BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Ipfencarbazone | Ipfencarbazone is a non-hormonal translocation-type herbicide. It is thought to inhibit the biosynthesis of very long chain fatty acids in plants. Preparations include water-dispersible agents and compound fertilizers, and application has been made for these to be used on rice plants. Synonyms: Ipfencarbazone. Grades: >98%. CAS No. 212201-70-2. Molecular formula: C18H14Cl2F2N4O2. Mole weight: 427.23. |  |
| Ipidacrine hydrochloride hydrate | Ipidacrine is a drug used for the treatment of memory disorders. It acts as a reversible acetylcholinesterase inhibitor. Synonyms: Senita; 2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine hydrochloride hydrate. CAS No. 118499-70-0. Molecular formula: C12H16N2.HCl.H2O. Mole weight: 242.75. | |
| Ipratropium bromide monohydrate | Ipratropium bromide monohydrate is a bronchodilator used to treat chronic obstructive pulmonary disease (COPD). CAS No. 66985-17-9. Molecular formula: C20H30BrNO3·H2O. Mole weight: 430.38. | |
| IQ-R | IQ-R, a indolequinone derivative, could be used as a fluorescent probe. Uses: Iq-r could be used as a fluorescent probe. Synonyms: IQ-R; IQ R; IQR; IQ-Phodol; CS-4935; CS 4935; CS4935. Grades: 98%. CAS No. 1345445-57-9. Molecular formula: C34H28N2O7. Mole weight: 576.60. | |
| IR-825 | Cas No. 1558079-49-4. | |
| IRAK inhibitor 1 | IRAK inhibitor 1 is interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor. Synonyms: IRAK inhibitor 1; 1042224-63-4; CHEMBL258004; 6-imidazo[1,2-a]pyridin-3-yl-N-piperidin-4-ylpyridin-2-amine; 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine; 6-(Imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyridin-2-amine; irak inhibitor; CS-0603; SCHEMBL18427792; DTXSID60659159; BCP30783; EX-A3209; BDBM50240128; AKOS030526218; NCGC00379036-01; HY-13275; MS-24200; F84607; A920481; 6-(H-imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyridin-2-amine. Grades: >98%. CAS No. 1042224-63-4. Molecular formula: C17H19N5. Mole weight: 293.37. | |
| IRAK inhibitor 2 | IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor. Synonyms: Phenol, 4-[6-[(2-furanylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]-. Grades: >98%. CAS No. 928333-30-6. Molecular formula: C17H14N4O2. Mole weight: 306.32. | |
| IRAK inhibitor 3 | IRAK inhibitor 3 is interleukin-1 receptor associated kinase inhibitor. Synonyms: IRAK inhibitor 3; 1012343-93-9; 4-[[[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide; 4-(((3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)methyl)benzenesulfonamide; SCHEMBL1053021; DTXSID00648709; GLXC-25274; AKOS030526199; CS-0605; NCGC00379067-01; HY-13277; MS-27885; F84609; A921718; SR-01000377174; SR-01000377174-1; 4-({[3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino}methyl)benzene-1-sulfonamide. Grades: >98%. CAS No. 1012343-93-9. Molecular formula: C21H21N5O4S. Mole weight: 439.49. | |
| IRAK inhibitor 4 | IRAK inhibitor 4 is interleukin-1 receptor associated kinase inhibitor. Grades: >98%. CAS No. 1012104-68-5. Molecular formula: C33H35F3N6O3. Mole weight: 620.66. | |
| IRAK inhibitor 6 | IRAK inhibitor 6 is interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor. Synonyms: IRAK-IN-6; IRAK IN 6; IRAKIN6; IRAK inhibitor 6. Grades: >98%. CAS No. 1042672-97-8. Molecular formula: C20H20N4O3S. Mole weight: 396.46. | |
