BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Edonerpic maleate | The maleate salt form of Edonerpic, which is a neuroproptectant. Edonerpic is in clinical trials for the treatment of Alzheimer's disease (AD). It inhibits oxidative stress and nitric oxide-induced neurotoxicity and acts as a neurotrophic factor, as well as it may be beneficial for the treatment of neurodegenerative disorders related to oxidative stress, such as Parkinson's disease. Uses: Candidate therapeutic agent for alzheimer's disease. Synonyms: T-817 maleate; T-817MA; 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol maleate. CAS No. 519187-97-4. Molecular formula: C20H25NO6S. Mole weight: 407.48. |  |
| Edoxaban impurity G | Edaravone Impurity. Synonyms: Edoxaban impurity G; N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4R)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide; ethanediamide, n1-(5-chloro-2-pyridinyl)-n2-[(1s,2r,4r)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-; N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4R)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide; 4-epi-Edoxaban. Grades: > 95%. CAS No. 1255529-26-0. Molecular formula: C24H30ClN7O4S. Mole weight: 548.06. | |
| Edoxaban impurity H | Edoxaban Impurity. Synonyms: N- (5-Chloropyridin-2-yl) -N'- [ (1S, 2S, 4R) -4- [ (dimethylamino) carbonyl] -2- [ [ (5-methyl-4, 5, 6, 7-tetrahydrothiazolo [5, 4-c] pyridin-2-yl) carbonyl] amino] cyclohexyl] ethanediamide. Grades: > 95%. CAS No. 1255529-28-2. Molecular formula: C24H30ClN7O4S. Mole weight: 548.06. | |
| Edoxaban impurity I | The enantiomer of Edoxaban, Edoxaban Impurity. Synonyms: N- (5-Chloropyridin-2-yl) -N'- [ (1R, 2S, 4R) -4- [ (dimethylamino) carbonyl] -2- [ [ (5-methyl-4, 5, 6, 7-tetrahydrothiazolo [5, 4-c] pyridin-2-yl) carbonyl] amino] cyclohexyl] ethanediamide. Grades: > 95%. CAS No. 1255529-23-7. Molecular formula: C24H30ClN7O4S. Mole weight: 548.07. | |
| Edoxaban Tosylate Hydrate | In human plasma, Edoxaban doubles prothrombin time and activates partial thromboplastin time at 0.256 and 0.508 μM, respectively. Synonyms: N- (5-Chloropyridin-2-yl) -N'- ( (1S, 2R, 4S) -4-[ (dimethylamino) carbonyl]-2-[[ (5-methyl-4, 5, 6, 7-tetrahydrothiazolo[5, 4-c]pyridin-2-yl) carbonyl]amino]cyclohexyl) ethanediamide p-Toluenesulfonate hydrate; N- (5-Chloropyridin-2-yl) -N'- [ (1S, 2R, 4S) -4- [ (dimethylamino) carbonyl] -2- [ [ (5-methyl-4, 5, 6, 7-tetrahydrothiazolo [5, 4-c] pyridin-2-yl) carbonyl] amino] cyclohexyl] ethanediamide mono(p-toluenesulfonate) hydrate; Edoxaban p-toluenesulfonate monohydrate. Grades: >98%. CAS No. 1229194-11-9. Molecular formula: C24H30ClN7O4S.C7H8O3S.H2O. Mole weight: 738.27. | |
| Eeyarestatin I | Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Eeyarestatin I suppresses ataxin-3 (atx3)-dependent deubiquitination targeting the p97-associated deubiquinating process (PAD). It also inhibits Sec61-mediated protein translocation at the ER. Eeyarestatin I exhibits cytotoxic activity against cancer cells. Synonyms: 3- (4-Chlorophenyl) -4-[[[ (4-chlorophenyl) amino]carbonyl]hydroxyamino]-5, 5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide. Grades: ≥98% by HPLC. CAS No. 412960-54-4. Molecular formula: C27H25Cl2N7O7. Mole weight: 630.44. | |
| Efaproxiral | synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. One use for efaproxiral is to increase the efficacy of certain chemotherapy drugs which have reduced efficacy against hypoxic tumours, and can thus be made more effective by increased offloading of oxygen into the tumour tissues. However, no benefit was seen for efaproxiral in phase III clinical trials. Synonyms: RSR13; RSR-13; RSR 13; Efaproxyn; NSC722758; (24 (35di methyl anilino) carbonyl methyl phenoxyl2 methyl proprionic acid sodium salt. CAS No. 131179-95-8. Molecular formula: C20H23NO4. Mole weight: 341.4. | |
