uses: Anti-infective agents. Synonyms: 3-(1,3-thiazol-2-yl)-1H-indole; 3-(thiazol-2-yl)indole. Grades: 98%. CAS No. 135531-86-1. Molecular formula: C11H8N2S. Mole weight: 200.26. | |
| Camelliaside B | Camelliaside B is a flavonol triglycoside isolated from seeds of Camellia sinensis. Synonyms: Camelliaside B; 131573-90-5; CamelliasideB; 3-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-3-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; CHEMBL501769; CHEBI:183907; LLPRITPJQPQXIR-BVDHFOMSSA-N; HY-N2605; AKOS040756498; MS-31251; CS-0023008; 3-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one. CAS No. 131573-90-5. Molecular formula: C32H38O19. Mole weight: 726.63. | |
| CAM-IN-1 | A potent and selective inhibitor of E-selectin (IC50= 7 nM) and ICAM-1 (IC50= 5 nM). Synonyms: Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl-. CAS No. 251994-14-6. Molecular formula: C15H11BrN2O2S. Mole weight: 363.23. | |
| Camostat Mesylate | Camostat (INN) or FOY-305 is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. It is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease orpancreatitis. Uses: Trypsin inhibitors. Synonyms: 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate methanesulfonate; Camostat Mesilate; Camostat Mesylate; FOY 305; FOY-305; FOY305. Grades: >98%. CAS No. 59721-29-8. Molecular formula: C20H22N4O5.CH4O3S. Mole weight: 494.52. | |
| Campesterol | Campesterol is a phytosterol, primarily found in nuts, fruits, legumes and seeds. It is poorly absorbed in humans and competitively inhibits the absorption of cholesterol. lt decreases the transcription of genes involved in cholesterol metabolism in hepatocytes and enterocytes and has positive impact in treatment of cardiovascular disease. lt was used as standard in GC1 and HPLC2 analysis of oil samples from plants. Synonyms: Campest-5-en-3beta-ol; Ergost-5-en-3beta-ol, (24R)-; Ergost-5-en-3-ol, (3beta,24R)-; 24α-Methyl-5-cholesten-3β-ol. Grades: >98%. CAS No. 474-62-4. Molecular formula: C28H48O. Mole weight: 400.68. | |
| Camrelizumab | Camrelizumab is an anti-PD-1 immune checkpoint inhibitor that is being investigated for hepatocellular carcinoma and Hodgkin lymphoma. Camrelizumab is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1 with immune checkpoint inhibitory and antineoplastic activities. Synonyms: SHR-1210. Grades: ≥98%. | |
| Canfosfamide Hydrochloride | Canfosfamide is a modified glutathione analogue as a small-molecule antineoplastic compound with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. Uses: Glutathione transferase inhibitor. Synonyms: Telcyta; TER 286; TLK 286; TER286; TLK286; TER-286; TLK-286; N5- ( ( (2- ( (bis (bis (2-chloroethyl) amino) phosphoryl) oxy) ethyl) sulfonyl) -D-alanyl) -N5- ( (R) -carboxy (phenyl) methyl) -L-glutamine hydrochloride. Grades: ≥98%. CAS No. 439943-59-6. Molecular formula: C26H41Cl5N5O10PS. Mole weight: 823.93. | |
| Cantharidic acid sodium salt | Cantharidic acid is an inhibitor of protein phosphatases, which is first isolated from Chinese blister beetles. Cantharidic acid is a hydrolysis product of cantharidin, it can inhibits the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 μM, respectively. Cantharidic acid is frequently used to study cellular processes that are regulated by reversible protein phosphorylation. Synonyms: Disodium cantharidin; Cantharidin disodium; 1465-77-6; Disodium cantharidate; 8OIF7X5MK8; Cantharidic Acid (sodium salt); disodium (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate; disodium; (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate; 7-Oxabicyclo(2.2.1)heptane-2,3-dicarboxylic acid, 2,3-dimethyl-, disodium salt, (exo,exo)-; UNII-8OIF7X5MK8. Grades: ≥95%. CAS No. 1465-77-6. Molecular formula: C10H12O5·2Na. Mole weight: 258.2. | |
