MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| I-152 | I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 311343-11-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153340. |  |
| I-191 | I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1690172-25-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117793. | |
| I-287 | I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on G?q and G?12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2014368-93-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148016. | |
| I3MT-3 | I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 ?M). I3MT-3 is inactive for other H2S/sulfane sulfur-producing enzymes.?I3MT-3 targets a persulfurated cysteine residue located in the active site of 3MST[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HMPSNE. CAS No. 459420-09-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128206. | |
| I942 | I942 is a first in class, selective non-cyclic nucleotide (NCN) EPAC1 agonist. I942 can attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 868145-09-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-129738. | |
| IA-Alkyne | IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection[1]. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling[2]. IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide. CAS No. 930800-38-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-136205. | |
| IACS-010759 | IACS-010759 is an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 has the potential for relapsed/refractory AML and solid tumors research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IACS-10759. CAS No. 1570496-34-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112037. | |
| IACS-010759 hydrochloride | IACS-010759 hydrochlorideis an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 hydrochlorideinhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 hydrochloride has the potential for relapsed/refractory AML and solid tumors research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IACS-10759 hydrochloride. CAS No. 1807523-99-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112037A. | |
| IACS-9571 hydrochloride | IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1 , with an IC 50 of 8 nM for TRIM24, and K d s of 31 nM and 14 nM for TRIM24 and BRPF1, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASIS-P040 hydrochloride. CAS No. 2319611-93-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-102000B. | |
| Iadademstat | Iadademstat (ORY-1001) is a highly potent, orally active and selective LSD1 (KDM1A) inhibitor with antileukemic activity. Iadademstat can be used for relapsed or refractory acute myeloid leukemia research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ORY-1001. CAS No. 1431304-21-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-109117. | |
| Iadademstat dihydrochloride | Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A ( KDM1A / LSD1 ) inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride. CAS No. 1431303-72-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12782T. | |
| IAG933 | IAG933 (YAP-TEAD-IN-3) is an orally available YAP/TAZ-TEAD inhibitor that has anti-tumor effects and promotes apoptosis. IAG933 YAP-TEAD-IN-3 inhibits Avi-human TEAD 4217-434 , with an IC 50 value of 9 nM [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YAP-TEAD-IN-3. CAS No. 2714434-21-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-153811. | |
| IALYLQQNW | IALYLQQNW is a specific nonapeptide sequence derived from the tumor-associated antigen latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV). As a latent T-cell epitope, IALYLQQNW is able to activate EBV-specific cytotoxic T lymphocytes (CTLs), which are able to recognize and kill EBV-infected cells expressing LMP1. IALYLQQNW plays an important role in the immune response against EBV-associated tumors and can be used in the study of Hodgkin's disease and nasopharyngeal carcinoma [1]. Uses: Scientific research. Group: Peptides. CAS No. 610268-80-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10607. | |
| Ianalumab | Ianalumab (VAY-736) is a human, decarboxylated antibody against BAFF-R. Ianalumab can block the interaction between BAFF and BAFF-R and antagonize the apoptosis protection mediated by BAFF. Ianalumab exerts antibody-dependent cytotoxic (ADCC), depending on effector cell activation mediated by immune receptor tyrosine activation motif (ITAM) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: VAY-736. CAS No. 1929549-92-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99653. | |
| IAXO-102 | IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-?B phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1115270-63-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125171. | |
| Ibacitabine | Ibacitabine, an antiviral compound, can be used for gene sequencing [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 5-Iodo-2'-deoxycytidine. CAS No. 611-53-0. Pack Sizes: 5 g; 10 g. Product ID: HY-W011138. | |
| Ibalizumab | Ibalizumab (TMB-355) is a humanised IgG4 monoclonal antibody that prevents HIV cell entry by binding to CD4 receptor. Ibalizumab has the potential for HIV-1 infection research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TMB-355; TNX-355. CAS No. 680188-33-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99028. | |
| Ibandronate Sodium Monohydrate | Ibandronate Sodium Monohydrate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BM-210955; RPR-102289A. CAS No. 138926-19-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0515. | |
| Iberdomide | Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC 50 of ~150?nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CC-220. CAS No. 1323403-33-3. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101291. | |
| Iberiotoxin | Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca 2+ -activated K + channel inhibitor with a K d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 129203-60-7. Pack Sizes: 100 μg. Product ID: HY-P0190. | |
| I-BET151 | I-BET151 (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4 , BRD2 , and BRD3 with pIC 50 of 6.1, 6.3, and 6.6, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK1210151A. CAS No. 1300031-49-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13235. | |
| Ibetazol | Ibetazol is an inhibitor for importin ?1 (KPNB1), that inhibits that binds to Cys585 of importin ?1, inhibits the importin ?1 mediated nuclear import with an EC50 of 6.1 μM[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170316. | |
