BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Gepotidacin | Gepotidacin is a potent Type II DNA topoisomerase inhibitor. It is a novel antibacterial drug candidate. It is used for the treatment of gram positive bacterial infection of skin and skin structure. It is also used for the treatment of gonorrhea. It was developed by GlaxoSmithKline R & D and in clinic phase 2 trials. Uses: Gepotidacin is used for the treatment of gram positive bacterial infection of skin and skin structure. it is also used for the treatment of gonorrhea. Synonyms: GSK-2140944; GSK2140944; GSK 2140944; GSK-2140944E; GSK2140944E; GSK 2140944E; Gepotidacin;(2R)-2-[(4-{[(3,4-dihydro-2H-pyrano[2,3-c]pyridin- 6-yl)methyl]amino}piperidin-1-yl)methyl]-1,2-dihydro- 3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione. Grades: >98%. CAS No. 1075236-89-3. Molecular formula: C24H28N6O3. Mole weight: 448.53. |  |
| Gepotidacin S enantiomer | Gepotidacin S enantiomer is an S enantionmer of gepotidacin which is a potent Type II DNA topoisomerase inhibitor and appears as a novel antibacterial drug candidate. Synonyms: Gepotidacin (S enantiomer). Molecular formula: C24H28N6O3. Mole weight: 448.52. | |
| Geranyl bromide | Geranyl bromide (CAS# 6138-90-5) is a chemical reagent used in the synthesis of natural and semisynthetic napthoquinones showing growth inhibitory activity for cancer cell lines. Also used in the synthesis of saicylic acid derivatives showing antimicrobial activity. Synonyms: (2E)-1-bromo-3,7-dimethylocta-2,6-diene. Grades: 98 %. CAS No. 6138-90-5. Molecular formula: C10H17Br. Mole weight: 217.15. | |
| Geranylfarnesol | Geranylfarnesol, isolated from insect wax, is an acyclic C25 isoprenoid alcohol. Geranylfarnesol pyrophosphate is commonly used as a reagent in the biosynth of sesterterpenes. Synonyms: 3,7,11,15,19-Pentamethyleicosa-2E,6E,10E,14E,18-pentaen-1-ol; All-E-geranylfarnesol. Grades: 85%. CAS No. 22488-05-7. Molecular formula: C25H42O. Mole weight: 358.61. | |
| Geranylgeraniol | An intermediate in the lipidation of proteins, which plays a great importance for a variety of biological processes such as cell signalling. Synonyms: Tetraprenol; Geranyl geraniol; (E,E,E)-Geranylgeraniol; trans-Geranylgeraniol; 3,7,11,15-tetramethylhexadeca-2E,6E,10E,14-tetraen-1-ol. Grades: 85%. CAS No. 24034-73-9. Molecular formula: C20H34O. Mole weight: 290.48. | |
| Germanium(II) selenide | Germanium(II) selenide, a widely-used semiconductor material in the optoelectronics industry, presents immense potential in thin film solar cell production and acts as a primary source of germanium and selenium for medical purposes, namely drug delivery and cancer treatments. Synonyms: Germanium(II) selenide; Germanium selenide (GeSe, 5N). Grades: 95%. CAS No. 12065-10-0. Molecular formula: GeSe. Mole weight: 151.6. | |
| GGsTop | GGsTop is a selective and irreversible γ-glutamyl transpeptidase (GGT) inhibitor that inhibits GGT activation and blocks oxidative stress. Study shows that GGsTop pevents ischemia/reperfusion-induced acute kidney injury in rats. Synonyms: GGsTop; GGs-Top; GGs Top; 3-[[ (3-Amino-3-carboxypropyl) methoxyphosphinyl]oxy]benzeneacetic acid; 2-amino-4-[[3-(carboxymethyl)phenoxy]-methoxyphosphoryl]butanoic acid. Grades: ≥95% by HPLC. CAS No. 926281-37-0. Molecular formula: C13H18NO7P. Mole weight: 331.26. | |
| GGTI 2133 trifluoroacetate salt | GGTI 2133 is a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I) with an IC50 value of 38 nM, whch is 140-fold selective for GGTase I over farnesyltransferase (IC50 = 5,400 nM). Synonyms: N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-L-leucine, 2,2,2-trifluoroacetate salt. Grades: ≥95%. CAS No. 1217480-14-2. Molecular formula: C27H28N4O3·xCF3COOH. Mole weight: 456.54. | |
| GGTI 286 trifluoroacetate salt | GGTI 286 is a cell permeable and potent inhibitor of geranylgeranyltransferase I (GGTase I) that selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 and >30 μM, respectively). Synonyms: N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-L-leucine, methyl ester, trifluoroacetate salt. Grades: ≥90%. Molecular formula: C23H31N3O3S·2CF3COOH. Mole weight: 657.62. | |