| Capecitabine impurity D | A Capecitabine analog which shows antitumor activity. Synonyms: 5'-Deoxy-5-fluoro-N4-[(2-methylbutoxy)carbonyl]cytidine; 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine; Capecitabine EP Impurity D; 2-Methylbutyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate; 5'-Deoxy-5-fluoro-N4-(2-methyl-1-butyloxycarbonyl)cytidine. Grades: ≥95%. CAS No. 910129-15-6. Molecular formula: C15H22FN3O6. Mole weight: 359.35. | |
| Capecitabine impurity F | It is an impurity of Capecitabine and is used as an antitumor agent. Synonyms: 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine; [1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]-carbamic Acid 3-Methylbutyl Ester; 5'-Deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine; Isopentyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate; 5'-Deoxy-5-fluoro-N4-(3-methyl-1-butyloxycarbonyl)cytidine; Capecitabine impurity E. Grades: ≥95%. CAS No. 162204-30-0. Molecular formula: C15H22FN3O6. Mole weight: 359.35. | |
| Capromorelin Tartrate | Capromorelin Tartrate is the Tartrate salt of Capromorelin, also known as CP-424,391, which is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a. Synonyms: N-[(2R)-1-[(3aR)-3a-benzyl-2-methyl-3-oxo-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-1-oxo-3-phenylmethoxypropan-2-yl]-2-amino-2-methylpropanamide;(2R,3R)-2,3-dihydroxybutanedioic acid; Capromorelin (Tartrate); Capromorelin tartrate [USAN]; 4150VMF5EP. CAS No. 193273-69-7. Molecular formula: C32H41N5O10. Mole weight: 655.7. | |
| Caprooyl Tetrapeptide-3 acetate | Caprooyl tetrapeptide-3 is a synthetic or plant-derived peptide that stimulates the production of collagen, elastin, and hyaluronic acid. Caprooyl tetrapeptide-3 is used for skin repair. Synonyms: L-Lysyl-N-hexanoylglycyl-L-histidyl-L-lysinamide acetate; N-hexanoyl-L-lysyl-glycyl-L-histidyl-L-lysinamide acetic acid; L-Lysinamide, N2-(1-oxohexyl)-L-lysylglycyl-L-histidyl-, acetate (1:1); KGHK-Caproic Acid; Lys-Gly-His-Lys-Caproic Acid. Grades: ≥95%. CAS No. 1012317-71-3. Molecular formula: C28H51N9O7. Mole weight: 625.76. | |
| Caprospinol | Caprospinol is a β-Amyloid (Aβ) protein neurotoxicity inhibitor that can restore cognitive impairment. It is indicated as an effective therapeutic for Alzheimer's disease (AD). Uses: Therapeutic for alzheimer's disease (ad). Synonyms: Diosgenin caproate; Diosgenin, hexanoate; Caprospinol; SP-233; SP 233; SP233. Grades: 99%. CAS No. 4952-56-1. Molecular formula: C33H52O4. Mole weight: 512.76. | |
| Captopril-cysteine Disulfide | Captopril-cysteine Disulfide is an impurity of Captopril, an orally active angiotensin-converting enzyme (ACE) inhibitor. Synonyms: Captopril-cysteine; 1-[(2S)-3-[[(2R)-2-Amino-2-carboxyethyl]dithio]-2-methyl-1-oxopropyl]-L-proline. CAS No. 75479-46-8. Molecular formula: C12H20N2O5S2. Mole weight: 336.43. | |
| Captopril disulfide | A metabolite of Captopril, an orally active angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and congestive heart failure. Synonyms: 1,1'-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline CAPTOPRDS; SQ 14551; Captopril Imp. A (BP); Captopril EP Impurity A. Grades: > 95%. CAS No. 64806-05-9. Molecular formula: C18H28N2O6S2. Mole weight: 432.56. | |
