BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| JCP174 | JCP174 is a depalmitoylase inhibitor that targets TgPPT1. JCP174 enhances Toxoplasma tachyzoite invasion into BSC-1 host cells. Synonyms: 7-amino-4-chloro-3-Propoxyisocoumarin; 7-Amino-4-chloro-3-propoxy-1H-isochromen-1-one. Grades: ≥98%. CAS No. 126062-19-9. Molecular formula: C12H12ClNO3. Mole weight: 253.7. |  |
| Jedi2 | Jedi2 is a Piezo1 channel activator that promotes Ca2+ influx into HEK293 cells expressing Piezo1 channels. Synonyms: 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid; 2-Methyl-5-(thien-2-yl)-3-furoic acid; 2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid; 2-methyl-5-(thiophen-2-yl)furan-3-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 651005-90-2. Molecular formula: C10H8O3S. Mole weight: 208.23. | |
| Jervine | Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling. It is an inhibitor of Smo and derived from the Veratrum plant species. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Uses: Antibacterial. Synonyms: Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethyl-, (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-; (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-Hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethylspiro[9H-benzo[a]fluorene-9, 2'(3'H)-furo[3, 2-b]pyridin]-11(1H)-one; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-; Jervin; NSC 23898; NSC 7520; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethyl-, [3S-(3α, 6aα, 6bβ, 9α(3'S*, 3'aR*, 6'R*, 7'aS*), 11aβ, 11bα)]-. Grades: >98%. CAS No. 469-59-0. Molecular formula: C27H39NO3. Mole weight: 425.60. | |
| JH-X-119-01 hydrochloride | A potent IRAK1 inhibitor. Synonyms: JH-X-119-01 (hydrochloride). CAS No. 2591344-30-6. Molecular formula: C25H21ClN6O3. Mole weight: 488.93. | |
| JJH260 | JJH260 is an inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). JJH260 was shown to found members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism. Synonyms: 7-(4-(dimethylamino)benzoyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-chlorophenethyl)piperidine-1-carboxylate. Grades: ≥90%. CAS No. 1831135-30-8. Molecular formula: C29H34ClN5O5. Mole weight: 568.1. | |
| JJKK 048 | JJKK 048, a benzodioxol derivative, has been found to a MAGL inhibitor that could probably be significant in anticancer and anti-inflammatory studies. IC50: 0.4 nM. Synonyms: JJKK048; JJKK-048; JJKK 048; MolPort-035-941-193; BDBM50065646; AKOS025142062; ZINC103287208; [4-[bis(1,3-benzodioxol-5-yl)methyl]piperidin-1-yl]-(1,2,4-triazol-1-yl)methanone. Grades: 98%. CAS No. 1515855-97-6. Molecular formula: C23H22N4O5. Mole weight: 434.44. | |
| JK-184 | JK-184 is a potent downstream hedgehog (Hh) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). Hedgehog signaling plays a key role in a wide variety of developmental processes as well as cancer progression. JK-184 exhibits antiproliferative activity. Uses: Differentiation. Synonyms: JK184; JK 184. Grades: 98%. CAS No. 315703-52-7. Molecular formula: C19H18N4OS. Mole weight: 350.44. | |
| JM-6 | JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO). It could increase kynurenic acid levels and reduces extracellular glutamate in the brain. It prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer disease. It also extends life span, prevents synaptic loss, and decreases microglial activation in a mouse model of Huntington's disease. It also plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including Alzheimer's and Huntington's diseases. Uses: Jm6 plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including alzheimer's and huntington's diseases. Synonyms: JM6; JM-6; JM 6. 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide;2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole. Grades: >98 %. CAS No. 1008119-83-2. Molecular formula: C23H26N4O6S2. Mole weight: 518.60. | |