| GGTI 298 (trifluoroacetate salt) | GGTI-298 is a selective geranylgeranyltransferase type I inhibitor that displays little effect on other prenylation enzymes such as farnesyltransferase. GGTI-298 causes G0-G1 cell cycle block and apoptosis in A549 cells (IC50 = 10 μM for A549 cells) and inhibits cell invasion and migration in COLO 320CM cells. Synonyms: methyl (4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzoyl)-L-leucinate 2,2,2-trifluoroacetate; GGTI-298 TFA; GGTI-298 trifluoride salt; GGTI-298; GGTI 298; GGTI298. CAS No. 1217457-86-7. Molecular formula: C27H33N3O3S.CF3COOH. Mole weight: 593.7. | |
| GHRP-2 | Pralmorelin is an agonist of ghrelin/growth hormone secretagogue (GHS) receptor. It is marketed by Kaken Pharmaceutical in Japan in a single-dose formulation for the assessment of growth hormone deficiency (GHD). Synonyms: Pralmorelin; KP-102; KP 102; KP102; GHRP 2; Growth hormone-releasing peptide 2. CAS No. 158861-67-7. Molecular formula: C45H55N9O6. Mole weight: 817.97. | |
| GHRP-6 | GHRP-6 is a synthetic met-enkephalin analogue that binds to growth hormone secretagogue receptor (GHSR). Synonyms: growth hormone releasing hexapeptide; H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2; GHRP-6 Acetate. Grades: 98%. CAS No. 87616-84-0. Molecular formula: C46H56N12O6. Mole weight: 873.01. | |
| GI 181771 | GI-181771X is a novel effect of oral CCK-1 agonist on fasting and postprandial gastric functions in healthy volunteers. Uses: A novel effect of oral cck-1 agonist. Synonyms: GI-181771X; GI181771X; GI 181771X; GSKI 181771X;GSKI-181771X; GSKI181771X.(S)-3-(3-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)ureido)benzoic acid. Grades: ≥96%. CAS No. 305366-98-7. Molecular formula: C34H31N5O6. Mole weight: 605.22. | |
| GI 254023X | GI 254023X is a selective ADAM10 metalloprotease inhibitor with over 100-fold higher potency at ADAM10 than ADAM17. GI 254023X inhibits the proliferation of H929 cells, and calcium ionophore-induced betacellulin shedding in IMPE cells. It prevents E-cadherin cleavage in A549 cells, and suppresses ADAM10 mediated neuronal outgrowth of dorsal root ganglion neurons in vitro. Synonyms: GI254023X; GI 254023X; GI-254023X;GI4023; GI-4023; GI 4023. (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide. Grades: ≥98% by HPLC. CAS No. 260264-93-5. Molecular formula: C21H33N3O4. Mole weight: 391.5. | |
| GIBH-130 | GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses theIL-1βsecretion by activated microglia (IC50=3.4 nM). GIBH-13 constitutes a unique chemical probe for pathogenesis research and drug development of AD, and it also suggests microglia-based phenotypic screenings that target neuroinflammation as an effective and feasible strategy to identify novel anti-AD agents. Synonyms: (4-methyl-6-phenylpyridazin-3-yl)-(4-pyrimidin-2; -ylpiperazin-1-yl)methanone; (4-methyl-6-phenylpyridazin-3-yl)(4-(pyrimidin-2-yl)piperazin-1-yl)methanone; GIBH-130; GIBH130; GIBH 130. CAS No. 1252608-59-5. Molecular formula: C20H20N6O. Mole weight: 360.41. | |
| Gidazepam | Gidazepam has a 3-fold higher affinity for MBR than for CBR (IC50= 710 and 2200 nmol/L, respectively). Uses: Anticonvulsants. Synonyms: 2-(7-bromo-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl)acetohydrazide; (1-hydrazinocarbonyl)-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine-2-one; gidazepam. CAS No. 129186-29-4. Molecular formula: C17H15BrN4O2. Mole weight: 387.23. | |
| Gimeracil (CDHP) | Cas No. 103766-25-2. | |
| Gingerol | Cas No. 23513-14-6. | |
| Ginkgolide J | Ginkgolide J is extracted from the seed of Ginkgo biloba L. It reduces apoptotic damage in cultured chick embryonic neurons. It contributes to the antioxidant properties of G. biloba. It has the superoxide scavenging effect and neuroprotective effect. Synonyms: 7beta-hydroxyginkgolide a; BN 52024; GinkgolideA, 7-hydroxy-, (7β)-; J Ginkgoli. Grades: >98%. CAS No. 107438-79-9. Molecular formula: C20H24O10. | |
| Ginsenoside F3 | Ginsenoside F3 is extracted from the root of Panax ginseng C. A. Mey. It has immunoenhancing activity by regulating production and gene expression of type 1 cytokines and type 2 cytokines in murine spleen cells. Synonyms: (20S)-20-(6-O-α-L-Arabinopyranosyl-β-D-glucopyranosyloxy)-5α-dammara-24-ene-3β,6α,12β-triol; 3β,6α,12β-Trihydroxy-5α-dammar-24-en-20-yl 6-O-α-L-arabinopyranosyl-β-D-glucopyranoside. Grades: >98%. CAS No. 62025-50-7. Molecular formula: C41H70O13. | |
