MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Icomidocholic acid | Icomidocholic acid (Aramchol) is a lipid molecule synthesized from cholic acid and arachidic acid. Icomidocholic acid is an orally active SCD1 inhibitor and cholesterol solubilizer with antifibrotic effects. Icomidocholic acid can reduce liver fat content, dissolve cholesterol crystals and prevent gallstone formation. Icomidocholic acid can be used in the study of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Aramchol; C20-FABAC. CAS No. 246529-22-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19796. |  |
| Icosabutate | Icosabutate, an orally active ω-3 polyunsaturated fatty acid, is an aeicosapentaenoic acid (EPA) derivative. Icosabutate overcomes the drawbacks of unmodified EPA for liver targeting and improves insulin sensitivity, hepatic inflammation and fibrosis [1]. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persistent hypertriglyceridemia [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253909-57-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121212. | |
| Icotinib | Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with an IC 50 of 5 nM; also inhibits mutant EGFR L858R , EGFR L858R/T790M , EGFR T790M and EGFR L861Q. Icotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BPI-2009. CAS No. 610798-31-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15164A. | |
| Icotinib Hydrochloride | Icotinib Hydrochloride (BPI-2009) is a potent and specific EGFR inhibitor with an IC 50 of 5 nM; also inhibits mutant EGFR L858R , EGFR L858R/T790M , EGFR T790M and EGFR L861Q. Icotinib (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BPI-2009H. CAS No. 1204313-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15164. | |
| Icotrokinra | Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC50=5.6 pM) and inhibits IL-23-induced interferon IFN-? production in NK cells with an IC50 of 18.4 pM. In addition, Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease[1]. Uses: Scientific research. Group: Peptides. Alternative Names: JNJ-77242113; JNJ-2113; PN-235. CAS No. 2763602-16-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10587. | |
| ICRF-193 | ICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 21416-88-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118590. | |
| iCRT 14 | iCRT 14 is a novel potent inhibitor of ?-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase. Uses: Scientific research. Group: Signaling pathways. CAS No. 677331-12-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16665. | |
| iCRT3 | iCRT3 is an inhibitor of both Wnt and ?-catenin-responsive transcription. Uses: Scientific research. Group: Signaling pathways. CAS No. 901751-47-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103705. | |
| Icrucumab | Icrucumab (Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1) is a human Anti-VEGFR-1 IgG1 monoclonal antibody. Icrucumab has the potential for the research of advanced solid tumors[1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1. CAS No. 1024603-92-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99364. | |
| ID-8 | ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 147591-46-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15838. | |
| Idalopirdine hydrochloride | Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a K i value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Lu AE58054 hydrochloride. CAS No. 467458-02-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14338A. | |
| Idarubicin hydrochloride | Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Demethoxydaunorubicin hydrochloride. CAS No. 57852-57-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17381. | |
| Idasanutlin | Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC 50 of 6 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG7388. CAS No. 1229705-06-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15676. | |
| Idazoxan hydrochloride | Idazoxan hydrochloride (RX 781094 hydrochloride) is an α 2 -adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinsons disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RX 781094 hydrochloride. CAS No. 79944-56-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-14561A. | |
| IDE1 | IDE1 is an inducer of definitive endoderm 1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1160927-48-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100533. | |
| IDE 2 | IDE2 is a small molecule cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) by activating the TGF-βsignaling pathway [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1136466-93-7. Pack Sizes: 1 mg. Product ID: HY-100534. | |
| Idebenone | Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC 50 =16.65 μM) [1]. Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells [2]. Idebenone quickly crosses the blood-brain barrier. Uses: Scientific research. Group: Signaling pathways. CAS No. 58186-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0303. | |
| Idelalisib | Idelalisib (CAL-101; GS-1101) is a highly selective and orally bioavailable p110δ inhibitor with an IC 50 of 2.5 nM, showing 40- to 300-fold selectivity for p110δ over other PI3K class I enzymes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CAL-101; GS-1101. CAS No. 870281-82-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13026. | |
| IDF-11774 | IDF-11774 is a novel hypoxia-inducible factor ? (HIF?)-1 inhibitor with an IC50 of 3.65??M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1429054-28-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-111387. | |
| IDO1-IN-19 | IDO1-IN-19 (Compound 17) is an orally active IDO1 inhibitor with an IC 50 of CYP2C9 of 8.64 μM. IDO1-IN-19 also acts funciton on cardiac channels, with IC 50 s of 12 μM ( IKr ), 40 μM ( INa ), 8.3 μM ( ICa ), respectively. IDO1-IN-19 has the potential to study cancer diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2328099-11-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144652. | |
| IDO-IN-12 | IDO-IN-12 is an indoleamine 2,3-dioxygenase ( IDO ) inhibitor extracted from patent WO 2017181849 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1888341-29-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115122. | |
| IDOR-4 | IDOR-4 is a type IV CFTR corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2839901-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-158002. | |