| Carbamazepine EP Impurity G | Carbamazepine EP Impurity G is an impurity of Carbamazepine, a medication used in the treatment of epilepsy and neuropathic pain. Synonyms: 10-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide; 5-bromobenzo[b][1]benzazepine-11-carboxamide. Grades: >95%. CAS No. 59690-97-0. Molecular formula: C15H11BrN2O. Mole weight: 315.17. | |
| Carbaprostacyclin methyl ester | Carbaprostacyclin is a stable analog of prostacyclin (prostaglandin I2) which can activate the prostacyclin receptor or PPARδ, which ameliorates excess lipid accumulation in diabetic rat placentas. Carbaprostacyclin methyl ester is a more lipid soluble form of carbaprostacyclin. As a result, it may more readily enter cells to activate PPAR&delta. The biological activities of carbaprostacyclin methyl ester have not been studied. Synonyms: Carbaprostacyclin methyl ester; 69552-55-2; methyl (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoate; SCHEMBL16800383; CHEBI:197272; Methyl 5-((3aS,4R,5R,6aS,E)-5-hydroxy-4-((S,E)-3-hydroxyoct-1-en-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoate. Grades: ≥98%. CAS No. 69552-55-2. Molecular formula: C22H36O4. Mole weight: 364.5. | |
| Carbimazole | Carbimazole is used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4. Synonyms: Carbimazole. Grades: >98%. CAS No. 22232-54-8. Molecular formula: C7H10N2O2S. Mole weight: 186.23. | |
| Carbinoxamine | Carbinoxamine is a antihistamine and anticholinergic agent used in the treatment of severe itching in patients with CD5. Uses: Analgesic and anti-inflammatory compound. Synonyms: 2-[(4-Clorophenyl)-2-pyridinylmethoxy]-N,N-dimethylethanamine. Grades: ≥95%. CAS No. 486-16-8. Molecular formula: C16H19ClN2O. Mole weight: 290.79. | |
| Carboxyatractyloside potassium salt | Cas No. 77228-71-8. | |
| Carboxy-PTIO, potassium salt | The potassium salt form of Carboxy-PTIO, which is a water soluble, stable organic free radical that could react stoichiometrically with NO. Synonyms: cPTIO; Carboxy-PTIO; Carboxy PTIO; CarboxyPTIO; 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt. Grades: ≥95% by HPLC. CAS No. 148819-94-7. Molecular formula: C14H16KN2O4. Mole weight: 315.38. | |
| Cardanol monoene | Cardanol monoene is also known as anacardic acid (C15:1). It inhibits the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 with an IC50 of 6.8 mM. Cardanol monoene is also a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 56 μM in vitro. It halts the cell cycle at the S phase and inhibits proliferation dose- and time-dependently in M14 melanoma cells (IC50s = 23.15 and 12.30 μM after 24 and 48 hours of treatment, respectively). A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation. Synonyms: Cardanol C15:1; 6[8'(Z)-pentadecenyl]salicylic acid. Grades: ≥98%. CAS No. 501-26-8. Molecular formula: C21H34O. Mole weight: 302.5. | |
| Carfilzomib | Carfilzomib is a tetrapeptide epoxyketone and an analog of epoxomicin, acting as a selective proteasome inhibitor, such as the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM). It has been used as an injectable antineoplastic agent (IV only). Synonyms: Kyprolis; PR171; PR-171; PR 171; (2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide. Grades: ≥98%. CAS No. 868540-17-4. Molecular formula: C40H57N5O7. Mole weight: 719.9. | |