| JMS 17-2 hydrochloride | JMS 17-2 is a CX3CR1 antagonist. Inhibition of CX3CR1 by JMS 17-2 was indicated to impair metastatic seeding and colonization of breast cancer cells. Synonyms: 5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C25H26ClN3O·HCl. Mole weight: 456.41. | |
| JMV 449 | JMV 449 could be a neurotensin receptor agonist peptide and has been found to show hypothermic and analgesic activities in the mouse. Synonyms: JMV-449; JMV449; (S)-1-de-L-lysine-2-[N2-(2,6-diaminohexyl)-L-lysine]-neuromedin N (pig spinal cord); H-Lysy(CH2NH)Lys-Pro-Tyr-Ile-Leu-OH. Grades: ≥95% by HPLC. CAS No. 139026-66-7. Molecular formula: C38H66N8O7. Mole weight: 746.96. | |
| JNJ-10329670 | JNJ-10329670 represents a novel class of immunosuppressive compounds with a highly potent (Ki ~30 nM). Uses: Immunosuppressant. Synonyms: JNJ-10329670; JNJ 10329670; JNJ10329670. 1-(3-(4-(6-chloro-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)propyl)-4,5,6,7-tetrahydro-5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-1H-Pyrazolo(4,3-C)pyridine. Grades: ≥98%. CAS No. 400797-24-2. Molecular formula: C30H34ClF3N6O3S. Mole weight: 651.14. | |
| JNJ-2408068 | JNJ-2408068 is a potent inhibitor of respiratory syncytial virus (RSV), exhibits potent antiviral activity with 50% effective concentrations (EC50s) of 1.4 and 2.1 nM, respectively. Uses: Respiratory syncytial virus inhibitor. Synonyms: R170591; R-170591; R 170591; HE066500; HE-066500; HE 066500; JNJ-2408068; JNJ 2408068; JNJ2408068. 2-[[2-[[1-(2-aminoethyl)piperidin-4-yl]amino]-4-methylbenzimidazol-1-yl]methyl]-6-methylpyridin-3-ol. Grades: ≥98%. CAS No. 317846-22-3. Molecular formula: C22H30N6O. Mole weight: 394.52. | |
| JNJ26483327 dihydrobromide | JNJ26483327 is an orally bioavailable multitargeted reversible tyrosine kinase inhibitor. It binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, Src family kinases and vascular endothelial growth factor receptor type 3 (VEGFR3). It has potential antineoplastic activity. It may inhibit tumor growth, invasion, migration and metastasis by inhibiting several different signaling molecules. Uses: Jnj26483327 has potential antineoplastic activity and may inhibit tumor growth, invasion, migration and metastasis. Synonyms: (Z)-35-bromo-17-methoxy-5-methyl-13,14-dihydro-11-oxa-2,5-diaza-1(4,6)-quinazolina-3(1,2)-benzenacycloundecaphane;JNJ 26483327; JNJ-26483327; JNJ26483327. Grades: >98 %. CAS No. 1021686-80-5. Molecular formula: C22H27Br3N4O2. Mole weight: 619.19. | |
| JNJ 26854165 dihydrochloride | JNJ 26854165 dihydrochloride is a HDM2 inhibitor. It potently inhibits multiple myeloma (MM) cells and mantle cell lymphoma (MCL). In addition, JNJ 26854165 suppresses the mutant (mut) p53 cell lines and results in apoptosis. Synonyms: Serdemetan dihydrochloride; N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine dihydrochloride. Grades: 99%. CAS No. 2109414-74-4. Molecular formula: C21H20N4.2HCl. Mole weight: 401.33. | |
| JNJ 303 | JNJ 303 has been found to be a potent IKs blocker (IC50 = 64 nM) as well as a 11β-HSD1 inhibitor. Synonyms: JNJ303; JNJ-303; JNJ 303; AC-1; AC 1; AC1; 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3. 3. 1. 13, 7]dec-2-yl]-propanamide. Grades: ≥98% by HPLC. CAS No. 878489-28-2. Molecular formula: C21H29ClN2O4S. Mole weight: 440.98. | |
| JNJ-39327041 | JNJ-39327041 is a bio-active chemical compound. Synonyms: JNJ-39327041; JNJ 39327041; JNJ39327041. N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-1,2-dimethylimidazole-4-sulfonamide;JNJ39327041;1H-Imidazole-4-sulfonamide, N-((4R)-4-(3,4-dimethoxyphenyl)-4-(4-(4-ethyl-1-piperazinyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl)butyl)-1,2-dimethyl-. Grades: 95%. CAS No. 1093069-32-9. Molecular formula: C31H42N6O5S. Mole weight: 610.77. | |