| Ginsenoside F4 | Ginsenoside F4 is extracted from the root of Panax ginseng C. A. Mey. It has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. It was found to strongly inhibit activation of p38 mitogen-activated protein kinase in signal transduction pathways. Synonyms: Ginsenoside Rg6; (20E)-Ginsenoside F4. Grades: >98%. CAS No. 181225-33-2. Molecular formula: C42H70O12. Mole weight: 767. | |
| Ginsenoside F5 | Ginsenoside F5 is extracted from the root of Panax ginseng C. A. Mey. Synonyms: Chikusetsusaponin L8; (3beta,6alpha,12beta)-3,6,12-Trihydroxydammar-24-en-20-yl 6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranoside. Grades: >98%. CAS No. 189513-26-6. Molecular formula: C41H70O13. | |
| Ginsenoside Ra1 | Ginsenoside Ra1 is a known dammarane-type triterpene saponins isolated from the root of Panax ginseng. Panax ginseng C. A. Meyer (Araliaceae) is a well-known oriental medicinal plant that has been used as a general tonic for thousands of years. Synonyms: β-D-Glucopyranoside, (3β,?12β)?-12-hydroxy-20-[(O-β-D-xylopyranosyl-(1?4)?-O-α-L-arabinopyranosyl-(1?6)?-β-D-glucopyranosyl)?oxy]?dammar-24-en-3-yl 2-O-β-D-glucopyranosyl-; (3β,12β)-12-Hydroxy-20-[(O-β-D-xylopyranosyl-(1?4)-O-α-L-arabinopyranosyl-(1?6)-β-D-glucopyranosyl)oxy]dammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside; Dammarane, β-D-glucopyranoside deriv. Grades: > 98%. CAS No. 83459-41-0. Molecular formula: C58H98O26. Mole weight: 1211.38. | |
| Ginsenoside Ra2 | Ginsenoside Ra2 is a known ginsenoside isolated from the root of Panax ginseng. Previous phytochemical studies on P. ginseng led to the isolation of ginsenosides (triterpenoid saponin glycosides), polyacetylenes, sesquiterpenoids, flavonoids, and polysaccharides. Synonyms: β-D-Glucopyranoside, (3β,?12β)?-12-hydroxy-20-[(O-β-D-xylopyranosyl-(1?2)?-O-α-L-arabinofuranosyl-(1?6)?-β-D-glucopyranosyl)?oxy]?dammar-24-en-3-yl 2-O-β-D-glucopyranosyl-; (3β,12β)-12-Hydroxy-20-[(O-β-D-xylopyranosyl-(1?2)-O-α-L-arabinofuranosyl-(1?6)-β-D-glucopyranosyl)oxy]dammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside; Dammarane, β-D-glucopyranoside deriv. Grades: > 98%. CAS No. 83459-42-1. Molecular formula: C58H98O26. Mole weight: 1211.38. | |
| Ginsenoside Ra3 | Ginsenoside Ra3 is isolated from the root of Panax ginseng. Protopanaxadiol- and protopanaxatriol-type ginsenosides are the major biologically active components of P. ginseng that contribute to its diverse pharmacological effects on the central nervous system, cardiovascular system, endocrine secretion, immune-modulation, metabolism, stress, aging, and cancer. Synonyms: β-D-Glucopyranoside, (3β,?12β)?-12-hydroxy-20-[(O-β-D-xylopyranosyl-(1?3)?-O-β-D-glucopyranosyl-(1?6)?-β-D-glucopyranosyl)?oxy]?dammar-24-en-3-yl 2-O-β-D-glucopyranosyl-; (3β,12β)-12-Hydroxy-20-[(O-β-D-xylopyranosyl-(1?3)-O-β-D-glucopyranosyl-(1?6)-β-D-glucopyranosyl)oxy]dammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside; Dammarane, β-D-glucopyranoside deriv. Grades: > 98%. CAS No. 90985-77-6. Molecular formula: C59H100O27. Mole weight: 1241.41. | |
| Ginsenoside Rd2 | Ginsenoside Rd2 is a composition of roots of Panax ginseng. Ginsenoside Rd is a primary constituent of the ginseng rhizome and the administration of ginsenoside Rd significantly increased the reduced GSHPx and glutathione reductase activity. Synonyms: β-D-Glucopyranoside, (3β,?12β)?-3-(β-D-glucopyranosyloxy)?-12-hydroxydammar-24-en-20-yl 6-O-α-L-arabinopyranosyl-; (3β,12β)-3-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-20-yl 6-O-α-L-arabinopyranosyl-β-D-glucopyranoside; 3-O-Glucosylginsenoside C Y; 3-O-β-D-Glucopyranosylginsenoside C-Y; Ginsenoside C-O. Grades: > 98%. CAS No. 83480-64-2. Molecular formula: C47H80O17. Mole weight: 917.13. | |
| Ginsenoside Rf | Ginsenoside Rf, extracted from the traditional Chinese herb ginseng, is a novel natural anticancer products known for its favorable safety and efficacy profiles. It inhibits Ca2+ channels in mammalian sensory neurons through a mechanism requiring G-proteins, whereas a variety of other ginsenosides were relatively ineffective. It might be useful in itself or as a template for designing additional modulators of neuronal Ca2+ channels. It induces G2/M phase cell cycle arrest and apoptosis in human osteosarcoma MG-63 cells through the mitochondrial pathway. Uses: Anti-arthritic agent. Synonyms: (3b,6a,12b)-3,12,20-Trihydroxydammar-24-en-6-yl-2-O-(b-D-glucopyranosyl)-b-D-glucopyranoside. Grades: >98%. CAS No. 52286-58-5. Molecular formula: C42H72O14. Mole weight: 801.03. | |