| Efaproxiral Sodium | Efaproxiral, a synthetic allosteric modi?er of hemoglobinoxygen binding af?nity, has been shown to bind reversibly to hemoglobin, stabilizing the deoxyhemoglobin tetramer conformation to reduce its af?nity for oxygen. Synonyms: Efaproxiral sodium; 170787-99-2; RSR13 SODIUM; Sodium 2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoate; Efaproxiral (sodium); Efaproxiral sodium [USAN]; RSR-13 SODIUM; 3L83QP52XI; 170787-99-2 (sodium); Efaproxyn; Efaproxiral sodium (USAN); Sodium 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoate; Propanoic acid, 2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methyl-, monosodium salt; Efaproxiral Sodium. Grades: >98%. CAS No. 170787-99-2. Molecular formula: C20H23NO4.Na. Mole weight: 363.38. | |
| Efinaconazole | Efinaconazole is a triazole antifungal. It is approved for use in Canada and the USA as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). Efinaconazole acts as a 14α-demethylase inhibitor. Efinaconazole inhibits fungal lanosterol 14α-demethylase involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes. Efinaconazole has been shown to be active against isolates of the following microorganisms, both in vitro and in clinical infections. Efinaconazole exhibits in vitro minimum inhibitory concentrations (MICs) of 0.06 μg/mL or less against most ( ≥ 90%) isolates of the following microorganisms: Trichophyton rubrum; Trichophyton mentagrophytes. Synonyms: KP103; KP-103; KP 103; CTK5J2975; AGJ95634; KB145948; AGJ 95634; KB 145948; AGJ-95634; KB-145948; Efinaconazole; trade name: Jublia. Grades: >98%. CAS No. 164650-44-6. Molecular formula: C18H22F2N4O. Mole weight: 348.39. | |
| Efinaconazole Related Impurity 3 | The S,S-enantiomer of Efinaconazole, a medication used to treat toenail infection caused by fungus. Synonyms: ent-Efinaconazole; (2S,3S)-Efinaconazole; (αS,βS)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidine ethanol; [S-(R*,R*)]-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidine ethanol. Grades: > 95%. CAS No. 164650-45-7. Molecular formula: C18H22F2N4O. Mole weight: 348.39. | |
| Efinaconazole Related Impurity 4 | Efinaconazole impurity. Synonyms: 1-(((2S,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole; 1-[[(2S,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl]methyl]-1,2,4-triazole; 1-{[(2S,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl]methyl}-1H-1,2,4-triazole; QANJLSHZDUOBBP-PELKAZGASA-N; SCHEMBL3949948; (2S,3R)-2-(2,4-difluorophenyl)-3-methyl-2-(1H-1,2,4-triazol-1-yl)methyloxirane. Grades: > 95%. CAS No. 135270-07-4. Molecular formula: C12H11F2N3O. Mole weight: 251.24. | |
| Eflornithine hydrochloride | Eflornithine hydrochloride is a drug found to be effective in the treatment of facial hirsutism. It is a "suicide inhibitor," irreversibly binding to Ornithine Decarboxylase (ODC) and preventing the natural substrate ornithine from accessing the active site. Synonyms: DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; MDL 71782 hydrochloride; RMI 71782 hydrochloride; MDL-71782 hydrochloride; RMI-71782 hydrochloride; α-difluoromethylornithine hydrochloride; Vaniqa hydrochloride. Grades: >98%. CAS No. 68278-23-9. Molecular formula: C6H13ClF2N2O2. Mole weight: 218.63. | |
| Efloxate | Efloxate, a flavone derivative, could be effective in the treatment of chronic coronary insufficiency and angina pectoris for acting as a vasodilator. Uses: Efloxate could be effective in the treatment of chronic coronary insufficiency and angina pectoris for acting as a vasodilator. Synonyms: RE 1-0185; RE-1-0185; RE1-0185; efloxate; EFLOXATE/EFLOXATEM; Corosamin; Domucor; Eflocor; Oxyflavyl; Recordil; 2-(4-keto-2-phenyl-chromen-7-yl)oxyacetic acid ethyl ester. Grades: 98%. CAS No. 119-41-5. Molecular formula: C19H16O5. Mole weight: 324.33. | |
