BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Ibrutinib Impurity 1 | An impurity of Ibrutinib, a medication used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Synonyms: 1-Piperidinecarboxylic acid, 3-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-, 1,1-diMethylethyl ester, (3R)-; (R)-tert-Butyl 3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate. Grades: > 95%. CAS No. 1022150-11-3. Molecular formula: C27H30N6O3. Mole weight: 486.58. |  |
| Ibuprofen | Ibuprofen is an inhibitor of COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. Synonyms: α-methyl-4-(2-methylpropyl)?-benzeneacetic acid. CAS No. 15687-27-1. Molecular formula: C13H18O2. Mole weight: 206.28. | |
| Ibuprofen piconol | Ibuprofen piconol is an anti-inflammatory agent that can be synthesized from Ibuprofen. It acts as a cyclooxygenase inhibitor. Synonyms: Pimeprofen; Staderm; Vesicum; pyridin-2-ylmethyl 2-[4-(2-methylpropyl)phenyl]propanoate. CAS No. 64622-45-3. Molecular formula: C19H23NO2. Mole weight: 297.4. | |
| Ibutamoren Mesylate | Ibutamoren, also known as MK-677 or L-163,191, is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity. Synonyms: MK-677; MK 677; MK677; Crescendo; MK 0677; MK-0677; MK0677. Grades: >98%. CAS No. 159752-10-0. Molecular formula: C28H40N4O8S2. Mole weight: 624.77. | |
| ICA 110381 | ICA 110381 is a KV7.2/7.3 activator with EC50 value of 0.38 μM. It has anticonvulsive properties in amygdala-kindled rat. It selectively activates human KCNQ2 expressed in Chinese hamster ovary and may be used to study the pharmacological activities. It also decreases neuronal excitability in CA1 hippocampal neurons. Synonyms: ICA 110381; ICA110381; ICA-110381; 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide. Grades: ≥98% by HPLC. CAS No. 325457-99-6. Molecular formula: C12H8Cl2N2O. Mole weight: 267.11. | |
| Icariside I | Icariside I is extracted from the herbs of Epimedium brevicornum Maxim. Synonyms: Icariin I. Grades: >98%. CAS No. 56725-99-6. Molecular formula: C27H30O11. Mole weight: 530.5. | |
| I-CBP 112 | I-CBP112 has been found to be a CBP/p300 bromodomain inhibitor and could reduce the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells. Synonyms: I-CBP112; I-CBP-112; I-CBP 112. 1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one. Grades: ≥98% by HPLC. CAS No. 1640282-31-0. Molecular formula: C27H36N2O5. Mole weight: 468.59. | |
| ICI 185,282 | ICI 185,282 is a potent thromboxane receptor antagonist. Synonyms: ICI-185282; ICI 185282; ICI185282; 5-(Z)-7-(4-o-Hydroxyphenyl-2-trifluoromethyl-1,3 dioxan-cis-5-yl)heptenoic acid. CAS No. 106393-80-0. Molecular formula: C18H21F3O5. Mole weight: 374.36. | |
| ICI 192,605 | ICI 192,605 is a potent thromboxane A2 receptor antagonist. It can reverse vasoconstriction induced by inhibition of NO production and inhibits platelet aggregation, which leads to an increase in TXA2 release. It also inhibits contractile responses to U 46619. Synonyms: ICI 192605 ; ICI192605; ICI-192605. (4Z)-rel-, 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid; 4-Hexenoic acid, 6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-; 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid; (E)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid; rel-(4Z)-6-[(2R,4R,5S)-2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic Acid. Grades: ≥98% by HPLC. CAS No. 117621-64-4. Molecular formula: C22H23ClO5. Mole weight: 402.87. | |
| ICI 63197 | ICI 63197 is a specific and potent cAMP phosphodiesterase IV (PDE 4) inhibitor. Its IC50 value is 35 nM for inhibition of [3H]-rolipram binding to rat brain. It is potent in anatagonizing reserpine-induced hypothermia. It has an antidepressant effect following systemic administration in vivo. Synonyms: ICI 63197; ICI63197; ICI-63197; 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one; 2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo[1,5-a]pyrimidin-5-one. Grades: ≥99% by HPLC. CAS No. 27277-00-5. Molecular formula: C9H13N5O. Mole weight: 207.23. | |
