BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| MI-2 (MALT1 inhibitor) | MI-2 (350 mg/kg) is nontoxic to mice. MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM. Synonyms: MI-2; MI 2; MI2. Grades: >98%. CAS No. 1047953-91-2. Molecular formula: C19H17Cl3N4O3. Mole weight: 455.72. |  |
| MI-538 | MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Lineage Leukemia) inhibitor, demonstrated a pronounced effect in a mouse model of MLL leukemia. In vitro inhibition of the menin-MLL interaction with IC50=21 nM, and the binding affinity to menin (Kd = 6.5 nM). Synonyms: MI-538; MI 538; MI538. 1-((1H-pyrazol-4-yl)methyl)-6-hydroxy-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile. Grades: >98%. CAS No. 1857417-10-7. Molecular formula: C27H25F3N8OS. Mole weight: 566.607. | |
| MIBG hemisulfate | MIBG hemisulfate is a radiopharmaceutical used in a scintigraphy method called MIBG scan. It demethylates and oxidizes membrane-associated DNA for the treatment of certain kinds of cancer of the adrenal glands. Uses: Antitumor agent. Synonyms: Iobenguane sulfate; M-Iodobenzylguanidine hemisulfate; 3-Iodobenzyl-guanidine hemisulfate; 3-Iodobenzylguanidine hemisulfate; 2-[(3-iodophenyl)methyl]guanidine sulfuric acid. Grades: 99%. CAS No. 87862-25-7. Molecular formula: C16H22I2N6O4S. Mole weight: 648.3. | |
| Micheliolide | Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs). Grades: >98%. CAS No. 68370-47-8. Molecular formula: C15H20O3. Mole weight: 248.32. | |
| midodrine hydrochloride | A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects. Synonyms: Midodrine HCl; Pro-Amatine. Grades: 95%. CAS No. 3092-17-9. Molecular formula: C12H18N2O4.HCl. Mole weight: 290.75. | |
| Miglustat HCl | Miglustat HCl is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1). It also inhibits glucosidase I and II, as well as HIV-1 and HIV-2 infection of peripheral blood mononuclear cells (PBMCs). Synonyms: Miglustat hydrochloride. Grades: 98%. CAS No. 210110-90-0. Molecular formula: C10H21NO4 HCl. Mole weight: 255.74. | |
| Milrinone | Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with vasodilator properties, used to increase the heart's contractility. It increases erythrocyte cAMP activity via inhibiting erythrocyte phosphodiesterase. Uses: Increase the heart's contractility. Synonyms: Primacor; Corotrope; Corotrop; Milrinona. Grades: >98%. CAS No. 78415-72-2. Molecular formula: C12H9N3O. Mole weight: 211.22. | |
| MI-nc hydrochloride | MI-nc is a weak inhibitor of the menin-MLL fusion protein interaction (IC50 = 193 μM). Menin is a protein encoded by the MEN1 gene, which is mutated in patients with multiple endocrine neoplasia type 1 (MEN1) syndrome. Synonyms: 6-ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]-thieno[2,3-d]pyrimidine dihydrochloride. Grades: ≥98%. CAS No. 1934302-23-4. Molecular formula: C14H16N6S2·2HCl. Mole weight: 405.4. | |
| m-Iodobenzylguanidine | m-Iodobenzylguanidine is an inhibitor of arginine specific mono-ADP-ribosyltransferase. Uses: Antineoplastic agents. Synonyms: MIBG. CAS No. 80663-95-2. Molecular formula: C8H10IN3. Mole weight: 275.09. | |
| MIR96-IN-1 | MIR96-IN-1, a benzimidazole derivative, could restrain microRNA-96 biogenesis and also be probable to lead to the apoptosis of cancer cells. Uses: Mir96-in-1 could restrain microrna-96 biogenesis and also be probable to lead to the apoptosis of cancer cells. Synonyms: MIR96-IN-1; MIR96 IN 1; MIR96IN1; MIR96 inhibitor 1; MIR96-inhibitor-1; SCHEMBL16451136; CS-5422; HY-15843; CS 5422; HY 15843; CS5422; HY15843. Grades: 98%. CAS No. 1311982-88-3. Molecular formula: C33H48N8O2. Mole weight: 588.79. | |
