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Boc-D-Tyr(OtBu)-Aib-Gln(Trt)-Gly-OH is a protected tetrapeptide utilized in peptide synthesis. The Boc (tert-Butoxycarbonyl) group safeguards the N-terminus of the D-tyrosine (D-Tyr) residue, while the OtBu (tert-butyl) group protects the hydroxyl group on the D-tyrosine's side chain, preventing premature reactions during synthesis. The second residue, Aib (α-aminoisobutyric acid), is known for its ability to induce helical conformations in peptides. The Gln (Glutamine) residue has its side chain protected by a Trt (Trityl) group, allowing for selective deprotection later in the synthesis process. The final residue, Gly (Glycine), has a free carboxyl group at the C-terminus, denoted by -OH, which can be used for further coupling or modifications. This peptide is specifically designed to incorporate D-tyrosine, Aib, glutamine, and glycine into peptide structures, with carefully selected protective groups to ensure controlled and efficient synthesis. Synonyms: yXQG; N2-(2-((R)-3-(4-(tert-Butoxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanamido)-2-methylpropanoyl)-N5-trityl-L-glutaminylglycine; Boc-D-Tyr(tBu)-Aib-Gln(Trt)-Gly-OH. Grade: ≥95%. Molecular formula: C48H59N5O9. Mole weight: 850.03.
Boc-D-Tyr(OtBu)-Aib-Glu(OtBu)-Gly-OH
Boc-D-Tyr(OtBu)-Aib-Glu(OtBu)-Gly-OH is a protected tetrapeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the D-tyrosine (D-Tyr) residue, preventing it from reacting during synthesis. The side chain hydroxyl group of D-tyrosine and the carboxyl group of glutamic acid (Glu) are protected by OtBu (tert-butyl) groups, which shield these functional groups until selective deprotection is needed. Aib (α-aminoisobutyric acid), known for its ability to induce helical structures, is the third residue, and Gly (Glycine), the final amino acid, has a free carboxyl group at the C-terminus, indicated by -OH, allowing for further coupling or modifications. This peptide incorporates D-tyrosine, Aib, glutamic acid, and glycine into peptide sequences, with specific protections to ensure controlled and efficient synthesis. Synonyms: yXEG; ((S)-5-(tert-Butoxy)-2-(2-((R)-3-(4-(tert-Butoxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanamido)-2-methylpropanamido)-5-oxopentanoyl)glycine; Boc-D-Tyr(tBu)-Aib-Glu(tBu)-Gly-OH. Grade: ≥90%. Molecular formula: C33H52N4O10. Mole weight: 664.80.
Boc-D-Tyr(OtBu)-Aib-OH
Boc-D-Tyr(OtBu)-Aib-OH is a protected dipeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the D-tyrosine (D-Tyr) residue, preventing unwanted reactions during synthesis. The hydroxyl group on the D-tyrosine side chain is protected by an OtBu (tert-butyl) group, safeguarding it from reactivity until selective deprotection is desired. Aib (α-aminoisobutyric acid) is the second amino acid in the sequence, a non-natural amino acid known for inducing helical structures in peptides. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling. This compound is utilized to introduce D-tyrosine and Aib into peptides, with specific protections ensuring controlled and selective synthesis while incorporating structural constraints. Synonyms: Boc-D-Tyr(tBu)-Aib-OH; N-tert-Butoxycarbonyl-O4-tert-butyl-D-tyrosyl-alpha-methyl-alanine; (R)-2-(3-(4-(tert-Butoxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanamido)-2-methylpropanoic acid. Grade: ≥95%. Molecular formula: C22H34N2O6. Mole weight: 422.52.
BOC-GLN-ALA-ARG-AMC is a highly reactive substrate for trypsin. Synonyms: Boc-QAR-AMC. Grade: 95%. CAS No. 201849-55-0. Molecular formula: C29H43ClN8O8. Mole weight: 667.15.