| JNJ-40411813 | JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. Synonyms: JNJ-40411813; JNJ 40411813; JNJ40411813; ADX71149; ADX 71149; ADX-71149. Grades: >98%. CAS No. 1127498-03-6. Molecular formula: C20H25ClN2O. Mole weight: 344.88. | |
| JNJ-42165279 | JNJ-42165279 is a fatty acid amide hydrolase (FAAH) inhibitor developed by Janssen Pharmaceutica and IC50 value is 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH. Phase II human trials for the treatment of anxiety disorders and major depressive disorder is on-going. Uses: Anxiety disorders and major depressive disorder. Synonyms: N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide; JNJ-42165279; JNJ 42165279; JNJ42165279. Grades: 98%. CAS No. 1346528-50-4. Molecular formula: C18H17ClF2N4O3. Mole weight: 410.81. | |
| JNJ-42165279 hydrochloride | JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. Synonyms: JNJ-42165279 hydrochloride; JNJ 42165279 hydrochloride; JNJ42165279 hydrochloride; 1-Piperazinecarboxamid?e, N-(4-chloro-3-pyridinyl)?-4-[(2,?2-difluoro-1,?3-benzodioxol-5-yl)?methyl]?-, hydrochloride (1:1). CAS No. 1346528-52-6. Molecular formula: C18H17ClF2N4O3. HCl. Mole weight: 447.3. | |
| JNJ-42259152 | This molecular is a phosphodiesterase 10A PET tracer. Related studies show that PDE10A activity can be reliably quantified and simplified using a reference tissue model with the frontal cortex as reference and a 60-min acquisition period. Uses: Phosphodiesterase 10a pet tracer. Synonyms: JNJ-42259152; JNJ 42259152; JNJ42259152. UNII-B1QHA9M0I6;2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine. Grades: 98%. CAS No. 1301167-87-2. Molecular formula: C24H23FN4O. Mole weight: 402.46. | |
| JNJ 42396302 | JNJ 42396302 is an Antipsychotics originated by Janssen-Cilag. But no development has been reported yet. Uses: Antipsychotics. Synonyms: JNJ 42396302; JNJ42396302; JNJ-42396302. UNII-P5M4972608;3-(6-(2-methoxyethyl)-3-pyridinyl)-2-methyl-8-(4-morpholinyl)-Imidazo(1,2-b)pyridazine. Grades: 98%. CAS No. 1298030-18-8. Molecular formula: C19H23N5O2. Mole weight: 352.43. | |
| JNJ-64619178 | JNJ-64619178 is a selective PRMT5 inhibitor with potent in vitro and in vivo activity. JNJ-64619178 binds simultaneously to the SAM- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. It can be developed as the treatment of some malignancies. Uses: Enzyme inhibitors. Synonyms: (1S,2R,3S,5R)-3-[2-(2-Amino-3-bromoquinolin-7-yl)ethyl]-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol. CAS No. 2086772-26-9. Molecular formula: C22H23BrN6O2. Mole weight: 483.36. | |
| JNJ7925476 HCl | JNJ7925476 HCl is a novel triple monoamine uptake inhibitor. It blocks the serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT) in the central nervous system. Its ED50 values for SERT, NET, and DATwere 0.18, 0.09 and 2.4 mg/kg, respectively in rat brain. It is used as a TRI antidepressant. It was under the development by Johnson & Johnson. Uses: Jnj7925476 hcl is used as a tri antidepressant. Synonyms: JNJ-7925476; JNJ 7925476; JNJ7925476; JNJ-7925476 HCl. Pyrrolo(2,1-a)isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, hydrochloride (1:1), (6R,10bS)-rel-;Pyrrolo(2,1-a)isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, hydrochloride, trans-;JNJ-7925476 HCl;(6S,10bR)-6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline hydrochloride. Grades: >98%. CAS No. 109085-56-5. Molecular formula: C20H20ClN. Mole weight: 309.84. | |
| JPH203 dihydrochloride | JPH203 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1), which is highly expressed in many tumor cells. Study has shown that JPH203 inhibited L-leucine uptake, and increased apoptosis rates and formed DNA ladder in Saos2 cells. Synonyms: KYT 0353; O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride; (2S)-2-amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochloride. Grades: ≥96% by HPLC. CAS No. 1597402-27-1. Molecular formula: C23H19Cl2N3O4·2HCl. Mole weight: 545.24. | |