| MIRA-1 | MIRA-1 is a maleimide-derived compound that reactivates the tumor suppressor function of mutant p53. It can induce apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 with IC50 value of 10 μM in vitro. Synonyms: NSC19630; NSC-19630; NSC 19630; MIRA-1; MIRA1; MIRA 1; 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione. Grades: ≥98% by HPLC. CAS No. 72835-26-8. Molecular formula: C8H9NO4. Mole weight: 183.16. | |
| Miramistin | Miramistin is a topical antiseptic. Synonyms: Benzenemethanaminium, N,N-dimethyl-N-[3-[(1-oxotetradecyl)amino]propyl]-, chloride (1:1); Ammonium, benzyldimethyl(3-myristamidopropyl)-, chloride; Benzenemethanaminium, N,N-dimethyl-N-[3-[(1-oxotetradecyl)amino]propyl]-, chloride; Benzyldimethyl(3-tetradecamidopropyl)ammonium chloride; Benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride; DT 2; DT 2 (surfactant). Grades: 95%. CAS No. 15809-19-5. Molecular formula: C26H47ClN2O. Mole weight: 439.12. | |
| Miriplatin hydrate | Miriplatin (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Miriplatin is a lipophilic platinum complex that can be easily suspended in Lipiodol and gradually releases active platinum compounds in tumor tissue. Miriplatin is less severe toxicity profile compared to other platinum anticancer agents. Synonyms: Miripla; Miriplatin; SM 11355; SM11355; SM-11355; MTP. Grades: >98%. CAS No. 250159-48-9. Molecular formula: C34H70N2O5Pt. Mole weight: 782.01. | |
| Mitochonic Acid 5 | Mitochonic Acid 5 is an effective mitochondrial ATP production enhancer. It binds to mitochondria and improves renal tubular and cardiomyocyte damage. Synonyms: Mitochonic Acid 5(MA-5); SCHEMBL15747705; MA-5; MA 5; MA5. Grades: 98%. CAS No. 1354707-41-7. Molecular formula: C18H13F2NO3. Mole weight: 329.3. | |
| MitoE10 | MitoE10, a mitochondria-targeted antioxidants comprising a lipophilic triphenylphosphonium cation attached to the antioxidant chroman moiety of vitamin E by an alkyl linker, was synthesised starting from 1-hydroxy-11-dodecyne, obtained by the addition of 1-bromononane to lithiated propargyl THP ether followed by triple bond migration using NaH and ethylenediamine. Preliminary biological data demonstrate that MitoE10 shows greater efficacy in preventing lipid peroxidation, mitochondrial oxidative damage and damage to mitochondrial DNA than non-targeted compounds. Synonyms: (10-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)decyl)triphenylphosphonium methanesulfonate; MitoE10; Mito E10; MitoE-10; Vitaman E-triphenylphosphonium conjugate; 1810703-64-0 (mesylate salt); 1810703-63-9 (cation). Grades: >98%. CAS No. 1810703-63-9. Molecular formula: C42H55O5PS. Mole weight: 702.93. | |
| Mitoguazone dihydrochloride monohydrate | Mitoguazone dihydrochloride monohydrate (CAS# 332360-02-8 ) is a useful research chemical. Synonyms: Methylglyoxal bis(guanylhydrazone) hydrate dihydrochloride; 2,2'-(1-Methyl-1,2-ethanediylidene) bis(hydrazinecarboximidamide) dihydrochloride hydrate; Methylglyoxal bis(guanylhydrazone) dihydrochloride hydrate; Methyl GAG dihydrochloride monohydrate; Methylglyoxal bis(guanylhydrazone) dihydrochloride monohydrate; 2,2'-(Propane-1,2-diylidene)di(hydrazine-1-carboximidamide)-hydrogen chloride-water. CAS No. 332360-02-8. Molecular formula: C5H16Cl2N8O. Mole weight: 275.14. | |
| Mivacurium | Mivacurium is a bisbenzylisoquinolinium based and a short-duration non-depolarizing neuromuscular-blocking drug or skeletal muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, which results in a block of neuromuscular transmission. It is used in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during mechanical ventilation or surgery. Uses: Mivacurium is a short-duration non-depolarizing neuromuscular-blocking drug or skeletal muscle relaxant. Synonyms: 2, 2'-[ (1, 8-Dioxo-4-octene-1, 8-diyl) bis (oxy-3, 1-propanediyl) ]bis[1, 2, 3, 4-tetrahydro-6, 7-dimethoxy-2-methyl-1-[ (3, 4, 5-trimethoxyphenyl) methyl]isoquinolinium; Isoquinolinium, 2,2'-((1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl))bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-((3,4,5-trimethoxyphenyl)methyl)-;Bis[3-[(1R)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propyl] (E)-oct-4-enedioate;BW-B-1090U;Mivacron;(1R,1'R)-2,2'-((((E)-oct-4-enedioyl)bis(oxy))bis(propane-3,1-diyl))bis(6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-2-ium). Grades: 95%. CAS No. 106791-40-6. Molecular formula: C58H80N2O14. Mole weight: 1029.28. | |