| Ginsenoside Rh3 | Ginsenoside Rh3 is isolated from red ginseng and metabolized from ginsenoside Rg5. It can be anti-inflammatory. Uses: Ginsenoside rh3 is isolated from red ginseng and could be used as an anti-inflammatory agent. Synonyms: [(20Z)-12β-Hydroxy-5α-dammara-20(22),24-dien-3β-yl]β-D-glucopyranoside; (3β, 12β,20Z)-12-Hydroxydammara-20(22),24-dien-3-yl-β-D-glucopyranoside. Grades: >98%. CAS No. 105558-26-7. Molecular formula: C36H60O7. Mole weight: 604.86. | |
| Ginsenoside Rh7 | Ginsenoside Rh7 is a new dammarane-type triterpene saponins from the Leaves of Panax ginseng. Panax ginseng is an ancient and famous herbal drug in traditional chinese medicines. Bioactive saponins from natural medicines, a number of dammarane-type triterpene oligoglycosides were found to have anti-cancer, anti-arrhythmia and inhibitory effects on reducing sideeffects of steroid hormones. Synonyms: β-D-Glucopyranoside, (3β,?7β,?12β)?-3,?7,?12-trihydroxydammara-5,?24-dien-20-yl; (3β,7β,12β)-3,7,12-Trihydroxydammara-5,24-dien-20-yl β-D-glucopyranoside. Grades: > 98%. CAS No. 343780-68-7. Molecular formula: C36H60O9. Mole weight: 636.86. | |
| Ginsenoside Rh8 | Ginsenoside Rh8 is a saponin composition of roots of Panax ginseng. Ginsenoside-Rh8 was also obtained as a white powder. Ginsenosides are the primary bioactive components of Asian ginseng and more than 30 ginsenosides were reported from ginseng so far. Ginsenosides Rbl, Rb2, Rc, Rd, Rgl, Rg2, and Re are major constituents of white and red ginsengs, while ginsenosides Rg3, Rgs, and Rg6 are known to be unique constituents of red ginseng. Synonyms: Dammar-24-en-12-one, 20-(β-D-glucopyranosyloxy)-3,6-dihydroxy-, (3β,?6α)-; (3β,6α)-20-(β-D-Glucopyranosyloxy)-3,6-dihydroxydammar-24-en-12-one. Grades: > 98%. CAS No. 343780-69-8. Molecular formula: C36H60O9. Mole weight: 636.86. | |
| Ginsenoside Rk2 | Ginsenoside Rk2 is a new dammarane glycosides isolated from the processed ginseng. Ginseng (Panax ginseng C. A. Meyer, Araliaceae) is one of the most popular herbal medicines in the Orient. The most well known chemical constituent of ginseng is ginsenoside, which is a dammarane glycoside. More than 30 ginsenosides were reported from ginseng so far. Synonyms: (3β,12β)-12-Hydroxydammara-20,24-dien-3-yl β-D-glucopyranoside; 3β,12β-Dihydroxydammar-20(21),24-diene-3-O-β-D-glucopyranoside; PAN 20. Grades: > 98%. CAS No. 364779-14-6. Molecular formula: C36H60O7. Mole weight: 604.86. | |
| Givosiran | Cas No. 1639325-43-1. | |
| GKT137831 | GKT137831 attenuates hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression and blunted reductions in PPARγ in HPAECs and HPASMCs. Synonyms: GKT137831; GKT-137831; GKT 137831; GTK831; GTK-831; GTK 831. Grades: >98%. CAS No. 1218942-37-0. Molecular formula: C21H19ClN4O2. Mole weight: 394.85. | |
| Glabrol | Glabrol is a flavonoid showing inhibition of PTP1B and CYP1B1. Synonyms: Glabrol; 59870-65-4; UNII-E4XEY076JN; E4XEY076JN; (S)-7-Hydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-8-(3-methylbut-2-en-1-yl)chroman-4-one; MLS000697605; (2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one; SMR000470942; 7-Hydroxy-2-(4-hydroxy-3-((E)-3-methyl-but-2-enyl)-phenyl)-8-(3-methyl-but-2-enyl)-1-benzopyran-4-one; 4H-1-BENZOPYRAN-4-ONE, 2,3-DIHYDRO-7-HYDROXY-2-(4-HYDROXY-3-(3-METHYL-2-BUTEN-1-YL)PHENYL)-8-(3-METHYL-2-BUTEN-1-YL)-, (2S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-(methyl-2-butenyl)phenyl)-8-(3-methyl-2-butenyl)-, (2S)-. Grades: 98%. CAS No. 59870-65-4. Molecular formula: C25H28O4. Mole weight: 392.49. | |
| Glafenine | Glafenine is a non-steroidal analgesic agent, shows significant antiinflammatory activity. Uses: Wdely used for the treatment of pains of various origins. Synonyms: 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate; 1-Glyceryl N-(7-chloro-4-quinolyl)anthranilate. Grades: ≥98%. CAS No. 3820-67-5. Molecular formula: C19H17ClN2O4. Mole weight: 372.80. | |
| Glafenine hydrochloride | Glafenine hydrochloride, an anthranilic acid derivative, is a non-narcotic analgesic and non-steroidal anti-inflammatory drug. It is an ABCG2 inhibitor (IC50 = 3.2 μM). Synonyms: 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate;hydrochloride; Glafenine (hydrochloride). CAS No. 65513-72-6. Molecular formula: C19H18Cl2N2O4. Mole weight: 409.26. | |