| (+)-JQ1 carboxylic acid | (+)-JQ1 carboxylic acid is the carboxylic acid form of BET bromodomain inhibitor (+)-JQ1. Synonyms: JQ-1 carboxylic acid; (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetic acid. Grades: ≥98%. CAS No. 202592-23-2. Molecular formula: C19H17ClN4O2S. Mole weight: 400.881. | |
| JTE 607 dihydrochloride | The hydrochloride salt form of JTE 607, which has been found to be a cytokine release inhibitor. Synonyms: JTE 607 dihydrochloride; JTE607 dihydrochloride; JTE-607 dihydrochloride; N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride. Grades: ≥98% by HPLC. CAS No. 188791-09-5. Molecular formula: C25H31Cl2N3O5.2HCl. Mole weight: 597.36. | |
| JTP 103237 | JTP 103237 is a potent and selective monoacyglycerol acyltransferase 2 (MGAT2) inhibitor (IC50 = 20-40 nM), exhibiting >7000-fold selectivity for human MOGAT2 over human DGAT2. In a high sucrose very low fat (HSVLF) diet induced fatty liver model, JTP-103237 reduced hepatic triglyceride content and hepatic MGAT activity, suppressed not only triglyceride (TG) and diacylglycerol (DG) synthesis, but also fatty acid (FA) synthesis (de novo lipogenesis). Synonyms: 7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine. Grades: ≥98% by HPLC. CAS No. 1883864-16-1. Molecular formula: C24H29F3N6O. Mole weight: 474.52. | |
| JTP-4819 | JTP-4819, a pyrrolidine derivative, has been found to be a PEP inhibitor that was once studied in cognition disorders and had been already been discontinued. Synonyms: JTP-4819; JTP 4819; JTP4819. CHEMBL76578; (2S)-N-benzyl-2-[(2S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxamide; SCHEMBL194809; ICULFJDHZQTNRB-HOTGVXAUSA-N. Grades: 98%. CAS No. 162203-65-8. Molecular formula: C19H25N3O4. Mole weight: 359.43. | |
| JTV 519 fumarate | The fumarate salt form of JTV 519, which has been found to be a Ryanodine receptor (RyR) inhibitor and also could be a useful intermediate. Synonyms: JTV 519 fumarate; JTV519 fumarate; JTV-519 fumarate; 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate. Grades: ≥98% by HPLC. CAS No. 1883549-36-7. Molecular formula: C25H32N2O2.C4H4O4. Mole weight: 540.67. | |
| JW 480 | JW 480 has been found to be a potent and selective inhibitor of KIAA1363 (AADACL1), which is a kind of serine hydrolase enzyme. Synonyms: JW 480; JW480; JW-480; 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate. Grades: ≥98% by HPLC. CAS No. 1354359-53-7. Molecular formula: C22H23NO2. Mole weight: 333.42. | |
| JW 618 | JW 618 is an inhibitor of monoacylglycerol lipase (MAGL), displaying IC50 values of 123, 385, and 6.9 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. MAGL is a 33 kDa serine hydrolase that catalyses the hydrolysis of monoacylglycerols to their corresponding fatty acids. Synonyms: 1,1,1,3,3,3-hexafluoropropan-2-yl N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate. Grades: ≥98%. CAS No. 1416133-88-4. Molecular formula: C17H14F6N2O2. Mole weight: 392.3. | |
| JW 642 | Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively. JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively). Synonyms: JW642; JW-642; JW 642. Grades: >98%. CAS No. 1416133-89-5. Molecular formula: C21H20F6N2O3. Mole weight: 462.39. | |
| JZL184 | JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM. Synonyms: JZL184; JZL 184; JZL-184. Grades: >98%. CAS No. 1101854-58-3. Molecular formula: C27H24N2O9. Mole weight: 520.49. | |