| Irestatin 9389 | Irestatin 9389 is a potent inhibitor of the endonuclease IRE1 (IC50 = 6.3 nM). Synonyms: AC1LJRTA; BAS 06901326; BAS06901326; BAS-06901326; 2-[[3-cyano-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide. Grades: 99%. CAS No. 626221-47-4. Molecular formula: C16H13F3N4OS2. Mole weight: 398.43. | |
| iRGD peptide | iRGD peptide is a 9-amino acid peptide and a molecular mimicry agent. It homes and penetrates tumors, increasing accumulation and penetration of anticancer drugs into tumors. Synonyms: c(CRGDKGPDC); H-Cys(1)-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys(1)-OH; L-cysteinyl-L-arginyl-glycyl-L-alpha-aspartyl-L-lysyl-glycyl-L-prolyl-L-alpha-aspartyl-L-cysteine (1->9)-disulfide; Internalized-arginylglycylaspartic acid cyclic peptide; IRGD. Grades: 98%. CAS No. 1392278-76-0. Molecular formula: C35H57N13O14S2. Mole weight: 948.04. | |
| Irinotecan 11-Desethyl Impurity | Cas No. 103816-16-6. | |
| ISA-2011B | ISA-2011B is a Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) inhibitor. Research shows that the overexpression of PIP5K1α is associated with poor prognosis in prostate cancer and correlates with an elevated level of the androgen receptor. ISA-2011B can inhibit growth of tumor cells in xenograft mice, which is mediated by targeting PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways. Uses: Anti-cancer. Synonyms: ISA2011B; ISA 2011B; ISA-2011B; ISA2011-B; ISA 2011-B; ISA-2011-B. (5S,10aS)-5-(5-chloro-1H-indol-3-yl)-9-methyl-8,9,10a,11-tetrahydro-5H-[1,3]dioxolo[4,5-g]pyrazino[1,2-b]isoquinoline-7,10-dione. Grades: 98%. CAS No. 1395347-24-6. Molecular formula: C22H18ClN3O4. Mole weight: 423.85. | |
| I-SAP | I-SAP is a high affinity TP receptor antagonist. I-SAP binds to and induces platelet shape change, but not aggregation, with EC50 value of 9.7 nM. Synonyms: Iodophenyl sulfonyl amino pinane Thromboxane A2; Iodophenyl sulfonyl amino pinane TXA2; (Z)-7-[(1S,2S,3S,5R)-3-[(4-iodophenyl)sulfonylamino]-6,6-dimethyl-2-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 133538-58-6. Molecular formula: C22H30INO4S. Mole weight: 531.4. | |
| Ischemin sodium salt | Ischemin sodium salt is the sodium form of ischemin, which is a potent CBP bromodomain inhibitor. It inhibits p53 interaction with CBP and alters post-translational modifications on p53 and histones. It decreases p53 transcriptional activity in cells. It protects against doxorubicin-induced apoptosis in ischemic cardiomyocytes in vitro. It is cell permeable. Synonyms: 5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium salt. Grades: ≥99% by HPLC. Molecular formula: C15H16N3O4SNa. Mole weight: 357.36. | |
| ISO-1 | ISO-1 is an inhibitor of the dopachrome tautomerase activity of MIF. It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis.It also demonstrates protective effects in airway and gastrointestinal inflammation in mice. Synonyms: ISO-1; ISO 1; ISO1; MIF Antagonist; Macrophage Migration Inhibitory Factor. Grades: >98%. CAS No. 478336-92-4. Molecular formula: C12H13NO4. Mole weight: 235.24. | |
| Isoastragaloside I | Isoastragaloside I is a natural compound from the medicinal herb Radix Astragali. It possesses the activity of elevating adiponectin production. It selectively increased adiponectin secretion in primary adipocytes without any obvious effects on a panel of other adipokines. Synonyms: (3beta,6alpha,16beta,20R,24S)-3-[(2,4-Di-O-acetyl-beta-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside. Grades: >98%. CAS No. 84676-88-0. Molecular formula: C45H72O16. Mole weight: 869.04. | |