| Glasdegib | Glasdegib is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway that binds to Smoothened (Smo) and inhibits signal transduction. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model. Synonyms: PF-04449913; PF 04449913; 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea. Grades: >98%. CAS No. 1095173-27-5. Molecular formula: C21H22N6O. Mole weight: 374.44. | |
| Glatiramer acetate | Glatiramer acetate is an immunomodulator drug currently used to treat multiple sclerosis. It is a random polymer of four amino acids found in myelin basic protein, namely L-glutamic acid, L-lysine, L-alanine, and L-tyrosine. Synonyms: Copaxone; Copolymer 1; Copolymer-1. CAS No. 147245-92-9. Molecular formula: C25H45N5O13. Mole weight: 623.657. | |
| Glaucocalyxin B | Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anti-inflammatory effects. Synonyms: HY-N2113. Grades: 98%. CAS No. 80508-81-2. Molecular formula: C22H30O5. Mole weight: 374.47. | |
| Glibenclamide potassium salt | Glibenclamide potassium salt is a salt form of Glibenclamide, a KATP channel blocker used for the treatment of type 2 diabetes. Glibenclamide binds to and inhibits the sulfonylurea receptor 1 (SUR1), the regulatory subunit of the ATP-sensitive potassium channels (KATP) in pancreatic β cells. Uses: Antidiabetic. Synonyms: Glibenclamide potassium salt; Glyburide potassium salt; 23047-14-5; dipotassium; 5-chloro-N-[2-[4-[ (N-cyclohexyl-C-oxidocarbonimidoyl) sulfamoyl]phenyl]ethyl]-2-methoxybenzenecarboximidate; E99010; 5-chloro-N- (4- (N- (cyclohexylcarbamoyl) sulfamoyl) phenethyl) -2-methoxybenzamide potassium. Grades: 99%. CAS No. 23047-14-5. Molecular formula: C23H26ClK2N3O5S. Mole weight: 570.18. | |
| Glimepiride Impurity A | Glimepiride Impurity A is the cis-isomer of Glimepiride found in a bulk drug substance. Glimepiride is an antidiabetic medication used to treat type 2 diabetes. Synonyms: 1-[[p-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-3-(cis-4-methylcyclohexyl)urea; 3-Ethyl-2, 5-dihydro-4-methyl-N- [2- [4- [ [ [ [ (cis-4-methylcyclohexyl) amino] carbonyl] amino] sulfonyl] phenyl] ethyl] -2-oxo-1H-pyrrole-1-carboxamide; Gl. Grades: > 95%. CAS No. 684286-46-2. Molecular formula: C24H34N4O5S. Mole weight: 490.63. | |
| Glimepiride Impurity I | An impurity of Glimepiride, an antidiabetic medication used to treat type 2 diabetes. Synonyms: ortho-Glimepiride Impurity; 3-Ethyl-2, 5-dihydro-4-methyl-N- [2- [2- [ [ [ [ (trans-4-methylcyclohexyl) amino] carbonyl] amino] sulfonyl] phenyl] ethyl] -2-oxo-1H-pyrrole-1-carboxamide; Glimepride 2-Isomer; Glimepiride ortho isomer. Grades: ≥95%. CAS No. 878480-70-7. Molecular formula: C24H34N4O5S. Mole weight: 490.63. | |
| Glipizide | Glipizide is an oral rapid- and short-acting anti-diabetic drug from the sulfonylurea class. Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. Uses: Hypoglycemic agents. Synonyms: 2-Pyrazinecarboxamide, N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -5-methyl-; N- [2- [4- [ [ [ (Cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -5-methyl-2-pyrazinecarboxamide; Pyrazinecarboxamide, N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -5-methyl-; Urea, 1-cyclohexyl-3-[[p-[2- (5-methylpyrazinecarboxamido) ethyl]phenyl]sulfonyl]-; Aldiab; CP 28720; Digrin; Dipazide; Glibenese; Glibetin; Glican; Glidiab; Glipid; Glipizid; Gluco-Rite; Glucolip; Glucotrol; Glucotrol Xl; Glucozide; Glupitel; Glupizide; Glyde; Glydiazinamide; Glynase; K 4024; Melizide; Mindiab; Minidab; Minidiab; Minodiab; N-(4-[β-(5-Methylpyrazine-2-carboxamido)ethyl]benzenesulfonyl)-N'-cyclohexylurea; Napizide; Ozidia; Samarium(III) ionophore I; Semiglynase; Sucrazide; TK 1320. Grades: >98%. CAS No. 29094-61-9. Molecular formula: C21H27N5O4S. Mole weight: 445.54. | |
| Glisoxepide | Glisoxepide, a second-generation sulfonylurea, exerts greater binding affinity than the first-generation compounds. With antihyperglycemic activity, Glisoxepide is used as an antidiabetic drug used in the treatment of diabetes mellitus type 2. Uses: Antidiabetic. Synonyms: N- [2- [4- [ [ [ [ (Hexahydro-1H-azepin-1-yl) amino] carbonyl] amino] sulfonyl] phenyl] ethyl] -5-methyl-3-isoxazolecarboxamide; 4-[4-[β-(5-Methylisoxazole-3-carboxamido)ethyl]phenylsulfonyl]-1,1-hexamethylenesemicarbazide; BS 4231; BS4231; BS-4231; Glisepin; Glisoxepide; Pro-Diaban. Grades: 95%. CAS No. 25046-79-1. Molecular formula: C20H27N5O5S. Mole weight: 449.52. | |