| Carmustine | Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. It is used in the treatment of brain tumors, multiple myeloma and some lymphomas. Synonyms: 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin. Grades: ≥98%. CAS No. 154-93-8. Molecular formula: C5H9Cl2N3O2. Mole weight: 214.05. | |
| Carotegrast | Carotegrast is an anti-inflammatory agent as a Integrin alpha4 inhibitor. Uses: Integrin alpha4 inhibitors. Synonyms: (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-[6-(dimethylamino)-1-methyl-2,4-dioxoquinazolin-3-yl]phenyl]propanoic acid. Grades: ≥98%. CAS No. 401904-75-4. Molecular formula: C27H24Cl2N4O5. Mole weight: 555.41. | |
| Carperone | Carperone, a butyrophenone derivative, is a bio-active chemical. Synonyms: Carperone; 1-[3- (p-Fluorobenzoyl) propyl]-4-piperidyl=N-isopropylcarbamate; 4'-Fluoro-γ -[4- (isopropylcarbamoyloxy) piperidino]butyrophenone; AL-1021; AL 1021; AL1021. Grades: >98%. CAS No. 20977-50-8. Molecular formula: C19H27FN2O3. Mole weight: 350.43. | |
| Carphenazine Dimaleate | Carphenazine dimaleate is an antipsychotic agent, mainly used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients. Uses: Antipsychotic. Synonyms: (Z)-but-2-enedioic acid;1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]propan-1-one;Wy 2445; Wy2445; Wy-2445. Grades: ≥96%. CAS No. 2975-34-0. Molecular formula: C32H39N3O10S. Mole weight: 657.73. | |
| Carprofen | Carprofen is a COX-2 inhibitor used as a non-steroidal anti-inflammatory drug. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: 6-Chloro-α-methyl-9H-carbazole-2-acetic Acid; (dl)-6-Chloro-α-methylcarbazole- 2-acetic Acid; C 5720; Carprodyl; (+/-)-Carprofen; Imadyl; NSC 297935; Rimadyl; Ro 20-5720. Grades: >98%. CAS No. 53716-49-7. Molecular formula: C15H12ClNO2. Mole weight: 273.71. | |
| Carteolol HCl | Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma. Uses: Anti-arrhythmia agents. Synonyms: Carteolol Hydrochloride ; Carteolol HCl; Arteoptic; Cartrol; Mikelan; Abbott-43326; Hydrochloride, Carteolol; Monohydrochloride, Carteolol; OPC 1085; OPC-1085; OPC1085. Grades: >98%. CAS No. 51781-21-6. Molecular formula: C16H25ClN2O3. Mole weight: 328.83. | |
| Casopitant Mesylate | Casopitant Mesylate is a potent, selective and orally active neurokinin 1 (NK1) receptor antagonist binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. Uses: Active tachykinin nk1 receptor antagonist. Synonyms: (2R,4S)-4-(4-acetylpiperazin-1-yl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide;methanesulfonic acid. Grades: ≥98%. CAS No. 414910-30-8. Molecular formula: C31H39F7N4O5S. Mole weight: 712.72. | |
| Caspofungin | Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. CAS No. 162808-62-0. Molecular formula: C52H88N10O15. Mole weight: 1093.31. | |
| Caspofungin acetate | Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. Synonyms: MK-0991; MK 0991; MK0991; caspofungin diacetate; Cancidas; L 743872; L 743873; 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]pneumocandin B0 Diacetate; 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-(threo-3-hydroxy-L-ornithine)pneumocandin B0 Diacetate. Grades: >98%. CAS No. 179463-17-3. Molecular formula: C56H96N10O19. Mole weight: 1213.42. | |