| Isoastragaloside II | Isoastragaloside II is an astragaloside, which is isolated from the hairy root culture of Astragalus membranaceus. Synonyms: Astrasieversianin-VII. Grades: >98%. CAS No. 86764-11-6. Molecular formula: C43H70O15. Mole weight: 827.01. | |
| Isoastragaloside IV | Isoastragaloside IV is a chemical reference substance isolated from Astragalus membranaceus. Astragaloside is the major active constituent of Astragalus membranaceus, and in vitro studies have demonstrated that Astragaloside IV is a strong scavenger for superoxide radicals (IC50 < 0:023 mg/ml) and hydroxyl radicals (IC50 < 0:053 mg/ml). Synonyms: β-D-Glucopyranoside, (3β, ?6α, ?16β, ?20R, ?24S)?-20, ?24-epoxy-6, ?16-dihydroxy-3-(β-D-xylopyranosyloxy)?-9, ?19-cyclolanostan-25-yl. Grades:> 98%. CAS No. 136033-55-1. Molecular formula: C41H68O14. Mole weight: 784.98. | |
| Isochlorogenic acid C | Isochlorogenic acid C is extracted from the flower bud of Lonicera japonica Thunb. Isochlorogenic acid C is a selective inhibitor of human immunodeficiency virus type 1 integrase. It has antioxidant activity. Uses: Antiviral activity, including anti-hiv-1 integrase activity. Synonyms: Cyclohexanecarboxylic acid, 3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,5-dihydroxy-, (1R,3R,4S,5R)-; (1R,3R,4S,5R)-3,4-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,5-dihydroxycyclohexanecarboxylic acid; Cyclohexanecarboxylic acid, 3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,5-dihydroxy-, (1R,3R,4S,5R)-; Cyclohexanecarboxylic acid, 3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,5-dihydroxy-, [1R-(1α, 3α, 4α, 5β)]-; 4,5-Dicaffeoylquinic acid; Isochlorogenic acid c. Grades: ≥95%. CAS No. 57378-72-0. Molecular formula: C25H24O12. Mole weight: 516.45. | |
| Isocitric acid trisodium salt | Isocitric acid trisodium salt (CAS# 1637-73-6 ) is a useful research chemical. Synonyms: Sodium isocitrate; DL-Isocitric acid trisodium salt. Grades: 95 %. CAS No. 1637-73-6. Molecular formula: C6H5Na3O7. Mole weight: 258.07. | |
| (+)-Isocorynoline | Cas No. 475-67-2. | |
| (-)-Isocorypalmine | Cas No. 483-34-1. | |
| Isocyclosporin A | Cas No. 59865-16-6. | |
| Isodemethylwedelolactone | Isodemethylwedelolactone is isolated from the Eclipta prostrata. Synonyms: Isodemethylwedelolacton; 2,4,8,9-Tetrahydroxy-6H-Benzofuro[3,2-C][1]Benzopyran-6-One. Grades: >98%. CAS No. 350681-33-3. Molecular formula: C15H8O7. Mole weight: 300.22. | |
| Isofagomine | Isofagomine, an imino pyranose compound, has been found to be a glucosylceramidase stimulant and could exhibit activity in Gaucher's disease. Synonyms: (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol; Isofagomine; Iso-Fagomine. Grades: 98%. CAS No. 169105-89-9. Molecular formula: C6H13NO3. Mole weight: 147.17. | |
| Isofebrifugine | Isofebrifugine is an alkaloid with antimalarial activity. Synonyms: Isofebrifugine; 32434-44-9; CHEBI:6008IsofeBioifugine; CHEMBL105789. Grades: 98%. CAS No. 32434-44-9. Molecular formula: C16H19N3O3. Mole weight: 301.3. | |
| Isofolic acid | Cas No. 47707-78-8. | |
| Iso-H7 dihydrochloride | Iso-H7 dihydrochloride is an inhibitor of phosphokinase C. Synonyms: 1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine dihydrochloride. CAS No. 140663-38-3. Molecular formula: C14H19Cl2N3O2S. Mole weight: 364.29. | |
| Isoindigotin | Isoindigotin is a natural product found in Isatis tinctoria. Isoindigotin is an electron-accepting building block for the preparation of electroactive materials for organic electronics. Synonyms: Isoindigo; (3E)-3-(2-oxo-1H-indol-3-ylidene)-1H-indol-2-one. CAS No. 476-34-6. Molecular formula: C16H10N2O2. Mole weight: 262.26. | |