| Iclepertin | Iclepertin, a glycine transporter inhibitor, is an antipsychotic drug. Synonyms: [5-(methanesulfonyl)-2-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]{(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl}methanone; (5-(methylsulfonyl)-2-(((R)-1,1,1-trifluoropropan-2-yl)oxy)phenyl)((1R,5R)-1-(5-(trifluoromethyl)isoxazol-3-yl)-3-azabicyclo[3.1.0]hexan-3-yl)methanone. CAS No. 1421936-85-7. Molecular formula: C20H18F6N2O5S. Mole weight: 512.42. | |
| Icosanal | Synonyms: Icosanal;Eicosanal;2400-66-0;FWBUWJHWAKTPHI-UHFFFAOYSA-N;EINECS219-275-5;AI3-24217. Grades: 95%. CAS No. 2400-66-0. Molecular formula: C20H40O. Mole weight: 296.53. | |
| Icosanamide | Icosanamide, a derivative of fatty acid, displays promise as a therapeutic agent for diverse inflammatory ailments. With its impressive anti-inflammatory attributes, the compound has garnered attention for handling autoimmune diseases and treating conditions such as rheumatoid arthritis. Its efficacy is well-documented in several clinical studies. Synonyms: Eicosanamide; Arachamide. CAS No. 51360-63-5. Molecular formula: C20H41NO. Mole weight: 311.554. | |
| iCRT 14 | iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling. It is thought to directly influence the interaction between β-catenin and TCF4. It also induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Synonyms: iCRT14; iCRT-14; iCRT 14; Wnt inhibitor; CHEMBL3589010; STK155594; 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione. Grades: >98%. CAS No. 677331-12-3. Molecular formula: C21H17N3O2S. Mole weight: 375.44. | |
| iCRT5 | iCRT5 is a Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor (IC50 value of 18 nM for Wnt responsive STF16 luciferase). iCRT5 disrupts the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin. Synonyms: iCRT5; iCRT-5; iCRT 5; 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid; 4-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid; EN300-00774; AC1Q49FJ. Grades: 99%. CAS No. 18623-44-4. Molecular formula: C16H17NO5S2. Mole weight: 367.44. | |
| Idarubicinone | Idarubicinone is a derivative of Daunorubicin, which is an anthracycline antibiotic used in the treatment of acute myeloid and lymphocytic leukemia, with adverse reactions such as cardiotoxicity and bone marrow suppression. Synonyms: 4-demethoxy daunomycinone; (7S,9S)-9-acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione; 4-Demethoxydaunomycinone; Idarubicin aglycone; (+)-4-Demethoxydaunomycinone; 5,12-Naphthacenedione, 9-acetyl-7,8,9,10-tetrahydro-6,7,9,11-tetrahydroxy-, (7S-cis)-; (+)-Idarubicinone; (8S,10S)-7,8,9,10-Tetrahydro-6,8,10,11-tetrahydroxy-8-acetyl-5,12-naphthacenedione. Grades: ≥95%. CAS No. 60660-75-5. Molecular formula: C20H16O7. Mole weight: 368.34. | |
| IDFP | IDFP is an organophosphorus compound that acts as an irreversible inhibitor of MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively. Inhibition of MAGL and FAAH increases anandamide and 2-AG in the brain, resulting in increased cannabinoid signaling and typical cannabinoid behavioral effects in animal studies. Synonyms: Isopropyl Dodecylfluorophosphonate; 1-[fluoro(propan-2-yloxy)phosphoryl]dodecane. Grades: ≥98%. CAS No. 615250-02-7. Molecular formula: C15H32FO2P. Mole weight: 294.4. | |
| IDO-IN-1 | An IDO inhibitor with IC50 of 59 nM, showing activity in Hela cell (IC50 = 12 nM). Synonyms: IDO-IN-1; IDO-IN1; IDO-IN 1. Grades: > 98%. CAS No. 914638-30-5. Molecular formula: C9H7BrFN5O2. Mole weight: 316.09. | |
| IDO-IN-2 | IDO-IN-2 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM. Synonyms: IDO inhibitor 1; 1-[2-[bis(2-methylpropyl)amino]-5-[2-(2H-tetrazol-5-yl)phenyl]phenyl]-3-(4-methylphenyl)urea. CAS No. 1668565-74-9. Molecular formula: C29H35N7O. Mole weight: 497.63. | |
