MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Rilmenidine phosphate | Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na + /H + antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 85409-38-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100490B. |  |
| Rilonacept | Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Arcalyst; IL 1 Trap; Interleukin 1 Trap. CAS No. 501081-76-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-108822. | |
| Rilotumumab | Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocyte growth factor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG 102. CAS No. 872514-65-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99217. | |
| Rilpivirine | Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor ( NNRTI ). Rilpivirine has high antiviral activity against wild-type HIV ( EC 50 =0.4 nM) and mutant viruses ( EC 50 =0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R278474; TMC278; DB08864. CAS No. 500287-72-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10574. | |
| Rilpivirine hydrochloride | Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor ( NNRTI ). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV ( EC 50 =0.4 nM) and mutant viruses ( EC 50 =0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC-278 hydrochloride; TMC278 hydrochloride; TMC 278 hydrochloride. CAS No. 700361-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10574A. | |
| Riluzole | Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC 50 of 43 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PK 26124. CAS No. 1744-22-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0211. | |
| Riluzole hydrochloride | Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC 50 of 43 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PK 26124 hydrochloride. CAS No. 850608-87-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0211A. | |
| Riluzole (Standard) | Riluzole (Standard) is the analytical standard of Riluzole. This product is intended for research and analytical applications. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC 50 of 43 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PK 26124 (Standard). CAS No. 1744-22-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0211R. | |
| Rimantadine | Rimantadine is an orally active inhibitor for M2 protein , that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Rimantadine. CAS No. 13392-28-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg. Product ID: HY-B0338. | |
| Rimantadine hydrochloride | Rimantadine hydrochloride (Flumadine hydrochloride) is an orally active inhibitor for M2 protein , that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1501-84-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-B0338A. | |
| Rimcazole dihydrochloride | Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BW 234U dihydrochloride. CAS No. 75859-03-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108510. | |
| Rimegepant | Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide ( CGRP ) receptor antagonist with a K i of 0.027 nM and an IC 50 of 0.14 nM for hCGRP receptor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-927711; BHV-3000. CAS No. 1289023-67-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15498. | |
| Rimeporide | Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na + /H + exchanger (NHE-1). Uses: Scientific research. Group: Signaling pathways. Alternative Names: EMD-87580. CAS No. 187870-78-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-19273. | |
| Rimiducid | Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AP1903. CAS No. 195514-63-7. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16046. | |
| Rimonabant | Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a K i of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3). Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR141716. CAS No. 168273-06-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14136. | |
| Rimonabant Hydrochloride | Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an K i of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3). Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR 141716A Hydrochloride. CAS No. 158681-13-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14137. | |
| Rimsulfuron | Rimsulfuron (DPX-E9636) is a sulfonylurea herbicide for postemergence use in maize to control grasses and some broadleaf weeds [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DPX-E9636. CAS No. 122931-48-0. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-133085. | |
| Rinatabart | HY-P990941 is an FOLR1 -targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2853518-94-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990941. | |
| Rintodestrant | Rintodestrant (G1T48) is an orally active, non-steroidal and selective estrogen receptor degrader. Rintodestrant (G1T48) is also a CDK4/6 inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: G1T48. CAS No. 2088518-51-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137449. | |
| Rinzimetostat | Rinzimetostat (ORIC-944) is a selective, orally active, allosteric inhibitor targeting the EED subunit of polycomb repressive complex 2 (PRC2). Rinzimetostat is synergistic with androgen receptor pathway inhibitors (ARPIs) for the study of metastatic prostate cancer. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ORIC-944. CAS No. 2369769-29-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158102. | |
| Riociguat | Riociguat is an oral stimulator of soluble guanylate cyclase ( sGC ) used in the treatment of pulmonary hypertension. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 632521. CAS No. 625115-55-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14779. | |
| RIP1/RIP3/MLKL activator 1 | RIP1/RIP3/MLKL activator 1 (Compound 6i) is a potent anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. RIP1/RIP3/MLKL activator 1 exerts acceptable BBB permeability[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2682850-41-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144828. | |
| RIPA-56 | RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interactingprotein 1 (RIP1) with an IC50 of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1956370-21-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-101032. | |
| Ripasudil | Ripasudil (K-115) is a specific inhibitor of ROCK , with IC 50 s of 19 and 51 nM for ROCK2 and ROCK1 , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: K-115. CAS No. 887375-67-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15685. | |
| RIPK1-IN-19 | RIPK1-IN-19 (compound 10b) is a selective RIPK1 inhibitor ( IC 50 =15 nM). RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ)-induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2763831-43-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157456. | |