| Isokadsuranin | Isokadsuranin is a lignan isolated from the roots and stems of Kadsura coccinea. Synonyms: Schizandrin B; Wuweizisu B; Gomisin N; Deoxygomisin A. Grades: >98%. CAS No. 82467-52-5. Molecular formula: C23H28O6. Mole weight: 400.471. | |
| Isoliensinine | Isoliensinine, a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid, has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities. It possesses an anti-proliferative effect, which is related to the decrease of the overexpression of growth factors PDGF-beta, bFGF, proto-oncogene c-fos, c-myc and hsp70. Synonyms: (+)-Isoliensinin; (1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol. Grades: >98%. CAS No. 6817-41-0. Molecular formula: C37H42N2O6. Mole weight: 610.7. | |
| Isomangiferin | Isomangiferin, a natural product, has antiviral effect due to their capability of inhibiting virus replication within cells. Synonyms: (1S)-1,5-anhydro-1-(1,3,6,7-tetrahydroxy-9-oxo-9H-xanthen-4-yl)-D-glucitol;(1S)-1,5-Anhydro-1-(1,3,6,7-tetrahydroxy-9-oxo-9H-xanthen-4-yl)-D-glucitol; 9H-Xanthen-9-one, 4-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-; D-glucitol, 1,5-anhydro-1-C-(1,3,6,7-te. Grades: >98%. CAS No. 24699-16-9. Molecular formula: C19H18O11. Mole weight: 422.34. | |
| Isometamidium chloride hydrochloride | Isometamidium chloride hydrochloride is an antiprotozoal agent used in veterinary medicine. Synonyms: Samorin; Trypamidium; 3- [2- (3-amino-5-ethyl-6-phenylphenanthridin-5-ium-8-yl) iminohydrazinyl] benzenecarboximidamide chloride hydrochloride. Grades: >98%. CAS No. 6798-24-9. Molecular formula: C28H27Cl2N7. Mole weight: 532.473. | |
| Isoprenaline HCl EP Impurity A | An impurity of Isoprenaline, a medication used for the treatment of bradycardia, heart block, and rarely for asthma. Synonyms: 1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino] hydrochloride; [2-(3,4-dihydroxyphenyl)-2-oxoethyl]-propan-2-ylazanium chloride. CAS No. 16899-81-3. Molecular formula: C11H16ClNO3. Mole weight: 245.70. | |
| Isopropamide | Isopropamide is a long-acting anticholinergic drug. It can be used for the treatment of peptic ulcers and other gastrointestinal disorders including hyperacidity and hypermotility. It is often provided as an iodide salt, but is also available as a bromide or chloride salt. Uses: Peptic ulcers and other gastrointestinal disorders. Synonyms: (3-carbamoyl-3, 3-diphenylpropyl) diisopropylmethylammonium; (3-Aminocarbonyl-3, 3-diphenylpropyl) diisopropylmethylaminium; C07055. Grades: 98%. CAS No. 7492-32-2. Molecular formula: C23H33N2O. Mole weight: 353.52. | |
| Isopropyl 4-[4-[N,N-bis(2-hydroxyethyl)amino]phenyl]butyrate | Isopropyl 4-[4-[N,N-bis(2-hydroxyethyl)amino]phenyl]butyrate, a pharmaceutical intermediate, can be utilized in the production of drugs intended for the treatment of cardiovascular disease, such as hypertension. It functions as an angiotensin-converting enzyme (ACE) inhibitor, which reduces the likelihood of heart attack and stroke by regulating blood pressure levels. Consequently, it plays a valuable role in managing these serious medical conditions, thus improving overall health outcomes among patients. Synonyms: Isopropyl 4-(4-(bis(2-hydroxyethyl)amino)phenyl)butanoate. CAS No. 94086-78-9. Molecular formula: C17H27NO4. Mole weight: 309.40. | |
