BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| KLS-13019 | KLS-13019, an azetidine derivative, could be a neuroprotective agent and has been found to exbihit much more effective than cannabidiol. Synonyms: KLS-13019; KLS 13019; KLS13019; 1-(3-(((1'R,2'R)-2,6-dihydroxy-5'-methyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-4-yl)methyl)azetidin-1-yl)ethan-1-one. Grades: 98%. CAS No. 1801243-39-9. Molecular formula: C22H29NO3. Mole weight: 355.48. |  |
| KML-29 | KML-29, a effective MAGL inhibitor, has been found to have probable effect against neuropathic pain. IC50: 15, 43, and 5.9 nM (mouse, rat, and human brain proteomes). Uses: Kml-29 is a effective magl inhibitor that has been found to have probable effect against neuropathic pain. Synonyms: KML-29; KML29; KML 29; SCHEMBL15100615; SXHQLPHDBLTFPM-UHFFFAOYSA-N; BDBM179929; IN2183; ZINC97949367. Grades: 98%. CAS No. 1380424-42-9. Molecular formula: C24H21F6NO7. Mole weight: 549.42. | |
| Kobe0065 | Kobe0065 is a small-molecule Ras inhibitor that displays antitumor activity by blocking the Ras-effector interaction. Kobe0065 binds to Ras-GTP, blocking interactions with Raf kinase. Synonyms: Kobe0065; Kobe 0065; Kobe0065. CAS No. 436133-68-5. Molecular formula: C15H11ClF3N5O4S. Mole weight: 449.79. | |
| kobe2602 | Kobe2602, an analog of Kobe0065 , is a potent and selective RAS inhibitor, which exhibits inhibitory activity toward H-Ras GTP-c-Raf-1 binding both in vivo and in vitro. Synonyms: Kobe2602; Kobe 2602; Kobe-2602. CAS No. 454453-49-7. Molecular formula: C14H9F4N5O4S. Mole weight: 419.31. | |
| KPU-300 | KPU-300, a diketopiperazine derivative, has been found to be an antimicrotubule agent and exhibit cytotoxicity against HT-29 cells. IC50: 7.0 nM. Synonyms: KPU-300; KPU 300; KPU300; (E)-3-((E)-3-benzoylbenzylidene)-6-(pyridin-2-ylmethylene)piperazine-2,5-dione. Grades: 98%. CAS No. 1620692-60-5. Molecular formula: C24H17N3O3. Mole weight: 395.42. | |
| KR-32568 | KR-32568 is a sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor (IC50 = 230 nM). KR-32568 inhibited NHE-1-mediated rabbit platelet swelling induced by intracellular acidification. It reduced myocardial infarct size in an anesthetized rat model. Synonyms: [5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine. Grades: ≥98%. CAS No. 852146-73-7. Molecular formula: C13H12FN3O2. Mole weight: 261.3. | |
| K-Ras G12C-IN-1 | K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. Synonyms: K-Ras G12C-IN-1. Grades: >98%. CAS No. 1629265-17-3. Molecular formula: C22H23Cl2N3O3. Mole weight: 448.34. | |
| K-Ras G12C-IN-2 | K-Ras G12C-IN-2 is a novel and irreversible inhibitor of mutant K-ras G12C. Synonyms: K-Ras G12C-IN-2. Grades: >98%. CAS No. 1629267-75-9. Molecular formula: C21H27ClN4O3. Mole weight: 418.92. | |
| K-Ras G12C-IN-3 | K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C. Synonyms: K-Ras G12C-IN-3. Grades: >98%. CAS No. 1629268-19-4. Molecular formula: C21H19Cl3N2O3. Mole weight: 453.75. | |
| K-Ras(G12C) inhibitor 12 | K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). Synonyms: MDK-7958; MDK7958; MDK 7958; K-Ras(G12C) inhibitor 12. Grades: >98%. CAS No. 1469337-95-8. Molecular formula: C15H17ClIN3O3. Mole weight: 449.67. | |
| K-Ras-IN-1 | K-Ras-IN-1 is a K-Ras inhibitor. It binds to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. Synonyms: MDK-3017; MDK3017; MDK 3017; K-Ras-IN-2; K-Ras Inhibitor-2. 1-(2-Hydroxythiobenzoyl)pyrrolidine;6-[pyrrolidin-1-yl(sulfanyl)methylidene]cyclohexa-2,4-dien-1-one. Grades: >98%. CAS No. 84783-01-7. Molecular formula: C11H13NOS. Mole weight: 207.29. | |
| KRIBB11 | KRIBB11 is a heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. In vivo, administration of KRIBB11 decreases tumor growth in a mouse HCT116 xenograft model. Synonyms: N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine; KRIBB11; KRIBB-11; KRIBB 11. CAS No. 342639-96-7. Molecular formula: C13H12N6O2. Mole weight: 284.27. | |