| EG 00229 | EG 00229 is a neuropilin 1 (NRP1) receptor antagonist, inhibiting VEGFA binding to the NRP1 b1 domain. Synonyms: EG00229; EG-00229; EG 00229; N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine. Grades: ≥98% by HPLC. CAS No. 1018927-63-3. Molecular formula: C17H19N7O5S3. Mole weight: 497.57. | |
| EGA | EGA is an inhibitor of endosomal trafficking. EGA is a small molecule that blocks the entry of anthrax lethal toxin by inhibiting trafficking pathways in acidified endosomes, without affecting endosome pH. It also blocks trafficking of other toxins, except ricin. Synonyms: 2-[(4-bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide. Grades: ≥98%. CAS No. 415687-81-9. Molecular formula: C16H16BrN3O. Mole weight: 346.2. | |
| Eggmanone | Eggmanone is a potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM) displaying >40-fold selectivity over PDE3, PDE10, and PDE11. Eggmanone acts via blocking hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Synonyms: 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one. Grades: ≥98% by HPLC. CAS No. 505068-32-6. Molecular formula: C20H20N2O2S3. Mole weight: 416.58. | |
| EHop-016 | EHop-016 is a rac GTPase inhibitor that blocks the interaction of Rac with GEF Vav in metastatic human breast cancer cells. Synonyms: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine; N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine. Grades: 98%. CAS No. 1380432-32-5. Molecular formula: C25H30N6O. Mole weight: 430.5. | |
| EHT 1864 | EHT 1864 is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. Synonyms: EHT 1864; EHT1864; EHT-1864. Grades: >98%. CAS No. 754240-09-0. Molecular formula: C25H29Cl2F3N2O4S. Mole weight: 581.47. | |
| EIDD-1931 | EIDD-1931 is a ribonucleoside analog that exhibits potential antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV. EIDD-1931 induces mutations in RNA virions, inhibiting SARS-CoV-2 and other coronavirus in mice and human airway epithelial cells. Synonyms: N4-Hydroxycytidine; N(4)-Hydroxycytidine; Uridine, 4-oxime; Beta-D-N4-hydroxycytidine. Grades: 99.73%. CAS No. 3258-2-4. Molecular formula: C9H13N3O6. Mole weight: 259.22. | |
| EIDD-2801 | EIDD-2801 derived from a N(4)-hydroxycytidine, is an orally bioavailable broad spectrum antiviral compound that is effective against SARS-CoV2 infection. Uses: Antiviral agents. Synonyms: Molnupiravir; EIDD 2801; EIDD2801; MK-4482; WHO 11853; N4-Hydroxycytidine, 5'-isopropyl ester; beta-D-N4 Hydroxycytidine-5'-isopropyl ester. Grades: 95%. CAS No. 2492423-29-5. Molecular formula: C13H19N3O7. Mole weight: 329.31. | |
| EL-102 | EL102, a HIF1α inhibitor, has been found to have potential effect in restraining polymerisation of tubulin and influencing the stability of microtubule. IC50: 20-40 nM. Uses: El102 is a hif1α inhibitor that has been found to have potential effect in restraining polymerisation of tubulin and influencing the stability of microtubule. Synonyms: EL 102; EL102. Grades: 95%. CAS No. 1233948-61-2. Molecular formula: C19H16N2O3S2. Mole weight: 384.47. | |
| Elagolix sodium | Elagolix is a selective gonadotropin-releasing hormone receptor (GnRHR) antagonist with KD of 54 pM. It is in phase III clinical trials for the treatment of endometriosis and uterine leiomyoma. Elagolix was also under investigation for the treatment of prostate cancer and benign prostatic hyperplasia, but development for these indications was ultimately not pursued. Uses: Endometriosis; uterine leiomyoma. Synonyms: Sodium (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)butanoate;NBI56418 Na; NBI-56418; NBI 56418;834153-87-6 (Elagolix). Grades: 98%. CAS No. 832720-36-2. Molecular formula: C32H29F5N3NaO5. Mole weight: 653.58. | |