| MJN110 | MJN110 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor that modulates the synaptic processes. MJN110 has the potential for the treatment of acute nausea and vomiting as well as anticipatory nausea by elevation of endogenous cannabinoid 2-arachidonoylglycerol (2-AG) levels in the brain. Uses: Antihyperalgesic agent. Synonyms: MJN-110; MJN 110; MJN110;2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate. Grades: 98%. CAS No. 1438416-21-7. Molecular formula: C22H21Cl2N3O4. Mole weight: 462.33. | |
| MJN228 | MJN228 is a selective ligand for the lipid-binding protein nucleobindin 1 (NUCB1) that blocks probe binding to NUCB1. It prevents AEA-DA probe labeling of NUCB1 with an IC50 value of 3.3 μM in HEK293T cell lysates. Synonyms: (4-methylpiperazin-1-yl)-(5-nitro-3-phenyl-1H-indol-2-yl)methanone. Grades: ≥98%. CAS No. 459168-97-9. Molecular formula: C20H20N4O3. Mole weight: 364.4. | |
| MK-0359 | MK-0359 is a selective and potent oral PDE4 inhibitor with in vivoefficacy in animal models of asthma and cognition. Uses: Pde4 inhibitor. Synonyms: MK0359; MK 0359; MK-0359; L454560; L 454560; L-454560; 3-methyl-5-[(E)-1-(4-methylsulfonylphenyl)-2-[3-[6-(2-methylsulfonylpropan-2-yl)quinolin-8-yl]phenyl]ethenyl]-1,2,4-oxadiazole. Grades: ≥98%. CAS No. 346629-30-9. Molecular formula: C31H29N3O5S2. Mole weight: 587.15. | |
| MK 0434 | MK 0434 is a Cholestenone 5-alpha reductase inhibitor originated by Merck & Co and it is associated with a significant reduction in dihydrotestosterone. No development was reported for the treatment of Alopecia, Benign prostatic hyperplasia and Prostate cancer. Uses: Alopecia, benign prostatic hyperplasia and prostate cancer. Synonyms: MK0434; MK-0434; MK 0434; MK-434; MK434; MK 434; (4aR,4bS,6aS,7S,9aS,9bS,11aR)-7-benzoyl-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-2H-indeno[5,4-f]quinolin-2-one;(5alpha,17beta)-17-Benzoyl-4-azaandrost-1-en-3-one;17beta-Benzoyl-4-aza-5alpha-androst-1-ene-3-one. Grades: 98%. CAS No. 134067-56-4. Molecular formula: C25H31NO2. Mole weight: 377.53. | |
| MK-0493 | MK-0493 is a novel, potent, and selective agonist of MC4R( melanocortin receptor 4) , which is one of the best-validated genetic targets and considered one of the most promising for the development of antiobesity therapeutics. Uses: Anti-obesity. Synonyms: MK0493; MK 0493; MK-0493; N-((S)-1-(2-(1-((3S,4R)-1-(tert-butyl)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperidin-4-yl)-5-chlorophenyl)ethyl)acetamide hydrochloride. Grades: ≥98%. CAS No. 455957-71-8. Molecular formula: C30H39Cl2F2N3O2. Mole weight: 582.55. | |
| MK-0493 Free base | MK-0493 is a novel, potent, and selective agonist of the melanocortin receptor 4 (MC4R), one of the best-validated genetic targets and considered one of the most promising for the development of antiobesity therapeutics. Uses: Undefined mechanism. Synonyms: MK0493; MK 0493; MK-0493; N-((S)-1-(2-(1-((3S,4R)-1-(tert-butyl)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperidin-4-yl)-5-chlorophenyl)ethyl)acetamide. Grades: ≥98%. CAS No. 455956-93-1. Molecular formula: C30H38ClF2N3O2. Mole weight: 546.09. | |
| MK 0557 | MK-0557 is a highly selective, orally administered neuropeptide NPY5R antagonist, could limit weight regain after very-low-calorie diet (VLCD)-induced weight loss. Uses: Npy5r antagonist. Synonyms: MK0557; MK 0557; MK-0557; N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide. Grades: ≥98%. CAS No. 328232-95-7. Molecular formula: C22H19FN4O3. Mole weight: 406.41. | |