| KT109 | KT109 is a selective and irreversible inhibitor of DAGLβ with an IC50 value of 42 nM. Inhibition of DAGLβ by KT109 reduced the LPS-induced allodynia in the LPS model of inflammatory pain. Synonyms: (4-([1,1'-Biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-benzylpiperidin-1-yl)methanone. Grades: ≥98%. CAS No. 1402612-55-8. Molecular formula: C27H26N4O. Mole weight: 422.5. | |
| KT182 | KT182 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6). ABHD6 is a transmembrane serine hydrolase hydrolyzing transmembrane serine hydrolase in nernous system. ABHD6 inhibition was shown to decrease seizure incidence in several mouse models of epilepsy, suggesting its potential for Dravet Syndrome treatment. Uses: Enzyme inhibitors. Synonyms: [4-[4-[3-(hydroxymethyl)phenyl]phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone. Grades: ≥98%. CAS No. 1402612-62-7. Molecular formula: C27H26N4O2. Mole weight: 438.5. | |
| KT195 | KT195 is a selective inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6) (IC50 = 10 nM). ABHD6 is a transmembrane serine hydrolase hydrolyzing transmembrane serine hydrolase in nernous system. ABHD6 inhibition was shown to decrease seizure incidence in several mouse models of epilepsy, suggesting its potential for Dravet Syndrome treatment. Synonyms: ML-295; (4-(4'-Methoxy-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone. Grades: ≥98%. CAS No. 1402612-58-1. Molecular formula: C27H26N4O2. Mole weight: 438.5. | |
| KT203 | KT203 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6). ABHD6 is a transmembrane serine hydrolase hydrolyzing transmembrane serine hydrolase in nervous system. ABHD6 inhibition was shown to decrease seizure incidence in several mouse models of epilepsy, suggesting its potential for Dravet Syndrome treatment. Synonyms: ML-296; 3-[4-[1-(2-Benzylpiperidine-1-carbonyl)triazol-4-yl]phenyl]benzoic acid. Grades: ≥95%. CAS No. 1402612-64-9. Molecular formula: C28H26N4O3. Mole weight: 466.5. | |
| KT 5926 | KT 5926, an organic heterooctacyclic compound, selectively inhibits nerve growth factor-dependent neurite elongation. Uses: Enzyme inhibitors. Synonyms: 9-hydroxy-9-methoxycarbonyl-8-methyl-14-n-propoxy-2, 3, 9, 10-tetrahydro-8, 11-epoxy-1H, 8H, 11H-2, 7b, 11a-triazadibenzo(a, g)cycloocta[cde]trinden-1-on; KT5926; KT-5926; KT 5926. CAS No. 126643-38-7. Molecular formula: C30H27N3O6. Mole weight: 525.55. | |
| Ku-0063794 | KU-0063794 is an inhibitor of both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. KU-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. It also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). It does not affect Thr308 phosphorylation in fibroblasts lacking essential mTORC2 subunits. KU-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. KU-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated. Uses: Differentiation. Synonyms: KU0063794; KU-0063794; KU 0063794; Ku0063794; Ku 0063794; Ku-0063794; KU63794; KU 63794; KU-63794; [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol. Grades: 0.98. CAS No. 938440-64-3. Molecular formula: C25H31N5O4. Mole weight: 465.554. | |
| KU-60019 | KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells. Synonyms: KU60019; KU 60019; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide. Grades: 98%. CAS No. 925701-49-1. Molecular formula: C30H33N3O5S. Mole weight: 547.67. | |
| Kuromanin chloride | Kuromanin chloride is a natural compound found in Amelanchier spicata, Acer paxii. It is a scavenger of peroxynitrite and that exert a protective effect against endothelial dysfunction and vascular failure induced by peroxynitrite. Uses: Antioxidative. Synonyms: Kuromanine; Chrysontemin; Cyanidin-3-glucoside chloride. Grades: >98%. CAS No. 7084-24-4. Molecular formula: C21H21O11 Cl. Mole weight: 484.85. | |
| Kushenol I | Kushenol I is a compound of the flavonoid class found in the Sophora flavescens Ait. Kushenol I is a GABAA receptor modulator and a Sodium-dependent glucose cotransporter 2(SGLT2) inhibitor. Synonyms: NSC 668937. Grades: >98%. CAS No. 99119-69-4. Molecular formula: C26H30O7. Mole weight: 454.5. | |