Boc-Gln-Ala-Arg-pNA
Boc-Gln-Ala-Arg-pNA is a chromogenic substrate for trypsin and matriptase-2. Synonyms: Boc-QAR-pNA; L-Argininamide, N2-[(1,1-dimethylethoxy)carbonyl]-L-glutaminyl-L-alanyl-N-(4-nitrophenyl)-; N2-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-glutaminyl-L-alanyl-N-(4-nitrophenyl)-L-argininamide; N-Boc-Gln-Ala-Arg-p-nitroanilide. Grade: ≥95% by HPLC. CAS No. 1926163-47-4. Molecular formula: C25H39N9O8. Mole weight: 593.63.
Boc-Gln-Arg-Arg-AMC
Boc-QRR-AMC is a substrate for the transmembrane serine protease hepsin, also is used for assaying kexin. Synonyms: Boc-Gln-Arg-Arg-Mca; tert-butyl (S)-5-amino-1-((S)-5-guanidino-1-((S)-5-guanidino-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1,5-dioxopentan-2-ylcarbamate; Boc-QRR-AMC. Grade: 95%. CAS No. 109376-05-8. Molecular formula: C32H49N11O8. Mole weight: 715.81.
Boc-Gln-Gly-Arg-AMC is a peptide substrate for coagulation factor XIIa and trypsin. Synonyms: Boc-Gln-Gly-Arg-MCA. CAS No. 113865-85-3. Molecular formula: C28H40N8O8. Mole weight: 616.67.
BOC-GLN-GLY-ARG-AMC HCL
A fluorogenic substrate for coagulation factor XIIa and trypsin. Synonyms: N-tert-BOC-Gln-Gly-Arg 7-amido-4-methylcoumarin HCl. Grade: 95%. CAS No. 133448-21-2. Molecular formula: C28H41ClN8O8. Mole weight: 653.13.
Substrate for coagulation factors IXa and XIIa as well as for trypsin and soybean trypsin-like enzyme. Synonyms: benzyl (4S)-5-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoate hydrochloride. Grade: ≥ 96% (HPLC). CAS No. 133448-22-3. Molecular formula: C35H45N7O9·HCl. Mole weight: 744.24.
tert-Butyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate has been used as a reactant in the preparation of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 with potential use in osteoarthritis therapy. Synonyms: Boc-Gly-N(OMe)Me; tert-Butyl (2-[methoxy(methyl)amino]-2-oxoethyl)carbamate; N-Boc-glycine N'-methoxy-N'-methylamide; 2-(Boc-amino)-N-methoxy-N-methylacetamide. Grade: ≥ 99 % (HPLC). CAS No. 121505-93-9. Molecular formula: C9H18N2O4. Mole weight: 218.30.
A reagent used in the synthesis of phosphatidyl ethanolamines and ornithine. Synonyms: 2-(Boc-amino)-ethanol; Boc-ethanolamine; N-Boc-ethanolamine; tert-Butyl N-(2-hydroxyethyl)carbamate; tert-butyl (2-hydroxyethyl)carbamate. Grade: ≥ 97 % (Assay). CAS No. 26690-80-2. Molecular formula: C7H15NO3. Mole weight: 161.2.
Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC). Synonyms: Boc-Gly-Gly-Phe-Gly-OH trifluoroacetic acid; N-tert-butoxycarbonyl-glycyl-glycyl-L-phenylalanyl-glycine trifluoroacetic acid. Grade: >98%. Molecular formula: C22H29F3N4O9. Mole weight: 550.48.
Boc-Gly-Tyr-Ome. CAS No. 65160-62-5. Molecular formula: C17H24N2O6. Mole weight: 352.38.
BOC-GRR-AMC
BOC-GRR-AMC is cleaved by type II Metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana. It is a substrate for flavivirus proteases such as West Nile virus protease, yellow fever virus NS3 protease, and dengue virus NS2B-NS3 protease. Synonyms: tert-butyl 2-((S)-5-guanidino-1-((S)-5-guanidino-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-2-oxoethylcarbamate. Grade: 95%. CAS No. 113866-14-1. Molecular formula: C29H44N10O7. Mole weight: 644.72.