| Eldacimibe | Eldacimibe is a Sterol O-acyltransferase inhibitor originated by Wyeth. No development was reported for Atherosclerosis and Hypercholesterolaemia in USA. Uses: Atherosclerosis; hypercholesterolaemia. Synonyms: ACA 147; ANA 147; WAY 125147; WAY ACA 147; 1,3-Dioxane-4,6-dione, 5-(((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)amino)(((4-(2,2-dimethylpropyl)phenyl)-methyl)hexylamino)methylene-2,2-dimethyl. Grades: 98%. CAS No. 141993-70-6. Molecular formula: C39H58N2O5. Mole weight: 634.89. | |
| Elesclomol | Elesclomol is a HSP-90 Inhibitor, and is a small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative stress beyond baseline levels elevates ROS beyond sustainable levels, exhausting tumor cell antioxidant capacity, which may result in the induction of the mitochondrial apoptosis pathway. Normal cells are spared because the increase in the level of oxidative stress induced by this agent is below the threshold at which apoptosis is induced. Elesclomol is currently developed by Synta Pharmaceuticals Corp. Synonyms: STA4783; STA-4783; STA 4783, Elesclomol. CAS No. 488832-69-5. Molecular formula: C19H20N4O2S2. Mole weight: 400.52. | |
| Eleutheroside B1 | Eleutheroside B1 is a coumarin with anti-human influenza virus efficacy. Synonyms: Isofraxidin-7-O-a-D-glucoside. Grades: 98%. CAS No. 16845-16-2. Molecular formula: C17H20O10. Mole weight: 384.33. | |
| Eliglustat | Eliglustat is a glucosylceramide synthase inhibitor indicated for the long-term treatment of type 1 Gaucher disease in patients who are CYP2D6 extensive metabolizers, intermediate metabolizers , or poor metabolizers in treatment-naive and treatment-experi. Uses: Inhibits glucosylceramide synthase(gcs). Synonyms: Genz-99067; Genz 99067; Genz99067;N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide. Grades: ≥98%. CAS No. 491833-29-5. Molecular formula: C23H36N2O4. Mole weight: 404.55. | |
| Eliglustat hemitartrate | Eliglustat hemitartrate is a specific inhibitor of glucosylceramide synthase. It is under development as an oral substrate reduction therapy for Gaucher disease type 1 (GD1). It was developed by Genzyme Corp and has been listed by the FDA August 2014. Synonyms: Genz-112638; Genz 112638; Genz112638; Eliglustat tartrate; Bis(N-((1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(pyrrolidin-1- ylmethyl)ethyl)octanamide) (2R,3R)-2,3-dihydroxybutanedioate; Octanamide, N-((1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1- pyrrolidinylmethyl)ethyl)-, (2R,3R)-2,3-dihydroxybutanedioate; N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide (2R,3R)-2,3-dihydroxybutanedioic acid. Grades: >98%. CAS No. 928659-70-5. Molecular formula: C50H78N4O14. Mole weight: 959.17. | |
| Eliprodil | Eliprodil, a NR2B-NMDA receptor antagonist, was found to have neuroprotective activity in study of ischemia. Uses: Eliprodil is a nr2b-nmda receptor antagonist that was found to have neuroprotective activity in study of ischemia. Synonyms: -(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, SL-82,0715; SL82,0715; SL 82,0715; SL-820715; SL820715; SL 820715; Eliprodil. Grades: 95%. CAS No. 119431-25-3. Molecular formula: C20H23ClFNO. Mole weight: 347.85. | |
| ELN 484228 | ELN 484228 is an α-Synuclein blocker with activity in cellular models of α-synuclein-mediated dysfunction such as Parkinson's Disease. Study showed that ELN484228 reduced synaptic levels of αSyn in neuronal cultures from both wild type rats and from transgenic mice overexpressing αSyn by not more than two-fold. Synonyms: ELN484228; ELN-484228; ELN 484228. N-(4-Fluorophenyl)benzenesulfonamide. Grades: 99%. CAS No. 312-63-0. Molecular formula: C12H10FNO2S. Mole weight: 251.28. | |
| Elobixibat | Elobixibat is a potent and selective IBAT inhibitor under development for the treatment of chronic constipation and irritable bowel syndrome with constipation. Uses: Sodium-bile acid cotransporter-inhibitor. Synonyms: AZD-7806; AZD 7806; AZD7806; A 3309; A3309; A-3309; AJG-533; (2R)-N-[2-[[3,3-Dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,5-benzothiazepin-8-yl]oxy]acetyl]-2-phenylglycylglycine. Grades: ≥95%. CAS No. 439087-18-0. Molecular formula: C36H45N3O7S2. Mole weight: 695.89. | |