| [Gln4]-Neurotensin | Neurotensin induces contractions in smooth muscle cells, playing a role in regulating digestive activity in vitro and in vivo. Synonyms: 4-Gln-neurotensin; H-Pyr-Leu-Tyr-Gln-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH. Grades: 98%. CAS No. 61445-54-3. Molecular formula: C78H122N22O19. Mole weight: 1671.9. | |
| Glomeratose A | Glomeratose A is a phenylpropanoid isolated from Polygala tenuifolia. Synonyms: GlomeratoseA; BCP25315; FT-0777097. Grades: 98%. CAS No. 202471-84-9. Molecular formula: C24H34O15. Mole weight: 562.52. | |
| GLPG-0187 | GLPG-0187 is a small molecule integrin receptor antagonist (IRA) with nanomolar affinity for the RGD-integrin receptors αvβ1, αvβ3, αvβ5, αvβ6 and α5β1 (IC50s = 1.2-3.7 nM). Integrin receptors are expressed on the surface of tumor vessel endothelial cells and some types of cancer cells, and play a crucial role in endothelial cell adhesion and migration. This compound shows an inhibitory activity of angiogenesis, bone-resorption and tumor, which is hopefully used as an anticancer drug. Uses: An integrin receptor antagonist (ira) can be used as an anticancer drug. Synonyms: GLPG0187; GLPG 0187; GLPG-0187; UNII-43A5P87Z4T; 43A5P87Z4T; SCHEMBL2372722; CHEMBL3319236; (2S) -3-[[2, 5-dimethyl-6-[4- (5, 6, 7, 8-tetrahydro-1, 8-naphthyridin-2-yl) piperidin-1-yl]pyrimidin-4-yl]amino]-2-[ (4-methoxyphenyl) sulfonylamino]propanoic acid. Grades: ≥98 %. CAS No. 1320346-97-1. Molecular formula: C29H37N7O5S. Mole weight: 595.719. | |
| GLPG 0974 | GLPG 0974 is a potent FFA2 antagonist (IC50 = 9 nM) with selectivity for FFA2 over FFA3. It was shown that GLPG 0974 inhibited acetate-induced human neutrophil migration in plasma or buffer, and also suppressed FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Synonyms: GLPG0974; GLPG 0974; GLPG-0974. 4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoic acid. Grades: ≥98% by HPLC. CAS No. 1391076-61-1. Molecular formula: C25H25ClN2O4S. Mole weight: 485. | |
| Glucodigifucoside | Glucodigifucoside is a compound of the steroidal saponins. Synonyms: 3- [ (3S, 5R, 8R, 9S, 10S, 13R, 14S, 17R) -3- [ (3S, 4S, 6S) -3, 4-dihydroxy-6-methyl-5- [ (2S, 3R, 4S, 5S, 6R) -3, 4, 5-trihydroxy-6- (hydroxymethyl) oxan-2-yl]oxyoxan-2-yl]oxy-14-hydroxy-10, 13-dimethyl-1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 15, 16, 17-tetradecahydrocyclopenta [a]phenanthren-17-yl]-2H-furan-5-one. Grades: >98%. CAS No. 2446-63-1. Molecular formula: C35H54O13. Mole weight: 682.804. | |
| Glucosylisomaltol | Glucosylisomaltol is an indicator for browning reaction. Synonyms: 1-[3-(α-D-Glucopyranosyloxy)-2-furanyl]-1-ethanone-3-O-α-D-Glucopyranosyloxy-2-furyl methyl ketone. CAS No. 85559-61-1. Molecular formula: C12H16O8. Mole weight: 288.25. | |
| Glucovanillin | Glucovanillin, a phenolic compound of natural origin, has emerged as a promising antioxidant and anti-inflammatory agent. Remarkably, it exhibits therapeutic potential in the management of neurodegenerative conditions, such as Alzheimer's and Parkinson's disease. Further, glucovanillin has also garnered attention for its antihypertensive effects and its potential use in the treatment of cardiovascular disease. The versatility of glucovanillin warrants further exploration in the scientific community. Synonyms: 4-(b-D-Glucopyranosyloxy)-3-methoxybenzaldehyde; Vanillin 4-O-b-D-glucoside. CAS No. 494-08-6. Molecular formula: C14H18O8. Mole weight: 314.29. | |
| Glutaminase C-IN-1 | Glutaminase C-IN-1, with effect to suppresse breast cancer cell growth and invasive activity in vitro, it is an allosteric, cell-permeable and reversible inhibitor of lutaminase C (IC50 = ~2.5 μM). Synonyms: GLS-IN-968; GLS IN 968; GLSIN968; Glutaminase inhibitor-968; Glutaminase inhibitor 968; GLS inhibitor 968; Glutaminase inhibitor compound 968; 5-[3-bromo-4-(dimethylamino)phenyl]-2,2-dimethyl-1,3,5,6-tetrahydrobenzo[a]phenanthridin-4-one5-(3-bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo(a)phenanthridin-4(1H)-one. CAS No. 311795-38-7. Molecular formula: C27H27BrN2O. Mole weight: 475.42. | |