| IDO-IN-3 | A potent IDO inhibitor. Synonyms: IDO-IN-3; IDO-IN3; IDO-IN 3. Grades: > 98%. CAS No. 2070018-30-1. Molecular formula: C11H12BrFN6O2. Mole weight: 359.15. | |
| IDO-IN-4 | A potent IDO1 inhibitor with IC50 of 8 nM in human IDO1/HEK293 cells. Synonyms: IDO-IN-4; IDO-IN4; IDO-IN 4. (1R, 2S) -2- (4- (diisobutylamino) -3- (3- (p-tolyl) ureido) phenyl) cyclopropanecarboxylic acid. Grades: > 98%. CAS No. 1629125-65-0. Molecular formula: C26H35N3O3. Mole weight: 437.57. | |
| IDO-IN-5 | A potent human IDO inhibitor with IC50 of 1-10 μM. Synonyms: IDO-IN-5; IDO-IN5; IDO-IN 5.(1R,4r)-4-((R)-2-((R)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol. Grades: > 98%. CAS No. 1402837-79-9. Molecular formula: C18H21FN2O2. Mole weight: 316.37. | |
| IDO-IN-6 | A potent human IDO inhibitor with IC50 of <1 μM. Synonyms: IDO-IN-6; IDO-IN6; IDO-IN 6.(1S,4r)-4-((S)-2-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol. Grades:> 98%. CAS No. 1402837-76-6. Molecular formula: C18H21FN2O2. Mole weight: 316.37. | |
| IDO-IN-7 | A potent human IDO inhibitor with IC50 of <1 μM. Synonyms: IDO-IN-7; IDO-IN7; IDO-IN 7.(1R,4r)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol. Grades:> 98%. CAS No. 1402837-78-8. Molecular formula: C18H21FN2O2. Mole weight: 316.37. | |
| IDO-IN-8 | A potent human IDO inhibitor with IC50 of 1-10 μM. Synonyms: IDO-IN-8; IDO-IN8; IDO-IN 8.(1S,4r)-4-((S)-2-((R)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol. Grades: > 98%. CAS No. 1402837-77-7. Molecular formula: C18H21FN2O2. Mole weight: 316.37. | |
| IDX899 | IDX899 is a novel next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) with activity against efavirenz-resistant strains. It is used in the treatment of treatment-naive HIV-1-infected subjects. Uses: Idx899 is used in the treatment of treatment-naive hiv-1-infected subjects. Synonyms: GSK 224876 ; GSK-224876 ; GSK224876; IDX-899; IDX 899; IDX899; 5-Chloro-3-[[3-[(E)-2-cyanovinyl]-5-methyl-phenyl]-methoxy-phosphoryl]-1H-indole-2-carboxamide;Methyl (E)-(2-carbamoyl-5-chloro-1H-indol-3-yl)(3-(2-cyanovinyl)-5-methylphenyl)phosphinate;GSK-224876;GSK224876;(R,E)-methyl (2-carbamoyl-5-chloro-1H-indol-3-yl)(3-(2-cyanovinyl)-5-methylphenyl)phosphinate. Grades: 95%. CAS No. 1097733-15-7. Molecular formula: C20H17ClN3O3P. Mole weight: 413.79. | |
| Ifenprodil Tartrate | Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM. Uses: Adrenergic alpha-antagonists. Synonyms: Ifenprodil (tartrate). Grades: >98%. CAS No. 23210-58-4. Molecular formula: 2(C21H27NO2).C4H6O6. Mole weight: 800.98. | |
| IFN alpha-IFNAR-IN-1 | IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor. It inhibits MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM). It exerts immunosuppressive activity by the direct interaction with IFN-&alpha. Uses: Ifn alpha-ifnar-in-1 inhibits mva-induced ifn-α responses by bm-pdcs. it exerts immunosuppressive activity by the direct interaction with ifn-&alpha. Synonyms: IFN-alpha; IFN alpha; IFNAR-IN-1; IFNAR IN 1; IFNARIN1; IFNAR inhibitor 1; IFNAR-inhibitor-1; IFN-alpha and IFNAR interaction inhibitor. Grades: >98%. CAS No. 844882-93-5. Molecular formula: C18H17NS. Mole weight: 279.40. | |
| Ifosfamide | Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. Uses: Antineoplastic agents, alkylating. Synonyms: 2H-1,3,2-Oxazaphosphorin-2-amine, N,3-bis(2-chloroethyl)tetrahydro-, 2-oxide; 2H-1,3,2-Oxazaphosphorine, 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-, 2-oxide; (2-Chloro-ethyl)-[3-(2-chloro-ethyl)-2-oxo-2λ*5*-[1,3,2]oxazaphosphinan-2-yl]-amine; (±)-Ifosfamide; 3-(2-Chloroethyl)-2-(2-chloroethylamino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; A 4942; Asta Z 4942; Cyfos; Holoxan; Holoxan 1000; Ifex; Ifomide; Ifosfamid; Ifosfomide; Ifosphamide; Iphosphamide; Isoendoxan; Isofosfamide; Isophosphamide; Mitoxana; MJF 9325; Naxamide; NSC 109724; Z 4942. Grades: >98%. CAS No. 3778-73-2. Molecular formula: C7H15Cl2N2O2P. Mole weight: 261.09. | |