| KuWal151 | KuWal151 is a potent and selective CLK inhibitor with IC50 values of 28, 88 and 510 nM for CLK4, 1 and 2, respectively. It inhibits growth of a range of cancer cell lines at subnanomolar concentrations. Synonyms: 3-(3-Chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one. Grades: ≥98% by HPLC. CAS No. 2341841-06-1. Molecular formula: C16H11ClN2O. Mole weight: 282.72. | |
| KY 05009 | KY 05009 is an inhibitor of Traf2- and Nck-Interacting Kinase (TNIK; Ki value 100 nM in ATP competitive assay) that attenuates TGF-β1-mediated Wnt and Smad signaling and epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma A549 cells. In addition, KY05009 inhibits TGF-β1-induced phosphorylation of JNK1/2, FAK, Src, and paxillin. Synonyms: KY 05009; KY05009; KY-05009; 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide; 2-anilino-5-[(4-methylbenzoyl)amino]-1,3-thiazole-4-carboxamide. Grades: 99%. CAS No. 1228280-29-2. Molecular formula: C18H16N4O2S. Mole weight: 352.41. | |
| KY-1044 | KY-1044 is a novel anti-inducible co-stimulator molecule (ICOS) subclass G1 kappa monoclonal antibody developed for the treatment of cancer. KY-1044 has a dual mechanism of action: stimulating immune cells which are fighting the tumor, while also killing a type of cell known as T regulatory cells (Tregs). Uses: Potential cancer therapy. Synonyms: KY-1044; KY1044; KY1044. | |
| Kynurenic acid sodium salt | Kynurenic acid sodium salt is the sodium form of kynurenic acid, which is a broad spectrum EAA antagonist. Synonyms: 4-Hydroxyquinoline-2-carboxylic acid sodium salt. Grades: ≥99% by HPLC. CAS No. 2439-2-3. Molecular formula: C10H6NNaO3. Mole weight: 211.15. | |
| KYP-2047 | KYP-2047 is a selective Prolyl oligopeptidase inhibitor. And it is also known as prolyl endopeptidase. KYP-2047 can reduce α-synuclein protein levels and aggregate in cellular and animal models of Parkinson's disease. KYP-2047 can clear the α-synuclein aggregates induced by oxidative stress in the neuronal cells. Uses: Parkinson's disease. Synonyms: KYP-2047; KYP2047; KYP 2047. (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile. Grades: 95%. CAS No. 796874-99-2. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| L-161,982 | L-161,982 is a selective and potent EP4 receptor antagonist with Ki value of 0.024 μM. It is selective over all other members of the prostanoid receptor family with Ki values of 19, 23 and 1.90μM for human EP1, EP2 and EP3 receptors respectively. It suppresses PGE2-induced bone formation in young rats at 10 mg/kg/day and prevents the nociceptive response induced by misoprostol in formalin-injected mice. It reverses the anti-inflammatory action of PGE2 in LPS-activated human macrophages at 100 nM. It blocks PGE2-induced cell proliferation in HCA-7 colon cancer cells at 10 μM. Synonyms: L-161,982; L 161,982; L161,982; N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide. Grades: ≥99% by HPLC. CAS No. 147776-06-5. Molecular formula: C32H29F3N4O4S2. Mole weight: 654.72. | |
| L-368,899 hydrochloride | L-368,899 hydrochloride is the hydrochloride salt of L-368,899, which is a non-peptide, orally active and potent oxytocin receptor antagonist with IC50 value of 8.9 nM. It displays > 40-fold selectivity over vasopressin V1a and V2 receptors. It antagonizes oxytocin-induced uterine contractions in vitro and in vivo. It may be used in the treatment of early pregnancy failure. Synonyms: L-368,899 hydrochloride; L 368,899 hydrochloride; L368,899 hydrochloride; L368899 hydrochloride; (2S) -2-Amino-N- [ (1S, 2S, 4R) -7, 7-dimethyl-1- [ [ [4- (2-methylphenyl) -1-piperazinyl]sulfonyl]methyl]bicyclo [2. 2. 1]hept-2-yl]-4- (methylsulfonyl) butanamide; 1- ( (7, 7-Dimethyl-2 (S) - (2 (S) -amino-4- (methylsulfonyl) butyramido) bicyclo[2, 2, 1]heptan-1 (S) -yl) methylsulfonyl) -4- (2-methylphenyl) piperazine hydrochloride. Grades: ≥97% by HPLC. CAS No. 160312-62-9. Molecular formula: C26H43N4O5S2Cl. Mole weight: 591.23. | |