| Ibezapolstat | Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a K i of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat is developed for the research of C. difficile infection(CDI) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACX-362E; GLS-362E. CAS No. 1275582-97-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128357. | |
| Ibiglustat | Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Venglustat; SAR402671; GZ402671. CAS No. 1401090-53-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16743. | |
| Ibiglustat succinate | Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Venglustat succinate; SAR402671 succinate; GZ402671 succinate. CAS No. 1629063-80-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16743B. | |
| (±)-Ibipinabant | (±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 ( CB-1 ) receptor antagonist with an IC 50 of 22 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-SLV319; (±)-BMS-646256. CAS No. 362519-49-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14791A. | |
| IBMX | IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 ?M for PDE3, PDE4 and PDE5, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine. CAS No. 28822-58-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-12318. | |
| Ibotenic acid | Ibotenic acid has agonist activity at both the N-methyl-D-aspartate ( NMDA ) and trans-ACPD or metabolotropic quisqualate (Q m ) receptor sites. Uses: Scientific research. Group: Natural products. Alternative Names: (RS)-Ibotenic acid; DL-Ibotenic acid. CAS No. 2552-55-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2311. | |
| iBRD4-BD1 | iBRD4-BD1 is selective BRD4 bromodomain inhibitor. iBRD4-BD1 has inhibition activity for BRD4 bromodomain with an IC 50 value of 12 nM. iBRD4-BD1 can be used for the research of inflammation and oncology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2839318-17-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151594. | |
| I-BRD9 | I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 ?M. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1714146-59-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18975. | |
| Ibrexafungerp | Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp can be used for research of Candida and Aspergillus infections [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK 3118; SCY-078. CAS No. 1207753-03-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-107126. | |
| Ibrexafungerp citrate | Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK 3118 citrate; SCY-078 citrate. CAS No. 1965291-08-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107126A. | |
| Ibrolipim | Ibrolipim (NO-1886) is an orally active lipoprotein lipase (LPL) -promoting agent. Ibrolipim decreases plasma triglycerides, increases high-density lipoprotein cholesterol levels. Ibrolipim has renoprotective and hypolipidemic effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NO-1886. CAS No. 133208-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117549. | |
| Ibrutinib | Ibrutinib (PCI-32765) is a selective, irreversible Btk inhibitor with an IC 50 of 0.5 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCI-32765. CAS No. 936563-96-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10997. | |
| Ibrutinib deacryloylpiperidine | Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib [1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC 50 of 0.5 nM [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IBT4A. CAS No. 330786-24-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-78727. | |
| Ibrutinib Racemate | Ibrutinib Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC 50 value of 0.5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PCI-32765 Racemate. CAS No. 936563-87-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10997A. | |
| Ibudilast | Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase ( PDE ) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KC-404; AV-411; MN-166. CAS No. 50847-11-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0763. | |
| Ibufenac | Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dytransin. CAS No. 1553-60-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W040672. | |
| Ibuprofen | Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC 50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers [1] [2] [5] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Ibuprofen. CAS No. 15687-27-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-78131. | |
| Ibuprofen-d3 | Ibuprofen-d3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 ?M and 370 ?M[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: (±)-Ibuprofen-d3. CAS No. 121662-14-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-78131S. | |
| Ibuprofen L-lysine | Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC 50 value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Ibuprofen L-lysine. CAS No. 57469-77-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100586. | |
| Ibuprofen sodium | Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC 50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers [1] [2] [5] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Ibuprofen sodium. CAS No. 31121-93-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-78131C. | |
| Ibutamoren Mesylate | Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-677; MK-0677. CAS No. 159752-10-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-50844. | |
| Ibutilide | Ibutilide (U70226E free base), an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K + current ( I Kr ) in AT-1 cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: U70226E free base. CAS No. 122647-31-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0387A. | |
| Ibutilide fumarate | Ibutilide (U70226E) fumarate, an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K + current ( I Kr ) in AT-1 cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: U70226E. CAS No. 122647-32-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0387. | |
| Ibuzatrelvir | Ibuzatrelvir (PF-07817883), a second-generation, orally bioavailable, is SARS-CoV-2 main protease ( M pro and 3CL pro ) inhibitor with improved metabolic stability. Ibuzatrelvir has demonstrated pan-human coronavirus antiviral activity and off-target selectivity profile in vitro and in preclinical animal studies. Ibuzatrelvir is well tolerated with a safety profile similar to placebo and prevents viral infection and transmission. Ibuzatrelvir can be used to inhibit COVID-19 [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-07817883. CAS No. 2755812-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156654. | |