| Isopropylantipyrinum | Isopropylantipyrinum is a derivative of phenazone with similar analgesic and antipyretic effects. Uses: Analgesic; antipyretic; anti-inflammatory. Synonyms: Propyphenazone; 1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one; 1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one. Grades: ≥98%. CAS No. 479-92-5. Molecular formula: C14H18N2O. Mole weight: 230.31. | |
| Isopropyl-β-D-thiogalactopyranoside | IPTG is a galactose analog that is used in combination with X-GAL in cloning procedures requiring expression of β-galactosidase activity. Synonyms: IPTG; Isopropyl-beta-D-thiogalactopyranoside; Isopropyl β-D-thiogalactoside (IPTG); Isopropyl β-D-1-thiogalactopyranoside; Isopropyl 1-thio-b-D-galactopyranoside; Isopropyl 1-Thio-β-D-galactopyranoside; Isopropyl β-D-thiogalactoside; 1-Methylethyl 1-thio-beta-D-galactopyranoside. Grades: ≥98% by HPLC. CAS No. 367-93-1. Molecular formula: C9H18O5S. Mole weight: 238.30. | |
| Isopropyl ethanesulfonate | Propan-2-yl Ethane-1-sulfonate can be used as serine protease inhibitors to inhibit an increase in the blood gluocose level. Synonyms: Ethanesulfonic acid isopropyl ester; Ethanesulfonic acid, isopropyl ester. CAS No. 14245-62-6. Molecular formula: C5H12O3S. Mole weight: 152.21. | |
| Isoquercitrin | Isoquercitrin is a flavonol compound with antihypertensive, anti-depressant and sedative effects. Synonyms: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy-; 2-(3,4-Dihydroxyphenyl)-3-(β-D-glucofuranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one; Flavone, 3,3',4',5,7-pentahydroxy-, 3-β-D-glucofuranoside; Isoquercitroside; Isoquercitrozide; Isotrifoliin; Quercetin 3-(β-D-glucofuranoside); Quercetin 3-O-β-D-glucofuranoside; 3,3',4',5,7-Pentahydroxyflavone 3-β-D-Glucofuranoside. Grades: >98%. CAS No. 21637-25-2. Molecular formula: C21H20O12. Mole weight: 464.38. | |
| Isorhamnetin 3-glucoside-7-rhamnoside | Isorhamnetin 3-glucoside-7-rhamnoside is a compound of the flavonoid class found in the herbs of Hippophae rhamnoides Linn. Synonyms: Brassidin; 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one. Grades: >98%. CAS No. 17331-71-4. Molecular formula: C28H32O16. Mole weight: 624.548. | |
| Isorhamnetin-3-O-galactoside | Isorhamnetin-3-O-galactoside, an indigenous flavonoid constituent obtained through extraction from spinach and onions, has been documented to exhibit substantial antioxidative and anti-inflammatory properties, evincing prospects as a therapeutic agent in diverse ailments encompassing malignancy, diabetes, and Alzheimer's. Synonyms: Cacticin. Grades: 98%. CAS No. 6743-92-6. Molecular formula: C22H22O12. Mole weight: 478.4. | |
| Isorhamnetin 3-sophoroside-7-rhamnoside | Isorhamnetin 3-sophoroside-7-rhamnoside is a compound of the flavonoid class found in the herbs of Elaeagnus multiflora Thunb. Synonyms: 3-(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyloxy)-4',5-dihydroxy-3'-methoxy-7-(alpha-L-rhamnopyranosyloxy)flavone. Grades: >98%. CAS No. 41328-75-0. Molecular formula: C34H42O21. Mole weight: 786.689. | |
| Isorhamnetin 7-O-α-L-rhamnoside | Isorhamnetin 7-O-α-L-rhamnoside is a compound of the flavonoid class found in the herbs of Elaeagnus multiflora Thunb. Synonyms: 4H-1-Benzopyran-4-one, 7-[(6-deoxy-α-L-mannopyranosyl)oxy]-3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-. Grades: >98%. CAS No. 17331-72-5. Molecular formula: C22H22O11. Mole weight: 462.407. | |