| Idoxifene | Idoxifene (CB7432) is a novel tissue-specific selective estrogen receptor modulator ( SERM ). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CB7432. CAS No. 116057-75-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00178. | |
| Idoxuridine | Idoxuridine (5-Iodo-2-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC 50 value of 4.3 μM [1]. Idoxuridine shows anti-orthopoxvirus activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5-Iodo-2-deoxyuridine; 5-IUdR; IdUrd. CAS No. 54-42-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0307. | |
| IDR-1 | IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 940291-10-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2320. | |
| IDR 1002 | IDR-1002 is an anti-infective peptide that enhances the ability of human monocytes to migrate toward chemokines on fibronectin. IDR-1002 also induces adhesion and activation of β1-integrin, a mechanism that promotes monocyte recruitment [1]. Uses: Scientific research. Group: Peptides. CAS No. 1224095-25-3. Pack Sizes: 1 mg. Product ID: HY-P5812. | |
| IDRA 21 | IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 22503-72-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-101528. | |
| IDT307 | IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+)[1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1141-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129096. | |
| IDX184 | IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase ( IC 50 =0.31 μM, K i =52.3 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1036915-08-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-19558. | |
| IEM-1460 | IEM-1460 blocks both AMPA and NMDA glutamate receptor with anticonvulsant effect in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 121034-89-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103230. | |
| Ieramilimab | Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3 , resulting in inhibition of LAG-3 interaction with MHC-II molecules [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LAG525; IMP701. CAS No. 2137049-37-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99027. | |
| Ifebemtinib | Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase ( FAK ) inhibitor (recombinant FAK IC 50 =1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC 50 s of 900 nM and 1040 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI-853520; IN-10018. CAS No. 1227948-82-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122844. | |
| Ifenprodil tartrate | Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors ( IC 50 =0.34 μM) over 400-fold than at NR1A/NR2A receptors ( IC 50 =146 μM) [1]. Ifenprodil tartrate inhibits GIRK (Kir3) , reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator [2]. Uses: Scientific research. Group: Natural products. CAS No. 23210-58-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-12882A. | |
| Iferanserin | Iferanserin (S-MPEC) is a selective 5-HT receptor ( serotonin receptor ) antagonist with an affinity for 5-HT 2A receptor. Iferanserin has the potential for internal hemorrhoid disease treatment [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S-MPEC. CAS No. 58754-46-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118557. | |
| Ifetroban | Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291. CAS No. 143443-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218. | |
| Ifetroban sodium | Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 ( TXA2 ) or prostaglandin H2 ( PGH2 ) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-180291 sodium. CAS No. 156715-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105218A. | |
| Ifinatamab | Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2484870-90-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99367. | |
| Ifinatamab deruxtecan | Ifinatamab deruxtecan (DS-7300a) is an ADC that binds an anti-B7-H3 antibody to the DNA topoisomerase I inhibitory anti-tumor drug DXd. Ifinatamab deruxtecan has antitumor activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: DS-7300a; MABX-9001a. CAS No. 2484870-92-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3371. | |
| IFN alpha-IFNAR-IN-1 hydrochloride | IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-? and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-? responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 ?M)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-98-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12836A. | |
| IFN-γ Antagonist 1 | IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) is an antagonist of interferon γ ( IFN γ ). IFN-γ Antagonist 1 inhibits IFN-γ induced HLR/DR antigen expression in Colon 205 cells with an IC 50 value of approximately 35 μM. IFN-γ Antagonist 1 has potential applications in immune regulation [1]. Uses: Scientific research. Group: Peptides. CAS No. 158040-83-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4717. | |
| Ifosfamide | Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors. Uses: Scientific research. Group: Signaling pathways. CAS No. 3778-73-2. Pack Sizes: 200 mg; 500 mg. Product ID: HY-17419. | |
| iFSP1 | iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 150651-39-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-136057. | |
| IgdE protease | IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1892548-76-3. Pack Sizes: 1 KU. Product ID: HY-E70364. | |
| iGOT1-01 | iGOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor. iGOT1-01 has IC50s of 85 ?M and 11.3 ?M in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 882256-55-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124825. | |
| Iguratimod | Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2 , with an IC 50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor ( MIF ) with an IC 50 of 6.81 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: T614. CAS No. 123663-49-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17009. | |
| iHCK-37 | iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 ?M. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 ?M. iHCK-37 is used for chronic myeloid leukemia (CML) research[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASN05260065. CAS No. 516478-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139147. | |