| Glutapyrone | Glutapyrone is a DHP amino acid used in the antiarrhythmic, neuroprotective, stress-protective and radioprotective remedy. Synonyms: (S)-4-[[(1,3-Dicarboxypropyl)amino]carbonyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-diethyl ester disodium salt. Grades: 99%. CAS No. 92236-42-5. Molecular formula: C19H24N2Na2O9. Mole weight: 470.38. | |
| Glyburide potassium salt | Glyburide is a sulfonylurea receptor 1 (SUR1) inhibitor linked to ATP-sensitive potassium channel Kir6.2 with an IC50 value of 4.3 nM. Synonyms: Glibenclamide; 5-chloro-N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -2-methoxy-benzamide, monopotassium salt. Grades: ≥98%. CAS No. 52169-36-5. Molecular formula: C23H28ClN3O5S·K. Mole weight: 533.1. | |
| Glybuzole | Glybuzole, a benzenesulfonamide derivative, has been found to have antihyperglycemic through stimulating the release of insulin. Synonyms: Glybuzole; Desaglybuzole; Gludiase; Sulfamidothiodiazol; Glybuzole [INN:JAN]; N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide. Grades: 98%. CAS No. 1492-02-0. Molecular formula: C12H15N3O2S2. Mole weight: 297.40. | |
| Glycine, N-(1-iminopentyl)- | N-(1-iminopentyl)glycine, a neurotransmitter analog, has demonstrated agonist activity at both the NMDA and glycine receptors, highlighting its unique properties. Promising clinical results in animal models of stroke have suggested its potential as a critical agent in the treatment of cerebral ischemia and its associated symptoms. The complexity of its action, coupled with its potential therapeutic value, make this compound an essential prospect for further investigation and development. Synonyms: 2-(1-aminopentylideneamino)acetic Acid; N-(1-Iminopentyl)-Glycine; Pentanimidoylamino-acetic acid. Grades: 95%. CAS No. 193140-43-1. Molecular formula: C7H14N2O2. Mole weight: 158.20. | |
| Glycitein | Glycitein is a soybean (yellow cultivar) isoflavonoid. It may be used to study anti-oxidation processes at the level of gene transcription where it increases the binding of transcription factors [nuclear factor-E2-related factor 2 (Nrf2) and c-Jun] to the antioxidant response element (ARE) on HO-1 and NQO1 promoters. Uses: The compund shows an anti-cancer activity. Synonyms: 7-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-; 7-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-chromenone; 4',7-Dihydroxy-6-methoxyisoflavone. Grades: >98%. CAS No. 40957-83-3. Molecular formula: C16H12O5. Mole weight: 284.26. | |
| Glycogen Phosphorylase Inhibitor | Glycogen phosphorylase inhibitor is a cell-permeable inhibitor of human liver glycogen phosphorylase with an IC50 value of 53 nM. It has been used in biological studies to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells. Synonyms: GPI; 2-chloro-4, 5-difluoro-N- [ [ [2-methoxy-5- [ [ (methylamino) carbonyl] amino] phenyl] amino] carbonyl] -benzamide. Grades: ≥98%. CAS No. 648926-15-2. Molecular formula: C17H15ClF2N4O4. Mole weight: 412.8. | |
| Glycyrrhetic Acid 3-O-β-D-Glucuronide | Glycyrrhetic Acid 3-O-β-D-Glucuronide, a naturally-occurring compound derived from licorice root extract, boasts a repertoire of anti-inflammatory and antiviral characteristics. Manifesting potential to curb viral infections (such as influenza and hepatitis), it also effectively treats psoriasis and eczema. Synonyms: Glycyrrhetic acid 3-O-glucuronide. CAS No. 34096-83-8. Molecular formula: C36H54O10. Mole weight: 646.81. | |
| Gly-Glu-Gly | Behold Gly-Glu-Gly, a tripeptide showing promising efficacy as a natural anti-inflammatory agent in biomedical contexts. Its potential is grounded in studies that have explored its aptitude for mitigating oxidative stress and inflammation in numerous diseases including rheumatoid arthritis, asthma, and cerebral ischemia/reperfusion injury. The full extent of its therapeutic potential, however, remains a topic of ongoing research and investigation. Synonyms: Gly-Glu-Gly; H-GLY-GLU-GLY-OH; glycylglutamylglycine. Grades: 98%. CAS No. 50997-16-5. Molecular formula: C9H15N3O6. Mole weight: 261.23. | |
| Gly-His-Lys | Gly-His-Lys is a tripeptide that can form a complex with copper ions. It is used for hair growth and skin care in cosmetics. It is a liver cell growth factor and stimulates hepatic erythropoietic factor production. Synonyms: L-Lysine, glycyl-L-histidyl-; L-Lysine, N2-(N-glycyl-L-histidyl)-; Glycyl-L-histidyl-L-lysine; GHK; GHK Tripeptide; Growth-modulating peptide; Growth-modulating peptide (human); Kollaren; Kollaren BG; Liver cell growth factor; Liver growth factor; NSC 379527; Prezatide; Tripeptide 1. Grades: ≥95%. CAS No. 49557-75-7. Molecular formula: C14H24N6O4. Mole weight: 340.38. | |