| IGF-1 LR3 | IGF-1 LR3 is a lengthened analogue of human insulin-like growth factor 1 (IGF-1). Synonyms: Long R3-IGF-1; IGF-1 Long R3; Long arginine 3-IGF-1. Grades: 95%. CAS No. 946870-92-4. Molecular formula: C400H625N111O115S9. Mole weight: 9117.6. | |
| II-B08 | This active molecular is a cell-permeable SHP2 inhibitor which blocks growth factor stimulated hematopoietic progenitor proliferation and ERK1/2 activation. IC50 is 5.5 μM. II-B08 may be therapeutically useful for anticancer and antileukemia treatment in the future. Uses: Anticancer and antileukemia treatment. Synonyms: II-B08; II-B 08; II-B-08. CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. 3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid,CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. Grades: 98%. CAS No. 1143579-78-5. Molecular formula: C33H27N5O4. Mole weight: 557.61. | |
| Ikarisoside F | Ikarisoside F, a flavonol glycoside from Vancouveria hexandra, could bind to AdoHcy hydrolase. Synonyms: Ikarisoside F. Grades: >98%. CAS No. 113558-14-8. Molecular formula: C31H36O14. Mole weight: 632.61. | |
| iKIX1 | iKIX1 is an inhibitor of Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in amnimal models. Synonyms: 2-Cyano-N-{[ (3, 4-dichlorophenyl) carbamothioyl]amino}acetamide. CAS No. 656222-54-7. Molecular formula: C10H8Cl2N4OS. Mole weight: 303.2. | |
| IL-1R Antagonist | IL-1R antagonist is an interleukin-1 receptor homology and a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88), modulating the interaction of MyD88 and IL-1 receptor type I (IL-1RI). In mice with deep partial-thickness scald wound, IL-1R antagonist decreases the expression of inflammation related factors IL-1β and TNF-α and fibrosis related factors TGF-β1, MMP-1, CTGF, and type ? collagen, promoting wound healing and ruducing fibrosis degree. Synonyms: Hydrocinnamoyl-L-valyl Pyrrolidine; N-[(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-yl]-3-phenylpropanamide. Grades: ≥98%. CAS No. 566914-00-9. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
| IL2 | Recombinant human IL - 2; Interleukin-2 is a secreted cytokine, also called IL-2. Aldesleukin (IL-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Synonyms: Iloprost R-isomer; 74843-13-3; 16(R)-Iloprost; 16-(R)-Iloprost; UNII-AHG2128QW6; AHG2128QW6; (5E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid; (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; Pentanoic acid, 5-((3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-, (5E)-; (5e)-5-[(3as,4r,5r,6as)-5-Hydroxy-4-[(1e,3s,4r)-3-Hydroxy-4-Methyloct-1-En-6-Yn-1-Yl]hexahydropentalen-2(1h)-Ylidene]pentanoic Acid; IL2; SCHEMBL21509107; AKOS040755122; PD021248; Q27273925; 5-((3AS,4R,5R,6aS,E)-5-hydroxy-4-((3S,4R,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid. Molecular formula: C22H32O4. Mole weight: 360.5. | |
| IL-7, IL-12, IL-21 | | |
| Ilaprazole sodium | Ilaprazole sodium is the sodium salt form of ilaprazole, a novel proton pump inhibitor (PPI) used in the treatment of duodenal ulcers. Synonyms: IY-81149 sodium. CAS No. 172152-50-0. Molecular formula: C19H17N4NaO2S. Mole weight: 388.42. | |
| ILK-IN-1 | ILK-IN-1, a ILK inhibitor, has been found to restrain the tumor cell growth through regulating signaling pathways related to oncogenesis and tumor progression. IC50: 0.6 μM. Uses: Ilk-in-1 is a ilk inhibitor that has been found to restrain the tumor cell growth through regulating signaling pathways related to oncogenesis and tumor progression. Synonyms: ILK-IN-1; CHEMBL1830587; GTPL8116; SCHEMBL8536228; BDBM50353484; CS-4936; ILK inhibitor 22(1,5); T315(1,5); OSU-T315 (1,5-regioisomer); OSUT315; OSU T315; OSU-T315. Grades: 98%. CAS No. 1333146-24-9. Molecular formula: C30H30F3N5O. Mole weight: 533.59. | |