| Isoscoparin | Isoscoparin is a compound of the flavonoid class found in the seeds of Alliaria petiolata with antioxidant activity. Isoscoparin is promisingly used in the treatment of obesity for its anti-adipogenic property. Synonyms: C-Glucosyl-6 chrysoeriol; Chrysoeriol 6-C-glucoside; Isoscoparine; (1S)-1,5-anhydro-1-[5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxo-4H-chromen-6-yl]-D-glucitol. Grades: >98%. CAS No. 20013-23-4. Molecular formula: C22H22O11. Mole weight: 462.407. | |
| Isoscoparin-2"-β-D-glucopyranoside | Isoscoparin-2"-β-D-glucopyranoside is a compound of the flavonoid class found in the seeds of Alliaria petiolata. Synonyms: Isoscoparin 2''-O-glucoside; 6-[4,5-dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one. Grades: >98%. CAS No. 97605-25-9. Molecular formula: C28H32O16. Mole weight: 624.54. | |
| Isosilybin A | Isosilybin A is a flavonoid found in Silybum marianum. Isosilybin A has been identified as the first flavonolignan PPAR-gamma agonist. Synonyms: Isosilibinin A; (+)-Isosilybin A; Silybin b2. Grades: > 95%. CAS No. 142796-21-2. Molecular formula: C25H22O10. Mole weight: 482.44. | |
| Isovaleramide | Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases. Synonyms: NPS-1776; NPS 1776; NPS1776; Isovaleramide. Grades: >98%. CAS No. 541-46-8. Molecular formula: C5H11NO. Mole weight: 101.15. | |
| Isoverticine | Isoverticine is found in Fritillaria monantha. Synonyms: Isopeimine; 6-Epiverticine; Dihydroverticinone; 17-Epidihydroimperialine. Grades: > 95%. CAS No. 23496-43-7. Molecular formula: C27H45NO3. Mole weight: 431.65. | |
| Isovitexin 2''-O-arabinoside | Isovitexin 2''-O-arabinoside is a compound of the flavonoid class found in the leaves of Secale cereale. Synonyms: 6-[4,5-dihydroxy-6-(hydroxymethyl)-3-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one. Grades: >98%. CAS No. 53382-71-1. Molecular formula: C26H28O14. Mole weight: 564.496. | |
| ISRIB | ISRIB is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Synonyms: 2- (4-chlorophenoxy) -N-[4-[[2- (4-chlorophenoxy) acetyl]amino]cyclohexyl]acetamide 2- (4-chlorophenoxy) -N- (4- (2- (4-chlorophenoxy) acetamido) cyclohexyl) acetamide ISRIB compound trans-ISRIB. CAS No. 1597403-47-8. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. | |
| ISRIB (mix-Isomer) | ISRIB (mix-Isomer), is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Synonyms: Acetamide, N,?N'-1,?4-cyclohexanediylbis[2?-(4-chlorophenoxy)?- ISRIB compound. CAS No. 548470-11-7. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. | |
| Istradefylline | Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist (Ki=2.2 nM). Uses: Adenosine a2 receptor antagonists. Synonyms: KW6002; KW 6002; KW-6002; Istradefylline. 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione. Grades: > 95%. CAS No. 155270-99-8. Molecular formula: C20H24N4O4. Mole weight: 384.43. | |
| Itacitinib | Itacitinib is a potent and selective JAK1 inhibitor developed for the treatment of Graft-versus-host disease and non-small cell lung cancer. Synonyms: INCB 039110; 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile. Grades: >98%. CAS No. 1334298-90-6. Molecular formula: C26H23F4N9O. Mole weight: 553.51. | |