| L-371,257 | L-371,257 is a potent and high affinity human oxytocin (OT) receptor antagonist with Ki value of 4.6 nM. It displays > 800-fold selectivity over human arginine vasopressin receptors V1a and V2. It antagonizes oxytocin-induced contractionsin in anesthetised rats following intravenous and intraduodenal administration. It also inhibits oxytocin-induced contractionsin in isolated rat uterine tissue. It decreases length of U-87MG cell projections induced by retinoic acid. It is orally active. Synonyms: L-371,257; L 371,257; L371,257; 1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one; 1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine. Grades: ≥99% by HPLC. CAS No. 162042-44-6. Molecular formula: C28H33N3O6. Mole weight: 507.59. | |
| L-655,240 | L-655,240 is a potent and selective antagonist of thromboxane and prostaglandin endoperoxide receptor. It also blocks TP-mediated bronchoconstriction in vivo and platelet aggregation ex vivo. Synonyms: 3-(1-(4-Chlorobenzyl)-5-fluoro-3-methylindol-2-yl)-2,2-dimethylpropanoic acid. Grades: ≥98%. CAS No. 103253-15-2. Molecular formula: C21H21ClFNO2. Mole weight: 373.9. | |
| L-670,596 | L-670,596 is a potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist with IC50 value of 5.5 nM. It displays ALDH1A1 specific inhibitory activity. It inhibits human platelet aggregation and U-44069-induced contractions of guinea pig trachea in vitro. It also inhibits thromboxane-mediated endothelial cell death. It is orally active in vivo. Synonyms: L-670596; L 670596; L670596; (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid; 2-[6,8-Difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid. Grades: ≥98% by HPLC. CAS No. 121083-05-4. Molecular formula: C22H21F2NO4S. Mole weight: 433.47. | |
| L-685,458 | L-685,458 is a potent and selective inhibitor of γ-secretase (IC50 = 17 nM) that shows 50-fold selectivity over a variety of aspartyl proteases. It also inhibits Aβ40 and Aβ42 peptides (in human neuroblastoma cells: IC50=48 and 67 nM respectively). Uses: Gamma secretase inhibitors and modulators. Synonyms: L-685458; tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate. Grades: >98%. CAS No. 292632-98-5. Molecular formula: C39H52N4O6. Mole weight: 672.85. | |
| L-689502 | A potent inhibitor of HIV-l protease (IC50= 1 nM). Synonyms: L 689502; L-689502; L689502; L-689,502; L 689,502; L689,502; tert-butyl N-[(2S,3S,5R)-3-hydroxy-6-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-[[4-(2-morpholin-4-ylethoxy)phenyl]methyl]-6-oxo-1-phenylhexan-2-yl]carbamate; L 689502; L-689,502. Grades: ≥98% (HPLC). CAS No. 138483-63-3. Molecular formula: C39H51N3O7. Mole weight: 673.84. | |
| L-690,330 | L-690,330 is a potent inositol monophophatase (IMPase) inhibitor in vitro and in vivo. It induces autophagy in COS-7 cells independently of mTOR inhibition. It is stable to hydrolysis. Synonyms: L690330; L 690330; L-690330. [1- (4-Hydroxyphenoxy) ethylidene]bisphosphonic Acid; P, P'-[1- (4-Hydroxyphenoxy) ethylidene]bis[phosphonic acid]; L 690330. CAS No. 142523-38-4. Molecular formula: C8H12O8P2. Mole weight: 298.13. | |
| L-690,488 | L-690,488 is a cell-permeable prodrug of the L-690,330, which is a potent bisphosphonate inositol monophophatase inhibitor. It penetrates cells more effectively than its metabolite. Synonyms: L-690,488; L 690,488; L690488; L 690488; 1-[ (4-Hydroxyphenoxy) ethylidene]bis[phosphinylidynebis (oxymethylene) ]-2, 2-dimethylpropanoate. Grades: ≥98% by HPLC. CAS No. 142523-14-6. Molecular formula: C32H52O16P2. Mole weight: 754.70. | |
| L-798,106 | L-798,106 is a potent and highly selective prostanoid receptor EP3 antagonist wth Ki value of 0.3 nM. It is used in prostanoid receptor signaling studies that regulates the central excitatory effects of PGE(2) and COX-2 levels on PVN neurons. It has been used to tease out EP3 agonist activity both in vitro and in vivo. It successfully blocks the EP3 agonist activity of sulprostone on guinea pig vas deferens and trachea at 0.2 μM. It attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo. Synonyms: L-798,106; L 798,106; L798,106. N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide; L-798106; (2E)-N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide; CM 9; GW 671021; (E)-N-(5-bromo-2-methoxyphenyl)sulfonyl-3-[2-(naphthalen-2-ylmethyl)phenyl]prop-2-enamide. Grades: ≥99% by HPLC. CAS No. 244101-02-8. Molecular formula: C27H22BrNO4S. Mole weight: 536.44. | |