| ICA | ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC 50 of 2.1 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine. CAS No. 3374-88-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-22044. | |
| ICA-105574 | ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 ?M and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 can prevent arrhythmias induced by cardiac delayed repolarization. ICA-105574 shortens action potential duration in ventricular myocytes concentration-dependently[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 316146-57-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124702. | |
| ICA-27243 | ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 ?M. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 325457-89-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122114. | |
| ICAM-1-IN-1 | ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC 50 values of 7 and 5 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 251994-14-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00003. | |
| Icanbelimod | Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S1p receptor agonist 1. CAS No. 1514888-56-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101265. | |
| Icariin | Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC 50 s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Uses: Scientific research. Group: Natural products. Alternative Names: Ieariline. CAS No. 489-32-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-N0014. | |
| Icaritin | Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornu Maxim. and potently inhibits proliferation of K562 cells ( IC 50 of 8 μM) and primary CML cells ( IC 50 of 13.4 μM for CML-CP and 18 μM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis [1] [2] [3. Uses: Scientific research. Group: Natural products. Alternative Names: Anhydroicaritin. CAS No. 118525-40-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0678. | |
| Icatibant | Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC 50 and K i of 1.07 nM and 0.798 nM respectively [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: HOE 140. CAS No. 130308-48-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-17446. | |
| Icatibant acetate | Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC 50 and K i of 1.07 nM and 0.798 nM respectively [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: HOE 140 acetate. CAS No. 138614-30-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108896. | |
| ICCB-19 hydrochloride | ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1803605-68-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138779. | |
| Icenticaftor | Icenticaftor (QBW251) is an orally active CFTR channel potentiator, with EC 50 s of 79 nM and 497 nM for F508del and G551D CFTR , respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: QBW251. CAS No. 1334546-77-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109177. | |
| Icerguastat | Icerguastat (Sephin1), a derivative of Guanabenz lacking the ?2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2? dephosphorylation, thereby prolonging the protective response. Anti-prion effect[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sephin1; IFB-088. CAS No. 951441-04-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111022. | |
| ICG-001 | ICG-001 is an inhibitor of β-catenin/TCF mediated transcription. ICG-001 works by specifically binding to cyclic AMP response element-binding protein with an IC 50 of 3 μM. ICG-001 selectively blocks the β-catenin/CBP interaction without interfering with the β-catenin/p300 interaction. Uses: Scientific research. Group: Signaling pathways. CAS No. 780757-88-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14428. | |
| ICG-DBCO | ICG-DBCO is a near-infrared fluorescent dye that is widely used in cell dyes, biological dyes, biomolecules and particle fluorescent labeling.Ex/Em = 789/813 nm. Uses: Scientific research. Group: Fluorescent dye. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W588722. | |
| ICG Maleimide | ICG Maleimide is thiol reactive near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging (Ex/Em = 789/813 nm). Uses: Scientific research. Group: Fluorescent dye. CAS No. 2143933-81-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-D1744. | |
| ICG-OSu | ICG-OSu (ICG NHS ester) is a near-infrared fluorescent agent ICG derivative. ICG-OSu is amine-reactive and has been widely used to design in vivo imaging probes[1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: ICG NHS ester. CAS No. 1622335-40-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-D1041. | |
| ICI 174864 | ICI 174864 is a highly selective, potent δ-receptor antagonist. ICI 174864 is equipotent with naloxone and can not reverse the effect of the μ-agonist [D-Ala2, MePhe4, Gly-Ol5]enkephalin or the κ-agonist-tifluadom [1]. Uses: Scientific research. Group: Peptides. CAS No. 89352-67-0. Pack Sizes: 1 mg. Product ID: HY-101230. | |
| ICI 199441 | ICI 199441 is a potent and selective κ-opioid receptor agonist. ICI 199441 can improve heart resistance to ischemia/reperfusion [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 115199-84-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101205. | |
| ICI-204448 | ICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 121264-04-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-101231. | |
| ICI 216140 | ICI 216140 is a GRP/bombesin receptor 2 antagonist with the IC 50 of 2 nM. ICI 216140 can reduce Bombesin (HY-P0195)-stimulated pancreatic amylase secretion and attenuates Bombesin (HY-P0195)-stimulated increases in blood pressure [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 124001-41-8. Pack Sizes: 1 mg. Product ID: HY-P3112. | |
| ICI-63197 | ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with K i values of 9 μM and 10 μM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 27277-00-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103024. | |
| Icilin | Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 ( TRPM8 ) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner ( EC 50 =1.4 μM). Icilin is a "super-cooling agent" [1] [2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-3-5. CAS No. 36945-98-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-11062. | |
| Iclaprim | Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus ( MRSA ) with an MIC 90 of 0.06 μg/mL. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AR-100. CAS No. 192314-93-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101479. | |
| Iclepertin | Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI-425809. CAS No. 1421936-85-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138935. | |
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