| (+)-ITD-1 | (+)-ITD-1 is the (+)-enantiomer of ITD 1 that is more active. ITD-1 is a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (-)-ITD 1, respectively for TGF-β inhibition) that clears the type II TGFβ receptor from the cell surface. ITD 1 promotes the differentiation of cardiomyocytes and cardiogenesis in murine embryonic stem cell (mESCs). Synonyms: ITD-1; 1099644-42-4; ITD 1; ITD1; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate; (+)-ITD 1; 1409968-46-2; 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester; Ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate; ethyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate;6-{(1R)-1-[8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H) -one; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate. Grades: 99%. CAS No. 1409968-46-2. Molecular formula: C27H29NO3. Mole weight: 415.52. | |
| ITE | ITE is an Aryl hydrocarbon receptor ligand that acts as an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Uses: Endogenous aryl hydrocarbon receptor (ahr) agonist. Synonyms: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester. Grades: ≥98 %. CAS No. 448906-42-1. Molecular formula: C14H10N2O3S. Mole weight: 286.31. | |
| ITX3 | ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs. Synonyms: ITX 3; ITX-3. Grades: >98%. CAS No. 347323-96-0. Molecular formula: C22H17N3OS. Mole weight: 371.45. | |
| ITX-5061 | ITX-5061 is a scavenger receptor B1 antagonist. Preclinical studies show that ITX-5061 is a selective inhibitor of HCV entry into hepatocytes. It can prevent virus binding/fusion and cell to cell spread, suggesting ITX-5061 may reduce re-infection rates following liver transplant. In Jan 2015, Phase-II clinical trials in Hepatitis C in USA were on-going. Uses: Hepatitis c. Synonyms: ITX-5061; ITX 5061; ITX5061; N-(5-(tert-butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide;1252679-52-9 (HCl salt). Grades: 98%. CAS No. 848144-15-0. Molecular formula: C30H37N3O7S. Mole weight: 583.70. | |
| ITX-5061 HCl | This active molecular is a scavenger receptor B1 antagonist under the development by iTherX Pharmaceuticals for the treatment of Hepatitis C. ITX-5061 shows a special mechanism of action that prevents the hepatitis C virus from entering liver cells. Preclinical studies have shown that ITX-5061 can prevent virus binding/fusion and cell to cell spread. In Jan 2015, Phase-II clinical trials in Hepatitis C in USA was on-going. Uses: Hepatitis c. Synonyms: ITX-5061; ITX 5061; ITX5061; UNII-J4RA8K2Q2A; J4RA8K2Q2A;CHEMBL3402567;N-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide;hydrochloride;848144-15-0 (free base). Grades: 98%. CAS No. 1252679-52-9. Molecular formula: C30H38ClN3O7S. Mole weight: 620.16. | |
| IU1-47 | IU1-47 is a potent and selective inhibitor of the proteasomal deubiquitinating enzyme USP14 (IC50 = 60 nM). IU1-47 has been shown to enhance protein degradation rate in cells using as a reporter the microtubule-associated protein tau. Synonyms: 1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone. Grades: ≥98% by HPLC. CAS No. 670270-31-2. Molecular formula: C19H23ClN2O. Mole weight: 330.85. | |
| Ivospemin | Ivospemin is a spermine analogue and an antineoplastic drug. Synonyms: (6S,15S)-3,8,13,18-tetraazaicosane-6,15-diol; NSC793107; NSC-793107; 3,8,13,18-Tetraazaeicosane-6,15-diol, (6S,15S)-. CAS No. 748119-79-1. Molecular formula: C16H38N4O2. Mole weight: 318.50. | |
| IWP-051 | IWP-051 is a soluble guanylate cyclase (sGC) stimulator with EC50 of 290nM. IWP-051 shows >99% plasma protein binding, high permeability, high metabolic stability, and no efflux in a Caco-2 model of intestinal absorption. Synonyms: IWP-051; IWP051; IWP 051; 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4(3H)-one. Grades: 98%. CAS No. 1354041-91-0. Molecular formula: C17H11F2N5O2. Mole weight: 355.30. | |