| JZP 361 | JZP 361 is a reversible, potent and selective inhibitor of human recombinant MAGL (hMAGL) with IC50 value of 46 nM. It shows affinity for H1 receptors but shows no activity at cannabinoid receptors. It has MAGL-inhibitory and antihistaminergic and may be a novel dual-acting pharmacological tool. Synonyms: JZP-361; JZP 361; JZP361; [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone. Grades: ≥99% by HPLC. CAS No. 1680193-80-9. Molecular formula: C22H20ClN5O. Mole weight: 405.88. | |
| JZP-430 | JZP-430, a thiadiazol derivative, has been found to be an ABHD6 inhibitor that could probably be effective in obesity and type?II diabetes therapy. IC50: 44 nM. Synonyms: JZP-430; JZP 430; JZP430; 4-morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate. Grades: 98%. CAS No. 1672691-74-5. Molecular formula: C16H26N4O3S. Mole weight: 354.47. | |
| K145 | K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30±0.06 μM. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti-tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model. Synonyms: SphK2 inhibitor; K 145; K-145. Grades: >98%. CAS No. 1309444-75-4. Molecular formula: C18H24N2O3S. Mole weight: 348.46. | |
| K145 hydrochloride | K145 (3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is a selective inhibitor of sphingosine kinase-2 (SphK2) and an anticancer agent. K145 selectively inhibited SphK2 in a dose-dependent manner with an IC50 of 4.30 +/- 0.06 μM with no inhibition of SphK1 at concentrations up to 10 μM. K145 significantly suppressed the growth of U937 tumors in nude mice and the growth of JC tumor cells in BALB/c mice. Synonyms: SphK2 inhibitor; K 145 hydrochloride; K-145 hydrochloride. Grades: >98%. CAS No. 1449240-68-9. Molecular formula: C18H25ClN2O3S. Mole weight: 384.92. | |
| K67 | K67 is a specific inhibitor that inhibits the interaction between the DC domain of KEAP1 and the S349 phosphorylated KIR of p62/SQSTM1. Synonyms: N,N'-[2-(2-Oxopropyl)Naphthalene-1,4-Diyl]Bis(4-Ethoxybenzenesulfonamide). Grades: ≥98% by HPLC. CAS No. 2046250-48-8. Molecular formula: C29H30N2O7S2. Mole weight: 582.7. | |
| K6PC-5 | K6PC-5 is a Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, an active metabolite of sphingolipid. S1P can modulate multiple cellular responses including [Ca2+] signaling, growth, survival, and differentiation. K6PC-5 regulates both differentiation and proliferation of keratinocytes via [Ca2+]i responses through S1P production, which may be used for the treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis. Uses: Potential treatment of skin disorders with abnormal differentiation and proliferation. Synonyms: K6PC-5; K6PC 5; K6PC5; Dihydroxyisopropyl capryloylcaprylamide; Decanamide, 2-hexyl-N-(2-hydroxy-1-(hydroxymethyl)ethyl)-3-oxo. Grades: 98%. CAS No. 756875-51-1. Molecular formula: C19H37NO4. Mole weight: 343.5. | |
| K-7174 | K-7174 is a novel orally active, potent proteasome inhibitor. K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. K-7174 kills bortezomib-resistant myeloma cells carrying a β5-subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K-7174 is also a GATA-specific inhibitor, which may have potential application in treating anemia of chronic disease. Synonyms: K-7174; K 7174; K7174. Grades: 0.98. CAS No. 191089-59-5. Molecular formula: C33H48N2O6. Mole weight: 568.74. | |
| Kaempferol-3-Glucuronide | Kaempferol-3-beta-O-glucuronide is a flavonoid glucuronide, which can be found in vegetables and deconjugated by microsomal β-glucuronidase from various human cells. Uses: Antioxidant. Synonyms: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl-beta-D-glucopyranosiduronic acid. Grades: >98%. CAS No. 22688-78-4. Molecular formula: C21H18O12. Mole weight: 462.36. | |
| Kaempferol 3-sophoroside-7-rhamnoside | Kaempferol 3-sophoroside-7-rhamnoside is a compound of the flavonoid class found in the herbs of Elaeagnus multiflora Thunb. Grades: >98%. CAS No. 93098-79-4. Molecular formula: C33H40O20. Mole weight: 756.66. | |