| ELQ-300 | ELQ-300 is a potent and orally bioavailable antimalarial agent, and it is a novel inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (complex III in the electron transport chain). Synonyms: 6-chloro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1H-quinolin-4-one. Grades: ≥98%. CAS No. 1354745-52-0. Molecular formula: C24H17ClF3NO4. Mole weight: 475.84. | |
| Elsibucol | Elsibucol, a metabolically stable derivative of probucol, inhibits atherosclerosis and preserves endothelial healing following arterial injury. In vitro, elsibucol reduces vascular smooth muscle cell proliferation without affecting cell viability. Synonyms: 4-[2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenoxy]butanoic acid; (4,2,6-di-tert-butyl-4-(1-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-1-methyl-ethylsulfanyl)-phenoxy-butyric acid); Elsibucol; AGI 1096; AGI1096; AGI-1096; Elsibucol; UNII-O7T92N1Y8T.elsibucol. Grades: >98%. CAS No. 216167-95-2. Molecular formula: C35H54O4S2. Mole weight: 602.94. | |
| Eltanexor | Eltanexor (KPT-8602) is an investigational second-generation SINE compound. Eltanexor acts as an orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20-211?nM in 10 AML lines after 3 days exposure. Synonyms: KPT-8602; ONO-7706; ATG-016. Grades: ≥98%. CAS No. 1642300-52-4. Molecular formula: C17H10F6N6O. Mole weight: 428.29. | |
| Elunonavir | Elunonavir is an antiviral. Synonyms: dimethyl (3S,8S,9S,12S)-6-({4-[1-(difluoromethyl)-1H-pyrazol-3-yl]-2,6-difluorophenyl}methyl)-8-hydroxy-9-{[4-({2-[8-(oxetan-3-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl]pyrimidin-5-yl}ethynyl)phenyl]methyl}-4,11-dioxo-3,12-bis(1,1,1-trifluoro-2-methylpropan-2-yl)-2,5,6,10,13-pentaazatetradecane-1,14-dioate; methyl ((5S,8S,9S,14S)-11-(4-(1-(difluoromethyl)-1H-pyrazol-3-yl)-2,6-difluorobenzyl)-16,16,16-trifluoro-9-hydroxy-15,15-dimethyl-8-(4-((2-(8-(oxetan-3-yl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyrimidin-5-yl)ethynyl)benzyl)-3,6,13-trioxo-5-(1,1,1-trifluoro-2-methylpropan-2-yl)-2-oxa-4,7,11,12-tetraazahexadecan-14-yl)carbamate. CAS No. 2242428-57-3. Molecular formula: C52H59F10N11O8. Mole weight: 1156.09. | |
| EMCS | Cas No. 55750-63-5. | |
| Emeramide | Cas No. 351994-94-0. | |
| Emiglitate | Emiglitate is an α-glucosidase inhibitor that is a powerful inhibitor of glucose-induced insulin release.But no development was reported for the treatment of Diabetes mellitus. Uses: Diabetes mellitus. Synonyms: BAY o 1248; EINECS 279-613-2;Emiglitatum [Latin]; Emiglitate; UNII-PF8AB2IBUM;1,5-Dideoxy-1,5-((2-(4-(ethoxycarbonyl)phenoxy)ethyl)imino)-D-glucitol. Grades: 98%. CAS No. 80879-63-6. Molecular formula: C17H25NO7. Mole weight: 355.38. | |
| Emixustat | Emixustat, a novel visual cycle modulator, is a nonretinoid compound that directly inhibits RPE65, but does not bind to RAR/ RXR retinoid receptors or antagonize retinoid binding proteins. Synonyms: (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol; ACU-4429; emixustat. CAS No. 1141777-14-1. Molecular formula: C16H25NO2. Mole weight: 263.38. | |
| EML-425 | EML-425, a diazinane derivative, has been found to be a CBP/p300 inhibitor that could probably be significant in studies of human leukemia cells. IC50: 1.1 and 2.9 μM, respectively. Synonyms: EML 425; EML-425; EML425; MolPort-042-624-542; BDBM50081125; AKOS027470241; 1,3-dibenzyl-5-[(4-hydroxy-2,6-dimethylphenyl)methylidene]-1,3-diazinane-2,4,6-trione. Grades: 98%. CAS No. 1675821-32-5. Molecular formula: C27H24N2O4. Mole weight: 440.49. | |