| RIPK-IN-4 | RIPK-IN-4 is a selective RIPK2 inhibitor with an IC50 value of 3 nM. RIPK-IN-4 can be used for the research of inflammatory diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2141969-56-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-107978. | |
| Ripretinib | Ripretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor. Ripretinib (DCC-2618) targets and binds to both wild-type and mutant forms of KIT and PDGFRA specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. Ripretinib (DCC-2618) also inhibits multiple other kinase targets, such as FLT3 and KDR (or VEGFR-2) [1] [2]. DCC-2618 exerts antineoplastic effect and induces apoptosis [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DCC-2618. CAS No. 1442472-39-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112306. | |
| Risankizumab | Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit ( K d <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC 50 = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Risankizumab rzaa; BI 655066. CAS No. 1612838-76-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99248. | |
| Risdiplam | Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG7916; RO7034067. CAS No. 1825352-65-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109101. | |
| Risedronic acid | Risedronic acid (Risedronate), a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid inhibits blood stages of Plasmodium falciparum ( IC 50 of 20.3 μM). Risedronic acid inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Risedronate. CAS No. 105462-24-6. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B0148. | |
| Risedronic acid sodium | Risedronic acid (Risedronate) sodium, a bisphosphonate, is a potent anti-resorption agent that inhibits osteoclast-mediated bone resorption and changes the bone metabolism. Risedronic acid sodium suppresses osteoblast differentiation and induced caspase- and isoprenoid depletion-dependent apoptosis. Risedronic acid sodium inhibits blood stages of Plasmodium falciparum ( IC 50 of 20.3 μM). Risedronic acid sodium inhibits the transfer of the farnesyl pyrophosphate group to parasite proteins [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Risedronate sodium. CAS No. 115436-72-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B0119. | |
| (R)-Isomucronulatol | (R)-Isomucronulatol is a natural flavonoid that could be isolated from the seeds of sphaerophysa salsula [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Isomucronulatol; 2H-1-Benzopyran-7-ol. CAS No. 64474-51-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2495A. | |
| Risperidone | Risperidone is a serotonin 5-HT 2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D 2 receptor antagonist, with K i s of 4.8, 5.9 nM for 5-HT 2A and dopamine D 2 receptor, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 64 766. CAS No. 106266-06-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-11018. | |
| Risperidone-d4 | Risperidone-d 4 is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: R 64 766-d4. CAS No. 1020719-76-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-110232. | |
| Ristocetin | Ristocetin is a glycopeptide antibiotic. Ristocetin induces platelet aggregation. Ristocetin can be used for Research of Von Willebrands disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1404-55-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-150523. | |
| Risvodetinib | Risvodetinib (IkT-148009) is an orally active, selective and brain-penetrant protein tyrosine kinase inhibitor, displaying excellent target efficacy against c-Abl1 , c-Abl2/Arg with IC 50 values of 33 nM, 14 nM, respectively. Risvodetinib suppresses c-Abl activation and substantially protects dopaminergic neurons from degeneration in mouse models of both inherited and sporadic Parkinsons disease (PD), which is promising for research in the field of PD [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IkT-148009. CAS No. 2031185-00-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148794. | |
| RITA | RITA is an inhibitor of p53-HDM-2 interaction , binds to p53dN, with a K d of 1.5 nM, and also induces DNA-DNA cross-links. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 652287. CAS No. 213261-59-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-13424. | |
| Ritalinic acid | Ritalinic acid (Ritalinate) is the main inactive urinary metabolite of Methylphenidate. Methylphenidate has the potential for attention-deficit hyperactivity disorder and narcolepsy research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ritalinate. CAS No. 19395-41-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W042214. | |
| Ritanserin | Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT 2 receptor , with an IC 50 of 0.9 nM, less active on Histamine H 1 , Dopamine D 2 , Adrenergic α 1 , Adrenergic α 2 receptors [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 55667. CAS No. 87051-43-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10791. | |
| Ritlecitinib | Ritlecitinib (PF-06651600) is an orally active and selective JAK3 inhibitor with an IC 50 of 33.1 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06651600. CAS No. 1792180-81-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100754. | |
| Ritlecitinib tosylate | Ritlecitinib tosylate is an orally active and selective JAK3 inhibitor with an IC 50 of 33.1 nM. Ritlecitinib tosylate is used for inflammatory and autoimmune diseases research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06651600 tosylate. CAS No. 2192215-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100754C. | |
| Ritodrine hydrochloride | Ritodrine (DU21220) hydrochloride is a potent and orally active β-adrenergic agonist. Ritodrine hydrochloride decreases preterm delivery and uterine contraction. Ritodrine hydrochloride has the potential for the research of preterm labor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DU21220 hydrochloride. CAS No. 23239-51-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0452. | |
| Ritolukast | Ritolukast (Wy-48252) is an orally active aerosol leukotriene ( LTD 4 /E 4 ) receptor antagonist. Ritolukast can be used to inhibit the bronchoconstriction caused by aerosol LTD 4 in guinea pigs, with an ID 50 of 0.5mg/kg [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Wy-48252. CAS No. 111974-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156978. | |
| Ritonavir | Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 1.61 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT 538; RTV. CAS No. 155213-67-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-90001. | |
| Ritonavir metabolite | Ritonavir metabolite is a metabolite of Ritonavir, which is a HIV protease inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Desthiazolylmethyloxycarbonyl Ritonavir. CAS No. 176655-55-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-G0009. | |