| MK0873 | MK0873 is a phosphodiesterase 4 (PDE4) inhibitor. It has shown as an innovative tool to design topical formulation to achieve desired pharmacokinetics in humans along with a minipig skin biopsy model. It was developed by Merck. It was used to treat rheumatoid arthritis in phase II clinical trials and plaque psoriasis in phase I clinical trials, but it has no recent research progress. Uses: Mk0873 was used to treat rheumatoid arthritis and plaque psoriasis. Synonyms: N-cyclopropyl-1-[3-[2-(1-oxidopyridin-1-ium-3-yl)ethynyl]phenyl]-4-oxo-1,8-naphthyridine-3-carboxamide;MK0873; MK 0873; MK-0873;3-((3-(3-(cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)phenyl)ethynyl)pyridine 1-oxide. Grades: 98%. CAS No. 500355-52-2. Molecular formula: C25H18N4O3. Mole weight: 422.44. | |
| MK 0927 | MK 0927 is a potential bio-active agent., but no detail information has been published yet. Synonyms: MK0927; MK-0927; MK 0927; 4-(2-methylpropylamino)-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide;hydrochloride. Grades: 98%. CAS No. 126453-94-9. Molecular formula: C11H19ClN2O4S3. Mole weight: 374.91. | |
| MK-142 dimethanesulfonate | MK-142 is a bioactive agent with antiarrhythmic properties with its content in the skeletal muscles indicates a high affinity of the examined substance to the heart muscle. Uses: Antiarrhytmic. Synonyms: MK142; MK-142; MK 142; 3,3'-(ethane-1,2-diylbis(azanediyl))bis(1-(4-methoxyphenoxy)propan-2-ol). Grades: ≥95%. CAS No. 42794-63-8. Molecular formula: C22H32N2O6. Mole weight: 420.50. | |
| MK190 | MK190 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: MK190; MK-190; MK 190; 2-(4-fluorophenyl)-1-methyl-5-nitro-1H-imidazole. Grades: ≥98%. CAS No. 4204-99-3. Molecular formula: C10H8FN3O2. Mole weight: 221.19. | |
| MK 1-907 | MK-1-907 is a centrally acting drug, but no detailed information has been published yet. Uses: Centrally acting drug. Synonyms: MK1907; MK-1-907; MK-1907; MK1-907; MK-1-907; 3- ( (3-methoxyphenyl)amino)-5, 5-dimethyl-2- ( (methyl (phenethyl)amino)methyl)cyclohex-2-en-1-one. Grades: 98%. CAS No. 78150-06-8. Molecular formula: C25H32N2O2. Mole weight: 392.54. | |
| MK2-IN-1 | MK2-IN-1, a selective MAPKA-PK2 inhibitor, could probably influence the formation of proinflammatory cytokines. IC50: 0.11 uM. Uses: Mk2-in-1 is a selective mapka-pk2 inhibitor that could probably influence the formation of proinflammatory cytokines. Synonyms: MK2 Inhibitor. Grades: 98%. CAS No. 1314118-92-7. Molecular formula: C27H25ClN4O2. Mole weight: 472.97. | |
| MK2-IN-1 hydrochloride | The hydrochloride salt form of MK2-IN-1 which is a selective MAPKA-PK2 inhibitor and could probably influence the formation of proinflammatory cytokines. IC50: 0.11 uM. Uses: The hydrochloride salt form of mk2-in-1 which is a selective mapka-pk2 inhibitor and could probably influence the formation of proinflammatory cytokines. Synonyms: MK25; MK-25; MK 25; MK2 Inhibitor IV; MK2 Inhibitor-IV; MK2 Inhibitor. Grades: 98%. CAS No. 1314118-94-9. Molecular formula: C27H26Cl2N4O2. Mole weight: 509.43. | |
| MK2 Inhibitor III | MK2 inhibitor III is a cell-permeable and ATP-competitive inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2). It was shown to block LPS-induced synthesis of TNF-α in human monocyte-like U937 cells with IC50 value of 4.4 μM. Synonyms: 2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate. Grades: ≥95%. CAS No. 1186648-22-5. Molecular formula: C21H16N4O·H2O. Mole weight: 358.4. | |