| Caspofungin Impurity A | Caspofungin Impurity A, is a metabolite of Caspofungin, which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall, and thus used as an antifungal drug. Synonyms: (3S)-(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithyl-L-seryl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-(4-hydroxyphenyl)-L-threonyl-(3R)-3-hydroxy-L-ornithyl-3-hydroxy-L-proline; EX-A3042. Grades: > 95%. CAS No. 1202167-57-4. Molecular formula: C51H86N10O15. Mole weight: 1097.31. | |
| Caspofungin Impurity B | Caspofungin Impurity B is the primary degradation product of Caspofungin, an antifungal agent in echinocandin class. Caspofungi is effective against infections with Aspergillus and Candida and functions via inhibiting β(1,3)-D-Glucan of the fungal cell wall. Molecular formula: C52H88N10O15. Mole weight: 1093.31. | |
| Caspofungin Impurity C | Caspofungin Impurity C is a degradation product of Caspofungin, an antifungal agent in echinocandin class. Caspofungi is effective against infections with Aspergillus and Candida and functions via inhibiting β(1,3)-D-Glucan of the fungal cell wall. Molecular formula: C52H88N10O15. Mole weight: 1093.31. | |
| Caspofungin Impurity D | Caspofungin Impurity D is an impurity of Caspofungin, an antifungal agent in echinocandin class. Caspofungi is effective against infections with Aspergillus and Candida and functions via inhibiting β(1,3)-D-Glucan of the fungal cell wall. Molecular formula: C50H82N8O16. Mole weight: 1051.23. | |
| Caspofungin Impurity E | Caspofungin Impurity E is an impurity of Caspofungin, an antifungal agent in echinocandin class. Caspofungi is effective against infections with Aspergillus and Candida and functions via inhibiting β(1,3)-D-Glucan of the fungal cell wall. Molecular formula: C50H82N8O16. Mole weight: 1051.23. | |
| Caspofungin Impurity F | Caspofungin Impurity Dimer 1 is an impurity of Caspofungin acetate which is an essential component of the cell wall of filamentous fungi. Synonyms: (4R)-N-((2S, 3S, 4S)-1-(((2S)-5-Amino-1-((3S, 4S)-3-carbamoyl-4-hydroxypyrrolidin-1-yl)-3-hydroxy-1-oxopentan-2-yl)amino)-3, 4-dihydroxy-4-(4-hydroxyphenyl)-1-oxobutan-2-yl)-1-((2S)-2-((2R, 4S)-5-((2-(((2R, 6S, 9S, 11R, 12S, 14aS, 15S, 20S, 23S, 25aS)-20-((R)-3-amino-1-hydroxypropyl)-23-((1S, 2S)-1, 2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-9-((10R, 12S)-10, 12-dimethyltetradecanamido)-2, 11, 15-trihydroxy-6-((R)-1-hydroxyethyl)-5, 8, 14, 19, 22, 25-hexaoxotetracosahydro-1H-dipyrrolo[2, 1-c:2', 1'-l][1, 4, 7, 10, 13, 16]hexaazacyclohenicosin-12-yl)amino)ethyl)amino)-2-((10R, 12S)-10, 12-dimethyltetradecanamido)-4-hydroxypentanamido)-3-hydroxybutanoyl)-4-hydroxypyrrolidine-2-carboxamide. Molecular formula: C102H168N18O30. Mole weight: 2126.52. | |
| (-)-Catechin gallate | (-)-Catechin gallate, a minor polyphenolic constituent in green tea, is used to study its cytotoxicity. It enhances Fe(2+)-induced, lipid peroxidation. It also inhibits aromatase activity, an enzyme that converts androgens to estrogen and is thought to play a role in the etiology of breast cancer. Uses: (-)-catechin gallate has been found to be probably effective in restraining tyrosine phosphorylation caused by vegf and have potential activity in the study of breast cancer. Synonyms: (-)-CG; (-)-Catechin gallate; (2S,3R)-2-(3,4-Dihydroxyphenyl)-3-(3,4,5-trihydroxybenzoyloxy)-3,4-dihydro-2H-1-benzopyran-5,7-diol; 3,4,5-Trihydroxybenzoic acid [[(2S)-2β-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran]-3α-yl] ester. Grades: >98%. CAS No. 130405-40-2. Molecular formula: C22H18O10. Mole weight: 442.37. | |