| IHR-1 | IHR-1 is a cell membrane impermeable Smo antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 548779-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110240. | |
| i-Inositol | i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: myo-Inositol; meso-Inositol. CAS No. 87-89-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B1411. | |
| IK-175 | IK-175 is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. IK-175 effectively blocks AHR from translocating from the cytoplasm to the nucleus. IK-175 is highly selective for AHR over other receptors, transporters, and kinases[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 5 free base. CAS No. 2247950-42-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141609. | |
| IK-930 | IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC 50 value of <0.1 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2563892-44-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153585. | |
| Ikarugamycin | Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME) [1]. Uses: Scientific research. Group: Natural products. CAS No. 36531-78-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-119764. | |
| IKK 16 | IKK 16 is a selective I?B kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 873225-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13687. | |
| IKK 16 hydrochloride | IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-?B pathway[1][2][3][4][5][6][7]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186195-62-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13687A. | |
| IKKβ-IN-4 | IKKβ-IN-4 (compound 14) is an IkappaB kinase-β ( IKKβ ) inhibitor with IC 50 value of 1.9 μM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4815-35-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W028127. | |
| IL-17A antagonist 1 | IL-17A antagonist 1 (compound 1) is an IL-17A antagonist, with a Kd of 0.66 ?M and an IC50 of 1.14 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2205034-18-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101913. | |
| IL-17-IN-2 | IL-17-IN-2 (Example 51) is a potent inhibitor of IL-17 , with the IC 50 of < 0.4 μM in HTRF and NHK assay [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3058278-46-6. Pack Sizes: 1 mg. Product ID: HY-168582. | |
| IL-4-inhibitor-1 | IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 μM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1332184-63-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139092. | |
| Ilaprazole | Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H + /K + -ATPase in a dose-dependent manner with an IC 50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IY-81149. CAS No. 172152-36-2. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101664. | |
| Ilaprazole sodium | Ilaprazole (IY-81149) sodium is an orally active proton pump inhibitor. Ilaprazole sodium irreversibly inhibits H + /K + -ATPase in a dose-dependent manner with an IC 50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium is used for the research of gastric ulcers. Ilaprazole sodium is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IY-81149 sodium. CAS No. 172152-50-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2145. | |
| Ilaprazole sodium hydrate | Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor. Ilaprazole sodium hydrate irreversibly inhibits H + /K + -ATPase in a dose-dependent manner with an IC 50 of 6 μM in rabbit parietal cell preparation. Ilaprazole sodium hydrate is used for the research of gastric ulcers. Ilaprazole sodium hydrate is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IY-81149 sodium hydrate. CAS No. 2322264-11-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2145A. | |
| Ilimaquinone | Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus [1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects [2]. Uses: Scientific research. Group: Natural products. CAS No. 71678-03-0. Pack Sizes: 100 μg. Product ID: HY-119500. | |
| Illudin S | Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells[1][2][3][4]. Uses: Scientific research. Group: Natural products. CAS No. 1149-99-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-125098. | |
| Ilomastat | Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1). Uses: Scientific research. Group: Signaling pathways. Alternative Names: GM6001; Galardin. CAS No. 142880-36-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15768. | |
| Iloperidone | Iloperidone (HP 873) is a D 2 /5-HT 2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HP 873. CAS No. 133454-47-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-17410. | |
| Iloprost | Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Ciloprost; ZK 36374. CAS No. 78919-13-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0096. | |
| Ilorasertib | Ilorasertib (ABT-348) is a potent, orally active and ATP-competitive aurora inhibitor with IC 50 s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib also is a potent VEGF , PDGF inhibitor. Ilorasertib has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-348. CAS No. 1227939-82-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16018. | |
| Ilorasertib hydrochloride | Ilorasertib (ABT-348) hydrochloride is a potent, orally active and ATP-competitive aurora inhibitor with IC 50 s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib hydrochloride also is a potent VEGF , PDGF inhibitor. Ilorasertib hydrochloride has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-348 hydrochloride. CAS No. 1847485-91-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16018A. | |
| Ilunocitinib | Ilunocitinib (compound 27) is a JAK inhibitor (extracted from patent WO2009114512A1) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY-3411067. CAS No. 1187594-14-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132819. | |
| Iluzanebart | Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP)[1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: VGL101. CAS No. 2733621-19-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990043. | |
| IM-12 | IM-12 is an inhibitor of GSK-3?, with an IC50 of 53 nM, and also enhances Wnt signalling. Uses: Scientific research. Group: Signaling pathways. CAS No. 1129669-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12292. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.