| Ilonidap | Ilonidap is an anti-Inflammatory agent. No detailed information has been published yet. Uses: Anti-inflammatory agent. Synonyms: Ilonidap; CP-72,133; CP-72133; CP72,133; (3Z)-6-chloro-5-fluoro-3-[hydroxy(thiophen-2-yl)methylidene]-2-oxoindole-1-carboxamide; Ilonidap(USAN/INN); SCHEMBL42518; 135202-79-8; D04506. Grades: 95%. CAS No. 135202-79-8. Molecular formula: C14H8ClFN2O3S. Mole weight: 338.74. | |
| Imazameth | Imazameth, a 2-substituted imidazole derivative, is a selective herbicide that can be widely used for pre- and post-emergence control of certain annual/perennial grasses and broad-leaved weeds. Synonyms: 3-Pyridinecarboxylic acid, 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-methyl-; 2-[4,5-Dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-methyl-3-pyridinecarboxylic acid; 3-Pyridinecarboxylic acid, 2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-methyl-, (±)-; (±)-Imazapic; 2-(4-Isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-methylnicotinic acid; 5-Methyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid; AC 263222; Cadre; Flame; Flame (herbicide); Imazamethapyr; Imazapic; Imazmethapyr; Oroban. Grades: 95%. CAS No. 104098-48-8. Molecular formula: C14H17N3O3. Mole weight: 275.30. | |
| iMDK | iMDK is an inhibitor of midkine (MDK) expression, a growth factor commonly expressed in malignant tumors. iMDK dose-dependently inhibits MDK expression to attenuate certain tumor cell growth. It inhibits PI3K/Akt pathway thus induces apoptosis in MDK-expressing H441 lung adenocarcinoma cells. Uses: Antitumor agent. Synonyms: 3-[2-(4-fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one. Grades: 99%. CAS No. 881970-80-5. Molecular formula: C21H13FN2O2S. Mole weight: 376.4. | |
| Imiquimod | An agonist of TLR7 with immune response modifying activity, Approved for basal cell carcinoma, In Phase III for VIN and CIN, Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. Uses: An immune response modifier. it stimulates the production of interferon-a. Synonyms: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; R-837; S-26308; Aldara; TMX-101; 1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-; 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-ylamine; Aldara; Beselna; Keravort; R 837; R837; S 26308; TMX 101; Zartra; Zyclara. Grades: >98%. CAS No. 99011-02-6. Molecular formula: C14H16N4. Mole weight: 240.30. | |
| Imiquimod hydrochloride | Imiquimod hydrochloride is an immune response modifier. It acts as a toll-like receptor 7 agonist. It is commonly used topically to treat warts on the skin of the genital and anal areas. It is also used to treat certain diseases of the skin, including skin cancers, such as basal cell carcinoma, Bowen's disease, superficial squamous cell carcinoma, some superficial malignant melanomas, and actinic keratosis. It can lead to the activation of Langerhans cells, which subsequently migrate to local lymph nodes to activate the adaptive immune system when applied to skin. Synonyms: R 837 hydrochloride; R837 hydrochloride; R-837 hydrochloride; 1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-, hydrochloride (1:1); 1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-, monohydrochloride; Imiquimod monohydrochloride. Grades: ≥95%. CAS No. 99011-78-6. Molecular formula: C14H17ClN4. Mole weight: 276.76. | |
| IMM 01 | IMM 01 is an agonist of mammalian Diaphanous (mDia)-related formins that inhibits DID-DAD binding (IC50 value 140 nM). Synonyms: Hydrazinecarbothioamide, 2-[(2,4-dihydroxyphenyl)methylene]-N-(1,1-dimethylethyl)-; 2-[ (2, 4-Dihydroxyphenyl) methylene]-N- (1, 1-dimethylethyl) hydrazinecarbothioamide; IMM-01; IMM01; N- (tert-butyl) -2- ( (2-hydroxy-4-oxocyclohexa-2, 5-dien-1-ylidene) methyl) hydrazinecarbothioamide. Grades: 99%. CAS No. 218795-74-5. Molecular formula: C12H17N3O2S. Mole weight: 267.35. | |