| Glymidine | Glycodiazine is a sulfapyrimidine derivative with antihyperglycemic activity used in biological activities to predict human intestinal absorption in drug discovery. Uses: Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. glycodiazine likely binds to atp-sensitive potassium channel receptors on the pancr. Synonyms: 2-Benzenesulfonamido-5-(2-methoxyethoxy)pyrimidine; Glidiazine; Glymidine; N-[5-(2-Methoxyethoxy)-2-pyrimidinyl]benzenesulfonamide. Grades: ≥98%. CAS No. 339-44-6. Molecular formula: C13H15N3O4S. Mole weight: 309.08. | |
| Glyoxalase I inhibitor | Glyoxalase I inhibitor is a potent Glyoxalase I inhibitor, candidate for anticancer agents. Synonyms: Glycine, L-γ-glutamyl-S-[[(4-bromophenyl)hydroxyamino]carbonyl]-L-cysteinyl-, diethyl ester, monohydrochloride (9CI). Grades: >98%. CAS No. 221174-33-0. Molecular formula: C21H30BrClN4O8S. Mole weight: 613.91. | |
| Glyparamide | Glyparamide is a chlorophenyl-containing sulfonylurea with hypoglycemic activity and rarely causes hepatic injury. Synonyms: Glyparamide; 5581-42-0; Glyparamide [USAN]; P-1306; 1-(4-chlorophenyl)sulfonyl-3-[4-(dimethylamino)phenyl]urea; 1-((p-chlorophenyl)sulfonyl)-3-(p-(dimethylamino)phenyl)urea; 4-Chloro-N- ( (4- (dimethylamino) phenyl) carbamoyl) benzenesulfonamide; Benzenesulfonamide, 4-chloro-N-(di-methylamino)phenyl)amino)carbonyl)-; 1-[ ([[ (4-CHLOROPHENYL) SULFONYL]AMINO]CARBONYL) AMINO]-4- (DIMETHYLAMINO) BENZENE. Grades: >98%. CAS No. 5581-42-0. Molecular formula: C15H16ClN3O3S. Mole weight: 353.82. | |
| Gly-Pro-Glu | Gly-Pro-Glu is a neuroprotective agent and the N-terminal tripeptide of IGF-1. Uses: A neuroprotective agent and the n-terminal tripeptide of igf-1. Synonyms: Glycyl-prolyl-glutamic acid; IGF-I (1-3); L-Glutamic acid, N-(1-glycyl-L-prolyl)-. Grades: ≥98%. CAS No. 32302-76-4. Molecular formula: C12H19N3O6. Mole weight: 301.30. | |
| GMC 61-39 | GMC 61-39 is a clozapine-like atypical antipsychotic. Uses: Atypical antipsychotic. Synonyms: [3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepin-8-yl] trifluoromethanesulfonate. Grades: 98%. CAS No. 234113-94-1. Molecular formula: C19H18ClF3N4O3S. Mole weight: 474.88. | |
| GMQ hydrochloride | GMQ hydrochloride is a selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. It alters the pH dependence of ASIC1a and ASIC1b with no effect on the activation curve of ASIC2a. Synonyms: GMQ monohydrochloride; GMQ HCl; NSC-403387 hydrochloride; NSC 403387 hydrochloride; NSC403387 hydrochloride; NSC-403387 HCl; NSC 403387 HCl; NSC403387 HCl; N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride; 1-(4-Methylquinazolin-2-yl)guanidine hydrochloride. Grades: ≥98% by HPLC. CAS No. 5361-15-9. Molecular formula: C10H11N5.HCl. Mole weight: 237.69. | |
| GN 44028 | GN 44028 is a potent HIF-1α inhibitor (IC50 = 14 nM). It suppresses hypoxia-induced HIF-1α transcriptional activity with no effect on HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Synonyms: GN44028; GN 44028; GN-44028; N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine. Grades: ≥98% by HPLC. CAS No. 1421448-26-1. Molecular formula: C18N15N3O2. Mole weight: 305.33. | |
| GNE 2861 | GNE-2861 is a potent and selective inhibitor of the group 2 p21-activated kinases (PAKs; IC50s = 7.5, 126, and 36 nM for PAK4, -5, and -6, respectively). Synonyms: 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol; 1-[2-[3-(2-aminopyrimidin-4-yl)-2-(2-methoxyethylamino)benzimidazol-5-yl]ethynyl]cyclohexan-1-ol. Grades: ≥98% by HPLC. CAS No. 1394121-05-1. Molecular formula: C22H26N6O2. Mole weight: 406.48. | |
| GNE-3500 | GNE-3500 has been found to be a Retinoic acid receptor-related Orphan receptor C agonist that could be probably significant in studies of some inflammatory diseases. Synonyms: GNE-3500; GNE 3500; GNE3500; 1-(4-(3-fluoro-4-(((3S,6R)-3-methyl-1,1-dioxido-6-phenyl-1,2-thiazinan-2-yl)methyl)phenyl)piperazin-1-yl)ethan-1-one. Grades: 98%. CAS No. 1537859-24-7. Molecular formula: C24H30FN3O3S. Mole weight: 459.58. | |
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