| Kaempferol-7-O-glucoside | Kaempferol-7-O-β-D-glucopyranoside is extracted from the herbs of Hosta plantaginea. Synonyms: 2-(4-Hydroxyphenyl)-3,5-dihydroxy-7-(β-D-glucopyranosyloxy)-4H-1-benzopyran-4-one; 7-[(β-D-Glucopyranosyl)oxy]-3,4',5-trihydroxyflavone; Kaempferol 7-monoglucoside; 7-(β-D-Glucopyranosyloxy)-3,5-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Glucosyl-7-kaempferol; Populnin. Grades: >98%. CAS No. 16290-07-6. Molecular formula: C21H20O11. | |
| KAI-407 | KAI-407, an imidazopyrazine derivative, has been found to be probably effective to restrain plasmodium and used against malaria. Synonyms: KAI-407; KAI 407; KAI407; N-(4-cyanophenyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide. Grades: 98%. CAS No. 1513879-18-9. Molecular formula: C22H14F3N5O. Mole weight: 421.38. | |
| Kainic acid | Kainic acid is a naturally occurring neuroexcitatory amino acid. It is a selective agonist for a subtype of ainate-class ionotropic glutamate receptor found in seaweed. It increases production of mitochondrial dysfunction, reactive oxygen species and apoptosis in neurons in many regions of the brain. It increases glutamate release and stimulates Na channels, inducing epileptic seizures and neurocytosis (apoptosis). It has been used to study mechanisms of apoptosis and epilepsy. Uses: Excitatory amino acid agonists. Synonyms: (2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid; 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine; (-)-α-Kainic Acid; Digenic Acid; Digenin; Helminal; L-α-Kainic Acid; α-Kainic Acid. Grades: ≥98% by HPLC. CAS No. 487-79-6. Molecular formula: C10H15NO4. Mole weight: 213.23. | |
| Kalopanaxsaponin H | Kalopanaxsaponin H is extracted from the herbs of Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. It has antidiabetic activity. Synonyms: Macranthoside A. Grades: >98%. CAS No. 128730-82-5. Molecular formula: C47H76O17. Mole weight: 913.1. | |
| Karakoline | Alkaloid , from plants of the Ranunculaceae family. Ganglioblocker; nicotinic receptor antagonist; hypotensive; presents micromolar affinity at brain a Bungarotoxin-sensitive nAChR. (See attached sheet.). Synonyms: (16S)-20-Ethyl-16-methoxy-4-methylaconitane-1α,8,14α-triol. Grades: 97% (TLC). CAS No. 39089-30-0. Molecular formula: C22H35O4N. Mole weight: 377.52. | |
| Kartogenin | Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBF&beta. Synonyms: KGN; 2-([1,1'-Biphenyl]-4-ylcarbamoyl)benzoic acid; 2-[(4-phenylphenyl)carbamoyl]benzoic acid. Grades: >98%. CAS No. 4727-31-5. Molecular formula: C20H15NO3. Mole weight: 317.344. | |
| KAT681 | KAT681 is a novel liver-selective thyromimetic displaying strong hypolipidemic properties without cardio-toxic effects. Synonyms: T 0681; T-0681; T0681; Propanoic acid, 3-[[4-[3-[(4-fluorophenyl)?hydroxymethyl]?-4-hydroxyphenoxy]?-3,?5-dimethylphenyl]?amino]?-3-oxo-, sodium salt (1:1). CAS No. 373641-87-3. Molecular formula: C24H22FNNaO6. Mole weight: 462.42. | |
| Kauniolide | Kauniolide is a natural compound. Synonyms: Kauniolide; 81066-45-7; (3aS,9aS,9bS)-6,9-dimethyl-3-methylene-3a,4,5,7,9a,9b-hexahydroazuleno[4,5-b]furan-2(3H)-one; (3aS,9aS,9bS)-6,9-dimethyl-3-methylidene-3a,4,5,7,9a,9b-hexahydroazuleno[4,5-b]furan-2-one; HY-N0843; AKOS030526906; MS-23313; (3aS,9aS,9bS)-6,9-dimethyl-3-methylidene-2H,3H,3aH,4H,5H,7H,9aH,9bH-azuleno[4,5-b]furan-2-one. Grades: >98%. CAS No. 81066-45-7. Molecular formula: C15H18O2. Mole weight: 230.3. | |
| kb NB 142-70 | kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC50 for inhibition of PKD1=28.3 nM vs. 182 nM for CID755673). kb-NB142-70 dose dependently inhibits proliferation of PC3 prostate cancer cell, and blocks migration of the prostate cancer lines PC3 and DU145. Synonyms: kb NB 142-70; kb NB142-70; kb NB-142-70. Grades: >98%. CAS No. 1233533-04-4. Molecular formula: C11H9NO2S2. Mole weight: 251.32. | |