| Rituximab | Rituximab is an anti-CD20 chimeric monoclonal antibody used for research of certain autoimmune diseases and cancer. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human CD20 type I, Chimeric Antibody. CAS No. 174722-31-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9913. | |
| Rituximab (anti-CD20) | Rituximab (anti-CD20) is an anti-CD20 chimeric monoclonal antibody used to treat certain autoimmune diseases and types of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 174722-31-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9913A. | |
| Rivaroxaban | Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa ( FXa ) inhibitor, achieving a strong gain in anti-FXa potency ( IC 50 0.7 nM; K i 0.4 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 59-7939. CAS No. 366789-02-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-50903. | |
| Rivaroxaban EP Impurity I | Rivaroxaban EP Impurity I (Imp I) is the impurity reference for Rivaroxaban EP [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1151893-81-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-I0454. | |
| Rivastigmine | Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC 50 s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ENA 713 free base; SDZ-ENA 713 free base. CAS No. 123441-03-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-17368. | |
| Rivastigmine metabolite | Rivastigmine metabolite (NAP 226-90) is an acetylcholinesterase ( AChE ) inhibitor which is produced in kidney. Rivastigmine metabolite is promising for research of Alzheimers Disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NAP 226-90. CAS No. 139306-10-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W020576. | |
| Rivastigmine tartrate | Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC 50 s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ENA 713; SDZ-ENA 713. CAS No. 129101-54-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-11017. | |
| Rivoglitazone | Rivoglitazone is a thiazolidinedione-derivative PPARγ agonist for the research of type 2 diabetes mellitus. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R-106056. CAS No. 185428-18-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-106181. | |
| Rizatriptan benzoate | Rizatriptan benzoate is the agonist for 5-HT 1B and 5-HT 1D. Rizatriptan benzoate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK 462. CAS No. 145202-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0206. | |
| (R)-(-)-JQ1 Enantiomer | (R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect. Uses: Scientific research. Group: Signaling pathways. CAS No. 1268524-71-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13030A. | |
| RK-33 | RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1070773-09-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100455. | |
| RK-682 | RK-682 is the inhibitor for protein tyrosine phosphatase ( PTPase ), heparanase , phospholipase A2 and HIV-1 protease. RK-682 inhibits the dephosphorylation of CD45 ( IC 50 is 54 μM) and VHR ( IC 50 is 2.0 μM), and thereby inhibits the ERK signaling pathway. RK-682 inhibits the cell viability of cancer cell MGH-U3, T24 and UROtsa with IC 50 s of 78.2, 43.2 and 145 nM, respectively, arrests the cell cycle at G1/S phase, inhibits the cell migration and autophagy in MGH-U3 and T24 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 150627-37-5. Pack Sizes: 200 μg. Product ID: HY-135564A. | |
| RKI-1447 | RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC 50 values of 14.5 nM and 6.2 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1342278-01-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15755. | |
| RKI-1447 dihydrochloride | RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC 50 s of 14.5 and 6.2 nM for ROCK1 and ROCK2 , respectively [1]. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1782109-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110339. | |
| RL71 | RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1195795-93-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121605. | |
| (R)-Lansoprazole | (R)-Lansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dexlansoprazole. CAS No. 138530-94-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-13662B. | |
| RLY-2608 | RLY-2608 is an orally active first-in-class allosteric mutant-selective inhibitor of PI3Ka with anti-tumor activity. RLY-2608 inhibits tumor growth in PIK3CA-mutant xenograft mice models with minimal impact on insulin [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2733573-94-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153306. | |
| RMC-4550 | RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2172651-73-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116009. | |
| RMC-5552 | RMC-5552 is a potent and selective mTORC1 inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC 50 s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC 50 of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2382768-62-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-132168. | |
| RMC-6236 | RMC-6236 (Compound A122) is a potent RAS(ON) MULTI inhibitor. RMC-6236 can be used in lung adenocarcinoma research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RAS-IN-2. CAS No. 2765081-21-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148439. | |
| RMC-6272 | RMC-6272 (RM-006) is a bi-steric mTORC1-selective inhibitor. RMC-6272 exhibits potent and selective (> 10-fold) inhibition of mTORC1 over mTORC2. RMC-6272 shows improved inhibition of mTORC1 in comparison to Rapamycin, and induces more cell death in TSC2 null tumors[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RM-006. CAS No. 2382769-46-0. Pack Sizes: 1 mg; 10 mg. Product ID: HY-134904. | |
| RMC-7977 | RMC-7977 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (K d = 195 nM) and KRAS (G12V) (K d = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK , CRAF , and RSK , as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRAS G12C cancer models, and demonstrates good tolerability across various RAS cancer models [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2765082-12-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-156498. | |
| (R)-Methanandamide | (R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a K i of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AM-356. CAS No. 157182-49-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-101389. | |
| R(+)-Methylindazone | R(+)-Methylindazone (R(+)-IAA-94) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-Methylindazone inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef)[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R(+)-IAA-94. CAS No. 54197-31-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12693. | |
| (R)-MG-132 | (R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S,R,S)-(-)-MG-132; Z-Leu-D-Leu-Leu-al. CAS No. 1211877-36-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13259C. | |
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