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| Product | Description | |
|---|---|---|
| JWH 398 N-(4-Hydroxypentyl) Metabolite-d5 | JWH 398 N-(4-Hydroxypentyl) Metabolite-d5. Group: Biochemicals. Alternative Names: (4-Chloronaphthalen-1-yl)(1-(4-hydroxypentyl)-1H-indol-3-yl-2,4,5,6,7-d5)methanone. Grades: Highly Purified. Pack Sizes: 500ug. Molecular Formula: C24H17D5ClNO2, Molecular Weight: 396.92. US Biological Life Sciences. |  Worldwide |
| JWH 412 | JWH 412. Group: Biochemicals. Alternative Names: (4-Fluoro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone. Grades: Highly Purified. CAS No. 1364933-59-4. Pack Sizes: 1mg. Molecular Formula: C24H22FNO, Molecular Weight: 359.44. US Biological Life Sciences. | Worldwide |
| JX 06 | JX 06 is a potent, selective and covalent pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor with IC50 values of 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively. It suppresses A549 lung cancer cell proliferation in vitro and reduces tumor volume of A549 xenografts in mice. Synonyms: JX-06; JX06; Bis(morpholinothiocarbonyl) Disulfide; 4, 4'- (Dithiodicarbonothioyl) bis[morpholine]; 4-Morpholinethiocarbonyl Disulfide; Dimorpholinethiuram Disulfide; Disulfide, bis(4-Morpholinylthioxomethyl); NSC 402538; bis(Oxydi-2,1-ethanediyl)-thiuram Disulfide. Grades: ≥98% by HPLC. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.51. |  |
| JX-06 | JX-06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 28, 49 and 313 nM for PDK2, PDK1 and PDK3, respectively). JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. JX06, as a selective covalent inhibitor of PDK1 in cells, forms a disulfide bond with the thiol group of a conserved cysteine residue (C240) based on recognition of a hydrophobic pocket adjacent to the ATP pocket of the PDK1 enzyme. Group: Inhibitors. Alternative Names: JX-06; JX 06; JX06. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.49. Appearance: Solid powder. Purity: >98%. IUPACName: Bis(morpholinothiocarbonyl) disulfide. Canonical SMILES: S=C(SSC(N1CCOCC1)=S)N2CCOCC2. Catalog: ACM729464. |  |
| JX 401 | JX 401, cell-permeable piperidinamide compound, is a reversible and highly potent inhibitor of p38α isoform MAP kinase containing a 4-benzylpiperidine motif. Its IC50 value is 32 nM and displays no activity on the p38γ isoform. It effectively blocks the differentiation of L8 myoblasts to myotubes in a reversible manner and blocks the differentiation of myoblasts and myotubes in mammalian cells in culture. It is not a competitive inhibitor with respect to either ATP or substrate. It is hyperactive in inflammatory diseases and may reverse inflammation. Synonyms: JX-401; JX 401; JX401; 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine; [2-Methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-methanone; N-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine. Grades: ≥98% by HPLC. CAS No. 349087-34-9. Molecular formula: C21H25NO2S. Mole weight: 355.49. | |
| JX 401 | JX 401. Group: Biochemicals. Grades: Purified. CAS No. 349087-34-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JYL1421 | JYL1421 is a TRPV1 receptor antagonist. JYL1421 concentration-dependently (0.1-2 mM) inhibited capsaicin-evoked substance P, calcitonin gene-related peptide and somatostatin release from isolated tracheae. It also concentration-dependently decreased capsaicin-induced Ca(2+) accumulation in cultured trigeminal ganglion cells. Synonyms: 3-[ (4-Tert-butylphenyl) methyl]-1-[ (3-fluoro-4-methanesulfonamidophenyl) methyl]thiourea. Grades: ≥95%. CAS No. 401907-26-4. Molecular formula: C20H26FN3O2S2. Mole weight: 423.6. | |
| JYN42346 | JYN42346, also known as Complement factor D-IN-2, is an inhibitor of complement factor D. JYN42346 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. JYN42346 can be used for the research of autoimmune diseases. JYN42346 was first reported in patent WO2015130838A1 (compound 190). Group: Inhibitors. Alternative Names: Complement factor D-IN-2; JYN42346; JYN 42346; JYN-42346. CAS No. 1903742-34-6. Molecular formula: C27H24BrN7O3. Mole weight: 574.44. Appearance: Solid powder. Purity: >98%. IUPACName: (1R,3S,5R)-2-(2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide. Canonical SMILES: O=C ([C@H]1N (C (CN2N=C (C (C)=O)C3=C2C=CC (C4=CN=C (C)N=C4)=C3)=O)[C@]5 ([H])C[C@]5 ([H])C1)NC6=NC (Br)=CC=C6. Catalog: ACM1903742346. | |
| JZL184 | JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM. Synonyms: JZL184; JZL 184; JZL-184. Grades: >98%. CAS No. 1101854-58-3. Molecular formula: C27H24N2O9. Mole weight: 520.49. | |
| JZL195 | JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC 50 s of 2 and 4 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1210004-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15250. |  |
| JZL195 | JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo. Synonyms: JZL195; JZL-195; JZL 195. Grades: >98%. CAS No. 1210004-12-8. Molecular formula: C24H23N3O5. Mole weight: 433.46. | |
| JZL 195 | JZL 195. Group: Biochemicals. Grades: Purified. CAS No. 1210004-12-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JZP 361 | JZP 361 is a reversible, potent and selective inhibitor of human recombinant MAGL (hMAGL) with IC50 value of 46 nM. It shows affinity for H1 receptors but shows no activity at cannabinoid receptors. It has MAGL-inhibitory and antihistaminergic and may be a novel dual-acting pharmacological tool. Synonyms: JZP-361; JZP 361; JZP361; [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone. Grades: ≥99% by HPLC. CAS No. 1680193-80-9. Molecular formula: C22H20ClN5O. Mole weight: 405.88. | |
| JZP-430 | JZP-430, a thiadiazol derivative, has been found to be an ABHD6 inhibitor that could probably be effective in obesity and type?II diabetes therapy. IC50: 44 nM. Synonyms: JZP-430; JZP 430; JZP430; 4-morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate. Grades: 98%. CAS No. 1672691-74-5. Molecular formula: C16H26N4O3S. Mole weight: 354.47. | |
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