| (±)-Catechin Hydrate | (±)-Catechin is an antioxidant flavonoid. Synonyms: trans-3,3',4',5,7-Pentahydroxyflavane, trans-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol. Grades: 98%. Molecular formula: C15H14O6·xH2O. Mole weight: 290.271 (anhydrous basis). | |
| Catharanthine sulfate | Catharanthine is a natural compound isolated from Catharanthus roseus. It exhibits antitumor activity. Synonyms: Catharanthine sulfate; 70674-90-7; Catharanthine (Sulfate); Catharanthine xSulfate; methyl (1R, 15R, 18R)-17-ethyl-3, 13-diazapentacyclo[13.3.1.02, 10.04, 9.013, 18]nonadeca-2(10), 4, 6, 8, 16-pentaene-1-carboxylate; sulfuric acid; (+)-3,4-Didehydrocoronaridine (Sulfate); CHEMBL2435219; HY-N0252B; EX-A173; CATHARANTHINE; SULFURIC ACID; MFCD06410943; AKOS032946176; AC-34404; PD087203; CS-0009006. Grades: >98%. CAS No. 70674-90-7. Molecular formula: C21H26N2O6S. Mole weight: 434.5. | |
| Cathepsin S inhibitor | Cathepsin S is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases. Synonyms: LY3000328; LY-3000328; LY 3000328. Cathepsin S inhibitor. Grades: >98%. CAS No. 1373215-15-6. Molecular formula: C25H29FN4O5. Mole weight: 484.52. | |
| CATPB | CATPB is a human FFA2 inverse agonist (pKi = 7.87). It increases forskolin-induced cAMP production, and inhibits acetate-induced MAPK signaling in cells expressing human FFA2. Synonyms: (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid. Grades: ≥98% by HPLC. CAS No. 1322598-09-3. Molecular formula: C19H17ClF3NO3. Mole weight: 399.79. | |
| Caulilexin A | Caulilexin A is a phytoalexin found in Brassica oleracea, which exhibits antifungal activity. Synonyms: Caulilexine A; 2-(Methyldithio)-1H-indole-3-carboxaldehyde; 1H-Indole-3-carboxaldehyde, 2-(methyldithio)-. Grades: ≥95%. CAS No. 905914-67-2. Molecular formula: C10H9NOS2. Mole weight: 223.32. | |
| CAY10397 | Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). CAY10397 is a selective inhibitor of 15-hydroxy PGDH, significantly suppressing endogenous 11-oxo-ETE production with a corresponding increase in 11(R)-HETE. It is a selective inhibitor of 15-hydroxy PGDH with IC50 of 10 μM. Synonyms: CK47A. Grades: ≥98%. CAS No. 78028-01-0. Molecular formula: C17H16N2O5. Mole weight: 328.3. | |
| CAY10412 | Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CAY10412 is an analog of AEA that has no intrinsic binding affinity for either CB1 or CB2 receptors. It is a potent inhibitor of AEA reuptake in U937 lymphoma cells with IC50 of 3 μM. It could be a useful tool for distinguishing the competing transporter theories. CAY10412 may enhance endocannabinoid signalling by augmenting endocannabinoid concentrations. Synonyms: CAY 10412; CAY-10412. Grades: ≥98%. CAS No. 390824-17-6. Molecular formula: C25H36O2S. Mole weight: 400.6. | |
| CAY10444 | CAY10444 is a family of related G-protein coupled receptors that bind sphingosine-1 phosphate (S1P) as a high-affinity ligand have recently been cloned. It is a selective antagonist of S1P binding to the S1P3 receptor, blocking the calcium increase in HeLa cells by about 40% when present at 10 μM. Synonyms: BML-241; CAY 10444; CAY-10444; BML 241. Grades: ≥98%. CAS No. 298186-80-8. Molecular formula: C15H29NO2S. Mole weight: 287.5. | |
| CAY10449 | CAY10449 is one of compounds which are found to be high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase. It also inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 3 nM. Synonyms: CAY 10449; CAY-10449. Grades: ≥98%. Molecular formula: C19H21N3O2. Mole weight: 323.4. | |