| L-869298 | L-869298 is a high potent and selective PDE4 inhibitor, acts as a Type 4 cyclic nucleotide phosphodiesterase inhibitor. Uses: Type 4 cyclic nucleotide phosphodiesterase inhibitor. Synonyms: L-869298; L-869298; L-869298; (S)-L-869298. 2-Thiazolemethanol, 5-((1S)-1-(3-(cyclopropyloxy)-4-(difluoromethoxy)phenyl)-2-(1-oxido-3-pyridinyl)ethyl)-alpha,alpha-bis(trifluoromethyl)-. Grades: ≥98%. CAS No. 362718-73-8. Molecular formula: C23H18F8N2O4S. Mole weight: 570.45. | |
| Lactisole sodium | Lactisole is a sweet taste receptor antagonist that suppresses perception of sweetness in humans. It blocks a heterodimeric receptor comprised of T1R2+T1R3, which detects sweet-tasting compounds. Synonyms: na-PMP; Sodium 2-(4-methoxyphenoxy)propanoate. Grades: ≥98%. CAS No. 150436-68-3. Molecular formula: C10H11O4·Na. Mole weight: 218.18. | |
| Lactosylsphingosine | Lactosylsphingosine, a sphingolipid, is a vital biomarker characterizing diverse lysosomal storage disorders such as Niemann-Pick disease and Gaucher disease due to its accumulation within the tissues and blood of affected people. Detection through blood examination or imaging studies makes identification possible. Therapy options include substrate reduction and enzyme replacement therapy. Furthermore, tracking variations in lactosylsphingosine may be employed to monitor therapy response and trace disease advancement, imparting substantial clinical value in disease management. Synonyms: D-lactosyl-beta1-1'-D-erythro-sphingosine; Lactosyl(beta) Sphingosine (d18:1); 2S,3R1-beta-lactosyl-sphing-4-enine; lyso-Lactosylceramide; 1-b-Lactosyl-sphing-4-enine; lyso-LC. Grades: >99%. CAS No. 109785-20-8. Molecular formula: C30H57NO12. Mole weight: 623.77. | |
| Ladarixin | Ladarixin is Interleukin 8A and Interleukin 8B receptor antagonist. IL-8A and IL-8B inhibition blocks and reverses type 1 diabetes in mice. In Dec 2015, Phase-II clinical trials in Type-1 diabetes mellitus in Italy were on-going. Uses: Type 1 diabetes mellitus. Synonyms: 4-((2R)-1-Oxo-1-(methanesulfonamido)propan-2-yl)phenyl trifluoromethanesulfonate;865625-56-5(sodium). Grades: 98%. CAS No. 849776-05-2. Molecular formula: C11H12F3NO6S2. Mole weight: 375.33. | |
| Lalistat 1 | Lalistat 1 is a lysosomal acid lipase inhibitor with IC50 value of 68 nM. It can block LAL-mediated lipid hydrolysis of acetylated LDL and reduce efflux of cholesterol from lipid-loaded cells. Synonyms: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate. Grades: ≥98% by HPLC. CAS No. 501104-16-1. Molecular formula: C12H18N4O3S. Mole weight: 298.36. | |
| Lalistat 2 | Lalistat 2 is a lysosomal acid lipase inhibitor with IC50 value of 152 nM. Lalistat-2 can affect lipid droplets morphology and localization. Synonyms: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate. Grades: ≥98% by HPLC. CAS No. 1234569-09-5. Molecular formula: C13H20N4O2S. Mole weight: 296.39. | |
| (+)-L-Alliin | (+)-L-Alliin is a precursor to Allicin, a cysteine sulfoxide constituent of garlic. Allicin exhibits antibacterial and antioxidant activity. Synonyms: 3-(Allylsulfinyl)alanine; (S)-L-3-(Allylsulfinyl)-alanine; (S)-3-(2-propenylsulfinyl)-L-Alanine; 3-[(S)-2-Propenylsulfinyl]-L-alanine; Alliin; S-Allyl-L-cysteine-(+)-sulfoxide; L-Cysteine, S-2-propen-1-yl-, S-oxide, [S(S)]-; L-Alanine, 3-(2-propenylsulfinyl)-, (S)-; L-Alanine, 3-[(S)-2-propenylsulfinyl]-; Alanine, 3-(allylsulfinyl)-, (S)-L-. Grades: 98%. CAS No. 556-27-4. Molecular formula: C6H11NO3S. Mole weight: 177.22. | |