| Emlenoflast | MCC7840 is a sulfonylurea non-steroidal anti-inflammatory drug and a potent selective inhibitor of NLRP3 inflammasome with IC50 <100 nM. Synonyms: N-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]-1-(propan-2-yl)-1H-pyrazole-3-sulfonamide; Inzomelid; 1H-Pyrazole-3-sulfonamide, N-(((1,2,3,5,6,7-hexahydro-S-indacen-4-yl)amino)carbonyl)-1-(1-methylethyl)-; N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-1-isopropyl-1H-pyrazole-3-sulfonamide; MCC7840. CAS No. 1995067-59-8. Molecular formula: C19H24N4O3S. Mole weight: 388.48. | |
| Emodin anthrone | Emodin anthrone is a natural product found in Rhamnus prinoides, Paeonia emodi, and Rumex acetosa with data available. Emodinanthrone inhibits respiration-driven solute transport at micromolar concentrations in membrane vesicles of Escherichia coli. Synonyms: Emodinanthrone; emodin-9-anthrone; Emodinol; Protophyscihydrone; 2,4,5-trihydroxy-7-methylanthracen-10(9H)-one. Grades: 95%. CAS No. 491-60-1. Molecular formula: C15H12O4. Mole weight: 256.25. | |
| EMPA | EMPA is a potent and selective OX2 receptor antagonist (IC50 = 2.3 nM and 1900 nM for OX2 and OX1, respectively) with no activity at a panel of 80 receptors. EMPA blocks orexin-B- and orexin-A-invoked calcium mobilization in hOX2-expressing CHO cells (IC50 = 7.9 nM and 8.8 nM, respectively) and reverses orexin-B-induced hyperlocomotion in mice. Synonyms: N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide. Grades: ≥98% by HPLC. CAS No. 680590-49-2. Molecular formula: C23H26N4O4S. Mole weight: 454.54. | |
| Empagliflozin α Isomer | Empagliflozin α Isomer is an isomer of empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: Empagliflozin α-Anomer; (2R,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 1620758-33-9. Molecular formula: C23H27ClO7. Mole weight: 450.91. | |
| Empagliflozin Destetrahydrofuran Impurity | An impurity of empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: O-Desethyl Dapagliflozin; (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. Grades: 98%. CAS No. 864070-37-1. Molecular formula: C19H21ClNO6. Mole weight: 380.83. | |
| Empagliflozin Impurity 17 | An impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: (2R,3S,4R,5R,6S)-2-(Hydroxymethyl)-6-(3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triol; Tetrahydro-2H-pyran-3,4,5-triol, (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl). CAS No. 2452301-27-6. Molecular formula: C23H28O7. Mole weight: 416.46. | |
| Empagliflozin Impurity C | Empagliflozin impurity. Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3R)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol; 3'''-Epi-Empagliflozin. Grades: > 95%. CAS No. 864070-43-9. Molecular formula: C23H27ClO7. Mole weight: 450.91. | |
| Empagliflozin R-Furanose | Empagliflozin R-Furanose is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: Canagliflozine Furanose Impurity; (2R,3R,4R,5R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol; (3R,4R,5R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol. CAS No. 1620758-31-7. Molecular formula: C23H27ClO7. Mole weight: 450.91. | |
| Empagliflozin S-Furanose | Empagliflozin S-Furanose is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. Synonyms: Jardiance Impurity C; (3R,4R,5R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol. CAS No. 1620758-32-8. Molecular formula: C23H27ClO7. Mole weight: 450.91. | |
| EMT inhibitor-1 | EMT inhibitor-1 is a Hippo, TGF-β and Wnt signaling pathway inhibitor with anti-tumor activity. Grades: ≥98% by HPLC. CAS No. 1638526-21-2. Molecular formula: C12H12Cl2N2O2S. Mole weight: 319.2. | |
| Emylcamate | Emylcamateis an anxiolytic and muscle relaxant. It can be used for the treatment of anxiety and tension. Uses: Treatment of anxiety and tension. Synonyms: Emylcamate; Emilcamato; Emylcamat; Nuncital; Psicoplegil; Restetal; Stratran; Striatan; Striatran; Statran; KABI-925; Kabi-295; tert-Hexyl carbamate; MK-250;1-Ethyl-1-methylpropyl carbamate. Grades: 98%. CAS No. 78-28-4. Molecular formula: C7H15NO2. Mole weight: 145.20. | |