| MK-3328 | This molecular has a favorable potency versus human β-amyloid plaque and has been radiolabeled for further evaluation in in vitro binding and in vivo PET imaging experiments. Studies led to the identification of MK-3328 as a candidate PET ligand for the clinical assessment of β-amyloid plaque load. In Aug 2009, Phase-I clinical trials in Alzheimer's disease in Belgium was on-going, but no recent reported has been published yet. Uses: Alzheimer's disease. Synonyms: MK3328; MK 3328; MK-3328; 5-fluoro-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)oxazolo[5,4-b]pyridine. Grades: 98%. CAS No. 1201323-97-8. Molecular formula: C14H9FN4O. Mole weight: 268.25. | |
| MK 410 | MK 410 is an anti-inflammatory drug which can induce alterations in the immune system by the suppression of plasma neutral proteinase activity. Uses: Anti-inflammatory. Synonyms: MK-410; MK 410; MK410; 2-(5-methoxy-2-methyl-1-(4-(methylthio)benzyl)-1H-indol-3-yl)propanoic acid. Grades: ≥98%. CAS No. 40738-05-4. Molecular formula: C21H23NO3S. Mole weight: 369.47. | |
| MK-4101 | MK-4101 is a potent and selective SMO Inhibitor of the Hedgehog Pathway with anti-tumor activity. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1 MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors. Synonyms: 5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole; MK-4101; MK 4101; MK4101. Grades: >98%. CAS No. 935273-79-3. Molecular formula: C24H24F5N5O. Mole weight: 493.48. | |
| MK 436 | MK436 is an anti-protozoal drug has been found to be effective against Trypanosoma cruzi infections. Uses: A therapeutic agent and an anti-protozoal drug. Synonyms: MK-436; MK 436; MK436; 3-(1-methyl-5-nitro-1H-imidazol-2-yl)-3a,4,5,6,7,7a-hexahydrobenzo[d]isoxazole. Grades: ≥98%. CAS No. 33450-08-7. Molecular formula: C11H14N4O3. Mole weight: 250.10. | |
| MK-4827 (R-enantiomer) | MK-4827 (R-enantiomer) is the R form of MK-4827, which is a PARP inhibitor developed for the treatment of ovarian cancer. Synonyms: (R)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide; Niraparib R-enantiomer; MK4827 R-enantiomer; MK 4827 R-enantiomer; MK-4827 R-enantiomer. Grades: > 98%. CAS No. 1038915-58-0. Molecular formula: C19H20N4O. Mole weight: 320.396. | |
| MK-4827 tosylate | MK-4827 tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. It has a great activity in cancer cells with mutant BRCA-1 and BRCA-2, >330-fold selective against PARP3, V-PARP and Tank1. Synonyms: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate; MK-4827; MK-4827; MK4827; MK4827-tosylate; Niraparib tosylate. Grades: >98%. CAS No. 1038915-73-9. Molecular formula: C26H28N4O4S. Mole weight: 492.59. | |
| MK 571 | MK-571 is a CysLT1 receptor antagonist. It can be used for the treatment of respiratory diseases. Uses: Leukotriene antagonists. Synonyms: MK 571; MK571; MK-571; 3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid. Grades: ≥98% by HPLC. CAS No. 115104-28-4. Molecular formula: C26H27ClN2O3S2. Mole weight: 515.09. | |
| MK-7145 dihydrochloride | MK-7145 is a potent, selective and orally active ROMK inhibitor for the treatment of hypertension and heart failure. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50 > 30 μM). Synonyms: MK-7145 dihydrochloride; MK 7145 dihydrochloride; MK7145 dihydrochloride. Grades: 98%. CAS No. 1255204-85-3. Molecular formula: C26H30N2O6.2HCl. Mole weight: 544.534. | |
| MK785 | MK785, an imidazol derivative, has been found to inhibit the formation of aortic histamine through influencing the aortic histidine decarboxylase at some extent. Synonyms: 2-hydrazinyl-3-(1h-imidazol-5-yl)propanoic acid; MK-785; MK 785; MK785; AC1Q5SMC; 2-Hydrazino-3-(4(5)-imidazole)propionic acid. Grades: 98%. CAS No. 14760-71-5. Molecular formula: C6H10N4O2. Mole weight: 170.17. | |
| MK-8353 | MK-8353 is an orally available ERK1/2 inhibitor. It exhibited antitumor activity in patients with BRAFV600-mutant melanoma. Synonyms: (3S)-3-(methylthio)-1-[2-[4-[4-(1-methyl-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl]-N-[3-(6-propan-2-yloxy-3-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide. CAS No. 1184173-73-6. Molecular formula: C37H41N9O3S. Mole weight: 691.84. | |