| L-α-Aspartyl-D-phenylalanine methyl ester | L-α-Aspartyl-D-phenylalanine methyl ester, a dipeptide compound, bears promise in the biomedical sector for its potential inhibitory impact on angiotensin converting enzyme (ACE), thus potentially reducing blood pressure levels. It has also shown potential in the treatment of hypertensive, cardiac failure, and other cardiovascular conditions. The study of its properties continues to generate interest and attention from academia and the scientific community. Synonyms: L-alpha-Aspartyl-D-phenylalanine methyl ester. CAS No. 22839-65-2. Molecular formula: C14H18N2O5. Mole weight: 294.3. | |
| Lamivudine Impurity G | A metabolite of Lamivudine, an antiviral that inhibits HIV-reverse transcriptase. Synonyms: Lamivudine (S)-Sulfoxide; Lamivudine S-Oxide; 4-Amino-1-[(2R,3S,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; [2R-(2α,3α,5α)]-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone S-Oxide; 1,3-Oxathiolane, 2(1H)-pyrimidinone Deriv.; Lamivudine sulfoxide. Grades: > 95%. CAS No. 160552-55-6. Molecular formula: C8H11N3O4S. Mole weight: 245.26. | |
| Lamotrigine isethionate | Lamotrigine isethionate can inhibit glutamate release. It also shows anticonvulsant effects. It is an antiepileptic. Synonyms: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine isethionate. Grades: ≥99% by HPLC. CAS No. 113170-86-8. Molecular formula: C9H7Cl2N5.C2H6O4S. Mole weight: 382.22. | |
| Lanabecestat | Lanabecestat, also referred to AZD3293, is an orally active and highly permeable potent inhibitor of human β-secretase 1 in clinical development for the treatment of Alzheimer disease with a Ki of 0.4 nM. Synonyms: (1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine; 4-methoxy-5'-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro(cyclohexane-1,2'-inden-1',2'-imidazol)-4'-amine; AZD3293; AZD 3293; AZD-3293. CAS No. 1383982-64-6. Molecular formula: C26H28N4O. Mole weight: 412.53. | |
| Lanopepden | This active molecular is a selective peptide deformylase inhibitor. It has good anti-bacteria activity in vitro. Antibacterial spectrum of Lanopepden includes S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. It can also used to the treatment of infectious diseases caused by drug-resistant pathogens. In Jan 1st 2015, GlaxoSmithKline withdrew phase I trial in Bacterial infections in USA. In 26th Jan 2015,GlaxoSmithKline withdrew a phase I pharmacokinetics/pharmacodynamics trial in Healthy volunteers in USA. Uses: The treatment of infectious diseases caused by drug-resistant pathogens. Synonyms: N-[(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro- 6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]- 2-methylpyrimidin-4-yl}hydrazin-1-yl)-3-oxopropyl]- N-hydroxyformamide,GSK-1322322,GSK-322. Grades: 98%. CAS No. 1152107-25-9. Molecular formula: C22H34FN7O4. Mole weight: 479.58. | |
| Lansoprazole EP Impurity A | An impurity of Lansoprazole. Synonyms: 2-[[[3-Methyl-1-oxido-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole; Lansoprazole N-Oxide. Grades: > 95%. CAS No. 213476-12-1. Molecular formula: C16H14F3N3O3S. Mole weight: 385.37. | |
| Lansoprazole EP Impurity B (Lansoprazole Sulfone) | A metabolite of Lansoprazole, as gastric pump inhibitor. Synonyms: 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole; AG 1813. Grades: > 95%. CAS No. 131926-99-3. Molecular formula: C16H14F3N3O3S. Mole weight: 385.37. | |
| Lansoprazole Related Compound 3 | Lansoprazole impurity. Synonyms: N-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl Lansoprazole Sulfide; 1-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazole. Grades: > 95%. CAS No. 1083100-27-9. Molecular formula: C25H22F6N4O2S. Mole weight: 556.53. | |
| Lansoprazole sodium | Lansoprazole sodium is the sodium salt form of Lansoprazole. Lansoprazole, a substituted benzimidizole, is proton pump inhibitor, is a proton pump inhibitor which prevents the stomach from producing acid. Synonyms: 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]benzimidazol-1-ide 2- ( ( (3-Methyl-4- (2, 2, 2-trifluoroethoxy) -2-pyridyl) methyl) sulfinyl) benzimidazole Abbot Brand of Lansoprazole AG 1749 AG-1749 AG1749 Agopton Almirall Brand of Lansoprazole. CAS No. 226904-00-3. Molecular formula: C16H13F3N3NaO2S. Mole weight: 391.34. | |