| EN460 | EN460 is a small molecule inhibitor by EN460 binding to ERO1α to promote the loss of flavin adenine dinucleotide (FAD) from the holoenzyme(IC50=1.9 uM). Uses: Ero1 inhibitor ii. Synonyms: EN460; EN-460; EN 460. 2-chloro-5-[5-oxo-4-[(5-phenyl-2-furyl)methylene]-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzoic acid. Grades: ≥98%. CAS No. 496807-64-8. Molecular formula: C22H12ClF3N2O4. Mole weight: 460.79. | |
| Enalapril EP Impurity D | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: Enalapril diketopiperazine; Ethyl (2S)-2-[(3S,8aS)-3-methyl-1,4-dioxooctahydropyrrolo [1,2-a]pyrazin-2-yl]-4-phenylbutanoate. Grades: > 95%. CAS No. 115729-52-7. Molecular formula: C20H26N2O4. Mole weight: 358.44. | |
| Enalapril EP Impurity G | An impurity of Enalapril. Enalapril is an angiotensin-converting-enzyme inhibitor used in the treatment of hypertension, diabetic nephropathy, and some types of chronic heart failure. Synonyms: (2S)-2-[[(1S)-3-Cyclohexyl-1-(ethoxycarbonyl)propyl]amino] propanoic acid. Grades: > 95%. CAS No. 460720-14-3. Molecular formula: C15H27NO4. Mole weight: 285.39. | |
| Enbucrilate | Enbucrilate is a surgical tissue adhesive. Enbucrilate is under clinical trials for its intervention in gastric variceal bleeding. Synonyms: Butyl 2-cyanoacrylate; Histoacryl; N-butyl cyanoacrylate; N-Butylcyanoacrylate; butyl 2-cyanoprop-2-enoate. Grades: >98%. CAS No. 6606-65-1. Molecular formula: C8H11NO2. Mole weight: 153.181. | |
| (E)-N-Caffeoylputrescine | (E)-N-Caffeoylputrescine is a fascinating and intricate natural compound unveiling its potent prowess in studying multifarious afflictions. Harnessing its antioxidant might and unfurling an array of anti-inflammatory attributes, this compound is abundantly residing in the botanical realm, aiding in studying cancer, diabetes and neurodegenerative maladies. Synonyms: N-(4-aminobutyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide. Grades: >98%. CAS No. 29554-26-5. Molecular formula: C13H18N2O3. Mole weight: 250.298. | |
| Encorafenib | Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Synonyms: LGX818; LGX-818; LGX 818; Methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate. Grades: ≥98%. CAS No. 1269440-17-6. Molecular formula: C22H27ClFN7O4S. Mole weight: 540.011. | |
| Endochin | Endochin is an experimental antimalarial which was known to be causal prophylactic and potent erythrocytic stage agents in avian models. Uses: Be causal prophylactic and potent erythrocytic stage agents in avian models. Synonyms: 3-heptyl-7-methoxy-2-methylquinolin-4(1H)-one. Grades: ≥98%. CAS No. 354155-51-4. Molecular formula: C18H25NO2. Mole weight: 287.18. | |
| Endomorphin 1 | Endomorphin 1 is a high affinity (Ki = 360 pM) and highly selective agonist of theμ-opioid receptor with 4000- and 15000-fold preference over δ and κ respectively and displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. Uses: Analgesics, opioid. Synonyms: L-tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide. CAS No. 189388-22-5. Molecular formula: C34H38N6O5. Mole weight: 610.7. | |
| Endosidin 2 | Endosidin 2 (ES2) is a cell-permeable benzylidene-benzohydrazide that binds to EXO70 subunit of the exocyst complex which results in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking. Synonyms: ES2; 3-fluoro-benzoic acid, (2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide; (E)-3-Fluoro-N'-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide. Grades: ≥98%. CAS No. 1839524-44-5. Molecular formula: C15H12FIN2O3. Mole weight: 414.2. | |
| Englitazone sodium | Englitazone sodium is a novel blocker of NSCa and KATP channels. It is an antidiabetic agent. Uses: Englitazone sodium is an antidiabetic agent. Synonyms: CP-72467-2;CP72467-2;(-)-5-(((2R)-2-Benzyl-6-chromanyl)methyl)-2,4-thiazolidinedione, sodium salt;Sodium;5-[[(2R)-2-benzyl-3,4-dihydro-2H-chromen-6-yl]methyl]-1,3-thiazolidin-3-ide-2,4-dione;2,4-Thiazolidinedione,5-[[3,4-dihydro-2-(phenylmethyl)-2H-1-benzopyran-6-yl]methyl]-, sodium salt. Grades: >98%. CAS No. 109229-57-4. Molecular formula: C20H18NNaO3S. Mole weight: 375.42. | |