| MK-8718 | MK-8718 has been found to be a HIV protease inhibitor and could be studied in HIV research. Synonyms: MK-8718; MK 8718; MK8718; ((3S,6R)-6-(2-(3-((2S,3S)-2-amino-3-(4-chlorophenyl)-3-(3,5-difluorophenyl)propanamido)-5-fluoropyridin-4-yl)ethyl)morpholin-3-yl)methyl (2,2,2-trifluoroethyl)carbamate. Grades: 98%. CAS No. 1582729-24-5. Molecular formula: C30H30ClF6N5O4. Mole weight: 674.04. | |
| MK-8718 HCl | The hydrochloride salt form of MK-8718 which has been found to be a HIV protease inhibitor and could be studied in HIV research. Synonyms: MK-8718 HCl; MK 8718 HCl; MK8718 HCl. Grades: 98%. CAS No. 1582732-29-3. Molecular formula: C30H31Cl2F6N5O4. Mole weight: 710.54. | |
| MK-B 251 | MK-B 251 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: MKB251; MKB 251; MK-B251; MK B 251;MKB-251; MK-B-251; MK-B 251; 2-[4-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]propan-2-amine;hydrochloride. Grades: ≥98%. CAS No. 40396-69-8. Molecular formula: C17H18ClF4N. Mole weight: 347.78. | |
| ML-031 | ML-031 is a S1P2 agonist with EC50 value of 1 μM in a S1P reporter assay. Synonyms: ML 031; ML031; CID-2113511; 1-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione. Grades: ≥95%. CAS No. 852230-33-2. Molecular formula: C19H20N2O3. Mole weight: 324.4. | |
| ML-095 hydrochloride | ML-095 is an inhibitor of placental alkaline phosphatase (PLAP) with IC50 value of 3.7 μM. Synonyms: ML-095 HCl; ML 095 hydrochloride; ML095 hydrochloride; CID-25067483; 1-(3,4-dihydroxyphenyl)-2-(2-ethylimidazol-1-yl)ethanone hydrochloride. Grades: ≥98%. CAS No. 1135318-57-8. Molecular formula: C13H14N2O3·HCl. Mole weight: 282.7. | |
| ML-098 | ML-098, also called as CID-7345532, is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) with selectivity without disrupting related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively). Synonyms: 1-[2-(2,5-dimethylphenoxy)ethyl]indole-3-carboxylic acid; ML 098; ML098; CID-7345532; CID 7345532; CID7345532. CAS No. 878978-76-8. Molecular formula: C19H19NO3. Mole weight: 309.36. | |
| ML141 | ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM. Synonyms: Ro111163; Ro-111163; Ro 111163; ML-141; ML 141; ML141; CID2950007; CID-2950007; CID 2950007. Grades: >98%. CAS No. 71203-35-5. Molecular formula: C22H21N3O3S. Mole weight: 407.49. | |
| ML 145 | ML 145 is a GPR35 orphan receptor antagonist with IC50 value of 20.1 nM. It can be used in the treatment of disorders affecting the stomach as well as the immune system. Synonyms: ML 145; ML145; ML-145; 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid. Grades: ≥98% by HPLC. CAS No. 1164500-72-4. Molecular formula: C24H22N2O5S2. Mole weight: 482.57. | |
| ML 154 | ML 154 is a neuropeptide S receptor antagonist. It has the potential to be used in the treatment of sleep, anxiety and addiction disorders. Synonyms: NCGC 84; NCGC84; NCGC-84; ML 154; ML154; ML-154; NCGC00185684. 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide. Grades: ≥99% by HPLC. CAS No. 1345964-89-7. Molecular formula: C29H26N2PS.Br. Mole weight: 545.47. | |
| ML-162 | ML-162 is a GPX4 inhibitor that selectively kills cells induced to express mutant RAS. GPX4 is a regulator of ferroptosis (iron-dependent, non-apoptotic cell death). Synonyms: ML 162; ML162; 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide. Grades: ≥95%. CAS No. 1035072-16-2. Molecular formula: C23H22Cl2N2O3S. Mole weight: 477.4. | |
| ML-178 | ML-178 is a selective S1P4 activator with EC50 value of 46.3 nM without effect against S1P1, S1P2, S1P3, and S1P5. Synonyms: ML 178; ML178; CID 44620892; CYM 50179; SID 87544119; 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]pyridine. Grades: ≥95%. CAS No. 1355026-47-9. Molecular formula: C13H9Br2Cl2NO2. Mole weight: 441.9. | |