| Lansoprazole Thioxo Impurity | Lansoprazole impurity. Synonyms: 1-Methyl-12-thioxopyrido[1,2,3,4]imidazole-[1,2-a]benzimidazole-2(12H)-one. Grades: > 95%. CAS No. 1246819-06-6. Molecular formula: C14H9N3OS. Mole weight: 267.31. | |
| LAP | LAP is a cytocompatible, water soluble, Type I photoinitiator. It is used in the polymerization of hydrogels or other polymeric materials, specifically in the photopolymerization of PEG-diacrylate. It is preferred over irgacure 2959 for biological applications because of its increased polymerization rates with 365 nm light and absorbance at 400 nm, which allows for polymerization with visible light. It enables cell encapsualation at reduced initiator concentration and longer wavelength light, which has been proved to reduce initiator toxicity and increase cell viability. Synonyms: P-Phenyl-P-(2,4,6-trimethylbenzoyl)phosphinic Acid; Phenyl(2,4,6-trimethylbenzoyl)-phosphinic Acid Lithium Salt; Lithium Phenyl-2,4,6-trimethylbenzoylphosphinate; Lithium PTMB phosphinate. Grades: ≥98% by HPLC. CAS No. 85073-19-4. Molecular formula: C16H16LiO3P. Mole weight: 294.21. | |
| L-AP6 | L-AP6 is a selective agonist for 'quis'-sensitized site. Synonyms: L-AP6; L AP6; LAP6; L-(+)-2-Amino-6-phosphonohexanoic acid; 6-Phosphononorleucine. Grades: ≥95% by HPLC. CAS No. 78944-89-5. Molecular formula: C6H14NO5P. Mole weight: 211.15. | |
| Lapaquistat acetate | Lapaquistat acetate, also referred as TAK475, is a squalene synthase inhibitor. As a cholesterol-lowering drug, Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Uses: A novel squalene synthase inhibitor. Synonyms: 2-[1-[2-[(3R,5S)-1-(3-acetyloxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acid; (1-(2-(1-(2-carboxyoxy-1,1-dimethylethyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo(e)(1,4)oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid; 1-((1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid; lapaquistat; TAK 475; TAK-475; TAK475. Grades: >98%. CAS No. 189060-13-7. Molecular formula: C33H41ClN2O9. Mole weight: 645.14. | |
| Lappaconitine | Lappaconitine, extracted form the roots of Aconitum carmichaeli Debx, has neurotoxic, cardiotoxic and strong analgesic activities that does not involve the opioid receptor, and further suggest that the central nervous system may be involved in the action. Synonyms: (+)-Lappacontine; Acetyl-10-deoxysepaconitine; Aconitane-4,8,9-triol, 20-ethyl-1,14,16-trimethoxy-, 4-(2-acetylamino)benzoate), (1-alpha,14-alpha,16-beta)-. Grades: >98%. CAS No. 32854-75-4. Molecular formula: C32H44N2O8. Mole weight: 584.70. | |
| Laquinimod | Laquinimod, also known as, is an experimental immunomodulator developed by Active Biotech and Teva. It is being investigated as an oral treatment for multiple sclerosis (MS). Laquinimod is the successor of Active Biotech's failed experimental immunomodulator linomide. Laquinimod seems to be able to reduce the MS disease activity on MRI. In 2011, Teva announced its clinical trials involving laquinimod had failed, being unable to significantly reduce relapses into MS among patients beyond a placebo. However, the final results of above-mentioned phase III trial proved oral laquinimod administered once daily slowed the progression of disability and reduced the rate of relapse in patients with relapsing-remitting multiple sclerosis. Synonyms: Laquinimod; ABR 215062; ABR215062; ABR-215062. ABR-215062; SAIK-MS; TV-5600; TV5600; TV 5600. CAS No. 248281-84-7. Molecular formula: C19H17ClN2O3. Mole weight: 356.8. | |
| L-Arginine α-ketoglutarate | L-Arginine α-ketoglutarate is a salt form of arginine, which is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. Protein supplement in health care products. Uses: Ingredient of health care products. Synonyms: Arginine oxoglurate; L-Arginine alpha-Ketoglutarate(1:1); (S)-2-Amino-5-guanidinopentanoic acid 2-oxopentanedioic acid (1:1); L-Arginine alpha-ketoglutarate. Grades: 95%. CAS No. 16856-18-1. Molecular formula: C11H20N4O7. Mole weight: 320.302. | |