| IMP-1088 | IMP-1088 is an inhibitor of N-myristoyltransferase 1 (NMT1) and NMT2 (IC50 = <1 nM for both human enzymes). It prevents rhinoviral replication without inducing cytotoxicity, and inhibits co-translational myristoylation of a specific virus-encoded protein (VP0) to block viral capsid assembly. Synonyms: EX-A2075; 1-(5-{3,4-difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine. Grades: ≥98%. CAS No. 2059148-82-0. Molecular formula: C25H29F2N5O. Mole weight: 453.53. | |
| IMP321 | IMP321 is an antagonist mAb which blocks the LAG-3-mediated inhibitory signal given to tumor infiltrating T cells. This allows the CD8 T cell to generate a better cytotoxic response against cancer cells. Synonyms: IMP321; IMP 321; IMP-321; Anti-LAG-3; Anti-LAG-3 monoclonal antibody; Anti-LAG-3 monoclonal antibody - Bristol-Myers Squibb; Anti-lymphocyte activation gene 3 monoclonal antibody. | |
| Imperialine-D-glucoside | Imperialine-D-glucoside is an alkaloid from Petilium eduardii (Liliaceae). Synonyms: Edpetiline. Grades: >98%. CAS No. 32685-93-1. Molecular formula: C33H53NO8. Mole weight: 591.77582. | |
| Importazole | Importazole is a cell-permeable inhibitor of importin-&beta. Importazole specifically inhibits the function of importin-β, likely by altering its interaction with RanGTP. Synonyms: N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine; Importazole, Importazole hydrochloride, Importazole HCl. CAS No. 662163-81-7. Molecular formula: C20H22N4. Mole weight: 318.42. | |
| IMR-1 | IMR-1 is a small-molecule inhibitor of Mastermind Recruitment-1. IMR-1 inhibits Notch target gene transcription via disrupting recruitment of Mastermind 1 to the Notch transcriptional activation complex on chromatin, thereby suppressing tumor growth. Synonyms: IMR-1; IMR 1; IMR1. Inhibitor of Mastermind Recruitment-1; ethyl 2-[2-methoxy-4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetate. Grades: >98%. CAS No. 310456-65-6. Molecular formula: C15H15NO5S2. Mole weight: 353.407. | |
| Inaxaplin | Inaxaplin is an apolipoprotein L1 (APOL1) function inhibitor. Synonyms: 3-[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl]propanamide; 1H-Indole-3-propanamide, 5,7-difluoro-2-(4-fluorophenyl)-N-[(3S,4R)-4-hydroxy-2-oxo-3-pyrrolidinyl]-. CAS No. 2446816-88-0. Molecular formula: C21H18F3N3O3. Mole weight: 417.38. | |
| INCB024360-analog | Potent competitive inhibitor of IDO1 with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; This INCB024360-analog decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion. Synonyms: INCB-24360; INCB024360; INCB 024360; INCB-024360; indoleamine-2,3-dioxygenase inhibitor INCB024360. Grades: > 98%. CAS No. 914471-09-3. Molecular formula: C9H7ClFN5O2. Mole weight: 271.64. | |
| INCB3344 | INCB3344 is a potent CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively. Synonyms: INCB3344; INCB 3344; INCB-3344; N-(2-(((3S,4S)-1-(4-(Benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide. CAS No. 1262238-11-8. Molecular formula: C29H34F3N3O6. Mole weight: 577.59. | |
| Inclisiran | Cas No. 1639324-58-5. | |
| Indophagolin | Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Synonyms: 5-Bromo-N-[4-Chloro-3-(Trifluoromethyl)Phenyl]-1-(Cyclopropylcarbonyl)-6-Indolinesulfonamide. Grades: 98%. CAS No. 1207660-00-1. Molecular formula: C19H15BrClF3N2O3S. Mole weight: 523.799. | |
| INF39 | INF39 is an irreversible and noncytotoxic NLRP3 inhibitor that may be useful for the Treatment of Inflammatory Bowel Disease. Synonyms: INF39; INF-39; INF 39; ethyl 2-[(2-chlorophenyl)methyl]prop-2-enoate; SCHEMBL4697641; Ethyl 2-(2-chlorobenzyl)acrylate. CAS No. 866028-26-4. Molecular formula: C12H13ClO2. Mole weight: 224.68. | |