| ML 179 | ML 179 is a liver receptor homolog 1 inverse agonist with IC50 value of 320 nM. Synonyms: ML 179; ML179; ML-179; 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione. Grades: ≥99% by HPLC. CAS No. 1883548-87-5. Molecular formula: C21H25F3N4O2. Mole weight: 422.44. | |
| ML-180 | ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1) that inhibits cell proliferation. Synonyms: ML 180; ML180; CID-3238389; SR1848; 6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione. Grades: ≥98%. CAS No. 863588-32-3. Molecular formula: C20H25ClN4O2. Mole weight: 388.9. | |
| ML-191 | ML-191 is a GPR55 antagonist inhibiting LPI-induced phosphorylation of ERK1/2 and blocking receptor-dependent translocation of PKCβII. Synonyms: ML 191; ML191; CCG-152883; CID-23612552; 3-[1-[[1-(4-Methylphenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one. Grades: ≥98%. CAS No. 931695-79-3. Molecular formula: C24H25N3O3. Mole weight: 403.5. | |
| ML192 | ML192 is a selective ligands for GPR55 with 1080 nM potency for GPR55 and >45-fold antagonist and agonist selectivity against GPR35, CB1 and CB2. Uses: Potent and selective antagonist for gpr55. Synonyms: ML192; ML 192; ML-192; CID1434953; CID-1434953; CID 1434953; MLS000526305. furan-2-yl(4-(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl)methanone. Grades: ≥98%. CAS No. 460331-61-7. Molecular formula: C20H22N4O2S. Mole weight: 382.48. | |
| ML 193 | ML 193 is a GPR55 antagonist with IC50 value of 221 nM. Synonyms: ML-193; ML 193; ML193; CID 1261822; CID-1261822; CID1261822; N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide. Grades: ≥98% by HPLC. CAS No. 713121-80-3. Molecular formula: C28H25N5O4S. Mole weight: 527.59. | |
| ML-211 | ML-211 is a dual inhibitor of LYPLA1 and the related LYPLA2 with IC50 of 17 and 30 nm. ML-211 could inhibit the serine hydrolase ABHD11 with IC50 of 10 nM but was over 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases. Synonyms: Methanone, [4-(1,1-dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-; [4-(1,1-Dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]methanone; {4-[Hydroxy(diphenyl)methyl]-2H-1,2,3-triazol-2-yl}[4-(2-methyl-2-propanyl)-1-piperidinyl]methanone; (4-(tert-butyl)piperidin-1-yl)(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)methanone. Grades: >98%. CAS No. 2205032-89-7. Molecular formula: C25H30N4O2. Mole weight: 418.53. | |
| ML216 | Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom's Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells. Synonyms: ML 216; ML-216; CID-49852229; CID49852229; CID 49852229. Grades: >98%. CAS No. 1430213-30-1. Molecular formula: C15H9F4N5OS. Mole weight: 383.32. | |
| ML-226 | ML-226 is an inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with 100-fold greater selectivity for ABHD11 over approximately 20 other serine hydrolases. It can be used as an anti-probe for ML-211. Synonyms: ML 226; ML226; (2-Ethylpiperidin-1-yl)-[4-[hydroxy(diphenyl)methyl]triazol-2-yl]methanone. Grades: ≥98%. CAS No. 2055172-43-3. Molecular formula: C23H26N4O2. Mole weight: 390.48. | |
| ML-23 | ML-23 is a melatonin analogue. It is a potential clinical candidate for the treatment of Parkinson's disease. It produced a significant remission from MPTP-induced Parkinsonism and this effect did not abate when the treatment was withdrawn on all parameters. Uses: Ml-23 is a potential clinical candidate for the treatment of parkinson's disease. Synonyms: ML-23; ML23; ML 23; N-(3,5-Dinitrophenyl)-5-methoxy-1H-indole-3-ethanamine;N-(2,4-Dinitrophenyl)-5-methoxytryptamine;1H-Indole-3-ethanamine,N-(2,4-dinitrophenyl)-5-methoxy-;ML23;N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-3,5-dinitroaniline. Grades: >98%. CAS No. 108929-03-9. Molecular formula: C17H16N4O5. Mole weight: 356.34. | |