| IWR-1-endo | IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Synonyms: IWR-1; IWR 1; IWR1; IWR-1-endo. Grades: >98%. CAS No. 1127442-82-3. Molecular formula: C25H19N3O3. Mole weight: 409.44. | |
| Izonsteride | Izonsteride, a benzothiazolyl derivative, has been found to be a cholestenone 5-alpha reductase inhibitor that was once studied in prostate cancer and probably be useful against androgenic alopecia and benign prostatic hyperplasia. Synonyms: Izonsteride; LY-320236; LY 320236; LY320236; UNII-A5E8C36F34.; (4AR,10BR)-8-[(4-ETHYL-1,3-BENZOTHIAZOL-2-YL)SULFANYL]-4,10B-DIMETHYL-1H,2H,3H,4H,4AH,5H,6H,10BH-BENZO[F]QUINOLIN-3-ONE. Grades: 98%. CAS No. 176975-26-1. Molecular formula: C24H26N2OS2. Mole weight: 422.62. | |
| (±)-J 113397 | (+/-)-J 113397 has been found to be a NOP receptor antagonist and could restrain nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test. Synonyms: (±)-J 113397; (±)-J113397; (±)-J-113397; (±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥98% by HPLC. CAS No. 217461-40-0. Molecular formula: C24H37N3O2. Mole weight: 399.57. | |
| JANEX-1 | A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50=78 μM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation. Synonyms: WHI-P131, WHI P-131, WHI P131, Janex 1. Grades: >98%. CAS No. 202475-60-3. Molecular formula: C16H15N3O3. Mole weight: 297.31. | |
| Jasplakinolide | Jasplakinolide acts as an actin stabilizing agent that stabilizes actin filaments and promotes actin polymerization. It is also a potent inhibitor of breast and prostrate carcinoma cell proliferation. It potently competes with phalloidin for actin binding and induces actin polymerization by stimulating actin filament nucleation in vitro. It induces polymerization of monomeric actin into amorphous masses and disrupts actin filaments in vivo. It is cell permeable and affects chromosome movement in studies. It has insecticidal, antiproliferative and fungicidal activity. It is useful for investigating cell processes mediated by actin depolymerization and polymerization. Synonyms: NSC 613009; NSC613009; NSC-613009; [2S-[1(S*),2R*,4E,6S*,8R*]]-N-[2-Bromo-N-[N-(8-hydroxy-2,4,6-trimethyl-1-oxo-4-nonenyl)-L-alanyl]-N-methyl-D-tryptophyl]-3-(4-hydroxyphenyl)-β-alanine ρ-Lactone; 1-Oxa-5,8,11-triazacyclononadecane β-alanine deriv.; (+)-Jasplakinolide; Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]. Grades: ≥97% by HPLC. CAS No. 102396-24-7. Molecular formula: C36H45BrN4O6. Mole weight: 709.67. | |
| Jatrorrhizine Hydrochloride | Jatrorrhizine Hydrochloride (JH), an active component of the traditional Chinese medicinal herb Coptis chinensis, inhibited the proliferation and neovascularization of C8161 human metastatic melanoma cells. The effective inhibitory effects of Jatrorrhizine Hydrochloride on metastatic melanoma cell proliferation and neovascularization with low toxicity suggest that Jatrorrhizine Hydrochloride is a potential new antimelanoma drug candidate. Synonyms: Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-, chloride (1:1); Berbinium, 7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxy-, chloride; Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-, monochloride; Jatrorrhizine chloride; Neprotine chloride; NSC 645313. Grades: >98%. CAS No. 6681-15-8. Molecular formula: C20H20ClNO4. Mole weight: 373.83. | |
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