Boc-His(Trt)-Aib-Gln(Trt)-Gly-Gly-OH is a protected pentapeptide used in peptide synthesis. It includes histidine (His), α-aminoisobutyric acid (Aib), glutamine (Gln), and two glycine (Gly) residues. The Boc (tert-Butyloxycarbonyl) group protects the N-terminus of the histidine residue, while the Trt (Trityl) groups shield the side chains of histidine and glutamine, preventing premature reactions. The Aib residue adds conformational rigidity, and the two glycine residues at the C-terminus are free, indicated by -OH, allowing for further coupling or modifications. This peptide is designed to ensure controlled reactivity and stability throughout the synthesis process. Synonyms: HXQGG; N2-(2-((S)-2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoyl)-N5-trityl-L-glutaminylglycylglycine. Grade: ≥96%. Molecular formula: C62H66N8O9. Mole weight: 1067.26.
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH
It is the PDC linker targeting moietie of peptide drug conjugates (PDCs). Synonyms: N2-(2-((S)-2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoyl)-N5-trityl-L-glutaminylglycine. Grade: 95%. CAS No. 3034670-38-4. Molecular formula: C60H63N7O8. Mole weight: 1010.19.
Boc-His(Trt)-Aib-Gln(Trt)-OH
Boc-His(Trt)-Aib-Gln(Trt)-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the histidine (His) residue, preventing it from reacting during synthesis. The side chain imidazole group of histidine and the amide group of glutamine (Gln) are protected by Trt (Trityl) groups, shielding these functional groups from unwanted reactions until selective deprotection is performed. Aib (α-aminoisobutyric acid), known for inducing helical structures, is the middle residue. The -OH at the C-terminus of glutamine indicates a free carboxyl group, allowing for further coupling or modifications. This peptide is used to incorporate histidine, Aib, and glutamine into peptides, with specific protections to ensure controlled and efficient peptide synthesis. Synonyms: HXQ; N2-(2-((S)-2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoyl)-N5-trityl-L-glutamine. Grade: ≥95%. Molecular formula: C58H60N6O7. Mole weight: 953.15.
Boc-His(Trt)-Aib-Gly-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the histidine (His) residue, preventing it from reacting during synthesis. The imidazole side chain of histidine is protected by a Trt (Trityl) group, which shields it from unwanted reactions until deprotection is performed. Aib (α-aminoisobutyric acid), known for its helical structure-inducing properties, is the middle residue. Gly (Glycine), the final amino acid, has a free carboxyl group at the C-terminus, indicated by -OH, allowing for further peptide coupling or modifications. This peptide is used to introduce histidine, Aib, and glycine into peptide sequences, with specific protections to ensure controlled and efficient peptide synthesis. Synonyms: HXG; (S)-(2-(2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoyl)glycine. Grade: ≥97%. Molecular formula: C36H41N5O6. Mole weight: 639.75.
Boc-His(Trt)-Gln(Trt)-Gly-OH
Boc-His(Trt)-Gln(Trt)-Gly-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the histidine (His) residue, preventing premature reactions during synthesis. The side chain imidazole group of histidine and the amide group of glutamine (Gln) are protected by Trt (Trityl) groups, shielding these functional groups until selective deprotection is required. Gly (Glycine), the final amino acid in the sequence, has a free carboxyl group at the C-terminus, indicated by -OH, which allows for further peptide coupling or modifications. This compound is used to introduce histidine, glutamine, and glycine into peptides, with controlled protection of functional groups to ensure efficient and precise peptide synthesis. Synonyms: HQG; N2-(Na-(tert-Butoxycarbonyl)-Nt-trityl-L-histidyl)-N5-trityl-L-glutaminylglycine. Grade: ≥96%. Molecular formula: C56H56N6O7. Mole weight: 925.10.