| Larotaxel | Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier. Synonyms: XRP9881; PNU 100940. CAS No. 156294-36-9. Molecular formula: C45H53NO14. Mole weight: 831.912. | |
| Lathosterol | Lathosterol is an intermediate in the biosynthesis of cholesterol. Lathosterol in serum is carried on lipoproteins and is indicative of the rate of cholesterol synthesis. It acts as a marker of synthesis of cholesterol and is not affected by dietary consumption of cholesterol. Synonyms: 5alpha-Cholest-7-en-3beta-ol; Cholest-7-en-3-ol; 7-Cholesten-3-beta-ol. Grades: >99%. CAS No. 80-99-9. Molecular formula: C27H46O. Mole weight: 386.65. | |
| Latrunculin A | Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges. It is a disruptor of microfilament-mediated processes. It is also an actin assembly and polymerization inhibitor. Synonyms: Latrunculin A; Latrunculin-A; 4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone. Grades: ≥98% by HPLC. CAS No. 76343-93-6. Molecular formula: C22H31NO5S. Mole weight: 421.55. | |
| Latrunculin B | Latrunculin B is a marine toxin which acts as an inhibitor of actin polymerization. It causes concentration-dependent changes in cell shape and actin organization. Synonyms: Latrunculin B; LAT-B; LATB; LAT B; NSC 339663; NSC-339663; NSC339663; (4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone. Grades: ≥97% by HPLC. CAS No. 76343-94-7. Molecular formula: C20H29NO5S. Mole weight: 395.51. | |
| Laulimalide | Laulimalide is a microtubule stabilizer that can inhibit cellular proliferation in cancer cell lines. Synonyms: Fijianolide B; (1R,3S,7S,8S,10S,12S,15Z,18R)-12-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propen-1-yl]-7-hydroxy-3-methyl-5-methylene-9,13,22-trioxatricyclo[16.3.1.08,10]docosa-15,19-dien-14-one. Grades: ≥97% by HPLC. CAS No. 115268-43-4. Molecular formula: C30H42O7. Mole weight: 514.65. | |
| (±)-Lauroylcarnitine chloride | (±)-Lauroylcarnitine chloride is an acylcarnitine used to improve in vivo absorption of certain hydrophilic compounds. Synonyms: (3-Carboxy-2-hydroxypropyl)trimethylammonium Chloride Laurate; 3-Carboxy-N,N,N-trimethyl-2-[(1-oxododecyl)oxy]-1-propanaminium Chloride; (3-Carboxy-2-hydroxypropyl)trimethylammonium Chloride Laurate (Ester); 3-Carboxy-2-(dodecanoyloxy)-N,N,N-trimethylpropan-1-aminium Chloride. Grades: ≥98% by HPLC. CAS No. 14919-37-0. Molecular formula: C19H38NO4Cl. Mole weight: 379.97. | |
| Lauryl-LF 11 | Lauryl-LF 11 shows enhanced antibacterial and LPS-binding activities. Synonyms: Lauryl-LF 11; Lauryl-LF11; L-Argininamide,N-(1-oxododecyl)-L-phenylalanyl-L-glutaminyl-L-tryptophyl-L-glutaminyl-L-arginyl-L-asparaginyl-L-isoleucyl-L-arginyl-L-lysyl-L-valyl-; AKOS024458154; PD079672. Grades: 96%. CAS No. 832729-14-3. Molecular formula: C81H134N26O15. Mole weight: 1712.11. | |
| Lavamilast | Lavamilast is bio-active molecular as a PDE4 inhibitor but no detailed data has been published yet. Synonyms: 4-((3,5-dichloropyridin-4-yl)amino)-7-methoxy-8-((6-morpholinohexyl)oxy)quinolin-2(1H)-one. Grades: 98%. CAS No. 1218778-89-2. Molecular formula: C25H30Cl2N4O4. Mole weight: 521.44. | |
| Lavendustin B | Lavendustin B is a competitive inhibitor of glucose transporter 1 (Glut1), and also an inhibitor of the interaction between HIV-1 integrase and LEDGF/p75. It can be used as a negative control of Lavendustin A. Synonyms: 5-[bis[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid. Grades: ≥95%. CAS No. 125697-91-8. Molecular formula: C21H19NO5. Mole weight: 365.38. | |
| Lazabemide hydrochloride | Lazabemide is a monoamine oxidase B inhibitor with IC50 values of 0.03 and > 100 μM for MAO-B and MAO-A. It is potentially an antiparkinsonian agent. Uses: Antiparkinson agents. Synonyms: N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 103878-83-7. Molecular formula: C8H10ClN3O.HCl. Mole weight: 236.1. | |
| LB-100 (1R,4S) | Cas No. 1632032-53-1. | |
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