| kb-NB77-78 | kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor). Synonyms: 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-b]pyridin-5-one; kb-NB77-78; kb-NB-77-78; kb-NB 77-78; kb-NB7778; kb-NB-7778; kb-NB 7778. Grades: >98%. CAS No. 1350622-33-1. Molecular formula: C18H25NO3Si. Mole weight: 331.48. | |
| KC01 | KC01 is a selective ABHD16A inhibitor (IC50s values of 90 and 520 nM for human and mouse, respectively). ABHD12 is a major brain Lysophosphatidylserine (lyso-PS) lipase. KC01 was shown to deplete lyso-PSs from cells, including the neurological disease PHARC subject-derived lymphoblasts. Synonyms: (Z)-6-(2-Oxo-4-tridecyloxetan-3-ylidene)hexanamide. Grades: ≥98%. CAS No. 1646795-59-6. Molecular formula: C22H39NO3. Mole weight: 365.6. | |
| KC02 | KC02 is an inactive control probe for KC01, the inhibitor of ABHD16A. Synonyms: 6-(2-Oxo-4-phenethyloxetan-3-ylidene)hexanamide. Grades: ≥98%. CAS No. 1646795-60-9. Molecular formula: C17H21NO3. Mole weight: 287.4. | |
| KCC 07 | KCC 07 is an MBD2 (Methyl-CpG-binding domain protein 2) inhibitor that prevents binding of MBD2 to methylated DNA and reactivates ADGRB1 expression. Synonyms: 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol. Grades: ≥98% by HPLC. CAS No. 315702-75-1. Molecular formula: C14H11N3OS. Mole weight: 269.32. | |
| KD025 | KD025 is an orally available and selective ROCK2 inhibitor with IC50 value of 60 nM and Ki value of 41 nm, respectively. It was shown to suppress adipogenesis in human adipose-derived stem cells. Uses: Protein kinase inhibitors. Synonyms: SLx 2119; SLx2119; KD-025; 2-[3-[4-(1H-indazol-5-ylamino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide. Grades: >98%. CAS No. 911417-87-3. Molecular formula: C26H24N6O2. Mole weight: 452.51. | |
| KDU691 | KDU691 is a plasmodium PI4K inhibitor (IC50 values of 0.18 μM and 0.061 μM against hypnozoite forms and liver schizontsm, respectively) that inhibits dihydroartemisinin-pretreated plasmodium falciparum ring-stage parasites. Synonyms: KDU691; KDU-691; KDU 691; HY-12912; HY 12912; HY12912; N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide. Grades: 98%. CAS No. 1513879-19-0. Molecular formula: C22H18ClN5O2. Mole weight: 419.86. | |
| Kenpaullone | Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680 nM), CDK2/cyclin E (IC50 = 7.5 uM) and CDK5/p25 (IC50 = 850 nM). Kenpaullone inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 μM respectively). Uses: Reprogramming. Synonyms: NSC664704; NSC-664704; NSC 664704; 9-Bromopaullone; 1-azakenpaullone; Kenpaullone. Grades: 98%. CAS No. 142273-20-9. Molecular formula: C16H11BrN2O. Mole weight: 327.18. | |
| Ketotifen Fumarate | Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis,or the itchy red eyes caused by allergies. In its oral form, it is used to preventasthma attacks. Uses: Antipruritics. Synonyms: Zaditen; Zaditor. Grades: >98%. CAS No. 34580-14-8. Molecular formula: C19H19NOS.C4H4O4. Mole weight: 425.5. | |
| KF 13218 | KF 13218, a novel pyridobenzazepinone derivative, inhibited human and bovine platelet thromboxane synthase with IC50 values of 27 +/- 5.8 nmol/l (mean +/- S.E.M.) and 36 +/- 6.9 nmol/l, respectively. Synonyms: (6Z)-6-(6-methyl-5-oxopyrido[4,3-c][1]benzazepin-11-ylidene)hexanoic acid; 11-(5-carboxypentylidene)-6-methyl-5,11-dihydropyrido(4,3-c)(1)benzazepin-5(6H)-one; KF 13218; KF-13218; KF13218. CAS No. 127654-03-9. Molecular formula: C20H20N2O3. Mole weight: 336.38. | |
| KF 38789 | KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion with IC50 value of 1.97 μM. It shows no effects on E-selectin-mediated and L-selectin- adhesion. It blocks leukocyte accumulation in vivo and P-selectin-mediated binding in vitro. It also inhibits the binding of U937 cells to immobilized P-selectin IgG chimeric protein with an IC50 value of 1.97 μM. Synonyms: KF 38789; KF38789; KF-38789; 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one. Grades: ≥97% by HPLC. CAS No. 257292-29-8. Molecular formula: C19H21NO5S. Mole weight: 375.44. | |