| ML240 | ML240, a quinazoline derivative, has been found to be a p97 ATPase inhibitor and probably be effective against colon cancer and show antiproliferative activity in NCI-60 cancer cell lines. IC50: 100 nM. Uses: Ml240 has been found to be a p97 atpase inhibitor and probably be effective against colon cancer and show antiproliferative activity in nci-60 cancer cell lines. Synonyms: ML240; ML-240; ML 240. MLS003568129; KUC107871N; SMR002239184; 2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine; 2nd batch of KSC-16-270. Grades: 95%. CAS No. 1346527-98-7. Molecular formula: C23H20N6O. Mole weight: 396.44. | |
| ML241 | ML241 is a selective p97 ATPase inhibitor and IC50 value is 100 nM. It can inhibit degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the treatment of cancer. Uses: Anticancer. Synonyms: 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine; ML241; ML-241; ML 241. Grades: 98%. CAS No. 1346528-06-0. Molecular formula: C23H24N4O. Mole weight: 372.46. | |
| ML241 HCl | ML241 is identified as a potent and selective inhibitors of p97 ATPase (IC(50)= 100 nM). ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 could impair the endoplasmic-reticulum-associated degradation (ERAD) pathway. Synonyms: 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine hydrochloride; ML241; ML-241; ML 241; ML241 HCl; ML241 hydrochloride. CAS No. 2070015-13-1. Molecular formula: C23H25ClN4O. Mole weight: 408.93. | |
| ML264 | ML264 is a Krüppel-like factor 5 (KLF5) inhibitor with the potential to inhibits growth of colorectal cancer. It reduces EGR1 and KLF5 levels so that ML264 inhibits the MAPK pathway. in a cell-based assay for proliferation of DLD-1 cells: IC50 = 29 nM, in. Synonyms: (E)-3-(3-chlorophenyl)-N-[2-[(1,1-dioxothian-4-yl)-methylamino]-2-oxoethyl]prop-2-enamideML264; ML264; ML 264; MLS003874889SCHEMBL15605936SCHE MBL17045845CS-5628; CS 5628; CS5628HY-19994; HY 19994; HY19994SMR002531696SR-03000002171SR-03000002171-1(E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-. CAS No. 1550008-55-3. Molecular formula: C17H21ClN2O4S. Mole weight: 384.88. | |
| ML281 | ML281, a quinoxalin derivative, has been found to be a STK33 inhibitor and could have probable effect against KRAS-dependent cancers. IC50: 14 nM. Uses: Ml281 has been found to be a stk33 inhibitor and could have probable effect against kras-dependent cancers. Synonyms: ML-281; ML-281; ML281. CHEMBL2204239; Bg-stk33-59; MLS003876599; BRD8942; BRD-8942. Grades: 98%. CAS No. 1404437-62-2. Molecular formula: C22H19N3O2S. Mole weight: 389.47. | |
| ML-290 | ML-290 is an allosteric agonist of relaxin family peptide receptor 1 (RXFP1). It increases cAMP accumulation and VEGF expression in cells that endogenously express human RXFP1. ML290 exhibits antifibrotic effects in liver fibrosis. Synonyms: ML 290; ML290; RXFP1 Agonist 8??; 2-[ (2-propan-2-yloxybenzoyl) amino]-N-[3- (trifluoromethylsulfonyl) phenyl]benzamide. Grades: ≥95%. CAS No. 1482500-76-4. Molecular formula: C24H21F3N2O5S. Mole weight: 506.5. | |
| ML-291 | ML-291 is a novel activator of the apoptotic arm of the unfolded protein response (UPR), but not the adaptive arm. It induces apoptosis in mouse embryonic fibroblasts overexpressing CHOP, but not in wild-type or CHOP knockout cells. Synonyms: ML 291; ML291; N-(4-((4-chloropiperidin-1-yl)sulfonyl)phenyl)-5-nitrofuran-2-carboxamide. Grades: ≥98%. CAS No. 1523437-16-2. Molecular formula: C16H16ClN3O6S. Mole weight: 413.8. | |
| ML329 | ML329 is a small molecule MITF inhibitor that inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 inhibits TRPM-1 promoter activity (IC50 = 1.2 μM). Synonyms: 4-[(1,4-dioxonaphthalen-2-yl)amino]benzenesulfonamide; ML329; ML 329; ML-329. CAS No. 19992-50-8. Molecular formula: C16H12N2O4S. Mole weight: 328.34. | |
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