| CAY10471 | CAY10471 is an analog of BAY-u3405, which contains modifications that increase both its potency and selectivity for the human CRTH2/DP2 receptor. CAY10471 binds to the human DP1 with Ki of 1200 nM and DP2 with Ki of 0.6 nM. It also show very high binding affinity with TP, which Ki can higher than 10,000 nM. Synonyms: CAY-10471; CAY 10471; TM-30089; TM 30089. Grades: ≥95%. CAS No. 627865-18-3. Molecular formula: C21H21FN2O4S. Mole weight: 416.5. | |
| CAY10485 | Acetyl-CoA acetyltransferase, mitochondrial, also known as acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT (Acetyl-Coenzyme A acetyltransferase) gene. Both ACAT-1 and ACAT-2 are acetyl-CoA C-acetyltransferase enzyme. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins. Synonyms: 3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide. Grades: ≥98%. CAS No. 615264-62-5. Molecular formula: C27H27NO7. Mole weight: 477.5. | |
| CAY10486 | Acetyl-CoA acetyltransferase, mitochondrial, also known as acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT (Acetyl-Coenzyme A acetyltransferase) gene. Both ACAT-1 and ACAT-2 are acetyl-CoA C-acetyltransferase enzyme. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of 60 μM. It also inhibits copper-mediated oxidation of low density lipoproteins. Synonyms: 4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide. Grades: ≥98%. CAS No. 615264-52-3. Molecular formula: C19H19NO4. Mole weight: 325.4. | |
| CAY10535 | TPα and TPβ are two isoforms of the human TP receptor, which is the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for TPβ with IC50 of 99 nM than TPα with IC50 of 1970 nM in the inhibition of U46619-mediated Ca2+ mobilization. Synonyms: CAY 10535; CAY-10535. Grades: ≥98%. CAS No. 945716-28-9. Molecular formula: C18H21N3O7S. Mole weight: 423.4. | |
| CAY10566 | Stearoyl-CoA desaturase (SCD) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. CAY10566 is a potent and selective inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. It also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells. Synonyms: CAY 10566; CAY-10566. Grades: ≥98%. CAS No. 944808-88-2. Molecular formula: C18H17ClFN5O2. Mole weight: 389.8. | |
| CAY10577 | Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase that has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm, and other cellular processes. Deregulation of CK2 has been linked to tumorigenesis as a potential protection mechanism for mutated cells. CAY10577 inhibits CK2 with an IC50 value of 0.8 μM. Synonyms: CAY 10577; CAY-10577. Grades: ≥95%. CAS No. 300675-28-9. Molecular formula: C10H5Cl2NO3. Mole weight: 258.1. | |
| CAY10578 | Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase that has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm, and other cellular processes. Deregulation of CK2 has been linked to tumorigenesis as a potential protection mechanism for mutated cells. CAY10578 is a potent inhibitor of CK2 with IC50 value of 0.3 μM. It is ATP competitive and displays Ki value of 0.2 μM. Synonyms: CAY 10578; CAY-10578. Grades: ≥95%. CAS No. 19231-60-8. Molecular formula: C10H3I4NO4. Mole weight: 708.8. | |
| CAY10581 | CAY10581 is a potent IDO inhibitor. Synonyms: CAY10581; CAY 10581; CAY-10581; 1018340-07-2; CHEMBL407954. Grades: > 98%. CAS No. 1018340-07-2. Molecular formula: C22H21NO4. Mole weight: 363.41. | |
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