| KHK-IN-1 | KHK-IN-1, a pyrimidinopyrimidine derivative, is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on Asp-27B in the ATP-binding region at some extent. Uses: Khk-in-1 is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on asp-27b in the atp-binding region at some extent. Synonyms: KHK-IN-8; KHK IN 8; KHKIN8; KHK inhibitor 8; KHK-inhibitor-8; Ketohexokinase Inhibitor 8; ketohexokinase inhibitor. Grades: 98%. CAS No. 1303469-70-6. Molecular formula: C21H26N8S. Mole weight: 422.55. | |
| KHK-IN-1 hydrochloride | The hydrochloride salt form of KHK-IN-1 which is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on Asp-27B in the ATP-binding region at some extent. Uses: The hydrochloride salt form of khk-in-1 which is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on asp-27b in the atp-binding region at some extent. Synonyms: MDK-0485; MDK0485; MDK 0485; ketohexokinase inhibitor. Grades: 98%. CAS No. 1303470-48-5. Molecular formula: C21H27ClN8S. Mole weight: 459.01. | |
| KHS101 | KHS101 is a selective inducer of neuronal differentiation. Synonyms: N4-Isobutyl-N2-((2-Phenylthiazol-4-Yl)Methyl)Pyrimidine-2,4-Diamine; KHS-101; N4-(2-Methylpropyl)-N2-[(2-Phenyl-1,3-Thiazol-4-Yl)Methyl]Pyrimidine-2,4-Diamine. Grades: 98%. CAS No. 1262770-73-9. Molecular formula: C18H21N5S. Mole weight: 339.5. | |
| Ki16425 | Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA4, LPA5, LPA6. Synonyms: Ki16425; Ki-16425; Ki 16425. Grades: >98%. CAS No. 355025-24-0. Molecular formula: C23H23ClN2O5S. Mole weight: 474.96. | |
| KIN1400 | KIN1400 is an IRF3 activator with antiviral activity. It induces IRF3-dependent innate immune gene expression such as RIG-1, MDA5, IFIT1, IFIT2, IFITM1, OAS3, and Mx1 in THP-1 cells stimulated with phorbol 12-myristate 13-acetate (PMA). It also inhibits replication of HCV, West Nile virus, and Paramyxoviridae (RCV, NV). Synonyms: 7- ( (benzo[d]thiazol-2-ylamino) (4- (difluoromethoxy) phenyl) methyl) quinolin-8-ol. Grades: ≥98%. CAS No. 446826-86-4. Molecular formula: C24H17F2N3O2S. Mole weight: 449.5. | |
| KIN1408 | KIN1408 is an IRF3 activator with antiviral activity. It induces innate immune gene expression such as MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA). Synonyms: 7-[[4-(Difluoromethoxy)phenyl]-[(5-methoxy-1,3-benzothiazol-2-yl)amino]methyl]quinolin-8-ol. Grades: ≥98%. CAS No. 1903800-11-2. Molecular formula: C25H19F2N3O3S. Mole weight: 479.5. | |
| Kinetin | Kinetin is a type of cytokinin, a class of plant hormone that promotes cell division. Uses: Plant growth regulators. Synonyms: 6-Furfuryladenine; Kinetin; NSC 23119; NSC-23119; NSC23119. Grades: >98%. CAS No. 525-79-1. Molecular formula: C10H9N5O. Mole weight: 215.21. | |
| Kisspeptin-54 (human) trifluoroacetate salt | Kisspeptin-54 is an endogenous ligand for the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors respectively). It was shown to stimulate the hypothalamic-pituitary-gonadal (HPG) axis in animal models and humans. Synonyms: Metastin (human). Grades: ≥95%. Molecular formula: C258H401N79O78·xCF3COOH. Mole weight: 5857.43. | |
| KLH 45 | KLH 45 is a selective, potent and irreversible inhibitor of DDHD domain containing 2 (DDHD2) with IC50 value of 1.3 nM. It is selective for DDHD2 over 40 other serine hydrolases. It shows cross-reactivity with ABHD6. It is active in vivo and increases brain triacylglycerol levels in mouse brain. Synonyms: KLH45; KLH-45; KLH 45; N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 1632236-44-2. Molecular formula: C24H25F3N4O2. Mole weight: 458.48. | |
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