| Eniporide | Eniporide is a potent and selective inhibitor of human Na+/H+ exchanger isoform 1 (NHE-1) (IC50 = 4.5 nM). Synonyms: N-(diaminomethylidene)-2-methyl-5-methylsulfonyl-4-pyrrol-1-ylbenzamide. Grades: ≥95%. CAS No. 176644-21-6. Molecular formula: C14H16N4O3S. Mole weight: 320.4. | |
| Enisamium iodide | Enisamium iodide is an anti-influenza compound. Synonyms: N-benzyl-1-methylpyridin-1-ium-4-carboxamide;iodide; Enisamium iodide; brand name: Amizon. Grades: >98%. CAS No. 201349-37-3. Molecular formula: C14H15N2O.I. Mole weight: 354.19. | |
| Enoxaparin sodium | Cas No. 679809-58-6. | |
| Enprofylline | Enprofylline, a xanthine derivative, is a a competitive nonselective phosphodiesterase inhibitor with relatively little activity as a nonselective adenosine receptor antagonist used in the treatment of asthma, which acts as a bronchodilator. Uses: Nonselective adenosine receptor antagonist. Synonyms: 3-Propylxanthine; 3-propyl-7H-purine-2,6-dione. Grades: ≥98%. CAS No. 41078-02-8. Molecular formula: C8H10N4O2. Mole weight: 194.19. | |
| Ensemble Compound 159 | Ensemble Compound 159 is a peptide inhibitor of IL-17A that binds to IL-17A and/or inhibits formation of the IL-17A-IL-17RA complex via an ELISA assay, an HT29-GROα cell based functional assay, a rheumatoid arthritis synovial fibroblast (RASF) assay, and surface plasmon resonance (SPR, Kd < 100 nM) based biophysical binding assessment. Grades: 97%. CAS No. 1449208-36-9. Molecular formula: C42H51ClN6O6. Mole weight: 771.34. | |
| ENT 25641 | This active molecular is a bio-active chemical and detailed information has not been published yet. Synonyms: 4-(Aminosulfonyl)phenyl dimethyl phosphate,AC 28,865 AI3-25641; American cyanamid CL-28865; Benzenesulfonamide, p-hydroxy-, dimethyl phosphate; BRN 2148113; CL 28865; BRN2148113; CL28865; BRN-2148113; CL-28865. Grades: 98%. CAS No. 115-92-4. Molecular formula: C8H12NO6PS. Mole weight: 281.22. | |
| ENT 25642 | ENT 25642, a sulfamide derivative, could have potential activities in sorts of biological studies. Synonyms: ENT 25642; ENT25642; ENT-25642; BRN 2168785; CL-35217;AC 35,217; ENT 25,642. Grades: 98%. CAS No. 1713-54-8. Molecular formula: C11H18NO5PS2. Mole weight: 339.37. | |
| ent-Cinacalcet Hydrochloride | ent-Cinacalcet Hydrochloride is the (S) enantiomer of Cinacalcet. It is used in clinical trial in secondary hyperparathyroidism. Synonyms: (αS)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine Hydrochloride; (S)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride; (S)-Cinacalcet hydrochloride. Grades: > 95%. CAS No. 694495-47-1. Molecular formula: C22H23ClF3N. Mole weight: 393.87. | |
| ent-Ezetimibe | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L3) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3S,4R)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone. Grades: > 95%. CAS No. 1376614-99-1. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| Entinostat | Entinostat is a histone deacetylase (HDAC) inhibitor displaying antiproliferative and antineoplastic effects. Entinostat induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), which slows cell growth, differentiation, and tumor development in vivo. Entinostat is potentially used as an antitumor drug in combination with other drugs like adriamycin, PARP inhibitors and Hsp90 inhibitors. Uses: Histone deacetylase inhibitors. Synonyms: MS275; MS-275; MS 2275; SNDX275; SNDX-275; SNDX 275; Entinostat; pyridin-3-ylmethyl N-[[4-[ (2-aminophenyl) carbamoyl]phenyl]methyl]carbamate. Grades: > 98%. CAS No. 209783-80-2. Molecular formula: C21H20N4O3. Mole weight: 376.416. | |
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