| Ingenol-3,4,5,20-diacetonide | Ingenol-3,4:5,20-diacetonide is a natural compound extracted from the seeds of Euphorbia lathyris L. It is an analogue of Ingenol 3-Angelate. Synonyms: (1aR, 7bR)-1aα, 2, 7aα, 13, 14, 14aα-Hexahydro-1, 1, 6, 6, 9, 9, 11, 13α-octamethyl-10aαH-2α, 12aα-methano-1H, 4H-cyclopropa[5, 6][1, 3]dioxolo[2', 3']cyclopenta[1', 2':9, 10]cyclodeca[1, 2-d][1, 3]dioxin-15-one;Ingenol 3,4:5,20-bisacetonide;HY-N0871;CS-3918. Grades: >98%. CAS No. 77573-44-5. Molecular formula: C26H36O5. Mole weight: 428.56. | |
| Ingenol-5,20-acetonide-3-O-angelate | Ingenol-5,20-acetonide-3-O-angelate is a derivative of Ingenol, which is the analogue of Ingenol 3-Angelate. It has anti-tumor activity when used topically for the treatment of actinic keratosis. Uses: Ingenol-5,20-acetonide-3-o-angelate has anti-tumor activity when used topically for the treatment of actinic keratosis. Synonyms: (9R, 12S, 12aS, 12bR)-12a-hydroxy-2, 2, 7, 7, 9, 11-hexamethyl-13-oxo-6, 6a, 7a, 8, 9, 12, 12a, 12b-octahydro-4H, 7H-6, 9a-methanocyclopenta[9, 10]cyclopropa[5, 6]cyclodeca[1, 2-d][1, 3;Ingenol 5,20-acetonide 3-angelate;Ingenol 3-angelate 5,20-acetonide. Grades: >98 %. CAS No. 87980-68-5. Molecular formula: C28H38O6. Mole weight: 470.60. | |
| Ingenol disoxate | Ingenol disoxate is a Novel 4-Isoxazolecarboxylate Ester of Ingenol with Improved Properties. Ingenol is a natural product found in the sap of the plant Euphorbia peplus and it is a inducer of cell death. In Jul 2016, LEO Pharma initiated a phase I trial for Actinic keratosis in USA. Meanwhile, Phase-II clinical trials in Acne vulgaris in USA is on-going. Uses: Acne vulgaris;actinic keratosis. Synonyms: Ingenol disoxate; LEO43204; LEO 43204; LEO-43204. (1aR, 2S, 5R, 5aS, 6S, 8aS, 9R, 10aR) -5, 5a-dihydroxy-4- (hydroxymethyl) -1, 1, 7, 9-tetramethyl-11-oxo-1a, 2, 5, 5a, 6, 9, 10, 10a-octahydro-1H-2, 8a-methanocyclopenta [a]cyclopropa [e] [10]annulen-6-yl 3,5-diethylisoxazole-4-carboxylate; LEO43204. Grades: 98%. CAS No. 1383547-60-1. Molecular formula: C28H37NO7. Mole weight: 499.60. | |
| INH1 hydrochloride | INH1 is a Hec1/Nek2 mitotic pathway inhibitor. It binds to Hec1, induces mitosis arrest and inhibits proliferation in breast cancer cell lines (GI50 = 10-20 μM). Synonyms: N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1780260-01-6. Molecular formula: C18H16N2OS·HCl. Mole weight: 344.86. | |
| Inobrodib | Inobrodib is an inhibitor of the histone acetyltransferase p300 and CREB-binding protein and has antineoplastic activity. Synonyms: (6S)-1-(3,4-difluorophenyl)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]piperidin-2-one; (S)-1-(3,4-difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-((1R,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one; CBP-IN-1; CCS-1477; (6S)-1-(3,4-Difluorophenyl)-6-[5-(3,5-dimethyl-4-isoxazolyl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]-2-piperidinone; CCS 1477; CCS1477. Grades: >98%. CAS No. 2222941-37-7. Molecular formula: C30H32F2N4O3. Mole weight: 534.60. | |
| Integrin Antagonist 1 hydrochloride | Integrin Antagonist 1 hydrochloride, a naphthyridine derivative, is a small molecule antagonist of integrin αvβ6. Synonyms: RGD-mimetic-1; 1-Pyrrolidinebutanoic acid, β-[3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-, (βS,3R)- (hydrochloride). CAS No. 1629249-40-6. Molecular formula: C29H38ClN5O2. Mole weight: 524.10. | |
| Intiquinatine | Intiquinatine may have potential anticancer activity. Uses: May have potential anticancer activity. Synonyms: (R)-2-(4-((7-bromoquinolin-2-yl)oxy)phenoxy)propanoic acid. Grades: ≥98%. CAS No. 445041-75-8. Molecular formula: C18H14BrNO4. Mole weight: 388.21. | |
| Iobenguane sulfate-I-131 | Iobenguane is used in a scintigraphy method called Metaiodobenzylguanidine (MIBG) scan as a radiopharmaceutical. It can localize to adrenergic tissue and thus can be used to identify the location of tumors like phaeochromocytomas and neuroblastomas. Iobenguane can also be used to eradicate tumor cells that take up and metabolize norepinephrine. Phase II Clinical trials for the treatment of Neuroblastoma is on-going. Uses: Neuroblastoma; metaiodobenzylguanidine scan. Synonyms: ((3-(iodo-(sup 123)I)phenyl)methyl)-Guanidine sulfate (2:1). Grades: 98%. CAS No. 139755-80-9. Molecular formula: C16H20[123I]2N6.O4SH2. Mole weight: 640.27. | |
| Ioforminol | Ioforminol is a new low-osmolar dimeric radiographic contrast agent. It exhibits similar preclinical properties to other dimeric radiographic contrast media. It enables an iso-osmolar formulation containing a significantly higher concentration of electrolytes than Visipaque because of the low osmolality. Uses: Ioforminol is a new low-osmolar dimeric radiographic contrast agent and exhibits similar preclinical properties to other dimeric radiographic contrast media. Synonyms: GE-145; GE145; GE 145; AN-113111; AN113111; AN 113111; Ioforminol. 5,5'-((2-hydroxypropane-1,3-diyl)bis(formylazanediyl))bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide);5-[[3-[3,5-Bis(2,3-dihydroxypropylcarbamoyl)-N-formyl-2,4,6-triiodoanilino]-2-hydroxypropyl]-formylamino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide. Grades: >98%. CAS No. 1095110-48-7. Molecular formula: C33H40I6N6O15. Mole weight: 1522.14. | |
| Iothalamic Acid | Iothalamic Acid, similar to those of diatrizoic acid, as conventional ionic contrast medioum Iothalamic Acid displayed the same level of nephrotoxicity against rat and human renal epithelial cells. Synonyms: 3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic acid Acid, Iotalamic Acid, Iothalamic Acid, Methalamic Angio Conray Angio-Conray AngioConray Conray 420 Iodothalamate Iotalamic Acid Iothalamate Iothalamate, Sodium Iothalamic Acid Iothalamic Acid, Calc. Grades: 95%. CAS No. 2276-90-6. Molecular formula: C11H9I3N2O4. Mole weight: 613.91. | |
| Ioversol related compound B | An analog of Ioversol, which has been used as a contrast medium. Synonyms: N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[2-(2-hydroxyethylamino)-2-oxoethoxy]isophthalamide; N,N'-Bis(2,3-dihydroxypropyl)-5-[(N-(2-hydroxyethyl)-carbamoyl)methoxy]-2,4,6-triiodoisophthalamide. Grades: 95 %. CAS No. 104517-96-6. Molecular formula: C18H24I3N3O9. Mole weight: 807.1. | |
| IP7e | IP7e is a potent Nurr1 (NR4A2) activator with EC50 value of 3.9 nM, which is important in the development and maintenance of midbrain dopaminergic neurons and is independent of endogenous activation. It suppresses NF-κB signaling. It reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). It is brain penetrant and orally bioavailable. Synonyms: IP7e; IP 7e; IP-7e; isoxazolo-pyridinone 7e; 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one. Grades: ≥98% by HPLC. CAS No. 500164-74-9. Molecular formula: C23H22N2O4. Mole weight: 390.43. | |
| IPA-3 | IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6). Synonyms: IPA-3; IPA 3; IPA3. Grades: >98%. CAS No. 42521-82-4. Molecular formula: C20H14O2S2. Mole weight: 350.45. | |
| Ipamorelin | Ipamorelin is a ghrelin mimetic displaying growth hormone (GH) releasing activity. Ipamorelin binds to ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain and promotes the GH release. It has been investigated for the treatment of ileus and gastrointestinal dysmotility. Synonyms: NNC-26-0161; NNC 26-0161; NNC26-0161; NNC-260161; NNC 260161; NNC260161. CAS No. 170851-70-4. Molecular formula: C38H49N9O5. Mole weight: 711.85. | |
| IPD Hydrochloride | IPD is an alkylsulfonate DNA crosslinker. Uses: Dna crosslinker. Synonyms: Improsulfan hydrochloride, Improsulfan HCl, Yoshi-864; Yoshi 864; Yoshi864; NSC102627; NSC-102627; NSC 102627azanediylbis(propane-3,1-diyl) dimethanesulfonate hydrochloride; 3-(3-methylsulfonyloxypropylamino)propyl methanesulfonate;hydrochloride. Grades: ≥98%. CAS No. 3458-22-8. Molecular formula: C8H20ClNO6S2. Mole weight: 325.82. | |
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